Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	SLC6A8 CACNA1S SLC5A6 UCP2 KCNMA1 KCNN3 SLC38A7 HTR3C KCNG3 SLC4A5 CNGA4 SLC29A4 SLC36A2 SLC5A2	5.88e-09	664	59	14	GO:0008324
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC6A8 CACNA1S ATP11B SLC5A6 UCP2 KCNMA1 KCNN3 SLC38A7 HTR3C KCNG3 SLC4A5 CNGA4 SLC29A4 SLC36A2 SLC5A2	6.60e-09	793	59	15	GO:0015075
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC6A8 CACNA1S ATP11B ABCA6 SLC5A6 SLC43A1 UCP2 KCNMA1 KCNN3 SLC38A7 HTR3C KCNG3 SLC4A5 CNGA4 SLC29A4 SLC36A2 SLC5A2	3.04e-08	1180	59	17	GO:0022857
GeneOntologyMolecularFunction	transporter activity	SLC6A8 CACNA1S ATP11B ABCA6 SLC5A6 SLC43A1 UCP2 KCNMA1 KCNN3 SLC38A7 HTR3C KCNG3 SLC4A5 CNGA4 SLC29A4 SLC36A2 SLC5A2	1.10e-07	1289	59	17	GO:0005215
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	SLC6A8 CACNA1S SLC5A6 UCP2 KCNMA1 KCNN3 SLC38A7 KCNG3 SLC4A5 CNGA4 SLC36A2 SLC5A2	2.40e-07	627	59	12	GO:0022890
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC6A8 CACNA1S SLC5A6 KCNMA1 KCNN3 SLC38A7 KCNG3 SLC4A5 CNGA4 SLC5A2	9.63e-07	465	59	10	GO:0046873
GeneOntologyMolecularFunction	solute:monoatomic cation symporter activity	SLC6A8 SLC5A6 SLC38A7 SLC4A5 SLC36A2 SLC5A2	1.37e-06	119	59	6	GO:0015294
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC6A8 CACNA1S SLC5A6 UCP2 KCNMA1 KCNN3 SLC38A7 KCNG3 SLC4A5 CNGA4 SLC36A2 SLC5A2	1.78e-06	758	59	12	GO:0015318
GeneOntologyMolecularFunction	organic acid transmembrane transporter activity	SLC6A8 SLC5A6 SLC43A1 UCP2 SLC38A7 SLC29A4 SLC36A2	2.59e-06	208	59	7	GO:0005342
GeneOntologyMolecularFunction	solute:sodium symporter activity	SLC6A8 SLC5A6 SLC38A7 SLC4A5 SLC5A2	4.09e-06	81	59	5	GO:0015370
GeneOntologyMolecularFunction	organic cation transmembrane transporter activity	SLC6A8 SLC43A1 SLC38A7 SLC29A4 SLC36A2	4.61e-06	83	59	5	GO:0015101
GeneOntologyMolecularFunction	symporter activity	SLC6A8 SLC5A6 SLC38A7 SLC4A5 SLC36A2 SLC5A2	5.28e-06	150	59	6	GO:0015293
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC6A8 ABCA6 SLC5A6 UCP2 SLC38A7 SLC4A5 SLC29A4 SLC36A2 SLC5A2	1.02e-05	477	59	9	GO:0022804
GeneOntologyMolecularFunction	amino acid transmembrane transporter activity	SLC6A8 SLC43A1 UCP2 SLC38A7 SLC36A2	1.46e-05	105	59	5	GO:0015171
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	SLC6A8 SLC5A6 SLC43A1 UCP2 SLC38A7 SLC4A5 SLC36A2	2.42e-05	293	59	7	GO:0008514
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC6A8 SLC5A6 UCP2 SLC38A7 SLC4A5 SLC36A2 SLC5A2	2.58e-05	296	59	7	GO:0015291
GeneOntologyMolecularFunction	carboxylic acid transmembrane transporter activity	SLC6A8 SLC5A6 SLC43A1 UCP2 SLC38A7 SLC36A2	3.29e-05	207	59	6	GO:0046943
GeneOntologyMolecularFunction	L-amino acid transmembrane transporter activity	SLC43A1 UCP2 SLC38A7 SLC36A2	5.76e-05	71	59	4	GO:0015179
GeneOntologyMolecularFunction	amino acid:monoatomic cation symporter activity	SLC6A8 SLC38A7 SLC36A2	8.48e-05	29	59	3	GO:0005416
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC6A8 SLC5A6 SLC38A7 SLC4A5 SLC5A2	1.50e-04	171	59	5	GO:0015081
GeneOntologyMolecularFunction	organic acid:sodium symporter activity	SLC6A8 SLC5A6 SLC38A7	1.50e-04	35	59	3	GO:0005343
GeneOntologyMolecularFunction	neutral L-amino acid transmembrane transporter activity	SLC43A1 SLC38A7 SLC36A2	2.41e-04	41	59	3	GO:0015175
GeneOntologyMolecularFunction	active monoatomic ion transmembrane transporter activity	SLC6A8 SLC5A6 SLC38A7 SLC4A5 SLC36A2 SLC5A2	2.57e-04	301	59	6	GO:0022853
