Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	HEAT_type_2	ATR TEX10 KPNB1	4.39e-05	17	77	3	IPR021133
Domain	FN3	MYBPH FSD1L PTPRG SPEG CRLF3 OBSCN	1.15e-04	185	77	6	SM00060
Domain	FN3	MYBPH FSD1L PTPRG SPEG CRLF3 OBSCN	1.72e-04	199	77	6	PS50853
Domain	FN3_dom	MYBPH FSD1L PTPRG SPEG CRLF3 OBSCN	2.24e-04	209	77	6	IPR003961
Domain	fn3	MYBPH FSD1L PTPRG SPEG OBSCN	5.51e-04	162	77	5	PF00041
Domain	HEAT	ATR TEX10 KPNB1	1.02e-03	48	77	3	PF02985
Domain	CRAL-bd_toc_tran	SEC14L6 SEC14L4	1.08e-03	12	77	2	IPR001071
Domain	CRAL_TRIO_N	SEC14L6 SEC14L4	1.08e-03	12	77	2	SM01100
Domain	CRAL/TRIO_N_dom	SEC14L6 SEC14L4	1.70e-03	15	77	2	IPR011074
Domain	HEAT	ATR TEX10 KPNB1	1.77e-03	58	77	3	IPR000357
Domain	GOLD_dom	SEC14L6 SEC14L4	2.74e-03	19	77	2	IPR009038
Domain	GOLD	SEC14L6 SEC14L4	2.74e-03	19	77	2	PS50866
Domain	HEAT_REPEAT	ATR TEX10 KPNB1	3.02e-03	70	77	3	PS50077
Domain	SRCR	CD163L1 HHIPL1	3.35e-03	21	77	2	PF00530
Domain	CRAL_TRIO	SEC14L6 SEC14L4	3.35e-03	21	77	2	PF00650
Domain	-	SEC14L6 SEC14L4	4.01e-03	23	77	2	3.40.525.10
Domain	SR	CD163L1 HHIPL1	4.73e-03	25	77	2	SM00202
Domain	SEC14	SEC14L6 SEC14L4	4.73e-03	25	77	2	SM00516
Domain	-	CD163L1 HHIPL1	4.73e-03	25	77	2	3.10.250.10
Domain	Ricin_B_lectin	GALNT5 GALNT4	4.73e-03	25	77	2	PF00652
Domain	SRCR_1	CD163L1 HHIPL1	5.11e-03	26	77	2	PS00420
Domain	SRCR_2	CD163L1 HHIPL1	5.11e-03	26	77	2	PS50287
Domain	SRCR-like_dom	CD163L1 HHIPL1	5.11e-03	26	77	2	IPR017448
Pubmed	Orthologous relationship of obscurin and Unc-89: phylogeny of a novel family of tandem myosin light chain kinases.	SPEG OBSCN	5.49e-06	2	82	2	15185077
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TBC1D16 SLC6A8 GAS2L1 URB1 SPEG PIEZO1 OBSCN ANKLE1 HERC2 TAGLN TRAPPC9 PCNT	1.07e-05	1105	82	12	35748872
Pubmed	RNA Sensing by Gut Piezo1 Is Essential for Systemic Serotonin Synthesis.	PIEZO1 TLR7	1.64e-05	3	82	2	32640190
Pubmed	Protein tyrosine phosphatase receptor type γ is a JAK phosphatase and negatively regulates leukocyte integrin activation.	PTPRG ITGB2	1.64e-05	3	82	2	25624455
Pubmed	Coordinated regulation of XPA stability by ATR and HERC2 during nucleotide excision repair.	ATR HERC2	1.64e-05	3	82	2	23178497
Pubmed	The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation.	ATR PIEZO1	1.64e-05	3	82	2	34158506
Pubmed	alpha-Tocopherol transfer protein inhibition is effective in the prevention of cerebral malaria in mice.	SEC14L6 SEC14L4	1.64e-05	3	82	2	19923370
Pubmed	Complement receptor 3 influences toll-like receptor 7/8-dependent inflammation: implications for autoimmune diseases characterized by antibody reactivity to ribonucleoproteins.	TLR7 ITGB2	1.64e-05	3	82	2	23386618
