Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionbenzodiazepine receptor binding

RIMBP3 RIMBP3B RIMBP3C

2.15e-095133GO:0030156
GeneOntologyBiologicalProcessneuromuscular synaptic transmission

RIMBP3 RIMBP3B RIMBP3C

1.38e-0636133GO:0007274
GeneOntologyBiologicalProcessspermatid development

RIMBP3 RIMBP3B RIMBP3C

5.27e-04262133GO:0007286
GeneOntologyBiologicalProcessfertilization

RIMBP3 RIMBP3B RIMBP3C

5.33e-04263133GO:0009566
GeneOntologyBiologicalProcessspermatid differentiation

RIMBP3 RIMBP3B RIMBP3C

5.88e-04272133GO:0048515
GeneOntologyCellularComponentmanchette

RIMBP3 RIMBP3B RIMBP3C

6.10e-0728133GO:0002177
MousePhenoectopic manchette

RIMBP3 RIMBP3B RIMBP3C

3.49e-0719113MP:0009377
MousePhenodetached sperm flagellum

RIMBP3 RIMBP3B RIMBP3C

4.78e-0721113MP:0008893
MousePhenodetached acrosome

RIMBP3 RIMBP3B RIMBP3C

4.72e-0644113MP:0009231
MousePhenoabnormal manchette morphology

RIMBP3 RIMBP3B RIMBP3C

5.05e-0645113MP:0009376
MousePhenokinked sperm flagellum

RIMBP3 RIMBP3B RIMBP3C

9.82e-0656113MP:0009237
MousePhenoabnormal sperm nucleus morphology

RIMBP3 RIMBP3B RIMBP3C

2.28e-0574113MP:0009232
MousePhenoabnormal acrosome morphology

RIMBP3 RIMBP3B RIMBP3C

2.23e-04159113MP:0008898
MousePhenoimpaired fertilization

RIMBP3 RIMBP3B RIMBP3C

4.77e-04206113MP:0000242
MousePhenoabnormal spermatid morphology

RIMBP3 RIMBP3B RIMBP3C

5.55e-04217113MP:0006380
MousePhenoabnormal fertilization

RIMBP3 RIMBP3B RIMBP3C

5.86e-04221113MP:0005410
MousePhenoabnormal spermiogenesis

RIMBP3 RIMBP3B RIMBP3C

7.18e-04237113MP:0001932
MousePhenoabnormal sperm head morphology

RIMBP3 RIMBP3B RIMBP3C

9.50e-04261113MP:0009230
MousePhenoabnormal heart size

SHC1 ACACB SS18 TMPRSS2 LRRTM2

1.27e-031180115MP:0005406
MousePhenoabnormal sperm flagellum morphology

RIMBP3 RIMBP3B RIMBP3C

1.35e-03295113MP:0008892
DomainSH3_9

RIMBP3 RIMBP3B RIMBP3C

1.94e-0578133PF14604
DomainSH3_2

RIMBP3 RIMBP3B RIMBP3C

2.61e-0586133IPR011511
DomainSH3_2

RIMBP3 RIMBP3B RIMBP3C

2.61e-0586133PF07653
DomainFN3

RIMBP3 RIMBP3B RIMBP3C

3.15e-04199133PS50853
DomainFN3_dom

RIMBP3 RIMBP3B RIMBP3C

3.64e-04209133IPR003961
DomainSH3

RIMBP3 RIMBP3B RIMBP3C

4.00e-04216133PS50002
DomainSH3

RIMBP3 RIMBP3B RIMBP3C

4.00e-04216133SM00326
DomainSH3_domain

RIMBP3 RIMBP3B RIMBP3C

4.23e-04220133IPR001452
DomainFN3

RIMBP3B RIMBP3C

7.08e-03185132SM00060
Domain-

RIMBP3 RIMBP3B RIMBP3C

9.76e-036631332.60.40.10
DomainIg-like_fold

RIMBP3 RIMBP3B RIMBP3C

1.16e-02706133IPR013783
Pubmed

RIM-BP3 is a manchette-associated protein essential for spermiogenesis.

RIMBP3 RIMBP3B RIMBP3C

1.63e-10413319091768
Pubmed

Structure and evolution of RIM-BP genes: identification of a novel family member.

RIMBP3 RIMBP3B RIMBP3C

4.08e-10513317855024
Pubmed

Integrative characterization of germ cell-specific genes from mouse spermatocyte UniGene library.

