Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionaminoacyltransferase activity

CUL4A TGM4 RMND5A RNF145 RNF139 RNF215

4.00e-04532376GO:0016755
GeneOntologyMolecularFunctionubiquitin protein ligase activity

CUL4A RMND5A RNF145 RNF139 RNF215

5.83e-04372375GO:0061630
GeneOntologyMolecularFunctionubiquitin-like protein ligase activity

CUL4A RMND5A RNF145 RNF139 RNF215

7.91e-04398375GO:0061659
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

SCN11A SCN5A

1.06e-0326372GO:0005248
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

CUL4A RMND5A RNF145 RNF139 RNF215

1.70e-03473375GO:0004842
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

CUL4A RMND5A RNF145 RNF139 RNF215

2.41e-03512375GO:0019787
GeneOntologyMolecularFunctionacyltransferase activity

CUL4A TGM4 RMND5A RNF145 RNF139 RNF215

2.79e-03775376GO:0016746
GeneOntologyMolecularFunctiongrowth factor binding

LRP2 LTBP3 SCN5A

2.99e-03156373GO:0019838
GeneOntologyMolecularFunctionsodium channel activity

SCN11A SCN5A

4.18e-0352372GO:0005272
DomainTRC8_N

RNF145 RNF139

3.22e-062342PF13705
DomainTRC8_N_dom

RNF145 RNF139

3.22e-062342IPR025754
DomainNUT

NUTM2F NUTM2G

3.21e-055342IPR024310
DomainNUT_N

NUTM2F NUTM2G

3.21e-055342IPR024309
DomainNUT

NUTM2F NUTM2G

3.21e-055342PF12881
Domainzf-RING_2

RNF145 RNF139 RNF215

1.15e-0452343PF13639
DomainNa_channel_asu

SCN11A SCN5A

1.43e-0410342IPR001696
DomainNa_trans_assoc

SCN11A SCN5A

1.43e-0410342IPR010526
DomainNa_trans_assoc

SCN11A SCN5A

1.43e-0410342PF06512
DomainZnf_RING-CH

RNF145 RNF139

4.30e-0417342IPR011016
DomainRINGv

RNF145 RNF139

4.30e-0417342SM00744
DomaincEGF

LRP2 LTBP3

1.02e-0326342IPR026823
DomaincEGF

LRP2 LTBP3

1.02e-0326342PF12662
DomainEGF_1

LRP2 LAMB3 PLAU LTBP3

1.14e-03255344PS00022
Domain-

RMND5A RNF145 RNF139 CXXC1 RNF215

1.23e-034493453.30.40.10
DomainEGF-like_CS

LRP2 LAMB3 PLAU LTBP3

1.24e-03261344IPR013032
DomainEGF_2

LRP2 LAMB3 PLAU LTBP3

1.31e-03265344PS01186
DomainZnf_RING/FYVE/PHD

RMND5A RNF145 RNF139 CXXC1 RNF215

1.36e-03459345IPR013083
DomainSAM_2

SAMD12 SAMD10

2.77e-0343342PF07647
DomainZnf_C3HC4_RING-type

RNF145 RNF139 RNF215

3.72e-03172343IPR018957
DomainChannel_four-helix_dom

SCN11A SCN5A

4.82e-0357342IPR027359
Domain-

SCN11A SCN5A

4.82e-03573421.20.120.350
Domain-

MECOM ZFHX3 ZNF610 ZNF83 ZNF789

7.27e-036793453.30.160.60
Domainzf-C3HC4

RNF145 RNF139 RNF215

7.65e-03223343PF00097
Domainzf-C2H2

MECOM ZFHX3 ZNF610 ZNF83 ZNF789

7.90e-03693345PF00096
DomainZnf_C2H2/integrase_DNA-bd

MECOM ZFHX3 ZNF610 ZNF83 ZNF789

7.95e-03694345IPR013087
DomainEGF_3

LRP2 PLAU LTBP3

8.83e-03235343PS50026
DomainEGF

LRP2 PLAU LTBP3

8.83e-03235343SM00181
DomainEGF-like_dom

LRP2 PLAU LTBP3

1.03e-02249343IPR000742
DomainEGF_CA

LRP2 LTBP3

1.07e-0286342PF07645
DomainSAM

SAMD12 SAMD10

1.12e-0288342SM00454
DomainZINC_FINGER_C2H2_2

MECOM ZFHX3 ZNF610 ZNF83 ZNF789

1.24e-02775345PS50157
DomainZINC_FINGER_C2H2_1

MECOM ZFHX3 ZNF610 ZNF83 ZNF789

1.26e-02777345PS00028
DomainSAM_DOMAIN

SAMD12 SAMD10

1.29e-0295342PS50105
DomainSAM

SAMD12 SAMD10

1.34e-0297342IPR001660
DomainEGF_Ca-bd_CS

LRP2 LTBP3

