Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity	CBR4 FASN	6.38e-05	2	160	2	GO:0004316
GeneOntologyBiologicalProcess	cellular catabolic process	SLC25A46 ATG5 PNPLA2 ACACB RUBCNL UBR4 CYP27B1 SESN3 TAB2 MGLL DRAM2 ATG2A ABCA7 STAT3 FBXL4 ERAP2 TGFBRAP1 MYLIP LPIN2 ZFYVE26 DEPDC5 SESN2 ATM ABHD12	3.69e-05	1253	160	24	GO:0044248
GeneOntologyBiologicalProcess	negative regulation of TORC1 signaling	SZT2 SESN3 DEPDC5 SESN2 ATM	5.11e-05	52	160	5	GO:1904262
GeneOntologyBiologicalProcess	monocyte activation involved in immune response	DYSF FER1L5	5.98e-05	2	160	2	GO:0002280
GeneOntologyBiologicalProcess	telomerase catalytic core complex assembly	ATR ATM	5.98e-05	2	160	2	GO:1904868
GeneOntologyBiologicalProcess	positive regulation of telomerase catalytic core complex assembly	ATR ATM	5.98e-05	2	160	2	GO:1904884
GeneOntologyBiologicalProcess	regulation of telomerase catalytic core complex assembly	ATR ATM	5.98e-05	2	160	2	GO:1904882
GeneOntologyCellularComponent	Seh1-associated complex	SZT2 SESN3 DEPDC5 SESN2	5.74e-06	16	161	4	GO:0035859
GeneOntologyCellularComponent	cullin-RING ubiquitin ligase complex	DET1 ZSWIM5 ANKRD9 FBXL5 FBXL4 PRAMEF14 DEPDC5 DCAF4 DCAF7	4.04e-05	212	161	9	GO:0031461
GeneOntologyCellularComponent	ubiquitin ligase complex	DET1 ZSWIM5 ANKRD9 FBXL5 FBXL4 PRAMEF14 ABTB1 UBR3 DEPDC5 DCAF4 DCAF7	9.29e-05	352	161	11	GO:0000151
GeneOntologyCellularComponent	GATOR2 complex	SZT2 SESN3 SESN2	9.37e-05	12	161	3	GO:0061700
GeneOntologyCellularComponent	phagophore	ATG5 ATG2A	1.76e-04	3	161	2	GO:0061908
GeneOntologyCellularComponent	t-UTP complex	NOL11 HEATR1	1.76e-04	3	161	2	GO:0034455
GeneOntologyCellularComponent	GATOR1 complex	SZT2 DEPDC5	5.81e-04	5	161	2	GO:1990130
Domain	Ank	ANKRD9 TEX14 ANKRD44 TNNI3K ABTB1 ANKRD28 TRPV6 TNKS ANKRD52 ANKS3	2.64e-05	228	159	10	PF00023
Domain	ANK	ANKRD9 TEX14 ANKRD44 TNNI3K ABTB1 ANKRD28 TRPV6 TNKS ANKRD52 ANKS3	5.94e-05	251	159	10	SM00248
Domain	ANK_REPEAT	ANKRD9 TEX14 ANKRD44 TNNI3K ABTB1 ANKRD28 TRPV6 TNKS ANKRD52 ANKS3	6.35e-05	253	159	10	PS50088
Domain	Ankyrin_rpt-contain_dom	ANKRD9 TEX14 ANKRD44 TNNI3K ABTB1 ANKRD28 TRPV6 TNKS ANKRD52 ANKS3	6.56e-05	254	159	10	IPR020683
Domain	ANK_REP_REGION	ANKRD9 TEX14 ANKRD44 TNNI3K ABTB1 ANKRD28 TRPV6 TNKS ANKRD52 ANKS3	6.56e-05	254	159	10	PS50297
Domain	Ankyrin_rpt	ANKRD9 TEX14 ANKRD44 TNNI3K ABTB1 ANKRD28 TRPV6 TNKS ANKRD52 ANKS3	8.49e-05	262	159	10	IPR002110
Domain	FerA	DYSF FER1L5	2.15e-04	3	159	2	SM01200
Domain	Ferlin_A-domain	DYSF FER1L5	2.15e-04	3	159	2	IPR012560
Domain	FerA	DYSF FER1L5	2.15e-04	3	159	2	PF08165
Domain	Sestrin	SESN3 SESN2	2.15e-04	3	159	2	IPR006730
Domain	AhpD-like	SESN3 SESN2	2.15e-04	3	159	2	IPR029032
Domain	PA26	SESN3 SESN2	2.15e-04	3	159	2	PF04636
Domain	-	SESN3 SESN2	2.15e-04	3	159	2	1.20.1290.10
Domain	-	ANKRD9 TEX14 ANKRD44 ABTB1 ANKRD28 TRPV6 TNKS ANKRD52 ANKS3	2.80e-04	248	159	9	1.25.40.20
Domain	DysFC	DYSF FER1L5	4.27e-04	4	159	2	SM00694
Domain	DysFN	DYSF FER1L5	4.27e-04	4	159	2	SM00693
Domain	Peroxin/Ferlin	DYSF FER1L5	4.27e-04	4	159	2	IPR006614
Domain	Ank_2	TEX14 ANKRD44 ABTB1 ANKRD28 TRPV6 TNKS ANKRD52 ANKS3	5.19e-04	215	159	8	PF12796
Domain	FerI	DYSF FER1L5	7.08e-04	5	159	2	SM01202
Domain	FerB	DYSF FER1L5	7.08e-04	5	159	2	SM01201
Domain	Ferlin_B-domain	DYSF FER1L5	7.08e-04	5	159	2	IPR012561
Domain	zf-RING_9	RUBCNL PLEKHM3	7.08e-04	5	159	2	PF13901
Domain	Ferlin_C	DYSF FER1L5	7.08e-04	5	159	2	PF16165
Domain	Ferlin_C	DYSF FER1L5	7.08e-04	5	159	2	IPR032362
Domain	FerIin_dom	DYSF FER1L5	7.08e-04	5	159	2	IPR012968
Domain	FerI	DYSF FER1L5	7.08e-04	5	159	2	PF08151
Domain	FerB	DYSF FER1L5	7.08e-04	5	159	2	PF08150
Domain	Zf-RING_9	RUBCNL PLEKHM3	7.08e-04	5	159	2	IPR025258
Domain	FATC	ATR ATM	7.08e-04	5	159	2	PF02260
Domain	DUF4206	RUBCNL PLEKHM3	7.08e-04	5	159	2	SM01175
Domain	RIH_assoc-dom	RYR3 ITPR2	1.06e-03	6	159	2	IPR013662
Domain	Dilute_dom	MYO5C RADIL	1.06e-03	6	159	2	IPR002710
Domain	2FE2S_FER_2	XDH FDX2	1.06e-03	6	159	2	PS51085
Domain	2Fe-2S_ferredoxin-type	XDH FDX2	1.06e-03	6	159	2	IPR001041
Domain	Ins145_P3_rec	RYR3 ITPR2	1.06e-03	6	159	2	PF08709
Domain	DIL	MYO5C RADIL	1.06e-03	6	159	2	PF01843
Domain	RIH_assoc	RYR3 ITPR2	1.06e-03	6	159	2	PF08454
Domain	RIH_dom	RYR3 ITPR2	1.06e-03	6	159	2	IPR000699
Domain	Ins145_P3_rcpt	RYR3 ITPR2	1.06e-03	6	159	2	IPR014821
Domain	Ryanodine_recept-rel	RYR3 ITPR2	1.06e-03	6	159	2	IPR015925
Domain	PKD/REJ-like	PKD1L1 KIAA0319L	1.06e-03	6	159	2	IPR002859
Domain	Fer2	XDH FDX2	1.06e-03	6	159	2	PF00111
Domain	FAT	ATR ATM	1.06e-03	6	159	2	PS51189
Domain	FATC	ATR ATM	1.06e-03	6	159	2	PS51190
Domain	-	RYR3 ITPR2	1.06e-03	6	159	2	1.25.10.30
Domain	REJ	PKD1L1 KIAA0319L	1.06e-03	6	159	2	PF02010
Domain	FAT	ATR ATM	1.06e-03	6	159	2	PF02259
Domain	DILUTE	MYO5C RADIL	1.06e-03	6	159	2	PS51126
Domain	PIK-rel_kinase_FAT	ATR ATM	1.06e-03	6	159	2	IPR003151
Domain	FATC_dom	ATR ATM	1.06e-03	6	159	2	IPR003152
Domain	RYDR_ITPR	RYR3 ITPR2	1.06e-03	6	159	2	PF01365
Domain	PIK_FAT	ATR ATM	1.06e-03	6	159	2	IPR014009
Domain	DIL	MYO5C RADIL	1.06e-03	6	159	2	SM01132
Domain	FATC	ATR ATM	1.06e-03	6	159	2	SM01343
Domain	STAT_TF_DNA-bd_sub	STAT2 STAT3	1.47e-03	7	159	2	IPR012345
Domain	STAT	STAT2 STAT3	1.47e-03	7	159	2	IPR001217
Domain	STAT_int	STAT2 STAT3	1.47e-03	7	159	2	SM00964
Domain	STAT_TF_DNA-bd	STAT2 STAT3	1.47e-03	7	159	2	IPR013801
Domain	STAT_bind	STAT2 STAT3	1.47e-03	7	159	2	PF02864
Domain	STAT_int	STAT2 STAT3	1.47e-03	7	159	2	PF02865
Domain	-	STAT2 STAT3	1.47e-03	7	159	2	1.10.532.10
Domain	STAT_alpha	STAT2 STAT3	1.47e-03	7	159	2	PF01017
Domain	ZnF_UBR1	UBR4 UBR3	1.47e-03	7	159	2	SM00396
Domain	-	STAT2 STAT3	1.47e-03	7	159	2	1.20.1050.20
Domain	STAT_TF_prot_interaction	STAT2 STAT3	1.47e-03	7	159	2	IPR013799
Domain	STAT_TF_coiled-coil	STAT2 STAT3	1.47e-03	7	159	2	IPR015988
Domain	-	STAT2 STAT3	1.47e-03	7	159	2	2.60.40.630
Domain	ZF_UBR	UBR4 UBR3	1.47e-03	7	159	2	PS51157
Domain	zf-UBR	UBR4 UBR3	1.47e-03	7	159	2	PF02207
Domain	Znf_UBR	UBR4 UBR3	1.47e-03	7	159	2	IPR003126
Domain	STAT_TF_alpha	STAT2 STAT3	1.95e-03	8	159	2	IPR013800
Domain	LAMININ_IVA	HSPG2 LAMA2	1.95e-03	8	159	2	PS51115
Domain	Laminin_B	HSPG2 LAMA2	1.95e-03	8	159	2	PF00052
Domain	LamB	HSPG2 LAMA2	1.95e-03	8	159	2	SM00281
Domain	Laminin_IV	HSPG2 LAMA2	1.95e-03	8	159	2	IPR000034
Domain	EGF_LAM_2	HSPG2 LAMA2 CELSR1	2.08e-03	30	159	3	PS50027
Domain	EGF_LAM_1	HSPG2 LAMA2 CELSR1	2.08e-03	30	159	3	PS01248
Domain	Hydrolase_4	MGLL ABHD12	2.49e-03	9	159	2	IPR022742
Domain	Hydrolase_4	MGLL ABHD12	2.49e-03	9	159	2	PF12146
Domain	PKD/Chitinase_dom	PKD1L1 KIAA0319L	2.49e-03	9	159	2	IPR022409
Domain	PKD	PKD1L1 KIAA0319L	2.49e-03	9	159	2	SM00089
Domain	MIR	RYR3 ITPR2	3.10e-03	10	159	2	PF02815
