Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	fatty-acyl-CoA synthase activity	ACSM4 ACSM3 ACSM2A ACSM2B	1.83e-08	8	82	4	GO:0004321
GeneOntologyMolecularFunction	medium-chain fatty acid-CoA ligase activity	ACSM4 ACSM3 ACSM2A ACSM2B	8.53e-08	11	82	4	GO:0031956
GeneOntologyMolecularFunction	decanoate-CoA ligase activity	ACSM4 ACSM2A ACSM2B	2.66e-07	4	82	3	GO:0102391
GeneOntologyMolecularFunction	ligase activity, forming carbon-sulfur bonds	ACSM4 ACSM3 NAE1 ACSM2A ACSM2B	6.89e-07	41	82	5	GO:0016877
GeneOntologyMolecularFunction	C-acyltransferase activity	ACSM4 ACSM3 ACSM2A ACSM2B	1.50e-06	21	82	4	GO:0016408
GeneOntologyMolecularFunction	fatty acid ligase activity	ACSM4 ACSM3 ACSM2A ACSM2B	3.69e-06	26	82	4	GO:0015645
GeneOntologyMolecularFunction	CoA-ligase activity	ACSM4 ACSM3 ACSM2A ACSM2B	4.31e-06	27	82	4	GO:0016405
GeneOntologyMolecularFunction	acid-thiol ligase activity	ACSM4 ACSM3 ACSM2A ACSM2B	7.64e-06	31	82	4	GO:0016878
GeneOntologyMolecularFunction	benzoate-CoA ligase activity	ACSM2A ACSM2B	4.98e-05	3	82	2	GO:0018858
GeneOntologyMolecularFunction	acyltransferase activity, transferring groups other than amino-acyl groups	ELOVL4 KAT2B ACSM4 ACSM3 ACSM2A PRDX6 ACSM2B	5.57e-05	238	82	7	GO:0016747
GeneOntologyMolecularFunction	acyltransferase activity	ELOVL4 KAT2B ACSM4 ACSM3 CBLL2 UFL1 RNF122 ZBED1 ACSM2A PRDX6 ACSM2B	3.18e-04	775	82	11	GO:0016746
GeneOntologyMolecularFunction	ligase activity	ACSM4 ACSM3 NAE1 ACSM2A ACSM2B	7.53e-04	174	82	5	GO:0016874
Domain	AMP-bd_C	ACSM4 ACSM3 ACSM2A ACSM2B	7.48e-07	17	81	4	IPR025110
Domain	AMP-binding_C	ACSM4 ACSM3 ACSM2A ACSM2B	7.48e-07	17	81	4	PF13193
Domain	AMP-binding_CS	ACSM4 ACSM3 ACSM2A ACSM2B	4.56e-06	26	81	4	IPR020845
Domain	AMP_BINDING	ACSM4 ACSM3 ACSM2A ACSM2B	6.21e-06	28	81	4	PS00455
Domain	AMP-binding	ACSM4 ACSM3 ACSM2A ACSM2B	8.26e-06	30	81	4	PF00501
Domain	AMP-dep_Synth/Lig	ACSM4 ACSM3 ACSM2A ACSM2B	8.26e-06	30	81	4	IPR000873
Domain	ZF_BED	ZBED1 ZBED5	2.76e-04	6	81	2	PS50808
Domain	zf-BED	ZBED1 ZBED5	2.76e-04	6	81	2	PF02892
Domain	PAK_BD	PAK1 PAK2	2.76e-04	6	81	2	IPR033923
Domain	WASP_C	PAK1 PAK2	3.85e-04	7	81	2	IPR011026
Domain	-	PAK1 PAK2	1.19e-03	12	81	2	3.90.810.10
Domain	Znf_BED	ZBED1 ZBED5	1.19e-03	12	81	2	IPR003656
Domain	PBD	PAK1 PAK2	2.14e-03	16	81	2	SM00285
Domain	PBD	PAK1 PAK2	2.42e-03	17	81	2	PF00786
Domain	CRIB	PAK1 PAK2	3.36e-03	20	81	2	PS50108
Domain	CRIB_dom	PAK1 PAK2	3.70e-03	21	81	2	IPR000095
Domain	DEP	PLEK2 PREX1	4.06e-03	22	81	2	PF00610
Domain	DEP	PLEK2 PREX1	4.06e-03	22	81	2	PS50186
Domain	DEP	PLEK2 PREX1	4.06e-03	22	81	2	SM00049
Domain	DEP_dom	PLEK2 PREX1	4.43e-03	23	81	2	IPR000591
Domain	WD40	WDR20 PWP2 WDR82 TBL2 BRWD3	5.37e-03	259	81	5	PF00400
Domain	WD40_repeat_CS	PWP2 WDR82 TBL2 BRWD3	5.64e-03	164	81	4	IPR019775
Domain	G-protein_beta_WD-40_rep	PWP2 WDR82 TBL2	6.01e-03	85	81	3	IPR020472
Domain	WD40	WDR20 PWP2 WDR82 TBL2 BRWD3	6.19e-03	268	81	5	SM00320
Domain	WD40_repeat	WDR20 PWP2 WDR82 TBL2 BRWD3	6.58e-03	272	81	5	IPR001680
Domain	WD_REPEATS_1	WDR20 PWP2 WDR82 TBL2 BRWD3	7.20e-03	278	81	5	PS00678