1.34e-0297342IPR018097
DomainZnf_C2H2-like

MECOM ZFHX3 ZNF610 ZNF83 ZNF789

1.39e-02796345IPR015880
DomainEGF_CA

LRP2 LTBP3

1.40e-0299342PS01187
DomainASX_HYDROXYL

LRP2 LTBP3

1.42e-02100342PS00010
DomainZnf_C2H2

MECOM ZFHX3 ZNF610 ZNF83 ZNF789

1.45e-02805345IPR007087
DomainZnF_C2H2

MECOM ZFHX3 ZNF610 ZNF83 ZNF789

1.47e-02808345SM00355
DomainZF_RING_1

RNF145 RNF139 RNF215

1.57e-02291343PS00518
Domain-

SAMD12 SAMD10

1.59e-021063421.10.150.50
DomainEGF-type_Asp/Asn_hydroxyl_site

LRP2 LTBP3

1.59e-02106342IPR000152
DomainZF_RING_2

RNF145 RNF139 RNF215

1.67e-02298343PS50089
DomainRING

RNF145 RNF139 RNF215

1.78e-02305343SM00184
Pubmed

Specialized functions of Nav1.5 and Nav1.9 channels in electrogenesis of myenteric neurons in intact mouse ganglia.

SCN11A SCN5A

1.10e-06237224719102
Pubmed

Epithelial glycoprotein-330 mediates endocytosis of plasminogen activator-plasminogen activator inhibitor type-1 complexes.

LRP2 PLAU

3.30e-0633728344937
Pubmed

The P-selectin gene polymorphism Val168Met: a novel risk marker for the occurrence of primary ventricular fibrillation during acute myocardial infarction.

ZFHX3 SCN5A

6.60e-06437220586826
Pubmed

Early development of electrical excitability in the mouse enteric nervous system.

SCN11A SCN5A

1.10e-05537222875929
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN11A SCN5A

3.95e-05937216382098
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

CUL4A LRP2 MECOM ZFHX3 ZNF610 POM121C SCN5A

1.52e-04111637731753913
Pubmed

An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo.

SCN11A SCN5A

1.67e-041837231666509
Pubmed

The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development.

MECOM ZFHX3

2.07e-042037235177643
Pubmed

Interspecific backcrosses provide an important new tool for centromere mapping of mouse chromosomes.

MECOM PLAU

3.80e-04273728188294
Pubmed

Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study.

LRP2 MECOM

5.35e-043237225189868
Pubmed

Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3 of Structural, Metabolic, and Contractile Related Genes.

CXXC1 SCN5A

7.56e-043837238196272
Pubmed

A single cyclin A gene and multiple cyclin B1-related sequences are dispersed in the mouse genome.

MECOM PLAU

7.96e-04393721535334
Pubmed

Chromosomal location of the octamer transcription factors, Otf-1, Otf-2, and Otf-3, defines multiple Otf-3-related sequences dispersed in the mouse genome.

MECOM PLAU

7.96e-04393721676977
Pubmed

MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment.

RNF145 RNF139

8.37e-044037230759391
GeneFamilySodium voltage-gated channel alpha subunits

SCN11A SCN5A

7.68e-0592721203
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

MECOM ZFHX3 ZNF610 ZNF83 ZNF789

3.80e-0371827528
GeneFamilySterile alpha motif domain containing

SAMD12 SAMD10

7.60e-0388272760
GeneFamilyRing finger proteins

RNF145 RNF139 RNF215

7.77e-0327527358
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TGM4 MECOM PLAU LTBP3

1.64e-05185374af86e75096c1812ae27a78405355957ee8043d84
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LAMB3 MECOM PLAU ZNF83

