Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioninositol 1,4,5-trisphosphate-gated calcium channel activity

ITPR2 ITPR3

5.61e-053872GO:0005220
GeneOntologyMolecularFunctionphenanthrene-9,10-epoxide hydrolase activity

AKR7L AKR7A3

5.61e-053872GO:0019119
GeneOntologyMolecularFunctionphenanthrene-epoxide hydrolase activity

AKR7L AKR7A3

5.61e-053872GO:0019118
GeneOntologyMolecularFunctioncarboxylic acid transmembrane transporter activity

SFXN1 ABCC3 SLC22A6 SLC38A10 SLC5A12 SLC1A6

2.90e-04207876GO:0046943
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

SFXN1 SLC46A2 ABCC3 SLC22A6 SLC38A10 SLC5A12 SLC1A6

2.92e-04293877GO:0008514
GeneOntologyMolecularFunctionorganic acid transmembrane transporter activity

SFXN1 ABCC3 SLC22A6 SLC38A10 SLC5A12 SLC1A6

2.98e-04208876GO:0005342
GeneOntologyMolecularFunctionhistone modifying activity

KMT2C KMT2D HDAC6 KAT6B CREBBP CDY1

4.96e-04229876GO:0140993
GeneOntologyMolecularFunctionhistone H3K4 monomethyltransferase activity

KMT2C KMT2D

5.17e-048872GO:0140945
GeneOntologyMolecularFunctionaryl hydrocarbon receptor binding

ARNT ARNT2

6.62e-049872GO:0017162
GeneOntologyMolecularFunctionhistone H3K4 trimethyltransferase activity

KMT2C KMT2D

8.26e-0410872GO:0140999
GeneOntologyMolecularFunctionepoxide hydrolase activity

AKR7L AKR7A3

1.01e-0311872GO:0004301
GeneOntologyMolecularFunctionN-acyltransferase activity

PLA2G4E KAT6B CREBBP CDY1

1.03e-03102874GO:0016410
GeneOntologyMolecularFunctionhydrolase activity, acting on ether bonds

AKR7L AKR7A3

1.42e-0313872GO:0016801
GeneOntologyMolecularFunctionether hydrolase activity

AKR7L AKR7A3

1.42e-0313872GO:0016803
GeneOntologyMolecularFunctionhistone acetyltransferase activity

KAT6B CREBBP CDY1

1.43e-0351873GO:0004402
GeneOntologyMolecularFunctionmismatched DNA binding

PMS1 MLH3

1.65e-0314872GO:0030983
GeneOntologyMolecularFunctionaldose reductase (NADPH) activity

AKR7L AKR7A3

1.65e-0314872GO:0004032
GeneOntologyMolecularFunctioninositol 1,4,5 trisphosphate binding

ITPR2 ITPR3

1.65e-0314872GO:0070679
GeneOntologyMolecularFunctiontransmembrane transporter activity

SFXN1 SLC46A2 ABCC3 SLC22A6 SLC38A10 SLC22A15 MFSD2B GRID1 SLC5A12 SLC1A6 RHAG ITPR2 ITPR3

1.73e-0311808713GO:0022857
GeneOntologyMolecularFunctionpeptide-lysine-N-acetyltransferase activity

KAT6B CREBBP CDY1

1.78e-0355873GO:0061733
GeneOntologyMolecularFunctionicosanoid transmembrane transporter activity

ABCC3 SLC22A6

1.90e-0315872GO:0071714
GeneOntologyMolecularFunctionhistone H3 acetyltransferase activity

KAT6B CREBBP

1.90e-0315872GO:0010484
GeneOntologyMolecularFunctionacyltransferase activity

KMT2C UBR4 AGPAT2 PLA2G4E KAT6B RNF145 CREBBP MED12 NSMCE1 CDY1

1.97e-037758710GO:0016746
GeneOntologyMolecularFunctiontranscription coactivator activity

KMT2C KMT2D KAT6B TRRAP CREBBP MED12

2.10e-03303876GO:0003713
GeneOntologyMolecularFunctionpolyubiquitin modification-dependent protein binding

HDAC6 TOM1 ZRANB3

2.18e-0359873GO:0031593
GeneOntologyMolecularFunctionpeptide N-acetyltransferase activity

KAT6B CREBBP CDY1

2.29e-0360873GO:0034212
GeneOntologyMolecularFunctionphosphatidylinositol binding

AMER1 TOM1 PARD3B PLA2G4E ITPR2 ITPR3

2.59e-03316876GO:0035091
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

ITPR2 ITPR3

2.74e-0318872GO:0015278
GeneOntologyMolecularFunctiontranscription coregulator activity

KMT2C KMT2D KAT6B TRRAP CREBBP NIPBL MED12 CDY1

3.12e-03562878GO:0003712
GeneOntologyMolecularFunctionhistone H3K4 methyltransferase activity

KMT2C KMT2D

3.39e-0320872GO:0042800
GeneOntologyMolecularFunctionATP-dependent DNA damage sensor activity

PMS1 MLH3

3.39e-0320872GO:0140664
GeneOntologyMolecularFunctionL-amino acid transmembrane transporter activity

SFXN1 SLC38A10 SLC1A6

3.69e-0371873GO:0015179
GeneOntologyMolecularFunctiontransporter activity

SFXN1 SLC46A2 ABCC3 SLC22A6 SLC38A10 SLC22A15 MFSD2B GRID1 SLC5A12 SLC1A6 RHAG ITPR2 ITPR3

3.74e-0312898713GO:0005215
GeneOntologyMolecularFunctionacyltransferase activity, transferring groups other than amino-acyl groups

AGPAT2 PLA2G4E KAT6B CREBBP CDY1

3.86e-03238875GO:0016747
GeneOntologyMolecularFunctionsymporter activity

SLC46A2 MFSD2B SLC5A12 SLC1A6

4.20e-03150874GO:0015293
GeneOntologyMolecularFunctionankyrin binding

SPTBN1 RHAG

4.47e-0323872GO:0030506
GeneOntologyMolecularFunctionphosphatidylinositol-5-phosphate binding

TOM1 PLA2G4E

4.47e-0323872GO:0010314
GeneOntologyMolecularFunctionmagnesium ion binding

STK3 ABL2 POLR1A BRSK2 GEM

4.51e-03247875GO:0000287
GeneOntologyMolecularFunctionN-acetyltransferase activity

