Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionstructural constituent of nuclear pore

POM121 NPAP1 POM121C

1.15e-0425763GO:0017056
GeneOntologyMolecularFunctionnuclear localization sequence binding

POM121 NPAP1 POM121C

1.45e-0427763GO:0008139
GeneOntologyCellularComponentinterstitial matrix

ABI3BP ECM2 VWA1

2.91e-0517753GO:0005614
PathwayPID_RHOA_REG_PATHWAY

ARHGAP6 MYO9B ARHGEF5 ARHGEF15

3.00e-0546554M68
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

KMT2B SYNJ1 MYO9B PPRC1 ZNF335 GPC2 SRCAP POM121C BIRC6 PLEKHG5 AGRN KIFC2 ANO8

1.02e-061105781335748872
Pubmed

Proteins recruited by SH3 domains of Ruk/CIN85 adaptor identified by LC-MS/MS.

SRRM1 POM121 WIPF1 SYNJ1 ATXN2

4.64e-0610878519531213
Pubmed

P2Y2 receptor transcription is increased by NF-kappa B and stimulates cyclooxygenase-2 expression and PGE2 released by intestinal epithelial cells.

P2RY2 RELA

4.97e-06278219734210
Pubmed

The kinesin-14 family motor protein KIFC2 promotes prostate cancer progression by regulating p65.

RELA KIFC2

4.97e-06278237716704
Pubmed

A dual role for the RhoGEF Ephexin5 in regulation of dendritic spine outgrowth.

ARHGEF5 ARHGEF15

4.97e-06278228185854
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

ARHGAP6 ZNF469 POM121 SPATA31E1 ATXN2 ARHGEF5 POM121C GAB1

5.63e-0643078835044719
Pubmed

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

GTF3A KMT2B WIPF1 PRICKLE3 DNM3 SELENON KIFC2

9.45e-0632978717474147
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

ESYT2 SYNJ1 DNM3 AUTS2 BIRC6 ARHGEF15

1.19e-0522578612168954
Pubmed

A human MAP kinase interactome.

POM121 WIPF1 ABI3BP TCERG1 MAP3K10 RELA POM121C GAB1

1.37e-0548678820936779
Pubmed

POM121 inhibits the macrophage inflammatory response by impacting NF-κB P65 nuclear accumulation.

POM121 POM121C

1.49e-05378230802453
Pubmed

Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine.

POM121 POM121C

1.49e-05378235507432
Pubmed

Heterologous down-regulation of angiotensin type 1 receptors by purinergic P2Y2 receptor stimulation through S-nitrosylation of NF-kappaB.

P2RY2 RELA

1.49e-05378221464294
Pubmed

Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9.

SYNJ1 DNM3

1.49e-05378235065714
Pubmed

Reducing expression of synapse-restricting protein Ephexin5 ameliorates Alzheimer's-like impairment in mice.

ARHGEF5 ARHGEF15

1.49e-05378228346227
Pubmed

Exosomal miR-221 targets DNM3 to induce tumor progression and temozolomide resistance in glioma.

DNM3 RELA

1.49e-05378227837435
Pubmed

Two distinct human POM121 genes: requirement for the formation of nuclear pore complexes.

POM121 POM121C

2.97e-05478217900573
Pubmed

Kif5B and Kifc1 interact and are required for motility and fission of early endocytic vesicles in mouse liver.

KIFC2 KIF1C

2.97e-05478217360972
Pubmed

Transcriptome-based systematic identification of extracellular matrix proteins.

ABI3BP ECM2 VWA1 AGRN

3.10e-057978418757743
Pubmed

Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats.

ARID1B ATXN2

7.40e-0567828896557
Pubmed

PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5.

ARHGEF5 ARHGEF15

7.40e-05678230485813
Pubmed

Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.

WIPF1 SYNJ1 DNM3 GAB1

8.74e-0510378421706016
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TTBK1 POM121 POM121C BIRC6 ARHGEF15 ANO8 KIF1C

1.22e-0449378715368895
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

SRRM1 ESYT2 TCERG1 SYNJ1 ARHGEF5 MAP3K10 PROSER2 GAB1 KIF1C

1.33e-0486178936931259
Pubmed

Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking.