Domain	MIR_motif	RYR3 ITPR2	3.10e-03	10	159	2	IPR016093
Domain	MIR	RYR3 ITPR2	3.10e-03	10	159	2	PS50919
Domain	MIR	RYR3 ITPR2	3.10e-03	10	159	2	SM00472
Domain	EGF_Lam	HSPG2 LAMA2 CELSR1	3.24e-03	35	159	3	SM00180
Domain	Laminin_EGF	HSPG2 LAMA2 CELSR1	3.24e-03	35	159	3	PF00053
Domain	Tyr_Pase_AS	MTMR1 PTPRC PTPRZ1 SSH2	3.49e-03	73	159	4	IPR016130
Domain	MACPF	MPEG1 ASTN2	3.77e-03	11	159	2	PF01823
Domain	PKD	PKD1L1 KIAA0319L	3.77e-03	11	159	2	PS50093
Domain	PKD_dom	PKD1L1 KIAA0319L	3.77e-03	11	159	2	IPR000601
Domain	Laminin_G_1	HSPG2 LAMA2	3.77e-03	11	159	2	PF00054
Domain	-	PKD1L1 KIAA0319L	3.77e-03	11	159	2	2.60.40.670
Domain	LAM_G_DOMAIN	HSPG2 LAMA2 CELSR1	4.11e-03	38	159	3	PS50025
Domain	Laminin_EGF	HSPG2 LAMA2 CELSR1	4.11e-03	38	159	3	IPR002049
Domain	MACPF	MPEG1 ASTN2	4.49e-03	12	159	2	IPR020864
Domain	MACPF	MPEG1 ASTN2	4.49e-03	12	159	2	SM00457
Domain	Laminin_G_2	HSPG2 LAMA2 CELSR1	4.75e-03	40	159	3	PF02210
Domain	FN3	KIAA0319L DSCAML1 PTPRC PTPRZ1 ASTN2 CNTN2	5.10e-03	185	159	6	SM00060
Domain	-	XDH FDX2	6.13e-03	14	159	2	3.10.20.30
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HSPG2 PNPLA2 SZT2 ANKRD9 UBR4 KIAA0319L MUS81 ATG2A DYSF ZZEF1 ABCA7 ITPR2 RADIL FASN CELSR1 GAREM2 ZBED4 ZFYVE26 DEPDC5 KIFC3	2.70e-07	1105	163	20	35748872
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	SCO2 SLC4A7 DET1 SZT2 UBR4 MCM6 HEATR1 FBXL5 FBXL4 LMAN1L NBAS FASN PRDM10 ZBED4 FDFT1 MYLIP TAS1R1 CDK5RAP1 DEPDC5 SESN2 SSH2 HNRNPR	2.90e-07	1327	163	22	32694731
Pubmed	DNA damage repair machinery and HIV escape from innate immune sensing.	ATR MUS81 ATM	5.56e-06	8	163	3	24795708
Pubmed	Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains.	ANKRD44 ANKRD28 ANKRD52	5.56e-06	8	163	3	18186651
Pubmed	Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2.	ANKRD44 ANKRD28 ANKRD52	8.32e-06	9	163	3	21187329
Pubmed	Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins.	HSPG2 LAMA2 ITGA8 FREM1	1.01e-05	29	163	4	22613833
Pubmed	Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway.	ATR PTPRC ATM	1.62e-05	11	163	3	11551930
Pubmed	Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population.	ATR MUS81 PBOV1 ATM	1.71e-05	33	163	4	19714462
Pubmed	Rab40c regulates focal adhesions and PP6 activity by controlling ANKRD28 ubiquitylation.	ANKRD44 ANKRD28 ANKRD52	2.16e-05	12	163	3	35512830
Pubmed	The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1.	SESN3 DEPDC5 SESN2	2.16e-05	12	163	3	25263562
Pubmed	Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks.	ATR ATM	2.18e-05	2	163	2	19285939
Pubmed	Expression variations of DNA damage response genes ATM and ATR in blood cancer patients.	ATR ATM	2.18e-05	2	163	2	37338595
Pubmed	DNA damage induces a kinetochore-based ATM/ATR-independent SAC arrest unique to the first meiotic division in mouse oocytes.	ATR ATM	2.18e-05	2	163	2	28851706
Pubmed	Stat3 enhances vimentin gene expression by binding to the antisilencer element and interacting with the repressor protein, ZBP-89.	ZNF148 STAT3	2.18e-05	2	163	2	14712222
Pubmed	Novel insights into the mechanism of cell cycle kinases Mec1(ATR) and Tel1(ATM).	ATR ATM	2.18e-05	2	163	2	34151669
Pubmed	Dual orexin receptor antagonist (DORA-12) treatment affects the overall levels of Net/maoA mRNA expression in the hippocampus.	MAOA SLC6A2	2.18e-05	2	163	2	33451754
Pubmed	STAT3 regulates cytotoxicity of human CD57+ CD4+ T cells in blood and lymphoid follicles.	STAT3 B3GAT1	2.18e-05	2	163	2	29476109
Pubmed	Inhibition of Atm and/or Atr disrupts gene silencing on the inactive X chromosome.	ATR ATM	2.18e-05	2	163	2	16213462
Pubmed	ATR- and ATM-Mediated DNA Damage Response Is Dependent on Excision Repair Assembly during G1 but Not in S Phase of Cell Cycle.	ATR ATM	2.18e-05	2	163	2	27442013
Pubmed	Induction of ATM/ATR pathway combined with Vγ2Vδ2 T cells enhances cytotoxicity of ovarian cancer cells.	ATR ATM	2.18e-05	2	163	2	24726882
Pubmed	rRNA synthesis inhibitor, CX-5461, activates ATM/ATR pathway in acute lymphoblastic leukemia, arrests cells in G2 phase and induces apoptosis.	ATR ATM	2.18e-05	2	163	2	26061708
Pubmed	Role of integrin alpha8 in murine model of lung fibrosis.	ITGA8 ITGB8	2.18e-05	2	163	2	29813125
Pubmed	Functional significance for a heterogenous ribonucleoprotein A18 signature RNA motif in the 3'-untranslated region of ataxia telangiectasia mutated and Rad3-related (ATR) transcript.	ATR ATM	2.18e-05	2	163	2	20103595
Pubmed	Interplay between ATM and ATR in the regulation of common fragile site stability.	ATR ATM	2.18e-05	2	163	2	17934520
Pubmed	Depletion of ATR selectively sensitizes ATM-deficient human mammary epithelial cells to ionizing radiation and DNA-damaging agents.	ATR ATM	2.18e-05	2	163	2	25483091
Pubmed	ATM and ATR activities maintain replication fork integrity during SV40 chromatin replication.	ATR ATM	2.18e-05	2	163	2	23592994
Pubmed	Bleomycin-induced over-replication involves sustained inhibition of mitotic entry through the ATM/ATR pathway.	ATR ATM	2.18e-05	2	163	2	19527713
Pubmed	ATM and ATR signaling at a glance.	ATR ATM	2.18e-05	2	163	2	26567218
Pubmed	SPARC expression induces cell cycle arrest via STAT3 signaling pathway in medulloblastoma cells.	SPARC STAT3	2.18e-05	2	163	2	22206672
Pubmed	Cancer genome datamining and functional genetic analysis implicate mechanisms of ATM/ATR dysfunction underpinning carcinogenesis.	ATR ATM	2.18e-05	2	163	2	33742106
Pubmed	Roles of ATM and ATR in DNA double strand breaks and replication stress.	ATR ATM	2.18e-05	2	163	2	33887296
Pubmed	ATR disruption leads to chromosomal fragmentation and early embryonic lethality.	ATR ATM	2.18e-05	2	163	2	10691732
Pubmed	An interaction between the norepinephrine transporter and monoamine oxidase A polymorphisms, and novelty-seeking personality traits in Korean females.	MAOA SLC6A2	2.18e-05	2	163	2	17920180
Pubmed	[Fatty acid synthase interacts with signal transducer and activator of transcription 3 to promote migration and invasion in liver cancer cells].	STAT3 FASN	2.18e-05	2	163	2	31594092
Pubmed	Hypoosmotic stress induces R loop formation in nucleoli and ATR/ATM-dependent silencing of nucleolar transcription.	ATR ATM	2.18e-05	2	163	2	31114877
Pubmed	Shift in G1-Checkpoint from ATM-Alone to a Cooperative ATM Plus ATR Regulation with Increasing Dose of Radiation.	ATR ATM	2.18e-05	2	163	2	35011623
Pubmed	Dengue virus co-opts UBR4 to degrade STAT2 and antagonize type I interferon signaling.	UBR4 STAT2	2.18e-05	2	163	2	23555265
Pubmed	The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo.	ATR ATM	2.18e-05	2	163	2	26517239
Pubmed	DNA damage-sensing kinases mediate the mouse 2-cell embryo's response to genotoxic stress.	ATR ATM	2.18e-05	2	163	2	21593482