KAT6B CREBBP CDY1

4.80e-0378873GO:0008080
GeneOntologyMolecularFunctionDNA damage sensor activity

PMS1 MLH3

4.87e-0324872GO:0140612
HumanPhenoIntestinal malrotation

KMT2D AMER1 RREB1 KAT6B CREBBP NIPBL HYDIN MED12

1.23e-05157378HP:0002566
HumanPhenoGastroesophageal reflux

KMT2C KMT2D AMER1 NEXMIF ARNT2 RREB1 KAT6B CREBBP NIPBL CPSF3 MED12 TRAK1 SYNGAP1

3.75e-055173713HP:0002020
HumanPhenoThick lower lip vermilion

KMT2C KMT2D AMER1 NEXMIF MED12 PUS7 SYNGAP1

4.37e-05136377HP:0000179
HumanPhenoProminent forehead

SCYL2 KMT2D AMER1 NEXMIF ARNT2 TRRAP CREBBP MED12 SYNGAP1

7.43e-05261379HP:0011220
HumanPhenoAnal stenosis

KMT2D AMER1 KAT6B MED12

9.35e-0534374HP:0002025
HumanPhenoAbnormal stomach morphology

PMS1 KMT2C KMT2D MLH3 AMER1 NEXMIF ARNT2 RREB1 KAT6B CREBBP NIPBL CPSF3 MED12 TRAK1 SYNGAP1

1.00e-047423715HP:0002577
HumanPhenoProminent lips

KMT2C KMT2D AMER1 NEXMIF MED12 PUS7 SYNGAP1

1.05e-04156377HP:0000184
HumanPhenoSingle transverse palmar crease

KMT2D POLR1A NEXMIF SPTBN1 KAT6B CREBBP NIPBL MED12

1.18e-04215378HP:0000954
HumanPhenoVesicoureteral reflux

KMT2C KMT2D ARNT2 RREB1 TRRAP CREBBP NIPBL MED12

1.43e-04221378HP:0000076
HumanPhenoNatal tooth

KMT2C KMT2D AMER1 CREBBP

1.46e-0438374HP:0000695
HumanPhenoFunctional abnormality of the bladder

KMT2C KMT2D HOGA1 NEXMIF ARNT2 TOM1 AGXT MACF1 RREB1 TRRAP CREBBP NIPBL MED12

1.50e-045903713HP:0000009
HumanPhenoWide nasal bridge

KMT2D AMER1 POLR1A NEXMIF SPTBN1 RREB1 KAT6B TRRAP CREBBP MED12 PUS7 SYNGAP1

1.52e-045083712HP:0000431
HumanPhenoAbnormality of the bladder

KMT2C KMT2D HOGA1 NEXMIF ARNT2 TOM1 AGXT MACF1 RREB1 TRRAP CREBBP NIPBL MED12

2.53e-046213713HP:0000014
HumanPhenoBroad philtrum

KMT2D NEXMIF SPTBN1 SYNGAP1

2.84e-0445374HP:0000289
HumanPhenoAbnormal ureter physiology

KMT2C KMT2D ARNT2 RREB1 TRRAP CREBBP NIPBL MED12

2.92e-04245378HP:0025634
HumanPhenoSmooth philtrum

KMT2D ZNF148 SPTBN1 TRRAP CREBBP MED12 PUS7

3.04e-04185377HP:0000319
HumanPhenoMalrotation of colon

NIPBL MED12

3.05e-044372HP:0004785
HumanPhenoAbnormal dermatoglyphics

SCYL2 KMT2D POLR1A NEXMIF SPTBN1 KAT6B CREBBP NIPBL MED12

3.06e-04314379HP:0007477
HumanPhenoAbnormal external nose morphology

SCYL2 KMT2D ZNF148 HDAC6 POLR1A NEXMIF SPTBN1 RREB1 KAT6B TRRAP CREBBP NIPBL CPSF3 MED12 PUS7 SYNGAP1

3.07e-049163716HP:0010938
HumanPhenoAdvanced eruption of teeth

KMT2C KMT2D AMER1 CREBBP

3.09e-0446374HP:0006288
HumanPhenoAbnormality of the philtrum

KMT2D ZNF148 HDAC6 NEXMIF SPTBN1 ARNT2 RREB1 KAT6B TRRAP CREBBP NIPBL MED12 PUS7 SYNGAP1

3.18e-047263714HP:0000288
HumanPhenoShort philtrum

HDAC6 NEXMIF SPTBN1 RREB1 TRRAP CREBBP MED12 PUS7

3.64e-04253378HP:0000322
HumanPhenoPatent foramen ovale

KMT2D POLR1A TOM1 TRRAP CREBBP MED12

3.66e-04135376HP:0001655
HumanPhenoAbnormal nasolacrimal system morphology

KMT2D KAT6B TRRAP CREBBP MED12

3.67e-0487375HP:0000614
HumanPhenoAbnormal esophagus physiology

KMT2C KMT2D AMER1 POLR1A PYROXD1 NEXMIF ARNT2 MACF1 RREB1 KAT6B CREBBP NIPBL CPSF3 MED12 TRAK1 SYNGAP1

3.82e-049333716HP:0025270
HumanPhenoTracheomalacia

KMT2C AMER1 POLR1A TRRAP

3.95e-0449374HP:0002779
HumanPhenoAbnormality of the lower urinary tract

KMT2C KMT2D HOGA1 NEXMIF SPTBN1 ARNT2 TOM1 AGXT MACF1 RREB1 KAT6B TRRAP CREBBP NIPBL MED12 SYNGAP1

4.02e-049373716HP:0010936
HumanPhenoAbnormal corpus callosum morphology

SCYL2 KMT2C KMT2D AMER1 ZNF148 POLR1A NEXMIF ARNT2 MACF1 KAT6B TRRAP CREBBP CPSF3 MED12 TRAK1 SYNGAP1

4.02e-049373716HP:0001273
HumanPhenoAbnormal lacrimal duct morphology

KMT2D TRRAP CREBBP MED12

4.27e-0450374HP:0011481
HumanPhenoAbnormally folded helix

KMT2D AMER1 RREB1 CREBBP MED12

4.30e-0490375HP:0008544
HumanPhenoAbnormal cerebral ventricle morphology

PMS1 KMT2C KMT2D AMER1 ZNF148 HDAC6 POLR1A NEXMIF SPTBN1 RREB1 KAT6B TRRAP CREBBP NIPBL HYDIN MED12 PUS7

4.32e-0410463717HP:0002118
HumanPhenoAbnormality of the palmar creases

KMT2D POLR1A NEXMIF SPTBN1 KAT6B CREBBP NIPBL MED12

4.38e-04260378HP:0010490
HumanPhenoAutism

SPTBN1 ARNT2 RREB1 CREBBP NIPBL MED12 TRAK1 SYNGAP1

4.86e-04264378HP:0000717
HumanPhenoAbnormal palmar dermatoglyphics

KMT2D POLR1A NEXMIF SPTBN1 KAT6B CREBBP NIPBL MED12

4.98e-04265378HP:0001018
HumanPhenoAnal atresia

KMT2C KMT2D AMER1 RREB1 KAT6B MED12

4.99e-04143376HP:0002023
HumanPhenoAbnormal scrotum morphology

NEXMIF SPTBN1 KAT6B TRRAP CREBBP MED12

4.99e-04143376HP:0000045
HumanPhenoBulbous nose

SCYL2 KMT2D SPTBN1 RREB1 KAT6B TRRAP MED12

5.04e-04201377HP:0000414
HumanPhenoLow-set ears

SCYL2 KMT2D AMER1 ZNF148 HDAC6 POLR1A MACF1 RREB1 KAT6B TRRAP CREBBP NIPBL MED12 PUS7

5.23e-047613714HP:0000369
HumanPhenoThin upper lip vermilion

KMT2D NEXMIF SPTBN1 KAT6B TRRAP CREBBP NIPBL MED12 SYNGAP1

5.41e-04339379HP:0000219
HumanPhenoThin lips

KMT2D NEXMIF SPTBN1 KAT6B TRRAP CREBBP NIPBL MED12 SYNGAP1

5.41e-04339379HP:0000213
HumanPhenoDownslanted palpebral fissures

KMT2D ZNF148 POLR1A NEXMIF RREB1 KAT6B CREBBP MED12 PUS7 TRAK1 SYNGAP1

5.53e-044973711HP:0000494
HumanPhenoAbnormal esophagus morphology

KMT2C KMT2D AMER1 POLR1A PYROXD1 NEXMIF ARNT2 TOM1 MACF1 RREB1 KAT6B CREBBP NIPBL CPSF3 MED12 TRAK1 SYNGAP1

6.27e-0410783717HP:0002031
HumanPhenoAbnormal pinna morphology

SCYL2 KMT2C KMT2D AMER1 ZNF148 HDAC6 POLR1A NEXMIF SPTBN1 AGPAT2 MACF1 RREB1 KAT6B TRRAP CREBBP NIPBL MED12 PUS7 SYNGAP1

6.35e-0412993719HP:0000377
HumanPhenoCoarctation of aorta

KMT2D AMER1 ZNF148 TRRAP CREBBP MED12

6.44e-04150376HP:0001680
HumanPhenoAbnormal upper lip morphology

KMT2D AMER1 ZNF148 HDAC6 POLR1A NEXMIF SPTBN1 ARNT2 RREB1 KAT6B TRRAP CREBBP NIPBL MED12 PUS7 SYNGAP1

6.79e-049803716HP:0000177
HumanPhenoVentricular septal defect

KMT2D AMER1 POLR1A SPTBN1 MACF1 RREB1 KAT6B TRRAP CREBBP NIPBL MED12

6.90e-045103711HP:0001629
HumanPhenoAbnormal helix morphology

KMT2D AMER1 RREB1 KAT6B CREBBP NIPBL MED12

6.94e-04212377HP:0011039
HumanPhenoThick vermilion border

KMT2C KMT2D AMER1 NEXMIF SPTBN1 MED12 PUS7 SYNGAP1

7.03e-04279378HP:0012471
HumanPhenoShawl scrotum

NEXMIF CREBBP MED12

7.27e-0425373HP:0000049
HumanPhenoHyperoxaluria

HOGA1 AGXT

7.56e-046372HP:0003159
HumanPhenoThin vermilion border

SCYL2 KMT2D NEXMIF SPTBN1 KAT6B TRRAP CREBBP NIPBL MED12 SYNGAP1

7.58e-044333710HP:0000233
HumanPhenoAbnormality of the forehead

SCYL2 KMT2D AMER1 ZNF148 HDAC6 POLR1A NEXMIF SPTBN1 ARNT2 AGPAT2 KAT6B TRRAP CREBBP NIPBL MED12 PUS7 TRAK1 SYNGAP1

7.92e-0412083718HP:0000290
HumanPhenoAbnormal ventricular septum morphology

KMT2D AMER1 POLR1A SPTBN1 MACF1 RREB1 KAT6B TRRAP CREBBP NIPBL MED12

8.27e-045213711HP:0010438
HumanPhenoCompulsive behaviors

SPTBN1 TRRAP CREBBP NIPBL MED12 SYNGAP1

8.48e-04158376HP:0000722
HumanPhenoAbnormal aortic morphology

KMT2D AMER1 ZNF148 POLR1A SPTBN1 RREB1 TRRAP CREBBP MED12

8.90e-04363379HP:0030963
HumanPhenoAbnormality of the outer ear

SCYL2 KMT2C KMT2D AMER1 ZNF148 HDAC6 POLR1A NEXMIF SPTBN1 AGPAT2 MACF1 RREB1 KAT6B TRRAP CREBBP NIPBL MED12 PUS7 SYNGAP1

9.35e-0413373719HP:0000356
HumanPhenoMicrocephaly

SCYL2 KMT2C KMT2D ZNF148 POLR1A NEXMIF SPTBN1 ARNT2 MACF1 RREB1 KAT6B TRRAP CREBBP NIPBL CPSF3 MED12 PUS7 TRAK1 SYNGAP1

9.73e-0413413719HP:0000252
HumanPhenoX-linked dominant inheritance

AMER1 HDAC6 NEXMIF MED12

9.73e-0462374HP:0001423
HumanPhenoRestricted or repetitive behaviors or interests

