Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	hemoglobin alpha binding	HBB HBD HBE1 HBG1 HBG2	1.69e-11	5	142	5	GO:0031721
GeneOntologyMolecularFunction	haptoglobin binding	HBB HBD HBE1 HBG1 HBG2	4.15e-09	10	142	5	GO:0031720
GeneOntologyMolecularFunction	hemoglobin binding	HBB HBD HBE1 HBG1 HBG2	7.56e-09	11	142	5	GO:0030492
GeneOntologyMolecularFunction	oxygen carrier activity	HBB HBD HBE1 HBG1 HBG2	3.22e-08	14	142	5	GO:0005344
GeneOntologyMolecularFunction	oxygen binding	HBB HBD HBE1 HBG1 HBG2	6.15e-06	37	142	5	GO:0019825
GeneOntologyMolecularFunction	peroxidase activity	DUOX1 HBB HBD HBE1 HBG1 HBG2	6.81e-06	65	142	6	GO:0004601
GeneOntologyMolecularFunction	oxidoreductase activity, acting on peroxide as acceptor	DUOX1 HBB HBD HBE1 HBG1 HBG2	8.13e-06	67	142	6	GO:0016684
GeneOntologyMolecularFunction	molecular carrier activity	RANBP17 CSE1L HBB HBD HBE1 HBG1 HBG2	1.22e-05	108	142	7	GO:0140104
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	ATP5MGL CACNA2D1 GRIK4 GRIK5 NDUFB4 PTK2B SLC6A13 KCNC1 SCNN1A KCNQ2 KCNQ3 SLC23A1 ATP2B4 CNGA3 SLC4A9	4.15e-05	627	142	15	GO:0022890
GeneOntologyMolecularFunction	hemoglobin beta binding	HBB HBD	5.02e-05	2	142	2	GO:0031722
GeneOntologyMolecularFunction	antioxidant activity	DUOX1 HBB HBD HBE1 HBG1 HBG2	6.76e-05	97	142	6	GO:0016209
GeneOntologyMolecularFunction	heme binding	NOX4 DUOX1 HBB HBD HBE1 HBG1 HBG2	1.18e-04	154	142	7	GO:0020037
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	CACNA2D1 GRIK4 GRIK5 SLC6A13 KCNC1 SCNN1A KCNQ2 KCNQ3 SLC23A1 ATP2B4 CNGA3 SLC4A9	1.25e-04	465	142	12	GO:0046873
GeneOntologyMolecularFunction	tetrapyrrole binding	NOX4 DUOX1 HBB HBD HBE1 HBG1 HBG2	1.74e-04	164	142	7	GO:0046906
GeneOntologyMolecularFunction	glutamate-gated receptor activity	GRIK4 GRIK5 PTK2B	2.23e-04	17	142	3	GO:0004970
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	GRIK4 GRIK5 SLC6A13 SCNN1A SLC23A1 CNGA3 SLC4A9	2.25e-04	171	142	7	GO:0015081
GeneOntologyMolecularFunction	ligand-gated sodium channel activity	GRIK4 GRIK5 SCNN1A	2.66e-04	18	142	3	GO:0015280
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	ATP5MGL CACNA2D1 GRIK4 GRIK5 NDUFB4 SLC6A13 KCNC1 SCNN1A KCNQ2 KCNQ3 SLC23A1 ATP2B4 CNGA3 SLC4A9	2.81e-04	664	142	14	GO:0008324
GeneOntologyMolecularFunction	beta-adrenergic receptor kinase activity	GRK2 GRK3	2.98e-04	4	142	2	GO:0047696
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	ATP5MGL CACNA2D1 GRIK4 GRIK5 NDUFB4 PTK2B SLC6A13 KCNC1 SCNN1A KCNQ2 KCNQ3 SLC23A1 ATP2B4 CNGA3 SLC4A9	3.33e-04	758	142	15	GO:0015318
GeneOntologyMolecularFunction	NADPH oxidase H202-forming activity	NOX4 DUOX1	4.95e-04	5	142	2	GO:0106294
GeneOntologyMolecularFunction	sodium channel activity	GRIK4 GRIK5 SCNN1A CNGA3	5.09e-04	52	142	4	GO:0005272
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	ATP5MGL CACNA2D1 GRIK4 GRIK5 NDUFB4 PTK2B SLC6A13 KCNC1 SCNN1A KCNQ2 KCNQ3 SLC23A1 ATP2B4 CNGA3 SLC4A9	5.34e-04	793	142	15	GO:0015075
GeneOntologyMolecularFunction	gated channel activity	CACNA2D1 GRIK4 GRIK5 PTK2B KCNC1 SCNN1A KCNQ2 KCNQ3 CNGA3	6.56e-04	334	142	9	GO:0022836
GeneOntologyMolecularFunction	kainate selective glutamate receptor activity	GRIK4 GRIK5	7.39e-04	6	142	2	GO:0015277
GeneOntologyMolecularFunction	monoatomic cation channel activity	ATP5MGL CACNA2D1 GRIK4 GRIK5 KCNC1 SCNN1A KCNQ2 KCNQ3 CNGA3	7.92e-04	343	142	9	GO:0005261
GeneOntologyMolecularFunction	glutamate receptor activity	GRIK4 GRIK5 PTK2B	9.09e-04	27	142	3	GO:0008066
GeneOntologyMolecularFunction	G protein-coupled receptor kinase activity	GRK2 GRK3	1.03e-03	7	142	2	GO:0004703
GeneOntologyMolecularFunction	channel activity	ATP5MGL CACNA2D1 GRIK4 GRIK5 GJA9 PTK2B KCNC1 SCNN1A KCNQ2 KCNQ3 CNGA3	1.35e-03	525	142	11	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	ATP5MGL CACNA2D1 GRIK4 GRIK5 GJA9 PTK2B KCNC1 SCNN1A KCNQ2 KCNQ3 CNGA3	1.37e-03	526	142	11	GO:0022803
GeneOntologyMolecularFunction	ligase activity	ATP5MGL EARS2 MARS1 IARS1 MCCC2 TTLL12	1.55e-03	174	142	6	GO:0016874
GeneOntologyMolecularFunction	monoatomic ion channel activity	ATP5MGL CACNA2D1 GRIK4 GRIK5 PTK2B KCNC1 SCNN1A KCNQ2 KCNQ3 CNGA3	1.67e-03	459	142	10	GO:0005216
GeneOntologyMolecularFunction	transmembrane transporter activity	ATP5MGL CACNA2D1 GRIK4 GRIK5 NDUFB4 ABCA7 GJA9 PTK2B SLC6A13 KCNC1 SLC22A5 SCNN1A KCNQ2 KCNQ3 SLC23A1 ATP2B4 CNGA3 SLC4A9	1.80e-03	1180	142	18	GO:0022857
GeneOntologyMolecularFunction	transporter activity	ATP5MGL CACNA2D1 GRIK4 GRIK5 NDUFB4 ABCA7 GJA9 PTK2B SLC6A13 CLPTM1L KCNC1 SLC22A5 SCNN1A KCNQ2 KCNQ3 SLC23A1 ATP2B4 CNGA3 SLC4A9	1.98e-03	1289	142	19	GO:0005215
GeneOntologyMolecularFunction	potassium channel activity	GRIK4 GRIK5 KCNC1 KCNQ2 KCNQ3	2.23e-03	128	142	5	GO:0005267
GeneOntologyMolecularFunction	organic acid binding	GPR31 UGT1A6 HBB HBD HBE1 HBG1 HBG2	2.30e-03	254	142	7	GO:0043177
GeneOntologyMolecularFunction	catalytic activity, acting on RNA	BRIP1 EARS2 MARS1 IARS1 PIWIL1 DHX8 TYW1 TGS1 TRMT12	3.02e-03	417	142	9	GO:0140098
GeneOntologyMolecularFunction	nuclear export signal receptor activity	RANBP17 CSE1L	3.16e-03	12	142	2	GO:0005049
GeneOntologyMolecularFunction	NAD(P)H oxidase H2O2-forming activity	NOX4 DUOX1	3.16e-03	12	142	2	GO:0016174
GeneOntologyMolecularFunction	superoxide-generating NAD(P)H oxidase activity	NOX4 DUOX1	3.16e-03	12	142	2	GO:0016175
GeneOntologyMolecularFunction	ligase activity, forming carbon-oxygen bonds	EARS2 MARS1 IARS1	3.30e-03	42	142	3	GO:0016875
GeneOntologyMolecularFunction	aminoacyl-tRNA ligase activity	EARS2 MARS1 IARS1	3.30e-03	42	142	3	GO:0004812
GeneOntologyMolecularFunction	catalytic activity, acting on a tRNA	EARS2 MARS1 IARS1 TYW1 TRMT12	3.70e-03	144	142	5	GO:0140101
GeneOntologyMolecularFunction	RNA polymerase III general transcription initiation factor activity	GTF3C3 SNAPC1	3.72e-03	13	142	2	GO:0000995
GeneOntologyBiologicalProcess	oxygen transport	HBB HBD HBE1 HBG1 HBG2	3.81e-08	15	140	5	GO:0015671
GeneOntologyBiologicalProcess	hydrogen peroxide catabolic process	DUOX1 HBB HBD HBE1 HBG1 HBG2	8.36e-08	33	140	6	GO:0042744
GeneOntologyBiologicalProcess	carbon dioxide transport	HBB HBD HBE1 HBG1 HBG2	1.44e-07	19	140	5	GO:0015670
GeneOntologyBiologicalProcess	hydrogen peroxide metabolic process	NOX4 DUOX1 HBB HBD HBE1 HBG1 HBG2	3.53e-07	67	140	7	GO:0042743
GeneOntologyBiologicalProcess	gas transport	HBB HBD HBE1 HBG1 HBG2	7.86e-07	26	140	5	GO:0015669
GeneOntologyBiologicalProcess	one-carbon compound transport	HBB HBD HBE1 HBG1 HBG2	2.73e-06	33	140	5	GO:0019755
GeneOntologyBiologicalProcess	response to toxic substance	BRIP1 PON3 DUOX1 KCNC1 SLC22A5 HBB HBD HBE1 HBG1 HBG2 SLC23A1	4.63e-06	289	140	11	GO:0009636
GeneOntologyBiologicalProcess	reactive oxygen species metabolic process	NAGLU PON3 NOX4 PTK2B DUOX1 HBB HBD HBE1 HBG1 HBG2	3.06e-05	291	140	10	GO:0072593
GeneOntologyBiologicalProcess	cellular oxidant detoxification	DUOX1 HBB HBD HBE1 HBG1 HBG2	6.20e-05	100	140	6	GO:0098869
GeneOntologyBiologicalProcess	sodium ion transport	PON3 SLC6A13 SLC22A5 SCNN1A KCNQ2 SLC23A1 ATP2B4 CNGA3 SLC4A9	1.12e-04	275	140	9	GO:0006814
GeneOntologyBiologicalProcess	regulation of action potential firing threshold	KCNQ2 KCNQ3	1.37e-04	3	140	2	GO:0099611
GeneOntologyBiologicalProcess	substantia propria of cornea development	KCNQ2 KCNQ3	1.37e-04	3	140	2	GO:1903701
GeneOntologyBiologicalProcess	apoptosome assembly	KCNQ2 KCNQ3	1.37e-04	3	140	2	GO:0097314
GeneOntologyBiologicalProcess	detoxification	DUOX1 SLC22A5 HBB HBD HBE1 HBG1 HBG2	1.64e-04	170	140	7	GO:0098754
GeneOntologyBiologicalProcess	membrane lipid metabolic process	GPLD1 SPTLC2 NAGLU HACD2 SGMS1 AGK ST8SIA5 PIGM	1.74e-04	229	140	8	GO:0006643
GeneOntologyBiologicalProcess	polyol metabolic process	SPTLC2 PTAFR COQ3 GALR2 GRK3 DGAT2	1.95e-04	123	140	6	GO:0019751
GeneOntologyBiologicalProcess	cellular detoxification	DUOX1 HBB HBD HBE1 HBG1 HBG2	2.32e-04	127	140	6	GO:1990748
GeneOntologyBiologicalProcess	regulation of eIF2 alpha phosphorylation by heme	HBB HBD	2.72e-04	4	140	2	GO:0010999
GeneOntologyBiologicalProcess	cellular catabolic process	GPLD1 SPTLC2 NAGLU PHB2 PON3 TBC1D25 MCCC2 ADTRP PNKD PNPLA5 ABCA7 SNX14 DUOX1 SMO HBB HBD HBE1 HBG1 HBG2 ATP2B4	3.10e-04	1253	140	20	GO:0044248
GeneOntologyCellularComponent	haptoglobin-hemoglobin complex	HBB HBD HBE1 HBG1 HBG2	9.56e-09	12	140	5	GO:0031838
GeneOntologyCellularComponent	hemoglobin complex	HBB HBD HBE1 HBG1 HBG2	9.56e-09	12	140	5	GO:0005833