1.71e-0518737487b3d0478693d4c54ff06b74e5903036b9c1ee6a
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LAMB3 MECOM PLAU ZNF83

1.71e-0518737442a1267bfc27b4460b8409ada580a87c4385841c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LAMB3 MECOM PLAU ZNF83

1.71e-0518737464afdea159f5e67a1e5cea35ce898aae6e80aea5
ToppCellCOVID-19-lung-Secretory|COVID-19 / Disease (COVID-19 only), tissue and cell type

SAMD12 LAMB3 MECOM RNF145

1.90e-0519237459261098ccb52306f837f632ebaea45b90ad30fe
ToppCellAT2_cells-IPF_03|World / lung cells shred on cell class, cell subclass, sample id

SAMD12 LAMB3 MECOM RNF145

2.10e-051973745e0d222872a25bb9e9069d3dffda2844bb69874a
ToppCellPND07-28-samps-Myeloid-Macrophage-macrophage-C|PND07-28-samps / Age Group, Lineage, Cell class and subclass

SHOC1 PLAU REG4

4.03e-05803733413ac5e1c1e59eab6a83b889b870a8db4efccb9
ToppCellTCGA-Thymus-Primary_Tumor-Thymoma-Type_B2-4|TCGA-Thymus / Sample_Type by Project: Shred V9

ARMH2 CD5L REG4

9.58e-05107373b308c2052536373de82099c9da8eb9ba8b933222
ToppCellDividing_Macrophages-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

PBK ZNF610 ZNF789

2.70e-04152373e39cfc346b35235546b303e7d73e4d9d7120a5fb
ToppCell3'-Distal_airway-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CD300A ELMO1 TEFM

3.14e-04160373709ce00699ca05346287868ea55a1affae0859a8
ToppCellPND07-Endothelial-Endothelial_lymphatic|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN11A PLAU SCN5A

3.20e-04161373133b4fadb499e842c19f573f9cf09ce08c1d4813
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN11A PLAU SCN5A

3.20e-04161373cb177ca10d848d0e25399ab5ebfcde1071fb94c2
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN11A PLAU SCN5A

3.20e-041613739466b8658244116f8d21f2f88fb8c2d184b1bdf2
ToppCell10x5'v1-week_17-19-Hematopoietic-HSC/MPP_and_pro-HSC/MPP|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

MECOM REG4 SCN5A

3.20e-04161373aee74a2e7a8acd2950341963f1c04b59c7862183
ToppCellFetal_29-31_weeks-Epithelial-club_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SAMD12 MECOM RNF145

3.25e-041623735c9bc3c3857a99d8a3caf359a7eb279ce9cc1c81
ToppCellPND07-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN11A PLAU SCN5A

3.25e-0416237396c6e94a10b124a1d25dcd705ec5aaa8609c1089
ToppCell10x5'v1-week_17-19-Hematopoietic-HSC/MPP_and_pro|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

MECOM REG4 SCN5A

3.31e-04163373edca1d1a345109dbdeb7ee5464faefab1993fdb2
ToppCellPND01-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_prolif|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PLAU BTLA CD300A

3.43e-04165373ba68090d79e2243af2bdee0c27a32e65f540f8ac
ToppCell10x5'-lymph-node_spleen-Myeloid_Mac-Intermediate_macrophages|lymph-node_spleen / Manually curated celltypes from each tissue

LAMB3 ZFHX3 PLAU

3.43e-04165373c3fa9225d2f9c9e821d4fbd2315fcc98ce1f1c55
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP2 LAMB3 MECOM

3.49e-04166373575c325db88d6909cdf0d5e664bd9098b89d4401
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

MECOM RNF145 DEFB127

3.49e-04166373c20479fe7a4306320d7f26e78bf956225f00f35a
ToppCellfacs-Liver-Hepatocytes-24m-Myeloid-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PBK CD5L CD300A

3.49e-0416637303a47b8687f54955e84df1edcb230db332c4ca8f
ToppCell356C-Myeloid-Dendritic-cDC1|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

SAMD12 SCN11A BTLA

3.49e-04166373971ee6602a1e751f453f9d823295e63dadce62bf
ToppCellfacs-Aorta-Heart-24m-Myeloid-leukocyte|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PBK BTLA CD300A

3.56e-04167373b85fd7ab21c80470bca804c788ce49a2bce763f8
ToppCellControl|World / group, cell type (main and fine annotations)

