Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionGTPase regulator activity

RAPGEF6 AGAP7P AGAP4 AGAP6 ASAP1 SBF2

2.65e-04507366GO:0030695
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

RAPGEF6 AGAP7P AGAP4 AGAP6 ASAP1 SBF2

2.65e-04507366GO:0060589
GeneOntologyMolecularFunctionphospholipid binding

RAPGEF6 AGAP7P AGAP4 AGAP6 ASAP1 SBF2

4.02e-04548366GO:0005543
GeneOntologyCellularComponentcone cell pedicle

MPP4 HCN3

2.87e-055362GO:0044316
GeneOntologyCellularComponentmicrovillus membrane

CUBN PTPRH MSN

3.80e-0538363GO:0031528
MousePhenofused cornea and lens

AGAP7P CUBN AGAP4 AGAP6

2.33e-0724324MP:0001307
MousePhenoabnormal lens development

AGAP7P CUBN AGAP4 AGAP6

2.86e-0578324MP:0005545
DomainArfGap

AGAP7P AGAP4 AGAP6 ASAP1

2.99e-0729374SM00105
DomainARFGAP

AGAP7P AGAP4 AGAP6 ASAP1

2.99e-0729374PS50115
DomainArfGAP

AGAP7P AGAP4 AGAP6 ASAP1

2.99e-0729374IPR001164
DomainArfGap

AGAP7P AGAP4 AGAP6 ASAP1

2.99e-0729374PF01412
DomainANK

KANK4 TANC1 AGAP7P AGAP4 AGAP6 ASAP1

9.10e-06251376SM00248
DomainANK_REPEAT

KANK4 TANC1 AGAP7P AGAP4 AGAP6 ASAP1

9.52e-06253376PS50088
DomainAnkyrin_rpt-contain_dom

KANK4 TANC1 AGAP7P AGAP4 AGAP6 ASAP1

9.74e-06254376IPR020683
DomainANK_REP_REGION

KANK4 TANC1 AGAP7P AGAP4 AGAP6 ASAP1

9.74e-06254376PS50297
DomainAnkyrin_rpt

KANK4 TANC1 AGAP7P AGAP4 AGAP6 ASAP1

1.16e-05262376IPR002110
DomainPH_dom-like

AGAP7P NUMBL AGAP4 AGAP6 ASAP1 SBF2 MSN

1.74e-05426377IPR011993
DomainAnk

KANK4 TANC1 AGAP7P AGAP4 ASAP1

8.22e-05228375PF00023
Domain-

NUMBL AGAP4 AGAP6 ASAP1 SBF2 MSN

1.09e-043913762.30.29.30
Domain-

KANK4 TANC1 AGAP4 AGAP6 ASAP1

1.22e-042483751.25.40.20
DomainPH

AGAP7P AGAP4 AGAP6 ASAP1 SBF2

2.08e-04278375SM00233
DomainPH_DOMAIN

AGAP7P AGAP4 AGAP6 ASAP1 SBF2

2.11e-04279375PS50003
DomainPH_domain

AGAP7P AGAP4 AGAP6 ASAP1 SBF2

2.15e-04280375IPR001849
Domain-

ACACA HIBCH

7.83e-04213723.90.226.10
DomainClpP/crotonase-like_dom

ACACA HIBCH

7.83e-0421372IPR029045
DomainAnk_2

TANC1 AGAP4 AGAP6 ASAP1

8.37e-04215374PF12796
DomainPH

AGAP7P AGAP4 ASAP1 SBF2

1.06e-03229374PF00169
DomaincNMP

RAPGEF6 HCN3

2.06e-0334372SM00100
DomaincNMP_binding

RAPGEF6 HCN3

2.06e-0334372PF00027
DomaincNMP-bd_dom

RAPGEF6 HCN3

2.18e-0335372IPR000595
DomainCNMP_BINDING_3

RAPGEF6 HCN3

2.18e-0335372PS50042
DomaincNMP-bd-like

RAPGEF6 HCN3

2.57e-0338372IPR018490
Domain-

RAPGEF6 HCN3

4.07e-03483722.60.120.10
DomainRmlC-like_jellyroll

RAPGEF6 HCN3

4.58e-0351372IPR014710
DomainEGF_CA

FAT4 CUBN

1.26e-0286372PF07645
Pubmed

GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.

