Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionpotassium ion leak channel activity

KCNK2 KCNK4 KCNK10

5.11e-0616433GO:0022841
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

KCNK2 SLC17A7 SLC38A7 CACNA1C CNGA3 KCNK4 SLC22A3 KCNK10

5.77e-06465438GO:0046873
GeneOntologyMolecularFunctiongated channel activity

KCNK2 SLC17A7 CACNA1C TMC5 CNGA3 KCNK4 KCNK10

6.61e-06334437GO:0022836
GeneOntologyMolecularFunctionnarrow pore channel activity

KCNK2 KCNK4 KCNK10

8.80e-0619433GO:0022842
GeneOntologyMolecularFunctionleak channel activity

KCNK2 KCNK4 KCNK10

8.80e-0619433GO:0022840
GeneOntologyMolecularFunctiontransporter activity

KCNK2 SLC17A7 SLC38A7 CACNA1C ATP11A TMC5 RHBDF2 SLC17A9 CNGA3 KCNK4 SLC22A3 KCNK10

1.17e-0512894312GO:0005215
GeneOntologyMolecularFunctionoutward rectifier potassium channel activity

KCNK2 KCNK4 KCNK10

2.62e-0527433GO:0015271
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

KCNK2 SLC17A7 SLC38A7 CACNA1C TMC5 CNGA3 KCNK4 SLC22A3 KCNK10

3.93e-05793439GO:0015075
GeneOntologyMolecularFunctionacylglycerol O-acyltransferase activity

MOGAT3 AGPAT3 AGPAT4

4.42e-0532433GO:0016411
GeneOntologyMolecularFunctionmembrane potential driven uniporter activity

SLC17A7 SLC17A9

4.51e-055432GO:0022810
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

KCNK2 SLC17A7 SLC38A7 CACNA1C CNGA3 KCNK4 SLC22A3 KCNK10

4.96e-05627438GO:0022890
GeneOntologyMolecularFunctionmonoatomic ion channel activity

KCNK2 SLC17A7 CACNA1C TMC5 CNGA3 KCNK4 KCNK10

5.10e-05459437GO:0005216
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

KCNK2 SLC17A7 SLC38A7 CACNA1C CNGA3 KCNK4 SLC22A3 KCNK10

7.42e-05664438GO:0008324
GeneOntologyMolecularFunctionchannel activity

KCNK2 SLC17A7 CACNA1C TMC5 CNGA3 KCNK4 KCNK10

1.18e-04525437GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

KCNK2 SLC17A7 CACNA1C TMC5 CNGA3 KCNK4 KCNK10

1.20e-04526437GO:0022803
GeneOntologyMolecularFunctiontransmembrane transporter activity

KCNK2 SLC17A7 SLC38A7 CACNA1C TMC5 SLC17A9 CNGA3 KCNK4 SLC22A3 KCNK10

1.60e-0411804310GO:0022857
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

KCNK2 SLC17A7 SLC38A7 CACNA1C CNGA3 KCNK4 SLC22A3 KCNK10

1.85e-04758438GO:0015318
GeneOntologyMolecularFunctionuniporter activity

SLC17A7 SLC17A9

2.02e-0410432GO:0015292
GeneOntologyMolecularFunctionO-acyltransferase activity

MOGAT3 AGPAT3 AGPAT4

2.78e-0459433GO:0008374
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

KCNK2 CACNA1C KCNK4 KCNK10

3.16e-04152434GO:0022843
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

KCNK2 SLC17A7 KCNK4 KCNK10

4.52e-04167434GO:0015079
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC17A7 SLC38A7 CNGA3 SLC22A3

4.94e-04171434GO:0015081
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

KCNK2 CACNA1C KCNK4 KCNK10

6.24e-04182434GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

KCNK2 CACNA1C KCNK4 KCNK10

6.50e-04184434GO:0022832
GeneOntologyMolecularFunctionmechanosensitive monoatomic ion channel activity

TMC5 KCNK4

6.78e-0418432GO:0008381
GeneOntologyMolecularFunctionsolute:sodium symporter activity

SLC17A7 SLC38A7 SLC22A3

7.06e-0481433GO:0015370
GeneOntologyMolecularFunctionmonoatomic cation channel activity

KCNK2 CACNA1C CNGA3 KCNK4 KCNK10

8.18e-04343435GO:0005261
GeneOntologyMolecularFunction1-acylglycerol-3-phosphate O-acyltransferase activity

AGPAT3 AGPAT4

9.27e-0421432GO:0003841
GeneOntologyMolecularFunctionneurotransmitter transmembrane transporter activity

SLC17A7 SLC22A3

9.27e-0421432GO:0005326
GeneOntologyMolecularFunctionlysophosphatidic acid acyltransferase activity

AGPAT3 AGPAT4

1.21e-0324432GO:0042171
GeneOntologyMolecularFunctionlysophospholipid acyltransferase activity

AGPAT3 AGPAT4

1.21e-0324432GO:0071617
GeneOntologyMolecularFunctionvoltage-gated potassium channel activity

KCNK2 KCNK4 KCNK10

1.38e-03102433GO:0005249
GeneOntologyMolecularFunctionhydrolase activity, hydrolyzing O-glycosyl compounds

KL MAN1A2 ACER3

1.42e-03103433GO:0004553
GeneOntologyMolecularFunctionacyltransferase activity, transferring groups other than amino-acyl groups

ZDHHC20 MOGAT3 AGPAT3 AGPAT4

1.69e-03238434GO:0016747
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC17A7 SLC38A7 SLC22A3

2.14e-03119433GO:0015294
GeneOntologyMolecularFunctionacetylgalactosaminyltransferase activity

GALNT16 GBGT1

2.58e-0335432GO:0008376
GeneOntologyMolecularFunctionpotassium channel activity

KCNK2 KCNK4 KCNK10

2.63e-03128433GO:0005267
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

SLC17A7 SLC38A7 SLC17A9 SLC22A3

3.57e-03293434GO:0008514
GeneOntologyMolecularFunctionhydrolase activity, acting on glycosyl bonds

KL MAN1A2 ACER3

3.67e-03144433GO:0016798
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC17A7 SLC38A7 SLC17A9 SLC22A3

3.71e-03296434GO:0015291
GeneOntologyMolecularFunctionsymporter activity

SLC17A7 SLC38A7 SLC22A3

4.12e-03150433GO:0015293
GeneOntologyMolecularFunctiongrowth factor binding

KL RHBDF2 NTRK2

4.59e-03156433GO:0019838
GeneOntologyMolecularFunctionL-amino acid transmembrane transporter activity

SLC17A7 SLC38A7

1.02e-0271432GO:0015179
GeneOntologyBiologicalProcessstabilization of membrane potential

KCNK2 KCNK4 KCNK10

5.62e-0617433GO:0030322
GeneOntologyBiologicalProcessmemory

KCNK2 SLC17A7 KCNK4 NTRK2 KCNK10

3.81e-05183435GO:0007613
GeneOntologyBiologicalProcessneural retina development

SLC17A7 SDK2 CNGA3 NTRK2

6.00e-05102434GO:0003407
GeneOntologyBiologicalProcesslearning or memory

KCNK2 SLC17A7 CACNA1C KCNK4 NTRK2 KCNK10

1.16e-04373436GO:0007611
GeneOntologyBiologicalProcesscamera-type eye photoreceptor cell differentiation