Pubmed	Molecular cloning and characterization of cDNA for eukaryotic transcription factor S-II.	SEC14L6 SEC14L4	3.28e-05	4	82	2	3346229
Pubmed	Regulation of hepatic cholesterol synthesis by a novel protein (SPF) that accelerates cholesterol biosynthesis.	SEC14L6 SEC14L4	3.28e-05	4	82	2	17077281
Pubmed	Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking.	MST1 ITGB2	3.28e-05	4	82	2	25074980
Pubmed	HERC2/USP20 coordinates CHK1 activation by modulating CLASPIN stability.	ATR HERC2	3.28e-05	4	82	2	25326330
Pubmed	Phosphorylation of smooth muscle 22α facilitates angiotensin II-induced ROS production via activation of the PKCδ-P47phox axis through release of PKCδ and actin dynamics and is associated with hypertrophy and hyperplasia of vascular smooth muscle cells in vitro and in vivo.	JAK1 TAGLN	3.28e-05	4	82	2	22798525
Pubmed	A HeLa-cell-encoded p21 is homologous to transcription elongation factor SII.	SEC14L6 SEC14L4	5.47e-05	5	82	2	8206389
Pubmed	Defining the membrane proteome of NK cells.	ABHD17B LRRC40 ENPP4 HERC2 CPT1A ITGB2 STAG2 EXOC8 PCNT KPNB1 NUP205	9.24e-05	1168	82	11	19946888
Pubmed	MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane.	MST1 SYTL1	1.14e-04	7	82	2	27701149
Pubmed	The interaction of Epac1 and Ran promotes Rap1 activation at the nuclear envelope.	KPNB1 NUP205	1.14e-04	7	82	2	20547757
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	LSR URB1 SMARCA5 LRRC40 HERC2 TEX10 STAG2 PCNT KPNB1 NUP205	1.47e-04	1024	82	10	24711643
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	JAK1 BCKDHB HERC2 CPT1A PCNT	1.50e-04	212	82	5	33853758
Pubmed	Spurious transcription causing innate immune responses is prevented by 5-hydroxymethylcytosine.	TET2 TLR7	1.52e-04	8	82	2	36539616
Pubmed	Diverse spatial expression patterns of UDP-GalNAc:polypeptide N-acetylgalactosaminyl-transferase family member mRNAs during mouse development.	GALNT5 GALNT4	1.52e-04	8	82	2	11159923
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	URB1 SMARCA5 HERC2 TEX10 STAG2 PCNT KPNB1 NUP205	1.56e-04	653	82	8	22586326
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	MYBPH ZNF793 RETREG1 OBSCN PYGM STAG2 KPNB1	1.76e-04	497	82	7	23414517
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	RLF ZNF793 PTPRG ARID5B OBSCN LZTS2 CPT1A SYTL1 STAG2 TRAPPC9 PCNT PDZD2	1.88e-04	1489	82	12	28611215
Pubmed	EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylation.	SMARCA5 CCDC180 STAG2 NUP205	2.45e-04	128	82	4	23858473
Pubmed	Intrinsic neural stem cell properties define brain hypersensitivity to genotoxic stress.	ATR PCNT	3.57e-04	12	82	2	35623353