AGAP7P AGAP4 AGAP6

9.27e-08937312640130
Pubmed

AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors promotes dopamine release.

AGAP7P AGAP4 AGAP6

1.32e-071037320664521
Pubmed

AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase.

AGAP7P AGAP4 AGAP6

1.82e-071137315381706
Pubmed

The Endosome Localized Arf-GAP AGAP1 Modulates Dendritic Spine Morphology Downstream of the Neurodevelopmental Disorder Factor Dysbindin.

AGAP7P AGAP4 AGAP6

3.15e-071337327713690
Pubmed

GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity.

AGAP7P AGAP4 AGAP6

4.00e-071437322453919
Pubmed

Activation of somatostatin receptor II expression by transcription factors MIBP1 and SEF-2 in the murine brain.

TCF4 HIVEP2

3.30e-06337210207097
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

AGAP7P NUMBL AGAP4 AGAP6 ASAP1

1.17e-0528137528706196
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

DIP2C MFN2 TANC1 RAPGEF6 HIVEP2 ACACA COQ4 SBF2

1.72e-05110537835748872
Pubmed

Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.

TCF4 TANC1 AGAP7P STAG1 AGAP4 AGAP6

2.02e-0553637615840001
Pubmed

Exchangeable gene trap using the Cre/mutated lox system.

TCF4 TANC1 AGAP7P STAG1 AGAP4 AGAP6

2.06e-0553837610512203
Pubmed

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

RBM14 FAT4 FATE1 RUNX1T1 ACACA NUMBL

4.08e-0560837616713569
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

RBM14 A2M TANC1 RAPGEF6 ACAD11 MSN

5.91e-0565037638777146
Pubmed

E protein silencing by the leukemogenic AML1-ETO fusion protein.

TCF4 RUNX1T1

9.94e-051437215333839
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

A2M FAT4 ACACA HIBCH COQ4 MSN

1.33e-0475437635906200
Pubmed

TIF1gamma controls erythroid cell fate by regulating transcription elongation.

TCF4 RUNX1T1

1.67e-041837220603019
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

RBM14 TANC1 RAPGEF6 HIVEP2 ACACA NUMBL

2.73e-0486137636931259
Pubmed

LZTR1 is a regulator of RAS ubiquitination and signaling.

RAPGEF6 NUMBL MSN

3.37e-0412737330442766
Pubmed

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

MFN2 ACACA ACAD11 PMPCA HIBCH COQ4

4.02e-0492637620877624
Pubmed

LINC01554-Mediated Glucose Metabolism Reprogramming Suppresses Tumorigenicity in Hepatocellular Carcinoma via Downregulating PKM2 Expression and Inhibiting Akt/mTOR Signaling Pathway.

HIVEP2 PMPCA MSN

4.68e-0414237330809309
Pubmed

Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.

STAG1 SBF2

4.70e-043037219936222
Pubmed

Molecular mapping of developing dorsal horn-enriched genes by microarray and dorsal/ventral subtractive screening.

TCF4 RUNX1T1

5.35e-043237216516881
Pubmed

Ubiquitin-assisted phase separation of dishevelled-2 promotes Wnt signalling.

TANC1 ACAD11 NUMBL

6.74e-0416137336398662
Pubmed

A mitochondrial protein compendium elucidates complex I disease biology.

MFN2 ACACA ACAD11 PMPCA HIBCH COQ4

7.67e-04104737618614015
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

TANC1 PTPRH PMPCA NUMBL ASAP1 SBF2

7.75e-04104937627880917
Pubmed

Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.

MFN2 AGAP7P AGAP4 AGAP6

8.83e-0440537438187761
Pubmed

Transcription factor protein interactomes reveal genetic determinants in heart disease.

RBM14 RUNX1T1 ACACA ACAD11

9.33e-0441137435182466
Pubmed

Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.