SDK2 CNGA3 NTRK2

1.45e-0449433GO:0060219
GeneOntologyBiologicalProcesscognition

KCNK2 SLC17A7 CACNA1C KCNK4 NTRK2 KCNK10

2.30e-04423436GO:0050890
GeneOntologyBiologicalProcesscamera-type eye development

SLC17A7 CACNA1C OPN5 SDK2 CNGA3 NTRK2

2.39e-04426436GO:0043010
GeneOntologyBiologicalProcesslipid biosynthetic process

SCD5 PIGF ACER3 MOGAT3 GBGT1 AGPAT3 ABHD6 AGPAT4

2.40e-04813438GO:0008610
GeneOntologyBiologicalProcessglycerolipid metabolic process

SCD5 PIGF MOGAT3 AGPAT3 ABHD6 AGPAT4

2.48e-04429436GO:0046486
GeneOntologyBiologicalProcessCDP-diacylglycerol biosynthetic process

AGPAT3 AGPAT4

3.26e-0413432GO:0016024
GeneOntologyBiologicalProcessCDP-diacylglycerol metabolic process

AGPAT3 AGPAT4

3.80e-0414432GO:0046341
GeneOntologyBiologicalProcesseye development

SLC17A7 CACNA1C OPN5 SDK2 CNGA3 NTRK2

4.52e-04480436GO:0001654
GeneOntologyBiologicalProcesseye photoreceptor cell differentiation

SDK2 CNGA3 NTRK2

4.55e-0472433GO:0001754
GeneOntologyBiologicalProcessvisual system development

SLC17A7 CACNA1C OPN5 SDK2 CNGA3 NTRK2

4.67e-04483436GO:0150063
GeneOntologyBiologicalProcessmonoacylglycerol metabolic process

MOGAT3 ABHD6

5.00e-0416432GO:0046462
GeneOntologyBiologicalProcesssensory system development

SLC17A7 CACNA1C OPN5 SDK2 CNGA3 NTRK2

5.10e-04491436GO:0048880
GeneOntologyBiologicalProcesssensory organ development

KCNK2 SLC17A7 CACNA1C OPN5 SDK2 CNGA3 NTRK2

7.17e-04730437GO:0007423
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

KCNK2 ZDHHC20 ATP11A RNF175 SCD5 PIGF RHBDF2 ACER3 REEP3 MOGAT3 DIPK1A SLC22A3 AGPAT3 AGPAT4

2.21e-0713274314GO:0042175
GeneOntologyCellularComponentendoplasmic reticulum membrane

KCNK2 ZDHHC20 ATP11A RNF175 SCD5 PIGF RHBDF2 ACER3 REEP3 MOGAT3 DIPK1A AGPAT3 AGPAT4

1.17e-0612934313GO:0005789
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

KCNK2 ZDHHC20 ATP11A RNF175 SCD5 PIGF RHBDF2 ACER3 REEP3 MOGAT3 DIPK1A AGPAT3 AGPAT4

1.23e-0612994313GO:0098827
GeneOntologyCellularComponentmonoatomic ion channel complex

KCNK2 SLC17A7 CACNA1C CNGA3 KCNK4 ABHD6 KCNK10

1.10e-05378437GO:0034702
GeneOntologyCellularComponenttransporter complex

KCNK2 SLC17A7 CACNA1C ATP11A CNGA3 KCNK4 ABHD6 KCNK10

1.41e-05550438GO:1990351
GeneOntologyCellularComponenttransmembrane transporter complex

KCNK2 SLC17A7 CACNA1C CNGA3 KCNK4 ABHD6 KCNK10

8.70e-05523437GO:1902495
GeneOntologyCellularComponentGolgi membrane

ZDHHC20 RNF175 MAN1A2 ACER3 GALNT16 GBGT1 AGPAT3

6.16e-04721437GO:0000139
GeneOntologyCellularComponentcation channel complex

KCNK2 CACNA1C CNGA3 KCNK4

1.36e-03235434GO:0034703
GeneOntologyCellularComponentneuronal cell body

KCNK2 SLC38A7 CACNA1C INHA CNGA3 NTRK2 SLC22A3

1.45e-03835437GO:0043025
GeneOntologyCellularComponentcell body

KCNK2 SLC38A7 CACNA1C INHA CNGA3 NTRK2 SLC22A3

2.66e-03929437GO:0044297
GeneOntologyCellularComponentglial cell projection

KCNK2 CNGA3

4.21e-0347432GO:0097386
MousePhenoabnormal vision

SLC17A7 SCD5 CNGA3 NTRK2 AGPAT3

3.47e-0689375MP:0002090
MousePhenoabnormal mitral valve annulus morphology

KL MRGPRD

2.04e-053372MP:0010613
MousePhenoabnormal phospholipid level

ACER3 ACBD5 AGPAT3 AGPAT4

5.69e-0580374MP:0004777
MousePhenodecreased circulating hormone level

HELZ2 KL SCD5 SLC17A9 INHA GNRHR NTRK2 ABHD6

7.77e-05551378MP:0014457
MousePhenodecreased circulating follicle stimulating hormone level

INHA GNRHR NTRK2

9.65e-0534373MP:0002790
MousePhenodecreased hormone level

HELZ2 KL SCD5 SLC17A9 INHA GNRHR NTRK2 ABHD6

2.08e-04635378MP:0014455
MousePhenodecreased follicle stimulating hormone level

INHA GNRHR NTRK2

2.10e-0444373MP:0005130
Domain2pore_dom_K_chnl

KCNK2 KCNK4 KCNK10

5.07e-0615433IPR003280
Domain2pore_dom_K_chnl_TREK

KCNK2 KCNK10

5.18e-062432IPR003976
DomainK_chnl_dom

KCNK2 KCNK4 KCNK10

1.47e-0521433IPR013099
DomainIon_trans_2

KCNK2 KCNK4 KCNK10

1.47e-0521433PF07885
DomainAcyltransf_C

AGPAT3 AGPAT4

5.15e-055432PF16076
DomainAcyltransf_C

AGPAT3 AGPAT4

5.15e-055432IPR032098
DomainAcyltransferase

AGPAT3 AGPAT4

6.09e-0416432PF01553
DomainPlsC

AGPAT3 AGPAT4

6.89e-0417432SM00563
DomainSUGAR_TRANSPORT_2

SLC17A9 SLC22A3

6.89e-0417432PS00217
DomainPlipid/glycerol_acylTrfase

AGPAT3 AGPAT4

6.89e-0417432IPR002123
DomainMFS

SLC17A7 SLC17A9 SLC22A3

7.38e-0477433IPR011701
DomainMFS_1

SLC17A7 SLC17A9 SLC22A3

7.38e-0477433PF07690
DomainMFS

SLC17A7 SLC17A9 SLC22A3

1.96e-03108433PS50850
DomainSugar_transporter_CS

SLC17A9 SLC22A3

2.46e-0332432IPR005829
DomainMFS_dom

SLC17A7 SLC17A9 SLC22A3

3.61e-03134433IPR020846
Domain-

GALNT16 GBGT1

1.50e-02814323.90.550.10
DomainNucleotide-diphossugar_trans

GALNT16 GBGT1

1.75e-0288432IPR029044
PathwayREACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS

KCNK2 KCNK4 KCNK10

1.57e-0611313MM14547
PathwayREACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS

KCNK2 KCNK4 KCNK10

2.09e-0612313M1071
PathwayREACTOME_PHASE_4_RESTING_MEMBRANE_POTENTIAL

KCNK2 KCNK4 KCNK10

9.11e-0619313M27452
PathwayREACTOME_PHASE_4_RESTING_MEMBRANE_POTENTIAL

KCNK2 KCNK4 KCNK10

9.11e-0619313MM15194
PathwayWP_TRIACYLGLYCERIDE_SYNTHESIS

MOGAT3 AGPAT3 AGPAT4

1.89e-0524313M39692
PathwayREACTOME_CARDIAC_CONDUCTION

KCNK2 CACNA1C KCNK4 KCNK10

7.27e-05103314MM15196
PathwayREACTOME_CARDIAC_CONDUCTION

KCNK2 CACNA1C KCNK4 KCNK10

1.79e-04130314M27454
PathwayREACTOME_MUSCLE_CONTRACTION

KCNK2 CACNA1C KCNK4 KCNK10

4.45e-04165314MM15026
PathwayREACTOME_MUSCLE_CONTRACTION

KCNK2 CACNA1C KCNK4 KCNK10

9.69e-04203314M5485
PathwayREACTOME_METABOLISM_OF_LIPIDS

HELZ2 SCD5 ACER3 MOGAT3 ACBD5 AGPAT3 AGPAT4

1.06e-03757317M27451
PathwayWP_TRIACYLGLYCERIDE_SYNTHESIS

AGPAT3 AGPAT4

1.15e-0323312MM15890
PathwayREACTOME_POTASSIUM_CHANNELS

KCNK2 KCNK4 KCNK10

1.27e-0398313MM14545
PathwayREACTOME_POTASSIUM_CHANNELS

KCNK2 KCNK4 KCNK10

1.47e-03103313M1073
Pubmed

Behavioral characterization of mice lacking Trek channels.

KCNK2 KCNK4 KCNK10

1.76e-09343322973213
Pubmed

Mixing and matching TREK/TRAAK subunits generate heterodimeric K2P channels with unique properties.

KCNK2 KCNK4 KCNK10

1.76e-09343327035965
Pubmed

How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2.

KCNK2 KCNK4 KCNK10

1.76e-09343326332952
Pubmed

Role of the TREK2 potassium channel in cold and warm thermosensation and in pain perception.

KCNK2 KCNK4 KCNK10

1.76e-09343325239074
Pubmed

Lysophosphatidic acid-operated K+ channels.

KCNK2 KCNK4 KCNK10

1.76e-09343315572365
Pubmed

Tension activation of mechanosensitive two-pore domain K+ channels TRAAK, TREK-1, and TREK-2.

KCNK2 KCNK4 KCNK10

1.76e-09343338605031
Pubmed

Elevated expression of TREK-TRAAK K2P channels in the retina of adult rd1 mice.

KCNK2 KCNK4 KCNK10

7.04e-09443331236347
Pubmed

Glucose inhibition persists in hypothalamic neurons lacking tandem-pore K+ channels.

KCNK2 KCNK4 KCNK10

1.76e-08543319244527
Pubmed

K(+) efflux through two-pore domain K(+) channels is required for mouse embryonic development.

KCNK2 KCNK4 KCNK10

1.76e-08543322419831
Pubmed

Piezo1 and Piezo2 foster mechanical gating of K2P channels.

KCNK2 KCNK4 KCNK10

1.76e-08543334852225
Pubmed

Mechanoprotection by polycystins against apoptosis is mediated through the opening of stretch-activated K(2P) channels.

KCNK2 KCNK4 KCNK10

1.76e-08543322832196
Pubmed

Insights into the release mechanism of astrocytic glutamate evoking in neurons NMDA receptor-mediated slow depolarizing inward currents.

KCNK2 KCNK4 KCNK10

3.51e-08643330144319
Pubmed

Kv1.1 channels act as mechanical brake in the senses of touch and pain.

KCNK2 KCNK4 KCNK10

6.14e-08743323473320
Pubmed

Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins.

KCNK2 KCNK4 KCNK10

9.82e-08843328839101
Pubmed

Potassium leak channels and the KCNK family of two-P-domain subunits.

KCNK2 KCNK4 KCNK10

3.84e-071243311256078
Pubmed

International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels.

KCNK2 KCNK4 KCNK10

6.35e-071443316382106
Pubmed

Transcription factor short stature homeobox 2 is required for proper development of tropomyosin-related kinase B-expressing mechanosensory neurons.

SLC17A7 MRGPRD NTRK2

1.18e-061743321543603
Pubmed

Desensitization of mechano-gated K2P channels.

KCNK2 KCNK4

1.49e-06243216636285
Pubmed

Formation of Functional Heterodimers by TREK-1 and TREK-2 Two-pore Domain Potassium Channel Subunits.

KCNK2 KCNK10

1.49e-06243227129242
Pubmed

TREK-1, a K+ channel involved in neuroprotection and general anesthesia.

KCNK2 KCNK4

1.49e-06243215175651
Pubmed

AMP-activated protein kinase inhibits TREK channels.

KCNK2 KCNK10

1.49e-06243219840997
Pubmed

Expression of mechanogated two-pore domain potassium channels in mouse lungs: special reference to mechanosensory airway receptors.

KCNK2 KCNK4

1.49e-06243221822716
Pubmed

Modulation of K2P 2.1 and K2P 10.1 K(+) channel sensitivity to carvedilol by alternative mRNA translation initiation.

KCNK2 KCNK10

1.49e-06243225168769
Pubmed

Expression and effects of modulation of the K2P potassium channels TREK-1 (KCNK2) and TREK-2 (KCNK10) in the normal human ovary and epithelial ovarian cancer.

KCNK2 KCNK10

1.49e-06243223479219
Pubmed

Expression of stretch-activated two-pore potassium channels in human myometrium in pregnancy and labor.

KCNK2 KCNK4

1.49e-06243220811500
Pubmed

The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception.

KCNK2 KCNK4

1.49e-06243219279663
Pubmed

Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK.

KCNK2 KCNK10

1.49e-06243230573346
Pubmed

Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue.

KCNK2 KCNK10

1.49e-06243219667202
Pubmed

The glycine hinge of transmembrane segment 2 modulates the subcellular localization and gating properties in TREK channels.

KCNK2 KCNK10

1.49e-06243228676394
Pubmed

Genomic organization and chromosomal localization of the murine 2 P domain potassium channel gene Kcnk8: conservation of gene structure in 2 P domain potassium channels.