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	LSR URB1 LRRC40 CPT1A TEX10 STAG2 EXOC8 KPNB1 NUP205	3.78e-04	942	82	9	31073040
Pubmed	RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity.	SMARCA5 ARID5B TEX10 KPNB1	4.04e-04	146	82	4	21589869
Pubmed	Mouse models of psoriasis.	TTC7A ITGB2	4.21e-04	13	82	2	17429444
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	URB1 SMARCA5 PNMA1 AGGF1 BCKDHB HERC2 TEX10 NUP205	4.27e-04	759	82	8	35915203
Pubmed	Histone Deacetylase 3 Coordinates Deacetylase-independent Epigenetic Silencing of Transforming Growth Factor-β1 (TGF-β1) to Orchestrate Second Heart Field Development.	TAGLN KPNB1	6.45e-04	16	82	2	26420484
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	SLC6A8 DPH1 LSR URB1 PIEZO1 RETREG1 LRRC40 BCKDHB LZTS2 HERC2 PCNT	7.26e-04	1487	82	11	33957083
Pubmed	The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates.	KPNB1 NUP205	7.30e-04	17	82	2	10668806
Pubmed	Probing nuclear pore complex architecture with proximity-dependent biotinylation.	KPNB1 NUP205 PDZD2	8.15e-04	77	82	3	24927568
Pubmed	An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse.	RLF SMARCA5	8.20e-04	18	82	2	24025402
Pubmed	Novel cell lines promote the discovery of genes involved in early heart development.	JAK1 TAGLN	8.20e-04	18	82	2	11437454
Pubmed	Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1.	SMARCA5 KPNB1	1.01e-03	20	82	2	18162579
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	RLF MST1 SLC6A8 DPH1 ARID5B SLC23A1 PCNT NUP205 SIAH3 AZIN1	1.12e-03	1327	82	10	32694731
Pubmed	Programmed cell senescence during mammalian embryonic development.	ATR PCNT	1.12e-03	21	82	2	24238962
Pubmed	Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.	ATR HERC2 KPNB1	1.16e-03	87	82	3	17148452
Pubmed	Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21.	JAK1 PCNT	1.23e-03	22	82	2	26631746
Pubmed	Overexpression of Galnt3 in chondrocytes resulted in dwarfism due to the increase of mucin-type O-glycans and reduction of glycosaminoglycans.	GALNT5 GALNT4	1.23e-03	22	82	2	25107907
Pubmed	Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity.	THRSP CPT1A	1.35e-03	23	82	2	26508642
Pubmed	Exploring the link between MORF4L1 and risk of breast cancer.	ATR KPNB1	1.47e-03	24	82	2	21466675
Pubmed	Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome.	GALNT5 GALNT4	1.47e-03	24	82	2	31882545
Pubmed	Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding.	GALNT5 GALNT4	1.47e-03	24	82	2	31740596
Pubmed	Transcriptional Repression of Aerobic Glycolysis by OVOL2 in Breast Cancer.	LSR SMARCA5 KPNB1	1.50e-03	95	82	3	35896951
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TET2 PIEZO1 HHIPL1 LZTS2 ERI2 NUP205	1.59e-03	529	82	6	14621295