RBM14 MFN2 ACACA

9.61e-0418237332239614
InteractionASAP3 interactions

TCF4 ACAD11 ASAP1

1.62e-0527373int:ASAP3
Cytoband10q11.23

AGAP7P AGAP6

3.28e-043337210q11.23
CytobandEnsembl 112 genes in cytogenetic band chr10q11

AGAP7P AGAP4 AGAP6

4.74e-04188373chr10q11
CytobandEnsembl 112 genes in cytogenetic band chr9q34

PMPCA COQ4 LCN15

2.29e-03325373chr9q34
Cytoband9q34.3

PMPCA LCN15

3.34e-031063729q34.3
CytobandEnsembl 112 genes in cytogenetic band chr3q22

ACAD11 STAG1

5.34e-03135372chr3q22
GeneFamilyArfGAPs

AGAP7P AGAP4 AGAP6 ASAP1

1.57e-0733274395
GeneFamilyAnkyrin repeat domain containing

KANK4 TANC1 AGAP7P AGAP4 AGAP6 ASAP1

1.26e-06242276403
GeneFamilyX-linked mental retardation|Rho GTPase activating proteins|BAR-PH domain containing

AGAP4 AGAP6 ASAP1

1.99e-06172731291
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

AGAP7P AGAP4 AGAP6 ASAP1 SBF2

1.20e-05206275682
GeneFamilyPDZ domain containing

RAPGEF6 MPP4

2.15e-021522721220
CoexpressionTHEODOROU_MAMMARY_TUMORIGENESIS

AGAP7P AGAP4 AGAP6

1.95e-0537373MM1121
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_F_DN

AGAP7P AGAP4 AGAP6

3.30e-0544373MM485
CoexpressionLAKE_ADULT_KIDNEY_C22_ENDOTHELIAL_CELLS_GLOMERULAR_CAPILLARIES

TCF4 HIBCH ASAP1 SBF2

4.13e-05137374M39241
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_bronchial_vessel|Children_(3_yrs) / Lineage, Cell type, age group and donor

A2M TCF4 FAT4 TANC1 RUNX1T1

2.33e-07163375977a970b1296234c22178420294cea73506ee02f
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

A2M TCF4 TANC1 RUNX1T1 ASAP1

5.52e-0719437590efdbd7f1c85fd7fd622b10340250b1d8fc1197
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

A2M TCF4 TANC1 RUNX1T1 ASAP1

5.52e-07194375df82cce5ebeb73740b02cf816c6df82253cfd566
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

TCF4 FAT4 TANC1 RUNX1T1 SBF2

5.52e-07194375b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCellIPF-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

A2M TCF4 FAT4 TANC1 RUNX1T1

5.95e-07197375f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCellKidney-Endothelial|Kidney / Skin and Kidney Cells in Lupus Nephritis Patients.

A2M TCF4 FATE1 ASAP1 MSN

6.25e-07199375b543f0686522df43737e9ffa5c9733e42b8a9f4d
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_bronchial_vessel-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

A2M TCF4 TANC1 RUNX1T1

9.99e-06163374ba7d02db0f0e2f9916ec8db52c067c87b6917c23
ToppCellEndothelial-endothelial_cell_of_bronchial_vessel|World / Lineage, Cell type, age group and donor

A2M TCF4 TANC1 RUNX1T1

1.05e-0516537484e553d699ac56df89a77248f7308b9133e1b683
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

A2M TCF4 FAT4 RUNX1T1

1.07e-05166374ec719368295133da2f7ff587c5329ed6db1dd56d
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

A2M FAT4 TANC1 RUNX1T1

1.15e-05169374c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCell3'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

A2M TCF4 ASAP1 MSN

1.26e-05173374b57d14e2c2368304cb903562d06ce8228f53857c
ToppCellnormal_Lung-Endothelial_cells-EPCs|normal_Lung / Location, Cell class and cell subclass

A2M TCF4 FATE1 RUNX1T1

1.35e-0517637471d1bd425772d89d8c550b909e0ec0e36ff22a7e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

A2M TCF4 FAT4 RUNX1T1

1.41e-051783745f779a66aa42d1d8e8af17b4a08d5dcc733efd4c
ToppCellCOVID-19-kidney-REN+Pericyte|kidney / Disease (COVID-19 only), tissue and cell type

