Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	TOR signaling	SESN3 LAMTOR1 TIPRL USP9X SEC13	9.57e-06	181	33	5	GO:0031929
GeneOntologyCellularComponent	GATOR2 complex	SESN3 SEC13	1.58e-04	12	33	2	GO:0061700
GeneOntologyCellularComponent	Seh1-associated complex	SESN3 SEC13	2.86e-04	16	33	2	GO:0035859
Domain	Znf_FYVE_PHD	RUFY2 ING5 PCLO	2.19e-03	147	33	3	IPR011011
Domain	-	RUFY2 ING5 DTX3L PCLO	7.77e-03	449	33	4	3.30.40.10
Domain	SH3_9	NEB UBASH3A	8.36e-03	78	33	2	PF14604
Domain	Znf_RING/FYVE/PHD	RUFY2 ING5 DTX3L PCLO	8.38e-03	459	33	4	IPR013083
Pathway	REACTOME_MITOTIC_PROMETAPHASE	BUB3 NME7 PCM1 SEC13 HDAC8	6.12e-05	202	30	5	MM15362
Pathway	REACTOME_MITOTIC_PROMETAPHASE	BUB3 NME7 PCM1 SEC13 HDAC8	6.41e-05	204	30	5	M4217
Pathway	REACTOME_GENE_EXPRESSION_TRANSCRIPTION	ING5 SESN3 RNMT LAMTOR1 CPSF2 INTS7 USP9X SEC13 HDAC8	1.90e-04	1022	30	9	MM15436
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	DAPK3 LAMTOR1 CPSF2 BUB3 USP9X WNK3 PCM1 PAK5 NAT10	1.96e-07	963	33	9	28671696
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	ZC3H14 BRD8 TIPRL BUB3 USP9X PCM1 NAT10	7.04e-07	549	33	7	38280479
Pubmed	The X-linked deubiquitinase USP9X is an integral component of centrosome.	USP9X PCM1	2.62e-06	3	33	2	28620049
Pubmed	SNX17 Recruits USP9X to Antagonize MIB1-Mediated Ubiquitination and Degradation of PCM1 during Serum-Starvation-Induced Ciliogenesis.	USP9X PCM1	2.62e-06	3	33	2	31671755
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	BRD8 LAMTOR1 USP9X PCM1 SEC13	8.99e-06	300	33	5	28561026
Pubmed	Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.	DARS1 RNMT NEB BUB3 USP9X NAT10 SEC13	1.19e-05	844	33	7	25963833
Pubmed	Deubiquitylase USP9X maintains centriolar satellite integrity by stabilizing pericentriolar material 1 protein.	USP9X PCM1	1.31e-05	6	33	2	30584065
Pubmed	HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.	DARS1 TIPRL BUB3 NME7 USP9X SEC13	1.45e-05	571	33	6	37167062
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	DARS1 NIBAN2 CPSF2 USP9X NAT10	1.47e-05	332	33	5	32786267
Pubmed	Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.	DARS1 RNMT TIPRL CPSF2 BUB3 GFAP USP9X SEC13	2.72e-05	1335	33	8	29229926
Pubmed	In vivocharacterization of the aspartyl-tRNA synthetase DARS: Homing in on the leukodystrophy HBSL.	DARS1 GFAP	3.13e-05	9	33	2	27816769
Pubmed	A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export.	DARS1 LAMTOR1 BUB3 RETSAT USP9X	3.25e-05	392	33	5	33144569
Pubmed	KSHV Viral Protein Kinase Interacts with USP9X to Modulate the Viral Lifecycle.	USP9X SEC13	3.91e-05	10	33	2	36995092
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	DARS1 CPSF2 BUB3 RETSAT NAT10 SEC13	4.94e-05	711	33	6	33022573
Pubmed	The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1.	SESN3 SEC13	5.73e-05	12	33	2	25263562