GeneOntologyCellularComponent	cation channel complex	ATP5MGL CACNA2D1 GRIK4 GRIK5 KCNC1 SCNN1A KCNQ2 KCNQ3 CNGA3	3.01e-05	235	140	9	GO:0034703
GeneOntologyCellularComponent	monoatomic ion channel complex	ATP5MGL CACNA2D1 GRIK4 GRIK5 PTK2B KCNC1 SCNN1A KCNQ2 KCNQ3 CNGA3	2.37e-04	378	140	10	GO:0034702
GeneOntologyCellularComponent	kainate selective glutamate receptor complex	GRIK4 GRIK5	6.56e-04	6	140	2	GO:0032983
GeneOntologyCellularComponent	potassium channel complex	GRIK4 GRIK5 KCNC1 KCNQ2 KCNQ3	6.78e-04	104	140	5	GO:0034705
GeneOntologyCellularComponent	transmembrane transporter complex	ATP5MGL CACNA2D1 GRIK4 GRIK5 NDUFB4 PTK2B KCNC1 SCNN1A KCNQ2 KCNQ3 CNGA3	8.06e-04	523	140	11	GO:1902495
GeneOntologyCellularComponent	sodium channel complex	GRIK4 GRIK5 SCNN1A	9.46e-04	29	140	3	GO:0034706
GeneOntologyCellularComponent	axon initial segment	KCNQ2 KCNQ3 CNGA3	9.46e-04	29	140	3	GO:0043194
GeneOntologyCellularComponent	endoplasmic reticulum membrane	MBOAT7 SPTLC2 UGT1A6 OR9Q2 PON3 NOX4 HACD2 DCSTAMP GGCX TMX2 NBAS KSR1 CLPTM1L SGMS1 DGAT2 CNIH4 TMEM97 LNPK PIGM	1.02e-03	1293	140	19	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	MBOAT7 SPTLC2 UGT1A6 OR9Q2 PON3 NOX4 HACD2 DCSTAMP GGCX TMX2 NBAS KSR1 CLPTM1L SGMS1 DGAT2 CNIH4 TMEM97 LNPK PIGM	1.08e-03	1299	140	19	GO:0098827
GeneOntologyCellularComponent	transporter complex	ATP5MGL CACNA2D1 GRIK4 GRIK5 NDUFB4 PTK2B KCNC1 SCNN1A KCNQ2 KCNQ3 CNGA3	1.21e-03	550	140	11	GO:1990351
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	MBOAT7 SPTLC2 UGT1A6 OR9Q2 PON3 NOX4 HACD2 DCSTAMP GGCX TMX2 NBAS KSR1 CLPTM1L SGMS1 DGAT2 CNIH4 TMEM97 LNPK PIGM	1.39e-03	1327	140	19	GO:0042175
HumanPheno	Increased red cell sickling tendency	HBB HBG1 HBG2	9.33e-06	5	51	3	HP:0008346
HumanPheno	HbS hemoglobin	HBB HBG1 HBG2	9.33e-06	5	51	3	HP:0045047
HumanPheno	Splenic infarction	HBB HBG1 HBG2	3.22e-05	7	51	3	HP:0034336
Domain	Haemoglobin_b	HBB HBD HBE1 HBG1 HBG2	2.28e-11	5	141	5	IPR002337
Domain	Globin	HBB HBD HBE1 HBG1 HBG2	1.73e-08	12	141	5	IPR000971
Domain	Globin	HBB HBD HBE1 HBG1 HBG2	1.73e-08	12	141	5	PF00042
Domain	GLOBIN	HBB HBD HBE1 HBG1 HBG2	1.73e-08	12	141	5	PS01033
Domain	-	HBB HBD HBE1 HBG1 HBG2	2.80e-08	13	141	5	1.10.490.10
Domain	Globin/Proto	HBB HBD HBE1 HBG1 HBG2	2.80e-08	13	141	5	IPR012292
Domain	Globin-like	HBB HBD HBE1 HBG1 HBG2	9.33e-08	16	141	5	IPR009050
Domain	KCNQC3-Ank-G_bd	KCNQ2 KCNQ3	5.66e-05	2	141	2	PF11956
Domain	CLPTM1	CLPTM1L CLPTM1	5.66e-05	2	141	2	IPR008429
Domain	CLPTM1	CLPTM1L CLPTM1	5.66e-05	2	141	2	PF05602
Domain	Clathrin_b-adaptin_app_Ig-like	AP1B1 AP2B1	5.66e-05	2	141	2	IPR013037
Domain	-	AP1B1 AP2B1	5.66e-05	2	141	2	2.60.40.1150
Domain	Ankyrin-G_BS	KCNQ2 KCNQ3	5.66e-05	2	141	2	IPR020969
Domain	AP_complex_bsu_1_2_4	AP1B1 AP2B1	1.69e-04	3	141	2	IPR016342
Domain	B2-adapt-app_C	AP1B1 AP2B1	1.69e-04	3	141	2	PF09066
Domain	Rossmann-like_a/b/a_fold	EARS2 MARS1 IARS1 FLAD1	3.06e-04	43	141	4	IPR014729
Domain	-	EARS2 MARS1 IARS1 FLAD1	3.06e-04	43	141	4	3.40.50.620
Domain	aa-tRNA-synth_I_CS	EARS2 MARS1 IARS1	3.16e-04	18	141	3	IPR001412
Domain	B2-adapt-app_C	AP1B1 AP2B1	3.36e-04	4	141	2	SM01020
Domain	B-adaptin_app_sub_C	AP1B1 AP2B1	3.36e-04	4	141	2	IPR015151
Domain	AA_TRNA_LIGASE_I	EARS2 MARS1 IARS1	3.74e-04	19	141	3	PS00178
Domain	AP_beta	AP1B1 AP2B1	5.58e-04	5	141	2	IPR026739
Domain	K_chnl_volt-dep_KCNQ_C	KCNQ2 KCNQ3	5.58e-04	5	141	2	IPR013821
Domain	K_chnl_volt-dep_KCNQ	KCNQ2 KCNQ3	5.58e-04	5	141	2	IPR003937
Domain	KCNQ_channel	KCNQ2 KCNQ3	5.58e-04	5	141	2	PF03520
Domain	Beta2_adaptin/TBP_C_dom	AP1B1 AP2B1	8.32e-04	6	141	2	IPR012295
Domain	-	AP1B1 AP2B1	8.32e-04	6	141	2	3.30.310.10
Domain	GPCR_kinase	GRK2 GRK3	1.16e-03	7	141	2	IPR000239
Domain	NAD_binding_6	NOX4 DUOX1	1.16e-03	7	141	2	PF08030
Domain	FAD_binding_8	NOX4 DUOX1	1.16e-03	7	141	2	PF08022
Domain	FAD-bd_8	NOX4 DUOX1	1.16e-03	7	141	2	IPR013112
Domain	Fe_red_NAD-bd_6	NOX4 DUOX1	1.16e-03	7	141	2	IPR013121
Domain	Coatomer/calthrin_app_sub_C	AP1B1 AP2B1	1.54e-03	8	141	2	IPR009028
Domain	VG_K_chnl	KCNC1 KCNQ2 KCNQ3	1.95e-03	33	141	3	IPR028325
Domain	Alpha_adaptinC2	AP1B1 AP2B1	1.97e-03	9	141	2	PF02883
Domain	Clathrin_a/b/g-adaptin_app_Ig	AP1B1 AP2B1	1.97e-03	9	141	2	IPR008152
Domain	Alpha_adaptinC2	AP1B1 AP2B1	1.97e-03	9	141	2	SM00809
Domain	RGS	SNX14 GRK2 GRK3	2.31e-03	35	141	3	PF00615
Domain	RGS	SNX14 GRK2 GRK3	2.31e-03	35	141	3	SM00315
Domain	RGS	SNX14 GRK2 GRK3	2.51e-03	36	141	3	PS50132
Domain	-	MARS1 IARS1	2.98e-03	11	141	2	1.10.730.10
Domain	RGS	SNX14 GRK2 GRK3	3.16e-03	39	141	3	IPR016137
Domain	Ferric_reduct	NOX4 DUOX1	3.55e-03	12	141	2	PF01794
Domain	Coatomer/clathrin_app_Ig-like	AP1B1 AP2B1	3.55e-03	12	141	2	IPR013041
Domain	Fe3_Rdtase_TM_dom	NOX4 DUOX1	3.55e-03	12	141	2	IPR013130
Domain	Clathrin/coatomer_adapt-like_N	AP1B1 AP2B1	5.57e-03	15	141	2	IPR002553
Domain	Beta/gamma_crystallin	CRYBG2 CRYGC	5.57e-03	15	141	2	IPR001064
Domain	Adaptin_N	AP1B1 AP2B1	5.57e-03	15	141	2	PF01602
Domain	CRYSTALLIN_BETA_GAMMA	CRYBG2 CRYGC	5.57e-03	15	141	2	PS50915
Domain	IBN_N	RANBP17 CSE1L	5.57e-03	15	141	2	PF03810
Domain	Crystall	CRYBG2 CRYGC	5.57e-03	15	141	2	PF00030
Domain	XTALbg	CRYBG2 CRYGC	5.57e-03	15	141	2	SM00247
Domain	tRNAsynth_Ia_anticodon-bd	MARS1 IARS1	5.57e-03	15	141	2	IPR009080
Domain	TBC	TBC1D25 SGSM2 SGSM3	6.02e-03	49	141	3	SM00164
Domain	IBN_N	RANBP17 CSE1L	6.34e-03	16	141	2	SM00913
Domain	Importin-beta_N	RANBP17 CSE1L	7.15e-03	17	141	2	IPR001494
Domain	RabGAP-TBC	TBC1D25 SGSM2 SGSM3	7.49e-03	53	141	3	PF00566
Pubmed	Extensive movement of LINES ONE sequences in beta-globin loci of Mus caroli and Mus domesticus.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	2905421
Pubmed	An intron nucleotide sequence variant in a cloned beta +-thalassaemia globin gene.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	6264391
Pubmed	A single-base change at a splice site in a beta 0-thalassemic gene causes abnormal RNA splicing.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	7151176
Pubmed	The 3' splice site of pre-messenger RNA is recognized by a small nuclear ribonucleoprotein.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	2933810
Pubmed	Direct sequencing of enzymatically amplified human genomic DNA.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	3267215
Pubmed	A fusion gene in man: DNA sequence analysis of the abnormal globin gene of hemoglobin Miyada.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	6324786
Pubmed	mRNA precursor splicing in vivo: sequence requirements determined by deletion analysis of an intervening sequence.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	3857622
Pubmed	A naturally occurring deletion in the mouse Hbbs beta-globin gene cluster.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	3459181
Pubmed	G to A substitution in the distal CCAAT box of the A gamma-globin gene in Greek hereditary persistence of fetal haemoglobin.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	2578619
Pubmed	A point mutation in the A gamma-globin gene promoter in Greek hereditary persistence of fetal haemoglobin.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	2578620
Pubmed	Duplication followed by deletion accounts for the structure of an Indian deletion beta (0)-thalassemia gene.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	7162987
Pubmed	A weak upstream promoter gives rise to long human beta-globin RNA molecules.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	6303333
Pubmed	Beta + thalassemia: aberrant splicing results from a single point mutation in an intron.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	6895866
Pubmed	Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	7557375
Pubmed	The beta-globin gene in Sardinian delta beta 0-thalassemia carries a C----T nonsense mutation at codon 39.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	6327288
Pubmed	beta-Thalassemia present in cis to a new beta-chain structural variant, Hb Vicksburg [beta 75 (E19)Leu leads to 0].	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	6165992
Pubmed	beta zero thalassemia in Sardinia is caused by a nonsense mutation.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	6457059
Pubmed	mRNA-deficient beta o-thalassemia results from a single nucleotide deletion.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	6292840
Pubmed	Epsilon globin gene transcripts originating upstream of the mRNA cap site in K562 cells and normal human embryos.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	6292831
