Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionserine C-palmitoyltransferase activity

SPTLC3 SPTLC2

4.73e-055442GO:0004758
GeneOntologyMolecularFunctionC-palmitoyltransferase activity

SPTLC3 SPTLC2

4.73e-055442GO:0016454
GeneOntologyMolecularFunctionC-acyltransferase activity

SPTLC3 SPTLC2

9.70e-0421442GO:0016408
GeneOntologyMolecularFunctionactin filament binding

PKNOX2 FHOD3 LCP1 PLS3

1.55e-03227444GO:0051015
GeneOntologyCellularComponentleading edge membrane

GABRG2 DPP4 LCP1 NCKAP1 ABCA7

8.60e-05210455GO:0031256
GeneOntologyCellularComponentserine palmitoyltransferase complex

SPTLC3 SPTLC2

1.26e-048452GO:0017059
GeneOntologyCellularComponentpalmitoyltransferase complex

SPTLC3 SPTLC2

2.46e-0411452GO:0002178
GeneOntologyCellularComponentcell projection membrane

GABRG2 DPP4 SLC9A3 LCP1 NCKAP1 ABCA7

3.06e-04431456GO:0031253
GeneOntologyCellularComponentlamellipodium membrane

DPP4 NCKAP1

1.02e-0322452GO:0031258
DomainAA_TRANSFER_CLASS_2

SPTLC3 SPTLC2

8.85e-056462PS00599
DomainAminotrans_II_pyridoxalP_BS

SPTLC3 SPTLC2

8.85e-056462IPR001917
DomainAminotransferase_I/II

SPTLC3 SPTLC2

7.88e-0417462IPR004839
DomainAminotran_1_2

SPTLC3 SPTLC2

7.88e-0417462PF00155
DomainActinin_actin-bd_CS

LCP1 PLS3

1.45e-0323462IPR001589
DomainACTININ_2

LCP1 PLS3

1.45e-0323462PS00020
DomainACTININ_1

LCP1 PLS3

1.45e-0323462PS00019
Domain-

SPTLC3 SPTLC2

3.35e-03354623.90.1150.10
DomainPyrdxlP-dep_Trfase_major_sub2

SPTLC3 SPTLC2

3.54e-0336462IPR015422
Domain-

SPTLC3 SPTLC2

4.15e-03394623.40.640.10
DomainPyrdxlP-dep_Trfase

SPTLC3 SPTLC2

4.58e-0341462IPR015424
DomainPyrdxlP-dep_Trfase_major_sub1

SPTLC3 SPTLC2

4.58e-0341462IPR015421
DomainCH

LCP1 PLS3

1.12e-0265462SM00033
Pubmed

Plastin polymorphisms predict gender- and stage-specific colon cancer recurrence after adjuvant chemotherapy.

LCP1 PLS3

1.71e-06246224170770
Pubmed

Correction of the N-terminal sequences of the human plastin isoforms by using anchored polymerase chain reaction: identification of a potential calcium-binding domain.

LCP1 PLS3

1.71e-0624622378651
Pubmed

Functional differences between L- and T-plastin isoforms.

LCP1 PLS3

1.71e-0624627806577
Pubmed

Mutations in the SPTLC2 subunit of serine palmitoyltransferase cause hereditary sensory and autonomic neuropathy type I.

SPTLC3 SPTLC2

1.71e-06246220920666
Pubmed

Sequential expression and differential localization of I-, L-, and T-fimbrin during differentiation of the mouse intestine and yolk sac.

LCP1 PLS3

5.13e-0634627655078
Pubmed

The Roles of Actin-Binding Domains 1 and 2 in the Calcium-Dependent Regulation of Actin Filament Bundling by Human Plastins.

LCP1 PLS3

5.13e-06346228694070
Pubmed

Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells.

LCP1 PLS3

5.13e-0634628428952
Pubmed

Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?

SPTLC3 SPTLC2

5.13e-06346217331073
Pubmed

Molecular cloning and characterization of plastin, a human leukocyte protein expressed in transformed human fibroblasts.

LCP1 PLS3

5.13e-0634623211125
Pubmed

Association of plasminogen with dipeptidyl peptidase IV and Na+/H+ exchanger isoform NHE3 regulates invasion of human 1-LN prostate tumor cells.