A2M TCF4 CPM RUNX1T1

1.44e-05179374342c1cc4444f51b8dcb30d3adc98285a25669c6e
ToppCellCOVID-19-Heart-EC_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

A2M TCF4 FAT4 RUNX1T1

1.44e-051793742a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

A2M TCF4 RUNX1T1 ASAP1

1.61e-05184374688428103e8b19f45f2f65d70a0f30c904c8411c
ToppCellEndothelial-A-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

A2M TCF4 FAT4 RUNX1T1

1.64e-05185374dee0b7ba2f338f0979d2306aedf52ac35a36b60c
ToppCellEndothelial-A-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

A2M TCF4 FATE1 RUNX1T1

1.68e-05186374796cbae2a417502aaf0891fc9c382bbfd88967fe
ToppCell3'-Adult-LargeIntestine-Mesenchymal-Pericytes-Pericyte|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

A2M CPM RUNX1T1 MPP4

1.71e-05187374150023e6a50c9da461f2321074d2d5e96caafb06
ToppCellControl-Fibroblasts-Other_FB|Control / group, cell type (main and fine annotations)

A2M TCF4 FAT4 RUNX1T1

1.71e-05187374bd3739c4a52aa1ba5deffd778e113a9800f7e158
ToppCellChildren_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

A2M TCF4 FAT4 RUNX1T1

1.75e-05188374117dc80fa940e6aa1b0187a43fdde33f3fcb578f
ToppCellCOVID-19-kidney-AQP1+SLC14A1+EC|kidney / Disease (COVID-19 only), tissue and cell type

A2M TCF4 FAT4 RUNX1T1

1.82e-051903741519f34d31fe0817184c5865a0bc9f0cb479b1a4
ToppCellCOPD-Myeloid-Mast|Myeloid / Disease state, Lineage and Cell class

A2M DIP2C TANC1 CPM

1.82e-05190374379dbac19110b76079a7a53209569e060a852acb
ToppCellEndothelial-A-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

A2M TCF4 FAT4 RUNX1T1

1.86e-05191374f702dfe88a9b04091dae87df61b2b4f43525f86a
ToppCellControl-Endothelial-VE_Capillary_B|Control / Disease state, Lineage and Cell class

TCF4 FAT4 TANC1 RUNX1T1

1.86e-05191374322237793a1278bafb14e63cab688b353e352dcc
ToppCell343B-Endothelial_cells-Endothelial-B_(Artery)-|343B / Donor, Lineage, Cell class and subclass (all cells)

A2M TCF4 CUBN RUNX1T1

1.86e-051913741dfcff08e01e6a695953334342bcfde04ba005ad
ToppCell343B-Endothelial_cells-Endothelial-B_(Artery)|343B / Donor, Lineage, Cell class and subclass (all cells)

A2M TCF4 CUBN RUNX1T1

1.86e-0519137427a532a35d9e8822014f581fd56c4ca62e39f8fe
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

A2M TCF4 RUNX1T1 ASAP1

1.90e-0519237428eb3a5728e8901bcb5ba12f6b009f41b065fa37
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

DIP2C CUBN STAG1 SBF2

1.90e-05192374e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCellMesenchymal-matrix_fibroblast_1_cell|World / Lineage, Cell type, age group and donor

A2M TCF4 FAT4 RUNX1T1

1.94e-05193374acad568621ed677031797b8c2e34dafea798d681
ToppCellCOVID-19-Fibroblasts-Other_FB|COVID-19 / group, cell type (main and fine annotations)

A2M DIP2C FAT4 RUNX1T1

1.94e-05193374e6b75be08e33c1de079fb5c02f0b4468128b369c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

A2M TCF4 RUNX1T1 ASAP1

1.98e-05194374f76808666fb875fc787751cbfd924d9be20a8192
ToppCellChildren_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)|Children_(3_yrs) / Lineage, Cell type, age group and donor

A2M TCF4 FAT4 RUNX1T1

1.98e-0519437471ac69cdf7a08ca3ddfb5b492b14ac56b6cd5e5d
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