NEXMIF SPTBN1 MACF1 TRRAP CREBBP NIPBL MED12 PUS7 SYNGAP1

9.82e-04368379HP:0031432
HumanPhenoHypoplastic ilia

AMER1 HDAC6 KAT6B CREBBP

1.03e-0363374HP:0000946
HumanPhenoFailure to thrive

KMT2C KMT2D AMER1 POLR1A NEXMIF SPTBN1 AGPAT2 TOM1 AGXT RREB1 KAT6B CREBBP NIPBL CPSF3 MED12 TRAK1 SYNGAP1

1.08e-0311283717HP:0001508
HumanPhenoDecreased head circumference

SCYL2 KMT2C KMT2D ZNF148 POLR1A NEXMIF SPTBN1 ARNT2 MACF1 RREB1 KAT6B TRRAP CREBBP NIPBL CPSF3 MED12 PUS7 TRAK1 SYNGAP1

1.10e-0313543719HP:0040195
HumanPhenoOptic disc coloboma

KMT2D TRRAP NIPBL

1.13e-0329373HP:0000588
HumanPhenoBrain imaging abnormality

SCYL2 KMT2C POLR1A NEXMIF CREBBP SYNGAP1

1.13e-03167376HP:0410263
HumanPhenoPerseverative thought

NEXMIF SPTBN1 MACF1 TRRAP CREBBP NIPBL MED12 PUS7 SYNGAP1

1.17e-03377379HP:0030223
HumanPhenoAbnormal lip morphology

SCYL2 KMT2C KMT2D AMER1 ZNF148 HDAC6 POLR1A NEXMIF SPTBN1 ARNT2 RREB1 KAT6B TRRAP CREBBP NIPBL MED12 PUS7 SYNGAP1

1.21e-0312493718HP:0000159
HumanPhenoPatent ductus arteriosus

KMT2D AMER1 ZNF148 POLR1A RREB1 KAT6B TRRAP CREBBP MED12

1.28e-03382379HP:0001643
HumanPhenoDisordered formal thought process

NEXMIF SPTBN1 MACF1 TRRAP CREBBP NIPBL MED12 PUS7 SYNGAP1

1.38e-03386379HP:0025769
HumanPhenoSlanting of the palpebral fissure

KMT2D ZNF148 POLR1A NEXMIF SPTBN1 RREB1 KAT6B TRRAP CREBBP MED12 PUS7 TRAK1 SYNGAP1

1.39e-037393713HP:0200006
HumanPhenoMild hearing impairment

POLR1A MED12

1.40e-038372HP:0012712
HumanPhenoLabial hypertrophy

AGPAT2 KAT6B

1.40e-038372HP:0000065
HumanPhenoLong thumb

KAT6B MED12

1.40e-038372HP:0032524
DomainInsP3_rcpt-bd

ITPR2 ITPR3

6.27e-053862IPR000493
DomainDNA_mis_repair

PMS1 MLH3

6.27e-053862SM01340
DomainDNA_mismatch_repair_C

PMS1 MLH3

1.25e-044862IPR013507
DomainDNA_mismatch_repair_fam

PMS1 MLH3

1.25e-044862IPR002099
DomainDNA_mis_repair

PMS1 MLH3

1.25e-044862PF01119
DomainDNA_MISMATCH_REPAIR_1

PMS1 MLH3

1.25e-044862PS00058
DomainDNA_mismatch_repair_CS

PMS1 MLH3

2.08e-045862IPR014762
DomainFYrich_C

KMT2C KMT2D

2.08e-045862IPR003889
DomainFYrich_N

KMT2C KMT2D

2.08e-045862IPR003888
DomainFYRC

KMT2C KMT2D

2.08e-045862SM00542
DomainFYRN

KMT2C KMT2D

2.08e-045862SM00541
DomainFYRN

KMT2C KMT2D

2.08e-045862PF05964
DomainFYRC

KMT2C KMT2D

2.08e-045862PF05965
DomainFYRC

KMT2C KMT2D

2.08e-045862PS51543
DomainFYRN

KMT2C KMT2D

2.08e-045862PS51542
DomainRIH_assoc

ITPR2 ITPR3

3.11e-046862PF08454
DomainRIH_assoc-dom

ITPR2 ITPR3

3.11e-046862IPR013662
DomainRIH_dom

ITPR2 ITPR3

3.11e-046862IPR000699
DomainIns145_P3_rcpt

ITPR2 ITPR3

3.11e-046862IPR014821
DomainRyanodine_recept-rel

ITPR2 ITPR3

3.11e-046862IPR015925
Domain-

ITPR2 ITPR3

3.11e-0468621.25.10.30
DomainRYDR_ITPR

ITPR2 ITPR3

3.11e-046862PF01365
DomainIns145_P3_rec

ITPR2 ITPR3

3.11e-046862PF08709
DomainNuc_translocat

ARNT ARNT2

5.76e-048862IPR001067
DomainMIR

ITPR2 ITPR3

9.21e-0410862PS50919
DomainMIR

ITPR2 ITPR3

9.21e-0410862PF02815
DomainMIR

ITPR2 ITPR3

9.21e-0410862SM00472
DomainMIR_motif

ITPR2 ITPR3

9.21e-0410862IPR016093
DomainARM-type_fold

SCYL2 UBR4 COPG2 TRRAP AGBL1 NIPBL ITPR2

9.61e-04339867IPR016024
DomainARM-like

SCYL2 COPG2 TRRAP AGBL1 NIPBL MED12

1.54e-03270866IPR011989
DomainMFS

SLC46A2 SLC22A6 SLC22A15 MFSD2B

1.56e-03108864PS50850
DomainHMG_box

PMS1 KMT2C KMT2D

1.87e-0353863PF00505
DomainHMG

PMS1 KMT2C KMT2D

1.97e-0354863SM00398
DomainPost-SET_dom

KMT2C KMT2D

2.41e-0316862IPR003616
DomainPostSET

KMT2C KMT2D

2.41e-0316862SM00508
DomainPOST_SET

KMT2C KMT2D

2.41e-0316862PS50868
DomainNADP_OxRdtase_dom

AKR7L AKR7A3

2.72e-0317862IPR023210
DomainAldo_ket_red

AKR7L AKR7A3

2.72e-0317862PF00248
DomainAldo/ket_red/Kv-b

AKR7L AKR7A3

2.72e-0317862IPR001395
DomainHATPase_c

PMS1 MLH3

3.06e-0318862SM00387
DomainHMG_box_dom

PMS1 KMT2C KMT2D

3.35e-0365863IPR009071
DomainHATPase_c

PMS1 MLH3

3.41e-0319862PF02518
DomainMFS_dom

SLC46A2 SLC22A6 SLC22A15 MFSD2B

3.42e-03134864IPR020846
DomainKinase-like_dom

SCYL2 STK3 ABL2 RPS6KB1 BRSK2 MACF1 STK31 TRRAP

3.49e-03542868IPR011009
Domain-

SCYL2 COPG2 TRRAP NIPBL MED12

3.62e-032228651.25.10.10
Domain-

PMS1 MLH3

3.77e-03208623.30.565.10
DomainHEAT_REPEAT

SCYL2 COPG2 NIPBL

4.13e-0370863PS50077
Domain-

PMS1 MLH3

4.16e-03218623.30.230.10
DomainHATPase_C

PMS1 MLH3

4.16e-0321862IPR003594
DomainEPHD

KMT2C KMT2D

4.56e-0322862PS51805
DomainRibosomal_S5_D2-typ_fold_subgr

PMS1 MLH3

4.56e-0322862IPR014721
DomainActinin_actin-bd_CS

SPTBN1 MACF1

4.98e-0323862IPR001589
DomainPAS_fold_3

ARNT ARNT2

4.98e-0323862IPR013655
PathwayREACTOME_NPAS4_REGULATES_EXPRESSION_OF_TARGET_GENES

ARNT ARNT2 CREBBP GEM

4.27e-0622724M46437
PathwayWP_TYPE_2_PAPILLARY_RENAL_CELL_CARCINOMA

ARNT SFPQ ARNT2 CREBBP

2.58e-0534724M39771
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_NPAS4

ARNT ARNT2 CREBBP GEM

2.58e-0534724M46422
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_NPAS4

ARNT ARNT2

2.55e-045722MM16637
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PRKN_TO_MGLUR1_SIGNALING_PATHWAY

