Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA cap binding	LARP1 CYFIP1 LARP1B	1.38e-05	21	45	3	GO:0000339
GeneOntologyMolecularFunction	RNA 7-methylguanosine cap binding	LARP1 CYFIP1	4.44e-04	14	45	2	GO:0000340
GeneOntologyCellularComponent	intraciliary transport particle	IFT172 TTC21A IFT81	2.75e-05	28	44	3	GO:0030990
GeneOntologyCellularComponent	SCF ubiquitin ligase complex	CUL5 CCNF CUL2	4.32e-04	70	44	3	GO:0019005
Domain	DM15	LARP1 LARP1B	5.42e-06	2	44	2	SM00684
Domain	DM15	LARP1 LARP1B	5.42e-06	2	44	2	IPR006607
Domain	Cullin_CS	CUL5 CUL2	1.13e-04	7	44	2	IPR016157
Domain	La	LARP1 LARP1B	1.13e-04	7	44	2	PF05383
Domain	CULLIN	CUL5 CUL2	1.13e-04	7	44	2	SM00182
Domain	Lupus_La_RNA-bd	LARP1 LARP1B	1.13e-04	7	44	2	IPR006630
Domain	LA	LARP1 LARP1B	1.13e-04	7	44	2	SM00715
Domain	HTH_LA	LARP1 LARP1B	1.13e-04	7	44	2	PS50961
Domain	Cullin_Nedd8	CUL5 CUL2	1.51e-04	8	44	2	PF10557
Domain	Cullin_Nedd8	CUL5 CUL2	1.51e-04	8	44	2	SM00884
Domain	Cullin_neddylation_domain	CUL5 CUL2	1.51e-04	8	44	2	IPR019559
Domain	Cullin_homology	CUL5 CUL2	1.93e-04	9	44	2	IPR016158
Domain	Cullin_N	CUL5 CUL2	2.41e-04	10	44	2	IPR001373
Domain	Cullin	CUL5 CUL2	2.41e-04	10	44	2	PF00888
Domain	CULLIN_2	CUL5 CUL2	2.41e-04	10	44	2	PS50069
Domain	CULLIN_1	CUL5 CUL2	2.41e-04	10	44	2	PS01256
Domain	Cullin_repeat-like_dom	CUL5 CUL2	3.53e-04	12	44	2	IPR016159
Domain	zf-C2H2_6	PLAGL2 ZNF695 ZNF155 RREB1 ZNF445	8.26e-04	314	44	5	PF13912
Domain	-	CUL5 CUL2 LARP1 LARP1B	1.70e-03	218	44	4	1.10.10.10
Domain	TPR-like_helical_dom	CCNF KIFBP IFT172 TTC21A	2.17e-03	233	44	4	IPR011990
Domain	WHTH_DNA-bd_dom	CUL5 CUL2 LARP1 LARP1B	2.49e-03	242	44	4	IPR011991
Domain	CYCLIN	CCNF RBL2	3.61e-03	38	44	2	SM00385
Domain	-	CCNF RBL2	4.00e-03	40	44	2	1.10.472.10
Domain	Cyclin-like	CCNF RBL2	4.61e-03	43	44	2	IPR013763
Domain	-	PLAGL2 ZNF695 ZNF155 RREB1 KLF5 ZNF445	4.91e-03	679	44	6	3.30.160.60
Domain	zf-C2H2	PLAGL2 ZNF695 ZNF155 RREB1 KLF5 ZNF445	5.42e-03	693	44	6	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	PLAGL2 ZNF695 ZNF155 RREB1 KLF5 ZNF445	5.46e-03	694	44	6	IPR013087
Domain	ZINC_FINGER_C2H2_2	PLAGL2 ZNF695 ZNF155 RREB1 KLF5 ZNF445	9.21e-03	775	44	6	PS50157
Domain	ZINC_FINGER_C2H2_1	PLAGL2 ZNF695 ZNF155 RREB1 KLF5 ZNF445	9.32e-03	777	44	6	PS00028
Domain	Znf_C2H2-like	PLAGL2 ZNF695 ZNF155 RREB1 KLF5 ZNF445	1.04e-02	796	44	6	IPR015880
Domain	Znf_C2H2	PLAGL2 ZNF695 ZNF155 RREB1 KLF5 ZNF445	1.10e-02	805	44	6	IPR007087
Domain	ZnF_C2H2	PLAGL2 ZNF695 ZNF155 RREB1 KLF5 ZNF445	1.12e-02	808	44	6	SM00355
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	MKLN1 TLK2 CUL2 LARP1 KIFBP TSC2 TLK1 CYFIP1 RREB1 IFT172 CNP TTC21A IFT81 RAB11FIP2	6.73e-10	1321	45	14	27173435
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	MKLN1 CUL5 TLK2 CUL2 LARP1 MSH6 KIFBP TSC2 TLK1 SRRM2 RAB11FIP2	5.32e-07	1284	45	11	17353931
Pubmed	The expression of Tousled kinases in CaP cell lines and its relation to radiation response and DSB repair.	TLK2 TLK1	1.64e-06	2	45	2	21647934
Pubmed	Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres.	TLK2 TLK1	1.64e-06	2	45	2	32755577
