Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	GOLGA6L	GOLGA6L10 GOLGA6L19 GOLGA6L9	4.54e-07	6	54	3	IPR026737
Domain	K_chnl_inward-rec_Kir2.2	KCNJ12 KCNJ18	8.21e-06	2	54	2	IPR003272
Domain	GOLGA2L5	GOLGA6L10 GOLGA6L19 GOLGA6L9	1.81e-05	18	54	3	PF15070
Domain	Golgin_A	GOLGA6L10 GOLGA6L19 GOLGA6L9	1.81e-05	18	54	3	IPR024858
Domain	K_chnl_inward-rec_Kir_N	KCNJ12 KCNJ18	2.46e-05	3	54	2	IPR013673
Domain	IRK_N	KCNJ12 KCNJ18	2.46e-05	3	54	2	PF08466
Domain	CYCLIN	CCNI2 CCNE2 BRF2	1.79e-04	38	54	3	SM00385
Domain	-	CCNI2 CCNE2 BRF2	2.09e-04	40	54	3	1.10.472.10
Domain	Cyclin-like	CCNI2 CCNE2 BRF2	2.60e-04	43	54	3	IPR013763
Domain	PI3/4_kinase_CS	SMG1 PIK3CB	8.41e-04	15	54	2	IPR018936
Domain	K_chnl_inward-rec_Kir_cyto	KCNJ12 KCNJ18	9.59e-04	16	54	2	IPR013518
Domain	-	SMG1 PIK3CB	9.59e-04	16	54	2	1.10.1070.11
Domain	IRK	KCNJ12 KCNJ18	9.59e-04	16	54	2	PF01007
Domain	-	KCNJ12 KCNJ18	9.59e-04	16	54	2	2.60.40.1400
Domain	K_chnl_inward-rec_Kir	KCNJ12 KCNJ18	9.59e-04	16	54	2	IPR016449
Domain	PI3Kc	SMG1 PIK3CB	9.59e-04	16	54	2	SM00146
Domain	PI3/4_kinase_cat_dom	SMG1 PIK3CB	1.22e-03	18	54	2	IPR000403
Domain	PI3_PI4_kinase	SMG1 PIK3CB	1.22e-03	18	54	2	PF00454
Domain	PI3_4_KINASE_3	SMG1 PIK3CB	1.22e-03	18	54	2	PS50290
Domain	PI3_4_KINASE_1	SMG1 PIK3CB	1.22e-03	18	54	2	PS00915
Domain	PI3_4_KINASE_2	SMG1 PIK3CB	1.22e-03	18	54	2	PS00916
Domain	CYCLINS	CCNI2 CCNE2	2.96e-03	28	54	2	PS00292
Domain	Ig_E-set	KCNJ12 KCNJ18 PLXNA2	3.39e-03	104	54	3	IPR014756
Domain	PSI	PLXDC1 PLXNA2	3.85e-03	32	54	2	PF01437
Domain	Plexin_repeat	PLXDC1 PLXNA2	3.85e-03	32	54	2	IPR002165
Domain	Cyclin_N	CCNI2 CCNE2	4.09e-03	33	54	2	IPR006671
Domain	Cyclin_N	CCNI2 CCNE2	4.09e-03	33	54	2	PF00134
Domain	PSI	PLXDC1 PLXNA2	7.83e-03	46	54	2	SM00423
Pubmed	Role of Kir2.2 in hypercapnic ventilatory response during postnatal development of mouse.	KCNJ12 KCNJ18	2.73e-06	2	58	2	15705530
Pubmed	Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein.	SMG1 UPF1	2.73e-06	2	58	2	11331269
Pubmed	Molecular cloning and functional expression of cDNA encoding a second class of inward rectifier potassium channels in the mouse brain.	KCNJ12 KCNJ18	8.19e-06	3	58	2	8083233
Pubmed	The consequences of disrupting cardiac inwardly rectifying K(+) current (I(K1)) as revealed by the targeted deletion of the murine Kir2.1 and Kir2.2 genes.	KCNJ12 KCNJ18	8.19e-06	3	58	2	11410627
Pubmed	Low-affinity spermine block mediating outward currents through Kir2.1 and Kir2.2 inward rectifier potassium channels.	KCNJ12 KCNJ18	8.19e-06	3	58	2	17640933
Pubmed	Proteasome inhibitors and knockdown of SMG1 cause accumulation of Upf1 and Upf2 in human cells.	SMG1 UPF1	8.19e-06	3	58	2	24173962
Pubmed	Targeted disruption of Kir2.1 and Kir2.2 genes reveals the essential role of the inwardly rectifying K(+) current in K(+)-mediated vasodilation.	KCNJ12 KCNJ18	8.19e-06	3	58	2	10904001
