Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	pantothenate kinase activity	PANK2 PANK3	1.68e-05	4	34	2	GO:0004594
Domain	Fibrinogen_C	ANGPTL6 ANGPTL5 CNTNAP1	1.71e-05	27	35	3	PF00147
Domain	Type_II_PanK	PANK2 PANK3	2.04e-05	4	35	2	IPR004567
Domain	Fumble	PANK2 PANK3	2.04e-05	4	35	2	PF03630
Domain	FBG	ANGPTL6 ANGPTL5 CNTNAP1	2.13e-05	29	35	3	SM00186
Domain	-	ANGPTL6 ANGPTL5 CNTNAP1	2.36e-05	30	35	3	3.90.215.10
Domain	Fibrinogen_a/b/g_C_1	ANGPTL6 ANGPTL5 CNTNAP1	2.36e-05	30	35	3	IPR014716
Domain	Fibrinogen_a/b/g_C_dom	ANGPTL6 ANGPTL5 CNTNAP1	2.88e-05	32	35	3	IPR002181
Domain	FIBRINOGEN_C_2	ANGPTL6 ANGPTL5 CNTNAP1	2.88e-05	32	35	3	PS51406
Domain	FIBRINOGEN_C_1	ANGPTL6 ANGPTL5 CNTNAP1	2.88e-05	32	35	3	PS00514
Domain	Propept_inh	CPB2 TPP1	4.56e-04	17	35	2	IPR009020
Domain	Fibrinogen_CS	ANGPTL6 ANGPTL5	5.72e-04	19	35	2	IPR020837
Domain	-	ANGPTL6 ANGPTL5	9.18e-04	24	35	2	4.10.530.10
Domain	Fibrinogen_a/b/g_C_2	ANGPTL6 ANGPTL5	9.18e-04	24	35	2	IPR014715
Domain	WW	STXBP4 WWC1	3.50e-03	47	35	2	PF00397
Domain	WW	STXBP4 WWC1	3.65e-03	48	35	2	SM00456
Domain	WW_DOMAIN_2	STXBP4 WWC1	4.11e-03	51	35	2	PS50020
Domain	WW_DOMAIN_1	STXBP4 WWC1	4.11e-03	51	35	2	PS01159
Domain	WW_dom	STXBP4 WWC1	4.27e-03	52	35	2	IPR001202
Pathway	REACTOME_COENZYME_A_BIOSYNTHESIS	PANK2 PANK3	8.53e-05	7	29	2	M27087
Pathway	REACTOME_COENZYME_A_BIOSYNTHESIS	PANK2 PANK3	8.53e-05	7	29	2	MM14765
Pubmed	Crystal structures of human pantothenate kinases. Insights into allosteric regulation and mutations linked to a neurodegeneration disorder.	PANK2 PANK3	2.95e-06	3	35	2	17631502
Pubmed	Compartmentalization of mammalian pantothenate kinases.	PANK2 PANK3	2.95e-06	3	35	2	23152917
Pubmed	SALM4 negatively regulates NMDA receptor function and fear memory consolidation.	GRIN2B LRFN3	2.95e-06	3	35	2	34588597
Pubmed	Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis.	PANK2 PANK3	2.95e-06	3	35	2	17379144
Pubmed	A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome.	PANK2 PANK3	5.90e-06	4	35	2	11479594
Pubmed	Germline deletion of pantothenate kinases 1 and 2 reveals the key roles for CoA in postnatal metabolism.	PANK2 PANK3	5.90e-06	4	35	2	22815849
Pubmed	Coenzyme A metabolism.	PANK2 PANK3	5.90e-06	4	35	2	2981478
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	KDM3B CEP192 PANK2 PANK3 NEK9 STXBP4 MPRIP	2.04e-05	861	35	7	36931259
Pubmed	Polymorphisms in C2, CFB and C3 are associated with progression to advanced age related macular degeneration associated with visual loss.	LRP6 ABCA4	8.89e-05	14	35	2	19015224
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	GRIN2B WRAP53 BACE2 JADE2 TPP1 CNTNAP1 MPRIP	2.51e-04	1285	35	7	35914814
Pubmed	SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion.	GRIN2B LRFN3	2.91e-04	25	35	2	27480238
Pubmed	Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice.	XYLT1 KL	3.15e-04	26	35	2	33905568
Pubmed	Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.	KDM3B JADE2 STXBP4	4.56e-04	149	35	3	25231870
Pubmed	Genome-scale RNAi screen for host factors required for HIV replication.	GRIN2B PANK3 BACE2 NEK9	4.64e-04	361	35	4	18976975
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	LTA4H KL JADE2 TPP1 STXBP4 PSMB5	4.81e-04	1016	35	6	19056867