ITPR2 ITPR3

2.55e-045722M49000
PathwayREACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA

ARNT ARNT2 NFYA CREBBP MED12

3.38e-04118725M27316
PathwayREACTOME_ARYL_HYDROCARBON_RECEPTOR_SIGNALLING

ARNT ARNT2

3.81e-046722M27793
PathwayKEGG_MEDICUS_REFERENCE_CA2_PLCD_ITPR_SIGNALING_PATHWAY

ITPR2 ITPR3

3.81e-046722M47960
PathwayWP_AFLATOXIN_B1_METABOLISM

AKR7L AKR7A3

3.81e-046722MM15846
PathwayREACTOME_ARYL_HYDROCARBON_RECEPTOR_SIGNALLING

ARNT ARNT2

5.31e-047722MM15528
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

KMT2C ARNT SFPQ KMT2D HNRNPM FOXA1 TRRAP MED12 MYEF2

5.10e-0922088935785414
Pubmed

MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.

KMT2C KMT2D CREBBP

6.25e-08488328398509
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

SFPQ POLR1A SPTBN1 UBR4 MACF1 COPG2 TRRAP NIPBL CPSF3 MED12 MYEF2 ITPR3

9.72e-08653881222586326
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

SFXN1 SFPQ HDAC6 SPTBN1 AGPAT2 HNRNPM MACF1 ARHGAP39 TRRAP NIPBL CPSF3 MED12 MYEF2 SYNGAP1

5.53e-071082881438697112
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

MLH3 ZNF148 HDAC6 RTL9 HNRNPM MACF1 RREB1 FOXA1 KAT6B TRRAP AGBL1 CREBBP MYEF2 NSMCE1

7.98e-071116881431753913
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

SFXN1 SFPQ HDAC6 POLR1A PLEKHG4 SPTBN1 UBR4 HNRNPM MACF1 TRRAP CREBBP NIPBL CPSF3 MED12 MYEF2

1.44e-061353881529467282
Pubmed

Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.

SCYL2 PARP4 HSPA12A SFPQ SPTBN1 HNRNPM MACF1 COPG2 NIPBL CPSF3

2.23e-06582881020467437
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

KMT2C PARP4 ARNT SFPQ KMT2D HNRNPM TMEM209 CREBBP MYEF2

2.46e-0645788932344865
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

KMT2D ZNF148 UBR4 KAT6B TRRAP MED12 MYEF2 ITPR2

2.56e-0634188832971831
Pubmed

Functional proteomics mapping of a human signaling pathway.

SCYL2 ARNT SFPQ KMT2D SPTBN1 UBR4 TOM1 MACF1 CREBBP TRAK1

2.56e-06591881015231748
Pubmed

Interaction network of human early embryonic transcription factors.

KMT2C ARNT KMT2D ZNF148 RREB1 CREBBP NIPBL MED12

3.17e-0635188838297188
Pubmed

The mouse Rhl1 and Rhag genes: sequence, organization, expression, and chromosomal mapping.

AKR7L AKR7A3 RHAG

3.39e-061288310495887
Pubmed

Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes?

SFPQ ZNF148 UBR4 TOM1 HNRNPM HYDIN

4.86e-0617088623314748
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

ABCC3 PARP4 KMT2D UBR4 STK31 CREBBP NIPBL MYEF2 CDY1 ITPR3

5.03e-06638881031182584
Pubmed

Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.

KMT2C KMT2D CREBBP

5.58e-061488312482968
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

SFXN1 HSPA12A SFPQ AKR7L SPTBN1 UBR4 HNRNPM BRSK2 AKR7A3 MACF1 ARHGAP39 MYEF2 SYNGAP1

5.74e-061139881336417873
Pubmed

Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.

SFPQ SPTBN1 UBR4 HNRNPM TRRAP NIPBL MED12

6.13e-0627288731010829
Pubmed

Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.

KMT2C KMT2D

6.33e-06288228483418
Pubmed

Divergent expression patterns for hypoxia-inducible factor-1beta and aryl hydrocarbon receptor nuclear transporter-2 in developing kidney.

ARNT ARNT2

6.33e-06288215466261
Pubmed

Isoform diversity of the inositol trisphosphate receptor in cell types of mouse origin.

ITPR2 ITPR3

6.33e-0628829065779
Pubmed

Unique and overlapping transcriptional roles of arylhydrocarbon receptor nuclear translocator (Arnt) and Arnt2 in xenobiotic and hypoxic responses.

ARNT ARNT2

6.33e-06288217023418
Pubmed

Expression of IP3 receptor isoforms at the nodes of Ranvier in rat sciatic nerve.

ITPR2 ITPR3

6.33e-06288217496801
Pubmed

Regulation of multidrug resistance-associated protein 2 by calcium signaling in mouse liver.

ABCC3 ITPR2

6.33e-06288220578149
Pubmed

In vivo CRISPR-Cas9 inhibition of hepatic LDH as treatment of primary hyperoxaluria.

HOGA1 AGXT

6.33e-06288235402636
Pubmed

The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape.

KMT2C KMT2D

6.33e-06288234156443
Pubmed

Mice lacking inositol 1,4,5-trisphosphate receptors exhibit dry eye.

ITPR2 ITPR3

6.33e-06288224901844
Pubmed

Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization.

ITPR2 ITPR3

6.33e-06288233854148
Pubmed

Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors.

ITPR2 ITPR3

6.33e-06288219528657
Pubmed

KMT2C/D COMPASS complex-associated diseases [KCDCOM-ADs]: an emerging class of congenital regulopathies.

KMT2C KMT2D

6.33e-06288231924266
Pubmed

Determination of relative amounts of inositol trisphosphate receptor mRNA isoforms by ratio polymerase chain reaction.

ITPR2 ITPR3

6.33e-0628828063813
Pubmed

Next generation sequencing identified two novel mutations in NIPBL and a frame shift mutation in CREBBP in three Chinese children.

CREBBP NIPBL

6.33e-06288230770747
Pubmed

Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors.

ITPR2 ITPR3

6.33e-0628828081734
Pubmed

Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma.