Pubmed	Unexpected relationships between four large deletions in the human beta-globin gene cluster.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	6652684
Pubmed	Cloning specific complete polyadenylylated 3'-terminal cDNA segments.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	2581851
Pubmed	Human beta-globin messenger RNA. I. Nucleotide sequences derived from complementary RNA.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	873928
Pubmed	beta 0 thalassemia, a nonsense mutation in man.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	88735
Pubmed	Cryptic branch point activation allows accurate in vitro splicing of human beta-globin intron mutants.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	3879973
Pubmed	The "beta-like-globin" gene domain in human erythroid cells.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	3879975
Pubmed	Molecular characterization of seven beta-thalassemia mutations in Asian Indians.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	6714226
Pubmed	Base substitution at position -88 in a beta-thalassemic globin gene. Further evidence for the role of distal promoter element ACACCC.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	6086605
Pubmed	Linkage of beta-thalassaemia mutations and beta-globin gene polymorphisms with DNA polymorphisms in human beta-globin gene cluster.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	6280057
Pubmed	A nucleotide change at a splice junction in the human beta-globin gene is associated with beta 0-thalassemia.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	6270663
Pubmed	Hemoglobin Long Island is caused by a single mutation (adenine to cytosine) resulting in a failure to cleave amino-terminal methionine.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	3455755
Pubmed	Alternative sites of transcription initiation upstream of the canonical cap site in human gamma-globin and beta-globin genes.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	6701091
Pubmed	Human fetal globin DNA sequences suggest novel conversion event.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	6330670
Pubmed	Beta-thalassemia due to a T----A mutation within the ATA box.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	3382401
Pubmed	Developmental regulation of a complete 70-kb human beta-globin locus in transgenic mice.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	1383089
Pubmed	Nucleotide sequence of the BALB/c mouse beta-globin complex.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	2926808
Pubmed	The deletion in a type of delta 0-beta 0-thalassaemia begins in an inverted AluI repeat.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	6184621
Pubmed	The structure and expression of the haemoglobin genes.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	6297279
Pubmed	Nonsense and frameshift mutations in beta 0-thalassemia detected in cloned beta-globin genes.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	6985481
Pubmed	Nonsense mutation as a cause of beta 0 thalassemia.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	6985475
Pubmed	Identification of a retrovirus-like repetitive element in human DNA.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	6095301
Pubmed	A transient definitive erythroid lineage with unique regulation of the β-globin locus in the mammalian embryo.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	21378272
Pubmed	A molecular study of a family with Greek hereditary persistence of fetal hemoglobin and beta-thalassemia.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	6210198
Pubmed	Structure and expression of a cloned beta o thalassaemic globin gene.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	6272205
Pubmed	Transcriptional interference among the murine beta-like globin genes.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	17077320
Pubmed	Molecular cloning and characterization of the human beta-like globin gene cluster.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	6155216
Pubmed	DNA sequence organization of the beta-globin complex in the BALB/c mouse.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	6250710
Pubmed	Multiple origins of transcription in the 4.5 Kb upstream of the epsilon-globin gene.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	6194897
Pubmed	Analysis of mice containing a targeted deletion of beta-globin locus control region 5' hypersensitive site 3.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	8649401
Pubmed	Human beta-globin promoter and coding sequences transcribed by RNA polymerase III.	HBB HBD HBE1 HBG1 HBG2	1.06e-12	5	142	5	6194893
Pubmed	"Maturational" globin switching in primary primitive erythroid cells.	HBB HBD HBE1 HBG1 HBG2	6.32e-12	6	142	5	16263786
Pubmed	Multiple hematopoietic defects and delayed globin switching in Ikaros null mice.	HBB HBD HBE1 HBG1 HBG2	6.32e-12	6	142	5	11805317
Pubmed	The structure and evolution of the human beta-globin gene family.	HBB HBD HBE1 HBG1 HBG2	6.32e-12	6	142	5	6985477
Pubmed	A novel strategy to identify maternal and paternal inheritance in the mouse.	HBB HBD HBE1 HBG1 HBG2	6.32e-12	6	142	5	7588571
Pubmed	ZNF410 represses fetal globin by singular control of CHD4.	HBB HBD HBE1 HBG1 HBG2	2.21e-11	7	142	5	33859416
Pubmed	Immature erythroblasts with extensive ex vivo self-renewal capacity emerge from the early mammalian fetus.	HBB HBD HBE1 HBG1 HBG2	2.21e-11	7	142	5	21127173
Pubmed	Developmental and species-divergent globin switching are driven by BCL11A.	HBB HBD HBE1 HBG1 HBG2	2.21e-11	7	142	5	19657335
Pubmed	Strict in vivo specificity of the Bcl11a erythroid enhancer.	HBB HBD HBE1 HBG1 HBG2	2.21e-11	7	142	5	27707736
Pubmed	Early mammalian erythropoiesis requires the Dot1L methyltransferase.	HBB HBD HBE1 HBG1 HBG2	2.21e-11	7	142	5	20798234
Pubmed	Sox6 directly silences epsilon globin expression in definitive erythropoiesis.	HBB HBD HBE1 HBG1 HBG2	2.21e-11	7	142	5	16462943
Pubmed	Mechanisms of developmental control of transcription in the murine alpha- and beta-globin loci.	HBB HBD HBE1 HBG1 HBG2	2.21e-11	7	142	5	9887104
Pubmed	Cis-regulatory mechanisms governing stem and progenitor cell transitions.	HBB HBD HBE1 HBG1 HBG2	5.86e-11	8	142	5	26601269
Pubmed	UCP2 modulates cell proliferation through the MAPK/ERK pathway during erythropoiesis and has no effect on heme biosynthesis.	HBB HBD HBE1 HBG1 HBG2	5.86e-11	8	142	5	18687678
Pubmed	Real-time PCR for single-cell genotyping in sickle cell and thalassemia syndromes as a rapid, accurate, reliable, and widely applicable protocol for preimplantation genetic diagnosis.	HBB HBD HBE1 HBG1 HBG2	5.86e-11	8	142	5	15108284
Pubmed	Poly(C)-Binding Protein Pcbp2 Enables Differentiation of Definitive Erythropoiesis by Directing Functional Splicing of the Runx1 Transcript.	HBB HBD HBE1 HBG1 HBG2	5.86e-11	8	142	5	29866654
Pubmed	Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene.	HBB HBD HBE1 HBG1 HBG2	1.31e-10	9	142	5	7753194
Pubmed	Peroxidase activity of hemoglobin-haptoglobin complexes: covalent aggregation and oxidative stress in plasma and macrophages.	HBB HBD HBE1 HBG1 HBG2	1.31e-10	9	142	5	19740759
Pubmed	3' non-coding region sequences in eukaryotic messenger RNA.	HBB HBD HBE1 HBG1 HBG2	1.31e-10	9	142	5	822353
Pubmed	Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing.	HBB HBD HBE1 HBG1 HBG2	1.31e-10	9	142	5	23716600
Pubmed	Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion.	HBB HBD HBE1 HBG1 HBG2	1.31e-10	9	142	5	9887098
Pubmed	Role of the GATA-1/FOG-1/NuRD pathway in the expression of human beta-like globin genes.	HBB HBD HBE1 HBG1 HBG2	1.31e-10	9	142	5	20439494
Pubmed	KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic beta-like globin genes in vivo.	HBB HBD HBE1 HBG1 HBG2	2.62e-10	10	142	5	15947087
Pubmed	The mouse globin pseudogene beta h3 is descended from a premammalian delta-globin gene.	HBB HBD HBG1 HBG2	2.66e-10	4	142	4	6092350
Pubmed	Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF.	HBB HBD HBE1 HBG1 HBG2	4.79e-10	11	142	5	7753195
Pubmed	TAF10 Interacts with the GATA1 Transcription Factor and Controls Mouse Erythropoiesis.	HBB HBD HBE1 HBG1 HBG2	8.18e-10	12	142	5	25870109
Pubmed	A review of the molecular genetics of the human alpha-globin gene cluster.	HBB HBD HBE1 HBG1 HBG2	8.18e-10	12	142	5	2649166