Pubmed	A synthetic lethal screen reveals enhanced sensitivity to ATR inhibitor treatment in mantle cell lymphoma with ATM loss-of-function.	ATR ATM	2.18e-05	2	163	2	25232030
Pubmed	ATM acts downstream of ATR in the DNA damage response signaling of bystander cells.	ATR ATM	2.18e-05	2	163	2	18757420
Pubmed	Cellular responses to the DNA strand-scission enediyne C-1027 can be independent of ATM, ATR, and DNA-PK kinases.	ATR ATM	2.18e-05	2	163	2	11927575
Pubmed	In Vivo and In Vitro Effects of ATM/ATR Signaling Pathway on Proliferation, Apoptosis, and Radiosensitivity of Nasopharyngeal Carcinoma Cells.	ATR ATM	2.18e-05	2	163	2	28820634
Pubmed	ATM and ATR play complementary roles in the behavior of excitatory and inhibitory vesicle populations.	ATR ATM	2.18e-05	2	163	2	29279380
Pubmed	ATR regulates fragile site stability.	ATR ATM	2.18e-05	2	163	2	12526805
Pubmed	Investigation of switch from ATM to ATR signaling at the sites of DNA damage induced by low and high LET radiation.	ATR ATM	2.18e-05	2	163	2	24238855
Pubmed	Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex.	ATR ATM	2.18e-05	2	163	2	16474843
Pubmed	The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.	ATR ATM	2.18e-05	2	163	2	8843195
Pubmed	Viral DNA replication-dependent DNA damage response activation during BK polyomavirus infection.	ATR ATM	2.18e-05	2	163	2	25694603
Pubmed	Ataxia-Telangiectasia and RAD3-Related and Ataxia-Telangiectasia-Mutated Proteins in Epithelial Ovarian Carcinoma: Their Expression and Clinical Significance.	ATR ATM	2.18e-05	2	163	2	26124337
Pubmed	Resveratrol analogue (E)-8-acetoxy-2-[2-(3,4-diacetoxyphenyl)ethenyl]-quinazoline induces G₂/M cell cycle arrest through the activation of ATM/ATR in human cervical carcinoma HeLa cells.	ATR ATM	2.18e-05	2	163	2	25812484
Pubmed	Roles of ATM and ATR-mediated DNA damage responses during lytic BK polyomavirus infection.	ATR ATM	2.18e-05	2	163	2	22952448
Pubmed	ATM regulates ATR chromatin loading in response to DNA double-strand breaks.	ATR ATM	2.18e-05	2	163	2	16461339
Pubmed	ATR localizes to the photoreceptor connecting cilium and deficiency leads to severe photoreceptor degeneration in mice.	ATR ATM	2.18e-05	2	163	2	23297361
Pubmed	Inactivation of ATM/ATR DNA damage checkpoint promotes androgen induced chromosomal instability in prostate epithelial cells.	ATR ATM	2.18e-05	2	163	2	23272087
Pubmed	The Dimeric Architecture of Checkpoint Kinases Mec1ATR and Tel1ATM Reveal a Common Structural Organization.	ATR ATM	2.18e-05	2	163	2	27129217
Pubmed	Dynamic dependence on ATR and ATM for double-strand break repair in human embryonic stem cells and neural descendants.	ATR ATM	2.18e-05	2	163	2	20368801
Pubmed	Clinicopathological significance of ataxia telangiectasia-mutated (ATM) kinase and ataxia telangiectasia-mutated and Rad3-related (ATR) kinase in MYC overexpressed breast cancers.	ATR ATM	2.18e-05	2	163	2	30746633
Pubmed	Proficiency in homologous recombination repair is prerequisite for activation of G2-checkpoint at low radiation doses.	ATR ATM	2.18e-05	2	163	2	33640756
Pubmed	A role for ATR in the DNA damage-induced phosphorylation of p53.	ATR ATM	2.18e-05	2	163	2	9925639
Pubmed	Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis.	IREB2 FBXL5	2.18e-05	2	163	2	30877170
Pubmed	Analysis of mutations that dissociate G(2) and essential S phase functions of human ataxia telangiectasia-mutated and Rad3-related (ATR) protein kinase.	ATR ATM	2.18e-05	2	163	2	21908846
Pubmed	The ATM and Rad3-Related (ATR) Protein Kinase Pathway Is Activated by Herpes Simplex Virus 1 and Required for Efficient Viral Replication.	ATR ATM	2.18e-05	2	163	2	29263259
Pubmed	Sestrins orchestrate cellular metabolism to attenuate aging.	SESN3 SESN2	2.18e-05	2	163	2	24055102
Pubmed	TEL/ETV6 is a signal transducer and activator of transcription 3 (Stat3)-induced repressor of Stat3 activity.	ETV6 STAT3	2.18e-05	2	163	2	15229229
Pubmed	An S/T-Q cluster domain census unveils new putative targets under Tel1/Mec1 control.	ATR ATM	2.18e-05	2	163	2	23176708
Pubmed	The ATM- and ATR-related SCD domain is over-represented in proteins involved in nervous system development.	ATR ATM	2.18e-05	2	163	2	26743489
Pubmed	Ataxia telangiectasia mutated (ATM) and ATM and Rad3-related protein exhibit selective target specificities in response to different forms of DNA damage.	ATR ATM	2.18e-05	2	163	2	15533933
Pubmed	ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling.	ATR ATM	2.18e-05	2	163	2	17124492
Pubmed	ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation.	ATR ATM	2.18e-05	2	163	2	12519769
Pubmed	Research progress on FASN and MGLL in the regulation of abnormal lipid metabolism and the relationship between tumor invasion and metastasis.	MGLL FASN	2.18e-05	2	163	2	33973101
Pubmed	The association of ATR protein with mouse meiotic chromosome cores.	ATR ATM	2.18e-05	2	163	2	10382071
Pubmed	Parallel SCF adaptor capture proteomics reveals a role for SCFFBXL17 in NRF2 activation via BACH1 repressor turnover.	MUS81 FBXL5 FBXL4 RABGGTB	2.44e-05	36	163	4	24035498
Pubmed	SZT2 dictates GATOR control of mTORC1 signalling.	SZT2 DEPDC5 SESN2	5.41e-05	16	163	3	28199315
Pubmed	Identification of a novel cell-adhesive protein spatiotemporally expressed in the basement membrane of mouse developing hair follicle.	HSPG2 ITGA8 FREM1	5.41e-05	16	163	3	15878328
Pubmed	Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.	STAT3 FASN FDFT1	5.41e-05	16	163	3	8833906
Pubmed	Perinatal lethality and endothelial cell abnormalities in several vessel compartments of fibulin-1-deficient mice.	HSPG2 LAMA2 ITGA8	5.41e-05	16	163	3	11564885
Pubmed	HIV-1 Vpr-a still "enigmatic multitasker".	ATR MUS81 ATM	5.41e-05	16	163	3	24744753
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	SLC4A7 CYP27B1 NOL11 MPEG1 TAB2 HEATR1 NEMP2 SLC6A2 PHKB AREL1 ZNF600 TRNT1 PTPRC FMN1 PRAMEF14 OTULINL	5.45e-05	1084	163	16	11544199
Pubmed	ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53- or ATM-defective chronic lymphocytic leukemia cells.	ATR ATM	6.53e-05	3	163	2	26563132
Pubmed	Sestrins inhibit mTORC1 kinase activation through the GATOR complex.	DEPDC5 SESN2	6.53e-05	3	163	2	25457612
Pubmed	Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12).	MGLL ABHD12	6.53e-05	3	163	2	22969151
Pubmed	Profiling cancer gene mutations in longitudinal epithelial ovarian cancer biopsies by targeted next-generation sequencing: a retrospective study.	ATR ATM	6.53e-05	3	163	2	25846551
Pubmed	SMCHD1 promotes ATM-dependent DNA damage signaling and repair of uncapped telomeres.	SMCHD1 ATM	6.53e-05	3	163	2	32080884