Domain	WD_REPEATS_2	WDR20 PWP2 WDR82 TBL2 BRWD3	7.31e-03	279	81	5	PS50082
Domain	WD_REPEATS_REGION	WDR20 PWP2 WDR82 TBL2 BRWD3	7.31e-03	279	81	5	PS50294
Pathway	REACTOME_CONJUGATION_OF_SALICYLATE_WITH_GLYCINE	ACSM4 ACSM2A ACSM2B	1.61e-06	6	62	3	MM14693
Pathway	REACTOME_AMINO_ACID_CONJUGATION	ACSM4 ACSM2A ACSM2B	2.80e-06	7	62	3	MM14598
Pathway	REACTOME_AMINO_ACID_CONJUGATION	ACSM4 ACSM2A ACSM2B	6.68e-06	9	62	3	M26968
Pathway	REACTOME_SIGNAL_TRANSDUCTION_BY_L1	PAK1 FGFR1 ITGA9	7.47e-05	19	62	3	MM15113
Pathway	REACTOME_RHOJ_GTPASE_CYCLE	ARHGAP5 PAK1 PAK2 PREX1	9.78e-05	55	62	4	M41815
Pathway	REACTOME_SIGNAL_TRANSDUCTION_BY_L1	PAK1 FGFR1 ITGA9	1.02e-04	21	62	3	M878
Pathway	REACTOME_RHOQ_GTPASE_CYCLE	ARHGAP5 PAK1 PAK2 PREX1	1.20e-04	58	62	4	MM15602
Pathway	REACTOME_RHOQ_GTPASE_CYCLE	ARHGAP5 PAK1 PAK2 PREX1	1.29e-04	59	62	4	M41812
Pathway	REACTOME_MUSCLE_CONTRACTION	KAT2B MYH8 PAK1 PAK2 NEB TBX5	2.60e-04	203	62	6	M5485
Pathway	KEGG_BUTANOATE_METABOLISM	ACSM4 ACSM3 ACSM2A	4.40e-04	34	62	3	M3397
Pathway	REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION	KAT2B TBX5	5.24e-04	8	62	2	MM14816
Pathway	REACTOME_RAC3_GTPASE_CYCLE	ARHGAP5 PAK1 PAK2 PREX1	7.39e-04	93	62	4	MM15609
Pathway	REACTOME_RAC3_GTPASE_CYCLE	ARHGAP5 PAK1 PAK2 PREX1	7.69e-04	94	62	4	M41818
Pathway	REACTOME_ASPIRIN_ADME	ACSM4 ACSM2A ACSM2B	9.44e-04	44	62	3	M45014
Pathway	REACTOME_ASPIRIN_ADME	ACSM4 ACSM2A ACSM2B	1.01e-03	45	62	3	MM15694
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	RPL34 RPF2 CSTF3 SRP14 WDR82 TFIP11 MPHOSPH10 MRPL9 GRSF1 TOP1 TBL2	9.31e-07	713	82	11	29802200
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	PLEK2 MYH8 RPL34 ACSM3 RAPH1 SETD5 RPF2 PWP2 SRP14 AK1 FGFR1 MPHOSPH10 NEB PREX1 TOP1	1.25e-06	1442	82	15	35575683
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	MCPH1 ERV3-1 SETD5 HYKK RPF2 TTC21B GPR137B CSTF3 ANKRD12 ZNF839 GRHL2 CASZ1 VPS13B BRWD3 PRDX6	1.86e-06	1489	82	15	28611215
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	SETD5 WDR20 RPF2 PWP2 CSTF3 WDR82 UFL1 TFIP11 CLDN3 MPHOSPH10 PREX1 MRPL9 GRSF1 TBL2 CASZ1	1.98e-06	1497	82	15	31527615
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	ARHGAP5 RPL34 RPF2 PWP2 CSTF3 SRP14 WDR82 TFIP11 MPHOSPH10 TOP1 TBL2	4.86e-06	847	82	11	35850772
Pubmed	Thin filament length in the cardiac sarcomere varies with sarcomere length but is independent of titin and nebulin.	NEB RBM20	5.49e-06	2	82	2	27139341
Pubmed	Activation of PAK1/2 during the shedding of platelet microvesicles.	PAK1 PAK2	5.49e-06	2	82	2	20523167
Pubmed	The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population.	ACSM2A ACSM2B	5.49e-06	2	82	2	16521160
Pubmed	PAK1, PAK1Δ15, and PAK2: similarities, differences and mutual interactions.	PAK1 PAK2	5.49e-06	2	82	2	31748572
Pubmed	Alphaherpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by group A p21-activated kinases.	PAK1 PAK2	5.49e-06	2	82	2	19435845
Pubmed	Constitutive p21-activated kinase (PAK) activation in breast cancer cells as a result of mislocalization of PAK to focal adhesions.	PAK1 PAK2	5.49e-06	2	82	2	15047871