A2M TCF4 FAT4 RUNX1T1

1.98e-05194374b0c15e7e4bcf30856fb628dedd7ba82df33489f5
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

A2M TCF4 RUNX1T1 ASAP1

1.98e-05194374f5706ab6bc803606c4640ddd606617e4e797ccc9
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

A2M TCF4 RUNX1T1 ASAP1

1.98e-05194374a52c5906fce43c2f72cf7e463a3d15cde06431f6
ToppCellChildren_(3_yrs)-Endothelial|Children_(3_yrs) / Lineage, Cell type, age group and donor

TCF4 FAT4 TANC1 RUNX1T1

2.02e-05195374094cf6591daa5ffad36e44122b6f524a3a34c2fd
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

TCF4 FAT4 RUNX1T1 SBF2

2.02e-051953740e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

A2M TCF4 RUNX1T1 ASAP1

2.02e-0519537477e47d2e8b3eb7f7c9620369ccaf87581f923bdb
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M TCF4 RUNX1T1 ASAP1

2.06e-0519637448b4a9cea97a55190217deaf51bf867608c5a9a7
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

A2M TCF4 RUNX1T1 ASAP1

2.06e-051963748ad8efb631164b46f0c082572270188e5ead20bf
ToppCellCOVID-19-kidney-VWF+PLVAP+VCAM1+EC|kidney / Disease (COVID-19 only), tissue and cell type

A2M TCF4 RUNX1T1 ASAP1

2.06e-05196374ac2c4a325efa8497a755cd31fb6a9d94d8e3bf42
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

TCF4 FAT4 RUNX1T1 SBF2

2.06e-051963741450cb69c5bf469e97c03bf1890f6f7c54165b8a
ToppCellbackground-Endothelial_cells|background / Sample and Cell Type and Tumor Cluster (all cells)

TCF4 TANC1 RUNX1T1 ASAP1

2.06e-05196374e6fb0bfab1779ec64a8c35d01519eaafbf62e977
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

A2M TCF4 RUNX1T1 ASAP1

2.06e-051963749606ea7e42f707e69ea891b3521037613b9675f5
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M TCF4 RUNX1T1 ASAP1

2.06e-05196374473980c827443464d08a0be28c53e3536369b12a
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

A2M TANC1 RUNX1T1 ASAP1

2.06e-051963742b36b9a40fe415917afccff99ad9c3474e087d0d
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

A2M TCF4 RUNX1T1 ASAP1

2.06e-05196374ab7be3858deabbd1fc44e8b9da8ff49a50bf1fb1
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

A2M TCF4 RUNX1T1 ASAP1

2.06e-051963748f2031b1a9232c389517fbf3c29f47f9468b0077
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

A2M TCF4 FAT4 ASAP1

2.10e-05197374c10dd1aaec01fb662eac83dfde90e3e426665d65
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

A2M FAT4 RUNX1T1 ASAP1

2.10e-0519737485a8f1d18e0dd1d31341f5131eecd217553bf042
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

A2M TCF4 FAT4 ASAP1

2.10e-051973742844dbcd0a673ed81c99920aa45858651a00736d
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

A2M FAT4 RUNX1T1 ASAP1

2.10e-051973749b480f9c799a244bfee64487abd8a1bf07c9a3a2
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

A2M FAT4 RUNX1T1 ASAP1

2.10e-05197374e8e3ba791dfaa0fab35e0329a5e34376f9ee6143
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

A2M TCF4 RUNX1T1 ASAP1

2.14e-0519837407701c73137947ed4a27e225975329235bbb8734
ToppCellParenchymal-NucSeq|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations

DIP2C TANC1 ACACA STAG1

2.14e-051983741996373bdccc55aac347d349bd22f6aad6d0c668
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

A2M TCF4 RUNX1T1 ASAP1

2.14e-05198374b027a141ab531d0f5d6a26811a53427e7b0771dd
ToppCellASK428-Endothelial|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

A2M TCF4 FAT4 RUNX1T1

2.14e-05198374d69d0ff115298596173a4278897a65007a71f5df
ToppCellCOVID-19-kidney-AQP1+PLVAP+EC|kidney / Disease (COVID-19 only), tissue and cell type