GeneOntologyMolecularFunction	gated channel activity	CACNA1S KCNMA1 KCNN3 HTR3C KCNG3 CNGA4	4.47e-04	334	59	6	GO:0022836
GeneOntologyMolecularFunction	monoatomic cation channel activity	CACNA1S KCNMA1 KCNN3 HTR3C KCNG3 CNGA4	5.15e-04	343	59	6	GO:0005261
GeneOntologyMolecularFunction	calcium-activated potassium channel activity	KCNMA1 KCNN3	7.63e-04	14	59	2	GO:0015269
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	KCNMA1 KCNN3 HTR3C CNGA4	7.81e-04	140	59	4	GO:0099094
GeneOntologyMolecularFunction	monocarboxylate:sodium symporter activity	SLC6A8 SLC5A6	8.79e-04	15	59	2	GO:0140161
GeneOntologyMolecularFunction	alanine transmembrane transporter activity	SLC38A7 SLC36A2	1.00e-03	16	59	2	GO:0022858
GeneOntologyMolecularFunction	monoatomic anion transmembrane transporter activity	SLC6A8 SLC5A6 UCP2 SLC4A5	1.04e-03	151	59	4	GO:0008509
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	CACNA1S KCNMA1 KCNN3 KCNG3	1.06e-03	152	59	4	GO:0022843
GeneOntologyMolecularFunction	secondary active monocarboxylate transmembrane transporter activity	SLC6A8 SLC5A6	1.42e-03	19	59	2	GO:0015355
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	SLC6A8 SLC5A6 UCP2 SLC4A5	1.64e-03	171	59	4	GO:0015103
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	CACNA1S KCNMA1 KCNN3 KCNG3	2.06e-03	182	59	4	GO:0005244
GeneOntologyMolecularFunction	amino acid:sodium symporter activity	SLC6A8 SLC38A7	2.09e-03	23	59	2	GO:0005283
GeneOntologyMolecularFunction	voltage-gated channel activity	CACNA1S KCNMA1 KCNN3 KCNG3	2.14e-03	184	59	4	GO:0022832
GeneOntologyMolecularFunction	monoatomic ion channel activity	CACNA1S KCNMA1 KCNN3 HTR3C KCNG3 CNGA4	2.30e-03	459	59	6	GO:0005216
GeneOntologyMolecularFunction	hydrolase activity, acting on ester bonds	PLPP5 CPT1C PLA2G4A G6PC1 DICER1 GNS PGBD5 SACM1L	2.46e-03	807	59	8	GO:0016788
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	KCNMA1 KCNN3 HTR3C CNGA4	2.54e-03	193	59	4	GO:0015276
GeneOntologyMolecularFunction	ligand-gated channel activity	KCNMA1 KCNN3 HTR3C CNGA4	2.74e-03	197	59	4	GO:0022834
GeneOntologyMolecularFunction	calcium-activated cation channel activity	KCNMA1 KCNN3	2.87e-03	27	59	2	GO:0005227
GeneOntologyMolecularFunction	voltage-gated potassium channel activity	KCNMA1 KCNN3 KCNG3	3.42e-03	102	59	3	GO:0005249
GeneOntologyMolecularFunction	monoatomic ion-gated channel activity	KCNMA1 KCNN3	3.78e-03	31	59	2	GO:0022839
GeneOntologyMolecularFunction	modified amino acid transmembrane transporter activity	SLC6A8 SLC5A6	4.27e-03	33	59	2	GO:0072349
GeneOntologyMolecularFunction	channel activity	CACNA1S KCNMA1 KCNN3 HTR3C KCNG3 CNGA4	4.45e-03	525	59	6	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	CACNA1S KCNMA1 KCNN3 HTR3C KCNG3 CNGA4	4.49e-03	526	59	6	GO:0022803
GeneOntologyMolecularFunction	potassium channel activity	KCNMA1 KCNN3 KCNG3	6.44e-03	128	59	3	GO:0005267
GeneOntologyMolecularFunction	amide transmembrane transporter activity	SLC5A6 SLC38A7	6.85e-03	42	59	2	GO:0042887
GeneOntologyMolecularFunction	olfactory receptor activity	OR2T6 OR5C1 OR2D3 OR4K3 OR4K14	8.82e-03	431	59	5	GO:0004984
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	SLC6A8 CACNA1S ATP11B MTOR SLC5A6 UCP2 KCNMA1 KCNN3 HTR3C KCNG3 SLC4A5 CNGA4 SLC29A4 SLC36A2 SLC5A2	4.80e-07	1115	60	15	GO:0034220
