Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA photolyase activity	CRY2 CRY1	4.97e-06	2	45	2	GO:0003913
GeneOntologyMolecularFunction	DNA (6-4) photolyase activity	CRY2 CRY1	4.97e-06	2	45	2	GO:0003914
GeneOntologyMolecularFunction	deoxyribodipyrimidine photo-lyase activity	CRY2 CRY1	4.97e-06	2	45	2	GO:0003904
GeneOntologyMolecularFunction	blue light photoreceptor activity	CRY2 CRY1	4.97e-06	2	45	2	GO:0009882
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	CRY2 CHD8 CHD7 POLE RAD54L CRY1	2.56e-05	262	45	6	GO:0140097
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	CHD8 CHD7 RAD54L	7.88e-05	37	45	3	GO:0140658
GeneOntologyMolecularFunction	calmodulin binding	ASPM MYO1G MYO5A ADCY8 SCN5A	1.63e-04	230	45	5	GO:0005516
GeneOntologyMolecularFunction	ATP-dependent activity	MYO1G CHD8 CHD7 MYO5A SMC3 ATAD3A RAD54L	4.13e-04	614	45	7	GO:0140657
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	CRY2 CHD8 CHD7 POLE RAD54L POLR2F CRY1	5.54e-04	645	45	7	GO:0140640
GeneOntologyMolecularFunction	photoreceptor activity	CRY2 CRY1	6.61e-04	17	45	2	GO:0009881
GeneOntologyMolecularFunction	phosphatidylinositol kinase activity	PIK3C2A PI4KA	1.56e-03	26	45	2	GO:0052742
GeneOntologyMolecularFunction	cytoskeletal motor activity	MYO1G MYO5A SMC3	2.38e-03	118	45	3	GO:0003774
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	CHD8 CHD7 RAD54L	2.93e-03	127	45	3	GO:0008094
GeneOntologyMolecularFunction	ATP hydrolysis activity	CHD8 CHD7 SMC3 ATAD3A RAD54L	3.03e-03	441	45	5	GO:0016887
GeneOntologyMolecularFunction	microfilament motor activity	MYO1G MYO5A	3.32e-03	38	45	2	GO:0000146
GeneOntologyMolecularFunction	lipid kinase activity	PIK3C2A PI4KA	3.85e-03	41	45	2	GO:0001727
GeneOntologyMolecularFunction	FAD binding	CRY2 CRY1	4.42e-03	44	45	2	GO:0071949
GeneOntologyBiologicalProcess	blue light signaling pathway	CRY2 CRY1	4.87e-06	2	46	2	GO:0009785
GeneOntologyBiologicalProcess	cellular response to blue light	CRY2 CRY1	4.87e-06	2	46	2	GO:0071483
GeneOntologyBiologicalProcess	negative regulation of circadian rhythm	CRY2 DRD2 CRY1	5.70e-06	16	46	3	GO:0042754
GeneOntologyBiologicalProcess	maintenance of location	CRY2 ASPM CHD7 DRD2 ACACB MYO5A CRY1	2.56e-05	396	46	7	GO:0051235
GeneOntologyBiologicalProcess	negative regulation of corticosteroid hormone secretion	CRY2 CRY1	4.85e-05	5	46	2	GO:2000847
GeneOntologyBiologicalProcess	negative regulation of steroid hormone secretion	CRY2 CRY1	4.85e-05	5	46	2	GO:2000832
GeneOntologyBiologicalProcess	negative regulation of glucocorticoid secretion	CRY2 CRY1	4.85e-05	5	46	2	GO:2000850
GeneOntologyBiologicalProcess	secretion	CRY2 MYO1G CHD7 DRD2 WDR41 ACACB MYO5A PIK3C2A ADCY8 SEC24A CRY1	5.85e-05	1221	46	11	GO:0046903
GeneOntologyBiologicalProcess	response to blue light	CRY2 CRY1	7.26e-05	6	46	2	GO:0009637
GeneOntologyBiologicalProcess	negative regulation of glucocorticoid receptor signaling pathway	CRY2 CRY1	7.26e-05	6	46	2	GO:2000323
GeneOntologyBiologicalProcess	secretion by cell	CRY2 MYO1G CHD7 DRD2 WDR41 MYO5A PIK3C2A ADCY8 SEC24A CRY1	9.53e-05	1064	46	10	GO:0032940
GeneOntologyBiologicalProcess	negative regulation of dopamine secretion	DRD2 MYO5A	1.01e-04	7	46	2	GO:0033602
GeneOntologyBiologicalProcess	negative regulation of secretion by cell	CRY2 DRD2 WDR41 MYO5A CRY1	1.11e-04	214	46	5	GO:1903531
GeneOntologyBiologicalProcess	regulation of lipid localization	CRY2 IRAK1 ACACB SEC24A CRY1	1.14e-04	215	46	5	GO:1905952
GeneOntologyBiologicalProcess	export from cell	CRY2 MYO1G CHD7 DRD2 WDR41 MYO5A PIK3C2A ADCY8 SEC24A CRY1	1.85e-04	1153	46	10	GO:0140352
GeneOntologyBiologicalProcess	negative regulation of secretion	CRY2 DRD2 WDR41 MYO5A CRY1	1.86e-04	239	46	5	GO:0051048
GeneOntologyBiologicalProcess	regulation of secretion by cell	CRY2 CHD7 DRD2 WDR41 MYO5A ADCY8 SEC24A CRY1	2.06e-04	740	46	8	GO:1903530
GeneOntologyBiologicalProcess	lipid localization	CRY2 IRAK1 DRD2 XKR6 ACACB SEC24A CRY1	2.36e-04	565	46	7	GO:0010876
GeneOntologyBiologicalProcess	negative regulation of lipid transport	CRY2 IRAK1 CRY1	2.65e-04	56	46	3	GO:0032369