A2M TCF4 RUNX1T1 ASAP1

2.14e-051983748689090bce9ab6e8f122426a404037e572c6713b
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

A2M TCF4 RUNX1T1 ASAP1

2.14e-05198374fa84bf8533d1b91d2c2bcf06b710670605072b89
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.3|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M TCF4 FAT4 RUNX1T1

2.14e-05198374d5990cab01de6e6f3757f5a50ef70ced711bb1fa
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

A2M TCF4 RUNX1T1 ASAP1

2.14e-051983748e45551224fbb30c0658ad47dd98335ecf165437
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

A2M TCF4 RUNX1T1 ASAP1

2.14e-05198374953630dbe3154b1b102b87de0feca2cbf124eabe
ToppCellFetal_29-31_weeks|World / Lineage, Cell type, age group and donor

DIP2C TCF4 FAT4 RUNX1T1

2.19e-051993745b9d355795dd03a22f0961dfd143425c367a4654
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

DIP2C ACACA STAG1 SBF2

2.19e-0519937494b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellMesenchymal|World / Lineage, Cell type, age group and donor

A2M TCF4 FAT4 RUNX1T1

2.19e-051993744bac110c2b3609f6ee5d0e3275da0824a6240270
ToppCellBronchial-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

A2M TCF4 FAT4 RUNX1T1

2.23e-05200374cae972324d1dfea6efeaf6013f265c7c6bb48db4
ToppCellControl_saline-Endothelial-Endothelial-Activated_Alv_Cap|Control_saline / Treatment groups by lineage, cell group, cell type

KANK4 TCF4 TANC1 MSN

2.23e-05200374be55cef682ba87250dad97689332c8820b3a7420
ToppCellControl_saline-Endothelial-Endothelial-Alv_Cap|Control_saline / Treatment groups by lineage, cell group, cell type

KANK4 TCF4 TANC1 MSN

2.23e-05200374abf4ba5fcb54cdeada0da1a8b956a30aa47679e4
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

A2M TCF4 RUNX1T1 ASAP1

2.23e-05200374b1be27d134a8633e3e7862c6a0d7be2001d387f0
ToppCellParenchymal-10x3prime_v2-Stromal-Peri/Epineurial_|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

KANK4 HIVEP2 NUMBL SPRYD3

2.23e-052003745ad3ea1cf1fcd4100966c5517bc7ed0a1af54317
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

A2M TCF4 RUNX1T1

2.08e-04139373b07929348ec9ad95d7bce33a7deac0938227b19f
ToppCellmetastatic_Brain-T/NK_cells-Naive_CD8+_T|T/NK_cells / Location, Cell class and cell subclass

TANC1 ACAD11 SPRYD3

2.45e-041473734f7a0c287721befeffabf95b8c5f9ff64149c7c1
ToppCellTCGA-Kidney|World / Sample_Type by Project: Shred V9

CUBN ACAD11 GAL3ST1

2.65e-04151373e31974c0d0a0c644205a0ee6013ab74a09d8a306
ToppCellControl-Stromal-Pericyte|Stromal / Disease state, Lineage and Cell class

TANC1 CPM ASAP1

3.08e-041593736f50c381cd8a26a5a90bf0ce909713cea96910d7
ToppCellTCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma-1|TCGA-Kidney / Sample_Type by Project: Shred V9

TCF4 FATE1 ACAD11

3.20e-041613736cacae4a759ace763597ee394cff498dc5d96f74
ToppCellControl-MAIT|World / Disease group and Cell class

RAPGEF6 NUMBL HCN3

3.31e-041633730ca4b835936b4f82217cbe57210c1dd90986c1d0
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

NUMBL AGAP6 SBF2

3.31e-041633730ab043b68e8739adcedda01165a3758cd0d22728
ToppCellfacs-Marrow-KLS-3m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

A2M CUBN HCN3

3.43e-041653734f95c2fe5ab4416c736fe0d1936695a2b26777eb
ToppCellnucseq-Immune-Hematopoietic-Granulocytic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

A2M DIP2C CPM

3.43e-0416537337615622c736e43260c38016e7c9e565ac97a3e8
ToppCellfacs-Marrow-KLS-3m-Hematologic-megakaryocyte-erythroid_progenitor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