DPP4 SLC9A3

5.13e-06346215911629
Pubmed

Association of mRNA Levels of IL6, MMP-8, GSS in Saliva and Pyelonephritis in Children.

MMP8 GSS

5.13e-06346231881666
Pubmed

Microglia/macrophage-specific protein Iba1 binds to fimbrin and enhances its actin-bundling activity.

LCP1 PLS3

1.03e-05446214756805
Pubmed

Differential localization of villin and fimbrin during development of the mouse visceral endoderm and intestinal epithelium.

LCP1 PLS3

1.03e-0544622686960
Pubmed

Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities.

SPTLC3 SPTLC2

1.71e-05546219416851
Pubmed

Common variants at 12q14 and 12q24 are associated with hippocampal volume.

DPP4 ASTN2

1.71e-05546222504421
Pubmed

Structural insights into the regulation of human serine palmitoyltransferase complexes.

SPTLC3 SPTLC2

2.56e-05646233558761
Pubmed

Evaluation of potential effects of Plastin 3 overexpression and low-dose SMN-antisense oligonucleotides on putative biomarkers in spinal muscular atrophy mice.

DPP4 PLS3

2.56e-05646230188931
Pubmed

Genetic susceptibility to febrile seizures: case-control association studies.

GABRG2 SLC9A3

3.58e-05746219854014
Pubmed

Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways.

LCP1 PLS3

4.77e-05846216115810
Pubmed

A point mutation in the IL-12R beta 2 gene underlies the IL-12 unresponsiveness of Lps-defective C57BL/10ScCr mice.

IL12RB2 CD8B

1.78e-041546211489994
Pubmed

Loss of MYO5B in mice recapitulates Microvillus Inclusion Disease and reveals an apical trafficking pathway distinct to neonatal duodenum.

DPP4 SLC9A3

2.03e-041646227019864
Pubmed

Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.

LCP1 PLS3

2.58e-041846212119179
Pubmed

Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.

AMPD3 MMP8 KCNT2 FAM216B PLS3 TMEM87B

2.76e-0468646629987050
Pubmed

Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs.

ASTN2 FHOD3

3.54e-042146220195266
Pubmed

Proteomic analysis of the cellular responses induced in uninfected immune cells by cell-expressed X4 HIV-1 envelope.

LCP1 PLS3

4.64e-042446217676665
Pubmed

Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development.

SPTLC3 SPTLC2

5.88e-042746223096701
Pubmed

Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil.

SPTLC3 SPTLC2

5.88e-042746225269881
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

PKNOX2 SPTLC3 ASTN2 FAM120A TARS2 ERMARD TM9SF4 KLHL26

6.77e-04148946828611215
Pubmed

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

CYLC2 PKNOX2 KCTD15 ASTN2 FHOD3 TMC2

6.81e-0481446623251661
Pubmed

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.

PIPOX LCP1 NCKAP1 GSS

6.99e-0430446432235678
Pubmed

Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays.

DPP4 TMEM87B

7.77e-043146214684825
Pubmed

Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.

FHOD3 LCP1 SPTLC2

8.36e-0413946325476789
Pubmed

Cdx2 regulates endo-lysosomal function and epithelial cell polarity.

LCP1 PLS3

8.80e-043346220551175
Pubmed

L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.

PHEX IL12RB2 SLC9A3

9.08e-0414346320424473
Pubmed

SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity.

SPTLC3 IL12RB2 SLC9A3 BRICD5 LCP1 KLHL26

1.25e-0391546632393512
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PKNOX2 USP49 RPGRIP1L BRICD5 LAX1

5.74e-07156465a5930b455e5c8586c43c50106ab4d8a1e5e9e3d6
ToppCellTracheal-10x3prime_v2-Immune_Lymphocytic-T-T_CD8-CD8_TRM|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

IL12RB2 DPP4 CD8B LCP1 LAX1

1.72e-06195465c75d04b15d9f95fe2b5650cd4a5a376776610000
ToppCellTracheal-10x5prime-Immune_Lymphocytic-T-T_CD8-MAIT|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