GeneOntologyBiologicalProcess	negative regulation of transport	CRY2 IRAK1 DRD2 WDR41 MYO5A PIK3C2A CRY1	2.98e-04	587	46	7	GO:0051051
GeneOntologyBiologicalProcess	regulation of glucocorticoid receptor signaling pathway	CRY2 CRY1	3.17e-04	12	46	2	GO:2000322
GeneOntologyBiologicalProcess	hormone secretion	CRY2 CHD7 DRD2 MYO5A ADCY8 CRY1	3.23e-04	420	46	6	GO:0046879
GeneOntologyBiologicalProcess	regulation of secretion	CRY2 CHD7 DRD2 WDR41 MYO5A ADCY8 SEC24A CRY1	3.52e-04	801	46	8	GO:0051046
GeneOntologyBiologicalProcess	response to inactivity	DRD2 SCN5A	3.74e-04	13	46	2	GO:0014854
GeneOntologyBiologicalProcess	negative regulation of synaptic transmission, glutamatergic	DRD2 MYO5A	3.74e-04	13	46	2	GO:0051967
GeneOntologyBiologicalProcess	hormone transport	CRY2 CHD7 DRD2 MYO5A ADCY8 CRY1	3.76e-04	432	46	6	GO:0009914
GeneOntologyBiologicalProcess	regulation of glucocorticoid secretion	CRY2 CRY1	4.35e-04	14	46	2	GO:2000849
GeneOntologyBiologicalProcess	response to morphine	DRD2 ADCY8	5.02e-04	15	46	2	GO:0043278
GeneOntologyBiologicalProcess	glucocorticoid secretion	CRY2 CRY1	5.72e-04	16	46	2	GO:0035933
GeneOntologyBiologicalProcess	response to isoquinoline alkaloid	DRD2 ADCY8	5.72e-04	16	46	2	GO:0014072
GeneOntologyBiologicalProcess	circadian regulation of gene expression	CRY2 DRD2 CRY1	6.26e-04	75	46	3	GO:0032922
GeneOntologyBiologicalProcess	nuclear receptor-mediated glucocorticoid signaling pathway	CRY2 CRY1	6.48e-04	17	46	2	GO:0042921
GeneOntologyBiologicalProcess	locomotion involved in locomotory behavior	DRD2 MYO5A	6.48e-04	17	46	2	GO:0031987
GeneOntologyBiologicalProcess	regulation of lipid transport	CRY2 IRAK1 SEC24A CRY1	6.73e-04	179	46	4	GO:0032368
GeneOntologyBiologicalProcess	negative regulation of lipid localization	CRY2 IRAK1 CRY1	7.02e-04	78	46	3	GO:1905953
GeneOntologyBiologicalProcess	nuclear receptor-mediated corticosteroid signaling pathway	CRY2 CRY1	7.28e-04	18	46	2	GO:0031958
GeneOntologyBiologicalProcess	negative regulation of synaptic transmission	DRD2 MYO5A ADCY8	7.56e-04	80	46	3	GO:0050805
GeneOntologyBiologicalProcess	regulation of growth hormone secretion	CHD7 DRD2	8.12e-04	19	46	2	GO:0060123
GeneOntologyBiologicalProcess	lipid transport	CRY2 IRAK1 DRD2 XKR6 SEC24A CRY1	8.62e-04	506	46	6	GO:0006869
GeneOntologyBiologicalProcess	prepulse inhibition	CHD8 DRD2	9.01e-04	20	46	2	GO:0060134
GeneOntologyBiologicalProcess	regulation of corticosteroid hormone secretion	CRY2 CRY1	9.95e-04	21	46	2	GO:2000846
GeneOntologyBiologicalProcess	growth hormone secretion	CHD7 DRD2	1.09e-03	22	46	2	GO:0030252
GeneOntologyBiologicalProcess	response to peptide hormone	CRY2 MYO5A PIK3C2A UMODL1 ADCY8 CRY1	1.10e-03	530	46	6	GO:0043434
GeneOntologyBiologicalProcess	regulation of hormone secretion	CRY2 CHD7 DRD2 ADCY8 CRY1	1.13e-03	355	46	5	GO:0046883
GeneOntologyBiologicalProcess	organic hydroxy compound transport	IRAK1 DRD2 ACACB MYO5A SEC24A	1.17e-03	358	46	5	GO:0015850
GeneOntologyBiologicalProcess	negative regulation of catecholamine secretion	DRD2 MYO5A	1.19e-03	23	46	2	GO:0033604
GeneOntologyBiologicalProcess	phosphatidylinositol-mediated signaling	PIK3C2A PI4KA	1.30e-03	24	46	2	GO:0048015
GeneOntologyBiologicalProcess	corticosteroid hormone secretion	CRY2 CRY1	1.30e-03	24	46	2	GO:0035930
GeneOntologyBiologicalProcess	response to glucagon	ADCY8 CRY1	1.41e-03	25	46	2	GO:0033762
GeneOntologyBiologicalProcess	entrainment of circadian clock by photoperiod	CRY2 CRY1	1.41e-03	25	46	2	GO:0043153
GeneOntologyBiologicalProcess	adenylate cyclase-activating adrenergic receptor signaling pathway	DRD2 GPR101	1.41e-03	25	46	2	GO:0071880
GeneOntologyBiologicalProcess	regulation of monoatomic cation transmembrane transport	CHD7 DRD2 MYO5A PIK3C2A SCN5A	1.52e-03	380	46	5	GO:1904062
GeneOntologyBiologicalProcess	chemical homeostasis	CRY2 CHD7 DRD2 ACACB MYO5A ADCY8 SEC24A CYB561D2 CRY1	1.53e-03	1249	46	9	GO:0048878
GeneOntologyBiologicalProcess	negative regulation of hormone secretion	CRY2 DRD2 CRY1	1.57e-03	103	46	3	GO:0046888