GeneOntologyBiologicalProcess	monoatomic ion transport	SLC6A8 CACNA1S ATP11B MTOR SLC5A6 UCP2 KCNMA1 KCNN3 SLC38A7 HTR3C KCNG3 SLC4A5 CNGA4 SLC29A4 SLC36A2 SLC5A2	1.26e-06	1374	60	16	GO:0006811
GeneOntologyBiologicalProcess	organic anion transport	SLC6A8 SLC5A6 SLC43A1 UCP2 SLC38A7 PLA2G4A NR3C1 G6PC1 SLC4A5 SLC36A2	2.12e-06	515	60	10	GO:0015711
GeneOntologyBiologicalProcess	organic acid transport	SLC6A8 SLC5A6 SLC43A1 UCP2 SLC38A7 PLA2G4A NR3C1 SLC29A4 SLC36A2	2.79e-06	412	60	9	GO:0015849
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	SLC6A8 CACNA1S MTOR SLC5A6 UCP2 KCNMA1 KCNN3 HTR3C KCNG3 SLC4A5 CNGA4 SLC36A2 SLC5A2	5.62e-06	1017	60	13	GO:0098660
GeneOntologyBiologicalProcess	organic acid transmembrane transport	SLC6A8 SLC5A6 SLC43A1 UCP2 SLC29A4 SLC36A2	8.98e-06	167	60	6	GO:1903825
GeneOntologyBiologicalProcess	inorganic cation transmembrane transport	SLC6A8 CACNA1S SLC5A6 UCP2 KCNMA1 KCNN3 HTR3C KCNG3 SLC4A5 CNGA4 SLC36A2 SLC5A2	1.14e-05	922	60	12	GO:0098662
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	SLC6A8 CACNA1S SLC5A6 UCP2 KCNMA1 KCNN3 KCNG3 SLC4A5 CNGA4 SLC29A4 SLC36A2 SLC5A2	1.41e-05	942	60	12	GO:0098655
GeneOntologyBiologicalProcess	amino acid transport	SLC6A8 SLC43A1 UCP2 SLC38A7 NR3C1 SLC36A2	2.17e-05	195	60	6	GO:0006865
GeneOntologyBiologicalProcess	monoatomic cation transport	SLC6A8 CACNA1S SLC5A6 UCP2 KCNMA1 KCNN3 SLC38A7 KCNG3 SLC4A5 CNGA4 SLC29A4 SLC36A2 SLC5A2	2.23e-05	1157	60	13	GO:0006812
GeneOntologyBiologicalProcess	carboxylic acid transport	SLC6A8 SLC5A6 SLC43A1 UCP2 SLC38A7 PLA2G4A NR3C1 SLC36A2	2.36e-05	410	60	8	GO:0046942
GeneOntologyBiologicalProcess	iodide transmembrane transport	MTOR SLC5A6	2.49e-05	3	60	2	GO:1904200
GeneOntologyBiologicalProcess	carboxylic acid transmembrane transport	SLC6A8 SLC5A6 SLC43A1 UCP2 SLC36A2	1.11e-04	163	60	5	GO:1905039
GeneOntologyBiologicalProcess	metal ion transport	SLC6A8 CACNA1S SLC5A6 UCP2 KCNMA1 KCNN3 SLC38A7 KCNG3 SLC4A5 CNGA4 SLC5A2	1.27e-04	1000	60	11	GO:0030001
GeneOntologyBiologicalProcess	sodium ion transport	SLC6A8 SLC5A6 SLC38A7 SLC4A5 CNGA4 SLC5A2	1.46e-04	275	60	6	GO:0006814
GeneOntologyBiologicalProcess	regulation of organic acid transport	SLC43A1 PLA2G4A NR3C1 SLC36A2	2.31e-04	103	60	4	GO:0032890
GeneOntologyBiologicalProcess	amino acid transmembrane transport	SLC43A1 UCP2 SLC38A7 SLC36A2	4.13e-04	120	60	4	GO:0003333
GeneOntologyCellularComponent	monoatomic ion channel complex	CACNA1S CPT1C KCNMA1 HTR3C KCNG3 CATSPERG CNGA4 SACM1L	1.20e-05	378	60	8	GO:0034702
GeneOntologyCellularComponent	transporter complex	CACNA1S ATP11B CPT1C KCNMA1 HTR3C KCNG3 CATSPERG CNGA4 SACM1L	2.53e-05	550	60	9	GO:1990351
GeneOntologyCellularComponent	somatodendritic compartment	DIP2B CACNA1S MTOR CPT1C KCNMA1 KCNN3 SLC38A7 BRINP1 NR3C1 CLSTN1 DICER1 CNGA4 EPHA10	3.61e-05	1228	60	13	GO:0036477
GeneOntologyCellularComponent	cation channel complex	CACNA1S KCNMA1 HTR3C KCNG3 CATSPERG CNGA4	5.71e-05	235	60	6	GO:0034703
GeneOntologyCellularComponent	apical plasma membrane	SLC6A8 SYTL4 SLC5A6 SLC43A1 KCNMA1 SLC4A5 SLC29A4 SLC5A2	7.24e-05	487	60	8	GO:0016324
GeneOntologyCellularComponent	transmembrane transporter complex	CACNA1S CPT1C KCNMA1 HTR3C KCNG3 CATSPERG CNGA4 SACM1L	1.19e-04	523	60	8	GO:1902495
GeneOntologyCellularComponent	dendrite	DIP2B CACNA1S MTOR CPT1C KCNMA1 BRINP1 NR3C1 CLSTN1 DICER1 EPHA10	1.51e-04	858	60	10	GO:0030425