Pubmed	Hematopoietic induction and respecification of A-P identity by visceral endoderm signaling in the mouse embryo.	HBB HBD HBE1 HBG1 HBG2	8.18e-10	12	142	5	9811585
Pubmed	Variegated gene expression caused by cell-specific long-range DNA interactions.	HBB HBD HBE1 HBG1 HBG2	8.18e-10	12	142	5	21706023
Pubmed	POGZ Is Required for Silencing Mouse Embryonic β-like Hemoglobin and Human Fetal Hemoglobin Expression.	HBB HBD HBE1 HBG1 HBG2	1.33e-09	13	142	5	29898395
Pubmed	Defective erythropoiesis in transgenic mice expressing dominant-negative upstream stimulatory factor.	HBB HBD HBE1 HBG1 HBG2	1.33e-09	13	142	5	19704006
Pubmed	Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes.	HBB HBD HBE1 HBG1 HBG2	3.07e-09	15	142	5	10220430
Pubmed	Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells.	HBB HBD HBG1 HBG2	3.97e-09	6	142	4	17655922
Pubmed	HIC2 regulates isoform switching during maturation of the cardiovascular system.	HBB HBD HBE1 HBG1 HBG2	4.45e-09	16	142	5	29061339
Pubmed	A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development.	HBB HBD HBE1 HBG1 HBG2	6.29e-09	17	142	5	16287714
Pubmed	EHBP1L1, an apicobasal polarity regulator, is critical for nuclear polarization during enucleation of erythroblasts.	HBB HBD HBE1 HBG1 HBG2	6.29e-09	17	142	5	37042948
Pubmed	Protein phosphatase 2A catalytic subunit α (PP2Acα) maintains survival of committed erythroid cells in fetal liver erythropoiesis through the STAT5 pathway.	HBB HBD HBE1 HBG1 HBG2	1.56e-08	20	142	5	21514445
Pubmed	Targeted deletion of Nm23/nucleoside diphosphate kinase A and B reveals their requirement for definitive erythropoiesis in the mouse embryo.	HBB HBD HBG1 HBG2	1.84e-08	8	142	4	19235734
Pubmed	A genome-wide association identified the common genetic variants influence disease severity in beta0-thalassemia/hemoglobin E.	HBD HBE1 HBG1 HBG2	1.84e-08	8	142	4	20183929
Pubmed	The multiple functions of hemoglobin.	HBB HBD HBE1 HBG1	1.84e-08	8	142	4	7555018
Pubmed	Jak2 is essential for signaling through a variety of cytokine receptors.	HBB HBD HBE1 HBG1 HBG2	2.04e-08	21	142	5	9590173
Pubmed	Novel insights into erythroid development revealed through in vitro differentiation of GATA-1 embryonic stem cells.	HBB HBD HBG1 HBG2	3.30e-08	9	142	4	7926723
Pubmed	A mutant mouse with severe anemia and skin abnormalities controlled by a new allele of the flaky skin (fsn) locus.	HBB HBD HBG1 HBG2	3.30e-08	9	142	4	16093647
Pubmed	Mouse Mix gene is activated early during differentiation of ES and F9 stem cells and induces endoderm in frog embryos.	HBB HBD HBG1 HBG2	3.30e-08	9	142	4	12619131
Pubmed	Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL.	AFP HBE1 HBG1 HBG2	3.30e-08	9	142	4	7830794
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	MBOAT7 SPTLC2 NCBP1 HACD2 COQ3 NDUFB4 TMUB1 KSR1 AP1B1 FLAD1 CLPTM1 CENPI TYW1 TMEM102 HBB ATP2B4	4.59e-08	719	142	16	35337019
Pubmed	Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor.	HBB HBD HBE1 HBG1 HBG2	5.26e-08	25	142	5	20696915
Pubmed	Disruption of palladin leads to defects in definitive erythropoiesis by interfering with erythroblastic island formation in mouse fetal liver.	HBB HBD HBE1 HBG1 HBG2	5.26e-08	25	142	5	17431131
Pubmed	Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse.	HBB HBD HBG1 HBG2	5.49e-08	10	142	4	10529424
Pubmed	SCL interacts with VEGF to suppress apoptosis at the onset of hematopoiesis.	HBB HBD HBG1 HBG2	5.49e-08	10	142	4	14729577
Pubmed	Multilineage hematopoietic progenitor activity generated autonomously in the mouse yolk sac: analysis using angiogenesis-defective embryos.	HBB HBD HBG1 HBG2	5.49e-08	10	142	4	12755332
Pubmed	Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis.	HBB HBD HBE1 HBG1 HBG2	6.49e-08	26	142	5	10943842
Interaction	PCDHGC4 interactions	SPTLC2 TAF6L AREL1 SNX14 TMEM97 TYW1	1.13e-05	73	139	6	int:PCDHGC4
Interaction	CYP19A1 interactions	CACNA2D1 TMX2 FANCG SNX14 TYW1	1.59e-05	46	139	5	int:CYP19A1
Cytoband	11p15.5	HBB HBD HBE1 HBG1 HBG2	3.49e-05	118	142	5	11p15.5
GeneFamily	Hemoglobin subunits	HBB HBD HBE1 HBG1 HBG2	7.98e-10	10	93	5	940
GeneFamily	Small G protein signaling modulators	SGSM2 SGSM3	7.83e-05	3	93	2	751
GeneFamily	Aminoacyl tRNA synthetases, Class I	EARS2 MARS1 IARS1	1.20e-04	19	93	3	131
GeneFamily	Glutamate ionotropic receptor kainate type subunits	GRIK4 GRIK5	2.59e-04	5	93	2	1199
GeneFamily	Potassium voltage-gated channels	KCNC1 KCNQ2 KCNQ3	1.13e-03	40	93	3	274
Coexpression	HEVNER_TELENCEPHALON_ERYTHROCYTES	HBE1 HBG1 HBG2	8.55e-06	8	142	3	MM389
Coexpression	GSE3994_WT_VS_PAC1_KO_ACTIVATED_MAST_CELL_DN	CYSLTR2 KLHDC2 GTF3C3 JAK3 PTK2B AP1B1 KBTBD11 SMO	1.40e-05	200	142	8	M6372
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#3_top-relative-expression-ranked_200	AFP HBE1 HBG2	5.77e-06	6	142	3	gudmap_developingLowerUrinaryTract_e14.5_ urethra_200_k3
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#1_top-relative-expression-ranked_200	AFP HBE1 HBG2	1.60e-05	8	142	3	gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_200_k1
CoexpressionAtlas	DevelopingKidney_e12.5_renal vesicle_emap-27679_k-means-cluster#2_top-relative-expression-ranked_100	HBE1 HBG2	4.44e-05	2	142	2	gudmap_developingKidney_e12.5_renal vesicle_100_k2
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#3_top-relative-expression-ranked_500	AFP HBE1 HBG2	7.97e-05	13	142	3	gudmap_developingLowerUrinaryTract_e14.5_ urethra_500_k3
ToppCell	droplet-Bladder-BLADDER-1m-Epithelial-luminal_bladder_epithelial_cell_(umbrella_cell)\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TSPAN12 PON3 MCCC2 HACD2 ADTRP FAT2 KBTBD11 CNGA3	1.49e-07	184	143	8	382b1e90b3f437af596750669c0465a169d97095
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SPTLC2 PPM1E ADTRP DMRT2 SCNN1A ST8SIA5 SLC4A9	1.54e-06	174	143	7	5f4436863a40f8bca46e2989bca66c02b6be88d4
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SPTLC2 PPM1E ADTRP DMRT2 B4GALNT2 ST8SIA5 SLC4A9	1.66e-06	176	143	7	25ebc8716aa44e44fce577701e3e82c6745a75ab
ToppCell	PCW_10-12-Hematologic_ErythroMegGranulo\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	HBD SLA TMEM71 PTK2B HBB HBG1 HBG2	2.57e-06	188	143	7	adf9011ba8e3c6418fb68bf5c44b2e3b0ec7dafe
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA2D1 GRIK5 PTK2B KCNC1 SGSM2 KCNQ2 ATP2B4	3.06e-06	193	143	7	be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA2D1 GRIK5 PTK2B KCNC1 SGSM2 KCNQ2 ATP2B4	3.06e-06	193	143	7	0c652ebe22ce5d2927599dd97ef1920547858395
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA2D1 GRIK5 PTK2B KCNC1 SGSM2 KCNQ2 ATP2B4	3.06e-06	193	143	7	8689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCell	severe-Myeloid-Neutrophils_4\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	MBOAT7 HBD JAK3 DGAT2 HBB HBG1 HBG2	3.75e-06	199	143	7	50242666def13e5d4149c563ae000d6768f086f7
ToppCell	control-Myeloid-Neutrophils_4\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	MBOAT7 HBD DGAT2 HBB HBG1 HBG2	1.02e-05	153	143	6	87dc61f7dd76b42c4d1e14fd33958b6a02116bc8
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Myeloid\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTAFR ADTRP SLC6A13 DGAT2 SCNN1A MMP8	1.18e-05	157	143	6	320d5ac063fd90e26f537475c328b3ae73974bc1
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Myeloid-mast_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTAFR ADTRP SLC6A13 DGAT2 SCNN1A MMP8	1.18e-05	157	143	6	e4b17c267b754c5af95cdf17f629354d1a8a8ad7
ToppCell	10x3'2.3-week_12-13-Hematopoietic-erythroid-late_erythroid\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	HBB HBD HBE1 HBG1 HBG2	1.19e-05	92	143	5	3292898c81580e33c82f91b949a86bf4b5297781
ToppCell	IIF\|World / Disease, Lineage and Cell Type	TSPYL2 HBD HBB HBE1 HBG1 HBG2	1.79e-05	169	143	6	ebf726f725079317ad67c2f754748b4112607277
ToppCell	368C-Myeloid-Macrophage-FABP4+_Macrophage_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	IARS1 NAGLU CNIH4 AFP CENPI AGK	1.92e-05	171	143	6	e59afa0a773dca3b9c208d17510ea55703b42598
ToppCell	PCW_13-14-Hematologic_ErythroMegGranulo-Hem_ErythroMeg\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	HBD CMTM5 HBB HBE1 HBG1 HBG2	2.18e-05	175	143	6	c33317d8d60ea88ec326daf91dfd3416a62f9938
ToppCell	CV-Severe-7\|Severe / Virus stimulation, Condition and Cluster	HACD2 NBAS URB1 CSE1L GLG1 PISD	2.33e-05	177	143	6	82fdd6185b368f54f03de389427cbe3071d21a99