Pubmed	Assignment of the murine inward rectifier potassium channel Irk2 (Kir2.2) gene to the central region of mouse chromosome 11.	KCNJ12 KCNJ18	1.64e-05	4	58	2	8921409
Pubmed	The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells.	SMG1 UPF1	1.64e-05	4	58	2	15175154
Pubmed	Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay.	SMG1 UPF1	1.64e-05	4	58	2	11544179
Pubmed	Functional characterization of inward rectifier potassium ion channel in murine fetal ventricular cardiomyocytes.	KCNJ12 KCNJ18	1.64e-05	4	58	2	20798526
Pubmed	A Soluble Epoxide Hydrolase Inhibitor Upregulated KCNJ12 and KCNIP2 by Downregulating MicroRNA-29 in a Mouse Model of Myocardial Infarction.	KCNJ12 KCNJ18	1.64e-05	4	58	2	32990585
Pubmed	Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria.	GJD3 KCNJ12 KCNJ18	1.91e-05	31	58	3	17473172
Pubmed	Dendritic excitability of mouse frontal cortex pyramidal neurons is shaped by the interaction among HCN, Kir2, and Kleak channels.	KCNJ12 KCNJ18	2.72e-05	5	58	2	16177047
Pubmed	The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation.	SMG1 UPF1	2.72e-05	5	58	2	26841701
Pubmed	Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.	SMG1 UPF1	4.08e-05	6	58	2	12554878
Pubmed	Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay.	SMG1 UPF1	4.08e-05	6	58	2	25770585
Pubmed	Genetic mapping refines DFNB3 to 17p11.2, suggests multiple alleles of DFNB3, and supports homology to the mouse model shaker-2.	KCNJ12 KCNJ18	4.08e-05	6	58	2	9529344
Pubmed	Improving GENCODE reference gene annotation using a high-stringency proteogenomics workflow.	PNMA6F PNMA6E	4.08e-05	6	58	2	27250503
Pubmed	The inward rectifier potassium channel family.	KCNJ12 KCNJ18	4.08e-05	6	58	2	7580148
Pubmed	Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends.	SMG1 UPF1	5.71e-05	7	58	2	17916692
Pubmed	Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7.	SMG1 UPF1	5.71e-05	7	58	2	14636577
Pubmed	Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways.	SMG1 UPF1	5.71e-05	7	58	2	18256688
Pubmed	Gamma motor neurons survive and exacerbate alpha motor neuron degeneration in ALS.	KCNJ12 KCNJ18	7.60e-05	8	58	2	27930290
Pubmed	The human RNA surveillance factor UPF1 is required for S phase progression and genome stability.	SMG1 UPF1	9.77e-05	9	58	2	16488880
Pubmed	Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3.	B4GALNT1 BAX	9.77e-05	9	58	2	18308723
Pubmed	Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2.	CCNE2 CDK7	9.77e-05	9	58	2	7799941
Pubmed	Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay.	SMG1 UPF1	1.22e-04	10	58	2	18423202
Pubmed	Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase.	CCNE2 CDK7	1.22e-04	10	58	2	7629134
Pubmed	A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels.	KCNJ12 KCNJ18	1.22e-04	10	58	2	14960569