GeneOntologyBiologicalProcess	positive regulation of MAPK cascade	IRAK1 ZNF622 DRD2 GPR101 MAP3K3 IL26	1.60e-03	571	46	6	GO:0043410
GeneOntologyBiologicalProcess	lipid storage	CRY2 ACACB CRY1	1.66e-03	105	46	3	GO:0019915
GeneOntologyBiologicalProcess	response to nitrogen compound	CRY2 IRAK1 DRD2 EDEM1 MYO5A PIK3C2A UMODL1 ADCY8 CRY1	1.74e-03	1272	46	9	GO:1901698
MousePheno	abnormal periosteum morphology	XYLT1 CHD7	1.93e-05	3	36	2	MP:0010971
Domain	DNA_photolyase	CRY2 CRY1	5.68e-06	2	45	2	PF00875
Domain	DNA_photolyase_N	CRY2 CRY1	5.68e-06	2	45	2	IPR006050
Domain	FAD_binding_7	CRY2 CRY1	5.68e-06	2	45	2	PF03441
Domain	Cryptochr/Photolyase_FAD-bd	CRY2 CRY1	5.68e-06	2	45	2	IPR005101
Domain	PHR_CRY_ALPHA_BETA	CRY2 CRY1	5.68e-06	2	45	2	PS51645
Domain	SNF2_N	CHD8 CHD7 RAD54L	6.17e-05	32	45	3	IPR000330
Domain	SNF2_N	CHD8 CHD7 RAD54L	6.17e-05	32	45	3	PF00176
Domain	BRK	CHD8 CHD7	8.46e-05	6	45	2	SM00592
Domain	BRK_domain	CHD8 CHD7	8.46e-05	6	45	2	IPR006576
Domain	BRK	CHD8 CHD7	8.46e-05	6	45	2	PF07533
Domain	PI3Ka	PIK3C2A PI4KA	2.02e-04	9	45	2	PF00613
Domain	-	PIK3C2A PI4KA	2.02e-04	9	45	2	1.25.40.70
Domain	PI3Ka	PIK3C2A PI4KA	2.02e-04	9	45	2	SM00145
Domain	PIK_HELICAL	PIK3C2A PI4KA	2.52e-04	10	45	2	PS51545
Domain	PI_Kinase	PIK3C2A PI4KA	2.52e-04	10	45	2	IPR015433
Domain	PInositide-3_kin_accessory_dom	PIK3C2A PI4KA	2.52e-04	10	45	2	IPR001263
Domain	TIL	VWF ZAN	3.69e-04	12	45	2	PF01826
Domain	C8	VWF ZAN	3.69e-04	12	45	2	PF08742
Domain	Unchr_dom_Cys-rich	VWF ZAN	4.35e-04	13	45	2	IPR014853
Domain	C8	VWF ZAN	4.35e-04	13	45	2	SM00832
Domain	TIL_dom	VWF ZAN	5.07e-04	14	45	2	IPR002919
Domain	PI3/4_kinase_CS	PIK3C2A PI4KA	5.84e-04	15	45	2	IPR018936
Domain	VWD	VWF ZAN	6.67e-04	16	45	2	SM00216
Domain	VWF_type-D	VWF ZAN	6.67e-04	16	45	2	IPR001846
Domain	-	PIK3C2A PI4KA	6.67e-04	16	45	2	1.10.1070.11
Domain	VWFD	VWF ZAN	6.67e-04	16	45	2	PS51233
Domain	PI3Kc	PIK3C2A PI4KA	6.67e-04	16	45	2	SM00146
Domain	VWD	VWF ZAN	6.67e-04	16	45	2	PF00094
Domain	P-loop_NTPase	ASPM MYO1G CHD8 CHD7 MYO5A SMC3 ATAD3A RAD54L	8.45e-04	848	45	8	IPR027417
Domain	PI3/4_kinase_cat_dom	PIK3C2A PI4KA	8.47e-04	18	45	2	IPR000403
Domain	PI3_PI4_kinase	PIK3C2A PI4KA	8.47e-04	18	45	2	PF00454
Domain	PI3_4_KINASE_3	PIK3C2A PI4KA	8.47e-04	18	45	2	PS50290
Domain	PI3_4_KINASE_1	PIK3C2A PI4KA	8.47e-04	18	45	2	PS00915
Domain	PI3_4_KINASE_2	PIK3C2A PI4KA	8.47e-04	18	45	2	PS00916
Domain	VWC_out	VWF ZAN	9.46e-04	19	45	2	SM00215
Domain	IQ	ASPM MYO5A SCN5A	9.78e-04	81	45	3	SM00015
Domain	IQ_motif_EF-hand-BS	ASPM MYO5A SCN5A	1.33e-03	90	45	3	IPR000048
Domain	IQ	ASPM MYO5A SCN5A	1.46e-03	93	45	3	PS50096
Domain	Chromo_domain	CHD8 CHD7	1.51e-03	24	45	2	IPR023780
Domain	Chromo	CHD8 CHD7	1.78e-03	26	45	2	PF00385
Domain	CHROMO_1	CHD8 CHD7	2.06e-03	28	45	2	PS00598
Domain	CHROMO_2	CHD8 CHD7	2.06e-03	28	45	2	PS50013
Domain	Helicase_C	CHD8 CHD7 RAD54L	2.18e-03	107	45	3	PF00271
Domain	HELICc	CHD8 CHD7 RAD54L	2.18e-03	107	45	3	SM00490
Domain	Helicase_C	CHD8 CHD7 RAD54L	2.24e-03	108	45	3	IPR001650
Domain	HELICASE_CTER	CHD8 CHD7 RAD54L	2.30e-03	109	45	3	PS51194
Domain	HELICASE_ATP_BIND_1	CHD8 CHD7 RAD54L	2.30e-03	109	45	3	PS51192
Domain	DEXDc	CHD8 CHD7 RAD54L	2.30e-03	109	45	3	SM00487
Domain	Helicase_ATP-bd	CHD8 CHD7 RAD54L	2.36e-03	110	45	3	IPR014001
Domain	Chromodomain-like	CHD8 CHD7	2.69e-03	32	45	2	IPR016197
Domain	Chromo/shadow_dom	CHD8 CHD7	2.86e-03	33	45	2	IPR000953
Domain	CHROMO	CHD8 CHD7	2.86e-03	33	45	2	SM00298
Domain	DNA/RNA_helicase_DEAH_CS	CHD8 CHD7	3.21e-03	35	45	2	IPR002464
Domain	VWFC_1	VWF ZAN	3.39e-03	36	45	2	PS01208
Domain	VWC	VWF ZAN	3.78e-03	38	45	2	SM00214
Domain	DEAH_ATP_HELICASE	CHD8 CHD7	3.78e-03	38	45	2	PS00690
Domain	Myosin_head_motor_dom	MYO1G MYO5A	3.78e-03	38	45	2	IPR001609
Domain	VWFC_2	VWF ZAN	3.78e-03	38	45	2	PS50184
Domain	MYOSIN_MOTOR	MYO1G MYO5A	3.78e-03	38	45	2	PS51456
Domain	Myosin_head	MYO1G MYO5A	3.78e-03	38	45	2	PF00063
Domain	MYSc	MYO1G MYO5A	3.78e-03	38	45	2	SM00242
Domain	VWF_dom	VWF ZAN	4.60e-03	42	45	2	IPR001007
Pathway	BIOCARTA_CIRCADIAN_PATHWAY	CRY2 CRY1	9.99e-05	6	37	2	M22067