KMT2C KMT2D

6.33e-06288227280393
Pubmed

Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.

KMT2C KMT2D

6.33e-06288236869380
Pubmed

IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism.

ITPR2 ITPR3

6.33e-06288216195467
Pubmed

Regulation of RB1CC1/FIP200 stability and autophagy function by CREBBP-mediated acetylation in an intrinsically disordered region.

RB1CC1 CREBBP

6.33e-06288236394358
Pubmed

Extended genetic analysis of exome sequencing for primary hyperoxaluria in pediatric urolithiasis patients with hyperoxaluria.

HOGA1 AGXT

6.33e-06288234995728
Pubmed

Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability.

KMT2C KMT2D

6.33e-06288228967912
Pubmed

Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13).

KAT6B CREBBP

6.33e-06288211157802
Pubmed

Molecular cloning of mouse type 2 and type 3 inositol 1,4,5-trisphosphate receptors and identification of a novel type 2 receptor splice variant.

ITPR2 ITPR3

6.33e-06288215632133
Pubmed

Inositol (1,4,5)-trisphosphate receptor links to filamentous actin are important for generating local Ca2+ signals in pancreatic acinar cells.

ITPR2 ITPR3

6.33e-06288215713744
Pubmed

Crucial roles of mixed-lineage leukemia 3 and 4 as epigenetic switches of the hepatic circadian clock controlling bile acid homeostasis in mice.

KMT2C KMT2D

6.33e-06288225346535
Pubmed

A ketogenic diet rescues hippocampal memory defects in a mouse model of Kabuki syndrome.

KMT2D CREBBP

6.33e-06288227999180
Pubmed

PARP4 interacts with hnRNPM to regulate splicing during lung cancer progression.

PARP4 HNRNPM

6.33e-06288239034402
Pubmed

Association of KMT2C/D loss-of-function variants with response to immune checkpoint blockades in colorectal cancer.

KMT2C KMT2D

6.33e-06288236601880
Pubmed

Hdac6 regulates Tip60-p400 function in stem cells.

SFPQ HDAC6 SPTBN1 TRRAP

6.84e-064888424302573
Pubmed

ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes.

SFPQ HNRNPM TRRAP MED12 MYEF2

8.02e-0610788520508642
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

ARNT KMT2D ZNF148 HDAC6 PLEKHG4 UBR4 NFYA FOXA1 TRRAP CREBBP MYEF2

1.09e-05857881125609649
Pubmed

New nomenclature for chromatin-modifying enzymes.

KMT2C KMT2D KAT6B CREBBP

1.36e-055788418022353
Pubmed

Rescue of calcineurin Aα(-/-) mice reveals a novel role for the α isoform in the salivary gland.

ITPR2 ITPR3

1.90e-05388221435446
Pubmed

Expression of Arnt and Arnt2 mRNA in developing murine tissues.

ARNT ARNT2

1.90e-05388212502753
Pubmed

Evidence that type I, II, and III inositol 1,4,5-trisphosphate receptors can occur as integral plasma membrane proteins.

ITPR2 ITPR3

1.90e-05388210874040
Pubmed

Expression of inositol 1,4,5-trisphosphate receptors in mouse oocytes and early embryos: the type I isoform is upregulated in oocytes and downregulated after fertilization.

ITPR2 ITPR3

1.90e-0538829808793
Pubmed

Leveraging the Mendelian disorders of the epigenetic machinery to systematically map functional epigenetic variation.

KMT2D CREBBP

1.90e-05388234463256
Pubmed

Mediator modulates Gli3-dependent Sonic hedgehog signaling.

CREBBP MED12

1.90e-05388217000779
Pubmed

[Purification of recombinant AKR7A5 protein and measurement of substrate specificity of AKR7A5 towards naphthoquinone and its derivatives].

AKR7L AKR7A3

1.90e-05388222863590
Pubmed

Abnormal distribution of inositol 1,4,5-trisphosphate receptors in human muscle can be related to altered calcium signals and gene expression in Duchenne dystrophy-derived cells.

ITPR2 ITPR3

1.90e-05388220395455
Pubmed

Inositol 1,4,5-trisphosphate receptors are autoantibody target antigens in patients with Sjögren's syndrome and other systemic rheumatic diseases.

ITPR2 ITPR3

1.90e-05388217437169
Pubmed

Type 2 and type 3 inositol 1,4,5-trisphosphate (IP3) receptors promote the differentiation of granule cell precursors in the postnatal cerebellum.

ITPR2 ITPR3

1.90e-05388218194433
Pubmed

Coordinated regulation of Rel expression by MAP3K4, CBP, and HDAC6 controls phenotypic switching.

HDAC6 CREBBP

1.90e-05388232859943
Pubmed

Decreased olfactory mucus secretion and nasal abnormality in mice lacking type 2 and type 3 IP3 receptors.

ITPR2 ITPR3

1.90e-05388218547250
Pubmed

hnRNP M interacts with PSF and p54(nrb) and co-localizes within defined nuclear structures.

SFPQ HNRNPM

1.90e-05388219874820
Pubmed

Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins.

AKR7L AKR7A3

1.90e-05388212071861
Pubmed

Inositol 1,4,5-trisphosphate receptor gene variants are related to the risk of breast cancer in a Chinese population.

ITPR2 ITPR3

1.90e-05388236350267
Pubmed

Mouse aldo-keto reductase AKR7A5 protects V79 cells against 4-hydroxynonenal-induced apoptosis.

AKR7L AKR7A3

1.90e-05388216919859
Pubmed

IP3 receptors regulate vascular smooth muscle contractility and hypertension.

ITPR2 ITPR3

1.90e-05388227777977
Pubmed

The versatility and universality of calcium signalling.

ITPR2 ITPR3

1.90e-05388211413485
Pubmed

Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family.

ARNT ARNT2

1.90e-05388236343253
Pubmed

Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.

ITPR2 ITPR3

1.90e-05388226009177
Pubmed

Differential inositol 1,4,5-trisphosphate receptor signaling in a neuronal cell line.

ITPR2 ITPR3

1.90e-05388217581770
Pubmed

cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt).

ARNT ARNT2

1.90e-0538828657146
Pubmed

Predominant role of type 1 IP3 receptor in aortic vascular muscle contraction.

ITPR2 ITPR3

1.90e-05388218241669
Pubmed

Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.

KMT2C KMT2D

1.90e-05388223932714
Pubmed

Characterisation of a novel mouse liver aldo-keto reductase AKR7A5.

AKR7L AKR7A3

1.90e-05388212123834
Pubmed

Receptor-activated single channels in intact human platelets.

ITPR2 ITPR3

1.90e-0538821693919
Pubmed

Granulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization.

ITPR2 ITPR3

1.90e-05388219068129
Pubmed

Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.

ITPR2 ITPR3

1.90e-05388223955339
Pubmed

Type 3 Inositol 1,4,5-Trisphosphate Receptor is a Crucial Regulator of Calcium Dynamics Mediated by Endoplasmic Reticulum in HEK Cells.

ITPR2 ITPR3

1.90e-05388231979185
Pubmed

Tsg101 regulates PI(4,5)P2/Ca(2+) signaling for HIV-1 Gag assembly.

ITPR2 ITPR3

1.90e-05388224904548
Pubmed

Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors.

ITPR2 ITPR3

1.90e-05388217327232
Pubmed

Aldo-keto reductase 7A5 (AKR7A5) attenuates oxidative stress and reactive aldehyde toxicity in V79-4 cells.

AKR7L AKR7A3

1.90e-05388224590062
Pubmed

Analysis of Ah receptor-ARNT and Ah receptor-ARNT2 complexes in vitro and in cell culture.

ARNT ARNT2

1.90e-05388218096572
Pubmed

Mutations of PTCH1, MLL2, and MLL3 are not frequent events in hepatoblastoma.

KMT2C KMT2D

1.90e-05388222183980
Pubmed

AKR7A5 knockout promote acute liver injury by inducing inflammatory response, oxidative stress and apoptosis in mice.

AKR7L AKR7A3

1.90e-05388239365156
Pubmed

Aberrant activation of CYR61 enhancers in colorectal cancer development.

