Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	Wnt-Frizzled-LRP5/6 complex	LRP6 LRP5	1.04e-04	5	68	2	GO:1990851
MousePheno	abnormal digit morphology	IFT172 GLI3 GKN2 SCUBE3 LRP6 LRP5 TOGARAM1 RAI1	5.34e-06	323	43	8	MP:0002110
MousePheno	abnormal autopod morphology	IFT172 GLI3 GKN2 SCUBE3 LRP6 LRP5 TOGARAM1 RAI1	2.11e-05	390	43	8	MP:0000572
MousePheno	abnormal circulating triglyceride level	ABCA1 ZBTB22 SCUBE3 ABCB11 LRP6 C1QTNF2 GRHL3 PANK1 NUAK2	2.18e-05	516	43	9	MP:0011969
MousePheno	exencephaly	GREB1L IFT172 GLI3 LRP6 GRHL3 NUAK2	6.81e-05	230	43	6	MP:0000914
MousePheno	decreased triglyceride level	ZBTB22 SCUBE3 ABCB11 LRP6 C1QTNF2 GRHL3 PANK1	8.31e-05	348	43	7	MP:0005318
MousePheno	abnormal phalanx morphology	GLI3 SCUBE3 LRP5 RAI1	8.48e-05	76	43	4	MP:0005306
MousePheno	spina bifida cystica	LRP6 GRHL3	9.19e-05	5	43	2	MP:0012547
MousePheno	abnormal triglyceride level	ABCA1 ZBTB22 SCUBE3 ABCB11 LRP6 C1QTNF2 GRHL3 PANK1 NUAK2	1.15e-04	639	43	9	MP:0000187
MousePheno	abnormal ectoderm morphology	GLI3 LRP6 GRHL3	1.26e-04	32	43	3	MP:0014139
MousePheno	abnormal vertebral arch morphology	GLI3 SCUBE3 LRP6 GRHL3 RAI1	1.85e-04	174	43	5	MP:0004599
MousePheno	polyphalangy	GLI3 RAI1	1.92e-04	7	43	2	MP:0000413
MousePheno	decreased liver triglyceride level	ZBTB22 LRP6 C1QTNF2 PANK1	1.94e-04	94	43	4	MP:0009356
MousePheno	decreased lipid level	ABCA1 ZBTB22 SCUBE3 ABCB11 LRP6 C1QTNF2 GRHL3 PANK1 NUAK2	3.03e-04	727	43	9	MP:0014461
MousePheno	abnormal nipple morphology	GLI3 RXFP1	3.28e-04	9	43	2	MP:0006078
MousePheno	decreased body fat mass	ZBTB22 SCUBE3 C1QTNF2	3.75e-04	46	43	3	MP:0014143
MousePheno	abnormal neural tube morphology	GREB1L FAT4 IFT172 GLI3 LRP6 RAD54L2 GRHL3 RAD17	3.81e-04	591	43	8	MP:0002151
MousePheno	digestive/alimentary phenotype	GREB1L NRIP1 FAT4 RELN ABCA1 RIPK1 IFT172 GLI3 NEK8 GKN2 LRP6 GRHL3 NUAK2	3.95e-04	1500	43	13	MP:0005381
MousePheno	abnormal lumbar vertebrae morphology	FAT4 SCUBE3 LRP6 LRP5	4.77e-04	119	43	4	MP:0003049
MousePheno	abnormal femur morphology	SCUBE2 IFT172 GLI3 SCUBE3 LRP5	4.81e-04	214	43	5	MP:0000559
MousePheno	abnormal hindlimb stylopod morphology	SCUBE2 IFT172 GLI3 SCUBE3 LRP5	4.91e-04	215	43	5	MP:0003856
MousePheno	decreased urine uric acid level	OIT3 SCUBE3	5.98e-04	12	43	2	MP:0011424
MousePheno	abnormal vertebral pedicle morphology	SCUBE3 GRHL3	5.98e-04	12	43	2	MP:0004604
MousePheno	decreased heart ventricle size	IFT172 NEK8 SCUBE3	6.03e-04	54	43	3	MP:0031544
MousePheno	abnormal presacral vertebrae morphology	FAT4 SCUBE3 LRP6 LRP5 RAI1	6.04e-04	225	43	5	MP:0000459
MousePheno	short femur	SCUBE2 IFT172 GLI3 SCUBE3	6.10e-04	127	43	4	MP:0003109
MousePheno	polydactyly	IFT172 GLI3 LRP6 TOGARAM1	6.46e-04	129	43	4	MP:0000562
MousePheno	decreased femur size	SCUBE2 IFT172 GLI3 SCUBE3	6.66e-04	130	43	4	MP:0030825
MousePheno	curly tail	FAT4 LRP6 GRHL3	7.07e-04	57	43	3	MP:0003051
MousePheno	abnormal vertebrae development	FAT4 LRP6 RAI1	7.82e-04	59	43	3	MP:0005225
MousePheno	hemorrhage	ABCA1 IFT172 GLI3 NEK8 LRP5 TOGARAM1 GRHL3 RAD17	8.23e-04	664	43	8	MP:0001914
MousePheno	abnormal respiratory system morphology	GREB1L FAT4 ABCA1 IFT172 GLI3 NEK8 ABCB11 LRP6 RXFP1 RAI1	9.00e-04	1027	43	10	MP:0002132
