Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	TRPA1 BEST2 RYR2	6.76e-05	33	48	3	GO:0005217
GeneOntologyBiologicalProcess	negative regulation of activated T cell proliferation	BTN2A1 RC3H1 BTN2A3P	1.23e-05	20	47	3	GO:0046007
GeneOntologyBiologicalProcess	cellular response to indole-3-methanol	JUP CTNNB1	5.06e-05	5	47	2	GO:0071681
GeneOntologyBiologicalProcess	response to indole-3-methanol	JUP CTNNB1	7.58e-05	6	47	2	GO:0071680
GeneOntologyBiologicalProcess	negative regulation of lymphocyte proliferation	PKN1 BTN2A1 RC3H1 BTN2A3P	1.82e-04	124	47	4	GO:0050672
GeneOntologyBiologicalProcess	negative regulation of mononuclear cell proliferation	PKN1 BTN2A1 RC3H1 BTN2A3P	1.93e-04	126	47	4	GO:0032945
GeneOntologyBiologicalProcess	T cell differentiation	JAK1 CTNNB1 SOX13 BTN2A1 RC3H1 BTN2A3P	2.19e-04	382	47	6	GO:0030217
GeneOntologyBiologicalProcess	negative regulation of leukocyte proliferation	PKN1 BTN2A1 RC3H1 BTN2A3P	2.45e-04	134	47	4	GO:0070664
GeneOntologyBiologicalProcess	regulation of activated T cell proliferation	BTN2A1 RC3H1 BTN2A3P	2.54e-04	54	47	3	GO:0046006
GeneOntologyBiologicalProcess	regulation of T cell receptor signaling pathway	BTN2A1 RC3H1 BTN2A3P	2.68e-04	55	47	3	GO:0050856
GeneOntologyBiologicalProcess	regulation of germinal center formation	PKN1 RC3H1	2.76e-04	11	47	2	GO:0002634
GeneOntologyCellularComponent	extrinsic component of plasma membrane	JAK1 JUP CTNNB1 CUBN RYR2	1.53e-05	137	48	5	GO:0019897
GeneOntologyCellularComponent	catenin-TCF7L2 complex	JUP CTNNB1	3.09e-05	4	48	2	GO:0071664
GeneOntologyCellularComponent	extrinsic component of membrane	JAK1 JUP CTNNB1 CUBN RYR2	1.80e-04	230	48	5	GO:0019898
GeneOntologyCellularComponent	hemidesmosome	JUP DST	2.80e-04	11	48	2	GO:0030056
GeneOntologyCellularComponent	fascia adherens	JUP CTNNB1	3.96e-04	13	48	2	GO:0005916
GeneOntologyCellularComponent	Z disc	JUP CTNNB1 DST RYR2	3.98e-04	151	48	4	GO:0030018
GeneOntologyCellularComponent	intercalated disc	JUP CTNNB1 DST	5.13e-04	68	48	3	GO:0014704
GeneOntologyCellularComponent	I band	JUP CTNNB1 DST RYR2	5.68e-04	166	48	4	GO:0031674
GeneOntologyCellularComponent	side of membrane	JAK1 JUP DST CUBN BTN2A1 RYR2 GSR BTN2A3P	7.78e-04	875	48	8	GO:0098552
GeneOntologyCellularComponent	cytoplasmic side of plasma membrane	JAK1 JUP DST RYR2	8.53e-04	185	48	4	GO:0009898
GeneOntologyCellularComponent	cell-cell contact zone	JUP CTNNB1 DST	1.32e-03	94	48	3	GO:0044291
GeneOntologyCellularComponent	apicolateral plasma membrane	JUP CTNNB1	1.88e-03	28	48	2	GO:0016327
GeneOntologyCellularComponent	cytoplasmic side of membrane	JAK1 JUP DST RYR2	1.90e-03	230	48	4	GO:0098562
GeneOntologyCellularComponent	catenin complex	JUP CTNNB1	2.45e-03	32	48	2	GO:0016342
GeneOntologyCellularComponent	sarcomere	JUP CTNNB1 DST RYR2	2.53e-03	249	48	4	GO:0030017
GeneOntologyCellularComponent	microvillus membrane	CTNNB1 CUBN	3.44e-03	38	48	2	GO:0031528
GeneOntologyCellularComponent	myofibril	JUP CTNNB1 DST RYR2	3.53e-03	273	48	4	GO:0030016
GeneOntologyCellularComponent	contractile muscle fiber	JUP CTNNB1 DST RYR2	4.37e-03	290	48	4	GO:0043292
MousePheno	increased anti-nuclear antigen antibody level	JAK1 PKN1 BTN2A1 RC3H1 BTN2A3P	1.40e-05	115	38	5	MP:0004794
MousePheno	increased autoantibody level	JAK1 PKN1 BTN2A1 RC3H1 BTN2A3P	2.82e-05	133	38	5	MP:0003725
MousePheno	increased IgG1 level	JAK1 PKN1 BTN2A1 BTN2A3P	7.31e-05	83	38	4	MP:0008499