KCNK2 KCNK4

4.48e-06343211167025
Pubmed

Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid.

KCNK2 KCNK10

4.48e-06343225197053
Pubmed

Inhalational anesthetics activate two-pore-domain background K+ channels.

KCNK2 KCNK4

4.48e-06343210321245
Pubmed

Dysfunction of KCNK potassium channels impairs neuronal migration in the developing mouse cerebral cortex.

KCNK2 KCNK10

4.48e-06343223236211
Pubmed

The structure and functions of human lysophosphatidic acid acyltransferases.

AGPAT3 AGPAT4

8.94e-06443211487472
Pubmed

Regulation of FSHbeta and GnRH receptor gene expression in activin receptor II knockout male mice.

INHA GNRHR

8.94e-06443214654247
Pubmed

Sensory-Derived Glutamate Regulates Presynaptic Inhibitory Terminals in Mouse Spinal Cord.

SLC17A7 NTRK2

8.94e-06443227263971
Pubmed

Characterization of sensory neuronal subtypes innervating mouse tongue.

MRGPRD NTRK2

1.49e-05543230408082
Pubmed

Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARalpha in murine heart.

AGPAT3 AGPAT4

2.23e-05643215367102
Pubmed

Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein.

KCNK4 KCNK10

3.12e-05743218516069
Pubmed

A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K(+) Channels.

KCNK4 KCNK10

4.16e-05843226919430
Pubmed

Distinct Modes of Presynaptic Inhibition of Cutaneous Afferents and Their Functions in Behavior.

MRGPRD NTRK2

6.68e-051043230826183
Pubmed

Deep Sequencing of Somatosensory Neurons Reveals Molecular Determinants of Intrinsic Physiological Properties.

MRGPRD NTRK2

8.15e-051143231248728
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

MMS22L ATP11A GSTO2 YIPF1 PIGF DIPK1A ACBD5 AGPAT3

1.23e-04124243830973865
Pubmed

Parallel ascending spinal pathways for affective touch and pain.

MRGPRD NTRK2

1.35e-041443233116307
Pubmed

DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon.

MRGPRD NTRK2

1.55e-041543237541195
Pubmed

Dynamic regulation of the expression of neurotrophin receptors by Runx3.

SLC17A7 NTRK2

1.55e-041543218385258
Pubmed

Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling.

MRGPRD NTRK2

1.55e-041543220064391
Pubmed

p75 Is Required for the Establishment of Postnatal Sensory Neuron Diversity by Potentiating Ret Signaling.

MRGPRD NTRK2

2.26e-041843229045838
Pubmed

EphrinB3/EphA4-mediated guidance of ascending and descending spinal tracts.

SLC17A7 NTRK2

2.26e-041843224360544
Pubmed

A genome-wide association study of sleep habits and insomnia.

CACNA1C TMC5

2.26e-041843223728906
Pubmed

Neurog2 Deficiency Uncovers a Critical Period of Cell Fate Plasticity and Vulnerability among Neural-Crest-Derived Somatosensory Progenitors.

MRGPRD NTRK2

2.52e-041943231801063
Pubmed

C-LTMRs mediate wet dog shakes via the spinoparabrachial pathway.

MRGPRD NTRK2

2.52e-041943238915692
Pubmed

Tlx3 and Runx1 act in combination to coordinate the development of a cohort of nociceptors, thermoceptors, and pruriceptors.

SLC17A7 MRGPRD

2.52e-041943222787056
Pubmed

Skin-type-dependent development of murine mechanosensory neurons.

SLC17A7 NTRK2

2.52e-041943237607547
Pubmed

Ontogeny of excitatory spinal neurons processing distinct somatic sensory modalities.

SLC17A7 NTRK2

2.52e-041943224027274
Pubmed

Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation.

MRGPRD NTRK2

2.80e-042043233789102
Pubmed

Mechanoreceptor signal convergence and transformation in the dorsal horn flexibly shape a diversity of outputs to the brain.

MRGPRD NTRK2

2.80e-042043236334588
Pubmed

A developmental switch in the response of DRG neurons to ETS transcription factor signaling.

SLC17A7 NTRK2

3.09e-042143215836427
Pubmed

Hierarchical Specification of Pruriceptors by Runt-Domain Transcription Factor Runx1.

MRGPRD NTRK2

3.09e-042143228476948
Pubmed

Axonal projections of mechanoreceptive dorsal root ganglion neurons depend on Ret.

SLC17A7 NTRK2

3.72e-042343220534675
Pubmed

Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation.

MRGPRD NTRK2

3.72e-042343220096094
Pubmed

Sidekick 2 directs formation of a retinal circuit that detects differential motion.

SLC17A7 SDK2

3.72e-042343226287463
Pubmed

SSRI treatment modifies the effects of maternal inflammation on in utero physiology and offspring neurobiology.

IL17RA SLC22A3

4.40e-042543236343752
Pubmed

ISL1 is necessary for auditory neuron development and contributes toward tonotopic organization.

SLC17A7 NTRK2

5.53e-042843236074819
Pubmed

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

HELZ2 TMEM209 NAV2 RHBDF2 NTRK2

5.79e-0455243510737800
Pubmed

Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation.

SCD5 AGPAT3

6.35e-043043231693883
Pubmed

Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India.

KCNK2 NTRK2

6.35e-043043220083228
Pubmed

Proper formation of whisker barrelettes requires periphery-derived Smad4-dependent TGF-beta signaling.

SLC17A7 NTRK2

6.79e-043143221300867
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

KCNK2 CACNA1C KCNK4

6.86e-0413943316985003
Pubmed

Normal Molecular Specification and Neurodegenerative Disease-Like Death of Spinal Neurons Lacking the SNARE-Associated Synaptic Protein Munc18-1.

CACNA1C NTRK2

7.23e-043243226758845
Pubmed

c-Maf is required for the development of dorsal horn laminae III/IV neurons and mechanoreceptive DRG axon projections.

SLC17A7 NTRK2

7.23e-043243222514301
Pubmed

A high-resolution radiation hybrid map of the proximal portion of mouse chromosome 5.

GNRHR KCNK4

7.69e-043343210843805
Pubmed

Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA.

MRGPRD NTRK2

7.69e-043343230917309
Pubmed

Direction selectivity in the retina is established independent of visual experience and cholinergic retinal waves.

MRGPRD NTRK2

8.66e-043543218498732
Pubmed

Reduced lifespan of mice lacking catalase correlates with altered lipid metabolism without oxidative damage or premature aging.

KL SCD5

8.66e-043543230818059
Pubmed

Neurog1 and Neurog2 coordinately regulate development of the olfactory system.

SLC17A7 NTRK2

9.16e-043643222906231
Pubmed

Serum response factor mediates NGF-dependent target innervation by embryonic DRG sensory neurons.

MRGPRD NTRK2

9.67e-043743218498735
Pubmed

Heart neurons use clock genes to control myocyte proliferation.

CACNA1C NTRK2

9.67e-043743234851661
Pubmed

Diverse spinal commissural neuron populations revealed by fate mapping and molecular profiling using a novel Robo3Cre mouse.