Pubmed	ATM- and ATR-mediated phosphorylation of XRCC3 regulates DNA double-strand break-induced checkpoint activation and repair.	ATR ATM	6.53e-05	3	163	2	23438602
Pubmed	Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation.	ATR ATM	6.53e-05	3	163	2	18344416
Pubmed	Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.	ATR ATM	6.53e-05	3	163	2	9766667
Pubmed	Sestrin1, 2, and 3 are dispensable for female fertility in mice.	SESN3 SESN2	6.53e-05	3	163	2	38297375
Pubmed	Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML.	ATR ATM	6.53e-05	3	163	2	27625305
Pubmed	Tagging single nucleotide polymorphisms in phosphoinositide-3-kinase-related protein kinase genes involved in DNA damage "checkpoints" and lung cancer susceptibility.	ATR ATM	6.53e-05	3	163	2	18451257
Pubmed	Association of MAOA, 5-HTT, and NET promoter polymorphisms with gene expression and protein activity in human placentas.	MAOA SLC6A2	6.53e-05	3	163	2	20332182
Pubmed	MAOA-mediated reprogramming of stromal fibroblasts promotes prostate tumorigenesis and cancer stemness.	MAOA STAT3	6.53e-05	3	163	2	32066880
Pubmed	A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein.	ATR ATM	6.53e-05	3	163	2	12773400
Pubmed	DNA Damage Signaling Is Required for Replication of Human Bocavirus 1 DNA in Dividing HEK293 Cells.	ATR ATM	6.53e-05	3	163	2	27733644
Pubmed	F-box and leucine-rich repeat protein 5 (FBXL5) is required for maintenance of cellular and systemic iron homeostasis.	IREB2 FBXL5	6.53e-05	3	163	2	23135277
Pubmed	Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.	ATR ATM	6.53e-05	3	163	2	11114888
Pubmed	Polymorphisms of COMT (c.649G>A), MAO-A (c.1460C>T), NET (c.1287G>A) Genes and the Level of Catecholamines, Serotonin in Patients with Parkinson's Disease.	MAOA SLC6A2	6.53e-05	3	163	2	28418735
Pubmed	The alkylating carcinogen N-methyl-N'-nitro-N-nitrosoguanidine activates the plasminogen activator inhibitor-1 gene through sequential phosphorylation of p53 by ATM and ATR kinases.	ATR ATM	6.53e-05	3	163	2	15735814
Pubmed	DNA-PKcs and ATM epistatically suppress DNA end resection and hyperactivation of ATR-dependent G2-checkpoint in S-phase irradiated cells.	ATR ATM	6.53e-05	3	163	2	31601897
Pubmed	ATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeres.	ATR ATM	6.53e-05	3	163	2	22842784
GeneFamily	Protein phosphatase 6 regulatory subunits	ANKRD44 ANKRD28 ANKRD52	3.98e-06	6	107	3	699
GeneFamily	Ankyrin repeat domain containing	ANKRD9 ANKRD44 ABTB1 ANKRD28 TRPV6 TNKS ANKRD52 ANKS3	9.57e-05	242	107	8	403
GeneFamily	Ferlin family	DYSF FER1L5	5.12e-04	6	107	2	828
GeneFamily	Ubiquitin protein ligase E3 component n-recognins	UBR4 UBR3	7.15e-04	7	107	2	785
GeneFamily	Fibronectin type III domain containing	DSCAML1 PTPRC PTPRZ1 ASTN2 CNTN2	2.62e-03	160	107	5	555
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RUBCNL ETV6 DYSF ANKRD44 SLC41A2 PTPRC PTPRZ1 PLEKHM3 OTULINL	1.12e-08	166	163	9	63dc58864268b4e7779e4c45155022556fc634f9
ToppCell	PCW_10-12-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_macrophage_(16)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	RUBCNL GPR84 MPEG1 MGLL SLC41A2 PTPRC MCTP1 FMN1 OASL	1.86e-08	176	163	9	98176bf3c961d5262593e2d5d002836adb010e13
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC4A7 CALCR MGLL RYR3 FBXL4 RAPGEF3 FMN1 ASTN2 LNX1	3.45e-08	189	163	9	e059be2965cca70ff5576df055d0af1775b76e00
ToppCell	droplet-Heart-nan-18m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PNPLA2 XDH MGLL DYSF RAPGEF3 TMEM44 MYLIP LNX1	4.41e-07	186	163	8	49ad01d216860a2bd4d63905a7064471b02f2b37
ToppCell	droplet-Heart-nan-18m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PNPLA2 XDH MGLL DYSF RAPGEF3 TMEM44 MYLIP LNX1	4.78e-07	188	163	8	9dfa2e0b73640459cdf88277291e3ab9c33e0217
ToppCell	PCW_10-12-Hematologic_Myeloid-Hem_Myeloid_macrophage\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	RUBCNL GPR84 MPEG1 MGLL SLC41A2 PTPRC MCTP1 FMN1	4.98e-07	189	163	8	440c422369de1c49112d18cf8c506a2a3a81f6ba
ToppCell	PCW_10-12-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_immature_macrophage2_(0)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	RUBCNL GPR84 MPEG1 MGLL SLC41A2 PTPRC MCTP1 FMN1	5.18e-07	190	163	8	e0b363f772817cfc6ab425430805c1cddcba23f0
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SLC4A7 SMCHD1 SESN3 GPR52 ITGB8 ANKRD44 PABPC1L ATM	5.84e-07	193	163	8	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RUBCNL MPEG1 ANKRD44 VENTX PTPRC MCTP1 FMN1 OTULINL	6.81e-07	197	163	8	d95565652ca318a2298d6918d54ba6367e9560f4
ToppCell	droplet-Pancreas-Exocrine-18m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 SPARC XDH MGLL DYSF RAPGEF3 TMEM44	3.96e-06	176	163	7	eb63eb2c301e785196ccadac74a2940b2c524c62
ToppCell	Children_(3_yrs)\|World / Lineage, Cell type, age group and donor	ACACB TEX14 ANKRD44 PTPRC FMN1 OASL SSH2	4.27e-06	178	163	7	df2ecd3214590b914f2762db57efe780ba038db3
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ETV6 MON1A ATG2A STAT3 PTPRC MCTP1 SSH2	4.94e-06	182	163	7	dc32f8f6a3b13918eb8e93c018f5823d86344080
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CALCR MGLL MYO5C FMN1 KCNJ16 ASTN2 LNX1	5.31e-06	184	163	7	d33de57876817050b294f2ecb0a4eb0634cfa7f0
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-4\|TCGA-Pancreas / Sample_Type by Project: Shred V9	DOCK11 LAMA2 LRRTM3 FREM1 STAT3 ITPR2 DSTYK	5.31e-06	184	163	7	67164bb6bcae7322cb89b585c7aa10bce35b0ecd
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC4A7 ACACB FMN1 KCNJ16 ASTN2 KIFC3 LNX1	5.50e-06	185	163	7	03f64a7132b13a01ba47187e0e15c13ac88f7cb2
ToppCell	COVID-19-lung-B_cells\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DOCK11 SMCHD1 RUBCNL SESN3 ANKRD44 PTPRC ATM	5.50e-06	185	163	7	e8f1ad580f19705b5ca1d7d8867b2125f4891684
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	SMCHD1 HEATR1 ITPR2 ANKRD44 NBAS PTPRC ZNF587	5.70e-06	186	163	7	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC4A7 ACACB FMN1 KCNJ16 ASTN2 KIFC3 LNX1	5.70e-06	186	163	7	1850583d23903d08226aeb0edb3e07b0994330e4
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC4A7 ACACB FMN1 KCNJ16 ASTN2 KIFC3 LNX1	5.70e-06	186	163	7	4dafc215c42e7949f932a3627359c107943b5d6b
ToppCell	droplet-Limb_Muscle-nan-3m-Endothelial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZZEF1 TRNT1 MCTP1 RAPGEF3 TMEM44 OASL DCAF4	6.33e-06	189	163	7	16a4c92dd7a0d60f3691bd3130a091a9a54730f1
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-lymphocytic-T_lymphocytic-regulatory_T_cell\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SESN3 TAB2 STAT3 MYO5C CASK PTPRC OTULINL	6.55e-06	190	163	7	b69709323a9f1b368b5a4f87295b9f7fd9c9be8e
