Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainGYF

GIGYF2 GIGYF1

1.86e-053472SM00444
DomainGYF

GIGYF2 GIGYF1

1.86e-053472PS50829
DomainGYF

GIGYF2 GIGYF1

1.86e-053472PF02213
Domain-

GIGYF2 GIGYF1

1.86e-0534723.30.1490.40
DomainGYF

GIGYF2 GIGYF1

3.71e-054472IPR003169
DomainSPOC

DIDO1 SPEN

9.24e-056472PF07744
DomainSPOC_C

DIDO1 SPEN

9.24e-056472IPR012921
DomainNucleotide-bd_a/b_plait

RBM5 SRRT UPF3B SPEN EIF4B

4.62e-04258475IPR012677
Domain-

SMARCA2 TJP2 GNA12 ABCC12 LRRK1 DHX38 YLPM1

2.46e-037464773.40.50.300
DomainIon_trans_dom

CACNA1A TRPM8 KCNA7

2.95e-03114473IPR005821
DomainIon_trans

CACNA1A TRPM8 KCNA7

2.95e-03114473PF00520
Domain-

RBM5 UPF3B SPEN EIF4B

3.26e-032444743.30.70.330
DomainP-loop_NTPase

SMARCA2 TJP2 GNA12 ABCC12 LRRK1 DHX38 YLPM1

5.00e-03848477IPR027417
DomainChannel_four-helix_dom

CACNA1A KCNA7

9.06e-0357472IPR027359
Domain-

CACNA1A KCNA7

9.06e-03574721.20.120.350
PathwayREACTOME_METABOLISM_OF_RNA

RBM5 SNIP1 SRRT UPF3B EDC3 EIF4B DHX38 RPS10

8.03e-05612348MM15547
PathwayREACTOME_MRNA_SPLICING

RBM5 SNIP1 SRRT UPF3B DHX38

1.11e-04201345MM15411
PathwayREACTOME_MRNA_SPLICING

RBM5 SNIP1 SRRT UPF3B DHX38

1.43e-04212345M14033
PathwayREACTOME_METABOLISM_OF_RNA

RBM5 SNIP1 SRRT UPF3B EDC3 EIF4B DHX38 RPS10

2.57e-04724348M16843
PathwayREACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA

RBM5 SNIP1 SRRT UPF3B DHX38

4.93e-04277345MM15414
PathwayREACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA

RBM5 SNIP1 SRRT UPF3B DHX38

5.43e-04283345M13087
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

SMARCA2 TJP2 SRRT GIGYF2 DIDO1 PRPF38B ZNF318 TOPORS YTHDC1 SPEN UBAP2L NIPBL EIF4B ZNF516 YLPM1

7.87e-14774481515302935
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

RBM5 SRRT GIGYF2 DIDO1 UPF3B YTHDC1 SPEN UBAP2L DROSHA EIF4B DHX38 YLPM1 RPS10 NCOA5

2.73e-12807481422681889
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

ARFGEF3 TJP2 SNIP1 DIDO1 PRPF38B FAT1 UPF3B YTHDC1 SPEN EIF4B

5.91e-11361481026167880
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

DNAJC9 SMARCA2 RBM5 SNIP1 SRRT DIDO1 PRPF38B ZNF318 EDC3 LZTS2 YTHDC1 SPEN NIPBL DROSHA EIF4B DHX38

7.84e-111497481631527615
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

TJP2 SRRT GIGYF2 SCHIP1 UPF3B GIGYF1 EDC3 LZTS2 UBAP2L DROSHA EIF4B RPS10 TMED8

1.01e-091038481326673895
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

SMARCA2 TJP2 GIGYF2 DIDO1 ZNF318 SPEN UBAP2L NIPBL DHX38 YLPM1 RPS10

1.13e-09653481122586326
Pubmed

Human transcription factor protein interaction networks.

SMARCA2 SRRT GIGYF2 DIDO1 FAT1 ZNF318 GIGYF1 EDC3 SPEN UBAP2L NIPBL ZNF516 YLPM1 RPS10

4.77e-091429481435140242
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

DNAJC9 RBM5 SNIP1 SRRT DIDO1 ZNF318 YTHDC1 SPEN NIPBL DHX38 YLPM1 RPS10 NCOA5

1.41e-081294481330804502
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

RBM5 SRRT DIDO1 PRPF38B GNA12 YTHDC1 SPEN NIPBL DROSHA YLPM1 RPS10 NCOA5

1.92e-081082481238697112
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

TJP2 SRRT DIDO1 GIGYF1 EDC3 YTHDC1 SPEN UBAP2L NIPBL

2.62e-0850348916964243
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

GIGYF2 DIDO1 PRPF38B UPF3B ZNF318 EDC3 UBAP2L NIPBL EIF4B DHX38 YLPM1

4.50e-08934481133916271
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

DNAJC9 CACNA1A GIGYF2 DIDO1 PDE4A ZNF318 UBAP2L NIPBL NISCH ZNF516 YLPM1

6.14e-08963481128671696
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

DNAJC9 TJP2 SRRT DIDO1 LZTS2 TOPORS YTHDC1 SPEN EIF4B DHX38 RPS10 NCOA5

9.85e-081257481236526897
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

ARFGEF3 UPF3B ZNF318 LZTS2 TOPORS SPEN DROSHA DHX38 ZNF516

9.90e-0858848938580884
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

DNAJC9 SMARCA2 SRRT DIDO1 PRPF38B EDC3 YTHDC1 NIPBL DHX38 YLPM1 NCOA5

1.03e-071014481132416067
Pubmed

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.