MousePheno	increased response to antigen	BTN2A1 BTN2A3P	1.07e-04	6	38	2	MP:0020002
MousePheno	increased IgG2 level	JAK1 PKN1 BTN2A1 BTN2A3P	1.45e-04	99	38	4	MP:0013803
MousePheno	increased immunoglobulin level	JAK1 NLRP1 PKN1 BTN2A1 RC3H1 BTN2A3P	1.57e-04	305	38	6	MP:0002461
MousePheno	increased IgG level	JAK1 PKN1 BTN2A1 RC3H1 BTN2A3P	2.00e-04	201	38	5	MP:0002493
Domain	Beta-catenin	JUP CTNNB1	6.47e-06	2	48	2	IPR013284
Domain	ANK	POTEB2 TRPA1 ANKHD1 POTEB TONSL	4.50e-04	251	48	5	SM00248
Domain	ANK_REPEAT	POTEB2 TRPA1 ANKHD1 POTEB TONSL	4.67e-04	253	48	5	PS50088
Domain	Ankyrin_rpt-contain_dom	POTEB2 TRPA1 ANKHD1 POTEB TONSL	4.75e-04	254	48	5	IPR020683
Domain	ANK_REP_REGION	POTEB2 TRPA1 ANKHD1 POTEB TONSL	4.75e-04	254	48	5	PS50297
Domain	Ankyrin_rpt	POTEB2 TRPA1 ANKHD1 POTEB TONSL	5.47e-04	262	48	5	IPR002110
Domain	SPRY	BTN2A1 RYR2 BTN2A3P	1.45e-03	87	48	3	SM00449
Domain	-	NLRP1 DEDD2 UNC5CL	1.76e-03	93	48	3	1.10.533.10
Domain	SPRY	BTN2A1 RYR2 BTN2A3P	1.81e-03	94	48	3	PF00622
Domain	SPRY_dom	BTN2A1 RYR2 BTN2A3P	1.81e-03	94	48	3	IPR003877
Domain	B30.2/SPRY	BTN2A1 RYR2 BTN2A3P	1.87e-03	95	48	3	IPR001870
Domain	B302_SPRY	BTN2A1 RYR2 BTN2A3P	1.87e-03	95	48	3	PS50188
Domain	DEATH-like_dom	NLRP1 DEDD2 UNC5CL	2.10e-03	99	48	3	IPR011029
Domain	-	RANBP6 JUP CTNNB1 CUL7	2.51e-03	222	48	4	1.25.10.10
Domain	Ank	TRPA1 ANKHD1 POTEB TONSL	2.76e-03	228	48	4	PF00023
Domain	Arm	JUP CTNNB1	2.87e-03	31	48	2	PF00514
Domain	ARM_REPEAT	JUP CTNNB1	4.74e-03	40	48	2	PS50176
Domain	ARM	JUP CTNNB1	4.74e-03	40	48	2	SM00185
Domain	ARM-like	RANBP6 JUP CTNNB1 CUL7	5.05e-03	270	48	4	IPR011989
Domain	Armadillo	JUP CTNNB1	6.49e-03	47	48	2	IPR000225
Domain	PRY	BTN2A1 BTN2A3P	6.77e-03	48	48	2	SM00589
Domain	HEAT	RANBP6 JUP	6.77e-03	48	48	2	PF02985
Domain	PRY	BTN2A1 BTN2A3P	6.77e-03	48	48	2	IPR006574
Domain	Znf_RING_CS	PCGF5 PDZRN3 RC3H1	8.47e-03	163	48	3	IPR017907
Domain	LRR_6	NLRP1 TONSL	8.81e-03	55	48	2	PF13516
Domain	HEAT	RANBP6 JUP	9.76e-03	58	48	2	IPR000357
Pathway	REACTOME_REGULATION_OF_CDH19_EXPRESSION_AND_FUNCTION	JUP CTNNB1	9.13e-05	7	30	2	M48017
Pathway	REACTOME_CDH11_HOMOTYPIC_AND_HETEROTYPIC_INTERACTIONS	JUP CTNNB1	9.13e-05	7	30	2	M48038
Pathway	REACTOME_REGULATION_OF_CDH11_FUNCTION	JUP CTNNB1	1.22e-04	8	30	2	MM17072
Pathway	REACTOME_BUTYROPHILIN_BTN_FAMILY_INTERACTIONS	BTN2A1 BTN2A3P	1.56e-04	9	30	2	MM15487
Pathway	REACTOME_REGULATION_OF_CDH11_FUNCTION	JUP CTNNB1	2.38e-04	11	30	2	M48015
Pathway	REACTOME_REGULATION_OF_CDH11_EXPRESSION_AND_FUNCTION	JUP CTNNB1	2.85e-04	12	30	2	MM17071
Pathway	REACTOME_VITAMIN_D_CALCIFEROL_METABOLISM	CUBN CYP24A1	2.85e-04	12	30	2	M27088
Pathway	REACTOME_CELL_JUNCTION_ORGANIZATION	JUP CTNNB1 DST	4.89e-04	73	30	3	MM15126
Pathway	WP_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY	JUP CTNNB1 RYR2	5.09e-04	74	30	3	M39462
Pathway	KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC	JUP CTNNB1 RYR2	5.09e-04	74	30	3	M16376
Pubmed	Localization of antigens associated with adherens junctions, desmosomes, and hemidesmosomes during murine molar morphogenesis.	JUP CTNNB1 DST	4.92e-08	6	48	3	9615388
Pubmed	γ-Catenin at adherens junctions: mechanism and biologic implications in hepatocellular cancer after β-catenin knockdown.	JUP CTNNB1	1.87e-06	2	48	2	23555187
Pubmed	A knock-in mouse model of N-terminal R420W mutation of cardiac ryanodine receptor exhibits arrhythmogenesis with abnormal calcium dynamics in cardiomyocytes.	RC3H1 RYR2	1.87e-06	2	48	2	25193700