ATXN2 DNM3

1.38e-04878218602463
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

POM121 TCERG1 ATXN2 ZNF318 POM121C

3.20e-0426378534702444
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

SRRM1 ESYT2 KMT2B PRICKLE3 ZNF335 ZNF318 PROSER2 ZNF551

3.45e-0477478815302935
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

TCERG1 SYNJ1 MYO9B TPRN ZNF318 SRCAP GAB1

3.57e-0458878738580884
Pubmed

EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation.

ARHGEF5 ARHGEF15

3.81e-041378221029865
Pubmed

Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.

AUTS2 PAX1

3.81e-041378222693459
Pubmed

The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.

ARID1B KMT2B AUTS2 SRCAP

4.40e-0415778430186101
Pubmed

Spatiotemporal Localisation of Heparan Sulphate Proteoglycans throughout Mouse Lens Morphogenesis.

GPC2 AGRN

4.44e-041478237408198
Pubmed

Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains.

KMT2B TCERG1

4.44e-04147828605874
Pubmed

Proteomic analysis identifies transcriptional cofactors and homeobox transcription factors as TBX18 binding proteins.

PBX4 PAX1

5.12e-041578230071041
Pubmed

Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.

POM121 POM121C

5.12e-041578214697343
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

ARID1B POM121 ATXN2 AUTS2 MTX1 POM121C

5.76e-0445778632344865
Pubmed

Bioinformatics and cellular signaling.

WIPF1 PPRC1 RELA GAB1

7.65e-0418278415102471
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

SRRM1 ZNF469 ARID1B TPRN MMP21 ZNF318 SRCAP POM121C PSMG3-AS1

8.76e-04111678931753913
Pubmed

Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.

SRRM1 KMT2B TCERG1 SYNJ1 ZNF318 SRCAP

9.76e-0450678630890647
Pubmed

Altered heparan sulfate structure in Glce(-/-) mice leads to increased Hedgehog signaling in endochondral bones.

GPC2 AGRN

1.01e-032178226116392
Pubmed

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.

SRRM1 ARHGAP6 TCERG1 PRR36 ARHGEF5 DNM3 PLEKHG5 ARHGEF15

1.04e-0391678832203420
Pubmed

Tissue-Specific Gain of RTK Signalling Uncovers Selective Cell Vulnerability during Embryogenesis.

GPC2 GAB1

1.44e-032578226393505
Pubmed

Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome.

KIFC2 KIF1C

1.44e-03257829275178
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

ARID1B KMT2B TCERG1 SYNJ1 ZNF318 SRCAP

1.48e-0354978638280479
Pubmed

Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

SYNJ1 DNM3 ARHGEF15

1.50e-0310078310048485
Pubmed

Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

ESYT2 ARID1B BIRC6

1.63e-0310378310574462
Pubmed

Parkinson Disease Overview

SYNJ1 ATXN2

1.68e-032778220301402
Pubmed

Eda-activated RelB recruits an SWI/SNF (BAF) chromatin-remodeling complex and initiates gene transcription in skin appendage formation.

ARID1B RELA

1.81e-032878230037996
Pubmed

Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

ZNF469 TTBK1 HHIPL1

1.82e-0310778311347906
Pubmed

The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing.

POM121 POM121C

1.94e-032978217577209
Pubmed

Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.

SRRM1 TCERG1 ATXN2 ZNF318 PROSER2

2.06e-0339978535987950
Pubmed

The Tumor Suppressor SASH1 Interacts With the Signal Adaptor CRKL to Inhibit Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer.

AKAP10 GAB1

2.07e-033078230480076
Pubmed

Functional analysis of secreted and transmembrane proteins critical to mouse development.

