Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cytoskeletal motor activity	MYH1 MYH2 MYH4 MYH8 DNAH12 KIF3B DYNC2H1 KIF3C	5.55e-08	118	89	8	GO:0003774
GeneOntologyMolecularFunction	microfilament motor activity	MYH1 MYH2 MYH4 MYH8	2.42e-05	38	89	4	GO:0000146
GeneOntologyMolecularFunction	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity	CHSY1 CHSY3	1.17e-04	4	89	2	GO:0050510
GeneOntologyMolecularFunction	microtubule motor activity	DNAH12 KIF3B DYNC2H1 KIF3C	2.70e-04	70	89	4	GO:0003777
GeneOntologyMolecularFunction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity	CHSY1 CHSY3	2.91e-04	6	89	2	GO:0047238
GeneOntologyMolecularFunction	cytoskeletal protein binding	MYH1 MYH2 MYH4 MYH8 KIF3B ARHGEF7 TTLL4 CKAP5 DPYSL4 SPIRE1 KIF3C REEP4 ALDOB NOD2	3.44e-04	1099	89	14	GO:0008092
GeneOntologyBiologicalProcess	muscle filament sliding	MYH2 MYH4 MYH8	3.29e-05	15	88	3	GO:0030049
GeneOntologyBiologicalProcess	positive regulation of transforming growth factor beta2 production	BMPR1A ATF2	5.38e-05	3	88	2	GO:0032915
GeneOntologyBiologicalProcess	actin-myosin filament sliding	MYH2 MYH4 MYH8	5.85e-05	18	88	3	GO:0033275
GeneOntologyCellularComponent	muscle myosin complex	MYH1 MYH2 MYH4 MYH8	5.13e-07	16	88	4	GO:0005859
GeneOntologyCellularComponent	myosin filament	MYH1 MYH2 MYH4 MYH8	3.47e-06	25	88	4	GO:0032982
GeneOntologyCellularComponent	myosin II complex	MYH1 MYH2 MYH4 MYH8	5.56e-06	28	88	4	GO:0016460
GeneOntologyCellularComponent	myosin complex	MYH1 MYH2 MYH4 MYH8	1.12e-04	59	88	4	GO:0016459
GeneOntologyCellularComponent	clathrin-sculpted glutamate transport vesicle membrane	OTOF SLC17A8	6.19e-04	9	88	2	GO:0060203
GeneOntologyCellularComponent	clathrin-sculpted glutamate transport vesicle	OTOF SLC17A8	6.19e-04	9	88	2	GO:0060199
GeneOntologyCellularComponent	neuronal ribonucleoprotein granule	CKAP5 KIF3C	7.71e-04	10	88	2	GO:0071598
GeneOntologyCellularComponent	cytoplasmic region	DNAH12 KIF3B DYNC2H1 CANX RIMS3 CKAP5 KIF3C	8.14e-04	360	88	7	GO:0099568
GeneOntologyCellularComponent	cytoplasmic ribonucleoprotein granule	MYH1 ZFP36L1 NYNRIN CKAP5 KIF3C TDRD6	9.64e-04	269	88	6	GO:0036464
GeneOntologyCellularComponent	ciliary tip	KIF3B DYNC2H1 KIF3C	1.09e-03	48	88	3	GO:0097542
GeneOntologyCellularComponent	neuron projection cytoplasm	KIF3B CANX CKAP5 KIF3C	1.21e-03	110	88	4	GO:0120111
GeneOntologyCellularComponent	ribonucleoprotein granule	MYH1 ZFP36L1 NYNRIN CKAP5 KIF3C TDRD6	1.34e-03	287	88	6	GO:0035770
Domain	Myosin_N	MYH1 MYH2 MYH4 MYH8	4.77e-07	15	83	4	PF02736
Domain	Myosin_N	MYH1 MYH2 MYH4 MYH8	4.77e-07	15	83	4	IPR004009
Domain	Myosin_tail_1	MYH1 MYH2 MYH4 MYH8	1.06e-06	18	83	4	PF01576
Domain	Myosin_tail	MYH1 MYH2 MYH4 MYH8	1.06e-06	18	83	4	IPR002928
Domain	Myosin-like_IQ_dom	MYH1 MYH2 MYH4 MYH8	1.34e-06	19	83	4	IPR027401
Domain	-	MYH1 MYH2 MYH4 MYH8	1.34e-06	19	83	4	4.10.270.10
Domain	Myosin_head_motor_dom	MYH1 MYH2 MYH4 MYH8	2.39e-05	38	83	4	IPR001609
Domain	MYOSIN_MOTOR	MYH1 MYH2 MYH4 MYH8	2.39e-05	38	83	4	PS51456
Domain	Myosin_head	MYH1 MYH2 MYH4 MYH8	2.39e-05	38	83	4	PF00063
Domain	MYSc	MYH1 MYH2 MYH4 MYH8	2.39e-05	38	83	4	SM00242
Domain	IQ	MYH1 MYH2 MYH4 MYH8 LRRIQ3	3.02e-05	81	83	5	SM00015
Domain	IQ_motif_EF-hand-BS	MYH1 MYH2 MYH4 MYH8 LRRIQ3	5.02e-05	90	83	5	IPR000048
Domain	IQ	MYH1 MYH2 MYH4 MYH8 LRRIQ3	5.87e-05	93	83	5	PS50096
Domain	IQ	MYH1 MYH2 MYH4 MYH8	2.81e-04	71	83	4	PF00612
Domain	Chond_GalNAc	CHSY1 CHSY3	5.37e-04	8	83	2	IPR008428
Domain	CHGN	CHSY1 CHSY3	5.37e-04	8	83	2	PF05679
Domain	MACPF	BRINP3 ASTN2	1.05e-03	11	83	2	PF01823
Domain	MACPF	BRINP3 ASTN2	1.25e-03	12	83	2	SM00457
Domain	MACPF	BRINP3 ASTN2	1.25e-03	12	83	2	IPR020864
Domain	Dynein_heavy_chain_D4_dom	DNAH12 DYNC2H1	1.72e-03	14	83	2	IPR024317