MousePheno	abnormal blood circulation	ABCA1 IFT172 HCN1 GLI3 NEK8 LRP5 TOGARAM1 GRHL3 RAD17	9.05e-04	845	43	9	MP:0002128
MousePheno	abnormal olfactory cortex morphology	RELN GLI3	9.46e-04	15	43	2	MP:0005267
MousePheno	anal atresia	IFT172 GLI3	9.46e-04	15	43	2	MP:0003130
MousePheno	abnormal midbrain-hindbrain boundary morphology	GLI3 LRP6	9.46e-04	15	43	2	MP:0012132
MousePheno	abnormal digestive system morphology	GREB1L NRIP1 FAT4 RELN RIPK1 IFT172 GLI3 GKN2 LRP6 GRHL3 NUAK2	9.83e-04	1233	43	11	MP:0000462
Domain	EGF_CA	FAT4 OIT3 SCUBE2 SCUBE3 LRP5 FBN3	2.24e-06	99	72	6	PS01187
Domain	EGF_3	FAT4 RELN OIT3 SCUBE2 SCUBE3 LRP6 LRP5 FBN3	3.34e-06	235	72	8	PS50026
Domain	EGF	FAT4 RELN OIT3 SCUBE2 SCUBE3 LRP6 LRP5 FBN3	3.34e-06	235	72	8	SM00181
Domain	EGF-like_dom	FAT4 RELN OIT3 SCUBE2 SCUBE3 LRP6 LRP5 FBN3	5.11e-06	249	72	8	IPR000742
Domain	EGF_1	FAT4 RELN OIT3 SCUBE2 SCUBE3 LRP6 LRP5 FBN3	6.09e-06	255	72	8	PS00022
Domain	EGF_2	FAT4 RELN OIT3 SCUBE2 SCUBE3 LRP6 LRP5 FBN3	8.07e-06	265	72	8	PS01186
Domain	EGF-like_Ca-bd_dom	FAT4 OIT3 SCUBE2 SCUBE3 LRP5 FBN3	8.28e-06	124	72	6	IPR001881
Domain	LRP5/6	LRP6 LRP5	1.47e-05	2	72	2	IPR017049
Domain	EGF_Ca-bd_CS	FAT4 OIT3 SCUBE2 SCUBE3 FBN3	3.62e-05	97	72	5	IPR018097
Domain	ASX_HYDROXYL	FAT4 OIT3 SCUBE2 SCUBE3 FBN3	4.19e-05	100	72	5	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	FAT4 OIT3 SCUBE2 SCUBE3 FBN3	5.54e-05	106	72	5	IPR000152
Domain	EGF-like_CS	FAT4 RELN SCUBE2 SCUBE3 LRP6 LRP5 FBN3	6.52e-05	261	72	7	IPR013032
Domain	EGF_CA	FAT4 OIT3 SCUBE2 SCUBE3 FBN3	1.08e-04	122	72	5	SM00179
Domain	EGF	SCUBE2 SCUBE3 LRP6 LRP5 FBN3	1.26e-04	126	72	5	PF00008
Domain	cEGF	SCUBE2 SCUBE3 FBN3	1.34e-04	26	72	3	IPR026823
Domain	cEGF	SCUBE2 SCUBE3 FBN3	1.34e-04	26	72	3	PF12662
Domain	EGF_CA	FAT4 SCUBE2 SCUBE3 FBN3	3.40e-04	86	72	4	PF07645
Domain	-	NHLRC1 LRP6 LRP5	4.54e-04	39	72	3	2.120.10.30
Domain	LDLR_class-A_CS	LRP6 LRP5 RXFP1	4.90e-04	40	72	3	IPR023415
Domain	Ldl_recept_a	LRP6 LRP5 RXFP1	6.94e-04	45	72	3	PF00057
Domain	-	LRP6 LRP5 RXFP1	7.40e-04	46	72	3	4.10.400.10
Domain	6-blade_b-propeller_TolB-like	NHLRC1 LRP6 LRP5	7.40e-04	46	72	3	IPR011042
Domain	Ephrin_rec_like	SCUBE2 SCUBE3	7.88e-04	11	72	2	PF07699
Domain	LDLRA_1	LRP6 LRP5 RXFP1	8.39e-04	48	72	3	PS01209
Domain	LDLRA_2	LRP6 LRP5 RXFP1	8.91e-04	49	72	3	PS50068
Domain	LDrepeatLR_classA_rpt	LRP6 LRP5 RXFP1	8.91e-04	49	72	3	IPR002172
Domain	LDLa	LRP6 LRP5 RXFP1	8.91e-04	49	72	3	SM00192
Domain	EGF_3	SCUBE2 SCUBE3	9.43e-04	12	72	2	PF12947
Domain	EGF_dom	SCUBE2 SCUBE3	9.43e-04	12	72	2	IPR024731
Domain	Ldl_recept_b	LRP6 LRP5	1.29e-03	14	72	2	PF00058
Domain	LDLRB	LRP6 LRP5	1.29e-03	14	72	2	PS51120
Domain	zf-H2C2_2	ZNF846 ZNF345	1.29e-03	14	72	2	PF13465
Domain	LY	LRP6 LRP5	1.49e-03	15	72	2	SM00135
Domain	LDLR_classB_rpt	LRP6 LRP5	1.49e-03	15	72	2	IPR000033
Domain	RCC1	RCC1L NEK8	2.66e-03	20	72	2	PF00415
Domain	ZINC_FINGER_C2H2_2	ZNF608 GLI3 ZNF764 ZNF846 ZBTB22 ZNF227 ZNF853 ZNF512 ZNF345	2.86e-03	775	72	9	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF608 GLI3 ZNF764 ZNF846 ZBTB22 ZNF227 ZNF853 ZNF512 ZNF345	2.91e-03	777	72	9	PS00028
Domain	H2B	H2BC20P H2BC19P	2.94e-03	21	72	2	SM00427
Domain	HISTONE_H2B	H2BC20P H2BC19P	2.94e-03	21	72	2	PS00357
Domain	Histone_H2B	H2BC20P H2BC19P	2.94e-03	21	72	2	IPR000558