Pubmed	cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal.	TLK2 TLK1	1.64e-06	2	45	2	9427565
Pubmed	Combinatorial CRISPR screen identifies fitness effects of gene paralogues.	TLK2 LARP1 TLK1 LARP1B SRRM2	4.26e-06	186	45	5	33637726
Pubmed	Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation.	TLK2 TLK1	4.91e-06	3	45	2	28535374
Pubmed	Identification of NEDD8-conjugation site in human cullin-2.	CUL5 CUL2	4.91e-06	3	45	2	10092517
Pubmed	The TLK-ASF1 histone chaperone pathway plays a critical role in IL-1β-mediated AML progression.	TLK2 TLK1	4.91e-06	3	45	2	38498025
Pubmed	Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases.	TLK2 TLK1	9.81e-06	4	45	2	11470414
Pubmed	The role of fatty acid β-oxidation in lymphangiogenesis.	CPT1A PROX1	9.81e-06	4	45	2	28024299
Pubmed	Functional Dissection of the CCBE1 Protein: A Crucial Requirement for the Collagen Repeat Domain.	CCBE1 PROX1	9.81e-06	4	45	2	25814692
Pubmed	Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication.	TLK2 TLK1	9.81e-06	4	45	2	10523312
Pubmed	Phosphorylation-mediated control of histone chaperone ASF1 levels by Tousled-like kinases.	TLK2 TLK1	9.81e-06	4	45	2	20016786
Pubmed	Ccbe1 expression marks the cardiac and lymphatic progenitor lineages during early stages of mouse development.	CCBE1 PROX1	9.81e-06	4	45	2	22252499
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	TLK2 KDM3B LARP1 MSH6 PLAGL2 TLK1 RREB1 SRRM2 KLF5	9.96e-06	1103	45	9	34189442
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	LARP1 KIFBP RREB1 RBL2 CECR2 CNP	1.21e-05	398	45	6	35016035
Pubmed	Tousled-like kinase in a microbial eukaryote regulates spindle assembly and S-phase progression by interacting with Aurora kinase and chromatin assembly factors.	TLK2 TLK1	1.63e-05	5	45	2	17940067
Pubmed	Cullin 5 regulates Dab1 protein levels and neuron positioning during cortical development.	CUL5 CUL2	1.63e-05	5	45	2	17974915
Pubmed	CCBE1 is essential for mammalian lymphatic vascular development and enhances the lymphangiogenic effect of vascular endothelial growth factor-C in vivo.	CCBE1 PROX1	1.63e-05	5	45	2	21778431
Pubmed	Structural basis for hijacking CBF-β and CUL5 E3 ligase complex by HIV-1 Vif.	CUL5 CUL2	1.63e-05	5	45	2	24402281
Pubmed	Distinct origins and molecular mechanisms contribute to lymphatic formation during cardiac growth and regeneration.	CCBE1 PROX1	1.63e-05	5	45	2	31702554
Pubmed	Lysine acetylation targets protein complexes and co-regulates major cellular functions.	LARP1 TSC2 SRRM2	1.65e-05	38	45	3	19608861
Pubmed	Differential dynamics of cullin deneddylation via COP9 signalosome subunit 5 interaction.	CUL5 CUL2	2.45e-05	6	45	2	36423380
Pubmed	cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.	CUL5 CUL2	2.45e-05	6	45	2	8681378
Pubmed	Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint.	TLK2 TLK1	2.45e-05	6	45	2	12660173
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	CUL2 MSH6 EVPL CYFIP1 CPT1A SRRM2 IFT172 CNP	3.16e-05	974	45	8	28675297
Pubmed	Basis for metabolite-dependent Cullin-RING ligase deneddylation by the COP9 signalosome.	CUL5 CUL2	3.42e-05	7	45	2	32047038