Pubmed	The mRNA repressor TRIM71 cooperates with Nonsense-Mediated Decay factors to destabilize the mRNA of CDKN1A/p21.	SMG1 UPF1	1.78e-04	12	58	2	31732746
Pubmed	A physical map of the mouse shaker-2 region contains many of the genes commonly deleted in Smith-Magenis syndrome (del17p11.2p11.2).	KCNJ12 KCNJ18	2.11e-04	13	58	2	10049592
Pubmed	Inhibition of crystallin expression and induction of apoptosis by lens-specific E1A expression in transgenic mice.	CCNE2 BAX	2.46e-04	14	58	2	11850820
Pubmed	Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay.	SMG1 UPF1	2.46e-04	14	58	2	16452507
Pubmed	The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex.	SMG1 UPF1	4.11e-04	18	58	2	25220460
Pubmed	Evidence for distinct functions for human DNA repair factors hHR23A and hHR23B.	SZT2 UBA3	4.11e-04	18	58	2	16712842
Pubmed	PITX2 insufficiency leads to atrial electrical and structural remodeling linked to arrhythmogenesis.	KCNJ12 KCNJ18	4.11e-04	18	58	2	21511879
Pubmed	Secreted retrovirus-like GAG-domain-containing protein PEG10 is regulated by UBE3A and is involved in Angelman syndrome pathophysiology.	RBM25 UPF1	4.59e-04	19	58	2	34467244
Pubmed	A functional reference map of the RNF8 interactome in cancer.	RBM25 PBRM1 DSC1 SPTAN1	4.89e-04	218	58	4	35831895
Pubmed	SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay.	SMG1 UPF1	5.09e-04	20	58	2	19417104
Pubmed	Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.	PDE3A PBRM1	5.62e-04	21	58	2	22479202
Pubmed	HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells.	PIK3CB BAX	6.18e-04	22	58	2	11994280
Pubmed	A general approach for investigating enzymatic pathways and substrates for ubiquitin-like modifiers.	CCNE2 UBA3	7.37e-04	24	58	2	16620772
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	NEPRO PBRM1 DSC1 INTS2 MED16 BAX TMED9 NUP160	8.27e-04	1203	58	8	29180619
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	SMG1 PBRM1 MED16 UPF1 NUP160	8.37e-04	440	58	5	34244565
Pubmed	Penetrance of craniofacial anomalies in mouse models of Smith-Magenis syndrome is modified by genomic sequence surrounding Rai1: not all null alleles are alike.	KCNJ12 KCNJ18	9.34e-04	27	58	2	17273973
Pubmed	HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.	PDE3A PIK3CB	9.34e-04	27	58	2	11156964
Pubmed	PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.	PLXDC1 SLITRK3 PLXNA2	1.00e-03	117	58	3	17145500
Pubmed	The protein interaction landscape of the human CMGC kinase group.	RBM25 DSC1 MED16 CCNE2 SPTAN1 CDK7	1.04e-03	695	58	6	23602568
Pubmed	AAA+ proteins RUVBL1 and RUVBL2 coordinate PIKK activity and function in nonsense-mediated mRNA decay.	SMG1 UPF1	1.08e-03	29	58	2	20371770
Pubmed	RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex.	PBRM1 UPF1	1.08e-03	29	58	2	36800290