Domain	Dynein_heavy_dom-2	DNAH12 DYNC2H1	1.72e-03	14	83	2	IPR013602
Domain	DHC_N2	DNAH12 DYNC2H1	1.72e-03	14	83	2	PF08393
Domain	AAA_8	DNAH12 DYNC2H1	1.72e-03	14	83	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH12 DYNC2H1	1.72e-03	14	83	2	IPR011704
Domain	AAA_5	DNAH12 DYNC2H1	1.72e-03	14	83	2	PF07728
Domain	DHC_fam	DNAH12 DYNC2H1	1.97e-03	15	83	2	IPR026983
Domain	Dynein_heavy_dom	DNAH12 DYNC2H1	1.97e-03	15	83	2	IPR004273
Domain	Dynein_heavy	DNAH12 DYNC2H1	1.97e-03	15	83	2	PF03028
Domain	P-loop_NTPase	MYH1 MYH2 MYH4 MYH8 DNAH12 KIF3B DYNC2H1 N4BP2L2 KIF3C NOD2	4.28e-03	848	83	10	IPR027417
Domain	cEGF	THBD LRP2	5.92e-03	26	83	2	IPR026823
Domain	cEGF	THBD LRP2	5.92e-03	26	83	2	PF12662
Pubmed	Sequential accumulation of mRNAs encoding different myosin heavy chain isoforms during skeletal muscle development in vivo detected with a recombinant plasmid identified as coding for an adult fast myosin heavy chain from mouse skeletal muscle.	MYH1 MYH2 MYH4 MYH8	2.00e-10	5	89	4	6196357
Pubmed	Developmental pattern of mouse skeletal myosin heavy chain gene transcripts in vivo and in vitro.	MYH1 MYH2 MYH4 MYH8	2.00e-10	5	89	4	3829126
Pubmed	Myosin heavy chain isoforms of the murine masseter muscle during pre- and post-natal development.	MYH1 MYH2 MYH4 MYH8	2.00e-10	5	89	4	12919077
Pubmed	Distinct myogenic programs of embryonic and fetal mouse muscle cells: expression of the perinatal myosin heavy chain isoform in vitro.	MYH1 MYH2 MYH4 MYH8	5.99e-10	6	89	4	1728586
Pubmed	Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.	MYH1 MYH2 MYH4 MYH8	5.99e-10	6	89	4	10077619
Pubmed	Spatial and temporal changes in myosin heavy chain gene expression in skeletal muscle development.	MYH1 MYH2 MYH4 MYH8	5.99e-10	6	89	4	10588881
Pubmed	A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes.	MYH1 MYH2 MYH4 MYH8	1.39e-09	7	89	4	35210422
Pubmed	Diversity in transcriptional start site selection and alternative splicing affects the 5'-UTR of mouse striated muscle myosin transcripts.	MYH1 MYH2 MYH4 MYH8	1.39e-09	7	89	4	16819597
Pubmed	Modulation of contractile protein gene expression in fetal murine crural muscles: emergence of muscle diversity.	MYH1 MYH2 MYH4 MYH8	1.30e-08	11	89	4	8136524
Pubmed	Transition of myosin heavy chain isoforms in human laryngeal abductors following denervation.	MYH1 MYH2 MYH4	1.62e-08	3	89	3	26059207
Pubmed	Contractile protein gene expression in primary myotubes of embryonic mouse hindlimb muscles.	MYH1 MYH2 MYH4 MYH8	2.81e-08	13	89	4	8404542
Pubmed	Defective excitation-contraction coupling is partially responsible for impaired contractility in hindlimb muscles of Stac3 knockout mice.	MYH1 MYH2 MYH4 MYH8	3.93e-08	14	89	4	27184118
Pubmed	Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity.	MYH1 MYH2 MYH4	6.47e-08	4	89	3	10388558
Pubmed	Evaluation of embryonic and perinatal myosin gene mutations and the etiology of congenital idiopathic clubfoot.	MYH1 MYH2 MYH8	6.47e-08	4	89	3	20357587
Pubmed	A human YAC transgene rescues craniofacial and neural tube development in PDGFRalpha knockout mice and uncovers a role for PDGFRalpha in prenatal lung growth.	MYH1 MYH2 MYH4	6.47e-08	4	89	3	11023856
Pubmed	Three linked myosin heavy chain genes clustered within 370 kb of each other show independent transcriptional and post-transcriptional regulation during differentiation of a mouse muscle cell line.	MYH1 MYH4 MYH8	6.47e-08	4	89	3	1985022
Pubmed	Smooth muscle myosin light chain kinase expression in cardiac and skeletal muscle.	MYH1 MYH2 MYH4	6.47e-08	4	89	3	11029314
Pubmed	Modulation of skeletal muscle fiber type by mitogen-activated protein kinase signaling.	MYH1 MYH2 MYH4	6.47e-08	4	89	3	18417546
Pubmed	Detection of Gene and Protein Expression in Mouse Embryos and Tissue Sections.	MYH1 MYH2 MYH4	1.61e-07	5	89	3	30737693