SLC17A7 NTRK2

1.13e-034043231152445
Pubmed

The DNA sequence and analysis of human chromosome 13.

ZDHHC20 ATP11A KL

1.23e-0317043315057823
InteractionTSPAN8 interactions

SLC38A7 ZDHHC20 AGPAT3 AGPAT4

1.46e-0575404int:TSPAN8
InteractionNIPAL1 interactions

MAN1A2 GALNT16 AGPAT3 AGPAT4

7.58e-05114404int:NIPAL1
InteractionTMX2 interactions

IL17RA YIPF1 CNGA3 AGPAT3 AGPAT4

9.36e-05233405int:TMX2
InteractionCNGA3 interactions

SLC17A7 CNGA3 ACBD5

1.18e-0448403int:CNGA3
Cytoband20q13.33

HELZ2 SLC17A9

2.52e-037943220q13.33
Cytoband17q25.1

SDK2 RHBDF2

2.65e-038143217q25.1
GeneFamilyPotassium two pore domain channel subfamily K

KCNK2 KCNK4 KCNK10

2.72e-0615343277
GeneFamily1-acylglycerol-3-phosphate O-acyltransferases

AGPAT3 AGPAT4

1.87e-041134246
GeneFamilySolute carriers

SLC17A7 SLC38A7 SLC17A9 SLC22A3

6.20e-03395344752
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Nxph2_Wls|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

KCNK2 SLC17A7 KL IL17RA SDK2

1.64e-0713043505d5a73acf1d7f75a79876b1a06d27c74a89b8a4
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KCNK2 KL SDK2 ADTRP GALNT16

5.87e-071684357abaddbcc55e44653d54aa15464266aa6bd5c9d2
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_CPZ|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KCNK2 KL SDK2 TMC5 ADTRP

6.59e-071724351cfea985c5959b38beea351b892cd5e92e27f927
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KCNK2 SLC17A7 SDK2 ADTRP GALNT16

6.98e-07174435e4d65fe121a32ac4cdd6312e7b8f867f0852e991
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KCNK2 KL SDK2 ADTRP GALNT16

7.18e-0717543590e29945aa861082c94bb4f331161adc3a6ef899
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KCNK2 KL SDK2 ADTRP GALNT16

7.38e-07176435e4b21fd6a5e0c5950f27c3e1868318e48330ae5e
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC17A7 KL SDK2 ADTRP GALNT16

7.59e-071774354c069f0d044a96118090b85ca592a21d6b5d9399
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KL SDK2 ADTRP GALNT16 CNGA3

8.03e-071794357954c0026754ab869b88ab7feb13c2f27d6e272d
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_CPZ|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KCNK2 KL SDK2 TMC5 ADTRP

8.25e-07180435a499548391e6833b78f6e920f8e32a755814a9da
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC17A7 KL SDK2 ADTRP GALNT16

8.25e-07180435b514c55e52b46e8a1a2f09ed2c59a7683367a505
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_VISp_Col27a1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

KCNK2 SLC17A7 IL17RA KCNK4

1.47e-05154434d22902d2922784583f7016453768ed05b14b965e
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Pld5|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SLC17A7 IL17RA KCNK4 SLC22A3

1.66e-05159434a082e770fa757c4a1d3ed13d53f83297e36faf05
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

KCNK2 SLC17A7 IL17RA SDK2

1.79e-0516243458da6bc04cdac0002b0e6a751c96ff95e1a7f70f
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Ctxn3_Sla|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

KCNK2 SLC17A7 IL17RA SDK2

1.79e-051624344d13c271b4f63cf32980e5643b5d5951165fe8b5
ToppCellfacs-Large_Intestine-Proximal-18m-Epithelial-Enterocyte_(Proximal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP11A ADTRP REEP3 ABHD6

1.97e-0516643422b31acbbef1936ce19b393cf880c63ea2fa0f1b
ToppCellAdult-Mesenchymal-myofibroblast_cell|Adult / Lineage, Cell type, age group and donor

CACNA1C SDK2 INHA GALNT16

2.02e-05167434d584a8548a5317bd9686b3be8246ae6ed568796b
ToppCellfacs-Marrow-Granulocytes-24m-Hematologic-hematopoietic_stem_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NAV2 SDK2 INHA GBGT1

2.16e-051704348d3c51364a332020810836e2055c60893c10d7f3
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_CPZ|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KL SDK2 TMC5 ADTRP

2.16e-05170434021c3e45955d18e241f7d98acdf22076fee4fc43
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_CPZ|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KCNK2 KL SDK2 TMC5

2.37e-05174434ccc59416548ed3b783fd7a050ab32076c4296254
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_CPZ|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KL SDK2 TMC5 ADTRP

2.53e-051774340721199be6d29777dc0f47845aafd027fd376a32
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_CPZ|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KCNK2 KL SDK2 TMC5

2.53e-0517743457033ee0d49a4a50fc25328a4a44d4de2b35f505
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KL SDK2 ADTRP GALNT16

2.53e-05177434bde307e67ad8e48a5ff4c0827015f4688f6b3e46
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KL SDK2 ADTRP GALNT16

2.59e-05178434431e7557b8e8764e16e9e48368ce6bfa3c61561a
ToppCellCOVID-19-Epithelial_cells-AT1|COVID-19 / group, cell type (main and fine annotations)

NAV2 ATP11A TMC5 SCD5

2.65e-05179434a0b33bd69ffdfd5d38d80207fb40058a490aa19e
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|Children_(3_yrs) / Lineage, Cell type, age group and donor

NAV2 ATP11A TMC5 SLC22A3

2.65e-05179434cb38b54261a7af5ee3347e64c8aa880a77ed0763
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KL SDK2 ADTRP GALNT16

2.65e-05179434f65889bf1e41396979cce44a5e63f49dea2bbd9b
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KL SDK2 ADTRP GALNT16

2.77e-0518143408f44323bf71b6004a921bbc969c954c75feeb66
ToppCellCOVID-19-Epithelial_cells-ECM-high_epithelial|COVID-19 / group, cell type (main and fine annotations)

NAV2 CACNA1C TMC5 SLC22A3

2.89e-05183434dc1d380bf7564f290256cb7108063d1bd2da732b
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KL SDK2 ADTRP GALNT16

2.89e-0518343465f2a5895d166189a095cf7ea9dda171f0419b08
ToppCellControl-Epithelial-Club|World / Disease state, Lineage and Cell class

NAV2 TMC5 SCD5 SLC22A3

3.08e-051864349798428691408e17ff2af2fe2d1b345f074d67e4
ToppCellCOPD-Epithelial-Club|World / Disease state, Lineage and Cell class

NAV2 TMC5 SCD5 SLC22A3

3.08e-051864343006f4ab1eaf1eb34c10ca9f7c869603d2d25744
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NAV2 SCD5 NTRK2 AGPAT4

3.14e-051874347ea8731288e2a99f45e3958590ee1d76f49ae888
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NAV2 ATP11A TMC5 SCD5

3.21e-05188434eea652bab161f19148a883e7e3fe2523b36b3cea
ToppCellIPF-Epithelial-Club|IPF / Disease state, Lineage and Cell class