GeneOntologyCellularComponent	dendritic tree	DIP2B CACNA1S MTOR CPT1C KCNMA1 BRINP1 NR3C1 CLSTN1 DICER1 EPHA10	1.54e-04	860	60	10	GO:0097447
GeneOntologyCellularComponent	apical part of cell	SLC6A8 SYTL4 SLC5A6 SLC43A1 KCNMA1 SLC4A5 SLC29A4 SLC5A2	2.76e-04	592	60	8	GO:0045177
GeneOntologyCellularComponent	neurotransmitter receptor complex	CPT1C HTR3C SACM1L	4.00e-04	50	60	3	GO:0098878
GeneOntologyCellularComponent	glutamatergic synapse	SLC6A8 MTOR CPT1C KCNMA1 BRINP1 NR3C1 CLSTN1 DICER1 SACM1L	5.03e-04	817	60	9	GO:0098978
GeneOntologyCellularComponent	postsynapse	SLC6A8 CACNA1S ATR MTOR CPT1C KCNMA1 HTR3C NR3C1 CLSTN1 DICER1	5.88e-04	1018	60	10	GO:0098794
GeneOntologyCellularComponent	plasma membrane protein complex	CACNA1S DTNA CPT1C KCNMA1 HTR3C KCNG3 CATSPERG SACM1L	1.74e-03	785	60	8	GO:0098797
MousePheno	decreased mitochondrial fission	UCP2 TMEM135	1.06e-05	2	46	2	MP:0006039
Domain	FATC	SMG1 ATR MTOR	2.98e-07	5	59	3	PF02260
Domain	FAT	SMG1 ATR MTOR	5.95e-07	6	59	3	PS51189
Domain	FATC	SMG1 ATR MTOR	5.95e-07	6	59	3	PS51190
Domain	FATC_dom	SMG1 ATR MTOR	5.95e-07	6	59	3	IPR003152
Domain	PIK_FAT	SMG1 ATR MTOR	5.95e-07	6	59	3	IPR014009
Domain	FATC	SMG1 ATR MTOR	5.95e-07	6	59	3	SM01343
Domain	PI3/4_kinase_CS	SMG1 ATR MTOR	1.33e-05	15	59	3	IPR018936
Domain	-	SMG1 ATR MTOR	1.63e-05	16	59	3	1.10.1070.11
Domain	PI3Kc	SMG1 ATR MTOR	1.63e-05	16	59	3	SM00146
Domain	PI3/4_kinase_cat_dom	SMG1 ATR MTOR	2.36e-05	18	59	3	IPR000403
Domain	PI3_PI4_kinase	SMG1 ATR MTOR	2.36e-05	18	59	3	PF00454
Domain	PI3_4_KINASE_3	SMG1 ATR MTOR	2.36e-05	18	59	3	PS50290
Domain	PI3_4_KINASE_1	SMG1 ATR MTOR	2.36e-05	18	59	3	PS00915
Domain	PI3_4_KINASE_2	SMG1 ATR MTOR	2.36e-05	18	59	3	PS00916
Domain	HEAT_REPEAT	SMG1 ATR MTOR ECPAS	7.05e-05	70	59	4	PS50077
Domain	FAT	ATR MTOR	1.46e-04	6	59	2	PF02259
Domain	PIK-rel_kinase_FAT	ATR MTOR	1.46e-04	6	59	2	IPR003151
Domain	Na/solute_symporter_CS	SLC5A6 SLC5A2	2.71e-04	8	59	2	IPR018212
Domain	Ion_trans_dom	CACNA1S KCNMA1 KCNG3 CNGA4	4.63e-04	114	59	4	IPR005821
Domain	Ion_trans	CACNA1S KCNMA1 KCNG3 CNGA4	4.63e-04	114	59	4	PF00520
Domain	NA_SOLUT_SYMP_1	SLC5A6 SLC5A2	5.30e-04	11	59	2	PS00456
Domain	SOLCAR	SLC25A43 UCP2 MTCH1	6.27e-04	53	59	3	PS50920
Domain	-	SLC25A43 UCP2 MTCH1	6.27e-04	53	59	3	1.50.40.10
Domain	Mitochondrial_sb/sol_carrier	SLC25A43 UCP2 MTCH1	6.27e-04	53	59	3	IPR018108
Domain	Mito_carr	SLC25A43 UCP2 MTCH1	6.27e-04	53	59	3	PF00153
Domain	Mt_carrier_dom	SLC25A43 UCP2 MTCH1	6.27e-04	53	59	3	IPR023395
Domain	NA_SOLUT_SYMP_2	SLC5A6 SLC5A2	6.34e-04	12	59	2	PS00457
Domain	SSF	SLC5A6 SLC5A2	6.34e-04	12	59	2	PF00474
Domain	Na/solute_symporter	SLC5A6 SLC5A2	6.34e-04	12	59	2	IPR001734
Domain	NA_SOLUT_SYMP_3	SLC5A6 SLC5A2	6.34e-04	12	59	2	PS50283
Domain	HEAT	ATR MTOR ECPAS	8.17e-04	58	59	3	IPR000357
Domain	Aa_trans	SLC38A7 SLC36A2	1.29e-03	17	59	2	PF01490
Domain	AA_transpt_TM	SLC38A7 SLC36A2	1.29e-03	17	59	2	IPR013057
Domain	-	PLPP5 G6PC1	1.45e-03	18	59	2	1.20.144.10
Domain	acidPPc	PLPP5 G6PC1	1.45e-03	18	59	2	SM00014
Domain	P_Acid_Pase_2/haloperoxidase	PLPP5 G6PC1	1.80e-03	20	59	2	IPR000326
Domain	PAP2	PLPP5 G6PC1	1.80e-03	20	59	2	PF01569
Domain	Aden_trnslctor	SLC25A43 UCP2	3.52e-03	28	59	2	IPR002113
Domain	Mit_carrier	SLC25A43 UCP2	4.58e-03	32	59	2	IPR002067
Domain	VG_K_chnl	KCNMA1 KCNG3	4.86e-03	33	59	2	IPR028325
Pathway	PID_HNF3B_PATHWAY	CPT1C UCP2 NR3C1 G6PC1	1.73e-05	45	49	4	M106