Pubmed	A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis.	MYH1 MYH2 MYH4 MYH8	2.83e-07	22	89	4	24301466
Pubmed	A hypoplastic model of skeletal muscle development displaying reduced foetal myoblast cell numbers, increased oxidative myofibres and improved specific tension capacity.	MYH1 MYH2 MYH4	3.22e-07	6	89	3	20417199
Pubmed	A role for Insulin-like growth factor 2 in specification of the fast skeletal muscle fibre.	MYH1 MYH2 MYH4	3.22e-07	6	89	3	17559643
Pubmed	ANKK1 is found in myogenic precursors and muscle fibers subtypes with glycolytic metabolism.	MYH1 MYH2 MYH4	5.63e-07	7	89	3	29758057
Pubmed	Neuromuscular junction immaturity and muscle atrophy are hallmarks of the ColQ-deficient mouse, a model of congenital myasthenic syndrome with acetylcholinesterase deficiency.	MYH1 MYH2 MYH4	8.99e-07	8	89	3	26993635
Pubmed	Genes for skeletal muscle myosin heavy chains are clustered and are not located on the same mouse chromosome as a cardiac myosin heavy chain gene.	MYH1 MYH4 MYH8	8.99e-07	8	89	3	3864153
Pubmed	Cell lineage- and expression-based inference of the roles of forkhead box transcription factor Foxc2 in craniofacial development.	MYH1 MYH2 MYH4	8.99e-07	8	89	3	33667029
Pubmed	A Tcf4-positive mesodermal population provides a prepattern for vertebrate limb muscle patterning.	MYH1 MYH2 MYH4	8.99e-07	8	89	3	14667415
Pubmed	GASP-2 overexpressing mice exhibit a hypermuscular phenotype with contrasting molecular effects compared to GASP-1 transgenics.	MYH1 MYH2 MYH4	1.35e-06	9	89	3	31960486
Pubmed	Myosin heavy chain-embryonic regulates skeletal muscle differentiation during mammalian development.	MYH1 MYH2 MYH4 MYH8	1.55e-06	33	89	4	32094117
Pubmed	During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation.	MYH1 MYH4 MYH8	1.92e-06	10	89	3	19506036
Pubmed	Acceleration of somitic myogenesis in embryos of myogenin promoter-MRF4 transgenic mice.	MYH1 MYH2 MYH8	1.92e-06	10	89	3	8950513
Pubmed	Extracellular matrix protein composition dynamically changes during murine forelimb development.	MYH1 MYH2 MYH4	2.63e-06	11	89	3	38303699
Pubmed	Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle.	MYH1 MYH2 MYH4	2.63e-06	11	89	3	18310078
Pubmed	The histone code reader Spin1 controls skeletal muscle development.	MYH1 MYH2 MYH4	2.63e-06	11	89	3	29168801
Pubmed	Calcineurin is necessary for the maintenance but not embryonic development of slow muscle fibers.	MYH1 MYH2 MYH4	2.63e-06	11	89	3	16024798
Pubmed	Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease.	MYH1 MYH2 MYH4 MYH8	3.08e-06	39	89	4	38690566
Pubmed	The inhibition of differentiation caused by TGFbeta in fetal myoblasts is dependent upon selective expression of PKCtheta: a possible molecular basis for myoblast diversification during limb histogenesis.	MYH1 MYH2 MYH8	4.55e-06	13	89	3	8948582
Pubmed	Loss of Prox1 in striated muscle causes slow to fast skeletal muscle fiber conversion and dilated cardiomyopathy.	MYH1 MYH2 MYH4	5.78e-06	14	89	3	24938781
Pubmed	Myopathy associated LDB3 mutation causes Z-disc disassembly and protein aggregation through PKCα and TSC2-mTOR downregulation.	MYH1 MYH2 MYH4	5.78e-06	14	89	3	33742095
Pubmed	HOXA5 plays tissue-specific roles in the developing respiratory system.	MYH1 MYH2 MYH4 MYH8	6.02e-06	46	89	4	28827394
Pubmed	Myosin heavy chains IIa and IId are functionally distinct in the mouse.	MYH1 MYH2	6.48e-06	2	89	2	9585413
Pubmed	Synaptic activity is not required for establishing heterogeneity of inner hair cell ribbon synapses.	OTOF SLC17A8	6.48e-06	2	89	2	37745283
Pubmed	Analysis of mouse conceptuses with uniparental duplication/deficiency for distal chromosome 12: comparison with chromosome 12 uniparental disomy and implications for genomic imprinting.	MYH1 MYH2	6.48e-06	2	89	2	16575183