Pubmed	Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFβ-mediated axonogenesis.	GFAP USP9X	5.73e-05	12	33	2	23861879
Pubmed	Nomenclature guidelines for X-linked mental retardation.	WNK3 HDAC8	6.77e-05	13	33	2	1605216
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	TIPRL INTS7 WNK3 PCM1 PCLO	7.07e-05	462	33	5	31138677
Pubmed	USP45 and Spindly are part of the same complex implicated in cell migration.	GFAP USP9X WNK3 PCM1	7.13e-05	235	33	4	30258100
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	NME7 INTS7 USP9X PCM1 SEC13	8.05e-05	475	33	5	31040226
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	DARS1 RNMT BUB3 NAT10 SEC13	9.68e-05	494	33	5	26831064
Pubmed	Insights into the ubiquitin-proteasome system of human embryonic stem cells.	CPSF2 BUB3 PCM1 NAT10	1.20e-04	269	33	4	29511261
Pubmed	Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.	BUB3 INTS7 NAT10	1.33e-04	104	33	3	26167872
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	RUFY2 SESN3 ZC3H14 BRD8 UBASH3A NAT10 HDAC8	1.38e-04	1242	33	7	30973865
Pubmed	The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.	ZC3H14 RNMT CPSF2 USP9X	1.42e-04	281	33	4	24163370
Pubmed	SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.	DARS1 NIBAN2 TIPRL BUB3 USP9X SEC13	1.57e-04	878	33	6	37223481
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	RUFY2 SESN3 DARS1 UBASH3A GFAP USP9X PCM1	1.70e-04	1285	33	7	35914814
Pubmed	Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing.	ZC3H14 CPSF2 BUB3	1.74e-04	114	33	3	31553912
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	ING5 ZC3H14 BRD8 CPSF2 BUB3 INTS7 NAT10	1.77e-04	1294	33	7	30804502
Pubmed	High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface.	DAPK3 RNMT NME7 SEC13	1.99e-04	307	33	4	37499664
Pubmed	Co-adaptor driven assembly of a CUL3 E3 ligase complex.	USP9X SEC13	1.99e-04	22	33	2	35120648
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	BRD8 NIBAN2 CPSF2 BUB3 NAT10	2.08e-04	582	33	5	20467437
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	ZC3H14 DARS1 NIBAN2 TIPRL PCM1 NAT10	2.20e-04	934	33	6	33916271
Pubmed	SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.	DARS1 TIPRL BUB3 USP9X SEC13	2.52e-04	607	33	5	39147351
Pubmed	WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.	DARS1 CPSF2 BUB3 USP9X NAT10	2.68e-04	615	33	5	31048545
Pubmed	A protein interaction landscape of breast cancer.	DARS1 BUB3 USP9X PCM1 NAT10	3.08e-04	634	33	5	34591612
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	BUB3 NME7 USP9X PCM1 PCLO	3.20e-04	639	33	5	23443559
Pubmed	Human transcription factor protein interaction networks.	DARS1 BRD8 CPSF2 USP9X PCM1 NAT10 SEC13	3.25e-04	1429	33	7	35140242
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	DAPK3 DARS1 GFAP USP9X PCM1 PCLO SEC13	3.28e-04	1431	33	7	37142655