Domain	RCC1_1	RCC1L NEK8	2.94e-03	21	72	2	PS00625
Domain	RCC1_2	RCC1L NEK8	2.94e-03	21	72	2	PS00626
Domain	RCC1_3	RCC1L NEK8	2.94e-03	21	72	2	PS50012
Domain	Growth_fac_rcpt_	FAT4 SCUBE2 SCUBE3 FBN3	3.10e-03	156	72	4	IPR009030
Domain	Reg_chr_condens	RCC1L NEK8	3.22e-03	22	72	2	IPR000408
Domain	-	RCC1L NEK8	3.22e-03	22	72	2	2.130.10.30
Domain	Znf_C2H2-like	ZNF608 GLI3 ZNF764 ZNF846 ZBTB22 ZNF227 ZNF853 ZNF512 ZNF345	3.41e-03	796	72	9	IPR015880
Domain	RCC1/BLIP-II	RCC1L NEK8	3.52e-03	23	72	2	IPR009091
Domain	Znf_C2H2	ZNF608 GLI3 ZNF764 ZNF846 ZBTB22 ZNF227 ZNF853 ZNF512 ZNF345	3.67e-03	805	72	9	IPR007087
Domain	ZnF_C2H2	ZNF608 GLI3 ZNF764 ZNF846 ZBTB22 ZNF227 ZNF853 ZNF512 ZNF345	3.76e-03	808	72	9	SM00355
Domain	Keratin_2_head	KRT71 KRT73	3.83e-03	24	72	2	IPR032444
Domain	Keratin_2_head	KRT71 KRT73	3.83e-03	24	72	2	PF16208
Domain	Ephrin_rec_like	SCUBE2 SCUBE3	4.15e-03	25	72	2	SM01411
Domain	Tyr-kin_ephrin_A/B_rcpt-like	SCUBE2 SCUBE3	4.15e-03	25	72	2	IPR011641
Domain	Keratin_II	KRT71 KRT73	4.49e-03	26	72	2	IPR003054
Domain	RICIN	PLA2R1 GALNT6	5.19e-03	28	72	2	SM00458
Domain	hEGF	FAT4 FBN3	5.19e-03	28	72	2	PF12661
Domain	RICIN_B_LECTIN	PLA2R1 GALNT6	5.19e-03	28	72	2	PS50231
Domain	Ricin_B_lectin	PLA2R1 GALNT6	5.95e-03	30	72	2	IPR000772
Pubmed	Evidence against a human cell-specific role for LRP6 in anthrax toxin entry.	LRP6 LRP5	4.23e-06	2	72	2	18350154
Pubmed	Clinical Phenotype and Relevance of LRP5 and LRP6 Variants in Patients With Early-Onset Osteoporosis (EOOP).	LRP6 LRP5	4.23e-06	2	72	2	33118644
Pubmed	Dissecting molecular differences between Wnt coreceptors LRP5 and LRP6.	LRP6 LRP5	4.23e-06	2	72	2	21887268
Pubmed	PAR1&2 driven placenta EVT invasion act via LRP5/6 as coreceptors.	LRP6 LRP5	4.23e-06	2	72	2	33136328
Pubmed	Lack of association of LRP5 and LRP6 polymorphisms with type 2 diabetes mellitus in the Japanese population.	LRP6 LRP5	4.23e-06	2	72	2	18493104
Pubmed	LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way.	LRP6 LRP5	4.23e-06	2	72	2	15084453
Pubmed	Lrp5 and Lrp6 are required for maintaining self-renewal and differentiation of hematopoietic stem cells.	LRP6 LRP5	4.23e-06	2	72	2	30668923
Pubmed	Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts.	LRP6 LRP5	4.23e-06	2	72	2	22433869
Pubmed	Co-deletion of Lrp5 and Lrp6 in the skeleton severely diminishes bone gain from sclerostin antibody administration.	LRP6 LRP5	4.23e-06	2	72	2	33164872
Pubmed	LRP5/6 directly bind to Frizzled and prevent Frizzled-regulated tumour metastasis.	LRP6 LRP5	4.23e-06	2	72	2	25902418
Pubmed	Wnt-Lrp5 signaling regulates fatty acid metabolism in the osteoblast.	LRP6 LRP5	4.23e-06	2	72	2	25802278
Pubmed	The involvement of the canonical Wnt-signaling receptor LRP5 and LRP6 gene variants with ADHD and sexual dimorphism: Association study and meta-analysis.	LRP6 LRP5	4.23e-06	2	72	2	30474181
Pubmed	In Adult Skeletal Muscles, the Co-Receptors of Canonical Wnt Signaling, Lrp5 and Lrp6, Determine the Distribution and Size of Fiber Types, and Structure and Function of Neuromuscular Junctions.	LRP6 LRP5	4.23e-06	2	72	2	36552732
Pubmed	Idiopathic Juvenile Osteoporosis: Clinical Experience from a Single Centre and Screening of LRP5 and LRP6 Genes.	LRP6 LRP5	4.23e-06	2	72	2	25783012