FOXA1 CREBBP

1.90e-05388231118064
Pubmed

Nuclear inositol 1,4,5-trisphosphate receptors regulate local Ca2+ transients and modulate cAMP response element binding protein phosphorylation.

ITPR2 ITPR3

1.90e-05388216014380
Pubmed

KMT2D acetylation by CREBBP reveals a cooperative functional interaction at enhancers in normal and malignant germinal center B cells.

KMT2D CREBBP

1.90e-05388236893259
Pubmed

Knockdown of the type 2 and 3 inositol 1,4,5-trisphosphate receptors suppresses muscarinic antinociception in mice.

ITPR2 ITPR3

1.90e-05388217890015
Pubmed

Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes.

ITPR2 ITPR3

1.90e-05388223983250
Pubmed

Differential distribution of inositol trisphosphate receptor isoforms in mouse oocytes.

ITPR2 ITPR3

1.90e-0538829858485
Pubmed

Activation of the inositol (1,4,5)-triphosphate calcium gate receptor is required for HIV-1 Gag release.

ITPR2 ITPR3

1.90e-05388220427533
Pubmed

HOXC6 Is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment.

KMT2C KMT2D

1.90e-05388221683083
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

PMS1 HSPA12A THEM4 PDPR ZNF148 SPTBN1 UBR4 HNRNPM TMEM209 MACF1 RB1CC1 PUS7 ITPR2 ITPR3

2.13e-051487881433957083
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

KMT2C ARNT SFPQ KMT2D ZNF148 AGPAT2 HNRNPM TMEM209 RREB1 TRRAP NIPBL CPSF3 ITPR3

2.22e-051294881330804502
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

ABCC3 KMT2C SLC38A10 KMT2D UBR4 AGPAT2 GRID1 TRRAP MED12 TRAK1 ITPR2 ITPR3

2.22e-051105881235748872
Pubmed

Tagging genes with cassette-exchange sites.

KMT2C SFPQ ZNF148 UBR4 MACF1 KAT6B CREBBP

2.35e-0533588715741177
Pubmed

Identification of the hypoxia-inducible factor 2α nuclear interactome in melanoma cells reveals master proteins involved in melanoma development.

ARNT ARNT2 CREBBP MED12

2.45e-056688423275444
Pubmed

Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.

KMT2C KMT2D ZNF148 RTL9 PARD3B RB1CC1 TRRAP HYDIN

2.58e-0546988827634302
Pubmed

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

HSPA12A ABL2 SPTBN1 BRSK2 MACF1 ARHGAP39 SYNGAP1

2.94e-0534788717114649
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

SFPQ RPS6KB1 SPTBN1 UBR4 HNRNPM MACF1 ARHGAP39 FRMPD3 NIPBL MYEF2 SYNGAP1

3.18e-05963881128671696
InteractionTEAD1 interactions

KMT2C ARNT KMT2D ZNF148 ARNT2 RREB1 TRRAP CREBBP NIPBL

5.61e-08176859int:TEAD1
InteractionAR interactions

KMT2C ARNT SFPQ KMT2D MLH3 ABL2 ZNF148 TOM1 SH2D3C HNRNPM RREB1 FOXA1 TRRAP CREBBP NIPBL MED12 MYEF2

6.88e-079928517int:AR
InteractionTFAP2D interactions

ARNT PLEKHG4 ARNT2 ADAM12 TRRAP CREBBP

2.07e-0689856int:TFAP2D
InteractionNR6A1 interactions

ARNT ARNT2 TRRAP CREBBP

2.94e-0624854int:NR6A1
InteractionERG interactions

KMT2C SFPQ KMT2D ZNF148 UBR4 HNRNPM CREBBP NIPBL

4.59e-06223858int:ERG
InteractionCRX interactions

KMT2C ARNT KMT2D ZNF148 RREB1 CREBBP NIPBL MED12

1.19e-05254858int:CRX
InteractionHNF4A interactions

KMT2C ARNT KMT2D ZNF148 RREB1 TRRAP CREBBP NIPBL

2.11e-05275858int:HNF4A
InteractionFEV interactions

KMT2C ARNT KMT2D ZNF148 RREB1 CREBBP NIPBL

2.41e-05203857int:FEV
InteractionGSC interactions

KMT2C ARNT KMT2D RREB1 CREBBP

3.34e-0587855int:GSC
InteractionAKR7A3 interactions

AKR7L HOGA1 AKR7A3

4.72e-0517853int:AKR7A3
InteractionNFIX interactions

KMT2C KMT2D ZNF148 RREB1 FOXA1 TRRAP NIPBL

4.91e-05227857int:NFIX
InteractionSOX9 interactions

KMT2C KMT2D TRRAP CREBBP MED12

5.63e-0597855int:SOX9
InteractionSIRT7 interactions

SFPQ POLR1A SPTBN1 UBR4 MACF1 COPG2 TRRAP NIPBL CPSF3 MED12 MYEF2 ITPR3

6.52e-057448512int:SIRT7
InteractionNUP35 interactions

KMT2C PARP4 ARNT SFPQ KMT2D HNRNPM TMEM209 CREBBP MYEF2

7.44e-05424859int:NUP35
InteractionEGR2 interactions

KMT2C KMT2D ZNF148 RREB1 CREBBP NIPBL

8.59e-05171856int:EGR2
InteractionLDB2 interactions

ARNT ARNT2 FOXA1 CREBBP

9.16e-0556854int:LDB2
InteractionSHMT2 interactions

SFXN1 MLH3 PDPR HDAC6 POLR1A UBR4 HNRNPM NFYA MACF1 COPG2 ARHGAP39

1.17e-046718511int:SHMT2
InteractionNYAP2 interactions

HDAC6 BRSK2 SYNGAP1

1.21e-0423853int:NYAP2
InteractionTBXT interactions

KMT2C KMT2D ZNF148 CREBBP NIPBL

1.32e-04116855int:TBXT
InteractionRAC1 interactions

SFXN1 HSPA12A ARNT SFPQ ABL2 HDAC6 PLEKHG4 RPS6KB1 SPTBN1 TOM1 TMEM209 MACF1 ARHGAP39 RB1CC1

1.35e-0410638514int:RAC1
InteractionHSPA12A interactions

HSPA12A PLEKHG4 SPTBN1 RB1CC1 ITPR3

1.61e-04121855int:HSPA12A
InteractionPAX7 interactions

KMT2C ARNT KMT2D RREB1 CREBBP

1.80e-04124855int:PAX7
InteractionYAP1 interactions

SFXN1 KMT2C ARNT SFPQ KMT2D ZNF148 SPTBN1 ARNT2 TOM1 HNRNPM FOXA1 TRRAP CREBBP MED12

1.84e-0410958514int:YAP1
InteractionHSPA12B interactions

PMS1 HSPA12A PLEKHG4 SPTBN1

1.84e-0467854int:HSPA12B
InteractionTADA2A interactions

SFPQ ARNT2 HNRNPM TRRAP MED12 MYEF2

1.91e-04198856int:TADA2A
InteractionNANOG interactions

KMT2C ARNT PDPR HNRNPM RB1CC1 TRRAP MED12 MYEF2 ITPR3

1.93e-04481859int:NANOG
InteractionSLX1A interactions

ARNT HDAC6 UBR4

1.97e-0427853int:SLX1A
InteractionNR4A3 interactions

ARNT ARNT2 TRRAP CREBBP

2.07e-0469854int:NR4A3
InteractionCPNE1 interactions

STK3 HDAC6 NEXMIF SPTBN1

2.07e-0469854int:CPNE1
InteractionCDC5L interactions

SCYL2 PMS1 PARP4 HSPA12A SFPQ SPTBN1 HNRNPM MACF1 COPG2 NIPBL CPSF3 TRAK1

2.40e-048558512int:CDC5L
InteractionSLC1A6 interactions

TRRAP SLC1A6

2.61e-046852int:SLC1A6
InteractionNPAS4 interactions

ARNT ARNT2

2.61e-046852int:NPAS4
InteractionSOX2 interactions

SCYL2 KMT2C PARP4 ARNT KMT2D ZNF148 SPTBN1 UBR4 TOM1 HNRNPM SERPINB2 MACF1 KAT6B NIPBL MYEF2 ITPR2

2.63e-0414228516int:SOX2
InteractionHERC2 interactions

PMS1 ARNT KMT2D SPTBN1 UBR4 MACF1 COPG2 RB1CC1 ITPR2

2.68e-04503859int:HERC2
Cytoband1p36.13

AKR7L UBR4 AKR7A3

1.75e-04568831p36.13
GeneFamilyInositol 1,4,5-triphosphate receptors|Protein phosphatase 1 regulatory subunits