Pathway	WP_MELATONIN_METABOLISM_AND_EFFECTS	CRY2 IRAK1 CRY1	1.22e-04	37	37	3	M39418
Pathway	BIOCARTA_CIRCADIAN_PATHWAY	CRY2 CRY1	1.40e-04	7	37	2	MM1578
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	MRPL17 IRAK1 CHD8 CHD7 TTF1 ATAD3A PI4KA	1.26e-06	410	47	7	26949251
Pubmed	Delay in feedback repression by cryptochrome 1 is required for circadian clock function.	CRY2 CRY1	1.79e-06	2	47	2	21236481
Pubmed	CRY1, CRY2 and PRKCDBP genetic variants in metabolic syndrome.	CRY2 CRY1	1.79e-06	2	47	2	25391456
Pubmed	Loss of circadian rhythm and light-induced suppression of pineal melatonin levels in Cry1 and Cry2 double-deficient mice.	CRY2 CRY1	1.79e-06	2	47	2	20825493
Pubmed	The ratio of intracellular CRY proteins determines the clock period length.	CRY2 CRY1	1.79e-06	2	47	2	26966073
Pubmed	Cognitive dysfunction, elevated anxiety, and reduced cocaine response in circadian clock-deficient cryptochrome knockout mice.	CRY2 CRY1	1.79e-06	2	47	2	24187535
Pubmed	The circadian clock components CRY1 and CRY2 are necessary to sustain sex dimorphism in mouse liver metabolism.	CRY2 CRY1	1.79e-06	2	47	2	19211562
Pubmed	Clock Regulation of Metabolites Reveals Coupling between Transcription and Metabolism.	CRY2 CRY1	1.79e-06	2	47	2	28380384
Pubmed	The expression of clock genes cry1 and cry2 in human colorectal cancer and tumor adjacent tissues correlates differently dependent on tumor location.	CRY2 CRY1	1.79e-06	2	47	2	29940771
Pubmed	Mice deficient in cryptochrome 1 (cry1 (-/-)) exhibit resistance to obesity induced by a high-fat diet.	CRY2 CRY1	1.79e-06	2	47	2	24782829
Pubmed	Redox potential: differential roles in dCRY and mCRY1 functions.	CRY2 CRY1	1.79e-06	2	47	2	11818067
Pubmed	Circadian oscillation of nucleotide excision repair in mammalian brain.	CRY2 CRY1	1.79e-06	2	47	2	19164551
Pubmed	Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2.	CRY2 CRY1	1.79e-06	2	47	2	10518585
Pubmed	Circadian intraocular pressure rhythm is generated by clock genes.	CRY2 CRY1	1.79e-06	2	47	2	16936122
Pubmed	Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms.	CRY2 CRY1	1.79e-06	2	47	2	10217146
Pubmed	Pleiotropic effects of cryptochromes 1 and 2 on free-running and light-entrained murine circadian rhythms.	CRY2 CRY1	1.79e-06	2	47	2	12696673
Pubmed	Analysis of autophosphorylating kinase activities of Arabidopsis and human cryptochromes.	CRY2 CRY1	1.79e-06	2	47	2	17073458
Pubmed	Mammalian cryptochromes impinge on cell cycle progression in a circadian clock-independent manner.	CRY2 CRY1	1.79e-06	2	47	2	22033214
Pubmed	Sleep deprivation effects on circadian clock gene expression in the cerebral cortex parallel electroencephalographic differences among mouse strains.	CRY2 CRY1	1.79e-06	2	47	2	18614689
Pubmed	Characterization of photolyase/blue-light receptor homologs in mouse and human cells.	CRY2 CRY1	1.79e-06	2	47	2	9801304
Pubmed	Synchronization of cellular clocks in the suprachiasmatic nucleus.	CRY2 CRY1	1.79e-06	2	47	2	14631044
Pubmed	Autonomic and cardiovascular responses to scent stimulation are altered in cry KO mice.	CRY2 CRY1	1.79e-06	2	47	2	17175102
Pubmed	Measurement of internal body time by blood metabolomics.	CRY2 CRY1	1.79e-06	2	47	2	19487679
Pubmed	Further characterization of the phenotype of mCry1/mCry2-deficient mice.	CRY2 CRY1	1.79e-06	2	47	2	11587085
Pubmed	Cancer, hear my battle CRY.	CRY2 CRY1	1.79e-06	2	47	2	32291799
Pubmed	CHD8 interacts with CHD7, a protein which is mutated in CHARGE syndrome.	CHD8 CHD7	1.79e-06	2	47	2	20453063
Pubmed	Suppression of circadian clock protein cryptochrome 2 promotes osteoarthritis.	CRY2 CRY1	1.79e-06	2	47	2	32339698
Pubmed	Putative human blue-light photoreceptors hCRY1 and hCRY2 are flavoproteins.	CRY2 CRY1	1.79e-06	2	47	2	8909283
Pubmed	CRY1 and CRY2 genetic variants in seasonality: A longitudinal and cross-sectional study.	CRY2 CRY1	1.79e-06	2	47	2	27267441
Pubmed	Vagal regulation of respiratory clocks in mice.	CRY2 CRY1	1.79e-06	2	47	2	17442820