Pubmed	Activation of UBC5 ubiquitin-conjugating enzyme by the RING finger of ROC1 and assembly of active ubiquitin ligases by all cullins.	CUL5 CUL2	3.42e-05	7	45	2	11861641
Pubmed	Functional analysis of an individual IFT protein: IFT46 is required for transport of outer dynein arms into flagella.	IFT172 IFT81	3.42e-05	7	45	2	17312020
Pubmed	De novo DNA methyltransferase DNMT3b interacts with NEDD8-modified proteins.	CUL5 CUL2	3.42e-05	7	45	2	20847044
Pubmed	The functional interactome landscape of the human histone deacetylase family.	MSH6 CPT1A RREB1 SRRM2 HDAC8	3.56e-05	289	45	5	23752268
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	CUL2 LARP1 MSH6 CYFIP1 CADPS CNP	4.24e-05	498	45	6	36634849
Pubmed	ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation.	CUL5 CUL2	4.56e-05	8	45	2	27697924
Pubmed	ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism.	CUL5 CUL2	4.56e-05	8	45	2	17636018
Pubmed	EC5S ubiquitin complex is recruited by KSHV latent antigen LANA for degradation of the VHL and p53 tumor suppressors.	CUL5 CUL2	4.56e-05	8	45	2	17069461
Pubmed	Covalent modification of all members of human cullin family proteins by NEDD8.	CUL5 CUL2	4.56e-05	8	45	2	10597293
Pubmed	Epigenetic modulator inhibition overcomes temozolomide chemoresistance and antagonizes tumor recurrence of glioblastoma.	CUL5 CUL2	4.56e-05	8	45	2	33016927
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	TLK2 KDM3B LARP1 MSH6 TLK1 RREB1 SRRM2	5.72e-05	774	45	7	15302935
Pubmed	Proteolytic activation defines distinct lymphangiogenic mechanisms for VEGFC and VEGFD.	CCBE1 PROX1	5.86e-05	9	45	2	27159393
Pubmed	Microglia ablation alleviates myelin-associated catatonic signs in mice.	CADPS CNP	5.86e-05	9	45	2	29252214
Pubmed	FEM1 proteins are ancient regulators of SLBP degradation.	CCNF CUL2	7.32e-05	10	45	2	28118078
Pubmed	CCBE1 Is Essential for Epicardial Function during Myocardium Development.	CCBE1 PROX1	7.32e-05	10	45	2	36293499
Pubmed	Regulation of cullin RING E3 ubiquitin ligases by CAND1 in vivo.	CUL5 CUL2	7.32e-05	10	45	2	21249194
Pubmed	CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.	CUL5 CUL2 LARP1 CYFIP1	9.14e-05	182	45	4	31067453
Pubmed	The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes.	CUL5 CUL2	1.07e-04	12	45	2	19617556
Pubmed	Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes.	CUL5 CUL2	1.07e-04	12	45	2	21119685
Pubmed	Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase.	CUL5 CUL2	1.07e-04	12	45	2	11384984
Pubmed	SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation.	CUL5 CUL2	1.07e-04	12	45	2	18826954
Pubmed	KEAP1 Mutations Drive Tumorigenesis by Suppressing SOX9 Ubiquitination and Degradation.	CUL5 CUL2	1.07e-04	12	45	2	33173725
Pubmed	Distinct nuclear localization patterns of DNA methyltransferases in developing and mature mammalian retina.	NRL PROX1	1.07e-04	12	45	2	21452232
Pubmed	Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1.	CUL5 CUL2	1.27e-04	13	45	2	19037258
Pubmed	Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes.	CUL5 CUL2	1.27e-04	13	45	2	23201271