Pubmed	Ectopic γ-catenin expression partially mimics the effects of stabilized β-catenin on embryonic stem cell differentiation.	JUP CTNNB1	1.87e-06	2	48	2	23724138
Pubmed	Plakoglobin and beta-catenin: distinct but closely related.	JUP CTNNB1	1.87e-06	2	48	2	1509266
Pubmed	Regulation of endothelial cell adherens junctions by a Ras-dependent signal transduction pathway.	JUP CTNNB1	1.87e-06	2	48	2	10403777
Pubmed	Defining the roles of beta-catenin and plakoglobin in LEF/T-cell factor-dependent transcription using beta-catenin/plakoglobin-null F9 cells.	JUP CTNNB1	1.87e-06	2	48	2	17984222
Pubmed	Hepatocyte γ-catenin compensates for conditionally deleted β-catenin at adherens junctions.	JUP CTNNB1	1.87e-06	2	48	2	21703193
Pubmed	The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties.	JUP CTNNB1	1.87e-06	2	48	2	1639851
Pubmed	Mice with Hepatic Loss of the Desmosomal Protein γ-Catenin Are Prone to Cholestatic Injury and Chemical Carcinogenesis.	JUP CTNNB1	1.87e-06	2	48	2	26485505
Pubmed	Defining the roles of beta-catenin and plakoglobin in cell-cell adhesion: isolation of beta-catenin/plakoglobin-deficient F9 cells.	JUP CTNNB1	1.87e-06	2	48	2	16357441
Pubmed	Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin.	JUP CTNNB1	1.87e-06	2	48	2	17906078
Pubmed	Simultaneous loss of beta- and gamma-catenin does not perturb hematopoiesis or lymphopoiesis.	JUP CTNNB1	1.87e-06	2	48	2	17855627
Pubmed	Downregulation of γ-catenin inhibits CML cell growth and potentiates the response of CML cells to imatinib through β-catenin inhibition.	JUP CTNNB1	1.87e-06	2	48	2	23233089
Pubmed	Expression of β-catenin and γ-catenin in maxillary bone regeneration.	JUP CTNNB1	1.87e-06	2	48	2	21781455
Pubmed	Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin.	JUP CTNNB1	5.59e-06	3	48	2	10825188
Pubmed	Cellular redistribution of protein tyrosine phosphatases LAR and PTPsigma by inducible proteolytic processing.	JUP CTNNB1	5.59e-06	3	48	2	9245795
Pubmed	Butyrophilin 2a2 (Btn2a2) expression on thymic epithelial cells promotes central T cell tolerance and prevents autoimmune disease.	BTN2A1 BTN2A3P	5.59e-06	3	48	2	37356345
Pubmed	Upregulation of gamma-catenin compensates for the loss of beta-catenin in adult cardiomyocytes.	JUP CTNNB1	5.59e-06	3	48	2	16936006
Pubmed	Synergistic control of keratinocyte adhesion through muscarinic and nicotinic acetylcholine receptor subtypes.	JUP CTNNB1	5.59e-06	3	48	2	15023540
Pubmed	Suppression of canonical Wnt/beta-catenin signaling by nuclear plakoglobin recapitulates phenotype of arrhythmogenic right ventricular cardiomyopathy.	JUP CTNNB1	5.59e-06	3	48	2	16823493
Pubmed	RANKL-Induced Btn2a2 - A T Cell Immunomodulatory Molecule - During Osteoclast Differentiation Fine-Tunes Bone Resorption.	BTN2A1 BTN2A3P	5.59e-06	3	48	2	34421818
Pubmed	Association of human protein-tyrosine phosphatase kappa with members of the armadillo family.	JUP CTNNB1	5.59e-06	3	48	2	8663237
Pubmed	Different effects of dominant negative mutants of desmocollin and desmoglein on the cell-cell adhesion of keratinocytes.	JUP CTNNB1	5.59e-06	3	48	2	10769211
Pubmed	Cardiac tissue-restricted deletion of plakoglobin results in progressive cardiomyopathy and activation of {beta}-catenin signaling.	JUP CTNNB1	5.59e-06	3	48	2	21245375