DNAJC9 SMARCA2 SRRT ZNF318 UBAP2L NISCH DHX38 YLPM1

1.49e-0744048834244565
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

DNAJC9 RBM5 GIGYF2 PRPF38B MAML2 EDC3 NIPBL EIF4B DHX38 YLPM1 RPS10 NCOA5

1.77e-071327481232694731
Pubmed

Molecular basis for GIGYF-Me31B complex assembly in 4EHP-mediated translational repression.

GIGYF2 GIGYF1 EDC3

2.06e-07948331439631
Pubmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

GIGYF2 ZNF318 GIGYF1 EDC3 LZTS2 SPEN

2.06e-0718448632908313
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

DNAJC9 SMARCA2 RBM5 DIDO1 PRPF38B UPF3B ZNF318 SPEN NIPBL EIF4B ZNF516

2.39e-071103481134189442
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

DNAJC9 RBM5 TJP2 SNIP1 SRRT DIDO1 PRPF38B UPF3B LZTS2 UBAP2L DROSHA YLPM1

2.51e-071371481236244648
Pubmed

TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.

SRRT GIGYF2 GNA12 ZNF318 EDC3 LZTS2 YTHDC1 EIF4B YLPM1 RPS10

4.29e-07922481027609421
Pubmed

Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.

DNAJC9 TJP2 SRRT UBAP2L DROSHA EIF4B DHX38 RPS10 NCOA5

5.05e-0771448928302793
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

SRRT GIGYF2 DIDO1 ZNF318 SPEN UBAP2L NIPBL EIF4B YLPM1 RPS10

5.85e-07954481036373674
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

TJP2 GIGYF2 DIDO1 ZNF318 LZTS2 SPEN UBAP2L YLPM1

7.94e-0754948838280479
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

DNAJC9 RBM5 SRRT DIDO1 YTHDC1 EIF4B DHX38 YLPM1 RPS10 NCOA5

8.11e-07989481036424410
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

SMARCA2 TJP2 GIGYF2 PRPF38B ABCC12 UPF3B EDC3 EIF4B DHX38 YLPM1

9.37e-071005481019615732
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

TJP2 SRRT GIGYF2 ZNF318 SPEN UBAP2L NIPBL YLPM1 RPS10 NCOA5

1.11e-061024481024711643
Pubmed

SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.

DNAJC9 RBM5 SNIP1 PRPF38B SPEN NCOA5

1.27e-0625148631076518
Pubmed

SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.

SRRT YTHDC1 SPEN UBAP2L EIF4B RPS10

1.49e-0625848637794589
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

SMARCA2 RBM5 SRRT SPEN DHX38 YLPM1 RPS10 NCOA5

1.64e-0660548828977666
Pubmed

A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.

GIGYF2 LRRK1 SPEN UBAP2L EIF4B DHX38 ZNF516

1.71e-0642048728065597
Pubmed

The FHA domain proteins DAWDLE in Arabidopsis and SNIP1 in humans act in small RNA biogenesis.

SNIP1 DROSHA

1.87e-06248218632581
Pubmed

Severe acute respiratory syndrome coronavirus nonstructural protein 2 interacts with a host protein complex involved in mitochondrial biogenesis and intracellular signaling.

GIGYF2 DIDO1 SPEN

1.98e-061848319640993
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

DNAJC9 RBM5 TJP2 GIGYF2 YTHDC1 DROSHA DHX38 RPS10 NCOA5

2.07e-0684748935850772
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

ARFGEF3 TJP2 SRRT GIGYF2 GIGYF1 EDC3 KCNA7 EIF4B MAP3K2

2.36e-0686148936931259
Pubmed

A Noncanonical Role of Fructose-1, 6-Bisphosphatase 1 Is Essential for Inhibition of Notch1 in Breast Cancer.

SMARCA2 SRRT GIGYF2 UBAP2L EIF4B RPS10

2.69e-0628648632041737
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

DNAJC9 RBM5 SRRT GIGYF2 UPF3B SPEN UBAP2L NIPBL DHX38 RPS10 NCOA5

2.94e-061425481130948266
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

PRPF38B FAT1 ZNF318 GIGYF1 MAML2 EDC3 LZTS2 ZNF516

4.27e-0668948836543142
Pubmed

IQCJ-SCHIP1, a novel fusion transcript encoding a calmodulin-binding IQ motif protein.

SCHIP1 IQCJ-SCHIP1

5.59e-06348217045569
Pubmed

Tagging genes with cassette-exchange sites.

RBM5 GIGYF2 DIDO1 DROSHA TMED8 NCOA5

6.67e-0633548615741177
Pubmed

The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins.

TJP2 SNIP1 SRRT UBAP2L EIF4B

9.00e-0620348535012549
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

ARFGEF3 RBM5 TJP2 FAT1 ZNF318 MARVELD2 EDC3 SPEN

1.03e-0577748835844135
Pubmed

Schwannomin-interacting Protein 1 Isoform IQCJ-SCHIP1 Is a Multipartner Ankyrin- and Spectrin-binding Protein Involved in the Organization of Nodes of Ranvier.