Pubmed	Gene targeting approaches in mice: assessing the roles of LRP5 and LRP6 in osteoblasts.	LRP6 LRP5	4.23e-06	2	72	2	19147944
Pubmed	Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6.	LRP6 LRP5	4.23e-06	2	72	2	15537447
Pubmed	Distinct roles of LRP5 and LRP6 in Wnt signaling regulation in the retina.	LRP6 LRP5	4.23e-06	2	72	2	33545636
Pubmed	LRP5 and LRP6 are not required for protective antigen-mediated internalization or lethality of anthrax lethal toxin.	LRP6 LRP5	4.23e-06	2	72	2	17335347
Pubmed	Scube regulates synovial angiogenesis-related signaling.	SCUBE2 SCUBE3	4.23e-06	2	72	2	24084593
Pubmed	Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density.	LRP6 LRP5	4.23e-06	2	72	2	12579474
Pubmed	The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development.	LRP6 LRP5	4.23e-06	2	72	2	19503830
Pubmed	LRP5-/6 gene polymorphisms and its association with risk of abnormal bone mass in postmenopausal women.	LRP6 LRP5	4.23e-06	2	72	2	37202775
Pubmed	Wnt receptors, bone mass, and fractures: gene-wide association analysis of LRP5 and LRP6 polymorphisms with replication.	LRP6 LRP5	4.23e-06	2	72	2	20926594
Pubmed	Common genetic variation of the low-density lipoprotein receptor-related protein 5 and 6 genes determines fracture risk in elderly white men.	LRP6 LRP5	4.23e-06	2	72	2	16355283
Pubmed	Haemorrhagic snake venom metalloproteases and human ADAMs cleave LRP5/6, which disrupts cell-cell adhesions in vitro and induces haemorrhage in vivo.	LRP6 LRP5	4.23e-06	2	72	2	28425175
Pubmed	Canonical Wnt Signaling in CD11c+ APCs Regulates Microbiota-Induced Inflammation and Immune Cell Homeostasis in the Colon.	LRP6 LRP5	1.27e-05	3	72	2	29602775
Pubmed	Genetic models of mammalian neural tube defects.	GLI3 GRHL3	1.27e-05	3	72	2	8005021
Pubmed	Multivesicular GSK3 sequestration upon Wnt signaling is controlled by p120-catenin/cadherin interaction with LRP5/6.	LRP6 LRP5	1.27e-05	3	72	2	24412065
Pubmed	LRP5 in premature adrenarche and in metabolic characteristics of prepubertal children.	LRP6 LRP5	1.27e-05	3	72	2	18721193
Pubmed	tPA regulates neurite outgrowth by phosphorylation of LRP5/6 in neural progenitor cells.	LRP6 LRP5	1.27e-05	3	72	2	23925701
Pubmed	Structural insight into the mechanisms of Wnt signaling antagonism by Dkk.	LRP6 LRP5	1.27e-05	3	72	2	18524778
Pubmed	The relationship of serum SCUBE-1, -2 and -3 levels with clinical findings and ultrasonographic skin thickness in systemic sclerosis patients.	SCUBE2 SCUBE3	1.27e-05	3	72	2	31991528
Pubmed	Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation.	LRP6 LRP5	1.27e-05	3	72	2	25710911
Pubmed	The structural basis of DKK-mediated inhibition of Wnt/LRP signaling.	LRP6 LRP5	1.27e-05	3	72	2	22589387
Pubmed	Identification of a novel family of cell-surface proteins expressed in human vascular endothelium.	SCUBE2 SCUBE3	1.27e-05	3	72	2	12270931
Pubmed	Wnt co-receptor LRP5/6 overexpression confers protection against hydrogen peroxide-induced neurotoxicity and reduces tau phosphorylation in SH-SY5Y cells.	LRP6 LRP5	1.27e-05	3	72	2	25959626
Pubmed	Opposing Roles of Wnt Inhibitors IGFBP-4 and Dkk1 in Cardiac Ischemia by Differential Targeting of LRP5/6 and β-catenin.	LRP6 LRP5	1.27e-05	3	72	2	27803037