ToppCell	PCW_10-12-Hematologic_Myeloid-Hem_Myeloid_macrophage-im_immature_macrophage1_(2)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	RUBCNL GPR84 MPEG1 SLC41A2 PTPRC MCTP1 FMN1	6.78e-06	191	163	7	c383ae386bc53e73a683a9543c7dfed2a65257c5
ToppCell	facs-Brain_Myeloid\|facs / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPARC MPEG1 PTPRC MYLIP SSH2 OTULINL ABHD12	6.78e-06	191	163	7	bf1135b382a3bf8cddc19538bc38361ef1fc2de1
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic-Non-classical_Monocyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ETV6 FBXL5 ANKRD44 PTPRC MCTP1 FMN1 SSH2	6.78e-06	191	163	7	47a2afc4102199b4bc76bd01b2967c8016186462
ToppCell	COVID-19-kidney-Mito-rich_Distal\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CALCR DSCAML1 RAPGEF3 KCNJ16 ASTN2 LNX1 CDH16	6.78e-06	191	163	7	0965f621ebcd92ccdeb21cc27022180ce3cfe910
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RUBCNL MPEG1 VENTX PTPRC MCTP1 FMN1 OTULINL	7.51e-06	194	163	7	1dce6d4b6ac41f80677e3e4c335a4f383bd76f85
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK11 RUBCNL ETV6 SLC41A2 MCTP1 FMN1 ABHD12	7.76e-06	195	163	7	247803cf58c6d9c561a52aa34e581188ddad197e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RUBCNL MPEG1 VENTX PTPRC MCTP1 FMN1 OTULINL	7.76e-06	195	163	7	42bfdff88da1d07828c0ad65d412fb1752f0cee4
ToppCell	PCW_10-12-Hematologic_Myeloid\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	RUBCNL GPR84 MPEG1 SLC41A2 PTPRC MCTP1 FMN1	7.76e-06	195	163	7	6352cd749091cfdbf5cce3c354fa57883cc513e8
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK11 RUBCNL MPEG1 VENTX PTPRC MCTP1 FMN1	8.03e-06	196	163	7	cbc727b55b6433a701b1a331028a49960fcee6ee
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SLC4A7 SMCHD1 SESN3 STAT3 ANKRD44 PTPRC ATM	8.30e-06	197	163	7	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK11 RUBCNL ETV6 ANKRD44 PTPRC MCTP1 FMN1	8.30e-06	197	163	7	c9b1f2ee7eb31a66af331c5aae29e1bbb5186f5a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK11 MPEG1 ANKRD44 VENTX PTPRC MCTP1 FMN1	8.30e-06	197	163	7	6ca6e17b7cc5f7ea8d4b6ca1ff670969bee65a45
ToppCell	Fetal_29-31_weeks-Immune\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DOCK11 RUBCNL MPEG1 ITPR2 ANKRD44 PTPRC MCTP1	8.57e-06	198	163	7	5dff131356b8c22743bd27b2b21f86ee6e4a0a0d
ToppCell	Control-Control-Lymphocyte-T/NK-CD4+_T_activated\|Control / Disease, condition lineage and cell class	RASGRF2 SMCHD1 TEX14 OASL LPIN2 PABPC1L CNTN2	8.57e-06	198	163	7	ee71543559836fd59adc0da877b2ca538cba60cb
ToppCell	Parenchymal-NucSeq-Endothelial-Endothelia_vascular-VE_systemic_arterial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	HSPG2 SLC4A7 RASGRF2 DYSF TBC1D1 TMEM44 SHCBP1L	8.57e-06	198	163	7	88b4662be9cc933a402c52673fa5e00fa979c0db
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RUBCNL MPEG1 ANKRD44 VENTX PTPRC MCTP1 OTULINL	8.86e-06	199	163	7	04adf46975aa4194ea40c7480f8a517def5d929c
ToppCell	Hematolymphoid-Microglia-TYROBP--\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SLC4A7 DOCK11 RUBCNL ITPR2 CASK ANKRD44 PTPRC	9.15e-06	200	163	7	dc344b3ec51d506952e38f0b3a7795d65f9dd4eb
ToppCell	tumor_Lung-Endothelial_cells-Tumor_ECs\|Endothelial_cells / Location, Cell class and cell subclass	HSPG2 SPARC SESN3 MGLL MCTP1 ANKRD28 KIFC3	9.15e-06	200	163	7	9c1b30fa96565515a7160f439cadcd51482c41e9
ToppCell	Hematolymphoid-Microglia\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SLC4A7 DOCK11 RUBCNL ITPR2 CASK ANKRD44 PTPRC	9.15e-06	200	163	7	21bcca3b670fe9bac034aef2275d3de4a9a73e2b
ToppCell	Hematolymphoid-Microglia-TYROBP\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SLC4A7 DOCK11 RUBCNL ITPR2 CASK ANKRD44 PTPRC	9.15e-06	200	163	7	33036d21c1c82109284473a515c4f890b33fdd5c
ToppCell	Hematolymphoid-Microglia-TYROBP----L1-3\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SLC4A7 DOCK11 RUBCNL ITPR2 CASK ANKRD44 PTPRC	9.15e-06	200	163	7	a20dce14f94777687aad57d6fbe3258ad376f63f
ToppCell	Hematolymphoid-Microglia-TYROBP-\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SLC4A7 DOCK11 RUBCNL ITPR2 CASK ANKRD44 PTPRC	9.15e-06	200	163	7	3bba5219453322198e8fdb0921d5f8c403598751
ToppCell	Hematolymphoid-Microglia-TYROBP---\|Hematolymphoid / cells hierarchy compared to all cells using T-Statistic	SLC4A7 DOCK11 RUBCNL ITPR2 CASK ANKRD44 PTPRC	9.15e-06	200	163	7	a8646d0fca99f10827c2d2a12e584660ef7155f1
ToppCell	Healthy-CD4+_T_activated\|World / disease group, cell group and cell class	TEX14 ITGB8 OASL C1orf159 PABPC1L CNTN2	1.30e-05	140	163	6	407691970ec72a3afb45e431cf48814546b8acff
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B0\|367C / Donor, Lineage, Cell class and subclass (all cells)	ZFP14 DPP8 ZZEF1 ITPR2 ZNF600 CWF19L1	1.85e-05	149	163	6	41f28138bde45d0b814e116837e5a32b5e80d54a
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-Myeloid-cDC1\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GPR84 MPEG1 ETV6 PTPRC MCTP1 OASL	1.92e-05	150	163	6	3dc23a37dbeb7f9df93683702a7838f7cc3ec9cc
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c2-CXCR4(low)\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SMCHD1 FBXL5 ANKRD44 PTPRC PLEKHM3 SSH2	1.99e-05	151	163	6	b698ddc74565d47892c09c3f16d78038da2dd5e7
ToppCell	droplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-myeloid_leukocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A2 ANKRD44 PTPRC PLEKHM3 OTULINL CDH16	2.07e-05	152	163	6	7e686721b95c837f2b0d5116927c8ecacef055ee
ToppCell	metastatic_Brain-T/NK_cells-Cytotoxic_CD8+_T\|T/NK_cells / Location, Cell class and cell subclass	HHEX ITGA8 CELSR1 STS SESN2 UEVLD	2.86e-05	161	163	6	e6e294b4ba911c1327664f1a0f93207096c6de03
ToppCell	droplet-Fat-Mat-18m-Myeloid-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR84 MPEG1 PTPRC MCTP1 OTULINL ABHD12	2.86e-05	161	163	6	8c62ae3fcf304db0f71633e328ceba81a70f03c4
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	SMCHD1 SESN3 STAT3 ANKRD44 PTPRC ATM	2.96e-05	162	163	6	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	droplet-Lung-nan-18m-Myeloid-Intermediate_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPEG1 ETV6 TAB2 PTPRC SSH2 OTULINL	3.28e-05	165	163	6	0fbdd043e11aa8dbff4cd3a4da1b2feb49878a09
ToppCell	droplet-Lung-nan-18m-Myeloid-intermediate_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPEG1 ETV6 TAB2 PTPRC SSH2 OTULINL	3.28e-05	165	163	6	e32697321cef424c2ad4e11ee9da3e510d5ce505
ToppCell	Control-B_cells-Activated_B_cells\|Control / group, cell type (main and fine annotations)	SMCHD1 RUBCNL SESN3 ANKRD44 PTPRC ATM	3.63e-05	168	163	6	a7159a35fe37f8c241cf8d391debe271e0698105