Pubmed	Five skeletal myosin heavy chain genes are organized as a multigene complex in the human genome.	MYH4 MYH8	6.48e-06	2	89	2	8518795
Pubmed	Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle.	MYH1 MYH2	6.48e-06	2	89	2	7545970
Pubmed	Growth and muscle defects in mice lacking adult myosin heavy chain genes.	MYH1 MYH4	6.48e-06	2	89	2	9382868
Pubmed	Postnatal myosin heavy chain isoform expression in normal mice and mice null for IIb or IId myosin heavy chains.	MYH1 MYH4	6.48e-06	2	89	2	11150240
Pubmed	TFIIH contains a PH domain involved in DNA nucleotide excision repair.	GTF2H1 ERCC5	6.48e-06	2	89	2	15195146
Pubmed	Myosin heavy chain composition of the human genioglossus muscle.	MYH1 MYH2	6.48e-06	2	89	2	22337492
Pubmed	Glutamate co-release at GABA/glycinergic synapses is crucial for the refinement of an inhibitory map.	OTOF SLC17A8	6.48e-06	2	89	2	20081852
Pubmed	Chondroitin sulfate synthase-3. Molecular cloning and characterization.	CHSY1 CHSY3	6.48e-06	2	89	2	12907687
Pubmed	Temporal spatial expression and function of non-muscle myosin II isoforms IIA and IIB in scar remodeling.	MYH2 MYH4	6.48e-06	2	89	2	21102503
Pubmed	Different pathways regulate expression of the skeletal myosin heavy chain genes.	MYH1 MYH2	6.48e-06	2	89	2	11551968
Pubmed	Skeletal muscle adaptations in response to voluntary wheel running in myosin heavy chain null mice.	MYH1 MYH4	6.48e-06	2	89	2	11744674
Pubmed	Six homeoproteins and a Iinc-RNA at the fast MYH locus lock fast myofiber terminal phenotype.	MYH1 MYH2 MYH4	7.21e-06	15	89	3	24852826
Pubmed	MusTRD can regulate postnatal fiber-specific expression.	MYH1 MYH2 MYH4	8.86e-06	16	89	3	16494860
Pubmed	A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance.	MYH1 MYH2 MYH4	8.86e-06	16	89	3	19922871
Pubmed	Slow and fast fiber isoform gene expression is systematically altered in skeletal muscle of the Sox6 mutant, p100H.	MYH2 MYH4 MYH8	1.07e-05	17	89	3	16124007
Pubmed	IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolism.	MYH1 MYH2 MYH4	1.07e-05	17	89	3	22351927
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	RLF ZNF644 CKAP5 LRP2 ZMYM2 PSMD1 PLEKHA5 PCM1	1.23e-05	418	89	8	34709266
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	FSIP2 ZFP36L1 AASS RABGAP1L HJURP CKAP5 SPIRE1 PLEKHA5 REEP4 MLXIP PCM1	1.27e-05	861	89	11	36931259
Pubmed	Neuron-specific antioxidant OXR1 extends survival of a mouse model of amyotrophic lateral sclerosis.	MYH1 MYH2 MYH4	1.29e-05	18	89	3	25753484
Pubmed	Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression.	MYH1 MYH2 MYH4 MYH8	1.53e-05	58	89	4	21884692
Pubmed	The dynamics of thrombin formation.	THBD F13B	1.94e-05	3	89	2	12524220
Pubmed	Simultaneous loss of skeletal muscle myosin heavy chain IIx and IIb causes severe skeletal muscle hypoplasia in postnatal mice.	MYH1 MYH4	1.94e-05	3	89	2	36515178
Pubmed	Structural and developmental analysis of two linked myosin heavy chain genes.	MYH1 MYH2	1.94e-05	3	89	2	1371481
Pubmed	Chondroitin synthase-3 regulates nucleus pulposus degeneration through actin-induced YAP signaling.	CHSY1 CHSY3	1.94e-05	3	89	2	33089528
Pubmed	Kinesin-2 KIF3AC and KIF3AB Can Drive Long-Range Transport along Microtubules.	KIF3B KIF3C	1.94e-05	3	89	2	26445448
Pubmed	Heterodimerization of Kinesin-2 KIF3AB Modulates Entry into the Processive Run.	KIF3B KIF3C	1.94e-05	3	89	2	27637334
Pubmed	Maximum velocity of shortening in relation to myosin isoform composition in single fibres from human skeletal muscles.	MYH2 MYH4	1.94e-05	3	89	2	8145163
Pubmed	Molecular determinants of force production in human skeletal muscle fibers: effects of myosin isoform expression and cross-sectional area.	MYH1 MYH2	1.94e-05	3	89	2	25567808