BIRC6 AGRN

2.21e-033178211431694
Cytoband10q24.32

PPRC1 C10orf95

7.87e-042479210q24.32
Cytoband7q36.3

ESYT2 NOM1

7.87e-04247927q36.3
Cytoband7p22.3

MICALL2 PSMG3-AS1

1.58e-03347927p22.3
Cytoband17q25

GRIN2C RFNG

2.08e-033979217q25
CytobandEnsembl 112 genes in cytogenetic band chr7q36

ESYT2 NOM1 WDR86

2.66e-03159793chr7q36
ToppCellfacs-Lung-EPCAM-3m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KMT2B NOM1 DNM3 PROSER2 AGRN

1.03e-051647851d0d88132baaa3154c3e6e4ef0aff795afab08a2
ToppCellfacs-Lung-EPCAM-3m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KMT2B NOM1 DNM3 PROSER2 AGRN

1.03e-05164785bd2e10b015d5e6a338675500ec5d81dc39583b3e
ToppCellfacs-Kidney-nan-3m-Mesenchymal-mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP ECM2 WDR86 HHIPL1 PROSER2

2.04e-05189785a5306561026e4dfcc39beeb785e5108ac595d136
ToppCellfacs-Kidney-nan-3m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP ECM2 WDR86 HHIPL1 PROSER2

2.04e-05189785381058f55908f84375b54601d617389ef43ab855
ToppCellfacs-Kidney-nan-3m-Mesenchymal-mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABI3BP ECM2 WDR86 HHIPL1 PROSER2

2.04e-05189785302b950a6ad578f8aeff7ea6fd15fe631225287d
ToppCell(4)_Endothelial_cells-(40)_EC-arterial|(4)_Endothelial_cells / Cell class and subclass of bone marrow stroma cells in homeostatis

CENPT P2RY2 ECM2 DNM3 LYSMD2

2.10e-05190785ff774faf3f12759d11e50ed7d189288bb79e22e1
ToppCell3'-Adult-LargeIntestine-Hematopoietic-T_cells-CD8_Tmem|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CCDC194 WIPF1 ZNF575 PBX4 ZFP92

2.20e-05192785c1e2a7df7809696c482442665af5c6bb2f0e5bea
ToppCellMesenchymal_cells-Arteriolar_fibro.|World / Lineage and Cell class

SSC5D ABI3BP ECM2 LYSMD2 PAX1

2.32e-05194785c1e8923a50b4138a1e4c054c0c17b7f7122aa8a9
ToppCell(3)_Chondrocytes-(34)_Chondro-progen|(3)_Chondrocytes / Cell class and subclass of bone marrow stroma cells in homeostatis

ABI3BP ECM2 C11orf96 VWA1 PROSER2

2.49e-05197785012c49a57f9c2a3dfa988cd3882c8c6b7ef3a5ad
ToppCelldistal-1-mesenchymal-Lipofibroblast|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

ZNF469 ABI3BP ECM2 WDR86 ANKRD53

2.61e-05199785a8293db3c42a8d30897858b49aae7acfc18663ba
Diseasemean platelet volume

RASSF5 SRRM1 ESYT2 WIPF1 P2RY2 ATXN2 PRICKLE3 MYO9B DNM3 AKAP10 BIN2 PROSER2 SRCAP

1.62e-0610207513EFO_0004584
Diseaseimmature platelet fraction

RASSF5 ESYT2 MYO9B DNM3 BIN2

1.10e-05114755EFO_0009187
Diseasetestosterone measurement

ARHGAP6 ARID1B TTBK1 P2RY2 MYO9B TPRN DNM3 AUTS2 ZNF318 HHIPL1 SRCAP BIRC6 ARHGEF15

1.80e-0512757513EFO_0004908
Diseaseeye measurement

ZNF469 TRAF3IP1 ATXN2

4.42e-0527753EFO_0004731
Diseasespleen volume

ATXN2 MYO9B KIF1C

1.81e-0443753EFO_0600047
Diseaseimmature platelet measurement

RASSF5 MYO9B DNM3 BIN2

2.45e-04119754EFO_0803541
Diseasemean arterial pressure

TTBK1 ATXN2 MYO9B AUTS2 ZNF318 MTX1 POM121C

2.79e-04499757EFO_0006340
Diseaseaspartate aminotransferase to alanine aminotransferase ratio