Pubmed	Interaction of the DF3/MUC1 breast carcinoma-associated antigen and beta-catenin in cell adhesion.	JUP CTNNB1	5.59e-06	3	48	2	9139698
Pubmed	Identification of the domain of alpha-catenin involved in its association with beta-catenin and plakoglobin (gamma-catenin).	JUP CTNNB1	5.59e-06	3	48	2	9110993
Pubmed	c-erbB-2 gene product directly associates with beta-catenin and plakoglobin.	JUP CTNNB1	5.59e-06	3	48	2	7702605
Pubmed	Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex.	JUP CTNNB1	5.59e-06	3	48	2	11707392
Pubmed	Catenin expression in T1/2 carcinomas of the floor of the mouth.	JUP CTNNB1	5.59e-06	3	48	2	15916880
Pubmed	Identification of the regions of PECAM-1 involved in beta- and gamma-catenin associations.	JUP CTNNB1	5.59e-06	3	48	2	15766557
Pubmed	CBP/Catenin antagonists: Targeting LSCs' Achilles heel.	JUP CTNNB1	5.59e-06	3	48	2	28479420
Pubmed	Plakoglobin restores tumor suppressor activity of p53R175H mutant by sequestering the oncogenic potential of β-catenin.	JUP CTNNB1	5.59e-06	3	48	2	29660231
Pubmed	A mutation in alpha-catenin disrupts adhesion in clone A cells without perturbing its actin and beta-catenin binding activity.	JUP CTNNB1	5.59e-06	3	48	2	9762469
Pubmed	The Barrier Molecules Junction Plakoglobin, Filaggrin, and Dystonin Play Roles in Melanoma Growth and Angiogenesis.	JUP DST	5.59e-06	3	48	2	31425296
Pubmed	Three-dimensional structure of the armadillo repeat region of beta-catenin.	JUP CTNNB1	5.59e-06	3	48	2	9298899
Pubmed	Btn2a2 Regulates ILC2-T Cell Cross Talk in Type 2 Immune Responses.	BTN2A1 BTN2A3P	1.12e-05	4	48	2	35145516
Pubmed	Distinct location and prevalence of alpha-, beta-catenins and gamma-catenin/plakoglobin in developing and denervated skeletal muscle.	JUP CTNNB1	1.12e-05	4	48	2	9638336
Pubmed	Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin.	JUP CTNNB1	1.12e-05	4	48	2	7650039
Pubmed	Crystal structure of a beta-catenin/Tcf complex.	JUP CTNNB1	1.12e-05	4	48	2	11136974
Pubmed	Multiple post-translational modifications regulate E-cadherin transport during apoptosis.	JUP CTNNB1	1.12e-05	4	48	2	22375065
Pubmed	Mammalian formin-1 participates in adherens junctions and polymerization of linear actin cables.	JUP CTNNB1	1.12e-05	4	48	2	14647292
Pubmed	Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion.	JUP CTNNB1	1.12e-05	4	48	2	7982500
Pubmed	Axin directly interacts with plakoglobin and regulates its stability.	JUP CTNNB1	1.12e-05	4	48	2	10488109
Pubmed	Association of p120, a tyrosine kinase substrate, with E-cadherin/catenin complexes.	JUP CTNNB1	1.12e-05	4	48	2	7876318
Pubmed	Butyrophilin Btn2a2 inhibits TCR activation and phosphatidylinositol 3-kinase/Akt pathway signaling and induces Foxp3 expression in T lymphocytes.	BTN2A1 BTN2A3P	1.12e-05	4	48	2	23589618
Pubmed	Alteration of interendothelial adherens junctions following tumor cell-endothelial cell interaction in vitro.	JUP CTNNB1	1.12e-05	4	48	2	9434630
Pubmed	β-catenin coordinates with Jup and the TCF1/GATA6 axis to regulate human embryonic stem cell fate.	JUP CTNNB1	1.12e-05	4	48	2	28943339
Pubmed	Reduced expression of E-cadherin/catenin complex in hepatocellular carcinomas.	JUP CTNNB1	1.12e-05	4	48	2	18837082
Pubmed	The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin.	JUP CTNNB1	1.12e-05	4	48	2	11348595
Pubmed	Expression of the E-cadherin-catenin complex in patients with pancreatic ductal adenocarcinoma.	JUP CTNNB1	1.12e-05	4	48	2	20529828