ToppCell	COVID-19-Epithelial_cells-AT1\|COVID-19 / group, cell type (main and fine annotations)	LAMC2 RANBP17 DUOX1 SCNN1A NAV2 KCNQ3	2.48e-05	179	143	6	a0b33bd69ffdfd5d38d80207fb40058a490aa19e
ToppCell	wk_20-22-Hematologic-Meg-ery\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	CMTM5 HBB HBD HBE1 HBG1 HBG2	2.64e-05	181	143	6	d0637f9ccec5dba4997520b27287989522e04f96
ToppCell	droplet-Kidney-nan-21m-Epithelial-Epcam____kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM151B LAMC2 SCNN1A ST8SIA5 ATP2B4 SLC4A9	2.72e-05	182	143	6	fe4fb213dc0ca482b0f94097fe1b0a51fc2690e2
ToppCell	COVID-19-lung-AT1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	LAMC2 RANBP17 DUOX1 SCNN1A NAV2 KCNQ3	2.81e-05	183	143	6	7b1a385ed54f93bfe85bf0c162e42d05d516b45c
ToppCell	COVID-19-Epithelial_cells-ECM-high_epithelial\|COVID-19 / group, cell type (main and fine annotations)	LAMC2 RANBP17 SCNN1A NAV2 KCNQ3 HBB	2.81e-05	183	143	6	dc1d380bf7564f290256cb7108063d1bd2da732b
ToppCell	COVID-19-lung-AT1\|lung / Disease (COVID-19 only), tissue and cell type	LAMC2 RANBP17 DUOX1 SCNN1A NAV2 KCNQ3	2.81e-05	183	143	6	942530449e9c6583705eeb8f6f12621daea57252
ToppCell	PCW_07-8.5-Neuronal-Neuronal_SCP-neuro_proliferating_SCP2_(1)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	PPM1E TMEM71 FOXD3 KCNQ3 CMTM5 ST8SIA5	2.81e-05	183	143	6	e0854864d377e158a4793088d1cb6b3dbf2c805d
ToppCell	Frontal_cortex-Neuronal-Excitatory\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	CACNA2D1 TEKT5 GALNT16 PTK2B PTPRH ATP2B4	2.90e-05	184	143	6	6e17c8151d6dc543de16d804db956c63c3fda414
ToppCell	PCW_07-8.5-Hematologic_ErythroMegGranulo-Hem_ErythroMeg\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	HBD PTK2B HBB HBE1 HBG1 HBG2	3.08e-05	186	143	6	3b60a153e6cfc1b977a1f8b8f3bcaf75d1f4ff5b
ToppCell	PCW_10-12-Hematologic_ErythroMegGranulo-Hem_ErythroMeg\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	HBD CMTM5 HBB HBE1 HBG1 HBG2	3.08e-05	186	143	6	1c39ced3b32dba2832991284720b6c5f508a2e73
ToppCell	PCW_07-8.5-Hematologic_ErythroMegGranulo\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	HBD PTK2B HBB HBE1 HBG1 HBG2	3.08e-05	186	143	6	294839944266407c40ef86e1d3e0fce4652b70ff
ToppCell	PCW_07-8.5-Hematologic_ErythroMegGranulo-Hem_ErythroMeg-erythro\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	HBD PTK2B HBB HBE1 HBG1 HBG2	3.08e-05	186	143	6	6078aa16261554c7fd41137b8de1362d15b30490
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIK5 PTK2B KCNC1 SGSM2 KCNQ2 ATP2B4	3.08e-05	186	143	6	7278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCell	IIF-Other\|IIF / Disease, Lineage and Cell Type	HBD CMTM5 HBB HBE1 HBG1 HBG2	3.17e-05	187	143	6	ae44d9261698cc0289750a546baf050f78b119b3
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIK4 PTK2B FOXD3 SRPX2 SGSM2 KCNQ2	3.17e-05	187	143	6	e04a84989d624378141042768383b9c846901f2d
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIK4 PTK2B FOXD3 SRPX2 SGSM2 KCNQ2	3.17e-05	187	143	6	24cc03c748e15f7ef0e6509ca5a6ca583fb9c573
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIK4 PTK2B FOXD3 SRPX2 SGSM2 KCNQ2	3.17e-05	187	143	6	2f153b203fe79f206319603cf94d3a03ab49a05d
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PPM1E ADTRP DMRT2 SCNN1A ST8SIA5 SLC4A9	3.27e-05	188	143	6	e751cff2ac8fbc1487766c1871fcc5d1005286b0
ToppCell	Control-B_naive-4\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	LRP1B TEX38 SCNN1A CMTM5 TYW1	3.65e-05	116	143	5	35d471c8dbf408d0be3837c428d9c2a73c805a6f
ToppCell	10x3'2.3-week_12-13-Hematopoietic\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	CMTM5 HBB HBD HBE1 HBG1 HBG2	4.12e-05	196	143	6	05b437af66cb43ba098ea93a02dc2f7430bf8c1b
ToppCell	COVID-19_Severe\|World / Disease group, lineage and cell class	HBD JAK3 CMTM5 MMP8 HBB HBG2	4.24e-05	197	143	6	f0824f98269bdcd8463873beaf222df8f0caa468
ToppCell	PBMC-Severe\|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)	HBD JAK3 CMTM5 MMP8 HBB HBG2	4.24e-05	197	143	6	af10b5e6e959e2ced01ad066f906941bc4194cc3
ToppCell	PBMC-Severe\|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HBD JAK3 CMTM5 MMP8 HBB HBG2	4.24e-05	197	143	6	3ff23b86d310ace388d2efb3ee73dd47c46f363e
ToppCell	COVID-19-COVID-19_Severe\|COVID-19 / Disease, condition lineage and cell class	HBD JAK3 CMTM5 MMP8 HBB HBG2	4.61e-05	200	143	6	3ec89071f002bb66d46146bf4804f91e6f09a36f
ToppCell	MS-IIF\|MS / Disease, condition lineage and cell class	TSPYL2 HBD HBB HBE1 HBG1 HBG2	4.61e-05	200	143	6	221f59edcfc18baece13184c2552d26022228146
ToppCell	MS-Multiple_Sclerosis-Others\|Multiple_Sclerosis / Disease, condition lineage and cell class	HBD CMTM5 HBB HBE1 HBG1 HBG2	4.61e-05	200	143	6	3aa674db6c3e999d8175dd1e9349c18d15ec4e9b
ToppCell	MS-IIF-Others\|IIF / Disease, condition lineage and cell class	HBD CMTM5 HBB HBE1 HBG1 HBG2	4.61e-05	200	143	6	e585ac220594f860f2fa7036bb23b165e2d74a41
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_EM-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ADTRP HBB HBD HBE1 HBG1	7.26e-05	134	143	5	705987fe2abc5ca86abee899755d5ed556ac71ba
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mast-Mast-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	HBB HBD HBE1 HBG1 HBG2	7.79e-05	136	143	5	94eb78a4b8da307c07c2c4f05b8a14424f887579
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Bcl6-Excitatory_Neuron.Slc17a7.Bcl6-Cbln1_(Layer_5a,_entorhinal_cortex_,_Cbln1+)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	DCSTAMP SCNN1A TMEM102 CNGA3	9.47e-05	74	143	4	0be24b07a2503a16ece1489e765200be4c7253cc
ToppCell	Megakaryocytic-erythropoietic-Erythro-cells-Erythrocyte\|Erythro-cells / Lineage, cell class and subclass	HBD HBB HBE1 HBG1 HBG2	1.02e-04	144	143	5	7fbedc65314cfb06bcc527d794b5de7858f7c5ec
ToppCell	mild-Myeloid-Neutrophils_4\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	HBD HBB HBG1 HBG2 SLC23A1	1.24e-04	150	143	5	979566663d1110475f1e017c2f9890aca4b6f701
ToppCell	facs-Liver-Hepatocytes\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPLD1 ADTRP SLC6A13 DGAT2 SLC23A1	1.48e-04	156	143	5	e2cda3ad4e5f44a80133864c5a38b766afb952ce
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3-4_RORB_FOLH1B\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HBD DCSTAMP HBB HBE1 HBG2	1.53e-04	157	143	5	1dbf7c26a2c253835b0cfeb1769f8b5e342f20f5
ToppCell	368C-Myeloid-Macrophage-FABP4+_Macrophage_2\|368C / Donor, Lineage, Cell class and subclass (all cells)	NAGLU ADTRP CNIH4 AFP CENPI	1.67e-04	160	143	5	ac3f56f8ab8efd11c4b4868a828db05c23ac762f
ToppCell	VE-CD8-CD4_Treg\|VE / Condition, Cell_class and T cell subcluster	ATP5MGL ABCA7 ERCC8 DUOX1 KCNC1	1.72e-04	161	143	5	a114f4f75859d9ef900e5146686438d051241429
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	UGT1A6 PIWIL1 AREL1 NAV2 SMO	1.72e-04	161	143	5	0d863d7d369391dd6148e1de6d6f8033dcb8fe0f
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYLD CYSLTR2 TEKT5 TTLL12 KBTBD11	1.82e-04	163	143	5	4af92b211d12c5b88b65bb746242cd702b545bd0
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-CD4+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYLD CYSLTR2 TEKT5 TTLL12 KBTBD11	1.82e-04	163	143	5	d24774e0aa612322c22fdb3b314aef275fa01d68
ToppCell	343B-Epithelial_cells-Epithelial-A_(AT2)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	CLPTM1L DUOX1 FAT2 SCNN1A TMEM97	1.87e-04	164	143	5	beaa13a75c3bb72446c85084d75e9fe3f15fd3d4
ToppCell	343B-Epithelial_cells-Epithelial-A_(AT2)\|343B / Donor, Lineage, Cell class and subclass (all cells)	CLPTM1L DUOX1 FAT2 SCNN1A TMEM97	1.87e-04	164	143	5	d005cfd821b87548b075120bffe65a0be9860463
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BRIP1 COQ3 FANCG GPR137C CENPI	1.93e-04	165	143	5	88681101d7cf60b99b8ace5d8c0944323b937306
ToppCell	TCGA-Colorectal-Solid_Tissue_Normal-Colon_normal_tissue-Colon_normal_tissue-9\|TCGA-Colorectal / Sample_Type by Project: Shred V9	GRIK5 GALNT16 FOXD3 CMTM5 CNGA3	1.98e-04	166	143	5	68e6fc7c0040bbe48a93f96ecf28afffdc626845
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-8\|TCGA-Thryoid / Sample_Type by Project: Shred V9	CYSLTR2 ADTRP PTK2B FUT11 NAV2	2.10e-04	168	143	5	00646601548b0fee42ae16bfa5e93603bc7c5129
ToppCell	5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NOX4 FOXD3 DUOX1 CMTM5 ST8SIA5	2.10e-04	168	143	5	948d9e9972bd2a4b503d55fa69b70dd568a35a67
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Microglia/Mac\|Myeloid_cells / Location, Cell class and cell subclass	ABCA7 RANBP17 GRK3 SCNN1A KCNQ3	2.15e-04	169	143	5	dba8f5599aa21feef5b7fdfed2e3ab54748d80f7