Pubmed	Comparative analyses of disease risk genes belonging to the acyl-CoA synthetase medium-chain (ACSM) family in human liver and cell lines.	ACSM2A ACSM2B	5.49e-06	2	82	2	19634011
Pubmed	Analyses of the genetic diversity and protein expression variation of the acyl: CoA medium-chain ligases, ACSM2A and ACSM2B.	ACSM2A ACSM2B	5.49e-06	2	82	2	29948332
Pubmed	The p21-activated kinase 2 (PAK2), but not PAK1, regulates contraction-stimulated skeletal muscle glucose transport.	PAK1 PAK2	5.49e-06	2	82	2	32597567
Pubmed	The subcellular localization of type I p21-activated kinases is controlled by the disordered variable region and polybasic sequences.	PAK1 PAK2	5.49e-06	2	82	2	31391252
Pubmed	PAK1 and PAK2 in cell metabolism regulation.	PAK1 PAK2	5.49e-06	2	82	2	34750857
Pubmed	Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells.	PAK1 PAK2	5.49e-06	2	82	2	9395435
Pubmed	Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms.	PAK1 PAK2	5.49e-06	2	82	2	18411304
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	PLEK2 RPL34 RPF2 PWP2 PAK2 SRP14 WDR82 UFL1 TFIP11 MPHOSPH10 GRSF1 TOP1 PRDX6	1.23e-05	1318	82	13	30463901
Pubmed	Group I Paks Promote Skeletal Myoblast Differentiation In Vivo and In Vitro.	PAK1 PAK2	1.64e-05	3	82	2	27920252
Pubmed	Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation.	PAK1 PAK2	1.64e-05	3	82	2	10075701
Pubmed	Altered cortical synaptic morphology and impaired memory consolidation in forebrain- specific dominant-negative PAK transgenic mice.	PAK1 PAK2	1.64e-05	3	82	2	15182717
Pubmed	The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment.	PAK1 PAK2	1.64e-05	3	82	2	23335370
Pubmed	Group I Paks as therapeutic targets in NF2-deficient meningioma.	PAK1 PAK2	1.64e-05	3	82	2	25596744
Pubmed	Clathrin-independent endocytosis used by the IL-2 receptor is regulated by Rac1, Pak1 and Pak2.	PAK1 PAK2	1.64e-05	3	82	2	18344974
Pubmed	The four mammalian splice variants encoded by the p21-activated kinase 3 gene have different biological properties.	PAK1 PAK2	1.64e-05	3	82	2	18507705
Pubmed	Reducing RBM20 activity improves diastolic dysfunction and cardiac atrophy.	NEB RBM20	1.64e-05	3	82	2	27889803
Pubmed	Late-onset megaconial myopathy in mice lacking group I Paks.	PAK1 PAK2	1.64e-05	3	82	2	30791960
Pubmed	PAK1 and PAK2 have different roles in HGF-induced morphological responses.	PAK1 PAK2	1.64e-05	3	82	2	19628037
Pubmed	PAK1 inhibition reduces tumor size and extends the lifespan of mice in a genetically engineered mouse model of Neurofibromatosis Type 2 (NF2).	PAK1 PAK2	1.64e-05	3	82	2	34075397
Pubmed	Porocarcinomas with PAK1/2/3 fusions: a series of 12 cases.	PAK1 PAK2	1.64e-05	3	82	2	38785043
Pubmed	Protein kinase D1 (PKD1) phosphorylation on Ser203 by type I p21-activated kinase (PAK) regulates PKD1 localization.	PAK1 PAK2	1.64e-05	3	82	2	28408623
Pubmed	Pak1 and Pak2 are activated in recurrent respiratory papillomas, contributing to one pathway of Rac1-mediated COX-2 expression.	PAK1 PAK2	1.64e-05	3	82	2	20131316
Pubmed	Acetylation of TBX5 by KAT2B and KAT2A regulates heart and limb development.	KAT2B TBX5	1.64e-05	3	82	2	29174768