Pubmed	The expression of E-cadherin-catenin complex in patients with advanced gastric cancer: role in formation of metastasis.	JUP CTNNB1	1.12e-05	4	48	2	20529814
Pubmed	CBP/catenin antagonist safely eliminates drug-resistant leukemia-initiating cells.	JUP CTNNB1	1.12e-05	4	48	2	26657156
Pubmed	Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart.	JUP CTNNB1	1.12e-05	4	48	2	8858175
Pubmed	Altered expression of cell adhesion molecules leads to differential uptake of hypericin in urothelial cancer.	JUP CTNNB1	1.12e-05	4	48	2	20933443
Pubmed	Homeostatic pruning and activity of epidermal nerves are dysregulated in barrier-impaired skin during chronic itch development.	JAK1 TRPA1	1.12e-05	4	48	2	31197234
Pubmed	Btn2a2, a T cell immunomodulatory molecule coregulated with MHC class II genes.	BTN2A1 BTN2A3P	1.12e-05	4	48	2	26809444
Pubmed	Combining Unique Multiplex Gateway Cloning and Bimolecular Fluorescence Complementation (BiFC) for High-Throughput Screening of Protein-Protein Interactions.	PUS7L AHCY	1.12e-05	4	48	2	27455993
Pubmed	Tyrosine phosphorylation regulates the adhesions of ras-transformed breast epithelia.	JUP CTNNB1	1.86e-05	5	48	2	7542250
Pubmed	Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes.	JUP CTNNB1	1.86e-05	5	48	2	10868478
Pubmed	Amino-terminal domain of classic cadherins determines the specificity of the adhesive interactions.	JUP CTNNB1	1.86e-05	5	48	2	10910767
Pubmed	N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane.	JUP CTNNB1	1.86e-05	5	48	2	12604612
Pubmed	Mutations in the area composita protein αT-catenin are associated with arrhythmogenic right ventricular cardiomyopathy.	JUP CTNNB1	1.86e-05	5	48	2	23136403
Pubmed	The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin.	JUP CTNNB1	1.86e-05	5	48	2	7890674
Pubmed	Histamine stimulates phosphorylation of adherens junction proteins and alters their link to vimentin.	JUP CTNNB1	1.86e-05	5	48	2	12003790
Pubmed	Loss of cadherin-binding proteins β-catenin and plakoglobin in the heart leads to gap junction remodeling and arrhythmogenesis.	JUP CTNNB1	1.86e-05	5	48	2	22252313
Pubmed	Polycystin: new aspects of structure, function, and regulation.	JUP CTNNB1	1.86e-05	5	48	2	11274246
Pubmed	The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species.	JUP CTNNB1	1.86e-05	5	48	2	2788574
Pubmed	Expression and interaction of different catenins in colorectal carcinoma cells.	JUP CTNNB1	1.86e-05	5	48	2	11712088
Pubmed	Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule.	JUP CTNNB1	1.86e-05	5	48	2	2349235
Pubmed	Pleiotrophin disrupts calcium-dependent homophilic cell-cell adhesion and initiates an epithelial-mesenchymal transition.	JUP CTNNB1	2.79e-05	6	48	2	17098867
Pubmed	Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex.	JUP CTNNB1	2.79e-05	6	48	2	11226248
Pubmed	Two novel transcripts encoding two Ankyrin repeat containing proteins have preponderant expression during the mouse spermatogenesis.	POTEB2 POTEB	2.79e-05	6	48	2	17171436
Pubmed	BTN1A1, the mammary gland butyrophilin, and BTN2A2 are both inhibitors of T cell activation.	BTN2A1 BTN2A3P	2.79e-05	6	48	2	20208008
Pubmed	γ-Catenin-Dependent Signals Maintain BCR-ABL1+ B Cell Acute Lymphoblastic Leukemia.	JUP CTNNB1	2.79e-05	6	48	2	30991025