ToppCell	droplet-Kidney-nan-18m-Epithelial-brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCCC2 ADTRP GALR2 SLC6A13 SLC23A1	2.15e-04	169	143	5	f00741203efa0b948db7223ee8c19bdd0918258a
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPM1E MCCC2 GRK3 SCNN1A DNAH9	2.21e-04	170	143	5	8e774af244cfe787fa0ea2b6be0c3c2d00bfe4fc
ToppCell	droplet-Lung-immune-endo-depleted-3m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPM1E MCCC2 GRK3 SCNN1A DNAH9	2.21e-04	170	143	5	f5140eb9313c0d1bb31f8a761d9c062c56733a61
ToppCell	3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BRIP1 PPM1E RANBP17 TAF6L FOXD3	2.27e-04	171	143	5	b51bbeacb172e8b5de519ada85543d7ae9914b3c
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L5-6_THEMIS_TMEM233\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DCDC1 GRIK4 SLA PTK2B ATP2B4	2.27e-04	171	143	5	fdd96c6fe850bd10e1e0d0f18c4401f8348b7d2c
ToppCell	facs-Skin-nan-24m-Epithelial-epidermal_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRYBG2 HACD2 DGAT2 NAV2 ATP2B4	2.34e-04	172	143	5	5ca89af7406e7e1a055dd60d6f89615f69e62324
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-Red_blood_cells\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HBB HBD HBE1 HBG1 HBG2	2.34e-04	172	143	5	cc1a45a35f78063b2a777ae905f70f894fbcb22f
ToppCell	wk_20-22-Hematologic-Meg-ery-Definitive_erythrocyte\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	HBB HBD HBE1 HBG1 HBG2	2.34e-04	172	143	5	f0b658baa4b41329c95a09387cc55ea046e2333f
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-Red_blood_cells-RBC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HBB HBD HBE1 HBG1 HBG2	2.34e-04	172	143	5	30c57f5ca2326e8d890d9aac8096c64e5b51a24f
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTK2B FANCG GRK3 DGAT2 SCNN1A	2.40e-04	173	143	5	c31076c725f4cd912c56903592a2d9356ae59f54
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTK2B FANCG GRK3 DGAT2 SCNN1A	2.40e-04	173	143	5	a4ed191cfdf6588b7f3672995bf0a4fe9e4b8df6
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TMEM71 FOXD3 CMTM5 ST8SIA5 SLC4A9	2.40e-04	173	143	5	789ab8b2709f4b8728e3733bc72744e9d92ea5ea
ToppCell	18-Distal-RBC-RBC\|Distal / Age, Tissue, Lineage and Cell class	HBD ABCA7 HBB HBG1 HBG2	2.53e-04	175	143	5	7130b816e0c02309c161d8e9ad7cb4bc2469e251
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SPTLC2 ADTRP DMRT2 ST8SIA5 SLC4A9	2.53e-04	175	143	5	77c16e615c0fb9c83f29d7e0a547be72635fac81
ToppCell	facs-Kidney-nan-18m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCCC2 ADTRP GALR2 SLC6A13 SLC23A1	2.53e-04	175	143	5	076ad81d6cbeea5512393d192af3ab5aa1f82975
ToppCell	facs-Kidney-nan-18m-Epithelial-epithelial_cell_of_proximal_tubule\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MCCC2 ADTRP GALR2 SLC6A13 SLC23A1	2.53e-04	175	143	5	445ccb9744a3a9ff37164c532afbe769d306b6c8
ToppCell	18-Distal-RBC\|Distal / Age, Tissue, Lineage and Cell class	HBD ABCA7 HBB HBG1 HBG2	2.53e-04	175	143	5	cc476b4244442418b8f21721a82a36209b556b36
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SPTLC2 ADTRP DMRT2 ST8SIA5 SLC4A9	2.60e-04	176	143	5	c2c4306476989bc2fb30dab00250ef7915842f13
ToppCell	facs-Large_Intestine-Proximal-3m-Epithelial-enterocyte_of_epithelium_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRYBG2 PTPRH DGAT2 KBTBD11 B4GALNT2	2.60e-04	176	143	5	7622f5a8e7320cc7b593141854107ecaf4adff7f
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	NAGLU ADTRP DUOX1 GLE1 VRTN	2.60e-04	176	143	5	e08e7a6dd0208acfbb8646d71915af822a64b5de
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SPTLC2 PPM1E SCNN1A B4GALNT2 SLC4A9	2.60e-04	176	143	5	6c7edf1cb38644500bce6c5a1dd90bbe17415cdb
ToppCell	facs-Large_Intestine-Proximal-18m-Epithelial-nan\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADTRP PNKD NDUFB4 KBTBD11 B4GALNT2	2.60e-04	176	143	5	1f46741b0d2ab64d4e9682587256c8da8893dd91
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-conventional_dendritic_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	NAGLU ADTRP DUOX1 GLE1 VRTN	2.60e-04	176	143	5	b8264cdda75c5145d8bf8ae00b3e05393fe9a92b
ToppCell	wk_15-18-Hematologic-Meg-ery-Definitive_erythrocyte\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	HBB HBD HBE1 HBG1 HBG2	2.60e-04	176	143	5	9af82b976e6a14a3ef7aa50f1f7af2463e5aa5d2
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	NAGLU ADTRP DUOX1 GLE1 VRTN	2.60e-04	176	143	5	4aee9fdada077db7e531684ab938153f84dc8146
ToppCell	facs-Kidney-nan-18m\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NOX4 MCCC2 ADTRP SLC6A13 SLC23A1	2.67e-04	177	143	5	d4cd54c07f1e51b5485270348fb7195d53465027
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma-5\|TCGA-Skin / Sample_Type by Project: Shred V9	GRIK4 DCSTAMP LRP1B SRPX2 ST8SIA5	2.74e-04	178	143	5	ad5cd505ca1cef8ac29b2af7e2c3e01ebc140c14
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SPTLC2 PPM1E SCNN1A B4GALNT2 SLC4A9	2.74e-04	178	143	5	51d2188406f04329311b2efd1108fc36617a860e
ToppCell	facs-Heart-LA-18m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYSLTR2 CRYBG2 SLA SLC6A13 KBTBD11	2.74e-04	178	143	5	d32b4e9c3d1f246ad49e2d8f6497989af68a6c00
ToppCell	facs-Heart-LA-18m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYSLTR2 CRYBG2 SLA SLC6A13 KBTBD11	2.74e-04	178	143	5	b7abf5656233e1a9cdbbe978dfa84d16f14b0be0
ToppCell	LPS_only-Myeloid-Neutrophils\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PTAFR SLA PTK2B AGK MMP8	2.81e-04	179	143	5	d0a03e498afcfeb657037889685ecd77bed07e6c
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L5-6_THEMIS_TMEM233\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GRIK4 GRIK5 SLA PTK2B ATP2B4	2.81e-04	179	143	5	747a32460b257fffca30527b56a74720eb9c12e4
ToppCell	3'_v3-blood-Hematopoietic_Erythro-Mega-Megakaryocyte_early\|blood / Manually curated celltypes from each tissue	CMTM5 HBD HBE1 HBG1 HBG2	2.81e-04	179	143	5	290772eece76d70555dca8b8d82bd88b47e2fc35
ToppCell	LPS_only-Myeloid-Neutrophils-Neutrophils\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PTAFR SLA PTK2B AGK MMP8	2.81e-04	179	143	5	d034651a5a355a58f5e15db627869f4feebdfe35
ToppCell	Multiple_Sclerosis-Other-RBC\|Multiple_Sclerosis / Disease, Lineage and Cell Type	HBD HBB HBE1 HBG1 HBG2	2.81e-04	179	143	5	15763dc59ee6186416e203ffbb450ae4608eba59
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADTRP DMRT2 SLC22A5 KCNQ2 SLC4A9	2.81e-04	179	143	5	27ad6a609fe1f7532b142d0147bccf918704a6dd
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SPTLC2 PPM1E SCNN1A B4GALNT2 SLC4A9	2.88e-04	180	143	5	cfc8bfbfd3617aabbb49f9730c29b673ca157e74
ToppCell	IIH-CD8-CD4_Treg\|IIH / Condition, Cell_class and T cell subcluster	MCCC2 COQ3 TMEM71 HBB TRMT12	2.88e-04	180	143	5	d1a8b25115c80e5a5bd0b8244167a98250ab9778
Drug	colupulone	TMUB1 HBB HBD HBE1 HBG1 HBG2	3.86e-10	16	141	6	CID000373677
Drug	FPL 55712	CACNA2D1 CYSLTR2 PTAFR HBB HBD HBE1 HBG1 HBG2	1.45e-09	54	141	8	CID000105007
Drug	3-iodo-4-hydroxybenzoic acid	PTAFR HBB HBD HBE1 HBG1 HBG2	3.49e-09	22	141	6	CID000449473
Drug	tellimagrandin I	CRYGC HBB HBD HBE1 HBG1 HBG2	3.49e-09	22	141	6	CID000442690
Drug	syntometrine	HBB HBD HBE1 HBG1 HBG2	3.80e-09	11	141	5	CID011979741
Drug	NFPLP	HBB HBD HBE1 HBG1 HBG2	3.80e-09	11	141	5	CID006451852
Drug	N-(2-hydroxypropyl)valine	HBB HBD HBE1 HBG1 HBG2	3.80e-09	11	141	5	CID000130204
Drug	Ferastral	HBB HBD HBE1 HBG1 HBG2	6.49e-09	12	141	5	CID000171553
Drug	2-hydroxylamino-5-ethyl-5-propylbarbituric acid	HBB HBD HBE1 HBG1 HBG2	6.49e-09	12	141	5	CID000128182
Drug	7-methylguanosine 5'-phosphate	HBB HBD HBE1 HBG1 HBG2	6.49e-09	12	141	5	CID000440190
Drug	Vv-hemorphin-7	PTK2B HBB HBD HBE1 HBG1 HBG2	8.15e-09	25	141	6	CID000126533
Drug	pentafluorophenyl isothiocyanate	HBB HBD HBE1 HBG1 HBG2	1.05e-08	13	141	5	CID000123452
Drug	3-aminobiphenyl	HBB HBD HBE1 HBG1 HBG2	1.05e-08	13	141	5	CID000016717
Drug	CO(2	CACNA2D1 SPTLC2 MARS1 MCCC2 COQ3 GGCX TMX2 PTK2B PISD HBB HBD HBE1 HBG1 HBG2 SLC4A9	1.40e-08	378	141	15	CID000000280
Drug	6-amino-m-cresol	HBB HBD HBE1 HBG1 HBG2	1.62e-08	14	141	5	CID000076082
Drug	acetazolamide	CACNA2D1 TMX2 CSE1L HBB HBD HBE1 HBG1 HBG2 SLC4A9	2.22e-08	107	141	9	CID000001986
Drug	NMAM	HBB HBD HBE1 HBG1 HBG2	2.42e-08	15	141	5	CID000013543
Drug	BW12C	HBB HBD HBE1 HBG1 HBG2	2.42e-08	15	141	5	CID000072162
Drug	methyl acetyl phosphate	HBB HBD HBE1 HBG1 HBG2	2.42e-08	15	141	5	CID000170449