ToppCell	COVID-19-Heart-Adipocyte\|Heart / Disease (COVID-19 only), tissue and cell type	PNPLA2 CALCR CYP27B1 RYR3 FASN ANKRD28	3.75e-05	169	163	6	bd39f85b48207955f80ca120a11e15a0124117b9
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary-EC_general_capillary_L.2.0.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HSPG2 SPARC RASGRF2 DYSF RAPGEF3 LNX1	3.75e-05	169	163	6	0d8b681404e18f3061d84425fb5f7d84e8e2b8d7
ToppCell	normal-na-Lymphocytic_B-B_plasma-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	HSPG2 FUT10 ITGA8 MGLL CELSR1 LNX1	3.87e-05	170	163	6	c5b87974dfddf9780051f7f5693eeeb0c606a3fe
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic-Neutrophil\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	SMCHD1 ETV6 MON1A ATG2A STAT3 PTPRC	4.00e-05	171	163	6	dcb15bc54aeea06ef8f07f1134f3ff1e21ac0e4f
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	SMCHD1 ETV6 MON1A ATG2A STAT3 PTPRC	4.00e-05	171	163	6	2b7c5a557c4bc5c573211c4d618bdd6766a24916
ToppCell	CF-Myeloid-Neutrophil\|Myeloid / Disease state, Lineage and Cell class	SMCHD1 RUBCNL ATG2A DYSF FBXL5 ABTB1	4.55e-05	175	163	6	8020c3a34f77e68e8149f87481fb1dddd2ac675e
ToppCell	Control-B_cells-B_cells\|Control / group, cell type (main and fine annotations)	RUBCNL SESN3 DRAM2 ANKRD44 PTPRC ATM	4.70e-05	176	163	6	d2c353783bd78dc24f28e00d917b88d8294fb5df
ToppCell	droplet-Liver-Hepatocytes-21m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MPEG1 AREL1 KCNJ16 PLEKHM3 ANKRD52 ABHD12	4.70e-05	176	163	6	8e89471f838ea81235256cc2470f1c12c9b75f8a
ToppCell	droplet-Liver-hepatocytes-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 SPARC RASGRF2 SLC41A2 DSTYK MYLIP	4.85e-05	177	163	6	8ef41ee5d63737b810ad7371b0437625e7e1badf
ToppCell	RV-11._Adipocyte\|World / Chamber and Cluster_Paper	PNPLA2 ACACB MAOA DOCK11 ITPR2 FASN	4.85e-05	177	163	6	f0edf04930692418953e4f00a917257804ec0ffd
ToppCell	T_cells-ISG-high_CD4+_T_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	SMCHD1 ETV6 STAT2 ERAP2 OASL LPIN2	5.16e-05	179	163	6	af35ef8a7768cee0c2af0590e5bec35cee6a4714
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TEX14 MYO5C SLC41A2 HHIP FMN1 LNX1	5.16e-05	179	163	6	fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HSPG2 HHEX RASGRF2 MGLL DYSF RAPGEF3	5.33e-05	180	163	6	755050226eeb1991ee7f0d15e39d0458f3e4a791
ToppCell	nucseq-Immune-Lymphocytic_B-Lymphocytic_B-B\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SMCHD1 RUBCNL SESN3 ANKRD44 ATM SSH2	5.49e-05	181	163	6	8d8cc4dae2c8bd5f4b1c159f2a52edc4c9449c86
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC4A7 ACACB ITPR2 FMN1 KCNJ16 LNX1	5.84e-05	183	163	6	31ab55d5f3639f5964541d5eae23044dbda3356e
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	SMCHD1 HEATR1 ANKRD44 NBAS PTPRC ZNF587	6.20e-05	185	163	6	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC4A7 ACACB ITPR2 FMN1 KCNJ16 LNX1	6.20e-05	185	163	6	898a093757f86be3e18d2ef1f16a71f50ef81dc3
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B0\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ZFP14 DPP8 ZZEF1 ITPR2 ZNF600 CWF19L1	6.39e-05	186	163	6	74c238759c5d3fd39127ec0060d0c2cb16b326d4
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RUBCNL MPEG1 ETV6 ANKRD44 PTPRC OTULINL	6.39e-05	186	163	6	305f1726b8b5add32f1c29c74991ff34f42e0da7
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HSPG2 DSCAML1 MYO5C CELSR1 LPIN2 KIFC3	6.39e-05	186	163	6	3aebe163799109ffc67e4e10ee47c2dd0886a92c
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC4A7 ACACB ITPR2 FMN1 KCNJ16 LNX1	6.58e-05	187	163	6	b93cf4dfe8ffb89348ee7bccc9f284189f7240a2
ToppCell	droplet-Pancreas-Exocrine-24m-Endothelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 SPARC XDH MGLL RAPGEF3 TMEM44	6.58e-05	187	163	6	a178b1fed80a0bf83aedb6262493ee17374734b5
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC4A7 CALCR ACACB MGLL FBXL4 LNX1	6.58e-05	187	163	6	7ea8731288e2a99f45e3958590ee1d76f49ae888
ToppCell	human_hepatoblastoma-Tumor_cells-T2\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ACACB RASGRF2 ZSWIM5 KIAA0319L DSCAML1 ITPR2	6.58e-05	187	163	6	f3e37c18ac6471c7992609bbddfa4975571c815c
ToppCell	normal_Lung-Myeloid_cells-pDCs\|normal_Lung / Location, Cell class and cell subclass	SLC4A7 MPEG1 HEATR1 DSCAML1 KIFC3 OTULINL	6.58e-05	187	163	6	d36751372fd40a46441f07735c9c3c5dcb503f24
ToppCell	droplet-Pancreas-Exocrine-24m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 SPARC XDH MGLL RAPGEF3 TMEM44	6.58e-05	187	163	6	e60cbccf5842f25123fd34b9475759b7424b32e9
ToppCell	Control-Endothelial-VE_Peribronchial\|Endothelial / Disease state, Lineage and Cell class	HSPG2 SPARC SLC4A7 RASGRF2 MCTP1 ANKRD28	6.58e-05	187	163	6	5429ae85942b8ec3895cceb63c663de3c24ca064
ToppCell	droplet-Pancreas-Exocrine-24m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 SPARC XDH MGLL RAPGEF3 TMEM44	6.58e-05	187	163	6	2b8eda2812be0be68a6f01aa4038925d3d5b1e65
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MYO5C SLC41A2 HHIP CELSR1 FMN1 LNX1	6.77e-05	188	163	6	4bdf8d49af0e9da349b16e3f012e1b0eec04cc4f
ToppCell	droplet-Fat-Scat-21m-Endothelial-Cd36+\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF2 MGLL DYSF RAPGEF3 MYLIP LNX1	6.77e-05	188	163	6	8671fdbc4138e6f9559920779c98628ed80f0da3
ToppCell	PCW_05-06-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor2_(3)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	HHEX GPR84 MPEG1 PTPRC MCTP1 FMN1	6.77e-05	188	163	6	f4d11d06be46f13adbf36d94bc2bdcd14d0bfa75
ToppCell	PCW_10-12-Hematologic_Myeloid-Hem_Myeloid_dendritic-im_migrating_dendritic_(5)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	RUBCNL GPR84 MPEG1 SLC41A2 PTPRC MCTP1	6.98e-05	189	163	6	35380ca9409206e82528bde4f3795057b015278a
ToppCell	COVID-19-Heart-Macrophage\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DOCK11 RUBCNL MPEG1 PTPRC MCTP1 FMN1	6.98e-05	189	163	6	2586f4088721c5debec86c2b211b739fd33713eb
ToppCell	droplet-Fat-Scat-21m-Endothelial-endothelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF2 MGLL DYSF RAPGEF3 MYLIP LNX1	7.18e-05	190	163	6	d3e46cf800a07ca9b01c78192962d223b9785d05
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC4A7 CALCR MGLL KCNJ16 ASTN2 LNX1	7.18e-05	190	163	6	bf4511395fa97efd1c1cd17cc9bebb0271ee7f0e
ToppCell	droplet-Fat-Scat-21m-Endothelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF2 MGLL DYSF RAPGEF3 MYLIP LNX1	7.18e-05	190	163	6	dd89ef1ecea20b2f6fbdc6cea4ca41b28b3ed822
ToppCell	facs-Pancreas-Exocrine-3m-Endothelial-endothelial_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 SPARC XDH MGLL DYSF RAPGEF3	7.18e-05	190	163	6	83cc851fb9f644b17a8ebf4d99a646003769a22f