A2M CUBN HCN3

3.43e-041653733e913b49a868fdd5589200ae3e9be77c0938ba14
ToppCellnucseq-Immune-Hematopoietic-Granulocytic-Mast/Basophil|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

A2M DIP2C CPM

3.43e-04165373640bb71e74a61df2fcb01ceeabe4c493ef836b21
ToppCellnucseq-Immune-Hematopoietic|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

A2M DIP2C CPM

3.43e-04165373f3df74b5763130c71c0a482a3a23f6b22acc2892
ToppCellAdult-Endothelial-endothelial_cell_of_artery-D231|Adult / Lineage, Cell type, age group and donor

TCF4 FAT4 RUNX1T1

3.62e-04168373aca34c51758c65925ad24110294a72b2dea6db72
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

A2M TCF4 ASAP1

3.62e-0416837337249f38f8f04ec5743097259de67b106ca2b02f
ToppCell390C-Myeloid-Dendritic-pDC|390C / Donor, Lineage, Cell class and subclass (all cells)

PRMT9 TCF4 MPP4

3.62e-041683735a2e7a52b7330dce30823695a7b9b26bc47a69ce
ToppCellControl-Mast_cells|Control / group, cell type (main and fine annotations)

A2M DIP2C CPM

3.68e-04169373fdb9abca1d0f4fdc32dd8ac6231651ef34aa5afb
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

A2M TCF4 TANC1

3.68e-041693736614c9851537e4c21b1e45ff0cc3bad07ef9d034
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

A2M TCF4 TANC1

3.68e-04169373665b958f4a720ca369a8a0abc7fbe8b6e13c8ce5
ToppCelldroplet-Lung-30m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l5|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RAPGEF6 CPM HCN3

3.68e-041693731de3ae36d3b60e961bfd9f7bdc37867b82a0417f
ToppCellControl-Myeloid-Mast|Control / Disease state, Lineage and Cell class

A2M DIP2C CPM

3.75e-041703739a14deb7f7cd4a49c217eba4023f7bf1dec6c902
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M TCF4 RUNX1T1

3.75e-041703731a568efcff9c39b3f709b55a05d24710450a2657
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

TANC1 CPM ACACA

3.75e-04170373a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCellControl-Mast_cells-Mast_cells|Control / group, cell type (main and fine annotations)

A2M DIP2C CPM

3.75e-04170373c80f6d29096c372da95a8407f402349ff1bb7018
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

A2M TCF4 RUNX1T1

3.75e-0417037366d41d794790e621d72ac37af995510537103c9c
ToppCellControl-Myeloid-Mast|World / Disease state, Lineage and Cell class

A2M DIP2C CPM

3.81e-04171373ed8e61d524f4cddc6084b261175df54d2a64a60f
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

TCF4 FAT4 RUNX1T1

3.81e-041713731597459c971d6befa991d59dc66b41b6a522f797
ToppCellEndothelial-A-IPF_03|World / lung cells shred on cell class, cell subclass, sample id

A2M TCF4 FAT4

3.88e-04172373a3201773a25832e92dd113fad165f1ecd37f5e91
ToppCellControl-MAIT|Control / Disease group and Cell class

RAPGEF6 NUMBL HCN3

3.88e-04172373552bc62e8e8bb0ac1cd0452f4410a3af087787eb
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

A2M TANC1 RUNX1T1

4.01e-04174373f90ca117b729436cf452e2ddcec26ba525c5c13b
Diseasecerebral palsy (implicated_via_orthology)

AGAP7P AGAP4 AGAP6

1.99e-0710363DOID:1969 (implicated_via_orthology)
DiseaseFuchs endothelial corneal dystrophy