Pubmed	Circadian rhythm of RNA N6-methyladenosine and the role of cryptochrome.	CRY2 CRY1	1.79e-06	2	47	2	26239657
Pubmed	Altered food-anticipatory activity rhythm in Cryptochrome-deficient mice.	CRY2 CRY1	1.79e-06	2	47	2	15893577
Pubmed	Circadian behavioral rhythms in Cry1/Cry2 double-deficient mice induced by methamphetamine.	CRY2 CRY1	1.79e-06	2	47	2	18258761
Pubmed	Colorectal carcinomas with CpG island methylator phenotype 1 frequently contain mutations in chromatin regulators.	CHD8 CHD7	1.79e-06	2	47	2	24211491
Pubmed	Mammalian clock gene Cryptochrome regulates arthritis via proinflammatory cytokine TNF-alpha.	CRY2 CRY1	1.79e-06	2	47	2	20042581
Pubmed	Interval timing is intact in arrhythmic Cry1/Cry2-deficient mice.	CRY2 CRY1	1.79e-06	2	47	2	21775289
Pubmed	Control of skin cancer by the circadian rhythm.	CRY2 CRY1	1.79e-06	2	47	2	22025708
Pubmed	Circadian time-place learning in mice depends on Cry genes.	CRY2 CRY1	1.79e-06	2	47	2	18514517
Pubmed	Altered phase-relationship between peripheral oscillators and environmental time in Cry1 or Cry2 deficient mouse models for early and late chronotypes.	CRY2 CRY1	1.79e-06	2	47	2	24386234
Pubmed	Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses.	CRY2 CRY1	1.79e-06	2	47	2	9822380
Pubmed	The Potorous CPD photolyase rescues a cryptochrome-deficient mammalian circadian clock.	CRY2 CRY1	1.79e-06	2	47	2	21858120
Pubmed	Serine phosphorylation of mCRY1 and mCRY2 by mitogen-activated protein kinase.	CRY2 CRY1	1.79e-06	2	47	2	15298678
Pubmed	Structural differences in the FAD-binding pockets and lid loops of mammalian CRY1 and CRY2 for isoform-selective regulation.	CRY2 CRY1	1.79e-06	2	47	2	34172584
Pubmed	Cryptochrome-deficient mice lack circadian electrical activity in the suprachiasmatic nuclei.	CRY2 CRY1	1.79e-06	2	47	2	12121621
Pubmed	Expression of the blue-light receptor cryptochrome in the human retina.	CRY2 CRY1	1.79e-06	2	47	2	14507900
Pubmed	Light signalling in cryptochrome-deficient mice.	CRY2 CRY1	1.79e-06	2	47	2	14712914
Pubmed	Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver.	CRY2 CRY1	1.79e-06	2	47	2	24344304
Pubmed	Postnatal constant light compensates Cryptochrome1 and 2 double deficiency for disruption of circadian behavioral rhythms in mice under constant dark.	CRY2 CRY1	1.79e-06	2	47	2	24278295
Pubmed	High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry-deficient mice.	CRY2 CRY1	1.79e-06	2	47	2	23531614
Pubmed	Cryptochrome, circadian cycle, cell cycle checkpoints, and cancer.	CRY2 CRY1	1.79e-06	2	47	2	16061665
Pubmed	Daily variation in the electrophysiological activity of mouse medial habenula neurones.	CRY2 CRY1	1.79e-06	2	47	2	24247982
Pubmed	Deregulated expression of cryptochrome genes in human colorectal cancer.	CRY2 CRY1	1.79e-06	2	47	2	26768731
Pubmed	Network features of the mammalian circadian clock.	CRY2 CRY1	1.79e-06	2	47	2	19278294
Pubmed	Perspectives: neurobiology. The CRYs fo flies and mice.	CRY2 CRY1	1.79e-06	2	47	2	10636810
Pubmed	Photolyase/cryptochrome blue-light photoreceptors use photon energy to repair DNA and reset the circadian clock.	CRY2 CRY1	1.79e-06	2	47	2	12483519
Pubmed	Circadian clock cryptochrome proteins regulate autoimmunity.	CRY2 CRY1	1.79e-06	2	47	2	29109286
Pubmed	Reduced light response of neuronal firing activity in the suprachiasmatic nucleus and optic nerve of cryptochrome-deficient mice.	CRY2 CRY1	1.79e-06	2	47	2	22216107
Pubmed	Deregulated expression of cry1 and cry2 in human gliomas.	CRY2 CRY1	1.79e-06	2	47	2	23317246
Pubmed	Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines.	CRY2 CRY1	1.79e-06	2	47	2	22778400
Pubmed	Knockout-Rescue Embryonic Stem Cell-Derived Mouse Reveals Circadian-Period Control by Quality and Quantity of CRY1.	CRY2 CRY1	1.79e-06	2	47	2	28017587
Pubmed	A role for cryptochromes in sleep regulation.	CRY2 CRY1	1.79e-06	2	47	2	12495442
Pubmed	Restoring the Molecular Clockwork within the Suprachiasmatic Hypothalamus of an Otherwise Clockless Mouse Enables Circadian Phasing and Stabilization of Sleep-Wake Cycles and Reverses Memory Deficits.	CRY2 CRY1	1.79e-06	2	47	2	34446572