Pubmed	The intraflagellar transport protein IFT27 promotes BBSome exit from cilia through the GTPase ARL6/BBS3.	IFT172 IFT81	1.27e-04	13	45	2	25443296
Pubmed	The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation.	CUL5 CUL2	1.27e-04	13	45	2	29958295
Pubmed	ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity.	CUL5 CUL2	1.47e-04	14	45	2	10230407
Pubmed	Pogz deficiency leads to transcription dysregulation and impaired cerebellar activity underlying autism-like behavior in mice.	CNP PROX1	1.47e-04	14	45	2	33203851
Pubmed	Stem cell-driven lymphatic remodeling coordinates tissue regeneration.	CCBE1 PROX1	1.47e-04	14	45	2	31672914
Pubmed	TTC26/DYF13 is an intraflagellar transport protein required for transport of motility-related proteins into flagella.	IFT172 IFT81	1.47e-04	14	45	2	24596149
Pubmed	TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes.	CUL5 CUL2	1.47e-04	14	45	2	24076655
Pubmed	Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC.	TLK2 LARP1	1.47e-04	14	45	2	22354037
Pubmed	Herpes virus deneddylases interrupt the cullin-RING ligase neddylation cycle by inhibiting the binding of CAND1.	CUL5 CUL2	1.47e-04	14	45	2	22474075
Pubmed	Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis.	CUL2 MSH6 IFT81 HDAC8	1.56e-04	209	45	4	26389662
Pubmed	CRISPR/Cas9-mediated Genomic Editing of Cluap1/IFT38 Reveals a New Role in Actin Arrangement.	IFT172 CNP DHRS7 IFT81	1.67e-04	213	45	4	29615496
Pubmed	A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy.	CCBE1 PROX1	1.70e-04	15	45	2	23299940
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	CUL2 LARP1 MSH6 CPT1A SRRM2 RBL2	1.90e-04	655	45	6	35819319
Pubmed	Impaired Reelin-Dab1 Signaling Contributes to Neuronal Migration Deficits of Tuberous Sclerosis Complex.	CUL5 TSC2	1.94e-04	16	45	2	26235615
Pubmed	A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes.	LARP1 TSC2 RAB11FIP2	1.99e-04	87	45	3	17979178
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	KDM3B TLK1 CADPS UNC80	2.06e-04	225	45	4	12168954
Pubmed	Differential requirements for Tousled-like kinases 1 and 2 in mammalian development.	TLK2 TLK1	2.20e-04	17	45	2	28708136
Pubmed	Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus.	DHRS7 PROX1	2.20e-04	17	45	2	33084572
Pubmed	Overall Architecture of the Intraflagellar Transport (IFT)-B Complex Containing Cluap1/IFT38 as an Essential Component of the IFT-B Peripheral Subcomplex.	IFT172 IFT81	2.20e-04	17	45	2	26980730
Pubmed	Prickle1 is expressed in distinct cell populations of the central nervous system and contributes to neuronal morphogenesis.	NRL CNP	2.20e-04	17	45	2	23420014
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	HEXA KDM3B CUL2 LARP1 CYFIP1 CPT1A SRRM2 CNP	2.31e-04	1297	45	8	33545068
Pubmed	RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly.	CUL5 IFT172 IFT81	2.35e-04	92	45	3	23055941
Pubmed	Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.	CUL5 CUL2	2.47e-04	18	45	2	26906416