KANK4 TCF4

6.47e-0510362Orphanet_98974
Diseaseuric acid measurement

DIP2C TCF4 FAT4 TANC1 CUBN SBF2

8.75e-05610366EFO_0004761
Diseasealbuminuria

TCF4 CUBN SBF2

2.07e-0494363EFO_0004285
Diseasecolorectal cancer

TCF4 TANC1 CUBN ASAP1 SBF2

7.88e-04604365MONDO_0005575
DiseaseCharcot-Marie-Tooth disease

MFN2 SBF2

1.21e-0342362cv:C0007959
Diseaseurinary albumin to creatinine ratio

TCF4 CUBN SBF2

1.35e-03179363EFO_0007778
Diseasewellbeing measurement

TCF4 FAT4 RAPGEF6 HIVEP2 STAG1

1.44e-03692365EFO_0007869
Diseasehomocysteine measurement

MFN2 CUBN

1.45e-0346362EFO_0004578
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

TCF4 TANC1

1.64e-0349362DOID:0060037 (implicated_via_orthology)
DiseaseSmall cell carcinoma of lung

DIP2C RUNX1T1

1.99e-0354362C0149925
Diseaselobe attachment

FAT4 HIVEP2 ASAP1

2.05e-03207363EFO_0007667
DiseaseIschemic stroke, fibrinogen measurement

RAPGEF6 STAG1

2.06e-0355362EFO_0004623, HP_0002140
Diseasefibrinogen measurement, factor VII measurement

RAPGEF6 STAG1

2.29e-0358362EFO_0004619, EFO_0004623
Diseasecytokine measurement

PRMT9 CPM ACACA ASAP1

2.33e-03461364EFO_0004873

Protein segments in the cluster

PeptideGeneStartEntry
VGDHQALVHRPGMVR

AKAP14

156

Q86UN6
VEVGEDLHMHHVRDR

AGAP4

56

Q96P64
MAVECAEIRRHHRVG

PRMT9

306

Q6P2P2
RRGHVESHDFVGCIM

FAT4

4121

Q6V0I7
GARIGLAEEIRHMFH

ACACA

1721

Q13085
GRIHHCMRTVGLAER

ACAD11

631

Q709F0
DVMGRGHARLVHVEE

A2M

711

P01023
VEVGEDLHMHHVRDR

AGAP6

56

Q5VW22
GHVEVEESRGMHVCE

NUMBL

86

Q9Y6R0
HGHELRPGRALVVEM

RBM14

56

Q96PK6
CMRGHDFHEGVRAVL

HIBCH

336

Q6NVY1
GLHGTRQEEMIDHRL

RUNX1T1

331

Q06455
GIVAMHIETLEAVHR

SBF2

846

Q86WG5
RHSLMVGTHREDGVA

TCF4

446

P15884
HEMTGDILVARIIHG

MPP4

171

Q96JB8
HEEHRGMLREDAVLE

MSN

176

P26038
RAIRPTEEGGLHVHM

LCN15

61

Q6UWW0
EQHLVQHDRDMARGV

HCN3

571

Q9P1Z3
LHRHIEEGLGRNMSD

MFN2

466

O95140
ASHVVHGRILEMDIE

CUBN

1886

O60494
HANERMRTICIDGGH

GAL3ST1

336

Q99999
NMHGDETVGRELLLH

CPM

81

P14384
RHDMVAVLGETTGHR

COQ4

66

Q9Y3A0
VMLMERGHLQDGDHV

DIP2C

1016

Q9Y2E4
VEVGEDLHMHHVRDR

AGAP7P

56

Q5VUJ5
ECSGIHREMGVHISR

ASAP1

476

Q9ULH1
HMEIAGLLRAHAEQG

KANK4

976

Q5T7N3
RMLRESGHGDAHLQE

FATE1

86

Q969F0
ERHGDVVVVRPMRDH

CTU2

296

Q2VPK5
MVLAGVGVEHEHLVD

PMPCA

251

Q10713
IVMVHEHRELDRSGT

RAPGEF6

396

Q8TEU7
VIEHVDHSGMRPLDR

TANC1

1236

Q9C0D5
HREKRMGIDLVHDEV

TEKT3

201

Q9BXF9
VGMHSLGEEVRLHLN

SPRYD3

186

Q8NCJ5
GVRHAVRGLMEEDAE

STAG1

1181

Q8WVM7
VQEGHVEVEHHGRML

HIVEP2

601

P31629
THGHLRVTLVGEEVM

PTPRH

941

Q9HD43