SCHIP1 IQCJ-SCHIP1

1.12e-05448227979964
Pubmed

4EHP and GIGYF1/2 Mediate Translation-Coupled Messenger RNA Decay.

GIGYF2 GIGYF1

1.12e-05448233053355
Pubmed

Ars2 maintains neural stem-cell identity through direct transcriptional activation of Sox2.

SRRT DROSHA

1.12e-05448222198669
Pubmed

Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

DNAJC9 DIP2C SPEN NISCH

1.23e-0510248410231032
Pubmed

CK2-regulated schwannomin-interacting protein IQCJ-SCHIP-1 association with AnkG contributes to the maintenance of the axon initial segment.

SCHIP1 IQCJ-SCHIP1

1.86e-05548225950943
Pubmed

Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling.

GIGYF2 GIGYF1

1.86e-05548212771153
Pubmed

Schwannomin-interacting protein-1 isoform IQCJ-SCHIP-1 is a late component of nodes of Ranvier and axon initial segments.

SCHIP1 IQCJ-SCHIP1

1.86e-05548218550753
Pubmed

The adapter protein GRB10 is an endogenous negative regulator of insulin-like growth factor signaling.

GIGYF2 GIGYF1

1.86e-05548216037382
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

DNAJC9 SRRT GIGYF2 DIDO1 UPF3B UBAP2L NIPBL EIF4B DHX38 RPS10

1.92e-051415481028515276
Pubmed

Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.

GIGYF2 ZNF318 UBAP2L DROSHA DHX38

2.10e-0524248534011540
Pubmed

Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.

GIGYF2 YTHDC1 SPEN RPS10 NCOA5

2.50e-0525148528077445
Pubmed

The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.

GIGYF2 DIDO1 ZNF318 UBAP2L EIF4B

2.75e-0525648533397691
Pubmed

Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation.

SRRT DROSHA

2.79e-05648219632182
Pubmed

Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis.

GIGYF2 GIGYF1

2.79e-05648220878056
Pubmed

GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression.

GIGYF2 GIGYF1

2.79e-05648228698298
Pubmed

GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling.

GIGYF2 GIGYF1

2.79e-05648219744960
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

SRRT GIGYF2 DIDO1 GIGYF1 DROSHA NISCH DHX38

2.92e-0565048738777146
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

TJP2 GIGYF2 GIGYF1 EDC3 LZTS2 MAP3K2

3.35e-0544648624255178
Pubmed

The N-terminal domain of the Schaaf-Yang syndrome protein MAGEL2 likely has a role in RNA metabolism.

GIGYF2 UBAP2L EIF4B

3.59e-054648334265304
Pubmed

Human Regulatory Protein Ki-1/57 Is a Target of SUMOylation and Affects PML Nuclear Body Formation.

DNAJC9 TJP2 DIDO1 UPF3B

3.59e-0513448428695742
Pubmed

mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.

RBM5 TJP2 SRRT GIGYF2 UBAP2L

3.80e-0527448534244482
Pubmed

PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.

DNAJC9 GIGYF2 UPF3B YTHDC1 UBAP2L EIF4B RPS10

3.82e-0567848730209976
Pubmed

GIGYF1/2-Driven Cooperation between ZNF598 and TTP in Posttranscriptional Regulation of Inflammatory Signaling.

GIGYF2 GIGYF1

3.90e-05748230917308
Pubmed

A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development.

GIGYF2 GIGYF1

3.90e-05748222751931
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

DIDO1 ZNF318 SPEN DHX38 YLPM1

4.43e-0528348530585729
Pubmed

The protein interaction landscape of the human CMGC kinase group.

TJP2 DIDO1 LZTS2 YTHDC1 UBAP2L DROSHA ZNF516

4.46e-0569548723602568
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

SMARCA2 SRRT PRPF38B UPF3B LZTS2 TOPORS YTHDC1 EIF4B RPS10

4.52e-05124748927684187
Pubmed

The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer.

SRRT GIGYF2 YLPM1 RPS10

5.16e-0514748428977470
Pubmed

JNK1/2-dependent phosphorylation of angulin-1/LSR is required for the exclusive localization of angulin-1/LSR and tricellulin at tricellular contacts in EpH4 epithelial sheet.

TJP2 MARVELD2

5.19e-05848224889144
Pubmed

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.

DNAJC9 SNIP1 SRRT PRPF38B UPF3B YTHDC1 RPS10

5.24e-0571348729802200
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

TJP2 GIGYF2 EDC3 SPEN UBAP2L EIF4B YLPM1

5.77e-0572448736232890
Pubmed

Analysis of HIV-1 Gag protein interactions via biotin ligase tagging.

GIGYF2 UBAP2L EIF4B

5.82e-055448325631074
Pubmed

Gain of LINC00624 Enhances Liver Cancer Progression by Disrupting the Histone Deacetylase 6/Tripartite Motif Containing 28/Zinc Finger Protein 354C Corepressor Complex.

SRRT UBAP2L

6.67e-05948232869873
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

SMARCA2 TJP2 SNIP1 DIDO1 PRPF38B YTHDC1 UBAP2L NIPBL DHX38

6.93e-05131848930463901
Pubmed

A protein-RNA interaction atlas of the ribosome biogenesis factor AATF.