Pubmed	Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/6.	LRP6 LRP5	1.27e-05	3	72	2	21397183
Pubmed	Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6.	LRP6 LRP5	1.27e-05	3	72	2	22000856
Pubmed	Radiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two population-based cohorts.	LRP6 LRP5	1.27e-05	3	72	2	18406176
Pubmed	Specification of osteoblast cell fate by canonical Wnt signaling requires Bmp2.	LRP5 GRHL3	1.27e-05	3	72	2	27802170
Pubmed	Molecular simulation analysis of the structure complex of C2 domains of DKK family members and β-propeller domains of LRP5/6: explaining why DKK3 does not bind to LRP5/6.	LRP6 LRP5	1.27e-05	3	72	2	24743782
Pubmed	Loss of endothelial glucocorticoid receptor promotes angiogenesis via upregulation of Wnt/β-catenin pathway.	LRP6 LRP5	1.27e-05	3	72	2	33650028
Pubmed	Lrp5 and Lrp6 play compensatory roles in mouse intestinal development.	LRP6 LRP5	1.27e-05	3	72	2	21866564
Pubmed	RIP140 triggers foam-cell formation by repressing ABCA1/G1 expression and cholesterol efflux via liver X receptor.	NRIP1 ABCA1	1.27e-05	3	72	2	25616132
Pubmed	Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells.	LRP6 LRP5	1.27e-05	3	72	2	30664649
Pubmed	Peptide-based mediated disruption of N-cadherin-LRP5/6 interaction promotes Wnt signaling and bone formation.	LRP6 LRP5	1.27e-05	3	72	2	22576936
Pubmed	Depletion of canonical Wnt signaling components has a neuroprotective effect on midbrain dopaminergic neurons in an MPTP-induced mouse model of Parkinson's disease.	LRP6 LRP5	1.27e-05	3	72	2	25009587
Pubmed	TRAP1 Regulates Wnt/β-Catenin Pathway through LRP5/6 Receptors Expression Modulation.	LRP6 LRP5	1.27e-05	3	72	2	33065966
Pubmed	Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of Wnt co-receptors.	LRP6 LRP5	2.53e-05	4	72	2	22696217
Pubmed	Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function.	LRP6 LRP5	2.53e-05	4	72	2	21471202
Pubmed	Whole exome sequencing identifies mutations in 10% of patients with familial non-syndromic cleft lip and/or palate in genes mutated in well-known syndromes.	LRP6 GRHL3	2.53e-05	4	72	2	29500247
Pubmed	Lrp5/6 are required for cerebellar development and for suppressing TH expression in Purkinje cells via β-catenin.	LRP6 LRP5	2.53e-05	4	72	2	26772978
Pubmed	The Wnt-β-Catenin-IL-10 Signaling Axis in Intestinal APCs Protects Mice from Colitis-Associated Colon Cancer in Response to Gut Microbiota.	LRP6 LRP5	2.53e-05	4	72	2	32917787
Pubmed	Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts.	LRP6 LRP5	2.53e-05	4	72	2	29176883
Pubmed	Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity.	LRP6 LRP5	2.53e-05	4	72	2	17002572
Pubmed	Oligomerization of Frizzled and LRP5/6 protein initiates intracellular signaling for the canonical WNT/β-catenin pathway.	LRP6 LRP5	2.53e-05	4	72	2	30361437
Pubmed	Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins.	LRP6 LRP5	2.53e-05	4	72	2	15064719
Pubmed	Differential expression of DKK-1 binding receptors on stromal cells and myeloma cells results in their distinct response to secreted DKK-1 in myeloma.	LRP6 LRP5	2.53e-05	4	72	2	20846389
Pubmed	Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism.	LRP6 LRP5	2.53e-05	4	72	2	18502762