Pubmed	Cadherin-dependent adhesion is required for muscle stem cell niche anchorage and maintenance.	JUP CTNNB1	2.79e-05	6	48	2	38456551
Pubmed	Lack of beta-catenin affects mouse development at gastrulation.	JUP CTNNB1	2.79e-05	6	48	2	8582267
Pubmed	Plakoglobin is a mechanoresponsive regulator of naive pluripotency.	JUP CTNNB1	2.79e-05	6	48	2	37419903
Pubmed	Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo.	RANBP6 JUP CUBN PDZRN3 PEG3 AHCY	2.80e-05	432	48	6	7671812
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	JAK1 PKN1 CTNNB1 DST CUL7 DDX41 PCGF5 AHCY	3.18e-05	910	48	8	36736316
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	JUP IRS4 CTNNB1 DDX41 RC3H1	3.80e-05	274	48	5	34244482
Pubmed	Vitamin D.	CUBN CYP24A1	3.90e-05	7	48	2	15951480
Pubmed	The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin.	JUP CTNNB1	3.90e-05	7	48	2	12808048
Pubmed	Expression and cell membrane localization of catenins during mouse preimplantation development.	JUP CTNNB1	3.90e-05	7	48	2	8853988
Pubmed	The cell adhesion molecule M-cadherin is not essential for muscle development and regeneration.	JUP CTNNB1	3.90e-05	7	48	2	12052883
Pubmed	β-catenin and γ-catenin are dispensable for T lymphocytes and AML leukemic stem cells.	JUP CTNNB1	3.90e-05	7	48	2	32820720
Pubmed	The cluster of BTN genes in the extended major histocompatibility complex.	BTN2A1 BTN2A3P	3.90e-05	7	48	2	11170752
Pubmed	Gamma-secretase-dependent and -independent effects of presenilin1 on beta-catenin.Tcf-4 transcriptional activity.	JUP CTNNB1	3.90e-05	7	48	2	19114997
Pubmed	The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn).	JUP CTNNB1	3.90e-05	7	48	2	12370829
Pubmed	Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation.	JUP CTNNB1	3.90e-05	7	48	2	15479741
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	JUP IRS4 DST DDX41 SHKBP1 AHCY	4.86e-05	477	48	6	31300519
Pubmed	Cell-matrix interactions and cell-cell junctions during epithelial histo-morphogenesis in the developing mouse incisor.	JUP DST	5.19e-05	8	48	2	11669375
Pubmed	Functional analysis of ectodermal β-catenin during external genitalia formation.	JUP CTNNB1	5.19e-05	8	48	2	23480356
Pubmed	POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer.	POTEB2 POTEB	5.19e-05	8	48	2	12475935
Pubmed	Platelet-endothelial cell adhesion molecule-1 (CD31), a scaffolding molecule for selected catenin family members whose binding is mediated by different tyrosine and serine/threonine phosphorylation.	JUP CTNNB1	5.19e-05	8	48	2	10801826
Pubmed	The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton.	JUP CTNNB1	5.19e-05	8	48	2	9535896
Pubmed	Cell-junctional and cytoskeletal organization in mouse blastocysts lacking E-cadherin.	JUP CTNNB1	5.19e-05	8	48	2	9187087
Pubmed	The genes coding for alpha and beta catenin (Catna1 and Catnb) and plakoglobin (Jup) map to mouse chromosomes 18, 9, and 11, respectively.	JUP CTNNB1	5.19e-05	8	48	2	7626889
Pubmed	beta-Catenin protects the epidermis from mechanical stresses.	JUP CTNNB1	6.67e-05	9	48	2	23816618
Pubmed	Expression of catenins during mouse embryonic development and in adult tissues.	JUP CTNNB1	6.67e-05	9	48	2	8821035
Interaction	H2AC19 interactions	CUL7 RC3H1 PARP2 TONSL	6.02e-06	50	48	4	int:H2AC19
Interaction	DCAF8L1 interactions	CUL7 DCAF8L1	1.66e-05	3	48	2	int:DCAF8L1
GeneFamily	Ankyrin repeat domain containing	POTEB2 TRPA1 ANKHD1 POTEB TONSL	8.35e-05	242	34	5	403