Pubmed	Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span.	THRSP ATR	1.59e-03	25	82	2	23563309
Pubmed	GGPP depletion initiates metaflammation through disequilibrating CYB5R3-dependent eicosanoid metabolism.	TAGLN CPT1A	1.59e-03	25	82	2	32913122
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	P2RX2 TLR7 ITGB2	1.78e-03	101	82	3	23382219
Pubmed	The RNA-binding protein HuR is a novel target of Pirh2 E3 ubiquitin ligase.	URB1 SMARCA5 STAG2 NUP205	1.85e-03	220	82	4	34091597
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	GREB1L TBC1D16 SEC14L6 PGGHG PIEZO1 OBSCN LZTS2 HERC2 AZIN1	2.24e-03	1215	82	9	15146197
Pubmed	Chromatin Remodeling Enzyme Snf2h Is Essential for Retinal Cell Proliferation and Photoreceptor Maintenance.	SMARCA5 ATR	2.29e-03	30	82	2	37048108
Interaction	RAPGEF3 interactions	PNMA1 EXOC8 KPNB1 NUP205	1.59e-06	22	80	4	int:RAPGEF3
Cytoband	22q12.2	GAS2L1 SEC14L6 SEC14L4	1.58e-04	58	82	3	22q12.2
Cytoband	19q13.12	ZNF793 LSR LGI4	3.00e-04	72	82	3	19q13.12
GeneFamily	Fibronectin type III domain containing	MYBPH FSD1L PTPRG CRLF3 OBSCN	1.04e-04	160	53	5	555
GeneFamily	SEC14 family\|PRELI domain containing	SEC14L6 SEC14L4	1.26e-04	6	53	2	1063
GeneFamily	Polypeptide N-acetylgalactosaminyltransferases	GALNT5 GALNT4	1.55e-03	20	53	2	433
Disease	Seckel syndrome 1	ATR PCNT	2.12e-05	3	79	2	C4551474
Disease	psoriasis (implicated_via_orthology)	TTC7A ITGB2	1.47e-04	7	79	2	DOID:8893 (implicated_via_orthology)
Disease	Polycythemia Vera	JAK1 TET2	1.96e-04	8	79	2	C0032463
Disease	mean reticulocyte volume	TTC7A TBC1D16 ATR PIEZO1 ENPP4 STAG2 TRAPPC9 NUP205 AZIN1	2.83e-04	799	79	9	EFO_0010701
Disease	Precursor Cell Lymphoblastic Leukemia Lymphoma	JAK1 ARID5B MTRR	5.94e-04	61	79	3	C1961102
Disease	Moyamoya Disease	ABCC6 PCNT	9.38e-04	17	79	2	C0026654
Disease	Chronic myeloproliferative disorder	ATR PCNT	1.18e-03	19	79	2	C1292778
Disease	hepatocellular carcinoma (is_implicated_in)	JAK1 TET2 MTRR AZIN1	1.44e-03	181	79	4	DOID:684 (is_implicated_in)
Disease	acute myeloid leukemia (is_implicated_in)	TET2 MTRR DLEC1	1.51e-03	84	79	3	DOID:9119 (is_implicated_in)
Disease	Seckel syndrome	ATR PCNT	1.58e-03	22	79	2	C0265202
Disease	inflammatory bowel disease (implicated_via_orthology)	MST1 PDZD2	2.04e-03	25	79	2	DOID:0050589 (implicated_via_orthology)
Disease	non-alcoholic fatty liver disease severity measurement	PTPRG TRAPPC9	2.56e-03	28	79	2	EFO_0008421

Protein segments in the cluster

Peptide	Gene	Start	Entry
CSEIVEWIVFRRPVP	PTPRG	261	P23470
CLPVLADWEDVVLLP	ERI2	401	A8K979
REEEPWAVEELLRCG	ANKLE1	16	Q8NAG6
ESCLLPELNVGDWLI	AZIN1	366	O14977
VIDRGLQLVPVWDII	GVINP1	461	Q7Z2Y8