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	ZC3H14 BRD8 RNMT CPSF2 BUB3 NAT10	3.42e-04	1014	33	6	32416067
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	ZC3H14 USP9X PCM1 NAT10 SEC13	3.53e-04	653	33	5	22586326
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	ZC3H14 DARS1 CPSF2 USP9X PCM1 NAT10	3.60e-04	1024	33	6	24711643
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	DAPK3 BUB3 PCM1 NAT10 SEC13	3.71e-04	660	33	5	32780723
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	DAPK3 NIBAN2 TIPRL CPSF2 USP9X NAT10	4.09e-04	1049	33	6	27880917
Pubmed	The endolysosomal adaptor PLEKHM1 is a direct target for both mTOR and MAPK pathways.	LAMTOR1 SEC13	4.53e-04	33	33	2	33452816
Pubmed	Loss of Usp9x disrupts cell adhesion, and components of the Wnt and Notch signaling pathways in neural progenitors.	GFAP USP9X	5.09e-04	35	33	2	28808228
Pubmed	Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.	NME7 USP9X PCM1	5.52e-04	169	33	3	31462741
Pubmed	Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.	RNMT CPSF2 BUB3 PCM1 NAT10	5.61e-04	723	33	5	34133714
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	ZC3H14 DARS1 NIBAN2 BUB3 NAT10	5.64e-04	724	33	5	36232890
Pubmed	Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation.	TIPRL NME7	6.33e-04	39	33	2	19064610
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	ZC3H14 BUB3 INTS7 NAT10 SEC13	6.78e-04	754	33	5	35906200
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	DARS1 BUB3 USP9X	6.96e-04	183	33	3	23956138
Pubmed	Defining the membrane proteome of NK cells.	DARS1 CPSF2 RETSAT USP9X PCM1 NAT10	7.21e-04	1168	33	6	19946888
Pubmed	Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes.	BRD8 NAT10	7.34e-04	42	33	2	35705031
Pubmed	ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.	ING5 BRD8	7.34e-04	42	33	2	16387653
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	BRD8 NIBAN2 CPSF2 BUB3 PCM1	7.63e-04	774	33	5	15302935
Pubmed	Proteome analysis of the HIV-1 Gag interactome.	DARS1 NAT10	8.06e-04	44	33	2	25010285
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	TIPRL NME7 USP9X PCM1	8.13e-04	446	33	4	24255178
Pubmed	The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase.	DAPK3 DARS1 CPSF2 SEC13	8.62e-04	453	33	4	27113764
Interaction	TSC1 interactions	LAMTOR1 GFAP USP9X WNK3 PCM1 PAK5 HDAC8	1.75e-06	366	33	7	int:TSC1
Interaction	MEAF6 interactions	ING5 DAPK3 BRD8 SEC13	2.44e-05	104	33	4	int:MEAF6
Interaction	CEP170P1 interactions	RUFY2 DAPK3 CPSF2 PCM1	3.38e-05	113	33	4	int:CEP170P1
Interaction	ISY1-RAB43 interactions	CPSF2 NME7 UBASH3A	3.51e-05	39	33	3	int:ISY1-RAB43
Interaction	DYNLT3 interactions	ZC3H14 BUB3 SEC13	5.06e-05	44	33	3	int:DYNLT3
Interaction	PCM1 interactions	ING5 DAPK3 NME7 USP9X PCM1 PAK5	6.52e-05	434	33	6	int:PCM1
Interaction	EED interactions	DARS1 NIBAN2 LAMTOR1 CPSF2 BUB3 INTS7 USP9X PCM1 NAT10 HDAC8	6.99e-05	1445	33	10	int:EED