RIMBP3 RIMBP3B RIMBP3C

1.48e-081413317662146
Pubmed

Analysis of laser-microdissected prostate cancer tissues reveals potential tumor markers.

GATA3 TMPRSS2

4.64e-06913221743959
Cytoband22q11.21

RIMBP3 RIMBP3B RIMBP3C

3.87e-0611113322q11.21
CytobandEnsembl 112 genes in cytogenetic band chr22q11

RIMBP3 RIMBP3B RIMBP3C

2.02e-04419133chr22q11
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L6_LAMP5_C1QL2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RIMBP3 RIMBP3B RIMBP3C

1.69e-0517813339889db130216655a34796e7030ffeb372465500
ToppCelldroplet-Kidney-nan-18m-Epithelial-kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACACB GATA3 TMPRSS2

2.06e-05190133c408d4033a130c0168159a5b6f286fd2b2a9a39d
ToppCelldroplet-Kidney-nan-18m-Epithelial-Epcam____kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACACB GATA3 TMPRSS2

2.06e-05190133d4910c37045a8b8bb53b37625263bc0a47b6e3f8
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW10-Mesenchymal|GW10 / Sample Type, Dataset, Time_group, and Cell type.

SHC1 CDK8 DENND4A

2.39e-052001335c638c80661017c85f9390f1b398ac7728c8f001
ComputationalNeighborhood of TPR

CDK8 SS18 DENND4A

1.98e-0414793MORF_TPR
ComputationalNeighborhood of DDB1

SS18 ATXN2L DENND4A

8.98e-0424693MORF_DDB1
DrugHydrocortisone base [50-23-7]; Up 200; 11uM; MCF7; HT_HG-U133A

ACACB SS18 TMPRSS2 ATXN2L

1.61e-061941143284_UP
DrugZuclopenthixol hydrochloride [633-59-0]; Up 200; 9.2uM; MCF7; HT_HG-U133A

SS18 TMPRSS2 ATXN2L

8.04e-051831134843_UP
DrugNifuroxazide [965-52-6]; Down 200; 14.6uM; MCF7; HT_HG-U133A

SS18 TMPRSS2 DENND4A

9.13e-051911132850_DN
DrugEtifenin [63245-28-3]; Down 200; 12.4uM; HL60; HT_HG-U133A

ACACB SS18 ATXN2L

9.41e-051931132477_DN
DrugTrihexyphenidyl-D,L Hydrochloride [58947-95-8]; Up 200; 11.8uM; MCF7; HT_HG-U133A

ACACB TMPRSS2 ATXN2L

9.41e-051931134133_UP
DrugLidoflazine [3416-26-0]; Down 200; 8.2uM; MCF7; HT_HG-U133A

ACACB TMPRSS2 DENND4A

9.70e-051951133201_DN
DrugNomegestrol acetate [58652-20-3]; Up 200; 10.8uM; MCF7; HT_HG-U133A

ACACB TMPRSS2 ATXN2L

9.85e-051961135461_UP
DrugNorfloxacin [70458-96-7]; Down 200; 12.6uM; PC3; HT_HG-U133A

ACACB GATA3 SS18

9.85e-051961132090_DN
DrugAmbroxol hydrochloride [23828-92-4]; Up 200; 9.6uM; MCF7; HT_HG-U133A

ACACB TMPRSS2 ATXN2L

9.85e-051961133238_UP
DrugIsoxicam [34552-84-6]; Up 200; 12uM; PC3; HT_HG-U133A

ACACB SS18 DENND4A

9.85e-051961131820_UP
DrugMetaraminol bitartrate [33402-03-8]; Down 200; 8.6uM; MCF7; HT_HG-U133A

SS18 TMPRSS2 ATXN2L

9.85e-051961132298_DN
DrugBetonicine [515-25-3]; Down 200; 25.2uM; MCF7; HT_HG-U133A

TMPRSS2 ATXN2L DENND4A

1.00e-041971134767_DN
Drug0175029-0000 [211245-78-2]; Down 200; 1uM; PC3; HT_HG-U133A

ACACB SS18 DENND4A

1.00e-041971133694_DN
DrugAtropine sulfate monohydrate [5908-99-6]; Down 200; 5.8uM; PC3; HT_HG-U133A