Pubmed	Expression of KIF3C kinesin during neural development and in vitro neuronal differentiation.	KIF3B KIF3C	1.94e-05	3	89	2	11331403
Pubmed	Mammalian cells express three distinct dynein heavy chains that are localized to different cytoplasmic organelles.	DNAH12 DYNC2H1	1.94e-05	3	89	2	8666668
Pubmed	ZEB1 imposes a temporary stage-dependent inhibition of muscle gene expression and differentiation via CtBP-mediated transcriptional repression.	MYH2 MYH4	1.94e-05	3	89	2	23339872
Pubmed	The myosin alkali light chain proteins and their genes.	MYH2 MYH4	1.94e-05	3	89	2	3904738
Pubmed	Kinesin-2 and photoreceptor cell death: requirement of motor subunits.	KIF3B KIF3C	1.94e-05	3	89	2	16337628
Pubmed	Nonsense in the testis: multiple roles for nonsense-mediated decay revealed in male reproduction.	PLEKHA5 TDRD6	1.94e-05	3	89	2	28444146
Pubmed	The expression of myosin heavy chain (MHC) genes in human skeletal muscle is related to metabolic characteristics involved in the pathogenesis of type 2 diabetes.	MYH1 MYH2	1.94e-05	3	89	2	21470888
Pubmed	Specific isomyosin proportions in hyperexcitable and physiologically denervated mouse muscle.	MYH2 MYH4	1.94e-05	3	89	2	15013776
Pubmed	Several dual specificity phosphatases coordinate to control the magnitude and duration of JNK activation in signaling response to oxidative stress.	DUSP10 ATF2	1.94e-05	3	89	2	17681939
Pubmed	JNK-ATF-2 inhibits thrombomodulin (TM) expression by recruiting histone deacetylase4 (HDAC4) and forming a transcriptional repression complex in the TM promoter.	THBD ATF2	3.87e-05	4	89	2	20116378
Pubmed	Response Element Composition Governs Correlations between Binding Site Affinity and Transcription in Glucocorticoid Receptor Feed-forward Loops.	AASS KLF15	3.87e-05	4	89	2	26088140
Pubmed	Control of muscle formation by the fusogenic micropeptide myomixer.	MYH1 MYH2	3.87e-05	4	89	2	28386024
Pubmed	Deficiency of Myo18B in mice results in embryonic lethality with cardiac myofibrillar aberrations.	MYH1 MYH2	3.87e-05	4	89	2	18761673
Pubmed	Chondroitin synthases I, II, III and chondroitin sulfate glucuronyltransferase expression in colorectal cancer.	CHSY1 CHSY3	3.87e-05	4	89	2	21468578
Pubmed	Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation.	MYH1 MYH4	3.87e-05	4	89	2	12547197
Pubmed	Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing.	OTOF SLC17A8	3.87e-05	4	89	2	27458190
Pubmed	Synemin acts as a regulator of signalling molecules during skeletal muscle hypertrophy.	MYH2 MYH4 MYH8	5.07e-05	28	89	3	25179606
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	RLF USP42 CNEP1R1 ZNF644 CANX HJURP CKAP5 ZMYM2 PSMD1 REEP4 PRPF8 STT3B	5.66e-05	1203	89	12	29180619
Pubmed	Cullin-3-RING ubiquitin ligase activity is required for striated muscle function in mice.	MYH1 MYH2	6.44e-05	5	89	2	29653945
Pubmed	Changes in vitamin D target gene expression in adipose tissue monitor the vitamin D response of human individuals.	THBD DUSP10	6.44e-05	5	89	2	24975273
Pubmed	Multigene family for sarcomeric myosin heavy chain in mouse and human DNA: localization on a single chromosome.	MYH1 MYH2	6.44e-05	5	89	2	6879174
Pubmed	Sox6 is required for normal fiber type differentiation of fetal skeletal muscle in mice.	MYH1 MYH2	6.44e-05	5	89	2	17584907
Pubmed	Autophagy controls neonatal myogenesis by regulating the GH-IGF1 system through a NFE2L2- and DDIT3-mediated mechanism.	MYH1 MYH2 MYH4	6.91e-05	31	89	3	30081710
Pubmed	Genome-wide mapping of Sox6 binding sites in skeletal muscle reveals both direct and indirect regulation of muscle terminal differentiation by Sox6.	MYH1 MYH2 MYH4	6.91e-05	31	89	3	21985497