Pubmed	Clock gene defect disrupts light-dependency of autonomic nerve activity.	CRY2 CRY1	1.79e-06	2	47	2	17964540
Pubmed	Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression.	CRY2 CRY1	1.79e-06	2	47	2	19940241
Pubmed	Nuclear Proteomics Uncovers Diurnal Regulatory Landscapes in Mouse Liver.	CRY2 CRY1	1.79e-06	2	47	2	27818260
Pubmed	The involvement of Cry1 and Cry2 genes in the regulation of the circadian body temperature rhythm in mice.	CRY2 CRY1	1.79e-06	2	47	2	15331384
Pubmed	Cryptochromes are critical for the development of coherent circadian rhythms in the mouse suprachiasmatic nucleus.	CRY2 CRY1	1.79e-06	2	47	2	23575670
Pubmed	MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity.	IRAK1 WDR41 EDEM1 SMC3 POLE	1.85e-06	150	47	5	22678362
Pubmed	Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation.	FLNB SMC3 ATAD3A PI4KA	2.81e-06	72	47	4	36376293
Pubmed	Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis.	CRY2 CRY1	5.36e-06	3	47	2	21628572
Pubmed	Oligodendrocyte precursor survival and differentiation requires chromatin remodeling by Chd7 and Chd8.	CHD8 CHD7	5.36e-06	3	47	2	30108144
Pubmed	Regulation of apoptosis by the circadian clock through NF-kappaB signaling.	CRY2 CRY1	5.36e-06	3	47	2	21690409
Pubmed	Reduced alpha-adrenoceptor responsiveness and enhanced baroreflex sensitivity in Cry-deficient mice lacking a biological clock.	CRY2 CRY1	5.36e-06	3	47	2	15860530
Pubmed	Molecular clocks in mouse skin.	CRY2 CRY1	5.36e-06	3	47	2	19037239
Pubmed	Further evidence for the role of cryptochromes in retinohypothalamic photoreception/phototransduction.	CRY2 CRY1	5.36e-06	3	47	2	15010208
Pubmed	Circadian clock molecules CLOCK and CRYs modulate fibrinolytic activity by regulating the PAI-1 gene expression.	CRY2 CRY1	5.36e-06	3	47	2	16970803
Pubmed	Cell-autonomous clock of astrocytes drives circadian behavior in mammals.	CRY2 CRY1	5.36e-06	3	47	2	30630934
Pubmed	Quantitative analyses of cryptochrome-mBMAL1 interactions: mechanistic insights into the transcriptional regulation of the mammalian circadian clock.	CRY2 CRY1	5.36e-06	3	47	2	21521686
Pubmed	Loss of cryptochrome reduces cancer risk in p53 mutant mice.	CRY2 CRY1	5.36e-06	3	47	2	19188586
Pubmed	CRY1-CBS binding regulates circadian clock function and metabolism.	CRY2 CRY1	5.36e-06	3	47	2	32383312
Pubmed	Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome.	CRY2 CRY1	5.36e-06	3	47	2	28813682
Pubmed	A circadian clock regulates efflux by the blood-brain barrier in mice and human cells.	CRY2 CRY1	5.36e-06	3	47	2	33504784
Pubmed	Circadian clock genes directly regulate expression of the Na(+)/H(+) exchanger NHE3 in the kidney.	CRY2 CRY1	5.36e-06	3	47	2	15780093
Pubmed	Cryptochrome-dependent circadian periods in the arcuate nucleus.	CRY2 CRY1	5.36e-06	3	47	2	26542738
Pubmed	Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein.	CRY2 CRY1	5.36e-06	3	47	2	11889036
Pubmed	Loss of circadian rhythmicity in aging mPer1-/-mCry2-/- mutant mice.	CRY2 CRY1	5.36e-06	3	47	2	12782655
Pubmed	Genome-wide expression analysis of mouse liver reveals CLOCK-regulated circadian output genes.	CRY2 CRY1	5.36e-06	3	47	2	12865428
Pubmed	DNA damage-specific control of cell death by cryptochrome in p53-mutant ras-transformed cells.	CRY2 CRY1	5.36e-06	3	47	2	23149912
Pubmed	Differential roles for cryptochromes in the mammalian retinal clock.	CRY2 CRY1	5.36e-06	3	47	2	29561690
Pubmed	Timed exercise stabilizes behavioral rhythms but not molecular programs in the brain's suprachiasmatic clock.	CRY2 CRY1	5.36e-06	3	47	2	36866044
Pubmed	Intrinsic and extrinsic cues regulate the daily profile of mouse lateral habenula neuronal activity.	CRY2 CRY1	5.36e-06	3	47	2	25194046
Pubmed	Circadian regulation of food-anticipatory activity in molecular clock-deficient mice.	CRY2 CRY1	5.36e-06	3	47	2	23145013
Pubmed	Translational switching of Cry1 protein expression confers reversible control of circadian behavior in arrhythmic Cry-deficient mice.	CRY2 CRY1	5.36e-06	3	47	2	30487216