Pathway	REACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES	ABCA6 NR3C1 G6PC1	1.50e-04	30	49	3	M27941
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC5A6 SLC43A1 SLC4A5 SLC29A4 SLC36A2 SLC5A2	1.66e-04	238	49	6	MM15076
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC5A6 SLC43A1 SLC4A5 SLC29A4 SLC36A2 SLC5A2	2.12e-04	249	49	6	M5988
Pubmed	A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.	SMG1 ATR MTOR	2.72e-07	8	60	3	20810650
Pubmed	Tel2 regulates the stability of PI3K-related protein kinases.	SMG1 ATR MTOR	5.81e-07	10	60	3	18160036
Pubmed	Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.	SMG1 ATR MTOR	7.97e-07	11	60	3	20427287
Pubmed	CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability.	SMG1 ATR MTOR	2.19e-06	15	60	3	20864032
Pubmed	Blockage of cytosolic phospholipase A2 alpha sensitizes aggressive breast cancer to doxorubicin through suppressing ERK and mTOR kinases.	MTOR PLA2G4A	2.93e-06	2	60	2	29307829
Pubmed	Erectile Dysfunction and Altered Contribution of KCa1.1 and KCa2.3 Channels in the Penile Tissue of Type-2 Diabetic db/db Mice.	KCNMA1 KCNN3	2.93e-06	2	60	2	35321830
Pubmed	Effect of the uncoupling protein-2 (UCP-2) and nuclear receptor subfamily 3 group C member 1 (NR3C1) genes on treatment efficacy and survival in patients with multiple myeloma: a single-center study.	UCP2 NR3C1	2.93e-06	2	60	2	34481515
Pubmed	cPGES/p23 is required for glucocorticoid receptor function and embryonic growth but not prostaglandin E2 synthesis.	PLA2G4A NR3C1 G6PC1	3.91e-06	18	60	3	17438133
Pubmed	Overexpression of mTOR and p(240-244)S6 in IDH1 Wild-Type Human Glioblastomas Is Predictive of Low Survival.	MTOR IDH1	8.77e-06	3	60	2	29328863
Pubmed	Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking.	CPT1C SACM1L	8.77e-06	3	60	2	32931550
Pubmed	MicroRNA-18a promotes cancer progression through SMG1 suppression and mTOR pathway activation in nasopharyngeal carcinoma.	SMG1 MTOR	8.77e-06	3	60	2	31659158
Pubmed	The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways.	SMG1 ATR	8.77e-06	3	60	2	15279777
Pubmed	5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.	SMG1 ATR MTOR	1.39e-05	27	60	3	23027611
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	SMG1 DIP2B ATR NR3C1 LMBRD2 CLSTN1 DICER1 SACM1L	1.55e-05	650	60	8	38777146
Pubmed	The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability.	MTOR SLC43A1	1.75e-05	4	60	2	25872869
Pubmed	Quantitative nuclear proteomics identifies mTOR regulation of DNA damage response.	ATR MTOR	1.75e-05	4	60	2	19955088
Pubmed	Induction of Galphas contributes to the paradoxical stimulation of cytosolic phospholipase A2alpha expression by cortisol in human amnion fibroblasts.	PLA2G4A NR3C1	1.75e-05	4	60	2	20203101
Pubmed	Caveolae facilitate TRPV4-mediated Ca2+ signaling and the hierarchical activation of Ca2+-activated K+ channels in K+-secreting renal collecting duct cells.	KCNMA1 KCNN3	1.75e-05	4	60	2	30207167
Pubmed	The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway.	MTOR IDH1	1.75e-05	4	60	2	27624942
Pubmed	Calcium-activated potassium channel expression in human myometrium: effect of pregnancy.	KCNMA1 KCNN3	1.75e-05	4	60	2	12434576
Pubmed	Dynamic coupling between TRPV4 and Ca2+-activated SK1/3 and IK1 K+ channels plays a critical role in regulating the K+-secretory BK channel in kidney collecting duct cells.	KCNMA1 KCNN3	2.92e-05	5	60	2	28274924