QREWPEIRQILENPC	ASB15	521	Q8WXK1
TRLQWDIPGECQEVI	CPT1A	516	P50416
DEDKIWPPCIRVIVI	AGGF1	401	Q8N302
DIQRIIWGCPTLSEV	ECT2L	766	Q008S8
IRRFEELLPQVCWLV	CCDC180	1446	Q9P1Z9
PAVLRPIWLDDILCQ	CD163L1	211	Q9NR16
LPEVDVWVQVACPRL	DPH1	336	Q9BZG8
VIVLRGAWAVPRVDC	ANKRD33	26	Q7Z3H0
VLSRQECIERIPWIA	JAK1	746	P23458
ECIERIPWIAPECVE	JAK1	751	P23458
WRQLVEIILTACPQD	NUP205	1286	Q92621
GLEPCLQLKELWIAE	LRRC9	71	Q6ZRR7
GVSCEVIDLRTIIPW	BCKDHB	296	P21953
DWVPKELQRVGCVEL	MPPED2	221	Q15777
ELGPRLEETKWEVCQ	LZTS2	431	Q9BRK4
LPILLDDVRCAGWER	HHIPL1	736	Q96JK4
EWSIGLRVPFVVDIC	HERC2	781	O95714
LHEGWPLCLRDEVVV	KIAA1755	76	Q5JYT7
GLPRVKDERCWEIID	FSD1L	241	Q9BXM9
DCVGLELVVEPWIAG	MTRR	131	Q9UBK8
GPVLDVGCIWVTELR	PDZD2	111	O15018
EELIEKPGGIIVRWC	CRLF3	186	Q8IUI8
LVDQWCINLPEAIAI	ENPP4	396	Q9Y6X5
VRWVDPTALCEELLL	METTL25B	226	Q96FB5
AQLWVECGLDVVGPL	PGGHG	236	Q32M88
WIQELPEDLDVCIAQ	EXOC8	336	Q8IYI6
EELGIKRQCVWPFIV	GREB1L	1601	Q9C091
RWVFLVAILEGVQCE	IGHV3-21	6	A0A0B4J1V1
CPDWRGDLLQVVQEA	PCNT	2446	O95613
QWVAPGEDVELRCEL	OBSCN	2836	Q5VST9
VIGVIINWDCDLDLP	P2RX2	261	Q9UBL9
CPEEIGWRNVTRLLV	ITGB2	246	P05107
QEVEVCCPWELSILI	PRAMEF12	206	O95522
AVIPLNDECGIIEWV	ATR	2366	Q13535
LPRQISDGLVEITWC	CARD6	496	Q9BX69
FIGWCRVELGVPEVL	GAS2L1	106	Q99501
ECNSGWLEPLLERIG	GALNT4	231	Q8N4A0
VECNVGWLEPLLERV	GALNT5	591	Q7Z7M9
LQAPRWPIECEVIKE	AGBL2	176	Q5U5Z8
IACAEIPVNQWPELI	KPNB1	116	Q14974
LCGEQVAVEWLKPDL	DND1	206	Q8IYX4
NCWVLEGIIIPNRVC	MST1	671	P26927
WDNLICTVGDLLPEV	DLEC1	1216	Q9Y238
LLVWGIPVNCDEAEI	PNMA1	21	Q8ND90
QVENEILFPGCVLRW	SEC14L4	291	Q9UDX3
QVENEILFPGCVLRW	SEC14L6	291	B5MCN3
VPQCVWRINVDIPEE	LRRC40	51	Q9H9A6
PIEDWLFVVVVCLAA	LSR	256	Q86X29
LEQPCEWVDGLLPLR	SYTL1	541	Q8IYJ3
DLVCDLGWQVILEQI	SLC22A17	91	Q8WUG5
ELLWLEGQPCFVVAD	LGI4	321	Q8N135
WLERVLEACALQPDV	ABCC6	721	O95255
LLGEPVLWLGCRADE	RETREG1	71	Q9H6L5
VIRPGCELLVWSGDE	PRDM7	346	Q9NQW5
LFSCQWEGRLEVVVP	SIAH3	111	Q8IW03
VLELCREGASEWVPV	MYBPH	106	Q13203
EVPGALNWEVTLCLL	SLC6A8	226	P48029
LEERLVEWIIVQCGP	TAGLN	26	Q01995
PLCDEAAQNWILEIL	URB1	1821	O60287
LFERCQRPVEPLWVE	ABHD17B	246	Q5VST6
PICIAELQLLWEERT	ARID5B	51	Q14865
VILRLEQEEAPWIGE	ZNF793	56	Q6ZN11
QVLVDGAPVRIELWD	RHOV	71	Q96L33
RWLVLCNPGLAEVIA	PYGM	491	P11217
PCLWQLETELREQEV	RLF	51	Q13129
DVEVDWLCRGRLLQP	SPEG	996	Q15772
ILALERWKCPPEEEI	SLC23A1	121	Q9UHI7
IAEIRAICIEEIGIW	STAG2	301	Q8N3U4
GALPRLCDVLQVLWE	SCTR	26	P47872
PRWDEPQRVCALEQI	TBC1D16	281	Q8TBP0
IEIIIPLLIECWVEA	TEX10	321	Q9NXF1
LCLEERDWLPGQPVL	TLR7	926	Q9NYK1
PEEALVTCRQVLRLW	TTC7A	616	Q9ULT0
LQWDVLVDGQPCDRE	TRAPPC9	1016	Q96Q05
CLLPVEEAGIIWDSV	PIEZO1	1276	Q92508
VRDVLLPGEWDVCVT	SMARCA5	271	O60264
ICVDVDHGLLPREEW	THRSP	66	Q92748
CEAAVIVILILVWEG	TET2	1221	Q6N021
WNCIPIEEQLQLVLG	nan	51	Q499Y3