NAV2 TMC5 SCD5 SLC22A3

3.27e-05189434f3fcef008ef252b29ac6d567fef27f9acf9cd70f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NAV2 SCD5 NTRK2 AGPAT4

3.34e-051904343dcadabbefe0128a5f30ab51234f049ab4d870c6
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NAV2 ATP11A TMC5 SLC22A3

3.41e-05191434ca5669bd6f4a17471acae3eb229f845cc2e08efa
ToppCellEpithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|World / Lineage, Cell type, age group and donor

NAV2 ATP11A TMC5 SLC22A3

3.41e-05191434d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NAV2 SCD5 NTRK2 AGPAT4

3.41e-05191434963f4f2e852bbb4faf070aafb0d368297abacd3b
ToppCellAdult-Epithelial|Adult / Lineage, Cell type, age group and donor

NAV2 ATP11A TMC5 SLC22A3

3.48e-05192434efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCellEpithelial|World / Lineage, Cell type, age group and donor

NAV2 ATP11A TMC5 SLC22A3

3.48e-05192434499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCellControl-Epithelial-Club|Control / Disease state, Lineage and Cell class

NAV2 TMC5 SCD5 SLC22A3

3.48e-05192434d84ed1ea4a03edaa18c804f75afb03bd7b1f0e16
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NAV2 ATP11A TMC5 SLC22A3

3.48e-0519243429f49f00770c991b5f27e4cb701dd2d2d6cb7178
ToppCell(7)_Epithelial-C_(AT2)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

ATP11A GSTO2 TMC5 SLC22A3

3.55e-05193434a3ca6ab20c8de260e410ddc14d3d202f28b9d6c2
ToppCellEpithelial-club_cell|World / Lineage, Cell type, age group and donor

NAV2 TMC5 SCD5 SLC22A3

3.55e-051934342bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCellFetal_29-31_weeks-Epithelial|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NAV2 ATP11A TMC5 SLC22A3

3.55e-05193434a0ca3231992f14abcf1a6129573bace320e89d2a
ToppCellnucseq-Epithelial-Epithelial_Alveolar|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NAV2 ATP11A TMC5 SLC22A3

3.63e-0519443453f3e49e91b1096f3226010e2de767efb490dfe4
ToppCellnucseq-Epithelial|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NAV2 ATP11A TMC5 SLC22A3

3.70e-051954349406866f99555198a9be311fbd65751b70f35446
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland-Myoepithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NAV2 CACNA1C NTRK2 AGPAT4

3.85e-05197434f0475ad9c09c6da418dba17d3d3c1aaa2ef9ab4e
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

NAV2 TMEM229A NTRK2 SLC22A3

3.85e-05197434b9745e382baa2725dfcae060701fb53f6c8a31fa
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

NAV2 TMEM229A NTRK2 SLC22A3

3.85e-051974345afddde4e2b5cd55abe11e9b9efae02dbdc3da3a
ToppCell10x3'2.3-week_17-19-Mesenchymal_adipo-stroma-adipo-CAR|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

NAV2 TMEM229A NTRK2 SLC22A3

3.85e-051974341baffd087ca194a7355fefbb3bf67befb14fe2de
ToppCellNeuronal-Excitatory-eD(FEZF2)-ABO---L5-6|Neuronal / cells hierarchy compared to all cells using T-Statistic

KCNK2 KL SDK2 ADTRP

4.08e-052004347b845aabfbdfe893acc9334a5707833761bed60b
ToppCellNeuronal-Excitatory-eD(FEZF2)-ABO-|Neuronal / cells hierarchy compared to all cells using T-Statistic

KCNK2 KL SDK2 ADTRP

4.08e-05200434e3051dcf9b5c8e4dc71a8080b7a7aafea46f2b2b
ToppCellNeuronal-Excitatory-eD(FEZF2)-ABO|Neuronal / cells hierarchy compared to all cells using T-Statistic

KCNK2 KL SDK2 ADTRP

4.08e-052004340638273fc0910f47fe7a0b6d9a8639b0e9976d13
ToppCellNeuronal-Excitatory-eD(FEZF2)-ABO--|Neuronal / cells hierarchy compared to all cells using T-Statistic

KCNK2 KL SDK2 ADTRP

4.08e-052004341ce9599cc9d8158e8842ca56f35fa7809c234849
ToppCell368C-Epithelial_cells-Epithelial-B_(AT2)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SDK2 SLC17A9 ACBD5

1.51e-04107433410b37beffaf637a2a64c9d0ce7baf81f4bc667c
ToppCell368C-Epithelial_cells-Epithelial-B_(AT2)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

SDK2 SLC17A9 ACBD5

1.51e-041074335bae4b3aede9bcbf7e88414e3453973cc8b0c3e7
ToppCellSubstantia_nigra-Neuronal-Excitatory|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

SLC17A7 CNGA3 KCNK4

2.01e-041184339f1d744f46d79ff2ab7f168f54fdbd9f4640dddd
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_ALM_Hpgd|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SDK2 ADTRP SCD5

2.44e-041264339b04ca8a46cc30119baf6ef27711a0b2a6b4a0c9
ToppCellAT2_cells-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

CACNA1C SCD5 INHA

2.73e-04131433ff4e618bd944f852bbd34438f740187aca82460f
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-cortical_neurons_1|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

SLC17A7 INHA ABHD6

3.39e-0414143373b3e967357cba7585d97ec9e9d48d3e94ebe31e
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_4|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

NAV2 RNF175 ABHD6

3.46e-041424335ef69032ed7dc5f2244b84e8c6662290bf59a34b
ToppCelldroplet-Lung-nan-3m-Myeloid-intermediate_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL17RA ACER3 DIPK1A

3.53e-041434334d11d53330a9197275a8851e1bbf55a113715a09
ToppCelldroplet-Lung-nan-3m-Myeloid-Intermediate_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL17RA ACER3 DIPK1A

3.53e-041434338b9f4d87d5faac7752c83e1992491fc5550600f8
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2|Hippocampus / BrainAtlas - Mouse McCarroll V32

SLC17A7 GALNT16 KCNK4

3.83e-041474338f725ff8fb4ced5db2643e80669d3f7945b820ab
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NAV2 TMC5 SLC22A3

3.91e-041484339fe3c0a5904b8e9a0f28130f8d84d4f2a819b06c
ToppCellTCGA-Blood_and_Bone_Marrow-Primary_Blood_Derived_Cancer_-_Peripheral_Blood-Leukemia-Acute_Myeloid_Leukemia-8|TCGA-Blood_and_Bone_Marrow / Sample_Type by Project: Shred V9

IL17RA RNF175 ACER3

3.99e-041494330c18acfc5f0a9dd25ee5c38f97498b3278e65b42
ToppCellFrontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

SLC17A7 SDK2 KCNK4

4.06e-041504339d5bbdca19da60e1a2121ef64ec8e1375a5dbf6d
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Krt80_Sla|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SLC17A7 IL17RA SDK2

4.14e-04151433f50c5ae9dae507df750df25e151b58685fec70ce
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_ALM_Cpa6|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SLC17A7 IL17RA SDK2