Pubmed	Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow.	LRP6 LRP5	2.53e-05	4	72	2	11433302
Pubmed	SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor.	LRP6 LRP5	2.53e-05	4	72	2	15908424
Pubmed	Lrp5 and Lrp6 exert overlapping functions in osteoblasts during postnatal bone acquisition.	LRP6 LRP5	2.53e-05	4	72	2	23675479
Pubmed	Shh Plays an Inhibitory Role in Cusp Patterning by Regulation of Sostdc1.	LRP6 LRP5	2.53e-05	4	72	2	30325689
Pubmed	Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice.	LRP6 LRP5	2.53e-05	4	72	2	31452509
Pubmed	Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation.	LRP6 LRP5	2.53e-05	4	72	2	18762581
Pubmed	K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-specific type II epithelial keratins of the human hair follicle.	KRT71 KRT73	2.53e-05	4	72	2	12648212
Pubmed	The role of Lrp5/6 in cardiac valve disease: experimental hypercholesterolemia in the ApoE-/- /Lrp5-/- mice.	LRP6 LRP5	2.53e-05	4	72	2	21678468
Pubmed	Critical Endothelial Regulation by LRP5 during Retinal Vascular Development.	LRP6 LRP5	2.53e-05	4	72	2	27031698
Pubmed	Characterization of a mouse Scube3 reporter line.	SCUBE2 SCUBE3	2.53e-05	4	72	2	20957652
Pubmed	Hepatocyte growth factor (Hgf) stimulates low density lipoprotein receptor-related protein (Lrp) 5/6 phosphorylation and promotes canonical Wnt signaling.	LRP6 LRP5	4.21e-05	5	72	2	24692544
Pubmed	Scube3 is expressed in multiple tissues during development but is dispensable for embryonic survival in the mouse.	SCUBE2 SCUBE3	4.21e-05	5	72	2	23383134
Pubmed	Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.	LRP6 LRP5	4.21e-05	5	72	2	11448771
Pubmed	Analysis of association of LRP5, LRP6, SOST, DKK1, and CTNNB1 genes with bone mineral density in a Slovenian population.	LRP6 LRP5	4.21e-05	5	72	2	19898734
Pubmed	Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells.	LRP6 LRP5	4.21e-05	5	72	2	16805831
Pubmed	β-catenin signaling in murine liver zonation and regeneration: a Wnt-Wnt situation!	LRP6 LRP5	4.21e-05	5	72	2	24700412
Pubmed	TRAF6 function as a novel co-regulator of Wnt3a target genes in prostate cancer.	LRP6 LRP5	4.21e-05	5	72	2	31262711
Pubmed	The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage.	LRP6 LRP5	4.21e-05	5	72	2	19672307
Pubmed	Role and Regulation of p65/β-Catenin Association During Liver Injury and Regeneration: A "Complex" Relationship.	LRP6 LRP5	4.21e-05	5	72	2	28474571
Pubmed	Negative regulation of LRP6 function by casein kinase I epsilon phosphorylation.	LRP6 LRP5	4.21e-05	5	72	2	16513652
Pubmed	Wnt/β-catenin signaling modulates corneal epithelium stratification via inhibition of Bmp4 during mouse development.	LRP6 LRP5	4.21e-05	5	72	2	26443636
Pubmed	Activation/Proliferation-associated Protein 2 (Caprin-2) Positively Regulates CDK14/Cyclin Y-mediated Lipoprotein Receptor-related Protein 5 and 6 (LRP5/6) Constitutive Phosphorylation.	LRP6 LRP5	4.21e-05	5	72	2	27821587
Pubmed	A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling.	LRP6 LRP5	4.21e-05	5	72	2	12121999
Pubmed	Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling.	LRP6 LRP5	4.21e-05	5	72	2	19107203
Pubmed	LDL-receptor-related proteins in Wnt signal transduction.	LRP6 LRP5	4.21e-05	5	72	2	11029007