Pubmed	Endogenous human MDM2-C is highly expressed in human cancers and functions as a p53-independent growth activator.	NEK9 ALDH16A1	6.07e-04	36	35	2	24147044
Pubmed	In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.	ANGPTL6 LTA4H CPB2 KL KRT28 TPP1	6.32e-04	1070	35	6	23533145
Pubmed	Gender differences in genetic risk profiles for cardiovascular disease.	CPB2 KL	9.90e-04	46	35	2	18974842
Pubmed	Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.	KDM3B JADE2	9.90e-04	46	35	2	21102462
Cytoband	5q34	PANK3 WWC1	2.76e-04	32	35	2	5q34
Cytoband	Ensembl 112 genes in cytogenetic band chr5q34	PANK3 WWC1	4.54e-04	41	35	2	chr5q34
Cytoband	19q13.12	CLIP3 LRFN3	1.40e-03	72	35	2	19q13.12
GeneFamily	Fibrinogen C domain containing\|Angiopoietin like	ANGPTL6 ANGPTL5	4.31e-05	8	23	2	905
GeneFamily	Fibrinogen C domain containing	ANGPTL6 ANGPTL5	4.56e-04	25	23	2	554
Drug	dipalmitoylphosphatidylethanolamine	ANGPTL6 LTA4H CPB2 BACE2	1.11e-06	51	35	4	CID000065109
Drug	D-pantothenoyl-L-cysteine	PANK2 PANK3	1.37e-05	4	35	2	CID000440217
Disease	pantothenate kinase-associated neurodegeneration (implicated_via_orthology)	PANK2 PANK3	7.27e-06	4	33	2	DOID:3981 (implicated_via_orthology)
Disease	lethal congenital contracture syndrome (is_implicated_in)	NEK9 CNTNAP1	2.54e-05	7	33	2	DOID:0060558 (is_implicated_in)
Disease	retinitis pigmentosa (biomarker_via_orthology)	KL GRIN2B	9.39e-05	13	33	2	DOID:10584 (biomarker_via_orthology)
Disease	visual epilepsy (implicated_via_orthology)	KDM3B HRH3	6.65e-04	34	33	2	DOID:11832 (implicated_via_orthology)
Disease	Memory Disorders	KL HRH3	1.06e-03	43	33	2	C0025261
Disease	Memory Loss	KL HRH3	1.06e-03	43	33	2	C0751295
Disease	Age-Related Memory Disorders	KL HRH3	1.06e-03	43	33	2	C0751292
Disease	Memory Disorder, Spatial	KL HRH3	1.06e-03	43	33	2	C0751294
Disease	Memory Disorder, Semantic	KL HRH3	1.06e-03	43	33	2	C0751293
Disease	Memory impairment	KL HRH3	1.11e-03	44	33	2	C0233794

Protein segments in the cluster

Peptide	Gene	Start	Entry
AGYADSGLDYLLWPQ	FAM222A	276	Q5U5X8
LGGIEPSLYKGDIWY	BACE2	251	Q9Y5Z0
GAEGWGYYGCDEELV	CNTNAP1	16	P78357
GCSWHGGPDGLYEYL	ALDH16A1	471	Q8IZ83
GLLAWYLDQVFPGDY	ABCA4	851	P78363
DYLDGFGDLLGEFWL	ANGPTL5	211	Q86XS5
EDLGGPYVWGQYDLL	LTA4H	246	P09960
IYLNGGRPEDGTYAW	DCDC1	1671	M0R2J8
WYEKYGPGSCRGLDH	KRT28	121	Q7Z3Y7
YGGWLLLAPDGTDFD	MPRIP	46	Q6WCQ1
VYSWGCGEYGRLGLD	NEK9	501	Q8TD19
PLANERAYWTGYGEG	NRAP	116	Q86VF7
PLGWEEAYDPQVGDY	WWC1	56	Q8IX03
LLTSWGDPYYIGLTG	KATNIP	1406	O60303
WPGGSRYDLDEIDAY	JADE2	131	Q9NQC1
GDYGEPDYDWTTGPR	KCT2	146	Q8NC54
YQPEGEEGWLYGVVS	KDM3B	206	Q7LBC6
WPNGLALDYDEGKIY	LRP6	491	O75581
PALGGRYFWAVGEEE	LRFN3	276	Q9BTN0
GDYERFGLPGWAVAS	PANK3	256	Q9H999
GDYERFGLPGWAVAS	PANK2	456	Q9BZ23
WLDGSGLGFSLEYPT	CLNS1A	46	P54105
TLYLAPGGGDDWIYD	CPB2	361	Q96IY4
PGGGDDWIYDLGIKY	CPB2	366	Q96IY4
YKAGFGRPDGEYWLG	ANGPTL6	316	Q8NI99
GRPDGEYWLGLEPVY	ANGPTL6	321	Q8NI99
LYGPAILSWEYLSGG	HRH3	166	Q9Y5N1
DFGDLTYGGWKALPL	CEP192	1506	Q8TEP8
DIGWLAEPIFGSGDY	KL	756	Q9UEF7
GKTDFAPGYWYGIEL	CLIP3	436	Q96DZ5
VVTYPCALYGLWDGG	TDRD6	371	O60522
LYAWDDGSPLALLGG	WRAP53	351	Q9BUR4
DCLPYGWEEAYTADG	STXBP4	496	Q6ZWJ1
GLRSYWENVYDEPDG	XYLT1	626	Q86Y38
CGWDKRGPGLYYVDS	PSMB5	161	P28074
GRAYPDVAALSDGYW	TPP1	446	O14773
EYTDWGLLPGSEGAF	KIAA0319	181	Q5VV43
GLISVSYDEWDYGLP	GRIN2B	276	Q13224