ATXN2 DNM3 AUTS2 PBX4 KIFC2

3.64e-04239755EFO_0010934
DiseaseAntihypertensive use measurement

SRRM1 ATXN2 MYO9B AUTS2 ZNF318

5.82e-04265755EFO_0009927
Diseaseanthropometric measurement

ZNF469 TRAF3IP1 ATXN2 DNM3

9.00e-04168754EFO_0004302
DiseaseC-X-C motif chemokine 16 measurement

ZMYND15 ATXN2

9.50e-0418752EFO_0010911
Diseaseplatelet measurement

RASSF5 ESYT2 MYO9B DNM3 BIN2

1.26e-03315755EFO_0005036
Diseasereticulocyte count

RASSF5 ZNF469 P2RY2 ATXN2 MYO9B PLEKHA4 AKAP10 BIRC6 KIF1C

1.31e-031045759EFO_0007986
Diseaseblood tin measurement

ABI3BP ARTN

1.84e-0325752EFO_0021530
DiseaseCalcium channel blocker use measurement

TTBK1 ATXN2 ZNF318 MTX1

2.15e-03213754EFO_0009930
Diseaseimmature platelet count

ESYT2 DNM3 BIN2

2.52e-03106753EFO_0803544

Protein segments in the cluster

PeptideGeneStartEntry
RRRPRLPAASPAPSP

FAM246C

156

P0DSO1
LSRPGSARAPSPPRP

ESYT2

81

A0FGR8
TPPRPPSRRGRTIPD

BIRC6

3931

Q9NR09
PSPRQSPRTLRPDPG

AKAP10

6

O43572
PRPRRRPRPPAGSPA

DUSP8

451

Q13202
PPPLPPKSRGRSRST

ARHGEF5

851

Q12774
PTTAPSRVPGRRPPA

AGRN

1311

O00468
PPRIIRPRPPSRSRA

ARHGEF15

16

O94989
PPRRRPPPPLSSAGR

ARID1B

1911

Q8NFD5
RPPPPRATASPRPSS

BIN2

416

Q9UBW5
ALRTRRSRSPAPPPP

ANO8

1121

Q9HCE9
EPPPRASRPARPLRP

RASSF5

71

Q8WWW0
ARTPAPAPRAPPSRP

RFNG

36

Q9Y644
RPRRPASLTPPRADP

ANKRD53

76

Q8N9V6
RRIPRPGSARPAPPR

TRAF3IP1

456

Q8TDR0
PARRRPPEFPGRPTT

MAP3K10

866

Q02779
RAPRPSAPSPPPRSR

LYSMD2

16

Q8IV50
LRPPASPCPPRPRRG

PSMG3-AS1

56

Q96PY0
PTRAPRRGRPTAAPP

HHIPL1

621

Q96JK4
RRGRPTAAPPAPTPR

HHIPL1

626

Q96JK4
ARPPRPPYPPRRDGS

GPC2

521

Q8N158
GFRSSPKTPPRRPVP

GAB1

496

Q13480
GRARRPPPQPSRPAP

ARTN

76

Q5T4W7
PRAATPTRPPSRPPS

ATXN2

576

Q99700
PTRPPSRPPSRPSRP

ATXN2

581

Q99700
PRPRSGSRPRPSPRS

CCDC194

201

A0A1B0GVG4
SRPTRAPPSVPSRRP

DNM3

836

Q9UQ16
GPSLPARSPSPPRRR

MICALL2

651

Q8IY33
PSPPGPPPRARSRRS

MMP21

131

Q8N119
PPPRARSRRSPRAPL

MMP21

136

Q8N119
PPPPPRPRARGASRR

NRG2

721

O14511
KPPSSAPSRPRPPRR

AUTS2

61

Q8WXX7
PHPATPARRPPSPRR

KIF1C

1011

O43896
FPAPPRRSRRPSPLA

KMT2B

1906

Q9UMN6
RRSRRPSPLAPRPPP

KMT2B

1911

Q9UMN6
KPPTGPSPATPARRR

P2RY2

321

P41231
RRPPARPAPRSTPPS

