Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
MousePheno	osteoarthritis	HSPG2 PLCG2 ATP7A	2.58e-05	21	39	3	MP:0003560
Domain	EF-hand_5	FKBP10 CAPN3	1.72e-03	25	46	2	PF13202
Domain	IG_LIKE	MR1 HSPG2 PTPRU MYOM1 AMIGO3	6.95e-03	491	46	5	PS50835
Domain	Ig-like_dom	MR1 HSPG2 PTPRU MYOM1 AMIGO3	7.67e-03	503	46	5	IPR007110
Pubmed	ATM-dependent nuclear accumulation of IKK-alpha plays an important role in the regulation of p73-mediated apoptosis in response to cisplatin.	ATM CHUK	1.87e-06	2	48	2	17700524
Pubmed	[P53-independent apoptosis through a novel ATM/IKK-alpha/p73-mediated apoptotic pathway].	ATM CHUK	5.59e-06	3	48	2	18575226
Pubmed	Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency.	ATM TDP2	1.12e-05	4	48	2	32060399
Pubmed	Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli.	ATM CHUK	1.12e-05	4	48	2	16497931
Pubmed	Loss of Function Genetic Screen Identifies ATM Kinase as a Positive Regulator of TLR3-Mediated NF-κB Activation.	ATM CHUK	1.86e-05	5	48	2	32731169
Pubmed	Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations.	ATM INO80	1.86e-05	5	48	2	29759113
Pubmed	Associations Between Cancer Predisposition Testing Panel Genes and Breast Cancer.	RAD51D ATM	1.86e-05	5	48	2	28418444
Pubmed	ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage.	ATM CHUK	2.79e-05	6	48	2	14966265
Pubmed	Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner.	TNKS1BP1 PPP1R12C	6.67e-05	9	48	2	12080061
Pubmed	Development of immunoglobulin lambda-chain-positive B cells, but not editing of immunoglobulin kappa-chain, depends on NF-kappaB signals.	ATM CHUK	8.33e-05	10	48	2	19412180
Pubmed	ATM- and NEMO-dependent ELKS ubiquitination coordinates TAK1-mediated IKK activation in response to genotoxic stress.	ATM CHUK	8.33e-05	10	48	2	20932476
Pubmed	The mouse Rhl1 and Rhag genes: sequence, organization, expression, and chromosomal mapping.	PTPRU AKR7L	1.22e-04	12	48	2	10495887
Pubmed	Localisation of specific heparan sulfate proteoglycans during the proliferative phase of brain development.	HSPG2 GPC3	1.22e-04	12	48	2	12761845
Pubmed	Spatiotemporal Localisation of Heparan Sulphate Proteoglycans throughout Mouse Lens Morphogenesis.	HSPG2 GPC3	1.68e-04	14	48	2	37408198
Pubmed	Transcription precedes loss of Xist coating and depletion of H3K27me3 during X-chromosome reprogramming in the mouse inner cell mass.	UBA1 ATP7A	2.50e-04	17	48	2	21471155
Pubmed	Structural basis and sequence rules for substrate recognition by Tankyrase explain the basis for cherubism disease.	TNKS1BP1 PPP1R12C	2.50e-04	17	48	2	22153077
Pubmed	Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation.	UBA1 ATP7A	2.50e-04	17	48	2	19571810
Pubmed	Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease.	INO80 MYOM1	2.50e-04	17	48	2	29371594
Pubmed	Hereditary Ataxia Overview	MTCL1 ATM TDP2	2.84e-04	92	48	3	20301317
Pubmed	COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.	ATP7A CHUK	3.14e-04	19	48	2	25355947
Pubmed	Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human.	PTPRU AKR7L	3.49e-04	20	48	2	9828140
Pubmed	Altered heparan sulfate structure in Glce(-/-) mice leads to increased Hedgehog signaling in endochondral bones.	HSPG2 GPC3	3.85e-04	21	48	2	26116392
Pubmed	Failure of extra-embryonic progenitor maintenance in the absence of dosage compensation.	UBA1 ATP7A	4.63e-04	23	48	2	22573614
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	TNKS1BP1 TACC2 UBA1 MTCL1 TXLNG	6.36e-04	503	48	5	16964243
Pubmed	Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk.	RAD51D ATM	8.45e-04	31	48	2	19690177