Pubmed	HOXA5 Participates in Brown Adipose Tissue and Epaxial Skeletal Muscle Patterning and in Brown Adipocyte Differentiation.	MYH2 MYH4 MYH8	7.61e-05	32	89	3	33732701
Pubmed	A small family of sushi-class retrotransposon-derived genes in mammals and their relation to genomic imprinting.	NYNRIN RTL9	9.65e-05	6	89	2	16155747
Pubmed	A hypomorphic myogenin allele reveals distinct myogenin expression levels required for viability, skeletal muscle development, and sternum formation.	MYH4 MYH8	1.35e-04	7	89	2	10075840
Pubmed	Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage.	CHSY1 CHSY3	1.35e-04	7	89	2	17145758
Pubmed	Hox11-expressing interstitial cells contribute to adult skeletal muscle at homeostasis.	MYH1 MYH2	1.35e-04	7	89	2	36815629
Interaction	RSPH6A interactions	MYH1 MYH2 MYH4 MYH8	1.30e-05	34	86	4	int:RSPH6A
Interaction	ZSCAN5A interactions	MYH1 MYH4 MYH8 ZMYM2	2.04e-05	38	86	4	int:ZSCAN5A
Interaction	TMEM260 interactions	MYH1 MYH4 CANX	2.08e-05	13	86	3	int:TMEM260
Cytoband	10q23-q25	SORCS3 IDE	2.22e-05	4	89	2	10q23-q25
Cytoband	17p13.1	MYH1 MYH2 MYH4 MYH8	8.55e-05	118	89	4	17p13.1
Cytoband	Ensembl 112 genes in cytogenetic band chr17p13	MYH1 MYH2 MYH4 MYH8 PRPF8	5.84e-04	346	89	5	chr17p13
GeneFamily	Myosin heavy chains	MYH1 MYH2 MYH4 MYH8	1.27e-07	15	58	4	1098
GeneFamily	Beta 4-glycosyltransferases	CHSY1 CHSY3	1.33e-03	17	58	2	425
Coexpression	HUMMERICH_BENIGN_SKIN_TUMOR_DN	MYH1 MYH2 MYH4 MYH8	5.77e-07	20	89	4	M1123
Coexpression	HUMMERICH_BENIGN_SKIN_TUMOR_DN	MYH1 MYH2 MYH4 MYH8	7.11e-07	21	89	4	MM1102
Coexpression	LAKE_ADULT_KIDNEY_C3_PROXIMAL_TUBULE_EPITHELIAL_CELLS_S1_S2	PPP1R21 RABGAP1L LRP2 N4BP2L2 ASTN2 PLEKHA5 ALDOB SDK1	8.84e-07	221	89	8	M39222
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MYH1 MYH2 MYH4 MYH8 LRP2 ASTN2	9.68e-07	164	89	6	382e42701779d12a7948690b3be72d06dd75c8b4
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l21\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LETM2 TTLL4 ZMYM2 DUSP10 PRPF8	1.24e-05	149	89	5	65778f19599b4955c0a16f0121237656449431fb
ToppCell	Thalamus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a7-Tac2-Excitatory_Neuron.Slc17a7.Tac2.Syt15_(Medial_habenula)\|Thalamus / BrainAtlas - Mouse McCarroll V32	MYH1 MYH2 MYH4 SLC17A8	1.73e-05	77	89	4	7f624e9262bd0dc2ac4176f43c91a4bc0f521fe5
ToppCell	severe-unassigned\|severe / disease stage, cell group and cell class	LETM2 ZNF175 TTLL4 PLEKHA5 KIF3C	2.02e-05	165	89	5	f9ddd547992fec065d539a1d0305acba8fc7d79c
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-K_cells_(GIP+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYH1 MYH4 MYH8 BRINP3 DNAH12	2.61e-05	174	89	5	3503c7dec498597f76a86dbd5e4bb2311e743bde
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS3 ZFP36L1 AASS KLF15 SLC38A3	2.68e-05	175	89	5	3f1b2e23fec953148fb0711e523c463adb07dca4
ToppCell	facs-Pancreas-Exocrine-18m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRSS3 ZFP36L1 AASS KLF15 SLC38A3	2.99e-05	179	89	5	bbfbfb32773346080127055b5aafa36bbf7d0942
ToppCell	facs-Pancreas-Exocrine-24m\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYH4 PRSS3 LRP2 ALDOB SLC38A3	3.07e-05	180	89	5	72310baeed848f2c483ae986cd73d2fb2cca7feb
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZNF670 OTOF GGCT RIMS3 TOP1MT	3.15e-05	181	89	5	c8286a7ac8e3cc5aa7e92b043a08435294ea686f
ToppCell	droplet-Kidney-nan-18m\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CMIP CANX LRP2 ALDOB F13B	3.40e-05	184	89	5	e02859bbac36dbbd55d7ae8cb5e46b764d7c6381
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Dendritic\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZNF670 OTOF GGCT RIMS3 TOP1MT	3.49e-05	185	89	5	405bd4ba7ca7f7b625c49f1313ff946509e17c13