Pubmed	The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity.	PAK1 PAK2	1.64e-05	3	82	2	11278486
Pubmed	p21-Activated Kinases 1, 2 and 4 in Endometrial Cancers: Effects on Clinical Outcomes and Cell Proliferation.	PAK1 PAK2	1.64e-05	3	82	2	26218748
Pubmed	TXLNA enhances TBK1 phosphorylation by suppressing PPM1B recruitment.	RPL34 CSTF3 UFL1 TFIP11 TOP1	1.95e-05	138	82	5	37506885
Pubmed	Scrib regulates PAK activity during the cell migration process.	PAK1 PAK2	3.28e-05	4	82	2	18716323
Pubmed	Pak to the future.	PAK1 PAK2	3.28e-05	4	82	2	10461188
Pubmed	Grainyhead-like 2 regulates epithelial morphogenesis by establishing functional tight junctions through the organization of a molecular network among claudin3, claudin4, and Rab25.	CLDN3 GRHL2	3.28e-05	4	82	2	22696678
Pubmed	Expression of Acsm2, a kidney-specific gene, parallels the function and maturation of proximal tubular cells.	ACSM2A ACSM2B	3.28e-05	4	82	2	32830538
Pubmed	Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation.	PAK1 PAK2	3.28e-05	4	82	2	26078008
Pubmed	A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20.	PAK1 PAK2	3.28e-05	4	82	2	7744004
Pubmed	CHL1 cooperates with PAK1-3 to regulate morphological differentiation of embryonic cortical neurons.	PAK1 PAK2	3.28e-05	4	82	2	19819308
Pubmed	Regulation of the interaction of Pak2 with Cdc42 via autophosphorylation of serine 141.	PAK1 PAK2	3.28e-05	4	82	2	16204230
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	MYT1L ARHGAP5 SETD5 SH3GL3 TFIP11 ANKRD12 MPHOSPH10 ITGA9 RNF122 GRSF1 VPS13B	4.75e-05	1084	82	11	11544199
Pubmed	Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.	HYKK MAP3K13 TBX5	4.90e-05	30	82	3	22837378
Pubmed	Integrin linked kinase (ILK) is required for lens epithelial cell survival, proliferation and differentiation.	ARHGAP5 PAK1 ITGA9	4.90e-05	30	82	3	24472646
Pubmed	Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells.	PAK1 PAK2	5.47e-05	5	82	2	11956071
Pubmed	HGF and IGF-1 synergize with SDF-1α in promoting migration of myeloma cells by cooperative activation of p21-activated kinase.	PAK1 PAK2	5.47e-05	5	82	2	23499762
Pubmed	Nef as a Proliferative Factor for Kidney Epithelial Cells in HIV-Associated Nephropathy.	PAK1 PAK2	5.47e-05	5	82	2	21892329
Pubmed	A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC.	PAK1 PAK2	5.47e-05	5	82	2	15800193
Pubmed	TBL2 Associates With ATF4 mRNA Via Its WD40 Domain and Regulates Its Translation During ER Stress.	TOP1 TBL2	5.47e-05	5	82	2	26239904
Pubmed	Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486.	PAK1 PAK2	5.47e-05	5	82	2	23509247
Pubmed	Phosphorylation and reorganization of vimentin by p21-activated kinase (PAK).	PAK1 PAK2	5.47e-05	5	82	2	11895474
Pubmed	p21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 Pathway.	PAK1 PAK2	5.47e-05	5	82	2	26391956
Pubmed	Cdc42/Rac1-dependent activation of the p21-activated kinase (PAK) regulates human platelet lamellipodia spreading: implication of the cortical-actin binding protein cortactin.	PAK1 PAK2	5.47e-05	5	82	2	12453877