Pubmed	The Spalt family transcription factor Sall3 regulates the development of cone photoreceptors and retinal horizontal interneurons.	NRL PROX1	2.47e-04	18	45	2	21558380
Pubmed	VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.	CUL5 CUL2	2.47e-04	18	45	2	15601820
Pubmed	Characterization of Cullin-box sequences that direct recruitment of Cul2-Rbx1 and Cul5-Rbx2 modules to Elongin BC-based ubiquitin ligases.	CUL5 CUL2	2.47e-04	18	45	2	18187417
Pubmed	The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7.	CUL5 CUL2	2.76e-04	19	45	2	22405651
Pubmed	Plexin-B2, but not Plexin-B1, critically modulates neuronal migration and patterning of the developing nervous system in vivo.	CNP PROX1	2.76e-04	19	45	2	17554007
Pubmed	Timing of mTOR activation affects tuberous sclerosis complex neuropathology in mouse models.	TSC2 CNP	2.76e-04	19	45	2	23744272
Pubmed	Characterization of mouse IFT complex B.	IFT172 IFT81	3.06e-04	20	45	2	19253336
Pubmed	CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling.	CUL2 CCDC22	3.06e-04	20	45	2	23563313
Pubmed	COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.	CUL5 CUL2	3.06e-04	20	45	2	21778237
Pubmed	The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis.	CCBE1 PROX1	3.06e-04	20	45	2	23426945
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	LARP1 TSC2 SRRM2 RAB11FIP2	3.32e-04	255	45	4	15324660
Pubmed	Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome.	CUL5 CUL2	3.38e-04	21	45	2	11337588
Pubmed	Vif hijacks CBF-β to degrade APOBEC3G and promote HIV-1 infection.	CUL5 CUL2	3.38e-04	21	45	2	22190037
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	LARP1 MSH6 EVPL TSC2 KAZN TTC21A	3.55e-04	736	45	6	29676528
Pubmed	Coupled monoubiquitylation of the co-E3 ligase DCNL1 by Ariadne-RBR E3 ubiquitin ligases promotes cullin-RING ligase complex remodeling.	CUL5 CUL2	3.72e-04	22	45	2	30587576
Pubmed	MATH5 controls the acquisition of multiple retinal cell fates.	NRL PROX1	3.72e-04	22	45	2	21087508
Pubmed	CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling.	CUL5 CUL2 CNP	3.76e-04	108	45	3	30166453
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	CUL5 KDM3B CUL2 RNF216 CPT1A	3.84e-04	481	45	5	28190767
Pubmed	E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification.	CUL5 CUL2	4.07e-04	23	45	2	19250909
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	LARP1 MSH6 TSC2 CYFIP1 CPT1A SRRM2 ZNHIT2 CNP	4.14e-04	1415	45	8	28515276
Pubmed	Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.	MKLN1 CUL2 MSH6 SRRM2	4.18e-04	271	45	4	25737280
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	MKLN1 MSH6 CYFIP1 CADPS CNP	4.41e-04	496	45	5	31343991
Pubmed	Lymphatic function is required prenatally for lung inflation at birth.	CCBE1 PROX1	4.44e-04	24	45	2	24733830
Pubmed	Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.	CPT1A SRRM2 RBL2 TMEM181 CNP	4.54e-04	499	45	5	22810586
Cytoband	16p13.3	CCNF TSC2 SRRM2	1.78e-03	244	45	3	16p13.3
GeneFamily	Intraflagellar transport proteins\|Tetratricopeptide repeat domain containing	IFT172 TTC21A IFT81	9.02e-06	24	31	3	615
GeneFamily	La ribonucleoprotein domain containing\|RNA binding motif containing	LARP1 LARP1B	5.94e-05	7	31	2	625