ACACB GATA3 SS18

1.00e-041971135865_DN
DrugRifampicin [13292-46-1]; Up 200; 4.8uM; MCF7; HT_HG-U133A

ACACB TMPRSS2 ATXN2L

1.02e-041981134126_UP
DrugClopamide [636-54-4]; Down 200; 11.6uM; PC3; HT_HG-U133A

ACACB GATA3 SS18

1.02e-041981136301_DN
DrugNafronyl oxalate [3200-06-4]; Down 200; 8.4uM; PC3; HT_HG-U133A

ACACB GATA3 DENND4A

1.02e-041981136687_DN
DrugICI 182,780; Up 200; 0.01uM; PC3; HT_HG-U133A

GATA3 TMPRSS2 ATXN2L

1.02e-041981134462_UP
DrugAG-012559 [369370-06-9]; Down 200; 10uM; MCF7; HT_HG-U133A

SS18 ATXN2L DENND4A

1.02e-041981136889_DN
DrugDNA-PK Inhibitor III; Down 200; 1uM; PC3; HT_HG-U133A

ACACB GATA3 ATXN2L

1.03e-041991137548_DN
DrugParoxetine maleate [64006-44-6]; Up 200; 1uM; PC3; HT_HG-U133A

ACACB TMPRSS2 ATXN2L

1.03e-041991133821_UP
DrugOxytetracycline dihydrate [6153-64-6]; Up 200; 8uM; PC3; HT_HG-U133A

ACACB GATA3 ATXN2L

1.03e-041991135772_UP
DrugVitexin [3681-93-4]; Down 200; 9.2uM; MCF7; HT_HG-U133A

TMPRSS2 ATXN2L DENND4A

1.05e-042001134413_DN
DrugStrophanthidin [66-28-4]; Up 200; 9.8uM; MCF7; HT_HG-U133A

TMPRSS2 ATXN2L

2.85e-031681126087_UP
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A

GATA3 TMPRSS2

2.98e-031721122330_DN
Drugtrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

GATA3 SS18

3.12e-031761127499_DN
Drug15d-PGJ2; Down 200; 10uM; MCF7; HT_HG-U133A_EA

GATA3 SS18

3.16e-031771121069_DN
Druglomustine; Down 200; 100uM; PC3; HT_HG-U133A

ACACB GATA3

3.26e-031801127094_DN
Drugdaunorubicin HCl; Up 200; 1uM; MCF7; HT_HG-U133A

SS18 TMPRSS2

3.37e-031831127507_UP
DrugMycophenolic acid [24280-93-1]; Up 200; 12.4uM; MCF7; HT_HG-U133A

ACACB ATXN2L

3.44e-031851124137_UP
Drug2-deoxy-D-glucose; Up 200; 10000uM; MCF7; HG-U133A

TMPRSS2 ATXN2L

3.48e-03186112344_UP
DrugMifepristone [84371-65-3]; Up 200; 9.4uM; MCF7; HT_HG-U133A

SS18 DENND4A

3.51e-031871127183_UP
DrugRapamycin; Up 200; 0.1uM; MCF7; HT_HG-U133A

SS18 TMPRSS2

3.51e-031871125204_UP
Drugtroglitazone; Down 200; 10uM; PC3; HT_HG-U133A

GATA3 ATXN2L

3.55e-031881124456_DN
DrugIsoflupredone acetate [338-98-7]; Up 200; 9.6uM; PC3; HT_HG-U133A

ACACB SS18

3.55e-031881121832_UP
DrugGSK-3beta Inhibitor VIII; Down 200; 10uM; PC3; HT_HG-U133A

ACACB SS18

3.55e-031881127097_DN
DrugMethiothepin maleate [19728-88-2]; Up 200; 8.4uM; MCF7; HT_HG-U133A

ACACB ATXN2L

3.59e-031891125413_UP
DrugMinocycline hydrochloride [13614-98-7]; Up 200; 8uM; HL60; HT_HG-U133A

ACACB ATXN2L

3.59e-031891122405_UP
DrugNocodazole [31430-18-9]; Down 200; 13.2uM; PC3; HT_HG-U133A

GATA3 SS18

3.63e-031901127145_DN
DrugPropantheline bromide [50-34-0]; Down 200; 9uM; MCF7; HT_HG-U133A