GeneFamily	Ankyrin repeat domain containing\|POTE ankyrin domain containing	POTEB2 POTEB	2.64e-04	13	34	2	685
GeneFamily	Butyrophilins\|V-set domain containing\|C2-set domain containing	BTN2A1 BTN2A3P	3.55e-04	15	34	2	458
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	JUP CTNNB1	2.95e-03	43	34	2	409
GeneFamily	WD repeat domain containing	DMXL2 DCAF8L1 SHKBP1	1.29e-02	262	34	3	362
GeneFamily	Ring finger proteins	PCGF5 PDZRN3 RC3H1	1.47e-02	275	34	3	58
ToppCell	droplet-Lung-LUNG-30m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DMXL2 SLC9A4 CTNNB1 DST	4.29e-05	181	48	4	8fcdab61fad2efd324d2b27c58f5a594f1dc15de
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DMXL2 SLC9A4 CTNNB1 DST	4.39e-05	182	48	4	be48ce85991bceeff938ba080e6bf9cc62176b05
ToppCell	droplet-Lung-nan-21m-Myeloid-alveolar_macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DMXL2 SLC9A4 CTNNB1 DST	4.77e-05	186	48	4	8f77e552e613b6e124443c7f6ef5c1316a5ff8db
ToppCell	droplet-Lung-nan-21m-Myeloid-Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DMXL2 SLC9A4 CTNNB1 DST	4.77e-05	186	48	4	f1aa0c58336d23bcbe52a59e7af954d20085bdb6
ToppCell	droplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DMXL2 SLC9A4 CTNNB1 DST	5.08e-05	189	48	4	98f517af255ef234eefc3ed7e6c1d63331ab8af0
ToppCell	droplet-Lung-1m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DMXL2 SLC9A4 CTNNB1 DST	5.08e-05	189	48	4	b2542b6fcf7bc10d29158d42b03182a939ff135a
ToppCell	droplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DMXL2 SLC9A4 CTNNB1 DST	5.08e-05	189	48	4	f7e9b6e6a4de297b660a5b6c9a62f860c147185e
ToppCell	droplet-Lung-1m-Hematologic-myeloid-alveolar_macrophage\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DMXL2 SLC9A4 CTNNB1 DST	5.18e-05	190	48	4	da58227565ad6a690828dd8554dd3670222f8582
ToppCell	COVID-19_Mild-Classical_Monocyte-cMono_4\|COVID-19_Mild / Disease condition and Cell class	RBP7 DMXL2 JUP CTNNB1	5.85e-05	196	48	4	3729d1444c65cad640377894decc64129bc3fd5b
ToppCell	facs-Skin-Telogen-3m-Epithelial-bulge_keratinocyte\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CTNNB1 DST PDZRN3 PEG3	5.85e-05	196	48	4	90edf61116ffcb4f8b6be3d0a05732d59b0a87d5
ToppCell	facs-Skin-Telogen-3m-Epithelial-outer_bulge\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CTNNB1 DST PDZRN3 PEG3	5.85e-05	196	48	4	c936014125b2ed5f796221b74acb77b8f8359875
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	JUP DST CYP24A1 AHCY	6.20e-05	199	48	4	4099df3c052a9536d72ba01492317be7d83a79ad
ToppCell	Bronchial_Biopsy-Epithelial-Basal_2\|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X	JUP DST CYP24A1 AHCY	6.33e-05	200	48	4	99997c447f2b59324fe69c17593db72d972c0cc4
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2-Th.Nr4a2_(MGE-derived_cortical_interneurons)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	RBP7 UNC5CL CYP24A1	7.29e-05	75	48	3	6339b514a98511e409d86d4b9d460afe192557c0
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2-Th.Nr4a2_(MGE-derived_cortical_interneurons)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	RBP7 UNC5CL CYP24A1	7.29e-05	75	48	3	a5bef117c483ce5afc38d96709370e8e53f4f2a9
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2-Th.Nr4a2_(MGE-derived_cortical_interneurons)--\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	RBP7 UNC5CL CYP24A1	7.29e-05	75	48	3	75181a17aca2482f18f23beb31983d01043e02cb