GeneFamily	Cullins	CUL5 CUL2	7.92e-05	8	31	2	1032
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	PLAGL2 ZNF695 ZNF155 RREB1 KLF5 ZNF445	1.21e-03	718	31	6	28
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	KIFBP TTC21A	1.65e-02	115	31	2	769
Coexpression	GSE411_100MIN_VS_400MIN_IL6_STIM_MACROPHAGE_UP	CYFIP1 CPT1A RREB1 TMEM181 DHRS7	2.35e-05	200	45	5	M5997
Coexpression	GSE29164_CD8_TCELL_VS_CD8_TCELL_AND_IL12_TREATED_MELANOMA_DAY7_UP	RNF216 CYFIP1 RREB1 RBL2 DHRS7	2.35e-05	200	45	5	M8500
Drug	ms37	TLK2 TLK1	3.82e-06	2	45	2	CID016122503
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	TLK2 SRRM2	2.91e-04	17	44	2	DOID:0060307 (is_implicated_in)
Disease	anxiety disorder (implicated_via_orthology)	KDM3B TSC2	4.93e-04	22	44	2	DOID:2030 (implicated_via_orthology)
Disease	Intellectual Disability	HEXA TLK2 KDM3B KIFBP CCBE1	5.21e-04	447	44	5	C3714756
Disease	fasting blood glucose measurement	MKLN1 RREB1 CADPS PROX1	8.76e-04	287	44	4	EFO_0004465
Disease	Mental Retardation, Psychosocial	HEXA KIFBP CCBE1	1.18e-03	139	44	3	C0025363
Disease	Profound Mental Retardation	HEXA KIFBP CCBE1	1.18e-03	139	44	3	C0020796
Disease	Mental deficiency	HEXA KIFBP CCBE1	1.18e-03	139	44	3	C0917816
Disease	hoarding disorder	TLK2 MSH6	1.33e-03	36	44	2	EFO_0803361
Disease	Thyroid carcinoma	MSH6 TSC2	1.98e-03	44	44	2	C0549473
Disease	body mass index, fasting blood glucose measurement	RREB1 PROX1	2.65e-03	51	44	2	EFO_0004340, EFO_0004465

Protein segments in the cluster

Peptide	Gene	Start	Entry
EEKRALRYLETRREC	CUL5	241	Q93034
IHAILLYRRKLDREE	CPT1A	276	P50416
EYRHLRKLQDCRELE	CCDC22	431	O60826
ARRVHELERVKRRCL	DHRS7	81	Q9Y394
RTRVEILHRLCDYRL	CECR2	111	Q9BXF3
RKVYHLAAVRLRDLC	RBL2	841	Q08999
RHLCYLRDLLERAEN	CADPS	726	Q9ULU8
RRLCHAERRKDFVSE	CYFIP1	141	Q7L576
RSYRKLEERVHLECD	DGKK	906	Q5KSL6
HKYRRRCLNERKRLG	LARP1	891	Q6PKG0
LHRRKLRLAIEDYRD	KAZN	496	Q674X7
AKIYERCELAARLER	SPACA5	21	Q96QH8
AALRCRRISKEEYHL	EVPL	1751	Q92817
ARLARERDLYKARCD	NRL	206	P54845
LHKCRECRLERYRKF	KDM3B	911	Q7LBC6
HISKYDRVVRREICR	MSH6	501	P52701
LFRDRKLRLHLYDIE	IFT172	501	Q9UG01
RRLREECLQEESRYH	IFT81	551	Q8WYA0
LHLTVECVDRYLRRR	CCNF	331	P41002
FRRKRRLHLVFEYCD	CDKL1	71	Q00532
RERHRKREKPYCLDI	CCBE1	121	Q6UXH8
GRLKDEEIRCRKYLH	CUL2	241	Q13617
KRLDEDLAAYCRRRD	CNP	101	P09543
RRKFERILYVDLDLH	HDAC8	166	Q9BY41
EHLVKCLRLLRRYRL	KIFBP	116	Q96EK5
VYHKYRRRCLSERKR	LARP1B	711	Q659C4
AYERLSHFRCELLRR	HEXA	496	P06865
DILDHERKRRVELRC	SRRM2	56	Q9UQ35
YREQEAIRLCLKHFR	MKLN1	171	Q9UL63
RLCDEHLRAKRARVE	PROX1	156	Q92786
LENKRRHCRSYDRRA	RNF216	456	Q9NWF9
CDRRFYTRKDVRRHL	PLAGL2	196	Q9UPG8
AFIRRCLAYRKEDRI	TLK2	716	Q86UE8
IRRCLAYRKEDRFDV	TLK1	711	Q9UKI8
LRRYERCCLEKLRLR	ZNF695	111	Q8IW36
SCRLRLDPELDRHRY	UNC80	1376	Q8N2C7
RLCGEDLKHYRALRI	RREB1	756	Q92766
ELKHLCRRLREAYRE	TMEM181	111	Q9P2C4
CRRLREAYRELKEDL	TMEM181	116	Q9P2C4
LLRRKDTHIRELEDY	RAB11FIP2	466	Q7L804
RRLYIRCYRELCEHL	TTC21A	711	Q8NDW8
AREERDHLYRARKKC	ZNHIT2	326	Q9UHR6
CEKAFRRLSAYRLHR	ZNF445	546	P59923
DCGRRYKRRLNLDIL	ZNF155	516	Q12901
HIKRLRQRICEEAAY	TSC2	1746	P49815
RRSNPDLEKRRIHYC	KLF5	361	Q13887