SS18 TMPRSS2

3.63e-031901123352_DN
DrugTTNPB; Up 200; 0.1uM; MCF7; HG-U133A

ACACB TMPRSS2

3.63e-03190112223_UP
Drug2-propylpentanoic acid; Up 200; 500uM; MCF7; HT_HG-U133A

ACACB TMPRSS2

3.63e-031901125237_UP
DrugPromazine hydrochloride [53-60-1]; Up 200; 12.4uM; MCF7; HT_HG-U133A

TMPRSS2 ATXN2L

3.66e-031911126028_UP
Drugthioridazine hydrochloride; Down 200; 10uM; PC3; HT_HG-U133A

ACACB GATA3

3.66e-031911124454_DN
Drugretinoic acid; Up 200; 1uM; MCF7; HG-U133A

ACACB TMPRSS2

3.66e-03191112224_UP
DrugMeclofenoxate hydrochloride [3685-84-5]; Down 200; 13.6uM; MCF7; HT_HG-U133A

ACACB SS18

3.66e-031911123605_DN
DrugTracazolate hydrochloride [41094-88-6]; Up 200; 11.8uM; MCF7; HT_HG-U133A

ACACB TMPRSS2

3.66e-031911127339_UP
DrugAlprenolol hydrochloride [13707-88-5]; Down 200; 14uM; MCF7; HT_HG-U133A

ACACB TMPRSS2

3.70e-031921123188_DN
DrugFusaric acid [536-69-6]; Down 200; 22.4uM; MCF7; HT_HG-U133A

SS18 TMPRSS2

3.70e-031921123245_DN
DrugMonobenzone [103-16-2]; Up 200; 20uM; MCF7; HT_HG-U133A

ACACB TMPRSS2

3.70e-031921123391_UP
Drug17-AAG; Down 200; 1uM; HL60; HT_HG-U133A

SS18 ATXN2L

3.70e-031921126166_DN
DrugNorethindrone [68-22-4]; Up 200; 13.4uM; HL60; HT_HG-U133A

GATA3 SS18

3.70e-031921122383_UP
DrugN6-methyladenosine [1867-73-8]; Down 200; 14.2uM; HL60; HT_HG-U133A

SS18 DENND4A

3.70e-031921121271_DN
DrugEtofenamate [30544-47-9]; Up 200; 10.8uM; MCF7; HT_HG-U133A

ACACB ATXN2L

3.70e-031921124108_UP
DrugCotinine (-) [486-56-6]; Down 200; 22.6uM; PC3; HT_HG-U133A

SS18 DENND4A

3.74e-031931124650_DN
DrugAG-028671 [847803-03-6]; Up 200; 10uM; MCF7; HT_HG-U133A

SS18 TMPRSS2

3.74e-031931126587_UP
Drugprochlorperazine dimaleate salt; Up 200; 10uM; MCF7; HG-U133A

TMPRSS2 ATXN2L

3.74e-03193112455_UP
DrugOxymetazoline hydrochloride [2315-02-8]; Down 200; 13.4uM; PC3; HT_HG-U133A

GATA3 SS18

3.74e-031931122114_DN
DrugClemizole hydrochloride [1163-36-6]; Down 200; 11uM; PC3; HT_HG-U133A

ACACB SS18

3.74e-031931127371_DN
DrugProgesterone [57-83-0]; Down 200; 12.8uM; PC3; HT_HG-U133A

ACACB SS18

3.74e-031931126646_DN
DrugCoralyne chloride hydrate [38989-38-7]; Up 200; 9.6uM; MCF7; HT_HG-U133A

ATXN2L DENND4A

3.78e-031941125418_UP
DrugAzacyclonol [115-46-8]; Up 200; 15uM; MCF7; HT_HG-U133A

ACACB ATXN2L

3.78e-031941125398_UP
DrugEquilin [474-86-2]; Down 200; 15uM; MCF7; HT_HG-U133A

SS18 ATXN2L

3.78e-031941123377_DN
DrugNortriptyline hydrochloride [894-71-3]; Up 200; 13.4uM; HL60; HT_HG-U133A

ACACB GATA3

3.78e-031941122391_UP
DrugBeta-Escin [11072-93-8]; Down 200; 3.2uM; PC3; HT_HG-U133A

GATA3 ATXN2L

3.78e-031941123807_DN
DrugCP-690334-01 [459212-38-5]; Down 200; 1uM; PC3; HT_HG-U133A