Pubmed	Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm.	CRY2 CRY1	5.36e-06	3	47	2	22549838
Pubmed	Effect of vitamin A depletion on nonvisual phototransduction pathways in cryptochromeless mice.	CRY2 CRY1	5.36e-06	3	47	2	15523112
Pubmed	Season-dependent associations of circadian rhythm-regulating loci (CRY1, CRY2 and MTNR1B) and glucose homeostasis: the GLACIER Study.	CRY2 CRY1	5.36e-06	3	47	2	25707907
Pubmed	Regulation of nucleotide excision repair activity by transcriptional and post-transcriptional control of the XPA protein.	CRY2 CRY1	5.36e-06	3	47	2	21193487
Pubmed	Suprachiasmatic nucleus grafts restore circadian behavioral rhythms of genetically arrhythmic mice.	CRY2 CRY1	5.36e-06	3	47	2	12699623
Pubmed	Lithium effects on circadian rhythms in fibroblasts and suprachiasmatic nucleus slices from Cry knockout mice.	CRY2 CRY1	5.36e-06	3	47	2	26930624
Pubmed	Association between AVPR1A, DRD2, and ASPM and endophenotypes of communication disorders.	ASPM DRD2	5.36e-06	3	47	2	24849541
Interaction	MKI67 interactions	ASPM MRPL17 IRAK1 CHD8 CHD7 SMC3 TTF1 ATAD3A PI4KA	1.09e-05	648	45	9	int:MKI67
Interaction	DNAJC7 interactions	CRY2 IRAK1 GREB1 WDR41 PIK3C2A PI4KA POLE	4.01e-05	425	45	7	int:DNAJC7
Interaction	PTGES3 interactions	IRAK1 CHD7 GREB1 PIK3C2A PI4KA POLE RAD54L	4.78e-05	437	45	7	int:PTGES3
GeneFamily	GATA zinc finger domain containing\|Myb/SANT domain containing	CHD7 TTF1	3.71e-03	53	31	2	532
Coexpression	GSE17721_CTRL_VS_POLYIC_24H_BMDC_UP	MYO5A CTSA PIK3C2A SMC3 ADCY8	2.55e-05	199	46	5	M3723
Coexpression	GSE40666_STAT1_KO_VS_STAT4_KO_CD8_TCELL_UP	TIGD2 PI4KA MAP3K3 POLR2F CYB561D2	2.55e-05	199	46	5	M9220
ToppCell	COVID-19-B_cells-Plasma_cells\|COVID-19 / group, cell type (main and fine annotations)	ASPM XKR6 EDEM1 SEC24A IL26	1.41e-06	183	47	5	130c109f63a5e3c8f83cb96e32f4addf513b6415
ToppCell	COVID-19-B_cells\|COVID-19 / group, cell type (main and fine annotations)	ASPM XKR6 EDEM1 SEC24A IL26	1.41e-06	183	47	5	2c016bb59f131a0e821853b085289a3583f0a729
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASPM VWF ACACB TTF1	7.60e-06	119	47	4	c3f1223356e7f245a460ea5568a223e34e458dc1
ToppCell	Globus_pallidus\|World / BrainAtlas - Mouse McCarroll V32	IRAK1 GPR101 ZAN SCN5A	9.53e-06	126	47	4	44b63f945d5bedf1a2ca1810e7e100276ea9dd89
ToppCell	Tracheal-10x5prime-Immune_Myeloid-Dendritic_cell-DC_plasmacytoid\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	XYLT1 SLC5A10 SPIB ZNF331	2.95e-05	168	47	4	c34dd4a9c54d8e9c8f118e6a3816548890cb0746
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Undifferentiated_Pleomorphic_Sarcoma-6\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	TRGV4 MYO1G IRAK1 CYB561D2	3.31e-05	173	47	4	7714d27e53b02af4e071154cf2ea001fab347235
ToppCell	PND10-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_G2M\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ASPM CCR3 POLE BICC1	3.62e-05	177	47	4	3e149bff1f1b393a7abe98984e37981c8296f95d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GREB1 SLC5A10 ADCY8 BICC1	3.78e-05	179	47	4	58ae5a97fe2a14e1c6fdeb886397eb06fdaf0428
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Nr2f2_(MGE-derived_cortical_interneurons--Martinotti_cells)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SLC5A10 GPR101 FAM187A	3.87e-05	62	47	3	a20620a8869721ea62984c2022ee1b484b455824
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Nr2f2_(MGE-derived_cortical_interneurons--Martinotti_cells)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	SLC5A10 GPR101 FAM187A	3.87e-05	62	47	3	ee694c06bcd924b4ddf744178ba3a99e04eed51b
ToppCell	wk_08-11-Hematologic-Myeloid-pre-pDC/DC5\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	TRGV4 ZAN SPIB UMODL1	4.03e-05	182	47	4	fec8a2d6d4099722b8e1bb41222108ed74268fcf
ToppCell	URO-Lymphocyte-T_NK-T_NK_proliferative\|URO / Disease, Lineage and Cell Type	ASPM RAD54L IL26 SCN5A	4.30e-05	185	47	4	0ae9c646679c69a553eda670aef0e0495feb0286