IL12RB2 DPP4 CD8B LCP1 LAX1

1.86e-06198465795e5ae833bbd1a3d16591195301b45eb1c113a4
ToppCellCOVID-19_Severe-CD8+_T_naive|World / disease group, cell group and cell class

GABRG2 CD8B BEX2 CCDC87

1.93e-05154464b568417d88a78d8c46688847f0f5f4989bd36387
ToppCell390C-Lymphocytic-ILC|390C / Donor, Lineage, Cell class and subclass (all cells)

IL12RB2 DPP4 CD8B WDR97

2.46e-05164464b0fc63b72162b5cc4d1e0a271a12f3d3ab29398f
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ASTN2 SLC9A3 KCNT2 SPX

2.46e-05164464382e42701779d12a7948690b3be72d06dd75c8b4
ToppCellBAL-Control-Lymphocyte-T/NK-NK_cell-NK-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IL12RB2 DPP4 BEX2 NCKAP1

2.77e-05169464e9c0e0f4c421c7bdbf1a7e33002f3cf22ea307cb
ToppCellBAL-Control-Lymphocyte-T/NK-NK_cell|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IL12RB2 DPP4 BEX2 NCKAP1

2.77e-05169464d375a1df1ecc938f66bad92e54b8cda26ca9c472
ToppCellBAL-Control-Lymphocyte-T/NK-NK_cell-NK|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IL12RB2 DPP4 BEX2 NCKAP1

2.77e-0516946458f805c0be507bd5fadc9ea3555032daabbc8ab8
ToppCellLPS-IL1RA+antiTNF-Lymphocytic_NKT|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IL12RB2 DPP4 LCP1 LAX1

3.32e-05177464f1efd9c3074d5635700fe7fbebf3dd0b1e0a84f1
ToppCellCTRL-Lymphoid-T_cell_&_NK_cell|CTRL / Disease state, Lineage and Cell class

IL12RB2 DPP4 CD8B LAX1

3.32e-05177464e73d8e78a96b63e27a8a7694c62b3c44ec7ecfe6
ToppCellfacs-Lung-18m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l9|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

IL12RB2 CD8B LCP1 LAX1

3.32e-05177464d6b7d387e7485ff52ce27f51df8b8050f49fd941
ToppCellCF-Lymphoid-T_cell_&_NK_cell|CF / Disease state, Lineage and Cell class

IL12RB2 DPP4 CD8B LAX1

3.70e-05182464a8dfc59a3974e3433f434676b7c2749d0fcfc8b2
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-neurons_B|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GABRG2 FHOD3 TMC2 BEX2

4.03e-0518646415f2e5905486e33f6f7b3b3e9758a0559e8c61ee
ToppCellBAL-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IL12RB2 DPP4 KCNT2 LAX1

4.38e-0519046455df73c8b696967a925b1772631f6900eff0fa30
ToppCellBAL-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IL12RB2 DPP4 KCNT2 LAX1

4.38e-05190464494fbab37305a7f92cddec75b291d42282555f5f
ToppCellPCW_13-14-Immune_Lymphocytic-Immune_Lymphocytic_B-im_lymphoid_progenitor_(7)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

IL12RB2 CD8B LCP1 LAX1

4.75e-0519446469f7bedf6f0be338e4317c22125e727fb82000fc
ToppCellPCW_13-14-Immune_Lymphocytic-Immune_Lymphocytic_B|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

IL12RB2 CD8B LCP1 LAX1

4.84e-051954644570644bcf8bbdfcd70f3cd8840eb94d3df383c8
ToppCellParenchymal-10x5prime-Immune_Lymphocytic-T-T_CD8-MAIT|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

GABRG2 IL12RB2 DPP4 LAX1

5.04e-05197464b8535734a61b718ff17a6a374182f30c1d3bc86f
ToppCellParenchymal-10x3prime_v2-Immune_Lymphocytic-T-T_CD4-CD4|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

IL12RB2 DPP4 LCP1 LAX1

5.24e-051994645fc9bd5740e2e4d657c8c3dd26567db9a6da5af8
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-T-T_CD8-MAIT|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

IL12RB2 DPP4 CD8B LCP1

5.24e-05199464036776a03fdd181e51cc655ed99331eec9c63f39
ToppCellBiopsy_IPF-Immune-T_cells|Biopsy_IPF / Sample group, Lineage and Cell type