LRP2 SAMD12 MECOM

3.62e-04168373a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCellwk_20-22-Mesenchymal-Chondrocyte|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

MECOM ZFHX3 SCN11A

3.81e-04171373d2938639e9a7c349e5a6ec61724222f9d127c89f
ToppCellAT1-AT2_cells-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

SHOC1 LAMB3 ZFHX3

3.88e-041723730be41df5d35d818deb7316ac21c9366eb4b7bfd1
ToppCellCOVID-19-kidney-Distal_Epi_Doublet_(PCT)|kidney / Disease (COVID-19 only), tissue and cell type

LRP2 SAMD12 MECOM

4.15e-0417637336f77d878a53b30465b0dea8333a3865dba75613
ToppCellFetal_29-31_weeks-Epithelial-club_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SAMD12 MECOM RNF145

4.15e-041763733bbac5c2397535631fce8fa98f6ddb4fe0260351
ToppCelldroplet-Tongue-nan-3m-Myeloid|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BTLA CD300A ELMO1

4.22e-04177373b6c0ab701d9db3f19605b4d23f7e40adca3324e1
ToppCelldroplet-Tongue-nan-3m-Myeloid-Langerhans_cell|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BTLA CD300A ELMO1

4.22e-041773738f4b2f21091d981c12000489054198127098f62c
ToppCelldroplet-Tongue-nan-3m-Myeloid-Langerhans_cell|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BTLA CD300A ELMO1

4.22e-0417737334bd46704827c9db7053bbd0c671dd0b661b79b4
ToppCellCOVID-19-Epithelial_cells-AT1|COVID-19 / group, cell type (main and fine annotations)

SAMD12 LAMB3 MECOM

4.36e-04179373a0b33bd69ffdfd5d38d80207fb40058a490aa19e
ToppCell3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SCN11A REG4 SYT13

4.36e-041793738ce5000088b727783a0619baa16a2cd036d21f54
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

SAMD12 MECOM RNF145

4.43e-04180373b509c7d6bdfba672065fb722874bdc68de72ba1c
ToppCellAT1-AT2_cells-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

LAMB3 PLAU SCN5A

4.43e-041803733c7b2033821f9e34e2924bd8655f566edcbcc7d3
ToppCell11.5-Distal-Immune-Immune|Distal / Age, Tissue, Lineage and Cell class

SHOC1 BTLA CD300A

4.50e-04181373193ee02f547a218b2fc13e1174ea4cff4f8a3450
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

SAMD12 MECOM RNF145

4.57e-04182373215c303df42f13597b2c7a95cb157c6bc7aca9a1
ToppCellE12.5-Epithelial-epithelial_progenitor_cell-epithelial_progenitor_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LAMB3 SAMD10 REG4

4.57e-04182373204530444e35d4977a7239ac176f477e9e5c29ab
ToppCellwk_20-22-Mesenchymal-Chondrocyte-intermediate_chondrocyte|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

MECOM ZFHX3 SCN11A

4.65e-041833731464b5c4425e8776c4aeb4d2b560481d4bf13931
ToppCellPCW_05-06-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

LRP2 SAMD12 LAMB3

4.65e-04183373c5b10571599dc26476170b54b53f09c23e6b3117
ToppCellCOVID-19-Epithelial_cells-AT2|COVID-19 / group, cell type (main and fine annotations)

LRP2 SAMD12 MECOM

4.72e-04184373369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCellPND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP2 LAMB3 MECOM

4.72e-0418437349705c8fec565b16216bdf48e83e27521f52d99a
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

SAMD12 MECOM RNF145

4.72e-04184373102105ae1a5ef6d42a43f6d9b00f12ed0690ddb7
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-EECs|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

REG4 SYT13 NUTM2G

4.79e-04185373d42f6722a6771752cd744146a09e2ead9b7252bc
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Children_(3_yrs) / Lineage, Cell type, age group and donor

SAMD12 MECOM RNF145

4.79e-0418537398b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SHOC1 SAMD12 MECOM

4.79e-041853733d73b3e0bceb192257e5cfbe64b7ccb379b6e22d
ToppCellPND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP2 LAMB3 MECOM