Pubmed	Fate Specification of Neural Plate Border by Canonical Wnt Signaling and Grhl3 is Crucial for Neural Tube Closure.	LRP6 LRP5 GRHL3	4.86e-05	34	72	3	26288816
Pubmed	N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation.	LRP6 LRP5	6.31e-05	6	72	2	19075000
Pubmed	Birth-and-death long-term evolution promotes histone H2B variant diversification in the male germinal cell line.	H2BC20P H2BC19P	6.31e-05	6	72	2	20194426
Pubmed	Dickkopf-related protein 1 (Dkk1) regulates the accumulation and function of myeloid derived suppressor cells in cancer.	LRP6 LRP5	6.31e-05	6	72	2	27045006
Pubmed	Balancing WNT signalling in early forebrain development: The role of LRP4 as a modulator of LRP6 function.	LRP6 LRP5	6.31e-05	6	72	2	37091972
Pubmed	Sfrp4 repression of the Ror2/Jnk cascade in osteoclasts protects cortical bone from excessive endosteal resorption.	LRP6 LRP5	6.31e-05	6	72	2	31239337
Pubmed	Macrophage Wnt7b is critical for kidney repair and regeneration.	LRP6 LRP5	6.31e-05	6	72	2	20160075
Pubmed	Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins.	LRP6 LRP5	8.82e-05	7	72	2	12857724
Pubmed	A novel murine allele of Intraflagellar Transport Protein 172 causes a syndrome including VACTERL-like features with hydrocephalus.	IFT172 GLI3	8.82e-05	7	72	2	21653639
Pubmed	Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations.	LRP6 LRP5	8.82e-05	7	72	2	30713111
Pubmed	RSPO2 and RANKL signal through LGR4 to regulate osteoclastic premetastatic niche formation and bone metastasis.	LRP6 LRP5	8.82e-05	7	72	2	34847079
Pubmed	Extracellular LDLR repeats modulate Wnt signaling activity by promoting LRP6 receptor endocytosis mediated by the Itch E3 ubiquitin ligase.	LRP6 LRP5	8.82e-05	7	72	2	28966723
Pubmed	Disruption of Scube2 Impairs Endochondral Bone Formation.	SCUBE2 SCUBE3	8.82e-05	7	72	2	25639508
Pubmed	The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo.	LRP6 LRP5	8.82e-05	7	72	2	19056682
Pubmed	Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5.	LRP6 LRP5	8.82e-05	7	72	2	15923619
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF608 GLI3 ZNF764 ZNF846 ZBTB22 ZNF227 ZNF853 ZNF512 ZNF345	5.73e-05	718	45	9	28
GeneFamily	Low density lipoprotein receptors	LRP6 LRP5	4.64e-04	13	45	2	634
GeneFamily	Zinc fingers C2HC-type\|PHD finger proteins\|Lysine acetyltransferases	NANOS2 L3MBTL1	7.11e-04	16	45	2	66
GeneFamily	Keratins, type II	KRT71 KRT73	2.04e-03	27	45	2	609
GeneFamily	C1-set domain containing	CD1A HLA-DMB	4.90e-03	42	45	2	591
ToppCell	severe-CD4+_T_naive\|severe / disease stage, cell group and cell class	GREB1L L3MBTL1 TLE2 ZNF764 LRP6 KRT73	2.80e-07	167	71	6	02a8215fca59c357c1cdaa5738849eacf98c0bcc
Disease	Nephronophthisis	IFT172 NEK8	2.03e-04	9	71	2	cv:C0687120
Disease	temporal lobe epilepsy (is_marker_for)	RELN HCN1	1.05e-03	20	71	2	DOID:3328 (is_marker_for)
Disease	childhood onset asthma	HLA-DMB SCUBE3 HRNR D2HGDH ITPKA	1.27e-03	334	71	5	MONDO_0005405
Disease	age of onset of childhood onset asthma	SCUBE3 D2HGDH ITPKA	1.44e-03	92	71	3	OBA_2001015
Disease	response to antiviral drug, cirrhosis of liver	MAN1A1 MTCL1	1.52e-03	24	71	2	EFO_0001422, EFO_0010123
Disease	Iniencephaly	GLI3 GRHL3	2.07e-03	28	71	2	C0152234
Disease	Tethered Cord Syndrome	GLI3 GRHL3	2.07e-03	28	71	2	C0080218