IL12RB2 CD8B LCP1 LAX1

5.34e-05200464368c7334d211054f1e914a1be4027aa75e2df66c
ToppCellTracheal-10x3prime_v2-Immune_Lymphocytic-T-T_CD4-CD4_TRM/EMRA|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

DPP4 CD8B LCP1 LAX1

5.34e-05200464283c55076133de5ce195ccad997ffddc56ed32a2
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Pleomorphic_Infiltrating_Lobular_Carcinoma-6|TCGA-Breast / Sample_Type by Project: Shred V9

SLC9A3 MMP8 KLHL26

1.51e-04100463c58e62e0086802f2f20b4def9d49ca8d3f1fba92
ToppCellLPS-antiTNF-Lymphocytic_NKT-iNKT/MAIT-T-cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GABRG2 IL12RB2 LAX1

2.28e-041154633ab39d28717ae585d84c0e0686508faab2fc2e3b
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c10-IFNG|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

BRICD5 LAX1 SPX

2.98e-04126463d19382597ce5c6546731ac1fd33c7dcb7916b2ea
ToppCellControl-Lymphocytic_NKT-T_cells-Erythroid|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DPP4 LCP1 KLHL26

2.98e-04126463f582c3ed43209dca3538e60062b3edd59bf2ad6b
ToppCellLPS-antiTNF-Lymphocytic_NKT-T_cells-iNKT-MAIT|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IL12RB2 DPP4 LAX1

4.06e-04140463a8f3b01d03ee0bf0e752327a98d6b9035930c2b0
ToppCellLPS-antiTNF-Unknown-Endothelial-Monocytes-Macrophages|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ASTN2 TRIM65 LCP1

4.23e-04142463b66f9602dba30d1d4fbcc49ceb112eb5bd916ba1
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lmo1_Myl1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

PIPOX TPBGL GSS

4.41e-041444630322fef818a963be00535d5f141f028d43de5c6a
ToppCellPND14-Immune-Immune_Myeloid-Granulocytic-Neutrophil|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

AMPD3 MMP8 LCP1

4.41e-041444631efa434e577d1f87e02df01667782f414d63bd60
ToppCellPND14-Immune-Immune_Myeloid-Granulocytic-Neutrophil-Neutrophil_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

AMPD3 MMP8 LCP1

4.41e-04144463c0c5f254a960ba5e5f1354599d54e77360e6c2ac
ToppCellE18.5-Immune-Immune_Myeloid-Granulocytic-Neutrophil|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

AMPD3 MMP8 LCP1

4.50e-0414546388e463d5396a8fea2b7b1ecf3c9b144e16b35234
ToppCellE18.5-Immune-Immune_Myeloid-Granulocytic-Neutrophil-Neutrophil_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

AMPD3 MMP8 LCP1

4.50e-04145463911fee7f27694393e348d94470a1a4e890038902
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IL12RB2 LCP1 LAX1

4.77e-041484637cb4865a1e9522e24f9c14799568b67172bd99dc
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lect1_Oxtr|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TPBGL KCNT2 GSS

4.87e-0414946310ffd0051fb027bbebc662ca602c80d89bbf99c6
ToppCellfacs-GAT-Fat-3m-Lymphocytic-NK_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12RB2 LCP1 LAX1

5.06e-041514633d07b79ecbcfad13116f0f2b039bd181a7ffe853
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IL12RB2 LCP1 LAX1

5.06e-041514631525422afadff68a1525ced6d5db45fdea450678
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell-T_gdT_c14-TRDV2|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DPP4 TPBGL PLS3

5.06e-0415146329d91a7d1470121af45fb8bb35175f2acced4551
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_EM-B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

IL12RB2 DPP4 CD8B

5.06e-04151463e1ffd99001b6a5b795f3367882a9355955c0e569
ToppCellmild_COVID-19_(asymptomatic)-NK_CD56bright|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

SPTLC3 IL12RB2 RPGRIP1L

5.06e-041514632470162f4b56bc505db166a6eb0fa54847759df8
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DPP4 TPBGL PLS3

5.06e-041514639ebfbdccc9656fce8990d06622f225009633f07c
ToppCellCOVID-19_Severe-CD8+_T_naive|COVID-19_Severe / disease group, cell group and cell class