4.79e-041853732adb32096aa3473f8d417e5ce9e65264beca9b52
ToppCellCOVID-19-Epithelial_cells-Airway_club|COVID-19 / group, cell type (main and fine annotations)

SAMD12 MECOM RNF145

4.79e-04185373cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SAMD12 MECOM RNF145

4.87e-041863732ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCellControl-Endothelial-Endothelial-Artery|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SAMD12 MECOM ELMO1

4.87e-041863732d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SAMD12 MECOM RNF145

4.87e-04186373acfa68a2afb7d2b51c9b469a1965fe5cc5d5e64e
ToppCellCF|World / Disease state, Lineage and Cell class

LAMB3 PLAU RNF145

4.95e-04187373eec4d4e4a658e3a61c05745167a1a5e3d39bb43e
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MECOM PLAU ZNF83

4.95e-0418737377886f99c229610abd28c4c370d2c7d1536c9782
ToppCell3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MECOM SCN11A ELMO1

4.95e-0418737325efb82afe863a853ecdd781ad89026c993aaa67
ToppCellE12.5-Epithelial-alveolar_epithelial_cell-type_I_pneumocyte|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

LAMB3 MECOM SAMD10

4.95e-04187373baff4edc1bf64e3e03864a434fa47075ff7372fd
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MECOM PLAU ZNF83

4.95e-04187373f124d2c699b717b7c02a1a70493f515b83dc2f4c
ToppCellEpithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|World / Lineage, Cell type, age group and donor

SAMD12 MECOM RNF145

4.95e-0418737381cc8435b2704a9a8287b3f54acaae0f11dd4ac7
ToppCellCOVID-19-Epithelial_cells-Airway_basal|COVID-19 / group, cell type (main and fine annotations)

SAMD12 LAMB3 MECOM

4.95e-041873738407a82e98f56a94ea26562bcb6bbe00a8f41661
ToppCellPND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP2 LAMB3 MECOM

5.02e-041883737499e353ea5853d06558b20cedee3c7910425d7d
ToppCellControl-Epithelial_cells|Control / group, cell type (main and fine annotations)

SAMD12 MECOM RNF145

5.02e-04188373707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCellPND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP2 LAMB3 MECOM

5.02e-04188373562f5984efdbbcb8f53ddcee033ccbf9eb678425
ToppCell5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRP2 LAMB3 RNF145

5.10e-04189373da014519d6eb21bc2dc2ed65eafe638b42a068ed
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

LRP2 SAMD12 LAMB3

5.10e-041893737659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCellCOVID-19-lung-Secretory|lung / Disease (COVID-19 only), tissue and cell type

SAMD12 LAMB3 MECOM

5.10e-0418937384d48e3ed25bebb8bb8074b3a2c5e2e88cff7f25
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MECOM PLAU ZNF83

5.10e-04189373e32172ad09e93f6ac6ea2b92145b2b73003f7970
ToppCellPND10-Epithelial|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP2 LAMB3 MECOM

5.10e-0418937389349e226a5512833a94b1bf68056a6985fe4afd
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP2 LAMB3 MECOM

5.18e-041903738ff8c586237cf15f930416710bcff45205fe6f70
ToppCellIPF-Epithelial-Basal|IPF / Disease state, Lineage and Cell class

SAMD12 LAMB3 MECOM

5.18e-04190373ea19e9ce954f2dfde97388db9695325cd92ab88f
ToppCellPND14-Epithelial|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP2 LAMB3 MECOM

5.18e-04190373f1eeef8f201bf7b96c020c8ab53dd7e05b3060ea
ToppCellPND07-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP2 LAMB3 MECOM

5.18e-0419037333d1b0a38267270e87702ba5794f07233acf4955
ToppCellPCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

LRP2 SAMD12 LAMB3

5.18e-04190373625c08a0e5227efc46daa512fd579c3938ff76c7
ToppCellPND10-Epithelial-Epithelial_Alveolar|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP2 LAMB3 MECOM

5.18e-04190373dc20d323cee2741e39fba597263d6418ae0eadaf
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SHOC1 SAMD12 MECOM

5.18e-04190373b3bccf4dd95e986db3cee324a6737f5fcc22e8e5
ToppCellPND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP2 LAMB3 MECOM

5.18e-04190373ec1bd4929dc82bec2c983a31ece4e3aa82f3a2ab
ToppCellPND07-Epithelial-Epithelial_Alveolar|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP2 LAMB3 MECOM