Pubmed	Glucocorticoids Drive Diurnal Oscillations in T Cell Distribution and Responses by Inducing Interleukin-7 Receptor and CXCR4.	NR3C1 IL7R	2.92e-05	5	60	2	29396162
Pubmed	Differential gene regulation of GHSR signaling pathway in the arcuate nucleus and NPY neurons by fasting, diet-induced obesity, and 17β-estradiol.	CPT1C UCP2	4.37e-05	6	60	2	26577678
Pubmed	Dicer ablation in osteoblasts by Runx2 driven cre-loxP recombination affects bone integrity, but not glucocorticoid-induced suppression of bone formation.	NR3C1 DICER1	8.14e-05	8	60	2	27554624
Pubmed	Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells.	MTOR IL7R	8.14e-05	8	60	2	20705244
Pubmed	International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels.	KCNMA1 KCNN3	8.14e-05	8	60	2	16382103
Pubmed	Risk alleles for multiple sclerosis identified by a genomewide study.	BRINP1 IL7R	8.14e-05	8	60	2	17660530
Pubmed	Asthma pharmacogenetic study using finite mixture models to handle drug-response heterogeneity.	PLA2G4A NR3C1	1.05e-04	9	60	2	19450127
Pubmed	The human RNA surveillance factor UPF1 is required for S phase progression and genome stability.	SMG1 ATR	1.05e-04	9	60	2	16488880
Pubmed	The mitochondrial transporter family SLC25: identification, properties and physiopathology.	SLC25A43 UCP2 MTCH1	1.08e-04	53	60	3	23266187
Pubmed	The functions of the HIV1 protein Vpr and its action through the DCAF1.DDB1.Cullin4 ubiquitin ligase.	ATR NR3C1	1.31e-04	10	60	2	20347598
Pubmed	Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukast.	PLA2G4A NR3C1	1.31e-04	10	60	2	17460547
Pubmed	Progesterone induced Warburg effect in HEK293 cells is associated with post-translational modifications and proteasomal degradation of progesterone receptor membrane component 1.	UBA1 ATR MTOR	1.41e-04	58	60	3	31067491
Pubmed	Light-entrained and brain-tuned circadian circuits regulate ILC3s and gut homeostasis.	NR3C1 IL7R	1.59e-04	11	60	2	31534216
Pubmed	An investigation into the human serum "interactome".	OR2T6 ABCA6 KCNMA1 DICER1	1.81e-04	162	60	4	15174051
Pubmed	Rheb binds and regulates the mTOR kinase.	ATR MTOR	1.91e-04	12	60	2	15854902
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	SLC6A8 UBA1 ATR SLC5A6 CPSF1 LMBRD2 CLSTN1 GNS SACM1L	2.05e-04	1201	60	9	35696571
Pubmed	Risk alleles for multiple sclerosis in multiplex families.	BRINP1 IL7R	2.26e-04	13	60	2	19506219
Pubmed	SNAT7 regulates mTORC1 via macropinocytosis.	MTOR SLC38A7	2.63e-04	14	60	2	35561222
Pubmed	Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway.	MTOR DICER1	2.63e-04	14	60	2	18988856
Pubmed	HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation.	KCNMA1 KCNN3	2.63e-04	14	60	2	10758170
Pubmed	Replication of CD58 and CLEC16A as genome-wide significant risk genes for multiple sclerosis.	BRINP1 IL7R	2.63e-04	14	60	2	19834503
Pubmed	Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients.	MTOR ECPAS	2.63e-04	14	60	2	28878358
Pubmed	Evolutionary origin of amino acid transporter families SLC32, SLC36 and SLC38 and physiological, pathological and therapeutic aspects.	SLC38A7 SLC36A2	3.03e-04	15	60	2	23506890
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	ATR MTOR ECPAS DICER1	4.18e-04	202	60	4	33005030
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	SLC6A8 DIP2B SYTL4 MTOR DTNA SLC43A1	4.42e-04	569	60	6	30639242
Pubmed	Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation.	NR3C1 G6PC1	4.91e-04	19	60	2	7628695