GABRG2 CD8B BEX2

5.16e-04152463e6dbf20504c4fb73d1084b587e040855335b8959
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IL12RB2 LCP1 LAX1

5.16e-04152463ed6df77ba04b715e12c2e1591b4a1e894ca49d25
ToppCellInt-URO-Lymphocyte-T_NK-CD8_Naive|Int-URO / Disease, Lineage and Cell Type

DPP4 CD8B BEX2

5.16e-0415246352d6f9cf1f4637c922f582705d625b4cbe3dc0c2
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IL12RB2 LCP1 LAX1

5.16e-041524633951a9f5fe164002311ed2ef7c36ae958451826b
ToppCellPBMC-Control-cDC_2|Control / Compartment, Disease Groups and Clusters

SPTLC3 CD8B FAM216B

5.26e-041534634ee37266b0054f276c7a73ab9220f681b9d74c71
ToppCellmild_COVID-19_(asymptomatic)-NK_CD56bright|World / disease group, cell group and cell class (v2)

SPTLC3 IL12RB2 RPGRIP1L

5.26e-04153463aff5c8ab1fb4ebc324cec02cf562b7484bb10db8
ToppCell367C-Lymphocytic-ILC-ILC-3|367C / Donor, Lineage, Cell class and subclass (all cells)

DPP4 ASTN2 CD8B

5.26e-041534639d64aadbb4bb28469af1d728457b431e21577429
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IL12RB2 LCP1 LAX1

5.26e-04153463e25ddf75d78edfac962c8ec503c9f70f0f7f25bc
ToppCellmild_COVID-19_(asymptomatic)-MAIT|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

IL12RB2 DPP4 LAX1

5.26e-0415346326852f3d8f80e102e24bcb90e24aac26fdc9a32c
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Lymphocytic|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD8B LCP1 TERT

5.36e-04154463ee03b386d28a524084eaf1c0091f7389daa34250
ToppCellfacs-Marrow-KLS-18m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHEX TERT PLS3

5.36e-0415446337765512dfae557b9f6eb30a29463b93682a4404
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Lymphocytic-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD8B LCP1 TERT

5.36e-041544633fa6f77ad2c30ec24b9b904e2732ec5b419dff5b
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lect1_Oxtr|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TPBGL KCNT2 GSS

5.46e-0415546399e749f7075e2c64e9a0bf91009f95b6969197c8
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Lymphocytic|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD8B LCP1 LAX1

5.56e-0415646339aa3adbee9f04cdc0055487d393edfa515e062b
ToppCell10x5'-Liver-Lymphocytic_T_CD4-Tfh|Liver / Manually curated celltypes from each tissue

TIGD4 FHOD3 BRICD5

5.56e-0415646385bc34ff507f9a66c6e3ba7a3ffd5416d0073ccf
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Lymphocytic-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD8B LCP1 LAX1

5.56e-04156463a09e3aefe78d63ad5428ad48c6f83e547eb819f6
ToppCellLPS-antiTNF-Stromal_mesenchymal-Myocytic-Pericyte_2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PKNOX2 KCNT2 FAM216B

5.67e-04157463bfec34182f052cf1c0d847ba53ea335d4d1190de
ToppCellAdult-Immune-mast_cell-D231|Adult / Lineage, Cell type, age group and donor

TMC2 CD8B LAX1

5.67e-041574634c63bb91f8708644e6ce2500072a4eeb8e1079dd
ToppCellsevere_COVID-19-MAIT|severe_COVID-19 / disease group, cell group and cell class (v2)

IL12RB2 DPP4 CD8B

5.67e-04157463175f637e9707836bd63b5c2ccc9d4eb601c05b9e
ToppCellHealthy/Control-CD8+_T_naive|World / Disease group and Cell class

DPP4 CD8B BEX2

5.77e-0415846370680b29428b6bf882b1fae36f924b775961176b
ToppCellfacs-Limb_Muscle-forelimb_and_hindlimb|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PMEL MMP8 LCP1

5.88e-04159463f7803f7b4e0379ae8256ec53110833bedee7db98
ToppCellfacs-Limb_Muscle-forelimb_and_hindlimb-18m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PMEL MMP8 LCP1