Disease	Spinal Cord Myelodysplasia	GLI3 GRHL3	2.07e-03	28	71	2	C0344479
Disease	Exencephaly	GLI3 GRHL3	2.07e-03	28	71	2	C0266453
Disease	Neurenteric Cyst	GLI3 GRHL3	2.07e-03	28	71	2	C0027806
Disease	Acrania	GLI3 GRHL3	2.07e-03	28	71	2	C0702169
Disease	Diastematomyelia	GLI3 GRHL3	2.07e-03	28	71	2	C0011999
Disease	visual perception measurement	OR2L8 CAMTA1 BDH1 HMG20B	2.08e-03	223	71	4	EFO_0009700
Disease	Craniorachischisis	GLI3 GRHL3	2.22e-03	29	71	2	C0152426
Disease	C-reactive protein measurement	ABCA1 ZNF608 IFT172 ABCB11 CEP192 ZNF227 CAMTA1 ZNF853 ZNF512	2.36e-03	1206	71	9	EFO_0004458
Disease	Neural Tube Defects	GLI3 GRHL3	2.38e-03	30	71	2	C0027794

Protein segments in the cluster

Peptide	Gene	Start	Entry
AKASSALVVCGGQGH	ARHGEF10	1326	O15013
GSLGAGGSVHHKCNS	CAMTA1	266	Q9Y6Y1
TGCDSGFGFSLAKHL	BDH1	61	Q02338
GGQVISNGFKVCSSG	ADGRD1	126	Q6QNK2
SNGFKVCSSGGRGSV	ADGRD1	131	Q6QNK2
GSLVQKGHASSCTGN	APOBEC4	76	Q8WW27
CHSGGTCHNLVGGFS	FAT4	3871	Q6V0I7
CFGLLGVNGAGKSST	ABCA1	1941	O95477
GQTLAFVGSSGCGKS	ABCB11	1106	O95342
SSGFGCILAHSMGLG	RAD54L2	296	Q9Y4B4
FRAGQGHCVSGLGFS	FBN3	2641	Q75N90
GTSKGCAFVKFGSQG	CELF6	171	Q96J87
HFSGVGKVRQAACGG	RCC1L	331	Q96I51
VQGGGQGAHSYKSCT	RAI1	226	Q7Z5J4
NKARGYAHCQGGGSS	RAD17	506	O75943
GSHGLGGQTCFSLEM	MTCL1	976	Q9Y4B5
GAPAAHCQGFKSGGL	INPP4A	361	Q96PE3
GSGTSGNAFHEQPCK	GLI3	1236	P10071
AAAKGGFSGCSAVLS	KRT73	11	Q86Y46
AGCFVSKGSFQGHLT	H2BC20P	146	Q6DN03
AGCFVSKGSFQGHLT	H2BC19P	146	Q6DRA6
LAAGFGHSGSQTGCG	ERVS71-1	101	P61550
NGGCSHICIAKGDGT	LRP5	1221	O75197
EGGHYNASSGKFVCG	C1QTNF2	176	Q9BXJ5
TGGCELHSGKVSGSF	CD1A	116	P06126
GCDGSGHVTGKFTAH	L3MBTL1	626	Q9Y468
HGNKSISFTGCGIQS	OR2L8	86	Q8NGY9
NGGCSHSCLGSEKGY	OIT3	231	Q8WWZ8
SYCKGGSNHDGGSSG	HRNR	2811	Q86YZ3
IIMTFGSGSNGCLGH	NEK8	411	Q86SG6
NGGCSHICLVKGDGT	LRP6	1211	O75581
GGSGTAVDKKSAGHN	NRIP1	31	P48552
HGKNALLGFSGNCIG	GREB1L	171	Q9C091
NGGLGTLCNFCKHNG	NANOS2	56	P60321
GAEVSFGCGVLASGK	RELN	731	P78509
NCSGKGILSGHADGT	IFT172	161	Q9UG01
LAGHTGSFKAAGTSG	ITPKA	191	P23677
LSLGCTGAGGFVAHV	HLA-DMB	11	P28068
GGAGAKEHGNSVCFK	HCN1	46	O60741
NTHNVGAGGCAKAGL	GKN2	156	Q86XP6
SNSGVKGCLLSGFRG	GRHL3	426	Q8TE85
VSKGALGLGSCHFTG	GALNT6	556	Q8NCL4
LGLGSCHFTGKNSQV	GALNT6	561	Q8NCL4
GGHSSSLFGNIKGAT	MAN1A1	226	P33908
GKSGLSCQVGSATSH	CEP192	1171	Q8TEP8
CGGGLATKHQGATSF	SCUBE2	731	Q9NQ36
CGGGLTTKHEGAISF	SCUBE3	726	Q8IX30
LASKGFTRAGQGGHS	NIPAL1	96	Q6NVV3
VKIFDSGGGCAHQFG	NHLRC1	151	Q6VVB1
DLGAKGSCHIGGNVA	D2HGDH	191	Q8N465
SLHTTLCATGGGAFK	PANK1	331	Q8TE04
HGSTFQGRKKGGSSF	NXF2	21	Q9GZY0
NTLLNGHKGGDCDGF	HMG20B	166	Q9P0W2
GHSLGLTLGFSHCGN	NUTM2A	96	Q8IVF1
VKCASAGVSSGAGSG	SLAIN1	6	Q8ND83
CSFFKQHAPGGGSTT	NUAK2	351	Q9H093
GGFGKVSLCFHRTQG	RIPK1	26	Q13546
VSNHGLFNIGGSGCL	PLA2R1	76	Q13018
QNLSSGFGHATAGKC	SLCO4A1	556	Q96BD0
SCGTEGFRNAKKGTG	MRPS11	111	P82912
CGKAFSNSSHLIGHG	ZNF846	231	Q147U1
YFSHGGGQDVKCSLG	RXFP1	16	Q9HBX9
GECGKGFSQHSNLVT	ZNF853	516	P0CG23
KSNGGGASPFHCGGT	ZNF608	241	Q9ULD9
VCGKGFSQSSGLQSH	ZNF227	636	Q86WZ6
KECGKAFGSGSNLTH	ZNF345	121	Q14585
DCGKAFGSGSNLTQH	ZNF345	206	Q14585
LGFSQICGKTGSVGS	TOGARAM1	751	Q9Y4F4
DGHKCISCSNGFGGE	WDR31	241	Q8NA23
SGSTQHVYTGGKGCV	TLE2	466	Q04725
SGLKAHLGSCTLGNF	ZNF512	421	Q96ME7
ACGSVAGQIGHFLGC	PTGR2	166	Q8N8N7
GTGSGDGNKIFLCHC	ZBTB22	476	O15209
TDCGKGFGHASSLSK	ZNF764	206	Q96H86
AAAKGGFSGCSAVLS	KRT71	11	Q3SY84