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 NWD1 SPARC LRRTM3 TMEM44 MYLIP	7.18e-05	190	163	6	a08c5929b05a4969852e351a93c4e4deb4c8d5b6
ToppCell	facs-Pancreas-Exocrine-3m-Endothelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 SPARC XDH MGLL DYSF RAPGEF3	7.18e-05	190	163	6	b7fc451e160e31dc898b122de844b501f587db67
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC4A7 CALCR MGLL KCNJ16 ASTN2 LNX1	7.18e-05	190	163	6	b6b8964b4910083499681b5fdf554e127b6a4c4e
ToppCell	IPF-Lymphoid-T\|IPF / Disease state, Lineage and Cell class	SLC4A7 SMCHD1 CASK ANKRD44 PTPRC ZBED4	7.18e-05	190	163	6	d57df208aaf7a5554899bb9107c80b443fd0cf93
ToppCell	droplet-Liver-LIVER_NPC-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 NWD1 SPARC LRRTM3 TMEM44 MYLIP	7.18e-05	190	163	6	25525fee1da8a808034d9c916159fd0b6b26bce8
ToppCell	Control-T_cells-CD4+_T_cells\|Control / group, cell type (main and fine annotations)	SLC4A7 RASGRF2 SMCHD1 CASK ANKRD44 PTPRC	7.18e-05	190	163	6	0733be5e54fe15d6d6ea51c154a95258e83f1b92
ToppCell	Fetal_29-31_weeks-Immune-B_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SMCHD1 RUBCNL MTMR1 ANKRD44 PTPRC TBC1D1	7.18e-05	190	163	6	424550418c1bd4eb070cf3c41cf09fa9d89aef37
ToppCell	facs-Pancreas-Exocrine-3m-Endothelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSPG2 SPARC XDH MGLL DYSF RAPGEF3	7.18e-05	190	163	6	5f440d4b334d66d419c03bd828f7d93f16c1ce67
Disease	Malignant neoplasm of breast	HHEX MAOA RASGRF2 ZSWIM5 UBR4 LAMA2 XDH MAGEE1 DYSF STAT3 ZNF404 TYMS PHKB FASN PTPRC ASTN2 ZFYVE26 ATM HNRNPR	4.31e-06	1074	156	19	C0006142
Disease	ovarian neoplasm	ATG5 SPARC ATR ITGA8 STAT3 TYMS FASN	7.55e-06	134	156	7	C0919267
Disease	Malignant neoplasm of ovary	ATG5 SPARC ATR ITGA8 STAT3 TYMS FASN	8.73e-06	137	156	7	C1140680
Disease	ataxia telangiectasia (implicated_via_orthology)	ATR ATM	2.78e-05	2	156	2	DOID:12704 (implicated_via_orthology)
Disease	Inhalant adrenergic use measurement	SLC25A46 HHEX ITGB8 PTPRC OTULINL	1.61e-04	96	156	5	EFO_0009941
Disease	Congenital absence of kidneys syndrome	ITGA8 FREM1	2.75e-04	5	156	2	C1609433
Disease	Depressive Disorder, Treatment-Resistant	MAOA SLC6A2	2.75e-04	5	156	2	C2063866
Disease	muscular disease (implicated_via_orthology)	ACACB FASN	2.75e-04	5	156	2	DOID:0080000 (implicated_via_orthology)
Disease	axial length measurement, refractive error	RASGRF2 ASTN2	4.11e-04	6	156	2	EFO_0005318, MONDO_0004892
Disease	contactin-2 measurement	DSTYK CNTN2	4.11e-04	6	156	2	EFO_0008100
Disease	Thrombocytopenia	SPARC ETV6 XDH	4.79e-04	29	156	3	C0040034
Disease	hyperuricemia (implicated_via_orthology)	XDH STAT3	5.73e-04	7	156	2	DOID:1920 (implicated_via_orthology)
Disease	limb-girdle muscular dystrophy (implicated_via_orthology)	DYSF FER1L5	5.73e-04	7	156	2	DOID:11724 (implicated_via_orthology)
Disease	eosinophil percentage of leukocytes	ATG5 CYP27B1 ABCA7 ITGB8 CELSR1 TRNT1 PTPRC TBC1D1 SESN2 ATM OTULINL DCAF4	6.39e-04	746	156	12	EFO_0007991
Disease	psoriasis, type 2 diabetes mellitus	HHEX STAT2 ANKRD52 CWF19L1	6.83e-04	75	156	4	EFO_0000676, MONDO_0005148
Disease	Unilateral agenesis of kidney	FREM1 DSTYK	7.62e-04	8	156	2	C0266294
Disease	waist-hip ratio	CMKLR2 HHEX PNPLA2 CALCR SMCHD1 MGLL ZZEF1 ITGB8 HHIP RAPGEF3 DSTYK ABTB1 ANKRD28 ASTN2 CNTN2 HNRNPR	8.11e-04	1226	156	16	EFO_0004343
Disease	Adenocarcinoma of lung (disorder)	SLC4A7 ATR FKBP11 TYMS FASN ATM	8.21e-04	206	156	6	C0152013
Disease	respiratory system disease	SLC25A46 HHEX ITGB8 PTPRC OTULINL	1.06e-03	145	156	5	EFO_0000684
Disease	dentate gyrus volume measurement	PKD1L1 ASTN2 LNX1	1.15e-03	39	156	3	EFO_0010083
Disease	mean reticulocyte volume	SCO2 ATR ANKRD9 ETV6 DRAM2 DPP8 ABCA7 TYMS PTPRC FDFT1 LPIN2 ATM	1.15e-03	799	156	12	EFO_0010701
Disease	Optic Atrophy	SLC25A46 ABHD12	1.22e-03	10	156	2	C0029124
Disease	Anorectal Malformations	CASK TNNI3K HHIP	1.33e-03	41	156	3	C3495676
Disease	Situs Inversus	PKD1L1 ANKS3	1.48e-03	11	156	2	C0037221
Disease	quality of life during menstruation measurement, dysmenorrheic pain measurement	ETV6 MGLL	1.48e-03	11	156	2	EFO_0007889, EFO_0009366
Disease	nasopharynx carcinoma (is_marker_for)	ATR STAT3 ATM	1.53e-03	43	156	3	DOID:9261 (is_marker_for)
Disease	Prenatal Exposure Delayed Effects	MAOA ATM	1.77e-03	12	156	2	C0033054
Disease	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	ETV6 STAT3	1.77e-03	12	156	2	C0023485
Disease	upper aerodigestive tract neoplasm	HEATR1 SLC6A2 TBC1D1 TNKS LNX1 CWF19L1	2.03e-03	246	156	6	EFO_0004284
Disease	Hypercalcemia	CALCR CYP27B1	2.08e-03	13	156	2	C0020437
Disease	Milk-Alkali Syndrome	CALCR CYP27B1	2.08e-03	13	156	2	C0026141
Disease	ulcerative colitis	ATG5 HHEX UBR4 LRRTM3 STAT3 PTPRC ERAP2	2.10e-03	335	156	7	EFO_0000729
Disease	mean corpuscular hemoglobin concentration	SCO2 GPAA1 ATR ANKRD9 ETV6 IREB2 DPP8 ABCA7 STAT3 ITPR2 TYMS PTPRC ATP11B OR51V1	2.26e-03	1105	156	14	EFO_0004528
Disease	eosinophil count	ATG5 HHEX ATR CYP27B1 SESN3 MGLL DYSF ITGB8 CELSR1 PTPRC TBC1D1 SESN2 ATM GJB7 OTULINL FER1L5 DCAF4	2.33e-03	1488	156	17	EFO_0004842
Disease	Cardiomyopathy, Familial Idiopathic	PNPLA2 FASN ATM	2.37e-03	50	156	3	C1449563
Disease	Pneumoconiosis	ATR PTPRZ1	2.42e-03	14	156	2	C0032273
Disease	Bagassosis	ATR PTPRZ1	2.42e-03	14	156	2	C0004681
Disease	Autosomal recessive limb-girdle muscular dystrophy	TRAPPC11 DYSF	2.42e-03	14	156	2	cv:C2931907
Disease	inflammatory bowel disease	HHEX UBR4 TAB2 ITGB8 STAT3 PTPRC ERAP2 TBC1D1	2.77e-03	449	156	8	EFO_0003767
Disease	glycerate measurement	RYR3 MCTP1	2.79e-03	15	156	2	EFO_0021029
Disease	anemia (implicated_via_orthology)	SLC4A7 IREB2	2.79e-03	15	156	2	DOID:2355 (implicated_via_orthology)
Disease	Myopia	SCO2 LAMA2	2.79e-03	15	156	2	C0027092
Disease	5-oxoproline measurement	GPAA1 TMEM249	3.17e-03	16	156	2	EFO_0010988
Disease	myopia (is_implicated_in)	SCO2 LAMA2	3.17e-03	16	156	2	DOID:11830 (is_implicated_in)
Disease	colorectal mucinous adenocarcinoma	RASGRF2 ETV6	3.17e-03	16	156	2	EFO_0009361
Disease	Benign neoplasm of stomach	ATR ATM	3.59e-03	17	156	2	C0153943
Disease	Neoplasm of uncertain or unknown behavior of stomach	ATR ATM	3.59e-03	17	156	2	C0496905
Disease	muscular dystrophy (is_implicated_in)	LAMA2 DYSF	3.59e-03	17	156	2	DOID:9884 (is_implicated_in)
Disease	pre-malignant neoplasm (biomarker_via_orthology)	STAT3 ATM	3.59e-03	17	156	2	DOID:0060071 (biomarker_via_orthology)
Disease	renal fibrosis (implicated_via_orthology)	XDH GPR52	3.59e-03	17	156	2	DOID:0050855 (implicated_via_orthology)
Disease	Carcinoma in situ of stomach	ATR ATM	3.59e-03	17	156	2	C0154060
Disease	PROSTATE CANCER, HEREDITARY, 1	ITGB8 B3GAT1 ATM	3.98e-03	60	156	3	C4722327