5.88e-041594636e2d38e78d2ef7803e8bb154b5c788bf62a41045
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c06-NR4A2|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

DPP4 BEX2 ERMARD

5.88e-04159463b1d5ebd0c186b6d0279dab20d8f3b4a915acdc1f
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Lymphocytic|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD8B LCP1 LAX1

5.99e-041604639e238e7cb31070a5b9da73b4bfddde54b969b0fd
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Lymphocytic-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD8B LCP1 LAX1

5.99e-041604633a5a7984d9ffcb0fbada02b95ffd7aca091acf30
ToppCellfacs-Brain_Non-Myeloid-Hippocampus_-18m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD8B LCP1 LAX1

5.99e-0416046332a105b99fc565c944672f518d6947dcf9ea8832
ToppCell10x5'-Lung-Lymphocytic_T_CD4-Tnaive/CM_CD4|Lung / Manually curated celltypes from each tissue

FHOD3 BEX2 TERT

6.21e-0416246391cc14aec8d580cf97a1929bc1acb00fcbcdb57a
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD8B TARS2 LAX1

6.21e-0416246358fe827198c172eeaa26273b0fad7991a718b0bf
ToppCell3'-Adult-SmallIntestine-Epithelial-mature_enterocytic-Paneth|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

USP49 CD8B ERMARD

6.21e-04162463768a566e76923323c1f197f60bab472a8784490b
ToppCellcellseq-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-ILC|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

IL12RB2 DPP4 LAX1

6.21e-04162463553f91eaba72bcffb733ede45418bbee39c653ab
ToppCell3'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-pDC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PHEX BRICD5 LCP1

6.21e-04162463f12c08d0d4406f9560ecfc3bc2ff38c3bc58f184
ToppCelldroplet-Liver-Npc-21m-Lymphocytic-NK/T|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12RB2 CD8B LAX1

6.32e-041634638569abb769543be55e066119c1dd1c505d5a177e
ToppCelldroplet-Spleen-nan-18m-Myeloid-granulocyte|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PKNOX2 PMEL MMP8

6.32e-04163463bc37c5d9f48b16096d5313657563f3ec84028c8c
ToppCellfacs-Liver-Liver_non-hepato/SCs_st-18m-Lymphocytic-CD8-positive,_alpha-beta_T_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPGRIP1L CD8B LAX1

6.32e-04163463a24db9d266a40f3bffe4f18d277bc269791b4560
ToppCellfacs-BAT-Fat-18m-Lymphocytic-NK_cell|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12RB2 CD8B LAX1

6.43e-04164463ab9c17f86b98e1a4d5db1bd3086edab1320ebda8
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

AMPD3 MMP8 LCP1

6.43e-041644636a113191ea91d103d21c5f056b1950217688ea26
ToppCellfacs-Marrow-T_cells-18m-Lymphocytic-Klrb1a/b/c(-)_NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PKNOX2 MMP8 CD8B

6.55e-04165463eeb58d4db64ad37dc6b441eab22b05c24862e1a9
ToppCelldroplet-Liver-Npc-21m-Lymphocytic-NK_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12RB2 CD8B LAX1

6.55e-041654636708beb0e8094f30cf5cd812e6a67a6db004a580
ToppCell390C-Lymphocytic-NK_cells-NK_cell_B0|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

DPP4 AMPD3 CCDC87

6.55e-04165463ebd668e87e5961a124d1d6fc25d1f03e4af05cd4
ToppCellPND10-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CD8B LCP1 LAX1

6.55e-041654635f606959a060b1ae241217889560c6761ac73bbb
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Lymphocytic-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12RB2 LCP1 LAX1

6.66e-04166463d80c2522cf314d56730d60f160b1247933443378
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Lymphocytic|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12RB2 LCP1 LAX1

6.66e-04166463f2593e2f1043a8cedaa677a73e6b28393991b910
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c02-GPR183|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

TIGD4 CD8B BEX2

6.78e-041674634b6853efefea5178280ba7c31facda0fbd1cc469
ToppCell390C-Lymphocytic-ILC-ILC-2|390C / Donor, Lineage, Cell class and subclass (all cells)