SRRT EIF4B YLPM1 RPS10

7.52e-0516248431363146
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

DNAJC9 SRRT DIDO1 UPF3B UBAP2L DROSHA NCOA5

7.75e-0575948735915203
Pubmed

Proximity labeling reveals dynamic changes in the SQSTM1 protein network.

GIGYF2 EDC3 LZTS2 UBAP2L RPS10

8.15e-0532248539098523
Pubmed

Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.

CACNA1A SRRT GIGYF1

9.24e-056348317672918
Pubmed

P/Q Type Calcium Channel Cav2.1 Defines a Unique Subset of Glomeruli in the Mouse Olfactory Bulb.

CACNA1A PDE4A

1.02e-041148230233329
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

SRRT DIDO1 SPEN DHX38 YLPM1

1.07e-0434148532971831
Pubmed

CHIP as a membrane-shuttling proteostasis sensor.

DNAJC9 GIGYF1 UBAP2L

1.16e-046848329091030
Pubmed

De novo genic mutations among a Chinese autism spectrum disorder cohort.

GIGYF2 YTHDC1

1.22e-041248227824329
Pubmed

High-resolution mapping of mouse chromosome 8 identifies an evolutionary chromosomal breakpoint.

CACNA1A FAT1

1.22e-04124829680377
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

DIP2C GNA12 FAT1 PDE4A LRRK1 SPEN NISCH ZNF516

1.24e-04110548835748872
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

SMARCA2 SNIP1 FAT1 ZNF318 GIGYF1 LZTS2 TOPORS DROSHA

1.32e-04111648831753913
Pubmed

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.

DNAJC9 DYNC2I1 EDC3 NISCH DHX38

1.43e-0436348525036637
Pubmed

A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells.

TJP2 SNIP1 NIPBL

1.43e-047348322094256
Pubmed

Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5.

SRRT GIGYF1

1.44e-041348211239002
Pubmed

TRIM65 regulates microRNA activity by ubiquitination of TNRC6.

SRRT UPF3B EDC3 DROSHA YLPM1

1.45e-0436448524778252
Pubmed

Dynamic protein-protein interaction wiring of the human spliceosome.

RBM5 SNIP1 SRRT DHX38

1.60e-0419748422365833
Pubmed

Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase.

SRRT EIF4B DHX38 RPS10

1.63e-0419848424337577
Pubmed

SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.

RBM5 TJP2 GIGYF1 EIF4B DHX38

1.72e-0437848534315543
Pubmed

RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.

SRRT GIGYF2 NISCH YLPM1

1.76e-0420248424639526
Pubmed

Identification of the SOX2 Interactome by BioID Reveals EP300 as a Mediator of SOX2-dependent Squamous Differentiation and Lung Squamous Cell Carcinoma Growth.

SMARCA2 SPEN NIPBL

2.10e-048348328794006
Pubmed

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

RBM5 DIDO1 FAT1 UPF3B LZTS2 NIPBL ARSI NCOA5

2.36e-04121548815146197
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ARFGEF3 GIGYF2 SPEN UBAP2L NISCH

2.42e-0440748512693553
Pubmed

Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.