4.39e-0415443312cbc38bc1f7231c67e1d2d5e86e95bc12e24682
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L6_CT|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SLC17A7 IL17RA SDK2

4.56e-04156433fe383ce3a0c37f7343d7026cb51260a04d4c2829
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Lypd1_Gpr88|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

KCNK2 SLC17A7 KCNK4

4.64e-041574335aee90ad7aaa65fdabc23597451da5e48db8f4e6
ToppCellfacs-Trachea-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l1|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SDK2 INHA GBGT1

4.64e-041574331f21d78a467fe22c5ab75d0917b840c1ac93f32c
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-Tregs|GI_small-bowel / Manually curated celltypes from each tissue

RNF175 ADTRP NTRK2

4.64e-04157433c44bd530e396b08f16f284e185dcb830843959ea
ToppCellChildren_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1C GALNT16 GNRHR

4.73e-0415843384c0a215dabf697ada036c2b9592d0c61b5077de
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_ALM_Cbln4_Fezf2|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SLC17A7 IL17RA KCNK4

4.91e-04160433d8241404d775f9a709abdf17988f36293fcf4c58
ToppCelldroplet-Limb_Muscle-nan-24m-Myeloid-chondrocyte-like|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCD5 INHA KCNK10

4.91e-04160433984990be02642a562f0c60ea99c01f005e7c02c2
ToppCelldroplet-Lung-nan-21m-Myeloid-intermediate_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC17A7 IL17RA ACER3

4.91e-041604334738d0c73d8c3508e5b5beb6c61e0ad551d9b949
ToppCelldroplet-Lung-nan-21m-Myeloid-Intermediate_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC17A7 IL17RA ACER3

4.91e-041604330b8151037b28f52a21918856a1e9336e8d5edb90
ToppCellRV-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

CACNA1C NTRK2 SLC22A3

4.91e-0416043329c9b4770d0e73d59cffc7937b179484c76b6dcc
ToppCellPND01-03-samps-Myeloid-Macrophage-CD163+_Macrophage|PND01-03-samps / Age Group, Lineage, Cell class and subclass

SLC38A7 GBGT1 KCNK10

4.91e-041604334480a7d6bd48d06b4e5196faac868f31ab7ed3ad
ToppCellE16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ATP11A SCD5 SLC17A9

5.09e-041624338e0f03fcc25b2ea777e8478fbf771699cf93719c
ToppCellPND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2-AT1/AT2_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NAV2 ATP11A SCD5

5.09e-04162433d0d9c18a73bc0bf4f38308ef2eee8ae20f6a7918
ToppCellPND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1/AT2|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NAV2 ATP11A SCD5

5.09e-0416243306f5d6c0bb26fe9d5180bc2ebf2c54bf52e715f3
ToppCellfacs-Marrow-Granulocytes-24m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SDK2 INHA GBGT1

5.09e-041624332787be283b7a705647058aeb9bc54006ce5ffe95
ToppCellFetal_29-31_weeks-Epithelial-club_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NAV2 TMC5 SLC22A3

5.09e-041624335c9bc3c3857a99d8a3caf359a7eb279ce9cc1c81
ToppCellE16.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ATP11A SCD5 SLC17A9

5.09e-04162433e0417f1242edf71934fe62bccc55c4678f7ff4ac
ToppCellBasal_cells-Donor_03|World / lung cells shred on cell class, cell subclass, sample id

KL RNF175 SCD5

5.27e-04164433b15a26130a1ea1b370b6e3be21f02a0d6aaf6b3c
ToppCelldroplet-Lung-21m-Hematologic-myeloid-intermediate_monocyte|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SLC17A7 IL17RA ACER3

5.27e-04164433cd0794f84dfd346807e2d803723718b7f22e9232
ToppCelldroplet-Lung-21m-Hematologic-myeloid-intermediate_monocyte-intermediate_monocyte_l4|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SLC17A7 IL17RA ACER3

5.27e-0416443312251a49fd4af32d4edb58046245548c260cf04b
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4-Teffector/EM_CD4|GI_small-bowel / Manually curated celltypes from each tissue

NAV2 ADTRP NTRK2

5.37e-04165433ecaeb90a6bc27524ef6f2eefa72aec7315dbde3b
ToppCellfacs-Large_Intestine-Proximal-24m-Epithelial-Enterocyte_(Proximal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP11A ADTRP ABHD6

5.37e-04165433ce79d217df88035457cd58f679e72dd98722ae22
ToppCelldroplet-Kidney-nan-18m-Epithelial-Epcam____proximal_tube_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ATP11A TMEM229A ADTRP

5.46e-041664338ab18c9d911eb3a9970bba7a769294b0927538f7
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_SLITRK6|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KCNK2 SDK2 ADTRP

5.46e-04166433a907d39ca5cf023de633fe5f2b28759b7af4eebc
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

RHBDF2 SLC17A9 DIPK1A

5.56e-041674330130743084dbcb20e10f96715d30961122150cbf
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B-Plasma_Cell-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

RHBDF2 SLC17A9 DIPK1A

5.56e-041674337bcae3797d3a0811e7f39885afdfd29ec517f11b
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B-Plasma_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

RHBDF2 SLC17A9 DIPK1A

5.56e-04167433c6f0209a1ad797631fdfa3efab6db6b1d3e8e315
ToppCell10x3'2.3-week_17-19-Hematopoietic-HSC/MPP_and_pro-myeloid_DC_progenitor|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

KL RNF175 KCNK10

5.66e-041684332c42588ca9775270591485f9bf805fe8ab9c0671
ToppCellTCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-8|TCGA-Thryoid / Sample_Type by Project: Shred V9

NAV2 KL ADTRP

5.66e-0416843300646601548b0fee42ae16bfa5e93603bc7c5129
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Col23a1_Adamts2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SLC17A7 SDK2 SLC22A3

5.66e-041684333fe432267656aff81b6d92c18d1b6fc0cde73d6a
Drugriluzole

KCNK2 SLC17A7 CACNA1C KCNK4 KCNK10

1.87e-05174435CID000005070
DrugBucladesine sodium salt [16980-89-5]; Down 200; 7.8uM; HL60; HT_HG-U133A

SLC38A7 ATP11A MAN1A2 RHBDF2 ABHD6

3.16e-051944352741_DN
DrugPentamidine isethionate [140-64-7]; Down 200; 6.8uM; HL60; HT_HG-U133A

ATP11A ADTRP SCD5 RHBDF2 AGPAT4

3.32e-051964352473_DN
Drug(cis-) Nanophine [5072-45-7]; Down 200; 26.8uM; MCF7; HT_HG-U133A

TMEM209 ATP11A ADTRP SCD5 AGPAT3

3.40e-051974353889_DN
DrugLovastatin [75330-75-5]; Down 200; 9.8uM; MCF7; HT_HG-U133A