POM121C

151

A8CG34
SSSRGPPPRATRLPP

ARHGAP6

81

O43182
SAPPAQRRRPRSPPP

PRICKLE3

491

O43900
RPGRRPPARPAPRSP

POM121

161

Q96HA1
RPAPSPPAPRRLDTS

PBX4

6

Q9BYU1
DCPSRPRPPRGSSPR

PAX1

446

P15863
PPRPRTTGPRPRQDP

CENPT

441

Q96BT3
PSRSPLPAPPRGTLR

ECM2

301

O94769
RPPRSRPRWGQSPPP

PPRC1

226

Q5VV67
PTRARPPAPLARRSP

KIFC2

721

Q96AC6
PRRTRPRSPEPAAPS

MTX1

36

Q13505
SRSRAPAPPVPPRDP

RUSC1

376

Q9BVN2
IRPSRAPSRTPGPPS

SYNJ1

1066

O43426
PRPRSAPARRPPAPS

PLEKHA4

246

Q9H4M7
LSRPPTPRRGPPSEA

PLEKHA4

291

Q9H4M7
STPDPPRRELRAPSP

PROSER2

166

Q86WR7
RPAPSARPRPPTEGP

PRR36

191

Q9H6K5
PSPPPGRKRSSREPQ

SPATA31E1

91

Q6ZUB1
RPAPSRDPSPPRKPR

NOM1

131

Q5C9Z4
PEGPSPARPPRRRTS

SRCAP

2711

Q6ZRS2
ERRPPRPAATRTAPP

SSC5D

991

A1L4H1
PPRSAAPPRAARNRP

NPAP1

311

Q9NZP6
ASTAPPRHPRPRRPG

C10orf95

106

Q9H7T3
PPARPPSRGAPARAR

C11orf96

251

Q7Z7L8
RPRPRPVPRAPTPGT

VWA1

426

Q6PCB0
SPRVPSPPPSPRLRR

PLEKHG5

846

O94827
PPRPSTAARPSRPSR

ZFP92

401

A6NM28
RPPAPRSPRLPASTS

TTBK1

1226

Q5TCY1
RGPPPPPTASEPTRR

TCERG1

1081

O14776
SASPPRRRHRPSPPA

SRRM1

391

Q8IYB3
SPRGRRRRSPSPPPT

SRRM1

541

Q8IYB3
SPPPTRRRRSPSPAP

SRRM1

551

Q8IYB3
PPRRRTPSPPPRRRS

SRRM1

576

Q8IYB3
TPSPPPRRRSPSPRR

SRRM1

581

Q8IYB3
PRRRSPSPRRYSPPI

SRRM1

586

Q8IYB3
SAGSPPRPRRRPPPQ

ZNF575

46

Q86XF7
PAAQPPAPPRRRARS

SELENON

16

Q9NZV5
PTRKPPRASPRTPSR

nan

71

Q9UF83
TRTPPRASPTRRPPR

nan

196

Q9UF83
RRPPRASPTRTPPRE

nan

206

Q9UF83
TRMPPRASPTRRPPR

nan

231

Q9UF83
RRPPRASPTGSPPRA

nan

241

Q9UF83
MPAPVGRRSPPSPRS

ZNF551

1

Q7Z340
RSGPRPPLPPDRPSA

WIPF1

411

O43516
STPPPPLPRRRSRAR

nan

51

Q8N1X5
PPRPRRPRTQAPGSR

ZNF469

991

Q96JG9
PSLRSSPGPAPRVPR

TMEM245

11

Q9H330
PSPTSPSPTLGRRRP

TMEM245

326

Q9H330
PRRRGSPERARPPPP

TPRN

146

Q4KMQ1
SSAPTPPRPALPRRF

GTF3A

26

Q92664
RSTYRPRPRRSVPPP

XAGE3

6

Q8WTP9
GTRRPPLPPRPTHPR

ABI3BP

696

Q7Z7G0
SPFSGPTDPRPPPRR

RELA

316

Q04206
TPSTPRPRRRPGRPR

ZNF335

341

Q9H4Z2
RGAPRPPPPMRSLSR

WDR86

346

Q86TI4
PTPSAPPAPTRRRRG

ZMYND15

716

Q9H091
SPPRGRRVSPSPPRA

ZNF318

71

Q5VUA4
APPRTTTRRPPRPPG

TMEM108

156

Q6UXF1
PLPTVAAPPRRRPSS

MYO9B

2036

Q13459
GRRAPPPSPCPTPRS

GRIN2C

926

Q14957