Drug	SB216763	JAK1 NLRP1 PKN1 CTNNB1	1.26e-06	40	46	4	CID000176158
Drug	miripirium chloride	NLRP1 PRSS45P RTCA AHCY	5.71e-06	58	46	4	CID000017671
Drug	genistein	JAK1 NLRP1 PKN1 CTNNB1 DST TRPA1 DDX41 RYR2 CYP24A1 GSR TONSL	1.03e-05	1117	46	11	CID005280961
Disease	No-Reflow Phenomenon	JUP CTNNB1	6.22e-06	3	43	2	C0232347
Disease	Slow-Flow Phenomenon	JUP CTNNB1	6.22e-06	3	43	2	C2713615
Disease	colorectal cancer (biomarker_via_orthology)	HK1 CTNNB1	3.10e-05	6	43	2	DOID:9256 (biomarker_via_orthology)
Disease	urinary bladder cancer (implicated_via_orthology)	HK1 CTNNB1	7.42e-05	9	43	2	DOID:11054 (implicated_via_orthology)
Disease	ovarian cancer (is_implicated_in)	JAK1 JUP CTNNB1	7.57e-05	56	43	3	DOID:2394 (is_implicated_in)
Disease	Enzymopathy	HK1 GSR	1.13e-04	11	43	2	C0520572
Disease	R-6-hydroxywarfarin to R-warfarin ratio measurement	HK1 SOX13 AHCY	5.01e-04	106	43	3	EFO_0803333
Disease	cancer (implicated_via_orthology)	RANBP6 JUP CTNNB1 DST	6.22e-04	268	43	4	DOID:162 (implicated_via_orthology)
Disease	colorectal cancer (is_implicated_in)	JAK1 CTNNB1 CYP24A1	7.36e-04	121	43	3	DOID:9256 (is_implicated_in)
Disease	glucose metabolism disease (implicated_via_orthology)	IRS4 HK1	7.65e-04	28	43	2	DOID:4194 (implicated_via_orthology)
Disease	renal cell carcinoma (is_marker_for)	JUP CTNNB1 GSR	8.67e-04	128	43	3	DOID:4450 (is_marker_for)
Disease	lung non-small cell carcinoma (is_implicated_in)	JAK1 MSH5 CYP24A1	1.10e-03	139	43	3	DOID:3908 (is_implicated_in)
Disease	nephroblastoma (is_marker_for)	JUP CTNNB1	1.13e-03	34	43	2	DOID:2154 (is_marker_for)
Disease	heart disease (implicated_via_orthology)	SOX13 RYR2	1.41e-03	38	43	2	DOID:114 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
MRDHEDGGIQLECIS	BTN2A3P	151	Q96KV6
LMCVVAGTVHGRDDR	BEST2	106	Q8NFU1
EEKVVGIHMQGLGCD	GSR	471	P00390
RDGILVVGMDCEMHV	DMXL2	1256	Q8TDJ6
LHRMFEVVGGQLTEC	DEDD2	26	Q8WXF8
VHCQLVEEEGRIRAM	RC3H1	141	Q5TC82
GCGQVLLRRDVEAHM	PDZRN3	116	Q9UPQ7
QIMVEGLGEHLERGE	NAP1L2	21	Q9ULW6
DGHDIENECLGMAVL	JAK1	181	P23458
EDECVLMLLEHGADG	POTEB2	181	H3BUK9
EDCIRAGQHGRALME	PARP2	286	Q9UGN5
MEEIVEGCTGALHIL	CTNNB1	566	P35222
ELDVLCNGEIMGKDH	PCGF5	191	Q86SE9
DEAVGMLLEGCHAEF	DST	2016	Q03001
EGEREMENIFHCRLS	NLRP1	681	Q9C000
GCIQMVLGQIEDHRR	CUL7	796	Q14999
HCELVGLDIQDEMGR	ERGIC1	81	Q969X5
LHCGDESMLDIGGER	DDX41	566	Q9UJV9
ACYMEELRHIDLVEG	HK1	236	P19367
MEEIVEGCTGALHIL	JUP	556	P14923
RRGICEDESSHGVIM	PEG3	301	Q9GZU2
VHGICEDLMREQAGE	CUBN	226	O60494
HGRILEMDIEEIQNC	CUBN	1891	O60494
FMGRIDELCDERGHV	CYP24A1	186	Q07973
DLLDIANGHMVCEEG	DPY19L4	661	Q7Z388
ISMRGHEDGGIRLEC	BTN2A1	151	Q7KYR7
LAMCGHDGQVRVAEL	DCAF8L1	256	A6NGE4
TGCIDIILGRHFEQM	AHCY	276	P23526
GDVLRLLHGHMDECL	RYR2	231	Q92736
EDLMTHCGIELDEDG	RYR2	2001	Q92736
CHLRAIGDGEDEMLF	IRS4	381	O14654
GDLHCEIRDQETLLM	MSH5	491	O43196
MAIEGGERTCGVHEL	SYT14	1	Q8NB59
VLCGMGELHIEIIHD	GFM2	531	Q969S9
LIQEEMEVCGEAAGR	PTAR1	176	Q7Z6K3
LLEALHRFGMTEEGC	PUS7L	501	Q9H0K6
EDECVLMLLEHGADG	POTEB	181	A0A0A6YYL3
RLMDHLKAGIEDVCG	SLC9A4	496	Q6AI14
GGLTEQELMEQLEHC	SHKBP1	591	Q8TBC3
ERHEVQLDMEPQGCL	PKN1	456	Q16512
EVMGDGCLNDEHLEE	RANBP6	786	O60518
EACMDGHVEVARLLL	ANKHD1	411	Q8IWZ3
LRMENEHVCGGALID	PRSS45P	11	Q7RTY3
RLEDGCVHPLEEAML	SOX13	391	Q9UN79
KECMEIILRFGEEHG	TRPA1	211	O75762
IEGDKLHLEMFCEGQ	RBP7	111	Q96R05
NDMGETLLHRACIEG	TONSL	526	Q96HA7
QHLSGLEMIRDLCDG	RTCA	51	O00442
REVDHRGGCLMLQDT	UNC5CL	106	Q8IV45
RMTHCGVLEFVADEG	UFD1	76	Q92890