TMEM209 ATP11A SCD5 RHBDF2 ABHD6

3.40e-051974352854_DN
Drugcispentacin

GNRHR ABHD6

3.47e-055432CID000073305
Druggadolinium

KCNK2 CACNA1C KCNK4 GBGT1 KCNK10

3.56e-05199435CID000023982
DrugDiltiazem

KCNK2 CACNA1C KCNK10

3.94e-0535433ctd:D004110
DrugAC1NPPZW

KCNK2 NAV2 CACNA1C KCNK4

4.26e-05103434CID005183170
Drugsipatrigine

KCNK2 SLC17A7 KCNK4

4.66e-0537433CID000060803
DrugMefenamic Acid

KCNK2 KCNK4 KCNK10

5.47e-0539433ctd:D008528
DrugNiflumic Acid

KCNK2 KCNK4 KCNK10

6.84e-0542433ctd:D009544
Drugtetraethylammonium

KCNK2 CACNA1C KCNK4 SLC22A3 KCNK10

8.01e-05236435CID000005413
DrugFlufenamic Acid

KCNK2 KCNK4 KCNK10

8.42e-0545433ctd:D005439
DiseaseAnhedonia

KCNK2 SLC17A7 CACNA1C

5.71e-0624433C0178417
Diseaseheart conduction disease (implicated_via_orthology)

KCNK2 KCNK4 KCNK10

1.39e-0532433DOID:10273 (implicated_via_orthology)
Diseaseangiostatin measurement

SLC22A3 AGPAT4

3.10e-056432EFO_0008024
Diseaselipoprotein A measurement, apolipoprotein A 1 measurement

SLC22A3 AGPAT4

4.34e-057432EFO_0004614, EFO_0006925
Diseaseproprotein convertase subtilisin/kexin type 9 measurement

REEP3 ABHD6

4.70e-0422432EFO_0009312
DiseaseDevelopmental Academic Disorder

SLC17A7 KL

8.21e-0429432C1330966
DiseaseLearning Disorders

SLC17A7 KL

8.21e-0429432C0023186
DiseaseLearning Disturbance

SLC17A7 KL

8.21e-0429432C0751263
DiseaseAdult Learning Disorders

SLC17A7 KL

8.21e-0429432C0751262
DiseaseLearning Disabilities

SLC17A7 KL

8.21e-0429432C0751265
Diseasetriacylglycerol 54:5 measurement

MMS22L AGPAT3

1.00e-0332432EFO_0010423
Diseasechylomicron measurement, triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement

SLC22A3 AGPAT4

1.13e-0334432EFO_0008317, EFO_0008596, EFO_0020947
Diseasetriacylglycerol 52:4 measurement

GALNT16 AGPAT3

1.27e-0336432EFO_0010416
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

SLC22A3 AGPAT4

1.72e-0342432EFO_0008317, EFO_0008596, EFO_0020945
DiseaseMemory Loss

SLC17A7 KL

1.80e-0343432C0751295
DiseaseAge-Related Memory Disorders

SLC17A7 KL

1.80e-0343432C0751292
DiseaseMemory Disorder, Spatial

SLC17A7 KL

1.80e-0343432C0751294
DiseaseMemory Disorder, Semantic

SLC17A7 KL

1.80e-0343432C0751293
DiseaseMemory Disorders

SLC17A7 KL

1.80e-0343432C0025261
DiseaseMemory impairment

SLC17A7 KL

1.89e-0344432C0233794
Diseaseoverall survival, pancreatic carcinoma

CACNA1C KCNK10

2.34e-0349432EFO_0000638, EFO_0002618
Diseaseasthma exacerbation measurement, response to corticosteroid

CACNA1C KL

2.53e-0351432EFO_0007614, GO_0031960

Protein segments in the cluster

PeptideGeneStartEntry
SFLLWPSALIRIYYW

ABHD6

26

Q9BV23
LVLRSIYIVTWVYPW

ACER3

156

Q9NUN7
IYIVTWVYPWLRGLG

ACER3

161

Q9NUN7
AIIWPFIAQWLVYLY

ACBD5

511

Q5T8D3
LWLYFETGTWVYPVF

ADTRP

171

Q96IZ2
ILTVAWILGTFYYLW

GALNT16

11

Q8N428
YMPLWVYWFITGISI

IL17RA

316

Q96F46
YQPLVWFWILLGLAY

KCNK4

231

Q9NYG8
WEPNIAIVTILWEYY

MMS22L

416

Q6ZRQ5
YLDFYKPVVWFWILV

KCNK2

281

O95069
KPVVWFWILVGLAYF

KCNK2

286

O95069
YLLWPWFERLDVYGI

GSTO2

176

Q9H4Y5
FLIAWIPYAVVSVWS

OPN5

261

Q6U736
PLSIYWFVLYWLSLP

MRGPRD

236

Q8TDS7
YKPLVWFWILVGLAY

KCNK10

296

P57789
SLWPFSVFYLVWLYV

MOGAT3

51

Q86VF5
SVFYLVWLYVDWDTP

MOGAT3

56

Q86VF5
VGRDWPWIYFVTLII

CACNA1C

376

Q13936
TPYYVLGIWYWFDPE

GNRHR

281

P30968
SVLWVYLENWLPVSY

GBGT1

21

Q8N5D6
RPEVIETYWYLWRFT

MAN1A2

531

O60476
WERWIVYPPSFIFHY

INHA

276

P05111
VKYWITIDNPYVVAW

KL

231

Q9UEF7
WVQIVLWRQGFYYPL

HELZ2

1266

Q9BYK8
FSWLVVFVGSWIIYV

DIPK1A

31

Q5T7M9
FYEEWWFLVVIALVG

SDK2

1926

Q58EX2
FLLYYWVVPESPRWL

SLC22A3

281

O75751
TWKRVPIYVIFIYVW

TMEM229A

306

B2RXF0
PIYVIFIYVWELSWG

TMEM229A

311

B2RXF0
YVAGLVISPLWIYWN

PIGF

196

Q07326
VWFTDLWNYSIIPYL

NAV2

2356

Q8IVL1
TWYVTAIVIIKYIWP

SLC38A7

211

Q9NVC3
GGLTLLWVWYVYRYL

SLC17A9

191

Q9BYT1
FVVPTLVPWYIWGES

SCD5

201

Q86SK9
IFWYLFWLLVSYESP

SLC17A7

246

Q9P2U7
WFPLYYELKIAFVIW

REEP3

61

Q6NUK4
WLTAIALPVFYNWYL

CNGA3

171

Q16281
FYVVFSLLWGGVIWP

ATP11A

1041

P98196
VVLWEIFTYGKQPWY

NTRK2

741

Q16620
WVPVLFITFVVVWSY

ZDHHC20

16

Q5W0Z9
TIIYAYAWLVPLALW

YIPF1

166

Q9Y548
LLYVPLIGWTWYFLE

AGPAT3

126

Q9NRZ7
VVPLYFTIKLYWWRF

RNF175

91

Q8N4F7
YNVTYWPLWYIELAL

TMEM209

56

Q96SK2
YLWVVWIYRNLIGSV

TMC5

891

Q6UXY8
LAYVPIIGWMWYFTE

AGPAT4

126

Q9NRZ5
FAALVLWLYIYPINW

RHBDF2

816

Q6PJF5