Pubmed	Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma.	RPL34 SRP14 WDR82 TFIP11 MAP3K13 MRPL9 GRSF1 TBL2 PRDX6	5.75e-05	732	82	9	34732716
Pubmed	Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin.	PAK1 PAK2	8.19e-05	6	82	2	12237306
Pubmed	Mice carrying a schizophrenia-associated mutation of the Arhgap10 gene are vulnerable to the effects of methamphetamine treatment on cognitive function: association with morphological abnormalities in striatal neurons.	PAK1 PAK2	8.19e-05	6	82	2	33482876
Pubmed	Pak1 is involved in dendrite initiation as a downstream effector of Rac1 in cortical neurons.	PAK1 PAK2	8.19e-05	6	82	2	12213441
Pubmed	Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism.	PAK1 FGFR1	8.19e-05	6	82	2	15548653
Pubmed	Endophilin, Lamellipodin, and Mena cooperate to regulate F-actin-dependent EGF-receptor endocytosis.	RAPH1 SH3GL3	8.19e-05	6	82	2	24076656
Pubmed	Targeted disruption of the gene for the PAK5 kinase in mice.	PAK1 PAK2	8.19e-05	6	82	2	14517284
Pubmed	HIV-1 Nef mediates Pak phosphorylation of Mek1 serine298 and elicits an active phospho-state of Pak2.	PAK1 PAK2	8.19e-05	6	82	2	23746211
Pubmed	Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.	RPL34 RPF2 PWP2 CSTF3 SRP14 WDR82 TMEM41B	1.01e-04	454	82	7	33226137
Pubmed	A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome.	KAT2B TBX5	1.14e-04	7	82	2	16332960
Pubmed	Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts.	ITGA9 TBX5	1.14e-04	7	82	2	23139255
Pubmed	VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin.	PAK1 PAK2	1.14e-04	7	82	2	17060906
Pubmed	A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.	ACSM4 MCPH1 NAE1 RPF2 TTC21B WWC1	1.35e-04	331	82	6	19490893
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	NAE1 PWP2 PAK2 CSTF3 SRP14 AK1 WDR82 UFL1 TOP1 PRDX6	1.36e-04	1014	82	10	32416067
Pubmed	NEDDylation controls the target specificity of E2F1 and apoptosis induction.	KAT2B MCPH1	1.52e-04	8	82	2	23001041
Pubmed	Skeletal muscle phenotypes initiated by ectopic MyoD in transgenic mouse heart.	MYH8 NEB	1.52e-04	8	82	2	1618148
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	RPF2 SRP14 WDR82 TFIP11 GRHL2 TOP1	1.59e-04	341	82	6	32971831
Pubmed	Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA.	PAK1 PAK2	1.96e-04	9	82	2	9535855
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	MYT1L ARHGAP5 RPRD1A ADNP2 PAK1 PAK2 TFIP11 PREX1 TOP1 BRWD3 ZBED5	2.13e-04	1285	82	11	35914814
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	PAK1 PAK2 GRHL2 GRSF1 RBM20 VPS13B PRDX6 METTL6	2.17e-04	686	82	8	29987050
Pubmed	ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions.	ZBED1 ZBED5	2.44e-04	10	82	2	23533661
Pubmed	HIV-1 Nef: a multifaceted modulator of T cell receptor signaling.	PAK1 PAK2	2.44e-04	10	82	2	23227982
Pubmed	Functional characterization of the human immunodeficiency virus type 1 Nef acidic domain.	PAK1 PAK2	2.44e-04	10	82	2	18653452
Pubmed	Disruption of planar cell polarity signaling results in congenital heart defects and cardiomyopathy attributable to early cardiomyocyte disorganization.	FGFR1 TBX5	2.98e-04	11	82	2	17556662