5.18e-04190373ee39fb88f31d2d65b5d3e7416db68f5df07f6637
ToppCellPND07-Epithelial|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP2 LAMB3 MECOM

5.18e-04190373e3a2c8b637f60c963520dffe99c526809d818cab
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

LRP2 SAMD12 LAMB3

5.26e-0419137360ff989fe99d243a3d52955223680cdd1f1917a4
ToppCellPCW_05-06-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

LRP2 SAMD12 LAMB3

5.26e-0419137305731ece7867659c662f952812805f947032fe10
ToppCellChildren_(3_yrs)-Epithelial|Children_(3_yrs) / Lineage, Cell type, age group and donor

SAMD12 MECOM RNF145

5.26e-04191373e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP2 LAMB3 MECOM

5.26e-041913732f71f1fb6b5872d84860840b22e789a87ab14eec
ToppCellChildren_(3_yrs)-Epithelial-club_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

SAMD12 MECOM RNF145

5.26e-0419137323776c7302cead3881b39127398f3b3e0d27885e
ToppCellCOVID-19-lung-AT2|lung / Disease (COVID-19 only), tissue and cell type

LRP2 SAMD12 MECOM

5.26e-04191373276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCellPND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP2 LAMB3 MECOM

5.26e-041913734ab3056f9af2a6caed39f32288562f480811cd7b
ToppCellPND14-Epithelial-Epithelial_Alveolar|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP2 LAMB3 MECOM

5.26e-041913735f8b3b2d38b37027901db9a1cccdbd1ff70f29de
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MECOM PLAU SYT13

5.34e-041923738769b67d1cad1be65da3938f916e5bf88f88f6b8
ToppCellPND28-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP2 LAMB3 MECOM

5.34e-041923737ccdb977320d09f21e70e7718ead73eeb56d0c48
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MECOM PLAU SYT13

5.34e-041923737af2b5240b1fad2177d8022e5f4fc1fe9e8f03b5
ToppCellPND28-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP2 LAMB3 MECOM

5.34e-04192373f206c015f091234e2c86dfa66926e97b2ea99690
ToppCellPCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

LRP2 SAMD12 LAMB3

5.34e-04192373b99f8236ef4ccdc75c02abea381cae6453205f6f
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MECOM PLAU SYT13

5.34e-0419237332e4a180037e516c5cc798cd9dada9385e0f43ae
ToppCellPND28-Epithelial-Epithelial_Alveolar|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP2 LAMB3 MECOM

5.34e-0419237369963e8dc6d6368243e61da133484eb23225625a
ToppCellPND28-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

LRP2 LAMB3 MECOM

5.34e-04192373bfc68af68fdb99ddfe4add49671e4b4c26e6f962
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SAMD12 LAMB3 MECOM

5.42e-0419337380e058c224749b5fe0ba3e944b48317c2371cb63
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SAMD12 LAMB3 MECOM

5.42e-04193373b991fbbb4618401624f0b3045f0e81a606d3a763
ToppCellEpithelial-club_cell|World / Lineage, Cell type, age group and donor

SAMD12 MECOM RNF145

5.42e-041933732bdd09004fa433550958ec42ba4b06271a4aaf7c
ToppCellPCW_05-06-Epithelial-Epithelial_airway|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

LRP2 SAMD12 LAMB3

5.42e-04193373af6ec2c2ba92aef3e41531c3c7215b3300437bd9
ToppCellwk_15-18-Epithelial-Airway_epithelial_progenitor-epi-airway_progenitor_early|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

LRP2 LAMB3 MECOM

5.42e-04193373de569c6e507856fd3ac2311f246cb597074ed30c
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SAMD12 MECOM ZNF83

5.42e-04193373f42a0f02ed00fe1bb833ff0a0640d9131bca89bd
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SAMD12 LAMB3 MECOM

5.42e-04193373263d185af6ed80e639f864e4966268e0862c61dc
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN11A SCN5A