GATA3 ATXN2L

3.78e-031941123826_DN
DrugDinoprost trometamol [38362-01-5]; Up 200; 8.4uM; MCF7; HT_HG-U133A

SS18 ATXN2L

3.78e-031941123308_UP
DrugEtanidazole [22668-01-5]; Down 200; 18.6uM; MCF7; HT_HG-U133A

ACACB TMPRSS2

3.78e-031941126072_DN
DrugEthamivan [304-84-7]; Down 200; 18uM; HL60; HG-U133A

SS18 DENND4A

3.78e-031941121730_DN
DrugCP-645525-01 [287190-82-3]; Up 200; 10uM; PC3; HT_HG-U133A

GATA3 TMPRSS2

3.78e-031941127527_UP
DrugMianserine hydrochloride [21535-47-7]; Up 200; 13.2uM; PC3; HT_HG-U133A

SS18 DENND4A

3.78e-031941122068_UP
DrugAcyclovir [59277-89-3]; Down 200; 17.8uM; MCF7; HT_HG-U133A

ACACB TMPRSS2

3.78e-031941125278_DN
DrugAztreonam [78110-38-0]; Down 200; 9.2uM; PC3; HT_HG-U133A

ACACB SS18

3.78e-031941122118_DN
DrugFenspiride hydrochloride [5053-08-7]; Down 200; 13.4uM; PC3; HT_HG-U133A

GATA3 SS18

3.78e-031941122106_DN
Drugprazosin hydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A_EA

TMPRSS2 ATXN2L

3.78e-03194112942_UP
DrugBAS 012416453; Down 200; 38uM; PC3; HT_HG-U133A

ACACB DENND4A

3.78e-031941126876_DN
DrugPilocarpine nitrate [148-72-1]; Up 200; 14.8uM; PC3; HT_HG-U133A

GATA3 TMPRSS2

3.78e-031941126741_UP
Drugsemustine; Down 200; 100uM; PC3; HT_HG-U133A

ACACB GATA3

3.78e-031941127545_DN
DrugFlumequine [42835-25-6]; Down 200; 15.4uM; PC3; HT_HG-U133A

GATA3 SS18

3.78e-031941125104_DN
Diseaseintelligence, self reported educational attainment

ATXN2L DENND4A

5.51e-0411792EFO_0004337, EFO_0004784
Diseaseamino acid measurement

CDK8 ACACB TMPRSS2

9.15e-0467893EFO_0005134
DiseaseAlzheimer disease, educational attainment

ATXN2L DENND4A

2.42e-0324792EFO_0011015, MONDO_0004975
Diseasealcohol consumption measurement

CDK8 ACACB ATXN2L

5.16e-03124293EFO_0007878
Diseasetestosterone measurement

SS18 ATXN2L DENND4A

5.56e-03127593EFO_0004908
Diseasecognitive function measurement

SS18 ATXN2L DENND4A

7.72e-03143493EFO_0008354
Diseaseinflammatory bowel disease

SHC1 ATXN2L

7.75e-0344992EFO_0003767
Diseaseneutrophil percentage of leukocytes

GATA3 DENND4A

1.40e-0261092EFO_0007990

Protein segments in the cluster

PeptideGeneStartEntry
YPYIGHPQGEQPGQA

ATXN2L

1021

Q8WWM7
PNGEEPPLQYSYNGF

DENND4A

686

Q7Z401
YNYNPFEGPNDHPEG

RIMBP3B

841

A6NNM3
YNYNPFEGPNDHPEG

RIMBP3C

841

A6NJZ7
HYVPVPGGPNNNNYA

ACACB

316

O00763
QGPYNEYEPTHEGPF

LRRTM2

481

O43300
FNIDGQGNHVPPYYG

GATA3

51

P23771
DYQRSNPHAAYPNPG

CDK8

421

P49336
YNYNPFEGPNDHPEG

RIMBP3

841

Q9UFD9
IGPYYENHGYQPENP

TMPRSS2

11

O15393
ENHGYQPENPYPAQP

TMPRSS2

16

O15393
GPPEGMNQQYYPDGH

SS18

281

Q15532
DGYPENFQGVYHPGD

TEX13C

296

A0A0J9YWL9
EEEPPDHQYYNDFPG

SHC1

341

P29353