ITPR2 ITPR3

3.69e-053642297
GeneFamilyMutL homologs

PMS1 MLH3

7.37e-0546421027
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

SFPQ HDAC6 RB1CC1 HYDIN ITPR3

4.50e-04181645694
GeneFamilySolute carriers

SLC46A2 SLC22A6 SLC38A10 SLC22A15 SLC5A12 SLC1A6 RHAG

4.79e-04395647752
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

KAT6B CREBBP

1.62e-0317642486
GeneFamilyAtaxins|Trinucleotide repeat containing

KMT2D MED12

3.51e-0325642775
GeneFamilyPHD finger proteins

KMT2C KMT2D KAT6B

3.99e-039064388
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

KMT2C KMT2D

6.43e-0334642487
CoexpressionAtlasDevelopingGonad_e16.5_ovary_emap-9563_top-relative-expression-ranked_1000

KMT2C SFPQ AMER1 PDPR ABL2 ZNF148 PLEKHG4 NEXMIF SPTBN1 RNF145 STK31 CREBBP RHAG ITPR2

3.06e-067958514gudmap_developingGonad_e16.5_ovary_1000
CoexpressionAtlasDevelopingGonad_e18.5_ovary_emap-12283_top-relative-expression-ranked_500

KMT2C SFPQ PDPR ABL2 ZNF148 NEXMIF SPTBN1 RNF145 STK31

2.46e-05387859gudmap_developingGonad_e18.5_ovary_500
CoexpressionAtlasDevelopingGonad_e18.5_ovary_emap-12283_top-relative-expression-ranked_1000

KMT2C SFPQ PDPR ABL2 ZNF148 NEXMIF SPTBN1 RB1CC1 RNF145 STK31 CREBBP ITPR2

6.08e-057788512gudmap_developingGonad_e18.5_ovary_1000
CoexpressionAtlasDevelopingGonad_e12.5_epididymis_emap-29139_top-relative-expression-ranked_1000

SFPQ AMER1 PDPR ABL2 ZNF148 POLR1A NEXMIF SPTBN1 RREB1 RNF145 STK31 CREBBP

8.51e-058068512gudmap_developingGonad_e12.5_epididymis_1000
CoexpressionAtlasDevelopingGonad_e14.5_ testes_emap-6710_top-relative-expression-ranked_1000

HSPA12A SLC38A10 SFPQ PDPR ABL2 ZNF148 PLEKHG4 NEXMIF NFYA STK31 ADAM12 NIPBL

1.03e-048228512gudmap_developingGonad_e14.5_ testes_1000
CoexpressionAtlasDevelopingGonad_e12.5_epididymis_emap-29139_k-means-cluster#2_top-relative-expression-ranked_1000

PDPR ABL2 NEXMIF STK31

1.34e-0465854gudmap_developingGonad_e12.5_epididymis_k2_1000
CoexpressionAtlasDevelopingGonad_e16.5_ovary_emap-9563_top-relative-expression-ranked_500

SFPQ ABL2 ZNF148 NEXMIF SPTBN1 RNF145 STK31 RHAG

1.60e-04387858gudmap_developingGonad_e16.5_ovary_500
ToppCelldroplet-Fat-Bat-18m-Myeloid-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCYL2 PDPR PLEKHG4 TAGAP ARHGAP39 ZRANB3

1.04e-061688866fddc957a0503455d8c165862b5eb8e5fdb8a510
ToppCelldroplet-Fat-Bat-18m-Myeloid-myeloid_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCYL2 PDPR PLEKHG4 TAGAP ARHGAP39 ZRANB3

1.04e-06168886794035cb63353a7d02fd9939deb5b4d075c9d95a
ToppCelldroplet-Fat-Bat-18m-Myeloid|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCYL2 PDPR PLEKHG4 TAGAP ARHGAP39 ZRANB3

1.04e-061688861e23b634f96e88b976a523ca1f3fc08f6fe9b239
DiseaseKleefstra syndrome 2 (implicated_via_orthology)

KMT2C KMT2D

8.79e-062882DOID:0080598 (implicated_via_orthology)
Diseaseprimary hyperoxaluria (implicated_via_orthology)

HOGA1 AGXT

8.79e-062882DOID:2977 (implicated_via_orthology)
DiseaseNeurodevelopmental Disorders

KMT2C NEXMIF BRSK2 PARD3B SYNGAP1

8.89e-0693885C1535926
DiseasePrimary Hyperoxaluria

HOGA1 AGXT

2.63e-053882C0020501
DiseasePrimary hyperoxaluria

HOGA1 AGXT

2.63e-053882cv:C0020501
DiseaseSezary Syndrome

KMT2C KMT2D CREBBP

7.12e-0527883C0036920
DiseasePhyllodes Tumor

KMT2D MED12

8.74e-055882C0010701
DiseaseMalignant Cystosarcoma Phyllodes

KMT2D MED12

8.74e-055882C0600066
DiseaseColorectal Neoplasms

SFXN1 ABCC3 ARNT MLH3 SLC22A15 GRID1

1.84e-04277886C0009404
DiseaseHyperoxaluria

HOGA1 AGXT

2.43e-048882C0020500
DiseaseColorectal Carcinoma

SFXN1 ABCC3 KMT2C ARNT MLH3 OVGP1 RPS6KB1 SLC22A15 GRID1

2.49e-04702889C0009402
Disease2-hydroxystearate measurement

STK3 HOGA1

3.12e-049882EFO_0021059
Diseasemultiple sclerosis, chronic lymphocytic leukemia

RPS6KB1 RREB1

3.12e-049882EFO_0000095, MONDO_0005301
Diseaseesophagus squamous cell carcinoma (is_implicated_in)

KMT2C KMT2D FOXA1

3.32e-0445883DOID:3748 (is_implicated_in)
DiseaseMalignant neoplasm of breast

KMT2D UBR4 SERPINB2 MACF1 RB1CC1 FOXA1 KAT6B ADAM12 NIPBL CPSF3 MED12

3.49e-0410748811C0006142
Diseaseobesity (implicated_via_orthology)

STK3 HDAC6 MED12 ITPR2 ITPR3

4.70e-04215885DOID:9970 (implicated_via_orthology)
Diseaseautosomal dominant cerebellar ataxia (implicated_via_orthology)

ITPR2 ITPR3

5.69e-0412882DOID:1441 (implicated_via_orthology)
DiseaseDiffuse Large B-Cell Lymphoma

KMT2D RPS6KB1 CREBBP

6.01e-0455883C0079744
Diseasecolon carcinoma (is_marker_for)

KMT2D FOXA1

6.71e-0413882DOID:1520 (is_marker_for)
DiseaseLymphoma, Large-Cell, Follicular

KMT2D CREBBP

9.00e-0415882C0079745
DiseaseLymphoma, Small Cleaved-Cell, Follicular

KMT2D CREBBP

9.00e-0415882C0079765
DiseaseLymphoma, Mixed-Cell, Follicular

KMT2D CREBBP

9.00e-0415882C0079758
DiseaseLymphoma, Follicular, Grade 2

KMT2D CREBBP

9.00e-0415882C1956132
DiseaseLymphoma, Follicular, Grade 3

KMT2D CREBBP

9.00e-0415882C1956131
DiseaseLymphoma, Follicular, Grade 1

KMT2D CREBBP

9.00e-0415882C1956130
DiseaseAbnormal behavior

BRSK2 PUS7

1.03e-0316882C0233514
Diseaseautism spectrum disorder (implicated_via_orthology)

NEXMIF CREBBP ITPR3 SYNGAP1

1.13e-03152884DOID:0060041 (implicated_via_orthology)
DiseaseSchizophrenia

HSPA12A GRID1 RB1CC1 ADAM12 TRRAP SLC1A6 MED12 TRAK1 SYNGAP1

1.28e-03883889C0036341
DiseaseLymphoma, Follicular

KMT2D CREBBP

1.61e-0320882C0024301
DiseaseIntellectual Disability

KMT2C BRSK2 MACF1 TRRAP PUS7 SYNGAP1

2.23e-03447886C3714756
DiseaseLynch syndrome (is_implicated_in)