Pubmed	Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.	ATR MTOR	4.91e-04	19	60	2	20801936
Pubmed	An Ideal PPAR Response Element Bound to and Activated by PPARα.	PLPP5 MTOR	5.45e-04	20	60	2	26241474
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR2T6 OR2D3 OR4K3 OR4K14	5.66e-04	219	60	4	12213199
Pubmed	Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series.	MTOR IDH1 G6PC1	5.67e-04	93	60	3	27215380
Pubmed	Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	MON1B CLSTN1 SACM1L	7.01e-04	100	60	3	10048485
Pubmed	High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes.	CPT1C SACM1L	7.88e-04	24	60	2	22632720
Pubmed	Genetic variation in healthy oldest-old.	MTOR UCP2	7.88e-04	24	60	2	19680556
Pubmed	Hepatic Glucocorticoid Receptor Plays a Greater Role Than Adipose GR in Metabolic Syndrome Despite Renal Compensation.	NR3C1 G6PC1	7.88e-04	24	60	2	27754788
Pubmed	mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux.	UBA1 MTOR	8.56e-04	25	60	2	30340022
Pubmed	Lineage and stage specific requirement for Dicer1 in sympathetic ganglia and adrenal medulla formation and maintenance.	NR3C1 DICER1	8.56e-04	25	60	2	25661788
Pubmed	Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.	MTOR UCP2 NR3C1 G6PC1	9.27e-04	250	60	4	18660489
Pubmed	The MEV mouse linkage testing stock: mapping 30 novel proviral insertions and establishment of an improved stock.	IDH1 NR3C1	9.99e-04	27	60	2	8390965
Pubmed	Vpr and its interactions with cellular proteins.	ATR NR3C1	1.07e-03	28	60	2	20012529
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	MTOR SLC43A1 TMEM209 ECPAS CLSTN1 MTCH1 SACM1L	1.16e-03	942	60	7	31073040
Pubmed	The TIP60 Complex Is a Conserved Coactivator of HIF1A.	MTOR CPSF1 ECPAS	1.19e-03	120	60	3	27320910
Pubmed	Amino acid transport across mammalian intestinal and renal epithelia.	SLC43A1 SLC36A2	1.32e-03	31	60	2	18195088
Pubmed	Severe obesity is associated with novel single nucleotide polymorphisms of the ESR1 and PPARgamma locus in Han Chinese.	UCP2 NR3C1	1.40e-03	32	60	2	19491387
Pubmed	Determination of genetic predisposition to patent ductus arteriosus in preterm infants.	KCNN3 PLA2G4A NR3C1	1.46e-03	129	60	3	19336370
Pubmed	HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP.	MTCH1 DICER1	1.58e-03	34	60	2	25925205
GeneFamily	Solute carriers	SLC6A8 SLC25A43 SLC5A6 SLC43A1 UCP2 SLC38A7 SLC35G2 SLC4A5 MTCH1 SLC29A4 SLC36A2 SLC5A2	8.34e-11	395	43	12	752
GeneFamily	Potassium calcium-activated channels	KCNMA1 KCNN3	8.24e-05	6	43	2	255
Coexpression	DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_DN	SLC6A8 ATR SLC5A6 IDH1 CLSTN1 DICER1 GNS	2.24e-06	276	57	7	M3063
Drug	sodium	CACNA1S LIAS ATP11B MTOR SLC5A6 KCNMA1 KCNN3 SLC38A7 IDH1 NR3C1 SLC4A5 SLC29A4 SLC36A2 SLC5A2	9.40e-08	944	59	14	CID000000923
Drug	Cromoglicic acid	S100P KCNMA1	6.60e-06	2	59	2	DB01003
Drug	Niacinamide	MTOR UCP2 G6PC1 DICER1 TIPARP	1.32e-05	117	59	5	ctd:D009536
Drug	Lipoic Acid	LIAS SLC5A6	1.98e-05	3	59	2	DB00166
Drug	AN-8	LIAS NR3C1	1.98e-05	3	59	2	CID000055760
Drug	tetradecylthioacetic acid	LIAS CPT1C UCP2 KCNN3 NR3C1	2.04e-05	128	59	5	CID000114924
Drug	diazoxide	UCP2 KCNMA1 KCNN3 KCNG3 G6PC1 GNS	2.66e-05	227	59	6	CID000003019
Drug	tetraethylammonium	CACNA1S MTOR KCNMA1 KCNN3 KCNG3 SLC29A4	3.31e-05	236	59	6	CID000005413
Drug	Fluticasone Propionate	PLA2G4A NR3C1	3.95e-05	4	59	2	DB00588