Interaction	EEA1 interactions	RUFY2 LAMTOR1 PCM1 SEC13	1.37e-04	162	33	4	int:EEA1
Interaction	SPDL1 interactions	GFAP USP9X WNK3 PCM1 SEC13	1.50e-04	315	33	5	int:SPDL1
Interaction	CEP170 interactions	RUFY2 DAPK3 NME7 USP9X PCM1	1.57e-04	318	33	5	int:CEP170
Interaction	LZTS2 interactions	LAMTOR1 NME7 UBASH3A GFAP IQCE PAK5	1.61e-04	512	33	6	int:LZTS2
Cytoband	Ensembl 112 genes in cytogenetic band chr1q24	TIPRL NME7	3.91e-03	129	33	2	chr1q24
GeneFamily	X-linked mental retardation\|Angiotensin receptors	USP9X HDAC8	1.71e-03	53	21	2	103
Coexpression	SCHLOSSER_MYC_TARGETS_REPRESSED_BY_SERUM	ZC3H14 DARS1 BUB3 SEC13	4.88e-05	161	33	4	M5075
Coexpression	NAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_UP	ZC3H14 DARS1 ATP9B BUB3 INTS7 USP9X PCM1 IQCE	1.02e-04	1215	33	8	M41122
Coexpression	GSE2770_UNTREATED_VS_IL4_TREATED_ACT_CD4_TCELL_48H_DN	ZC3H14 CPSF2 NME7 SEC13	1.11e-04	199	33	4	M6024
Coexpression	GSE14308_TH1_VS_TH17_UP	ING5 NEB UBASH3A DGAT2	1.13e-04	200	33	4	M3371
Coexpression	GSE10273_HIGH_IL7_VS_HIGH_IL7_AND_IRF4_IN_IRF4_8_NULL_PRE_BCELL_UP	RNMT CPSF2 NME7 INTS7	1.13e-04	200	33	4	M320
Coexpression	GSE20198_UNTREATED_VS_IFNA_TREATED_ACT_CD4_TCELL_DN	ING5 DAPK3 DARS1 PCLO	1.13e-04	200	33	4	M7376
Disease	coagulation factor V measurement	NME7 PAK5	2.28e-04	20	33	2	EFO_0008087
Disease	information processing speed, response to cranial radiation therapy	BRD8 PAK5	1.93e-03	58	33	2	EFO_0004363, EFO_0010950
Disease	Adenocarcinoma of large intestine	DAPK3 PAK5	5.18e-03	96	33	2	C1319315
Disease	platelet component distribution width	ING5 BRD8 DGAT2 IQCE	9.65e-03	755	33	4	EFO_0007984

Protein segments in the cluster

Peptide	Gene	Start	Entry
MFMYDLYQSRHNTED	CPSF2	96	Q9P2I0
TTHYMSEAEAVCDRM	ABCA10	1396	Q8WWZ4
YNSSDHDVYHMAVEM	BRD8	786	Q9H0E9
LAIASSYMYEMDDTE	BUB3	291	O43684
DSEYERRMMSVYNHV	INTS7	741	Q9NVH2
EEMRIAMETYYEEVH	IQCE	246	Q6IPM2
HMREQMDNAVYTFET	NIBAN2	436	Q96TA1
VIMRDYHHDNVVDMY	PAK5	496	Q9P286
MMSEEGFENEESDYH	ATP9B	56	O43861
IMDDFQHAMSDSEAY	PCLO	4421	Q9Y6V0
LVHYYEQTSDMMTDA	PCM1	506	Q15154
MSTFRQEDVEDHYEM	DAPK3	1	O43293
QYEAMASSNMHEAEE	GFAP	241	P14136
EMYSRNMVDYHLIMD	NAT10	826	Q9H0A0
EETSNDMEYEVSMSY	KIF19	136	Q2TAC6
ANYMMNVIEVDSAHY	DTX3L	371	Q8TDB6
MATAMYLEHYLDSIE	ING5	1	Q8WYH8
VCHYSFESYEQADMM	RNMT	286	O43148
ADSQGMEQHEYMDRA	LAMTOR1	71	Q6IAA8
MEQHEYMDRARQYST	LAMTOR1	76	Q6IAA8
VASMEEMATFHTDAY	HDAC8	61	Q9BY41
VVTEYHDMVTEMYSG	NME7	291	Q9Y5B8
TQQDIDLYHTMYMEA	DGAT2	351	Q96PD7
YYDTDMDQAMERYVS	RETSAT	411	Q6NUM9
SHEDMIHDAQMDYYG	SEC13	11	P55735
ATYMESMRLYARDHE	USP9X	621	Q93008
LLSEFYEYHALMMEE	RUFY2	131	Q8WXA3
NYHYHEVMEEIADTM	DARS1	296	P14868
MVYNLTYNTMATHED	SESN3	381	P58005
MNDTRLYHEADKTYM	TIPRL	196	O75663
QDYYDMESMVHADTR	ZC3H14	451	Q6PJT7
ESYQEYMDRCTASMV	UBASH3A	556	P57075
MAPEMYEEHYDESVD	WNK3	316	Q9BYP7
RAMYDYMAADADEVS	NEB	6616	P20929