Pubmed	Cloning, central nervous system expression and chromosomal mapping of the mouse PAK-1 and PAK-3 genes.	PAK1 PAK2	2.98e-04	11	82	2	10352232
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	PLEK2 RPL34 PTPN12 RPF2 ADNP2 SRP14 WDR82 TFIP11 GRSF1 TOP1 ZBED5	3.30e-04	1353	82	11	29467282
Pubmed	Wnt signaling is required for organization of the lens fiber cell cytoskeleton and development of lens three-dimensional architecture.	PAK1 PAK2	3.57e-04	12	82	2	18824165
Pubmed	Frameshift variants in C10orf71 cause dilated cardiomyopathy in human, mouse, and organoid models.	RBM20 TBX5	3.57e-04	12	82	2	38950288
Pubmed	In-silico designing of a potent analogue against HIV-1 Nef protein and protease by predicting its interaction network with host cell proteins.	PAK1 PAK2	3.57e-04	12	82	2	23559827
Pubmed	Recapitulation of two genomewide association studies on blood pressure and essential hypertension in the Korean population.	ITGA9 TBX5	3.57e-04	12	82	2	20414254
Pubmed	HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases.	PAK1 PAK2	4.21e-04	13	82	2	23317503
Pubmed	Plexin signaling via off-track and rho family GTPases.	PAK1 PAK2	4.21e-04	13	82	2	11604131
Pubmed	Pax3 and Tbx5 specify whether PDGFRα+ cells assume skeletal or cardiac muscle fate in differentiating embryonic stem cells.	ADORA1 TBX5	4.21e-04	13	82	2	24677751
Pubmed	Blood pressure and hypertension are associated with 7 loci in the Japanese population.	ITGA9 CASZ1	4.21e-04	13	82	2	20479155
Pubmed	Loss of ARHGEF6 Causes Hair Cell Stereocilia Deficits and Hearing Loss in Mice.	PAK1 PAK2	4.21e-04	13	82	2	30333726
Pubmed	Genome-wide CRISPR-cas9 knockout screening identifies GRB7 as a driver for MEK inhibitor resistance in KRAS mutant colon cancer.	SRP14 TOP1 TBL2	4.53e-04	63	82	3	34718347
Pubmed	The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.	ARHGAP5 RPL34 MPHOSPH10 MRPL9 TOP1 TBL2	4.66e-04	417	82	6	36537216
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	KAT2B PWP2 CSTF3 SRP14 WDR82 TMEM41B GRSF1 TOP1 TBL2	4.70e-04	971	82	9	33306668
Pubmed	PAK is regulated by PI3K, PIX, CDC42, and PP2Calpha and mediates focal adhesion turnover in the hyperosmotic stress-induced p38 pathway.	PAK1 PAK2	4.91e-04	14	82	2	18586681
Pubmed	Mouse Twist is required for fibroblast growth factor-mediated epithelial-mesenchymal signalling and cell survival during limb morphogenesis.	FGFR1 TBX5	4.91e-04	14	82	2	12175489
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	RPL34 RPRD1A RPF2 PWP2 CSTF3 SRP14 UFL1 TDRD6 GRSF1 TOP1 PRDX6	5.10e-04	1425	82	11	30948266
Pubmed	Pharmacogenetic analysis of lipid responses to rosuvastatin in Chinese patients.	ACSM3 TBL2 ACSM2B	5.19e-04	66	82	3	20679960
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	RPL34 RPF2 PWP2 SRP14 PWWP3A TFIP11 MPHOSPH10 TOP1 PRDX6	5.37e-04	989	82	9	36424410
Interaction	ACSM2A interactions	ACSM3 ACSM2A ACSM2B	2.59e-07	4	82	3	int:ACSM2A
Cytoband	7q11.23	PTPN12 CLDN3 TBL2	7.17e-04	97	82	3	7q11.23