SRRT GIGYF2 YTHDC1 UBAP2L YLPM1 RPS10

2.43e-0464148636057605
InteractionLINC02910 interactions

TJP2 SNIP1 DYNC2I1 GIGYF2 DIDO1 PRPF38B YTHDC1 NCOA5

4.88e-1195478int:LINC02910
InteractionANAPC15 interactions

TJP2 SNIP1 GIGYF2 DIDO1 PRPF38B DHX38 NCOA5

1.80e-08128477int:ANAPC15
InteractionBMI1 interactions

SMARCA2 ARFGEF3 SRRT GIGYF2 DIDO1 YTHDC1 SPEN UBAP2L DROSHA YLPM1 RPS10 NCOA5

2.48e-086594712int:BMI1
InteractionSRPK2 interactions

ARFGEF3 TJP2 SNIP1 SRRT DIDO1 PRPF38B UPF3B YTHDC1 SPEN DROSHA EIF4B RPS10

6.25e-087174712int:SRPK2
InteractionYAP1 interactions

SMARCA2 TJP2 GIGYF2 DIDO1 GNA12 ZNF318 LZTS2 SPEN UBAP2L DROSHA EIF4B MAP3K2 YLPM1 RPS10

1.14e-0710954714int:YAP1
InteractionUQCR11 interactions

TJP2 SNIP1 DIDO1 PRPF38B YLPM1

1.46e-0753475int:UQCR11
InteractionANKRD50 interactions

TJP2 SNIP1 DIDO1 PRPF38B YTHDC1 YLPM1

1.85e-07108476int:ANKRD50
InteractionIFI27L1 interactions

TJP2 SNIP1 DIDO1 PRPF38B NCOA5

4.12e-0765475int:IFI27L1
InteractionSNRPC interactions

SRRT GIGYF2 DIDO1 ZNF318 GIGYF1 YTHDC1 SPEN YLPM1 NCOA5

6.78e-07440479int:SNRPC
InteractionSIRT7 interactions

SMARCA2 TJP2 GIGYF2 DIDO1 ZNF318 SPEN UBAP2L NIPBL DHX38 YLPM1 RPS10

8.34e-077444711int:SIRT7
InteractionPSENEN interactions

TJP2 SNIP1 DIDO1 PRPF38B DHX38

1.24e-0681475int:PSENEN
InteractionSIRT6 interactions

DNAJC9 SMARCA2 DYNC2I1 SRRT FAT1 ZNF318 UBAP2L NISCH DHX38 YLPM1

1.47e-066284710int:SIRT6
InteractionSRSF6 interactions

RBM5 SNIP1 SRRT PRPF38B TOPORS YTHDC1 SPEN RPS10 NCOA5

2.05e-06503479int:SRSF6
InteractionEZH1 interactions

TJP2 SNIP1 DIDO1 PRPF38B DHX38

2.34e-0692475int:EZH1
InteractionSNRPB interactions

SNIP1 SRRT GIGYF2 DIDO1 ZNF318 GIGYF1 YTHDC1 YLPM1 NCOA5

2.57e-06517479int:SNRPB
InteractionSSRP1 interactions

DNAJC9 SNIP1 SRRT DIDO1 YTHDC1 NIPBL DROSHA DHX38 YLPM1 NCOA5

3.20e-066854710int:SSRP1
InteractionMECP2 interactions

SMARCA2 RBM5 SRRT DIDO1 PRPF38B GNA12 YTHDC1 SPEN NIPBL DROSHA YLPM1 RPS10 NCOA5

5.04e-0612874713int:MECP2
InteractionSAP18 interactions

SMARCA2 SNIP1 SRRT PRPF38B UPF3B TOPORS YTHDC1

6.35e-06305477int:SAP18
InteractionIFI6 interactions

TJP2 SNIP1 DIDO1 PRPF38B

7.54e-0654474int:IFI6
InteractionTPX2 interactions

TJP2 SNIP1 DIDO1 PRPF38B YLPM1 NCOA5

7.60e-06204476int:TPX2
InteractionJPH3 interactions

TJP2 SNIP1 PRPF38B NCOA5

8.12e-0655474int:JPH3
InteractionSMG7 interactions

RBM5 TJP2 ZNF318 EDC3 LZTS2 UBAP2L YLPM1

8.52e-06319477int:SMG7
InteractionNAA40 interactions

GIGYF2 DIDO1 PRPF38B UPF3B ZNF318 EDC3 UBAP2L NIPBL EIF4B DHX38 YLPM1

1.16e-059784711int:NAA40
InteractionMARF1 interactions

RBM5 EDC3 LZTS2 UBAP2L NISCH

1.18e-05128475int:MARF1
InteractionSNRPA interactions

SNIP1 SRRT DIDO1 ZNF318 GIGYF1 YTHDC1 YLPM1 NCOA5

1.40e-05482478int:SNRPA
InteractionFBP1 interactions

SMARCA2 SRRT GIGYF2 DIDO1 UBAP2L EIF4B RPS10

1.50e-05348477int:FBP1
InteractionPHF19 interactions

RBM5 SNIP1 LZTS2 YTHDC1

1.68e-0566474int:PHF19
InteractionEED interactions

SMARCA2 RBM5 TJP2 SRRT DIDO1 LZTS2 SPEN NIPBL DROSHA ZNF516 YLPM1 RPS10 NCOA5

1.76e-0514454713int:EED
InteractionCIT interactions

DNAJC9 SMARCA2 RBM5 TJP2 DIDO1 PRPF38B UPF3B TAPT1 UBAP2L NIPBL DHX38 RPS10 NCOA5

1.83e-0514504713int:CIT
InteractionMEN1 interactions

DNAJC9 RBM5 TJP2 SRRT GIGYF2 DIDO1 YTHDC1 SPEN DROSHA DHX38 YLPM1

1.86e-0510294711int:MEN1
InteractionCEBPA interactions

DNAJC9 SMARCA2 RBM5 DIDO1 PRPF38B UPF3B ZNF318 SPEN NIPBL EIF4B ZNF516 NCOA5

2.03e-0512454712int:CEBPA
InteractionSQSTM1 interactions

ARFGEF3 GIGYF2 PDE4A UPF3B LRRK1 EDC3 LZTS2 UBAP2L NIPBL EIF4B MAP3K2 RPS10