Drug	acetylphenylhydrazine	HBB HBD HBE1 HBG1 HBG2 TGS1	3.29e-08	31	141	6	CID000008247
Drug	Gm(5')ppp	HBB HBD HBE1 HBG1 HBG2	3.51e-08	16	141	5	CID000173813
Drug	AC1L3XKM	HBB HBD HBE1 HBG1 HBG2	3.51e-08	16	141	5	CID000123930
Drug	N-(2-hydroxyethyl)valine	HBB HBD HBE1 HBG1 HBG2	4.94e-08	17	141	5	CID000107912
Drug	Rsr 4	HBB HBD HBE1 HBG1 HBG2	4.94e-08	17	141	5	CID000131347
Drug	neokyotorphin	HBB HBD HBE1 HBG1 HBG2	6.81e-08	18	141	5	CID000122173
Drug	AC1L1BA8	HBB HBD HBE1 HBG1 HBG2	6.81e-08	18	141	5	CID000001351
Drug	NSC99363	MARS1 NCBP1 HBB HBD HBE1 HBG1 HBG2 TRMT12	8.95e-08	90	141	8	CID000414014
Drug	Hemorphin 7	HBB HBD HBE1 HBG1 HBG2	9.20e-08	19	141	5	CID000132952
Drug	phenylhydroxylamine	SLA HBB HBD HBE1 HBG1 HBG2	1.19e-07	38	141	6	CID000007518
Drug	glucitollysine	HBB HBD HBE1 HBG1 HBG2	1.22e-07	20	141	5	CID000122288
Drug	C19565	HBB HBD HBE1 HBG1 HBG2	1.22e-07	20	141	5	CID000107819
Drug	S-nitroso-N-acetyl-D,L-penicillamine	SPTLC2 PTK2B GRK2 GRK3 HBB HBD HBE1 HBG1 HBG2	1.57e-07	134	141	9	CID000005231
Drug	S-phenylcysteine	HBB HBD HBE1 HBG1 HBG2	1.59e-07	21	141	5	CID000119462
Drug	iron phosphate	HBB HBD HBE1 HBG1 HBG2	1.59e-07	21	141	5	CID000024861
Drug	lithium 3,5-diiodosalicylate	MARS1 GRIK4 GRIK5 AFP	1.73e-07	9	141	4	CID002735070
Drug	Cilag	HBB HBD HBE1 HBG1 HBG2	2.05e-07	22	141	5	CID000070549
Drug	NSC69862	HBB HBD HBE1 HBG1 HBG2	2.05e-07	22	141	5	CID000072284
Drug	pheophytin	BRIP1 MARS1 UGT1A6 NOX4 DUOX1 AFP HBB HBD HBE1 HBG1 HBG2 SLC23A1	2.15e-07	284	141	12	CID000000250
Drug	Secorvas	CACNA2D1 HBB HBD HBE1 HBG1 HBG2	2.21e-07	42	141	6	CID000003419
Drug	AC1O3MDH	SPTLC2 NOX4 DUOX1 HBB HBD HBE1 HBG1 HBG2	2.38e-07	102	141	8	CID006332158
Drug	Glyset	SMO HBB HBD HBE1 HBG1 HBG2	2.56e-07	43	141	6	CID000051577
Drug	AC1L8FE9	HBB HBD HBE1 HBG1 HBG2	2.61e-07	23	141	5	CID000425294
Drug	n-butyl isocyanide	HBB HBD HBE1 HBG1 HBG2	2.61e-07	23	141	5	CID000076008
Drug	L-histidine beta-naphthylamide	HBB HBD HBE1 HBG1 HBG2	2.61e-07	23	141	5	CID000110993
Drug	NSC-7813	HBB HBD HBE1 HBG1 HBG2	2.61e-07	23	141	5	CID000407619
Drug	potassium	CACNA2D1 SRSF7 MBOAT7 GRIK4 GRIK5 GALR2 GGCX PTK2B GRK2 GRK3 KCNC1 CLPTM1 SCNN1A KCNQ2 KCNQ3 HBB HBD HBE1 HBG1 HBG2 ATP2B4 SLC4A9	2.62e-07	1008	141	22	CID000000813
Drug	LY83583	GRK2 GRK3 HBB HBD HBE1 HBG1 HBG2 CNGA3	2.98e-07	105	141	8	CID000003976
Drug	ferric pyrophosphate	HBB HBD HBE1 HBG1 HBG2	3.28e-07	24	141	5	CID000024877
Drug	Chlorocruorin	HBB HBD HBE1 HBG1 HBG2	4.08e-07	25	141	5	CID005748247
Drug	0225151-0000 [351320-15-5]; Down 200; 10uM; PC3; HT_HG-U133A	CYLD CACNA2D1 CRYBG2 SLA SLC6A13 CRYGC GRK2 GRK3 HBB TGS1	4.33e-07	197	141	10	6389_DN
Drug	DNME	HBB HBD HBE1 HBG1 HBG2	5.03e-07	26	141	5	CID005464045
Drug	thiohydantoin	HBB HBD HBE1 HBG1 HBG2	5.03e-07	26	141	5	CID001274030
Drug	iron (II) d-gluconate dihydrate	HBB HBD HBE1 HBG1 HBG2	5.03e-07	26	141	5	CID000071372
Drug	2,7-diaminofluorene	HBB HBD HBE1 HBG1 HBG2	6.14e-07	27	141	5	CID000010679
Drug	phytate	NAGLU AP2B1 GLE1 HBB HBD HBE1 HBG1 HBG2 SLC4A9	6.71e-07	159	141	9	CID000000890
Drug	ferrous fumarate	PON3 HBB HBD HBE1 HBG1 HBG2	7.26e-07	51	141	6	CID005478817
Drug	urobilinogen	HBB HBD HBE1 HBG1 HBG2	7.43e-07	28	141	5	CID000026818
Drug	betamethasone valerate	HBB HBD HBE1 HBG1 HBG2	7.43e-07	28	141	5	CID000016533
Drug	Lvv-hemorphin-7	HBB HBD HBE1 HBG1 HBG2	8.94e-07	29	141	5	CID000126532
Drug	3-aminophenylboronic acid	MARS1 AP2B1 HBB HBD HBE1 HBG1 HBG2	9.92e-07	85	141	7	CID000092269
Drug	NSC334284	HBB HBD HBE1 HBG1 HBG2	1.07e-06	30	141	5	CID000100101
Drug	dimethyl adipimidate	HBB HBD HBE1 HBG1 HBG2	1.07e-06	30	141	5	CID000025738
Drug	trimidox	HBB HBD HBE1 HBG1 HBG2	1.27e-06	31	141	5	CID005464467
Drug	AC1LA5IX	HBB HBD HBE1 HBG1 HBG2	1.27e-06	31	141	5	CID000462147
Drug	potassium ferricyanide	CYLD HBB HBD HBE1 HBG1 HBG2	1.28e-06	56	141	6	CID000026250
Drug	OD-q	CACNA2D1 GRK2 GRK3 KCNC1 HBB HBD HBE1 HBG1 HBG2	1.80e-06	179	141	9	CID000001456
Drug	5-aminolevulinic acid	EARS2 SLC6A13 AFP HBB HBD HBE1 HBG1 HBG2	2.03e-06	135	141	8	CID000000137
Drug	diaspirin	HBB HBD HBE1 HBG1 HBG2	2.04e-06	34	141	5	CID000065042
Drug	ipenoxazone	GRIK4 GRIK5 LNPK	2.30e-06	5	141	3	CID000065882
Drug	ferric citrate	PNKD HBB HBD HBE1 HBG1 HBG2	2.34e-06	62	141	6	CID000031083
Drug	AC1Q4OK2	CRYGC HBB HBD HBE1 HBG1 HBG2	3.10e-06	65	141	6	CID000005252
Drug	metrifonate	HBB HBD HBE1 HBG1 HBG2	3.15e-06	37	141	5	CID000005853
Drug	InsP5	GLE1 HBB HBD HBE1 HBG1 HBG2	3.39e-06	66	141	6	CID000000482
Drug	AC1Q6S1Y	PIWIL1 SCNN1A HBB HBD HBE1 HBG1 HBG2	3.87e-06	104	141	7	CID000122035
Drug	butadiene monoxide	HBB HBD HBE1 HBG1 HBG2	4.12e-06	39	141	5	CID000013586
Drug	flourish	HBB HBD HBE1 HBG1 HBG2	4.12e-06	39	141	5	CID000009291
Drug	uric acid	NAGLU MCCC2 SLC22A5 HBB HBD HBE1 HBG1 HBG2 SLC23A1	4.30e-06	199	141	9	CID000001175
Drug	1v2w	HBB HBD HBE1 HBG1 HBG2	4.69e-06	40	141	5	CID000131624
Drug	phosphinate	MMP8 HBB HBD HBE1 HBG1 HBG2	4.80e-06	70	141	6	CID000022497
Drug	glipizide	HBB HBD HBE1 HBG1 HBG2	5.31e-06	41	141	5	CID000003478
Drug	6-oxoheptanoic acid	BRIP1 AFP HBB HBD HBE1 HBG1 HBG2	5.97e-06	111	141	7	CID000098810
Drug	isobutyramide	HBB HBD HBE1 HBG1 HBG2	6.00e-06	42	141	5	CID000068424
Drug	CB3717	GRIK4 HBB HBD HBE1 HBG1 HBG2	6.14e-06	73	141	6	CID000001405
Drug	Biliverdin hydrochloride	BRIP1 SGMS1 HBB HBD HBE1 HBG1 HBG2 SLC23A1	6.23e-06	157	141	8	CID000000251
Drug	diepoxybutane	BRIP1 FANCG HBB HBD HBE1 HBG1 HBG2	6.72e-06	113	141	7	CID000011254
Drug	Glu-Lys	HBB HBD HBE1 HBG1 HBG2	6.76e-06	43	141	5	CID005288444
Drug	nitrate	CACNA2D1 BRIP1 EARS2 MARS1 PNKD HBB HBD HBE1 HBG1 HBG2 SLC4A9	7.12e-06	331	141	11	CID000000943
Drug	AC1L1HXY	BRIP1 HBB HBD HBE1 HBG1 HBG2	7.19e-06	75	141	6	CID000004340
Drug	poly (A	NCBP1 HBB HBD HBE1 HBG1 HBG2	7.19e-06	75	141	6	CID000439298
Drug	sitagliptin	HBB HBD HBE1 HBG1 HBG2	7.59e-06	44	141	5	CID004369359
Drug	Ringer's lactate	HBB HBD HBE1 HBG1 HBG2	7.59e-06	44	141	5	CID006335487
Drug	nitrosobenzene	HBB HBD HBE1 HBG1 HBG2	7.59e-06	44	141	5	CID000011473
Drug	M-Hb	SIX3 HBB HBD HBE1 HBG1 HBG2	8.38e-06	77	141	6	CID006122542
Drug	alpha-AASA	HBB HBD HBE1 HBG1 HBG2	8.49e-06	45	141	5	CID000000207
Drug	iron-nitrosyl	HBB HBD HBE1 HBG1 HBG2	8.49e-06	45	141	5	CID000123668
Drug	T-2 toxin	HBB HBD HBE1 HBG1 HBG2	9.48e-06	46	141	5	CID000030552
Drug	propylene oxide	HBB HBD HBE1 HBG1 HBG2	9.48e-06	46	141	5	CID000006378
Drug	Cefotetanum [inn-latin]	HBB HBD HBE1 HBG1 HBG2	9.48e-06	46	141	5	CID000050614
Drug	hydrochlorothiazide	CACNA2D1 SCNN1A HBB HBD HBE1 HBG1 HBG2	9.99e-06	120	141	7	CID000003639
Drug	tempol	APAF1 NOX4 GRIK4 GRIK5 DUOX1 GRK2 GRK3 AP1B1 AP2B1	1.00e-05	221	141	9	CID000137994
Disease	Delta-Beta Thalassemia	HBB HBD HBG1	9.79e-08	3	137	3	C0271985
Disease	FETAL HEMOGLOBIN QUANTITATIVE TRAIT LOCUS 1	HBB HBG1 HBG2	9.79e-08	3	137	3	141749
Disease	Hereditary persistence of fetal hemoglobin	HBB HBG1 HBG2	9.79e-08	3	137	3	cv:C0019025
Disease	delta beta-thalassemia (is_implicated_in)	HBB HBG1 HBG2	9.79e-08	3	137	3	DOID:0080773 (is_implicated_in)
Disease	FETAL HEMOGLOBIN QUANTITATIVE TRAIT LOCUS 1	HBB HBG1 HBG2	3.90e-07	4	137	3	C1841621
Disease	Thromboembolism	HBD HBD HBE1 HBG1 HBG2	1.88e-06	44	137	5	HP_0001907
Disease	obsolete_red blood cell distribution width	BRIP1 SPTLC2 HBD AK9 PNKD ABCA7 KSR1 CLPTM1L SGMS1 PTPRH AP2B1 CNIH4 SLC22A5 CLPTM1 HBB HBD HBE1 HBG2 SLC23A1 ATP2B4	4.27e-06	1347	137	20	EFO_0005192
Disease	Benign neonatal seizures	KCNQ2 KCNQ3	2.14e-05	2	137	2	cv:C0220669
Disease	benign neonatal seizures (implicated_via_orthology)	KCNQ2 KCNQ3	2.14e-05	2	137	2	DOID:14264 (implicated_via_orthology)
Disease	Hemoglobin F Disease	HBB HBG1 HBG2	4.28e-05	15	137	3	C0019025
Disease	sickle cell anemia (is_implicated_in)	HBB HBE1 HBG2	5.25e-05	16	137	3	DOID:10923 (is_implicated_in)
Disease	benign neonatal seizures (is_implicated_in)	KCNQ2 KCNQ3	6.40e-05	3	137	2	DOID:14264 (is_implicated_in)
Disease	beta thalassemia (implicated_via_orthology)	HBB HBD	6.40e-05	3	137	2	DOID:12241 (implicated_via_orthology)
Disease	inferior parietal cortex volume measurement	CRYGC HBE1 HBG2	8.98e-05	19	137	3	EFO_0010307
Disease	corpus callosum volume measurement	CACNA2D1 LAMC2 SLA TMX2 SLC4A9	1.06e-04	100	137	5	EFO_0010299
Disease	Uveal Melanoma	CACNA2D1 LRP1B CLPTM1L AP2B1	1.09e-04	53	137	4	EFO_1000616
Disease	malaria	IARS1 HBB HBE1 HBG2 ATP2B4	1.16e-04	102	137	5	EFO_0001068
Disease	hemoglobin measurement, fetal hemoglobin measurement	HBE1 HBG2	1.28e-04	4	137	2	EFO_0004509, EFO_0004576