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Myeloid-Dendritic-conventional_dendritic_cell\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ZNF670 OTOF GGCT RIMS3 TOP1MT	3.49e-05	185	89	5	2aa5e9f6f167d27317a01d22392b59512333fa64
ToppCell	COVID-19_Convalescent-Classical_Monocyte-cMono_3\|Classical_Monocyte / Disease condition and Cell class	THBD USP42 PLCXD1 DHRS11 HCFC2	3.87e-05	189	89	5	8b6f92ccfffc743c07201bc971b3dc1a6fa14ccc
ToppCell	COVID-19_Convalescent-Classical_Monocyte-cMono_3\|COVID-19_Convalescent / Disease condition and Cell class	THBD USP42 PLCXD1 DHRS11 HCFC2	3.87e-05	189	89	5	732e8dcffcb634ca2968f9170c9c4b31dd5d4206
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	OTOF SLC17A8 ASTN2 DUSP10 CCDC136	4.17e-05	192	89	5	dc40ef2341e5d6a6d479f140e023fe1bf687928d
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	CMIP RABGAP1L LRP2 PLEKHA5 SDK1	4.17e-05	192	89	5	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	OTOF SLC17A8 ASTN2 DUSP10 CCDC136	4.27e-05	193	89	5	2189da4b727e25e62669d7b9257f06493be21a27
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	OTOF SLC17A8 ASTN2 DUSP10 CCDC136	5.06e-05	200	89	5	347a510755374c6a66acee326565dfc447993f18
ToppCell	Parenchymal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ASPN ZNF175 CKAP5 KLF15 CHSY3	5.06e-05	200	89	5	a372ef3f9e6ff6e3c3376d6e10182977c5067788
Drug	oxovanadium	MYH1 MYH2 MYH4 THBD MYH8 CANX	6.74e-06	120	87	6	CID000024411
Drug	Mephenytoin [50-12-4]; Down 200; 18.4uM; MCF7; HT_HG-U133A	ARHGEF7 DHRS11 TTLL4 DPYSL4 ASTN2 DUSP10 ZC3H3	1.06e-05	197	87	7	6275_DN
Drug	Dimenhydrinate [523-87-5]; Up 200; 8.6uM; MCF7; HT_HG-U133A	THBD ZFP36L1 ZMYM2 N4BP2L2 ASTN2 KIF3C PCM1	1.10e-05	198	87	7	7431_UP
Disease	dilated cardiomyopathy 1S (implicated_via_orthology)	MYH1 MYH2 MYH4 MYH8	1.46e-08	10	87	4	DOID:0110454 (implicated_via_orthology)
Disease	autosomal dominant hyaline body myopathy (implicated_via_orthology)	MYH1 MYH2 MYH4 MYH8	1.46e-08	10	87	4	DOID:0111269 (implicated_via_orthology)
Disease	congenital myopathy 6 (implicated_via_orthology)	MYH1 MYH2 MYH4 MYH8	1.46e-08	10	87	4	DOID:0080719 (implicated_via_orthology)
Disease	distal arthrogryposis type 2B3 (implicated_via_orthology)	MYH1 MYH2 MYH4 MYH8	1.46e-08	10	87	4	DOID:0111602 (implicated_via_orthology)
Disease	inclusion body myositis (implicated_via_orthology)	MYH1 MYH2 MYH4 MYH8	1.46e-08	10	87	4	DOID:3429 (implicated_via_orthology)
Disease	distal arthrogryposis type 2A (implicated_via_orthology)	MYH1 MYH2 MYH4 MYH8	1.46e-08	10	87	4	DOID:0111605 (implicated_via_orthology)
Disease	familial hypertrophic cardiomyopathy (implicated_via_orthology)	MYH1 MYH2 MYH4 MYH8	1.46e-08	10	87	4	DOID:0080326 (implicated_via_orthology)
Disease	distal arthrogryposis type 1 (implicated_via_orthology)	MYH1 MYH2 MYH4 MYH8	1.46e-08	10	87	4	DOID:0111596 (implicated_via_orthology)
Disease	distal myopathy (implicated_via_orthology)	MYH1 MYH2 MYH4 MYH8	3.43e-08	12	87	4	DOID:11720 (implicated_via_orthology)
Disease	myotonia congenita (implicated_via_orthology)	MYH1 MYH2 MYH4 MYH8	3.43e-08	12	87	4	DOID:2106 (implicated_via_orthology)
Disease	restrictive cardiomyopathy (implicated_via_orthology)	MYH1 MYH2 MYH4 MYH8	4.94e-08	13	87	4	DOID:397 (implicated_via_orthology)
Disease	distal arthrogryposis (implicated_via_orthology)	MYH1 MYH2 MYH4 MYH8	9.39e-08	15	87	4	DOID:0050646 (implicated_via_orthology)
Disease	cardiomyopathy (implicated_via_orthology)	MYH1 MYH2 MYH4 MYH8 KLF15	2.22e-06	71	87	5	DOID:0050700 (implicated_via_orthology)
Disease	myopathy (implicated_via_orthology)	MYH1 MYH2 MYH4 MYH8	1.24e-05	48	87	4	DOID:423 (implicated_via_orthology)
Disease	intestinal disease (is_implicated_in)	BMPR1A NOD2	2.57e-05	3	87	2	DOID:5295 (is_implicated_in)
Disease	congenital heart disease (implicated_via_orthology)	USP42 LRP2 HCFC2 NAA16	5.27e-05	69	87	4	DOID:1682 (implicated_via_orthology)