2.23e-0512574712int:SQSTM1
InteractionCPEB1 interactions

GIGYF2 GIGYF1 EDC3 UBAP2L RPS10

2.24e-05146475int:CPEB1
InteractionCYCS interactions

TJP2 SNIP1 DIDO1 PRPF38B YTHDC1 DHX38

2.25e-05247476int:CYCS
InteractionDHX40 interactions

ZNF318 YTHDC1 DROSHA DHX38 YLPM1 NCOA5

2.35e-05249476int:DHX40
InteractionAKR7L interactions

SRRT GIGYF2 UPF3B DHX38

2.38e-0572474int:AKR7L
InteractionMALL interactions

TJP2 SNIP1 DIDO1 PRPF38B YLPM1

2.55e-05150475int:MALL
InteractionCPSF6 interactions

SRRT DIDO1 ZNF318 YTHDC1 UBAP2L YLPM1 RPS10 NCOA5

2.62e-05526478int:CPSF6
InteractionHABP4 interactions

DNAJC9 TJP2 DIDO1 UPF3B TOPORS

3.08e-05156475int:HABP4
InteractionCLUH interactions

TJP2 SRRT DIDO1 ABCC12 UBAP2L EIF4B

3.20e-05263476int:CLUH
InteractionODF2 interactions

TJP2 PRPF38B GIGYF1 LRRK1 LZTS2

3.27e-05158475int:ODF2
InteractionOBSL1 interactions

DNAJC9 TJP2 SRRT PRPF38B YTHDC1 SPEN UBAP2L NIPBL YLPM1 NCOA5

3.51e-059024710int:OBSL1
InteractionTMEM14B interactions

TJP2 SNIP1 DIDO1 PRPF38B DHX38 NCOA5

4.45e-05279476int:TMEM14B
InteractionTNRC6A interactions

TJP2 GIGYF2 GIGYF1 EDC3 LZTS2 UBAP2L

4.54e-05280476int:TNRC6A
InteractionSIPA1L1 interactions

TJP2 GIGYF2 GIGYF1 EDC3 LZTS2

5.18e-05174475int:SIPA1L1
InteractionSRSF7 interactions

SNIP1 DYNC2I1 SRRT DIDO1 YTHDC1 SPEN NCOA5

5.36e-05425477int:SRSF7
InteractionTANC2 interactions

SMARCA2 SNIP1 GIGYF2 GIGYF1

5.48e-0589474int:TANC2
InteractionGIGYF1 interactions

GIGYF2 GIGYF1 EDC3 LZTS2 UBAP2L

5.62e-05177475int:GIGYF1
InteractionDHX8 interactions

RBM5 SNIP1 ZNF318 SPEN DHX38 YLPM1

5.73e-05292476int:DHX8
InteractionZFP36 interactions

GIGYF2 GIGYF1 EDC3 LZTS2 UBAP2L

6.25e-05181475int:ZFP36
InteractionSP7 interactions

SMARCA2 SRRT ZNF318 NIPBL ZNF516 YLPM1

7.16e-05304476int:SP7
InteractionKHSRP interactions

SMARCA2 SNIP1 NIPBL DROSHA EIF4B YLPM1

7.69e-05308476int:KHSRP
InteractionCYB561D1 interactions

YTHDC1 TMED8

7.94e-056472int:CYB561D1
InteractionSERBP1 interactions

DNAJC9 TJP2 SRRT GIGYF2 DIDO1 UPF3B EDC3 TOPORS UBAP2L EIF4B RPS10 TMED8

8.00e-0514324712int:SERBP1
InteractionSMC5 interactions

SRRT GIGYF2 DIDO1 ZNF318 SPEN UBAP2L NIPBL EIF4B YLPM1 RPS10

8.37e-0510004710int:SMC5
InteractionEFTUD2 interactions

DNAJC9 SMARCA2 SNIP1 SRRT GIGYF2 DIDO1 UPF3B UBAP2L NIPBL EIF4B DHX38 RPS10

8.96e-0514494712int:EFTUD2
InteractionSNRNP40 interactions

RBM5 SNIP1 SRRT ZNF318 YTHDC1 SPEN DHX38 NCOA5

1.01e-04637478int:SNRNP40
InteractionFBXW11 interactions

RBM5 DYNC2I1 LZTS2 YTHDC1 UBAP2L EIF4B RPS10

1.05e-04473477int:FBXW11
InteractionTRIM66 interactions

FAT1 ZNF318 GIGYF1 LZTS2 DROSHA

1.12e-04205475int:TRIM66
InteractionRBM39 interactions

DNAJC9 TJP2 SRRT UBAP2L DROSHA EIF4B DHX38 YLPM1 RPS10 NCOA5

1.18e-0410424710int:RBM39
InteractionLOC254896 interactions

FAT1 EDC3 NISCH

1.37e-0443473int:LOC254896
InteractionCLK3 interactions

SNIP1 SRRT PRPF38B TOPORS YTHDC1

1.56e-04220475int:CLK3
InteractionKRTAP19-7 interactions

TJP2 SNIP1 DIDO1 PRPF38B

1.59e-04117474int:KRTAP19-7
InteractionZC3H18 interactions

SNIP1 SRRT TRPM8 PRPF38B TOPORS YTHDC1 SPEN RPS10 NCOA5

1.65e-04877479int:ZC3H18
InteractionPYHIN1 interactions

DNAJC9 GIGYF2 YTHDC1 SPEN RPS10 NCOA5

1.75e-04358476int:PYHIN1
InteractionCNOT9 interactions

GIGYF2 ZNF318 GIGYF1 LZTS2 UBAP2L

1.96e-04231475int:CNOT9
InteractionH2AJ interactions

TJP2 SNIP1 DIDO1 PRPF38B

2.18e-04127474int:H2AJ
InteractionKHDRBS1 interactions

SMARCA2 YTHDC1 DROSHA DHX38 YLPM1 NCOA5

2.18e-04373476int:KHDRBS1
InteractionSRSF12 interactions