Disease	Infiltrating duct carcinoma of female breast	SMG1 MAK ATR EPHA10	7.31e-08	21	57	4	C3165106
Disease	Duchenne muscular dystrophy (implicated_via_orthology)	CACNA1S DTNA KCNMA1	4.66e-05	36	57	3	DOID:11723 (implicated_via_orthology)
Disease	hypertension (implicated_via_orthology)	MTOR UCP2 NR3C1 SLC5A2	1.12e-04	128	57	4	DOID:10763 (implicated_via_orthology)
Disease	Osteopenia	SLC5A6 KCNMA1	3.79e-04	15	57	2	C0029453
Disease	Giant Cell Glioblastoma	MTOR TMEM135 IDH1	5.83e-04	84	57	3	C0334588
Disease	polycystic kidney disease (biomarker_via_orthology)	MTOR PLA2G4A	6.14e-04	19	57	2	DOID:0080322 (biomarker_via_orthology)
Disease	middle cerebral artery infarction (biomarker_via_orthology)	MTOR DICER1 IL7R	7.84e-04	93	57	3	DOID:3525 (biomarker_via_orthology)
Disease	type 2 diabetes mellitus (implicated_via_orthology)	UCP2 NR3C1 G6PC1	1.11e-03	105	57	3	DOID:9352 (implicated_via_orthology)
Disease	Glioblastoma Multiforme	MTOR TMEM135 IDH1	1.31e-03	111	57	3	C1621958
Disease	Schizoaffective Disorder	PLA2G4A NR3C1	1.44e-03	29	57	2	C0036337
Disease	Autistic Disorder	SLC6A8 KCNMA1 PLA2G4A HTR3C	1.64e-03	261	57	4	C0004352
Disease	Large cell carcinoma of lung	ATR MTOR	1.75e-03	32	57	2	C0345958
Disease	fatty liver disease (biomarker_via_orthology)	UCP2 G6PC1	1.86e-03	33	57	2	DOID:9452 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
FLMILGTESYTSTAM	CATSPERG	461	Q6ZRH7
ISATLGGEEALTMYM	BRINP1	131	O60477
GDSYTMIATFSMLLL	ABCA6	391	Q8N139
SSFLYTVDSMLLGMD	HTR3C	181	Q8WXA8
GMTFTGVDTMASYEE	CLSTN1	756	O94985
AGAIYMDSGMSLETV	DICER1	1816	Q9UPY3
MFLAKVLTGRYTMGS	TIPARP	586	Q7Z3E1
WVIISMTTVGYGDMY	KCNG3	366	Q8TAE7
YGSVEALSATMGVMT	MON1B	126	Q7L1V2
GFMTGTISSMYQTKA	TMBIM1	176	Q969X1
LMVTMSTVGYGDVYA	KCNMA1	346	Q12791
TLMALMIGSYASSAI	SLC43A1	166	O75387
TTSMVTMEPGYLFLG	CPSF1	371	Q10570
EALSMMVGAYSTLEG	ECPAS	461	Q5VYK3
TEIAMSSCKYSGGVM	KCNN3	171	Q9UGI6
MLVDYLMGEGTISFI	OR2T6	81	Q8NHC8
DTYILGVFMISTSGM	OR4K3	191	Q96R72
MDTYVLGIIMISDSG	OR4K14	191	Q8NGD5
SLGIFYMVVSSGVDM	FAM210B	111	Q96KR6
EMLAYLDFSVSTTGM	DIP2B	1151	Q9P265
GEYATATATIMLMGD	LIAS	121	O43766
AVSLSMGLYMGETET	NR3C1	81	P04150
MTILGTTFGMVFSLL	IL7R	1	P16871
GSTLMIVTEYMSHGA	EPHA10	716	Q5JZY3
IDTYSTEMAIFSMGV	OR2D3	206	Q8NGH3
GSHLTAVAMMYGTLI	OR5C1	246	Q8NGR4
EMKAFLGYMISTSIS	PGBD5	166	Q8N414
YIFMGDGMITFHISS	CPT1C	721	Q8TCG5
TAVMSMVGYILGLGD	ATR	2461	Q13535
VAQGYGSLGMMTSVL	IDH1	281	O75874
LSAMMSLFTVSTFEG	CACNA1S	1001	Q13698
MGTAGVYYVMVTSTL	G6PC1	121	P35575
TMRQLGDGTYGSVLM	MAK	6	P20794
KALIGEMGMTFSSAY	GNS	71	P15586
IFSMISDSSGVMVYG	DTNA	151	Q9Y4J8
FATMVSSLGSGMMRY	SACM1L	321	Q9NTJ5
AMVGFSGVMKALYES	PLA2G4A	201	P47712
TRSLAVMSMVGYILG	MTOR	2321	P42345
SYTKFVMGIAVSMLT	MTCH1	311	Q9NZJ7
STIGSMMSIYSEAGD	SYTL4	336	Q96C24
AYTSIMGSMKVLSFI	LMBRD2	511	Q68DH5
GTSVGMSTFSIMDYV	SLC5A6	16	Q9Y289
FGYTMTVMAGLTTAL	SLC35G2	256	Q8TBE7
TMTSSLYFITFGMGA	PTCHD4	341	Q6ZW05
TAVMSMVGYIIGLGD	SMG1	2321	Q96Q15
LGMSIVTSLYIGMAA	SLC36A2	301	Q495M3
TAAMVIALAVYMGTG	SLC38A7	281	Q9NVC3
VIDLSMVTDGGMYVF	SLC6A8	456	P48029
MAGSLAGMVSTIVTY	SLC25A43	111	Q8WUT9
MGFATIMGSMSSVIY	CNGA4	256	Q8IV77
FGVAVYTGMETKMAL	ATP11B	256	Q9Y2G3
SAQYRGVMGTILTMV	UCP2	56	P55851
MIYTVTGGLAALMYT	SLC5A2	186	P31639
QDVLVGSMIGMTFAY	PLPP5	211	Q8NEB5
LAGISMMFYKSTTIS	TMEM135	336	Q86UB9
MSFILFFGTYSMTLT	SLC4A5	746	Q9BY07
TAMGMIIDVFSRYSG	S100P	6	P25815
EITMLSQGVSMLYSF	UBA1	986	P22314
GMIYTEMTGKLISSY	TMEM209	41	Q96SK2
ELAGNTMTVSYMSGL	SLC29A4	481	Q7RTT9
TMTVSYMSGLTLGSA	SLC29A4	486	Q7RTT9