Disease	chordin-like protein 1 measurement	ARHGEF7 RTL9	8.54e-05	5	87	2	EFO_0020257
Disease	dilated cardiomyopathy (implicated_via_orthology)	MYH1 MYH2 MYH4 MYH8	9.40e-05	80	87	4	DOID:12930 (implicated_via_orthology)
Disease	larynx cancer (is_implicated_in)	ERCC5 NOD2	1.28e-04	6	87	2	DOID:2596 (is_implicated_in)
Disease	childhood trauma measurement	BRINP3 SORCS3	2.27e-03	24	87	2	EFO_0007979
Disease	urate measurement, bone density	FSIP2 BMPR1A RABGAP1L PRSS55 SLC17A8 FADS2B SLC38A3	2.37e-03	619	87	7	EFO_0003923, EFO_0004531
Disease	multisite chronic pain	SORCS3 ASTN2 SDK1	2.82e-03	95	87	3	EFO_0010100

Protein segments in the cluster

Peptide	Gene	Start	Entry
AKLPNTMDYDTTKLC	BRINP3	751	Q76B58
CYNTKPGASRTMKIE	ELMOD1	41	Q8N336
PNMVTAGHACTKKYT	ALDOB	231	P05062
GKKYNINPVSMDICK	AASS	521	Q9UDR5
MGSCYKTKKFLLSLA	CMIP	551	Q8IY22
KDCPVTAMQKKSGYH	ATF2	416	P15336
ALCYKEDLSKSPKTM	ARHGEF7	666	Q14155
DFCPTVPKMKKSLYS	ASPN	331	Q9BXN1
YKLAPDGKSCLMLSD	ASTN2	741	O75129
KLHQKYCLKSPGQMT	HJURP	586	Q8NCD3
TCMKNYESKKYSDPS	LETM2	46	Q2VYF4
VIYCKKDSGSPKMYV	HCFC2	196	Q9Y5Z7
AFDYQSKMLALKCPS	LSM12	31	Q3MHD2
YPNDLAKKMTKCSKS	DUSP10	151	Q9Y6W6
MELYLGACSKPAKVA	FSIP2	1	Q5CZC0
SSQMKKRPTSAVGYK	KIF3C	671	O14782
KYPLCTRKESKGMCT	F13B	511	P05160
CMFPKATDTSFKNKL	MYH8	541	P13535
GNCPTKKYMPAVTST	PCM1	781	Q15154
CMFPKATDTSFKNKL	MYH2	541	Q9UKX2
YKNGLKFCKMILSNP	NAA16	26	Q6N069
MKFCAKDPKVLAATS	DNAH12	946	Q6ZR08
SFKALSICKKMSGPL	LY75	616	O60449
SPQYKKIICMGAKEN	GGCT	136	O75223
CMFPKATDTSFKNKL	MYH1	541	P12882
TGKYCEMAFSKGISP	LRP2	4406	P98164
PLSAECMLQYKKKAA	PPP1R21	511	Q6ZMI0
IPGSHDTMTYCLNKK	PLCXD1	41	Q9NUJ7
FNKLTYLGCMKVSSP	RABGAP1L	131	Q5R372
NGKCSTPRKSLSMYT	FADS2B	46	A8MWK0
MLKSCFPESLKVYGA	GLYATL3	16	Q5SZD4
ECMTLAYSGKLVSPK	MLXIP	131	Q9HAP2
LCKTGKVVKQYTMNP	DYNC2H1	1996	Q8NCM8
ANCPLYVTKVMSKGA	DPYSL4	246	O14531
YEKMAKATGKLKPTS	CKAP5	1051	Q14008
NGKGIKPKCSSEMYE	CPNE4	536	Q96A23
MKYEGSDFQCKDSPK	BMPR1A	101	P36894
KKQTSGMEYKKTDAP	CANX	506	P27824
PGCSKMYTKSSHLKA	KLF15	326	Q9UIH9
LCGFQKKTYSKMNNP	IDE	31	P14735
KKMPNCSPTAKNAVY	GRAMD2A	276	Q8IUY3
KAAATYEQMKCLKPE	DHRS11	216	Q6UWP2
KKYKNCSTGKGISTM	SDK1	2036	Q7Z5N4
DDKKYTSMKESTNCP	OTOF	281	Q9HC10
NMGKAKEYLKGLCSP	NYNRIN	61	Q9P2P1
KLGCIYPSSLMKAFA	NYNRIN	1871	Q9P2P1
MLCPAYASYKAVKTK	REEP4	16	Q9H6H4
CKLIYDSMALGNPGK	RIN3	766	Q8TB24
NKKDKTMSYGGCVAQ	OR2G6	86	Q5TZ20
KLKKSQCTPLFMNAY	APIP	91	Q96GX9
KYTSKENCNGKMATL	MRPL3	131	P09001
KQYKRATASGKMSTP	RTL9	486	Q8NET4
YCQDTRKGMKEPTKL	FAM47E	161	Q6ZV65
ARAKMEYKCAAPSKE	THBD	546	P07204
SCMEGKSFLQKSPSK	SLC38A3	41	Q99624
NMKLPCTEYLSKSVG	TDRD6	1186	O60522
TKMTKKTCDPLYQQA	RIMS3	211	Q9UJD0
REKYTAKAQMCPGKA	SORCS3	806	Q9UPU3
GMSFDVKSSPCEKLK	ERCC5	316	P28715
KMPKVQYKSNCKPST	PSMD1	796	Q99460
CMFPKATDTSFKNKL	MYH4	541	Q9Y623
GIPASKVHNYCNMKK	WT1-AS	21	Q06250
YNMSCDDTGKLILKP	CNEP1R1	106	Q8N9A8
KSYGSMVPSNENCRK	CCDC136	746	Q96JN2
DPKQYKMCLGSKAST	CHSY1	756	Q86X52
NLDPKQYKMCLGSKA	CHSY3	841	Q70JA7
QAMEYKKKHSSPCAI	C10orf120	121	Q5SQS8
PRKSYKMNSSCADIL	PRPF8	1616	Q6P2Q9
MYADIKCQKISPEGK	GTF2H1	46	P32780
VLCKGNKMLNYSAPS	ZFP36L1	16	Q07352
ENSYKCSKCKKMVPA	USP42	286	Q9H9J4
VSKEKMPVCSYFLKG	ZC3H3	721	Q8IXZ2
CRKEPKLLMSVYSSG	TRAV12-1	61	A0A0B4J245
ALPLEAATCKKYMAK	NOD2	211	Q9HC29
KVFGPSSLKEKCSSM	RLF	931	Q13129
CRPMNGKEKAASYDK	KIF3B	16	O15066
KAGSPTLLNCLMYKM	STT3B	706	Q8TCJ2
QCCKKMRLPSKPYST	SPIRE1	621	Q08AE8
KYIMLNPCSKLKGET	TOP1MT	261	Q969P6
FPKLTKNMLCAGYKN	PRSS55	226	Q6UWB4
AECKASYPGKITNSM	PRSS3	226	P35030
LCKPLTMTKATYCKP	ZMYM2	851	Q9UBW7
KKSATYICKMCPFTT	ZNF644	581	Q9H582
MIGSKPFSTVKYKNE	PLEKHA5	786	Q9HAU0
SCKYSPSMKSLGNKF	TTLL4	791	Q14679
KCGKAFMPQLKLSVY	ZNF175	311	Q9Y473
SPKKKMSYGATSQNC	SLC17A8	541	Q8NDX2
MPQSTYTGEKTYKCK	ZNF670	186	Q9BS34
ALTMFDCPVSLKKGY	LRRIQ3	126	A6PVS8
KKDLSNKAMPSHCDY	N4BP2L2	221	Q92802