SNIP1 GIGYF1 EDC3 RPS10

2.38e-04130474int:SRSF12
InteractionGAGE5 interactions

TJP2 SNIP1 DIDO1

2.42e-0452473int:GAGE5
InteractionGNL2 interactions

DNAJC9 TJP2 SNIP1 PRPF38B DHX38 RPS10

2.63e-04386476int:GNL2
InteractionEIF4E2 interactions

GIGYF2 GIGYF1 EDC3 LZTS2 UBAP2L

2.63e-04246475int:EIF4E2
InteractionTERF2IP interactions

RBM5 SNIP1 DIDO1 ZNF318 SPEN NIPBL DHX38

2.71e-04552477int:TERF2IP
InteractionSAA1 interactions

SNIP1 DIDO1 YLPM1

2.71e-0454473int:SAA1
InteractionCHD4 interactions

SMARCA2 RBM5 SNIP1 SRRT GIGYF2 SPEN YLPM1 RPS10 NCOA5

2.72e-04938479int:CHD4
InteractionPRNP interactions

TJP2 PRPF38B FAT1 ZNF318 GIGYF1 MAML2 EDC3 LZTS2 EIF4B ZNF516

2.78e-0411584710int:PRNP
InteractionCFAP141 interactions

TJP2 DIDO1 PRPF38B

2.86e-0455473int:CFAP141
InteractionTNIP2 interactions

SRRT GIGYF2 GNA12 ZNF318 EDC3 LZTS2 YTHDC1 EIF4B YLPM1

3.04e-04952479int:TNIP2
InteractionMAGOH interactions

DNAJC9 SNIP1 UPF3B YTHDC1 EIF4B

3.63e-04264475int:MAGOH
InteractionMAGI1 interactions

TJP2 GIGYF2 GIGYF1 EDC3

3.80e-04147474int:MAGI1
InteractionMAGEL2 interactions

GIGYF2 UBAP2L EIF4B

3.89e-0461473int:MAGEL2
InteractionSNIP1 interactions

SMARCA2 SNIP1 SRRT TOPORS YTHDC1 NIPBL

3.97e-04417476int:SNIP1
InteractionAIF1 interactions

SNIP1 YLPM1

4.08e-0413472int:AIF1
InteractionABT1 interactions

LZTS2 TOPORS SPEN DROSHA NISCH RPS10

4.28e-04423476int:ABT1
InteractionCGN interactions

TJP2 GIGYF2 GIGYF1 LZTS2

4.31e-04152474int:CGN
InteractionRNPS1 interactions

SNIP1 SRRT UPF3B TOPORS YTHDC1 DHX38

4.39e-04425476int:RNPS1
InteractionDVL3 interactions

TJP2 SNIP1 DIDO1 YTHDC1 RPS10

4.75e-04280475int:DVL3
InteractionCPEB4 interactions

SMARCA2 GIGYF1 EDC3 UBAP2L

4.76e-04156474int:CPEB4
InteractionZC3H13 interactions

DNAJC9 SRRT SCHIP1 DHX38

4.99e-04158474int:ZC3H13
InteractionVCPIP1 interactions

ABCC12 ZNF318 EDC3 YTHDC1

5.48e-04162474int:VCPIP1
InteractionPCNX3 interactions

SNIP1 TRPM8 YTHDC1

5.59e-0469473int:PCNX3
InteractionHNRNPUL2 interactions

DNAJC9 SNIP1 SRRT YTHDC1 DROSHA

5.66e-04291475int:HNRNPUL2
InteractionKIF9 interactions

SMARCA2 RBM5 LZTS2

5.83e-0470473int:KIF9
InteractionKIF20A interactions

SMARCA2 TJP2 GIGYF2 DIDO1 ZNF318 LRRK1 UBAP2L YLPM1 RPS10

6.30e-041052479int:KIF20A
InteractionFAM184A interactions

SMARCA2 LRRK1 LZTS2

6.33e-0472473int:FAM184A
InteractionRAD18 interactions

DNAJC9 RBM5 SNIP1 PRPF38B SPEN NCOA5

6.43e-04457476int:RAD18
InteractionSRSF4 interactions

RBM5 SNIP1 TOPORS YTHDC1 RPS10

6.50e-04300475int:SRSF4
InteractionEIF4ENIF1 interactions

GIGYF1 EDC3 LZTS2 UBAP2L NISCH

6.50e-04300475int:EIF4ENIF1
InteractionB9D2 interactions

ZNF318 YLPM1 NCOA5

6.59e-0473473int:B9D2
InteractionFASN interactions

RBM5 GIGYF2 MAML2 EDC3 NIPBL EIF4B YLPM1 RPS10 NCOA5

6.74e-041062479int:FASN
GeneFamilyRNA binding motif containing

RBM5 SPEN EIF4B

4.70e-03213293725
CoexpressionSCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN

SMARCA2 TJP2 DYNC2I1 GIGYF2 LZTS2 UBAP2L TM9SF1 EIF4B

1.93e-06467488M1347
CoexpressionSCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN

SMARCA2 TJP2 DYNC2I1 GIGYF2 LZTS2 UBAP2L TM9SF1 EIF4B

2.52e-06484488MM999
CoexpressionOSMAN_BLADDER_CANCER_DN

SMARCA2 CACNA1A SNIP1 DIDO1 MAML2 NISCH RPS10

1.27e-05431487M16858
CoexpressionGSE35435_RESTING_VS_IL4_TREATED_MACROPHAGE_DN

TRPM8 SCHIP1 ZNF318 TM9SF1 ZNF516

3.15e-05199485M9543
CoexpressionMULLIGHAN_NPM1_SIGNATURE_3_UP

RBM5 TJP2 TRPM8 GNA12 SCHIP1 NIPBL

3.25e-05335486M10277
ToppCellH1299-infected-SARSCoV2|infected / Cell line, Condition and Strain