ToppCell	3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-T_cell-T_cells_proliferating-T_cells_proliferating_L.1.1.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ASPM MYO1G CCR3 RAD54L	4.77e-05	190	47	4	b69940d16685249167d4c2cf6ad8237ccf6f7590
ToppCell	pdx-Tumor_cells-T1\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ASPM POLE RAD54L ZNF331	4.77e-05	190	47	4	d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCell	Control-Lymphoid-CD4_T_cells\|Lymphoid / Condition, Lineage and Cell class	CHD7 PIK3C2A CYB561D2 CRY1	5.27e-05	195	47	4	8679a122fe796b1eddef82460e985b3fd3b3a2a5
ToppCell	3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ASPM VWF ZAN RAD54L	5.49e-05	197	47	4	76b61e60a757e58b465569538e632d6d9953e89a
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	FLNB CHD7 VWF PIK3C2A	5.82e-05	200	47	4	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	COVID_non-vent-Lymphocytic-Proliferative_Lymphocyte-\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	ASPM SMC3 POLE RAD54L	5.82e-05	200	47	4	04bf9e6a0fbd792b49eed63dabba5d6fafed8c07
ToppCell	COVID_non-vent-Lymphocytic-Proliferative_Lymphocyte\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	ASPM SMC3 POLE RAD54L	5.82e-05	200	47	4	f6b5320cdfe640a71e6e2df26f30d42e64b1c921
Disease	Mental Depression	CRY2 DRD2 ADCY8 BICC1 CRY1	4.19e-05	254	45	5	C0011570
Disease	COVID-19, obesity	CCR3 ADCY8	4.75e-05	7	45	2	EFO_0001073, MONDO_0100096
Disease	CHARGE syndrome (implicated_via_orthology)	CHD8 CHD7	4.75e-05	7	45	2	DOID:0050834 (implicated_via_orthology)
Disease	Depressive disorder	CRY2 DRD2 ADCY8 BICC1 CRY1	7.72e-05	289	45	5	C0011581
Disease	aggressive behaviour measurement, ADHD symptom measurement	XYLT1 DRD2 XKR6	1.55e-04	68	45	3	EFO_0007826, EFO_0007860
Disease	Seasonal Affective Disorder	CRY2 CRY1	2.69e-04	16	45	2	C0085159
Disease	coagulation factor measurement	ASPM VWF	4.25e-04	20	45	2	EFO_0004634
Disease	brain ischemia (biomarker_via_orthology)	IRAK1 DRD2 SCN5A	5.12e-04	102	45	3	DOID:2316 (biomarker_via_orthology)
Disease	Myeloid Leukemia, Chronic	CRY2 CRY1	8.99e-04	29	45	2	C0023473
Disease	Astigmatism	XYLT1 MYO1G BICC1	1.01e-03	129	45	3	HP_0000483
Disease	Hyperkinesia, Generalized	DRD2 ADCY8	1.10e-03	32	45	2	C0751217
Disease	Hyperkinesia	DRD2 ADCY8	1.10e-03	32	45	2	C3887506
Disease	internet addiction disorder	IRAK1 FLNB	1.17e-03	33	45	2	EFO_0803368

Protein segments in the cluster

Peptide	Gene	Start	Entry
LIVRYQRMNGRYNFK	UMODL1	1291	Q5DID0
NGRRIYYGMNALRAK	TTF1	751	Q15361
QRYFLGQRRKSEVVM	ADCY8	171	P40145
RLVTAYQRSYKREQM	CHD8	1751	Q9HCK8
RYRTMGNVARRKYAA	ARSI	251	Q5FYB1
TKKNRSLYRNILMYG	ATAD3A	386	Q9NVI7
HLYRTQYLKGVNRSM	FAM187A	306	A6NFU0
FKQRSRMYGATVIVR	BICC1	241	Q9H694
LITAYQRSYKRQQMR	CHD7	1916	Q9P2D1
QAFVRGYLVRKQMRL	ASPM	1736	Q8IZT6
IQVRCRAYYQGKMQR	ASPM	2146	Q8IZT6
RRYLYVRLDGTMSIK	RAD54L	536	Q92698
QRYRSGIRGYMKTVV	ACACB	1116	O00763
YIQRSRRLYGNTPMR	KIAA0100	946	Q14667
LYVRRQTARMRLSKY	GREB1	1446	Q4ZG55
VLSQKRMYRKYHQRP	FLNB	56	O75369
MLVYSGYSKETLRQR	PIK3C2A	1626	O00443
QIVQALRYDKMGYVR	PI4KA	1656	P42356
YRKVNRVLPRSNMVY	POLE	1381	Q07864
SKMTQRRGYLLLYGT	GPR101	141	Q96P66
VYRAVMRNTVYAVKR	IRAK1	226	P51617
RRLYRSMNSQYLKLL	CTSA	371	P10619
KYRRLRIMTNIYLLN	CCR3	61	P51677
ERMKQIYQQLSRYRG	CRY2	501	Q49AN0
IERMKQIYQQLSRYR	CRY1	481	Q16526
RMKRIFYRIGNKGIY	IL26	136	Q9NPH9
RRYSLPLKSIYMRQI	EDEM1	636	Q92611
LYNTRYSSKRRVTVM	DRD2	141	P14416
IMNQVSNAYLYRKRI	CYB561D2	206	O14569
TRKYTRQILEGMSYL	MAP3K3	466	Q99759
MYIKQVIIQGFRSYR	SMC3	1	Q9UQE7
QRYLTRKIGFEAVMR	SEC24A	736	O95486
RLYQQTLRSAGKIYM	SCN5A	376	Q14524
YMTKYERARVLGTRA	POLR2F	56	P61218
RMTYQKLARALRNYA	SPIB	221	Q01892
MSQGVLATVKRYYRA	TIGD2	326	Q4W5G0
YIRTMYLGIQSQRRK	XKR6	256	Q5GH73
GRASRQLQRMFKAIY	XYLT1	336	Q86Y38
QRMSRNFVRYVQGLK	VWF	1391	P04275
KRYGGQRIRMYLSVL	SLC5A10	126	A0PJK1
RLRQQLEMYSISRKY	SMIM19	76	Q96E16
RGRYVNQMIINYVKR	ZNF331	96	Q9NQX6
YDTYGSTRKNLRMIL	TRGV4	86	A0A0C4DH28
LMRYYKQRFGLSRAV	ZNF622	396	Q969S3
GRGLYVYSLQMKRVI	WDR41	301	Q9HAD4
RYKDQTGGYTRMLQI	MRPL17	96	Q9NRX2
SYRLQGRMTYVLIKT	ZAN	2346	Q9Y493
MRNLQLRFEKGRIYT	MYO1G	26	B0I1T2
KAAITMQRYVRGYQA	MYO5A	791	Q9Y4I1