Cytoband	8q22.2	FBXO43 VPS13B	7.78e-04	23	82	2	8q22.2
Cytoband	Ensembl 112 genes in cytogenetic band chr20q12	EMILIN3 TOP1	9.96e-04	26	82	2	chr20q12
Cytoband	Ensembl 112 genes in cytogenetic band chr7q11	PTPN12 ERV3-1 CLDN3 TBL2	1.45e-03	271	82	4	chr7q11
Cytoband	16p12.3	ACSM2A ACSM2B	1.70e-03	34	82	2	16p12.3
Cytoband	8p12	FGFR1 RNF122	3.23e-03	47	82	2	8p12
Cytoband	Ensembl 112 genes in cytogenetic band chr8q22	FBXO43 GRHL2 VPS13B	3.45e-03	168	82	3	chr8q22
Cytoband	Ensembl 112 genes in cytogenetic band chr16p12	ACSM3 ACSM2A ACSM2B	3.68e-03	172	82	3	chr16p12
GeneFamily	Acyl-CoA synthetase family	ACSM4 ACSM3 ACSM2A ACSM2B	1.35e-06	26	58	4	40
GeneFamily	Zinc fingers BED-type\|Pseudoautosomal region 1	ZBED1 ZBED5	1.50e-04	6	58	2	64
GeneFamily	WD repeat domain containing	WDR20 PWP2 WDR82 TBL2 BRWD3	1.51e-03	262	58	5	362
Disease	X-21319 measurement	ACSM2A ACSM2B	6.72e-06	2	77	2	EFO_0800807
Disease	X-11478 measurement	ACSM2A ACSM2B	2.01e-05	3	77	2	EFO_0021242
Disease	emphysema imaging measurement	MYT1L HYKK ANKRD12 ZNF839 WWC1	4.11e-05	146	77	5	EFO_0007626
Disease	3-hydroxyhexanoate measurement	ACSM2A ACSM2B	6.69e-05	5	77	2	EFO_0800378
Disease	indoleacetylglutamine measurement	ACSM3 ACSM2A	1.00e-04	6	77	2	EFO_0800035
Disease	indoleacetoylcarnitine measurement	ACSM2A ACSM2B	1.00e-04	6	77	2	EFO_0800106
Disease	X-17676 measurement	ACSM3 ACSM2B	1.86e-04	8	77	2	EFO_0800785
Disease	insulin sensitivity measurement, glucose homeostasis measurement	MYT1L SETD5 PAK2	1.96e-04	43	77	3	EFO_0004471, EFO_0006896
Disease	creatinine measurement	SFMBT1 KAT2B PTPN12 ACSM3 GRK7 NEB GRHL2 CASZ1 BRWD3 ACSM2B	2.58e-04	995	77	10	EFO_0004518
Disease	Malignant neoplasm of breast	RPRD1A RAPH1 PAK1 FGFR1 MAP3K13 ITGA9 MRPL9 TOP1 VPS13B METTL6	4.70e-04	1074	77	10	C0006142
Disease	electrocardiography	SFMBT1 PTPN12 GRK7 FGFR1 RBM20 CASZ1 TBX5	4.71e-04	530	77	7	EFO_0004327
Disease	beta-hydroxyisovalerate measurement	ACSM3 ACSM2B	5.99e-04	14	77	2	EFO_0800125
Disease	Paroxysmal atrial fibrillation	PAK2 RBM20 CASZ1 TBX5	7.54e-04	156	77	4	C0235480
Disease	familial atrial fibrillation	PAK2 RBM20 CASZ1 TBX5	7.54e-04	156	77	4	C3468561
Disease	Persistent atrial fibrillation	PAK2 RBM20 CASZ1 TBX5	7.54e-04	156	77	4	C2585653
Disease	Atrial Fibrillation	PAK2 RBM20 CASZ1 TBX5	8.28e-04	160	77	4	C0004238
Disease	blood pressure	PREX1 BANK1	1.50e-03	22	77	2	EFO_0004325
Disease	health study participation	SFMBT1 FGFR1 BANK1 WWC1	1.72e-03	195	77	4	EFO_0010130
Disease	Neurodevelopmental Disorders	MYT1L SETD5 PAK1	1.87e-03	93	77	3	C1535926
Disease	response to venlafaxine	COL12A1 MCPH1	1.94e-03	25	77	2	EFO_0006328
Disease	urinary uromodulin measurement	ACSM3 ACSM2A ACSM2B	2.05e-03	96	77	3	EFO_0005663
Disease	unipolar depression, depressive symptom measurement	PLEK2 PREX1	2.10e-03	26	77	2	EFO_0003761, EFO_0007006
Disease	blood rubidium measurement	INSL6 PREX1	2.10e-03	26	77	2	EFO_0021529
Disease	mean arterial pressure, alcohol drinking	KAT2B BANK1 CASZ1	2.17e-03	98	77	3	EFO_0004329, EFO_0006340
Disease	urate measurement	SFMBT1 ACSM3 WDR20 WDR82 FGFR1 TOP1 TBL2 BANK1	2.31e-03	895	77	8	EFO_0004531