6.47e-0510362DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN11A SCN5A

6.47e-0510362DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN11A SCN5A

9.48e-0512362DOID:0060170 (implicated_via_orthology)
Diseasesuicidal ideation

ZFHX3 LTBP3

5.76e-0429362EFO_0004320
DiseaseDrug-Induced Stevens Johnson Syndrome

CUL4A ELMO1

5.76e-0429362C1274933
DiseaseToxic Epidermal Necrolysis

CUL4A ELMO1

5.76e-0429362C0014518
DiseaseMycoplasma-Induced Stevens-Johnson Syndrome

CUL4A ELMO1

5.76e-0429362C3658301
DiseaseStevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum

CUL4A ELMO1

5.76e-0429362C3658302
DiseaseStevens-Johnson Syndrome

CUL4A ELMO1

6.16e-0430362C0038325
Diseasepack-years measurement, systolic blood pressure

LRP2 MECOM

7.92e-0434362EFO_0006335, EFO_0006526
Diseaseglaucoma

ARMH2 MECOM LTBP3

8.77e-04154363MONDO_0005041
DiseaseParoxysmal atrial fibrillation

CUL4A ZFHX3 SCN5A

9.11e-04156363C0235480
Diseasefamilial atrial fibrillation

CUL4A ZFHX3 SCN5A

9.11e-04156363C3468561
DiseasePersistent atrial fibrillation

CUL4A ZFHX3 SCN5A

9.11e-04156363C2585653
DiseaseAtrial Fibrillation

CUL4A ZFHX3 SCN5A

9.80e-04160363C0004238

Protein segments in the cluster

PeptideGeneStartEntry
EKAASWNQAPKLHYC

SYT13

151

Q7L8C5
QDKFWYCRLSPNHKV

ELMO1

571

Q92556
KYCANRPHVTWCKLN

BTLA

61

Q7Z6A9
ACWCYLNPVSQKRAK

ARMH2

126

H3BNL8
CNKHAYGRKPIWLSQ

CD5L

191

O43866
CPKAFNWKSNLIRHQ

MECOM

296

Q03112
CKTNYRCIPKWAVCN

LRP2

3686

P98164
LKKCWNNYVQGHCRK

DEFB127

21

Q9H1M4
CWNGYHKKAVLSPRN

POM121C

226

A8CG34
RLPKRQCNRHYCWEK

CXXC1

581

Q9P0U4
FLKKINTCWQDHCRQ

CUL4A

131

Q13619
WGQSKCHKCPQLQYT

LTBP3

311

Q9NS15
KCDQCAPYHWKLASG

LAMB3

461

Q13751
WSSNECNKRQHFLCK

REG4

141

Q9BYZ8
CKPKSVYENFRLWQH

NUTM2F

201

A1L443
CKPKSVYENFRLWQH

NUTM2G

201

Q5VZR2
TPCNHYFHALCLRKW

RNF139

561

Q8WU17
SNKYFSNIHWCNCPK

PLAU

41

P00749
KKCWYHSIFACPILR

RMND5A

326

Q9H871
PSPYQRWICCKKAHE

BMT2

251

Q1RMZ1
YFCNKQWLRVLPCKH

RNF215

331

Q9Y6U7
HKCPPCWNRLAQRYL

SCN5A

681

Q14524
DSCWTKHCKELNIPY

SHOC1

821

Q5VXU9
QDVCKWLKKHCPHNY

SAMD10

121

Q9BYL1
DVCKWLKKHCPNQYQ

SAMD12

81

Q8N8I0
HYVGAARSIKCKPWN

TGM4

166

P49221
WALHNFCCRKKSTTP

TEFM

26

Q96QE5
CPYEKEHRTLNKYWC

CD300A

36

Q9UGN4
WRIHTGQKPYKCSEC

ZNF610

251

Q8N9Z0
YCNQLCQKTHWPDHK

USP19

816

O94966
WAVKKINPICNDHYR

PBK

61

Q96KB5
VEPCVWRCQHYQCTK

ZNFX1

1511

Q9P2E3
WRCQHYQCTKLCSEP

ZNFX1

1516

Q9P2E3
EHFCHKWCRKQNLPQ

SCN11A

851

Q9UI33
LKKWLYVQETCPLCH

RNF145

561

Q96MT1
WNRKLGCKCQYKHIV

XYLT2

461

Q9H1B5
NHWRIHTGEKPYKCN

ZNF83

306

P51522
PYQCVICGKSFKWHT

ZNF789

396

Q5FWF6
NSCKTLKCPKCNWHY

ZFHX3

666

Q15911