Disease	atopic asthma	SLC25A46 ATG5 ITGB8 STAT3 OTULINL	4.21e-03	199	156	5	EFO_0010638
Disease	Congenital hernia of foramen of Morgagni	FREM1 STAT3	4.48e-03	19	156	2	C0265699
Disease	Congenital hernia of foramen of Bochdalek	FREM1 STAT3	4.48e-03	19	156	2	C0265700
Disease	sensorineural hearing loss (implicated_via_orthology)	OPN4 LNX1	4.48e-03	19	156	2	DOID:10003 (implicated_via_orthology)
Disease	Obesity	ACACB FASN STS RAPGEF3 TBC1D1	4.77e-03	205	156	5	C0028754
Disease	systolic blood pressure, alcohol drinking	SLC4A7 LMAN1L TNKS LNX1	4.83e-03	128	156	4	EFO_0004329, EFO_0006335
Disease	Stomach Neoplasms	ATR ITGA8 STAT3 TYMS NBAS ATM	5.10e-03	297	156	6	C0038356
Disease	Polyarthritis, Juvenile, Rheumatoid Factor Positive	ANKRD9 ETV6 DYSF STAT3	5.24e-03	131	156	4	C4704862
Disease	Polyarthritis, Juvenile, Rheumatoid Factor Negative	ANKRD9 ETV6 DYSF STAT3	5.24e-03	131	156	4	C4552091
Disease	Juvenile arthritis	ANKRD9 ETV6 DYSF STAT3	5.24e-03	131	156	4	C3495559
Disease	Juvenile psoriatic arthritis	ANKRD9 ETV6 DYSF STAT3	5.24e-03	131	156	4	C3714758

Protein segments in the cluster

Peptide	Gene	Start	Entry
VVHQSPTVLYLHSEL	nan	31	A4D1N5
DTGLNYTHLHVETPR	B3GAT1	136	Q9P2W7
AYLPLHVHEEEGILV	DCAF4	416	Q8WV16
TEGIPVLIVGHHILY	CHTF8	46	P0CG13
LSVETHLLYIIHGPV	CALCR	291	P30988
GTATYQLLVALHHPE	AQP10	256	Q96PS8
TPLHIAARYGHELLI	ANKRD28	341	O15084
GTLILQLHAHYTIEG	CELSR1	261	Q9NYQ6
TPLHVAARYGHELLI	ANKRD52	341	Q8NB46
EHLSYPDNFLHISII	ATG5	256	Q9H1Y0
SPLEDYSLHIIDLHT	DET1	186	Q7L5Y6
LRHLEHSTIIYEDPQ	DCAF7	206	P61962
PTHLELTCSDLHGIY	ATG2A	691	Q2TAZ0
TEATHEIHYIPSVLL	ASTN2	246	O75129
PHELVLVLPYTGAHD	ABCA7	1096	Q8IZY2
ELPYHLLHSGRLEEL	NWD1	731	Q149M9
ENHVLYPVASLSHLE	MTMR1	581	Q13613
QVPGHLTDELHLFSL	RUBCNL	551	Q9H714
GSYLALPALTNTHHE	HSPG2	3936	P98160
LYLDLHPDHSLTEQD	FMN1	676	Q68DA7
HVLLYLGDSVTTDHI	IREB2	741	P48200
GAHSVVLDLLQIPYE	ITPR2	1211	Q14571
YSPVHLLSQIHEEGY	MPEG1	416	Q2M385
ILHSAYSETFLLPHL	NOL11	591	Q9H8H0
TVVLHHGDLLSLGLY	RADIL	336	Q96JH8
EDALASSHPIILYLH	ABHD12	161	Q8N2K0
QILIASHLPSYELRH	ACACB	1226	O00763
LGSQEALHPVHYEEK	MAOA	381	P21397
YELSRHPEVQTALHS	CYP27B1	331	O15528
PTHSSAELLELAYHE	DEPDC5	651	O75140
SPHSGDVLYELLQHI	ETV6	106	P41212
DYSQLPGEDHILEHL	PNPLA2	286	Q96AD5
HPHIVELLETYSSDG	CASK	71	O14936
THYDHVLIELTQAGL	MCM6	781	Q14566
HYPDHDLGIILLSVI	MCTP1	366	Q6DN14
HVYGTELVVLDPRNH	MAGEE1	796	Q9HCI5
LYVLPVLGQHVATQH	GPAA1	441	O43292
GAYHVLHKELPEVTN	MGLL	266	Q99685
TVNDYTHALLRHDPL	HHEX	106	Q03014
HHPILFLSNLVEGTY	KIAA0319L	746	Q8IZA0
QVSYLPVGIEHHFLE	LMAN1L	411	Q9HAT1
ALHHIPDVITYLSRL	FDFT1	266	P37268
DHVLILPIGHYQSVV	CWF19L1	361	Q69YN2
TCHVYVSEDHLDLLP	FDX2	116	Q6P4F2
HLSPVAHVLIGNIYI	OR51V1	276	Q9H2C8
SHLSPEEISLHEEQY	NEMP2	386	A6NFY4
SYITAVTLHHIDPAL	DRAM2	26	Q6UX65
LQGYVTHLLDHTRPI	FREM1	341	Q5H8C1
HTEHYKTLIEAGLPQ	HNRNPR	26	O43390
TPLVHIIIQHIYRDG	LNX1	296	Q8TBB1
EHVQHVYLPTHTSLL	MYLIP	426	Q8WY64
VYLHPSEEHTNVLLL	LAMA2	641	P24043
TPLHVAARYGHELLI	ANKRD44	341	Q8N8A2
HTLVYIHPVEAAQTL	PRDM10	66	Q9NQV6
LDSHIHAYVNALLIP	PTPRZ1	2001	P23471
ENTEGLHHLYEIIRG	PPP4R3B	186	Q5MIZ7
RLYPLIHDVHTQLAG	PABPC1L	551	Q4VXU2
LTISPGLGHHDDYTQ	PLEKHM3	321	Q6ZWE6
VPTLSLLHYSTGVHE	GPR52	96	Q9Y2T5
LEILFTYHGSDLLPH	NBAS	741	A2RRP1
ALPGQYELVHTLVAH	DSTYK	166	Q6XUX3
TLLQPFSVDTYLHLH	GPR84	71	Q9NQS5
VEHIYELHNIGPSTI	ITGA8	821	P53708
ISLLTENDRHYHIPV	OTULINL	341	Q9NUU6
HTHIYLLETIPSEIQ	OASL	421	Q15646
YVIGFLHPLVHVSLL	OR5AC2	151	Q9NZP5
HDPHLLYTLSAVQIL	RABGGTB	91	P53611
PDHAHYTLGTVILLV	OPN4	66	Q9UHM6
PHGYIHVLSLTENIT	ITGB8	221	P26012
HAHISYLEPDTDLCL	MON1A	476	Q86VX9
HLHVIVGTLIPLVYE	ATM	1516	Q13315
GLPLSIEGHVHYLIQ	ATR	2611	Q13535
HIHYTGSLVDGRIID	FKBP11	61	Q9NYL4
PETYHHVLHSLLLAI	DOCK11	991	Q5JSL3
HVLETYHPGAVIRIL	FBXL4	141	Q9UKA2
LATGDDIYDVPHIRH	DSCAML1	61	Q8TD84
HSHLPLTTQYLESIE	FUT10	176	Q6P4F1
SIRVPESGEHYELHL	DPP8	866	Q6V1X1
HAVVFLLESPYITGH	CBR4	211	Q8N4T8
RDEHNYTLSIHELGP	AREL1	206	O15033
SPSEALLYALVHDHQ	ANKRD9	71	Q96BM1
YQNDLHLTPTLHLTG	CNTN2	951	Q02246
ASYIGHDTIVHLLLE	ANKS3	76	Q6ZW76
LHYDLFVHPNLTSLD	ERAP2	76	Q6P179
TPSLLVVLHVAYHEG	GJB7	86	Q6PEY0
SPYLEGILSQVIHLE	HEATR1	1776	Q9H583
LLHGLIHNVLPYVGT	FBXL5	316	Q9UKA1
STPTLIYLGHVLHIV	GJA3	86	Q9Y6H8
PDHYLVDHTLDGRVL	FASN	871	P49327
THHDRADPQYLLLLE	C1orf159	301	Q96HA4
IVDHSIAIYLLNPDG	SCO2	221	O43819
DIHETPSATHLDQYL	DYSF	726	O75923
HRQTLILPSHTLEYG	PKD1L1	736	Q8TDX9
SHGEDYAAPLELHVL	CDH16	311	O75309
QEYQDLLTPVLHHTT	PHKB	386	Q93100
IFEIEGLHYLPSLHI	LRRC72	101	A6NJI9
GYTSVTVPLLLHHLL	OR10C1	71	Q96KK4
YSIEQSHHAILTPLQ	PBOV1	71	Q9GZY1
VTAHTLEEGHYVIGP	GAREM2	61	Q75VX8
HLQDLTYSEIPQALH	SZT2	926	Q5T011
PAQLVSTYHHLESVI	SZT2	3406	Q5T011
ERLAYGITPENEHHL	SLC6A2	586	P23975
LHYLLLHTDGPLASS	SESN2	96	P58004
VNHLIHLIYDLDVAP	TRNT1	251	Q96Q11
ELESHRAVYIGVHVP	SLC4A7	36	Q9Y6M7
IQPVLEASGLSLHYE	SMCHD1	861	A6NHR9
DQLHQLYSHSLLPVD	STAT2	16	P52630
LHPDVNVYLGLTSEH	TEX14	536	Q8IWB6
DLHFVLYGVTPSLEH	PRDM14	201	Q9GZV8
ELTNLLNHPDHYVET	TAB2	486	Q9NYJ8
ALYLLHTQGLVPEHV	FER1L5	1661	A0AVI2
DQPTISYCGVHHELL	LRRTM3	526	Q86VH5
IHYSQLSAILPGLSH	PRAMEF14	361	Q5SWL7
YIITLHELLAHTPHE	RASGRF2	391	O14827
SPHGLYLTLQVEHLK	KIFC3	96	Q9BVG8
TETPFLLVLSYLHVH	STS	276	P08842
YPGSIAILERNEIHH	SHCBP1L	536	Q9BZQ2
RISTYLHLHSIPGEL	SLC41A2	431	Q96JW4
AIGPHDHILRVVEYT	HHIP	311	Q96QV1
PDYGHSVSDVELLLH	SPTBN5	3446	Q9NRC6
TLHGISPDVFTHVLY	ABTB1	321	Q969K4
SPLEGISHYHINLDE	ANKRD20A12P	121	Q8NF67
EALHLHYPIERGLVT	ACTRT1	66	Q8TDG2
ISLDHYIHLIHPVLS	CMKLR2	131	P46091
AYVELVHHIRESIPG	CDK5RAP1	421	Q96SZ6
LIYSLLEQHVDPHVL	ATP11B	926	Q9Y2G3
LIHYVLGPQHLRDVT	RAPGEF3	686	O95398
AIYLHAGPTAHELAV	TGFBRAP1	721	Q8WUH2
ILPLGIDDVSSLQHY	ZIM3	126	Q96PE6
YLITAHHTEVLPTAQ	ZSWIM5	286	Q9P217
SLFVLPHTDHLVGYI	TRAPPC11	171	Q7Z392
PHTDHLVGYIIRLEN	TRAPPC11	176	Q7Z392
HIELQGDLLHYSPTV	TAS1R1	126	Q7RTX1
YLHPGNTILHVDTIY	RBP3	186	P10745
TTHLLSASLDYLHPQ	SSH2	1121	Q76I76
LYPLETVLHRLHIQG	SLC25A46	331	Q96AG3
LRHLTTGHYLALTED	RYR3	286	Q15413
SLPELVHAVVLLAHY	SESN3	186	P58005
YHQGLKIDLETHSLP	STAT3	446	P40763
HPIDGYLSHTELAPL	SPARC	241	P09486
LIPLHNAASYGHVDI	TNKS	871	O95271
LISHQLVHTGEGPYE	ZNF587	311	Q96SQ5
LYNHLEEHEIGPSLY	TBC1D1	951	Q86TI0
VTIVHEIDHESPLYA	KCNJ16	251	Q9NPI9
TLGDAHIYLNHIEPL	TYMS	251	P04818
SYDRHGDHLQPLDLV	TRPV6	261	Q9H1D0
ASAIVAHDQHPEYLL	TMEM44	276	Q2T9K0
LLHVYTDGSVLLTHG	XDH	1021	P47989
LTEHLRDHTGVIPYE	ZNF404	146	Q494X3
ITSLLQHHLFGEDLP	UBR3	1656	Q6ZT12
LVPALGHYSQHSVLL	UEVLD	276	Q8IX04
AGHLNETYHLTLGLL	ZZEF1	2126	O43149
DLLIHKSIHTGEQPY	ZNF611	496	Q8N823
LISHQSIHIGERPYE	ZFP14	411	Q9HCL3
IPDEVLQTLLDHYSH	ZNF148	536	Q9UQR1
GGRESNIHLIPYIIH	UBR4	4981	Q5T4S7
QLGSSFYSHLPELHI	ZNF600	86	Q6ZNG1
GLPSHFHLQLSEIEF	TNNI3K	451	Q59H18
GETEVNLSELHPYLH	PTPRC	916	P08575
YTLHHLTNLPALREE	ZFYVE26	446	Q68DK2
LEGVFQHHQYLSPLE	VENTX	106	O95231
HRLEPLVLVQLSEHY	TMEM249	161	Q2WGJ8
LVGSSPHLPALHYDE	ZBED4	251	O75132
HIITYHEFAENPGLI	LPIN2	491	Q92539
YLVEEHGSVHNLSLP	MUS81	366	Q96NY9
DLTALSYLHEPAVLH	MYO5C	71	Q9NQX4