IL12RB2 DPP4 CD8B

6.90e-041684632781dd6b369427a94c5059b44b4c8f023f5f2988
ToppCellfacs-Heart-LA-3m-Lymphocytic|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12RB2 CD8B LCP1

6.90e-0416846316c3313c4186fa327d71215f8eebc31fc12ff1c0
ToppCellfacs-Heart-LA-3m-Lymphocytic-T_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12RB2 CD8B LCP1

6.90e-0416846324d1e0a05cda09ee3b80208d75cb2b601023f3bf
ToppCellmild_COVID-19_(asymptomatic)-pDC|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

PHEX DPP4 PLS3

6.90e-04168463968405ea56f7d001ef83ff9274610923c3b2d55d
ToppCelldroplet-Pancreas-PANCREAS-30m-Hematologic-leukocyte|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MMP8 CD8B LCP1

6.90e-041684635946204d42307391bc2160abe12850815f350aea
ToppCellfacs-Heart-LA-3m-Lymphocytic-T_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12RB2 CD8B LCP1

6.90e-04168463b952af95a68888adedd03b1b60836d18524611ab
ToppCellCOVID-19-kidney-PEC|COVID-19 / Disease (COVID-19 only), tissue and cell type

FHOD3 KCNT2 SPX

6.90e-04168463a086c306be430adf0632ba53e98cd8014d2de330
ToppCellfacs-Heart-RA-24m-Lymphocytic|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GABRG2 CD8B LAX1

7.02e-04169463dcf92121fb00e3b6498e2648363e90ac044ea396
ToppCellCOVID-19_Mild-PLT_2|World / Disease Group and Platelet Clusters

AMPD3 TARS2 KLHL26

7.02e-041694636abfdc8b437f19c03b408bedc245059d28c6ba6a
ToppCell5'-Adult-Appendix-Hematopoietic-T_cells-TRGV2_gdT|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IL12RB2 LCP1 ERMARD

7.02e-041694638caf7996796a2e2716e3855de855c903d6126bf2
ToppCell343B-Lymphocytic-NK_cells-NK_cell_B0|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

DPP4 CD8B SPX

7.02e-0416946389b5452e0d8d058648a1d2659f1611fd6aebc6b6
ToppCelldroplet-Liver-LIVER_HEP-30m-Lymphocytic-NK/T|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL12RB2 CD8B LAX1

7.14e-04170463aff226a84e397ab58204325aa9d8b396a881986e
ToppCell367C-Lymphocytic-NK_cells-NK_cell_B2|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

KCTD15 CD8B NCKAP1

7.14e-04170463c1f7f1bb8865e954bb499963d82bb51923d5d8d6
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Lymphocytic|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD8B LCP1 LAX1

7.14e-04170463c4f00c1acde1d3b521101e469101d10fd257653e
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Lymphocytic-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CD8B LCP1 LAX1

7.14e-04170463d3c1edaf0190d8927578043c372dba7477e75e14
Diseasehereditary sensory and autonomic neuropathy type 1 (implicated_via_orthology)

SPTLC3 SPTLC2

6.51e-063442DOID:0070162 (implicated_via_orthology)
DiseaseHuntington's disease (implicated_via_orthology)

LCP1 PLS3 GSS

1.49e-0532443DOID:12858 (implicated_via_orthology)
DiseaseUterine leiomyoma, estrogen-receptor positive breast cancer