Disease	obesity (is_marker_for)	ADORA1 AK1 FGFR1	2.37e-03	101	77	3	DOID:9970 (is_marker_for)
Disease	tuberculosis	MYT1L RPRD1A GRHL2 VPS13B	2.49e-03	216	77	4	MONDO_0018076

Protein segments in the cluster

Peptide	Gene	Start	Entry
GKEPYTKKALKYFEE	TTC21B	156	Q7Z4L5
VKATTKIKYYPTAKA	BANK1	271	Q8NDB2
ALGYPIYDETKRKSK	ERV3-1	456	Q14264
IEGYPTYKEKVKKRP	BTBD10	371	Q9BSF8
DPQKYYGKELKIAKS	ADORA1	221	P30542
STYKKPSKYDLENVK	CASZ1	331	Q86V15
VKSVTAPYKYPRKIE	ACSM2A	531	Q08AH3
YTVEKKKKPSYTTQR	BRWD3	761	Q6RI45
KKSTAPYKYPRKVEF	ACSM4	541	P0C7M7
SYRTYSEKEGPEKKK	ANKRD12	96	Q6UB98
EGKYYSKGVKLVRKK	CBLL2	16	Q8N7E2
LDPKKYEGRSYEEKK	ADNP2	1041	Q6IQ32
EDGYYRKEPKAKSDK	RBM20	756	Q5T481
YYVPKGKAKVSRDLV	RAPH1	426	Q70E73
YKGKKIASFPTAKYI	GRSF1	336	Q12849
VIGPYSGKKKATVKY	MCPH1	796	Q8NEM0
IKIPKTKYVGYIKDY	KAT2B	626	Q92831
YKYLKKQSRELKPVG	WWC1	786	Q8IX03
YIRTYKEPKKPKAGK	ELOVL4	266	Q9GZR5
IKKRLETYYKATEPV	AK1	146	P00568
DKKKLERLYGRYKDP	DCUN1D2	61	Q6PH85
VYKPEVVAAYRGKKR	MYH8	136	P13535
SYVRETKGKLPSYKE	CSTF3	106	Q12996
KPKEDAYEYKKRLTL	MPHOSPH10	446	O00566
QDLKKKYYEEPRKGI	GBP1	441	P32455
AYEAPDKVRKYKKIV	MRO	76	Q9BYG7
TKKEKRTRIPYKPNY	OSBP	401	P22059
YKVLKPGKSVLFRDY	METTL6	176	Q8TCB7
IKREQAVEKKYPGTY	MAP3K13	501	O43283
VSVGDPKKKYTRFEK	PAK1	261	Q13153
KEYLGKKEKGPTLLY	FBXO43	91	Q4G163
AKGRTLIPCYEEYKK	ITGA9	171	Q13797
SIGDPKKKYTRYEKI	PAK2	241	Q13177
IKTFYDPETGKYVKV	CEFIP	1296	Q711Q0
YVSKTKDGPTEYVLK	HYKK	51	A2RU49
YGLPVEKIAKLYKKS	GRHL2	571	Q6ISB3
GKVRKYIVRYKTPEE	COL12A1	1591	Q99715
IDYYKKTTNGRLPVK	FGFR1	651	P11362
KLYKTYATKEGIPKS	GDF9	91	O60383
VLRPKYKVGYKTVTD	EMILIN3	101	Q9NT22
AGRTPFKDYKEKVSK	GRK7	386	Q8WTQ7
VYLYTKKVGKAPKSA	RPL34	31	P49207
FKAKSKYSPELLKYR	GPR137B	141	O60478
YKTAEEKYIKGPSLS	PWWP3A	676	Q2TAK8
EKYIKGPSLSYREKE	PWWP3A	681	Q2TAK8
EKYSKTGIKSALPYE	TDRD6	1696	O60522
LDYDYKKKRVGKIPD	SH3GL3	166	Q99963
SYKVKVTGLNPKTKY	TBX5	86	Q99593
YKDKKGYSPLGKTRE	INSL6	116	Q9Y581
VFTKELPSGKKYLRY	PRDX6	206	P30041
KNRIGGTYKKTIYKE	HEPH	66	Q9BQS7
KYRTEKIYPTATGEK	PTPN12	41	Q05209
TPVIKDRDYHLKTYK	PREX1	526	Q8TCU6
RAASKYPKTKKYLVT	SETD5	691	Q9C0A6
YIYKGVRKAADLSKP	WDR20	76	Q8TBZ3
GERRPSKYKYKSKTL	ARHGAP5	1146	Q13017
TKVLKDVYALKKPYG	RPF2	46	Q9H7B2
VKSVTAPYKYPRKIE	ACSM2B	531	Q68CK6
VKKTTAPYKYPRKVE	ACSM3	546	Q53FZ2
PREKKYTATKVVYSA	CLDN3	186	O15551
KTKADYVRPKLETYK	CLCA1	86	A8K7I4
SVVNFEKPKTKRYKY	MRPL9	236	Q9BYD2
YTFAESYKKKISPKE	PLEK2	221	Q9NYT0
QEGKPKRTLYSKKYG	WDR82	51	Q6UXN9
VYITLKKYDGRTKPI	SRP14	26	P37108
RYGYKEVVLKGDAKK	RNF122	71	Q9H9V4
KQALYGDKKPRKRTY	RPRD1A	126	Q96P16
DYKYRPRKKSKGAPA	SOX12	106	O15370
EEKTGKVKYSRLAKY	PWP2	266	Q15269
RVSRPPKYKAKDYKF	ZNF839	136	A8K0R7
FSKKPKRRKYDESYL	ZBED5	101	Q49AG3
PVSKYYRGKLSKPKI	VPS13B	2096	Q7Z7G8
GEVLKAKYKGKSYRA	SFMBT1	571	Q9UHJ3
GRPVVYKYLTEKAVK	TMEM41B	171	Q5BJD5
KYISTKAIPEKYGAV	ZBED1	166	O96006
YSETNGRIPKTYKEK	NAE1	226	Q13564
GKDSIRYYNKVPVEK	TOP1	531	P11387
EYKKKQDPYLLKTGR	TBL2	311	Q9Y4P3
GSKKKPKYSYKTVEE	TFIP11	231	Q9UBB9
PKYSYKTVEELKAKG	TFIP11	236	Q9UBB9
GIPDAVSYIKKRYKT	UFL1	276	O94874
PADIGYKIKTLIKKY	MX1	191	P20591
IGYKPEEYKLGKTKI	MYO1H	671	Q8N1T3
YYGKDPSRTEKKESK	MYT1L	491	Q9UL68
KLYKLGLEEAKRKGY	NEB	2756	P20929