PMS1 MLH3

2.33e-0324882DOID:3883 (is_implicated_in)
DiseaseProstatic Neoplasms

PMS1 KMT2C KMT2D HDAC6 FOXA1 CREBBP MED12

2.47e-03616887C0033578
DiseaseMalignant neoplasm of prostate

PMS1 KMT2C KMT2D HDAC6 FOXA1 CREBBP MED12

2.47e-03616887C0376358
DiseaseSquamous cell carcinoma of esophagus

KMT2C KMT2D CREBBP

2.91e-0395883C0279626
DiseaseHereditary non-polyposis colorectal cancer syndrome

PMS1 MLH3

2.94e-0327882C1112155

Protein segments in the cluster

PeptideGeneStartEntry
KEGQQSSMRMCMGSR

ARNT

246

P27540
LMSQMSGSVTASMAT

CDY1

206

Q9Y6F8
ATVLGAMEMGRRMDA

AKR7L

11

Q8NHP1
ATVLGAMEMGRRMDA

AKR7A3

11

O95154
MASPGMMQSGLSREL

CPSF3

326

Q9UKF6
SMSSGLPEQDRMAMT

ABL2

786

P42684
VQMNSMGSVPGMAIS

CREBBP

751

Q92793
DMDSMTDSMASGGQR

AMER1

336

Q5JTC6
IMSMCTADQSGGIVM

ADAM12

321

O43184
SVSMGAMLGINGAME

AGBL1

131

Q96MI9
MDMNGMSVPTEFLSR

ARNT2

326

Q9HBZ2
SMFGSALQEVMGMQR

ARHGAP39

886

Q9C0H5
MTLNNVTMRQGTVGM

GEM

1

P55040
EMMTQMVLSRGSIFP

ITPR2

926

Q14571
SIQGVGHMMSTMVLS

ITPR3

916

Q14573
VMLAAMAMAAGGIQA

ABCC3

1026

O15438
ARTLTMQRGMNMSVN

KAT6B

1956

Q8WYB5
EGRVDSAMETSMMSV

RB1CC1

1431

Q8TDY2
AMETLRRSMSMEGNI

PARD3B

566

Q8TEW8
QEQRSLEAMMSAAMG

GPN2

266

Q9H9Y4
MVMSRFPFMGQVVTG

KMT2C

3121

Q8NEZ4
MTVSMAQVGADAAMV

HOGA1

121

Q86XE5
AVRNMSYMEKGTMTG

MATN1

341

P21941
MDRMGSVERMGSGIE

HNRNPM

441

P52272
SDTTNCMEMMTGRLS

BRSK2

646

Q8IWQ3
KGSERETQTMGMMSR

MLH3

881

Q9UHC1
ETQTMGMMSRFNELP

MLH3

886

Q9UHC1
MSVGYANGIRVMSMT

PDPR

656

Q8NCN5
EMGDVSSGMSSSIMQ

NIPBL

2266

Q6KC79
METSGIEQMDVTMSG

RPS6KB1

476

P23443
TAYRMTVEMAGTLMG

MFSD2B

181

A6NFX1
MISTMTPMSAQGVQA

MED12

2026

Q93074
SSQGMLRMSPDAMNA

HSPA12A

436

O43301
VSSGNKMMVQMISDA

PCOLCE2

116

Q9UKZ9
MAAEFIMSATPTMGN

PARP4

936

Q9UKK3
AQNIAGGSMMMSEKT

MACF1

2251

Q9UPN3
MMGSKMASASRVVQV

MRPS36

1

P82909
AGGSVMGMMVTTIVF

OR10H4

151

Q8NGA5
IMATGGGTRSMTSMY

PLA2G4E

376

Q3MJ16
GAMNSMTAAGVTAMG

FOXA1

91

P55317
MTSRRLEESMGAVQM

HYDIN

1

Q4G0P3
SNIVAMFEMMDSSGR

EFCAB10

66

A6NFE3
EASMGRPEVSMMSSS

FRMPD3

1021

Q5JV73
VRNGGTSMMVENMAV

CNTN2

1001

Q02246
VMMTFLSNMLRDDGG

COPG2

396

Q9UBF2
MASLDNKATGRMGMR

SLC1A6

116

P48664
GESSVNSMAMRIVMG

GRID1

621

Q9ULK0
MADSMLMQGSRGLTD

HDAC6

1086

Q9UBN7
AVTRFLVGMMNGGMS

SLC22A15

166

Q8IZD6
TMIRQTGMGMGSTMA

SLC22A6

451

Q4U2R8
SNLVTEMLRVGFMMS

SLC38A10

266

Q9HBR0
MSVLGTAVMNNMESF

PMS1

211

P54277
MQGSTRRMGVMTDVH

NSMCE1

1

Q8WV22
SSTAMTVMADLGERM

AGPAT2

146

O15120
GLQMEAENRMMLSSS

OVGP1

611

Q12889
VAGNVVNSGGMVMMV

NFYA

226

P23511
MVYMGSRGSTEDQMA

SERPINB2

41

P05120
LGMSMAVTIRAVTFM

OR52I1

146

Q8NGK6
MRDTASGAMSTSQMT

RTL9

671

Q8NET4
ATVSGGMSMPLMRAQ

RTL9

686

Q8NET4
AGGMQMNSPTSDVMS

RTL9

741

Q8NET4
MSTAQTTAMVSGGMS

RTL9

936

Q8NET4
MSMPQMTATDSRGMS

RTL9

1056

Q8NET4
RIMAAGGLQMIGSMS

AGXT

36

P21549
MMVQSGAKGSTVNTM

POLR1A

896

O95602
GRMSAQVPMNMTITG

SFXN1

91

Q9H9B4
GSMTVGSMRARMLEA

TAGAP

616

Q8N103
MGELYRGAMTSSMER

MYEF2

401

Q9P2K5
VRMAEMVSMGVGNKA

PLEKHG4

1036

Q58EX7
SNIASGMADVQRFMM

NEXMIF

1321

Q5QGS0
MEMTEMTGVSLKRGA

PUS7

1

Q96PZ0
SMGIGMMFSTPTDNT

SCYL2

751

Q6P3W7
TMGSSVMGTQMNVIG

SCYL2

876

Q6P3W7
MRDMGEMVTQGQTDA

SPTBN1

1121

Q01082
RNRSFPTMVGSSMQM

TRAK1

916

Q9UPV9
ATMSGSMMGSDMRTE

SFPQ

651

P23246
SMMGSDMRTERFGQG

SFPQ

656

P23246
QRASVNMMVGDLSLM

STK31

881

Q9BXU1
TMRATSTMSEGAQTM

STK3

336

Q13188
SFMARGLNSSMDMAR

SYNGAP1

771

Q96PV0
MQNGRMMGAVLIGET

PYROXD1

451

Q8WU10
GSDLSSINTMMSAVM

RREB1

11

Q92766
SINTMMSAVMSVGKV

RREB1

16

Q92766
DATVGMCAMMAGGIV

THEM4

161

Q5T1C6
MVSGNVRVMSEMLTE

TOM1

226

O60784
IVAVAMGASNTSMAM

RHAG

346

Q02094
NVSMAGMIYTEMTGK

TMEM209

36

Q96SK2
DRSMASLGRNMMESS

ZNF852

41

Q6ZMS4
RDTTMIMIGMVSFGS

SLC46A2

346

Q9BY10
RGTMGNMFSFAAVMG

SH2D3C

676

Q8N5H7
GIDEMQSSRTMVVMG

ZNF148

16

Q9UQR1
MCTSMAVAASVMGGV

SLC5A12

391

Q1EHB4
TMVMTGMRIQIGTQA

UBR4

2346

Q5T4S7
MNDPAMNRGMTEGVT

RNF145

306

Q96MT1
MMDLTGEVSNGAVAM

TRRAP

1191

Q9Y4A5
MRTPNSGAMETVMGL

ZRANB3

296

Q5FWF4
SGAMETVMGLITRMF

ZRANB3

301

Q5FWF4
PGQSMMGSRDTRMGT

KMT2D

3156

O14686