RBM5 DYNC2I1 PRPF38B UPF3B YTHDC1 NISCH

6.88e-081974860fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
DrugChenodiol [474-25-9]; Down 200; 10.2uM; MCF7; HT_HG-U133A

DYNC2I1 SRRT DIDO1 GNA12 ZNF516 YLPM1

3.74e-061994867433_DN
Diseaseresponse to corticosteroid

SMARCA2 IQCJ-SCHIP1

1.02e-0329482GO_0031960
Diseaseesophagus squamous cell carcinoma (is_implicated_in)

FAT1 SPEN

2.45e-0345482DOID:3748 (is_implicated_in)
DiseaseSalivary Gland Neoplasms

FAT1 SPEN

2.67e-0347482C0036095
Diseasemigraine disorder

CACNA1A TJP2 DIP2C TRPM8

2.70e-03357484MONDO_0005277
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

GIGYF2 GIGYF1

2.90e-0349482DOID:0060037 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
ATYEGDARREDKERR

CACNA1A

1011

O00555
EEEGRARSFSRGRRK

ARSI

531

Q5FYB1
EDARRDGEIRYSIRD

FAT1

1061

Q14517
RRRGEEQRDSFEGER

LZTS2

586

Q9BRK4
RGERRFEKSARRDGA

GIGYF1

161

O75420
AYRRGDRGGARDLLE

LRRK1

61

Q38SD2
SERGDEDRERRYRER

DYNC2I1

176

Q8WVS4
RGYSDSAERAERERQ

PDE4A

46

P27815
DGRNGRDARDSRDIR

NCOA5

41

Q9HCD5
YDDSRIRRRGSDIDN

MAP3K2

321

Q9Y2U5
EYEERDRRSSGDHRR

NIPBL

1116

Q6KC79
EIDTYERRSGTRSRG

EDC3

221

Q96F86
ERSGRYGSIIDRDDR

RBM5

11

P52756
RSSDDRRGDRYDDYR

RBM5

41

P52756
GRYERGRAESSDRER

MAML2

56

Q8IZL2
RPEDESGRDYRERER

UPF3B

336

Q9BZI7
DPARRGRFYDDARRE

KCNA7

41

Q96RP8
EFDFRDRDDERGYRR

GIGYF2

256

Q6Y7W6
DRDDERGYRRVRSGS

GIGYF2

261

Q6Y7W6
DLVREGSRGRASDFR

ARFGEF3

1086

Q5TH69
RRRSSGSRDERYRSD

DIP2C

76

Q9Y2E4
QGRASEDRRRERERG

DIDO1

2106

Q9BTC0
RERRAGSGARDAERE

GNA12

21

Q03113
GVRREASDGEVRRGY

DNAJC9

21

Q8WXX5
RSRNRDRRYDEVPSD

MARVELD2

6

Q8N4S9
GRLDIYGERRDATRS

IGFN1

421

Q86VF2
DKDRDDRSFGRDRNR

EIF4B

176

P23588
RYGGRDRYDDRGSRD

EIF4B

251

P23588
ERGRSPDRRRQDSRY

DROSHA

251

Q9NRR4
SERERGSRRRHRDGD

SNIP1

6

Q8TAD8
RGSRQRRDVDYSDAL

SMARCA2

1306

P51531
ERDQRGYRDDRSPAR

SCHIP1

106

P0DPB3
DERDQRGYRDDRSPA

IQCJ-SCHIP1

181

B3KU38
DLDQRGRRRSFAERY

ABCC12

11

Q96J65
SDYDRSRERDERRRG

SRRT

21

Q9BXP5
REWDRGRERRSRGEY

SRRT

41

Q9BXP5
GRERRSRGEYRDYDR

SRRT

46

Q9BXP5
RLTRGEADRDTYRRS

RPS10

116

P46783
RRERDSDGDRAARAR

ZNF516

541

Q92618
DRDRSRGRSIDQDYE

TJP2

236

Q9UDY2
KENRDRDRDYSRRRG

UBAP2L

121

Q14157
EGRYERRLDGASDNR

SPEN

126

Q96T58
RRLDGASDNRERAYE

SPEN

131

Q96T58
ERGRRRDRDYDKERG

PRPF38B

361

Q5VTL8
QRDRYRLDDGRRVRD

NISCH

1401

Q9Y2I1
RDRDRSVRGKYSDDT

DHX38

251

Q92620
RLCDRDRDRGERGRY

YTHDC1

711

Q96MU7
HRDRDRDRGVIDYDR

YLPM1

1716

P49750
RDRGVIDYDRDRFDR

YLPM1

1721

P49750
GARVRNIEDGGRYRD

TOPORS

266

Q9NS56
GFYESDRRRERRRGR

TAPT1

51

Q6NXT6
FRRGFRKEDRNGRDE

TRPM8

531

Q7Z2W7
RGESRADYARDGRGD

ZNF318

111

Q5VUA4
VERGSRSSLRGRYGE

TMED8

261

Q6PL24
TSVERRSDRRRGDDG

TM9SF1

211

O15321