Disease	hemoglobin measurement, hemoglobin A2 measurement	HBD HBD	2.12e-04	5	137	2	EFO_0004509, EFO_0005845
Disease	Familial benign neonatal epilepsy	KCNQ2 KCNQ3	3.17e-04	6	137	2	C0220669
Disease	hemoglobin E disease	HBD HBD	3.17e-04	6	137	2	MONDO_0016243
Disease	Global developmental delay	GTF3C3 TMX2 NBAS AP1B1 LNPK	4.00e-04	133	137	5	C0557874
Disease	anemia (biomarker_via_orthology)	HBB HBD	4.43e-04	7	137	2	DOID:2355 (biomarker_via_orthology)
Disease	blood sedimentation	HBE1 HBG2	4.43e-04	7	137	2	EFO_0004304
Disease	Chloracne	HBB HBD HBG1	4.82e-04	33	137	3	C0263454
Disease	sickle cell anemia	HBE1 HBG2	5.88e-04	8	137	2	MONDO_0011382
Disease	primary bacterial infectious disease (implicated_via_orthology)	DUOX1 SMO	7.54e-04	9	137	2	DOID:0050338 (implicated_via_orthology)
Disease	long QT syndrome (implicated_via_orthology)	KCNQ2 KCNQ3	9.40e-04	10	137	2	DOID:2843 (implicated_via_orthology)
Disease	Major Depressive Disorder	APAF1 GRIK4 GALR2 SLC6A13 FOXD3 MMP8	9.82e-04	243	137	6	C1269683
Disease	Alzheimer disease, educational attainment	LRP1B ABCA7 PTK2B ERCC8 CLPTM1 PISD	1.07e-03	247	137	6	EFO_0011015, MONDO_0004975
Disease	Malignant Head and Neck Neoplasm	CYLD BRIP1 FANCG	1.13e-03	44	137	3	C0278996
Disease	Shortened QT interval	CACNA2D1 SLC22A5	1.15e-03	11	137	2	C0151879
Disease	Intellectual Disability	NAGLU DPF2 GTF3C3 TMX2 SNX14 AP1B1 PISD LNPK	1.19e-03	447	137	8	C3714756
Disease	reticulocyte count	PNKD GGCX TMX2 DMRT2 PTPRH AP1B1 AP2B1 CNIH4 SLC22A5 HBE1 HBG2 SLC23A1 ATP2B4	1.19e-03	1045	137	13	EFO_0007986
Disease	amino acid measurement	CACNA2D1 BRIP1 DCDC1 GRIK5 PNKD NBAS SLC6A13 SLC22A5 HBE1 HBG2	1.29e-03	678	137	10	EFO_0005134
Disease	Unipolar Depression	APAF1 GRIK4 GALR2 SLC6A13 FOXD3 MMP8	1.36e-03	259	137	6	C0041696
Disease	neutrophil measurement	PNKD TTLL12 FAT2 CNIH4 SLC23A1	1.45e-03	177	137	5	EFO_0803548
Disease	developmental and epileptic encephalopathy (implicated_via_orthology)	KCNQ2 KCNQ3	1.61e-03	13	137	2	DOID:0112202 (implicated_via_orthology)
Disease	Skin Abnormalities	APAF1 AP1B1	1.61e-03	13	137	2	C0037268
Disease	seasonal gut microbiome measurement	DCDC1 SPTLC2 TEKT5 NAV2	1.87e-03	112	137	4	EFO_0007753
Disease	fertility measurement	NBAS NAV2	1.88e-03	14	137	2	EFO_0006923
Disease	Fanconi anemia	BRIP1 FANCG	1.88e-03	14	137	2	cv:C0015625
Disease	response to acetylsalicylate	CACNA2D1 KLHL18	2.46e-03	16	137	2	GO_1903492
Disease	urate measurement, spine bone mineral density	CACNA2D1 UGT1A6 NAV2	2.51e-03	58	137	3	EFO_0004531, EFO_0007701
Disease	adverse effect, response to xenobiotic stimulus	LRP1B SCNN1A NAV2	2.63e-03	59	137	3	EFO_0009658, GO_0009410
Disease	Bone marrow hypocellularity	BRIP1 FANCG	3.12e-03	18	137	2	C1855710
Disease	Seizures	GTF3C3 TMX2 KCNQ2 LNPK PIGM	3.57e-03	218	137	5	C0036572
Disease	Microcephaly	IARS1 TMX2 PISD	3.78e-03	67	137	3	C0025958
Disease	renal system measurement	DCDC1 GRIK5	3.85e-03	20	137	2	EFO_0004742
Disease	energy expenditure measurement	CACNA2D1 KCNC1	3.85e-03	20	137	2	EFO_0008005
Disease	fetal hemoglobin measurement	HBE1 HBG2	4.24e-03	21	137	2	EFO_0004576
Disease	activities of daily living score measurement	PIWIL1 GRIK5	4.24e-03	21	137	2	EFO_0008451
Disease	family history of Alzheimer’s disease	ABCA7 PTK2B CLPTM1	4.44e-03	71	137	3	EFO_0009268

Protein segments in the cluster

Peptide	Gene	Start	Entry
LRDFPNRWEYYLKQL	APAF1	331	O14727
SRDYSLDYLPFRLWV	SLC4A9	486	Q96Q91
YRRILRRLASYWAQP	AGK	276	Q53H12
PFLTQWQRRYFYLFP	GRK3	571	P35626
TRWYRAPELLYGARQ	CDK20	166	Q8IZL9
NPDLRDRGYIYWRLL	AP2B1	516	P63010
RLRNLFSYDGIWLFP	B4GALNT2	121	Q8NHY0
LNRIKSFRYPWARLY	COQ3	71	Q9NZJ6
FRVRVWKPYAVYLLN	GPR31	41	O00270
AFWILFLYNRDLIYP	ADTRP	101	Q96IZ2
VLDLRRWYCISRPQY	BIVM	196	Q86UB2
LYAAIIQLRWPYGNR	GLE1	576	Q53GS7
NPDLRDRGYIYWRLL	AP1B1	516	Q10567
YFVIDNFVINRRPWL	ATP2B4	381	P23634
RLAAFWYYTTVELVP	ATP5MGL	26	Q7Z4Y8
SLYLPYVLCVAWRDR	ABCA7	666	Q8IZY2
PFLTQWQRRYFYLFP	GRK2	571	P25098
LVANYYTPRWRLFLE	NAGLU	666	P54802
SFRWYLENVYPELTV	GALNT16	411	Q8N428
PKWERTNLTYRIRNY	MMP8	106	P22894
YWGRYEPVISRTLQF	RANBP17	601	Q9H2T7
QVLLYRIRFYFPNWF	JAK3	96	P52333
REPFLQALGLLWFRY	DUOX1	241	Q9NRD9
LQWRVPLFLIFLSFY	OR9Q2	21	Q8NGE9
WVSYGRAYRSPLNLA	DCDC1	576	M0R2J8
PMALTIDYVNRRLYW	LRP1B	3176	Q9NZR2
VPQVRRDWYVYAFLS	NCBP1	161	Q09161
AYSPRFLYIWPNARI	MCCC2	456	Q9HCC0
RLLVVYPWTQRFFDS	HBE1	31	P02100
ILGLYRIPYWRTDNN	LIPJ	26	Q5W064
IYDALERPRGWALLY	KCNQ3	111	O43525
AAWRYYATNPNRIDL	KCNQ3	381	O43525
FAFAYLQLWRLLLYR	GPR137C	61	Q8N3F9
YLAEPQWAVRYRIIS	FAT2	61	Q9NYQ8
TLAPLDREFASYYWL	FAT2	1091	Q9NYQ8
LYNVLERPRGWAFIY	KCNQ2	81	O43526
YPRFSDWLYTFNVRP	KSR1	106	Q8IVT5
IWVLFAAVDYLLYRL	DCSTAMP	306	Q9H295
PFFRYRTYLDWLEQP	MBOAT7	166	Q96N66
LTSLFLWIRTAYPRF	MT-ND1	266	P03886
LWIRTAYPRFRYDQL	MT-ND1	271	P03886
LYLESYLSWIRPSDR	FANCG	591	O15287
LRWAYARTINVYPNF	NDUFB4	66	O95168
IRDRLLFLRQYIWYS	NBAS	56	A2RRP1
RIPWFQYPIIYDIRA	PHB2	71	Q99623
RQEILAVSWSPRYDY	ERCC8	186	Q13216
PYKLRRLYFIWVCRD	NOX4	451	Q9NPH5
WVKDFPLRRRPQLYY	PPM1E	216	Q8WY54
LPGRQWYEIQAYRAL	BRIP1	811	Q9BX63
TYARTLRYLWRAVDP	GALR2	206	O43603
YFISRDWKLDPVLYR	GLG1	551	Q92896
LAWVRYDREQRGPYL	KLHL18	206	O94889
IWALFEDPYSSRYAR	KCNC1	176	P48547
TYRQYPLSSRFLVWP	DMRT2	331	Q9Y5R5
EWYFLFAYTILRSVP	MT-CYB	271	P00156
NKIDLYDVRRRPWYI	CACNA2D1	231	P54289
YDQAFPISLIRYWVL	GJA9	66	P57773
AEWRRRGYAPLLYLQ	FUT11	201	Q495W5
PYLIKWARYTLFIVL	HACD2	161	Q6Y1H2
RLLVVYPWTQRFFDS	HBG1	31	P69891
LYPIKQRRVYFRLWN	CRYBG2	1521	Q8N1P7
EFYLKIIPWRLYTFR	AREL1	366	O15033
RLPNPDTDLYWFTLY	MCHR1	266	Q99705
RGLYDFYLPREELWI	KLHDC2	56	Q9Y2U9
NWSPQLSYFEYRRLL	LAMC2	326	Q13753
WVLYELPNYRGRQYL	CRYGC	131	P07315
KYRQSLLDRTWRPYL	DNAH9	3396	Q9NYC9
RLLVVYPWTQRFFES	HBD	31	P02042
RLLVVYPWTQRFFES	HBB	31	P68871
EWRYDLQIRYLPEDF	PTK2B	126	Q14289
DEPVLLRFYYWLSQT	CENPI	381	Q92674
VTSPYWEERIFYLLL	CYLD	11	Q9NQC7
VLFLVARLTPYEWYS	GRIK4	561	Q16099
LFLAARLSPYEWYNP	GRIK5	561	Q16478
RLLVVYPWTQRFFDS	HBG2	31	P69892
TYRDIWDFLRQLFVP	FLAD1	521	Q8NFF5
WDFLRQLFVPYCILY	FLAD1	526	Q8NFF5
CLVPDLWIRYSQYLD	SART3	341	Q15020
WYRFHYINILSRLPE	SCNN1A	251	P37088
AYVLAWLLLQYLPRR	SLC22A5	386	O76082
AVWRYFRDYFPIQLV	DGAT2	131	Q96PD7
LYNRYEEPNAWRISR	DHX8	1201	Q14562
PYYREKFPAWQNSIR	FOXD3	176	Q9UJU5
PFLYAPTILLWAARY	AFP	171	P02771
KPLDNWLLIYTRRNY	PIWIL1	491	Q96J94
RLPNNWYYISPRLTF	SLA	136	Q13239
EPLVRQLLSSYQFYW	RTL1	831	A6NKG5
PSRYWLGAYQLQRVV	RXFP4	196	Q8TDU9
RPARRWALSDYSLYL	TAF6L	606	Q9Y6J9
RTLASYKLIAPRYRW	AK9	316	Q5TCS8
TWLGYLFYRQQLRRA	PNKD	86	Q8N490
CRRSPRLLTNGYYIW	TMEM71	61	Q6P5X7
PSLRKVVWRYLLNVY	TBC1D25	231	Q3MII6
SWPLRVLAEYRTAYA	TMEM151B	311	Q8IW70
YLTVDRNRLWYVPRH	LRRC28	161	Q86X40
IANGYVLWVFARLYP	PTAFR	31	P25105
PFEYIYFRSRRLVVW	PNPLA5	351	Q7Z6Z6
LWNYSIIPYLLEAVR	NAV2	2361	Q8IVL1
RNYWYFTPPNLERLR	SGSM2	806	O43147
RVLRALAWLYPEIGY	SGSM3	186	Q96HU1
RTRSLLREWYLQDPY	SIX3	216	O95343
EKWRRPFYRVLQVYE	ST8SIA5	226	O15466
LPGYRYLNSWRPSLF	TEKT5	41	Q96M29
DVLLPWYNAYRFLIQ	IARS1	651	P41252
LFYRLLKYDPRRDEW	KBTBD11	466	O94819
QLSRFNRYYSLWIPE	URB1	851	O60287
NRYYSLWIPEQAREA	URB1	856	O60287
YSYLWTRPAVGRAQL	EARS2	421	Q5JPH6
LAWRYFLPPYTFQIR	SNAPC1	61	Q16533
YEPTNVRYLWERSSL	GTF3C3	246	Q9Y5Q9
YLYQRWLYPVDKRRV	CLPTM1L	506	Q96KA5
YLYQRWIYRVDPTRV	CLPTM1	581	O96005
YYQRFDRINWPCLLQ	CMTM5	81	Q96DZ9
NLYYRWLTAIALPVF	CNGA3	166	Q16281
ALPVFYNWYLLICRA	CNGA3	176	Q16281
LPFRADYYLRGSNWI	CYSLTR2	91	Q9NS75
FLLNLPVATWNIYRY	CNIH4	71	Q9P003
DRPAYLWLKQRAYNL	TAS2R5	111	Q9NYW4
VYSVPRLSRWLAQPY	TMX2	11	Q9Y320
RLSRWLAQPYYLLSA	TMX2	16	Q9Y320
FQRYLPRFVTAIWNL	CSE1L	286	P55060
RISCVLFLLPYWYVF	GGCX	136	P38435
DLWVNPLRYYLRERG	TSPYL2	386	Q9H2G4
QYLRNLTFLLPVYRW	SLC23A1	226	Q9UHI7
LELVLENFVYPWYRD	SNX14	141	Q9Y5W7
LTLFGYLRDFLRYWR	SPTLC2	81	O15270
LDYRVPRWCYTLNIQ	SRPX2	51	O60687
RRPVYSLYIWTFGVN	PISD	136	Q9UG56
GIQFYLYPNLTRLWD	SLC6A13	261	Q9NSD5
FSYYGPLRTVWIARN	SRSF7	31	Q16629
RAAAPYLLRTLLYWA	TMEM102	401	Q8N9M5
YLLRTLLYWACERLP	TMEM102	406	Q8N9M5
LLYWACERLPALYLA	TMEM102	411	Q8N9M5
NYLARRWYVPVKDLL	GPLD1	176	P80108
LASGQLYSYPARRWR	DPF2	66	Q92785
LTYLFIKEYSPRRLW	SGMS1	291	Q86VZ5
ILDLRWTYVLFYSPR	PON3	196	Q15166
RELYPVEFRNLLKWY	TMEM97	36	Q5BJF2
TITLLWALYYDRREP	TSPAN12	241	O95859
WRNSNRYPAVILFYV	SMO	256	Q99835
RPLRLFVYDVFWLRF	TTLL12	481	Q14166
QPRWFVLDNGILSYY	PLEKHA3	16	Q9HB20
EPWFTQRYREYLQRQ	TRMT12	26	Q53H54
FSPLISLWINRFYIY	TYW1	11	Q9NV66
VPELAKYWAQRYRLF	TGS1	641	Q96RS0
SVWLLRYDFVLEYPR	UGT1A6	251	P19224
LLLLLWYCQIQYRPF	TMUB1	206	Q9BVT8
LQRFPEISRSTYYAW	VRTN	336	Q9H8Y1
RATYRYTPLLGWLLT	PIGM	71	Q9H3S5
AKNRYRNVLPYDWSR	PTPRH	846	Q9HD43
GIPADIWRFYLLYIR	MARS1	611	P56192
IWRFYLLYIRPEGQD	MARS1	616	P56192
TYSPLLYWINKRRRY	TEX38	61	Q6PEX7
VYLWYLPDEFTARLA	LNPK	61	Q9C0E8