ASTN2 TERT

3.27e-0418442EFO_1000649, HP_0000131
Diseaseresponse to perphenazine

ASTN2 FHOD3

6.90e-0426442GO_0097334
DiseaseUterine leiomyoma, breast carcinoma

ASTN2 TERT

1.05e-0332442EFO_0000305, HP_0000131
Diseasehippocampus molecular layer volume

DPP4 ASTN2

1.25e-0335442EFO_0009397
Diseasehippocampal CA3 volume

DPP4 ASTN2

1.33e-0336442EFO_0009395
Diseasedentate gyrus volume measurement

DPP4 ASTN2

1.55e-0339442EFO_0010083
Diseasehippocampal CA4 volume

DPP4 ASTN2

1.72e-0341442EFO_0009396
Diseasecolonic neoplasm

TIGD4 ASTN2

1.72e-0341442EFO_0004288
Diseasesubiculum volume

DPP4 ASTN2

1.89e-0343442EFO_0009399
Diseaseneutrophil percentage of leukocytes

USP49 AMPD3 TERT ABCA7 TMEM87B

2.07e-03610445EFO_0007990
Diseaseanti-thyroglobulin antibody measurement

SLC9A3 RPGRIP1L

2.16e-0346442EFO_0009896
Diseasehippocampal CA1 volume

DPP4 ASTN2

2.35e-0348442EFO_0009394

Protein segments in the cluster

PeptideGeneStartEntry
VQRLCMRTPIYWARR

BRICD5

181

Q6PL45
IMRIYNSRPQWEALQ

FAM216B

46

Q8N7L0
QLRGDRRQPLWMYRS

CYLC2

66

Q14093
MLYWLQQQRRVRHLV

CCDC87

816

Q9NVE4
YPMVQQWRVRSNLYR

ASTN2

851

O75129
LWKNFMYRRRQPVQL

ABCA7

11

Q8IZY2
NMRWIIQVPRIYDIF

AMPD3

466

Q01432
RYFWRRHPQLQRVEM

MMP8

301

P22894
YWFRLRVPMDQAIRL

RPGRIP1L

731

Q68CZ1
RLRYRPSNSRLWNMV

IL12RB2

256

Q99665
GQYPIWMNQRQRKRL

LLPH

91

Q9BRT6
TLALIWQLMRRYTLN

LCP1

491

P13796
ALVWQLMRRYTLNVL

PLS3

496

P13797
RQRAKNIYDILPWRQ

LAX1

86

Q8IWV1
ISLQWLRRIQNYSVM

DPP4

311

P27487
YMVQWPGARILRRQE

FAM120A

721

Q9NZB2
RVLQIPMWSQRVIYL

KCNT2

346

Q6UVM3
QLWRVMTQQERRPYC

MEIOSIN

576

C9JSJ3
QMVYPRRNLSADQWR

NCKAP1

211

Q9Y2A7
YDPHLNRWLRLQAMQ

KLHL26

386

Q53HC5
SLSNMRIYWLRQRQA

CD8B

46

P10966
FRVRQPILQYRWDIM

BEX2

56

Q9BXY8
YIWDQLMANPRELRI

FHOD3

786

Q2V2M9
PNRMLRIWNDGRVLY

GABRG2

166

P18507
LRSRQRQNYLRMWSS

ERMARD

566

Q5T6L9
RQNYLRMWSSIRLLS

ERMARD

571

Q5T6L9
MPRQYSLQNWEARLL

GSS

271

P48637
NNWFINARRRILQPM

PKNOX2

336

Q96KN3
MALYQRWRCLRLQGL

TARS2

1

Q9BW92
LLERRNWTPQAMLYL

SPX

31

Q9BT56
VVLQTWLLNRYRMVQ

SLC9A3

386

P48764
WLLNRYRMVQLEPID

SLC9A3

391

P48764
RNLYMRIRDNWNRPI

SPTLC3

116

Q9NUV7
SRQLRTKAWNRQLYP

PMEL

36

P40967
LFQVIRLYQRRRWMI

CYP4Z1

26

Q86W10
IPRQIPEQRWYMNRF

TM9SF4

486

Q92544
LYMRIRDNWNRPICS

SPTLC2

126

O15270
YQLQPMVRELERWQQ

KCTD15

141

Q96SI1
MQLWRVRELYSPLAQ

WDR97

406

A6NE52
LMRWYRIAQCLNVPV

TIGD4

91

Q8IY51
QPQMLTALWYRRQRL

USP49

136

Q70CQ1
LVWRMVYSRIPNLSR

PHEX

366

P78562
VIMFLWRPSANNQRY

TMEM87B

446

Q96K49
LYLNRRGIQRWMRNL

TPBGL

326

P0DKB5
EMPLQTLRINVCYWR

PIPOX

216

Q9P0Z9
NQRTIGWLRYRLPMA

TMC2

326

Q8TDI7
PLRRKLWQNYRNLTF

TRIM65

321

Q6PJ69
RLPQRYWQMRPLFLE

TERT

381

O14746