Pubmed	STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1.	TNKS1BP1 MTCL1	8.45e-04	31	48	2	28089446
Pubmed	Genetic mapping of the human and mouse phospholipase C genes.	DLD PLCG2	9.58e-04	33	48	2	8672127
Pubmed	The spatiotemporal expression pattern of Syndecans in murine embryonic teeth.	HSPG2 GPC3	1.02e-03	34	48	2	32220631
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	WDR74 TACC2 ZNF423 PPP1R12C CAPN3	1.03e-03	560	48	5	21653829
Pubmed	Tagging genes with cassette-exchange sites.	CDC42BPG BRF1 STRBP ZNF423	1.18e-03	335	48	4	15741177
Pubmed	Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC).	FKBP10 DLD	1.20e-03	37	48	2	16396496
Pubmed	Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate.	HSPG2 GPC3	1.20e-03	37	48	2	32201365
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	DLD TNKS1BP1 TACC2 BRF1 TDP2	1.28e-03	588	48	5	38580884
Cytoband	15q15.1	INO80 CAPN3	1.12e-03	47	48	2	15q15.1
Cytoband	6p21.1	OARD1 TMEM151B	3.21e-03	80	48	2	6p21.1
Cytoband	16q22.1	NRN1L FCSK	5.97e-03	110	48	2	16q22.1
ToppCell	356C-Myeloid-Dendritic-pDC\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	FUZ FKBP10 MTCL1 GPC3 STRBP	8.86e-07	163	48	5	ae9c5eb19657ea94b7f2357cbc8679acd697b8fe
ToppCell	356C-Myeloid-Dendritic-pDC\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	FUZ FKBP10 MTCL1 GPC3 STRBP	9.13e-07	164	48	5	fed26f4ac36a2b0722bc7b9f91659c5e0cf4d53a
Disease	cortical thickness	MR1 ENO4 HSPG2 TACC2 MTCL1 SSH2 STRBP ZNF423	3.94e-04	1113	48	8	EFO_0004840
Disease	multisite chronic pain	ZCCHC4 PPCDC AMIGO3	5.03e-04	95	48	3	EFO_0010100
Disease	Malignant tumor of breast	RAD51D ATM	8.86e-04	27	48	2	cv:C0006142
Disease	Breast neoplasm	RAD51D ATM	8.86e-04	27	48	2	cv:C1458155
Disease	Familial cancer of breast	RAD51D ATM	8.86e-04	27	48	2	cv:C0346153
Disease	Breast Cancer, Familial	RAD51D ATM	1.09e-03	30	48	2	C0346153

Protein segments in the cluster

Peptide	Gene	Start	Entry
TILGGLGLRMGSSDC	AKR7L	56	Q8NHP1
RAEDACGGTMRGSSG	CSMD3	236	Q7Z407
LGLDGRCSIQMGAAG	AFDN-DT	146	Q9Y6Z5
LCMLRVGLGTPDSEG	AMIGO3	11	Q86WK7
EGDGVLELVVRGMTC	ATP7A	561	Q04656
IEGAGASGGRRMACL	RAD51D	281	O75771
IVRCDERGSMGTSGE	HSPG2	876	P98160
IGVGSEMCREEGGEG	MTCL1	1816	Q9Y4B5
MASELGARDDGGCTE	INO80	1	Q9ULG1
TSLMLGLGRQGLGCD	CDC42BPG	896	Q6DT37
GVTDLSMPRIGCGLD	OARD1	111	Q9Y530
CMRDALLAEGRGGGL	OVOS1	26	Q6IE37
DEDECIGGSGDGMIK	GPC3	501	P51654
EMRERLGTGGFGNVC	CHUK	16	O15111
GEMLAVSGCVGATRG	MROH6	246	A6NGR9
CMETGGKDGTFLVRE	PLCG2	551	P16885
AGVDGLRVGMGCGSI	IMPDH1	316	P20839
RSEEMGLILGICAGG	PTPRU	741	Q92729
ADVLGCMAEGRGGLR	FCSK	611	Q8N0W3
DGMGITGVEGVFRRC	ATM	2916	Q13315
IEGLDTGLQGMCVGE	FKBP10	436	Q96AY3
MCSAGELLRGGDGGE	FAM241A	1	Q8N8J7
GCVLDVCMGGGDRDI	FCGBP	4306	Q9Y6R7
GIICSLMRGGIAERG	APBA1	766	Q02410
AEDEGIICVEGMAGG	DLD	366	P09622
MEEEGGGRSCGTTRE	ENO4	1	A6NNW6
IERGSLMGCSIDDGT	CAPN3	256	P20807
MGEEGTGGTVHLLCL	FUZ	1	Q9BT04
RMIGCELLEDGSTTG	MR1	116	Q95460
ECLIRLGDSMGRGGE	NRN1L	51	Q496H8
LGDSMGRGGELETIC	NRN1L	56	Q496H8
CRLLAEHGGGMDSLT	PPP1R12C	276	Q9BZL4
VLMDLAGLGTRCGGA	TMEM151B	391	Q8IW70
GGCGSGSMLLDRERP	SLITRK3	876	O94933
DQGGRTLCGVMRIGL	STRBP	76	Q96SI9
LVCGDEGLGAMAEVG	PPCDC	171	Q96CD2
MQRAGSSGGRGECDI	PLPPR4	1	Q7Z2D5
GTGGETQMLVGCADR	WDR74	51	Q6RFH5
MEELGGGRNESCRLS	SSH2	676	Q76I76
MEGGLGRAVCLLTGA	SPR	1	P35270
GGLSLRDMNLTGCLE	TNKS1BP1	1196	Q9C0C2
MELGSCLEGGREAAE	TDP2	1	O95551
TLEIRKMGSCDGEGL	TACC2	741	O95359
VEGDLGGMCEERKVG	SNX19	336	Q92543
GLGCGEGGEIIVTDM	UBA1	491	P22314
MTGRVCRGCGGTDIE	BRF1	1	Q92994
VEAEGSAGCRGSSGM	ZCCHC4	11	Q9H5U6
TQMIGDGCDLGLGEE	ZNF423	116	Q2M1K9
EIGTMEEAGICGLGV	TXLNG	36	Q9NUQ3
GREGETMSLGCRVVI	MYOM1	416	P52179