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	PBRM1 DSC1 INTS2 SPTAN1	1.11e-03	272	58	4	31010829
Pubmed	Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs.	PBRM1 BRF2	1.15e-03	30	58	2	11483580
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	NEPRO DSC1 USP32 UBA3 TMEM104 NUP160 KIF7	1.37e-03	1005	58	7	19615732
Pubmed	Intrinsically Disordered Protein TEX264 Mediates ER-phagy.	RBM25 SPTAN1 UPF1	1.39e-03	131	58	3	31006538
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	PBRM1 INTS2 SZT2 PIK3CB BAX TMED9 UBA3 UPF1	1.55e-03	1327	58	8	32694731
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	OR10H3 MED16 CYP4F12 UPF1 ABCA7 SBNO2	4.59e-04	797	57	6	chr19p13
Cytoband	3p21	PBRM1 ABHD5	7.80e-04	33	57	2	3p21
Cytoband	15q25.2	GOLGA6L10 GOLGA6L9	1.32e-03	43	57	2	15q25.2
Cytoband	19p13.1	OR10H3 CYP4F12	1.65e-03	48	57	2	19p13.1
Cytoband	19p13.3	MED16 ABCA7 SBNO2	3.24e-03	237	57	3	19p13.3
GeneFamily	Potassium voltage-gated channel subfamily J	KCNJ12 KCNJ18	5.34e-04	16	39	2	276
GeneFamily	Cyclins	CCNI2 CCNE2	1.65e-03	28	39	2	473
Drug	Ethamivan [304-84-7]; Up 200; 18uM; PC3; HT_HG-U133A	SLC11A2 PLXDC1 PIK3CB BAX ABCA7 MAN1B1	6.36e-06	197	53	6	7260_UP
Drug	calpeptin	CCNE2 SPTAN1 BAX	6.53e-06	16	53	3	ctd:C071482
Disease	hypertension	PDE3A PBRM1 SZT2 KCP NUP160	2.06e-04	307	52	5	EFO_0000537
Disease	colon adenocarcinoma (is_implicated_in)	ABHD5 BAX	9.64e-04	26	52	2	DOID:234 (is_implicated_in)
Disease	Breast adenocarcinoma	PBRM1 PIK3CB	2.39e-03	41	52	2	C0858252
Disease	Neoplasm of uncertain or unknown behavior of breast	PBRM1 PIK3CB	2.39e-03	41	52	2	C0496956

Protein segments in the cluster

Peptide	Gene	Start	Entry
MWLGRRALCALVLLL	B4GALNT1	1	Q00973
MRSILLDWLLEVCEV	CCNE2	141	O96020
ELLRMELAILDRLHW	CCNI2	231	Q6ZMN8
VFLILRIWVVLRSMD	ALG14	16	Q96F25
RGELESRWEKLRGLM	CCDC154	276	A6NI56
ADKLGRLWRLQERLM	CDAN1	536	Q8IWY9
RLLILVGRLFMWEEP	APOBEC2	146	Q9Y235
LRDVREVWEMLGPRI	ABCA7	321	Q8IZY2
IVDSILMERRIRPWI	RBM25	761	P49756
LWRLRDLMLRDTLNI	PBRM1	1666	Q86U86
VVALRDGKLCLMWRV	KCNJ12	201	Q14500
ELRLVAVDRLMEWLL	MSS51	151	Q4VC12
FLGLLRLIREMEAWA	PNMA6E	481	A0A0J9YXQ4
LLRLIRDMEAWAASL	PNMA6F	416	A0A0J9YX94
MDLEWRQGRIARVVL	PLXNA2	1551	O75051
ATWLVLRLRLGVLMI	PDE3A	201	Q14432
LWQMRRQLLLELMGI	INTS2	336	Q9H0H0
MVELRLRLELVRPGW	KIF7	531	Q2M1P5
RVILWLMVELAIIGS	SLC11A2	146	P49281
LRELERMLELGWEAL	GOLGA6L9	306	A6NEM1
LRELERMLELGWEAL	GOLGA6L10	396	A6NI86
LERLRELERMLELGW	GOLGA6L19	421	H0YKK7
MELGLRWVFLVAILE	IGHV3-21	1	A0A0B4J1V1
LIDALDTMWILGLRK	MAN1B1	291	Q9UKM7
SLGMLRELMVVIRIW	MED16	651	Q9Y2X0
LGNLLIMATVWIERR	OR10H3	41	O60404
DLVIIWLRDMRLMQG	UPF1	356	Q92900
MWAVGCILAELLLRV	CDK7	196	P50613
ELIRTIMGWTLDFLR	BAX	131	Q07812
KLELIMRAEGGLWLR	CYP4F12	501	Q9HCS2
VRDLLPVWLLEDMRA	ANKRD9	41	Q96BM1
AVLLRMAEQLAWLRV	BRF2	271	Q9HAW0
VGRLWLVVMLIFRIL	GJD3	21	Q8N144
LLNRELRAMLAIEDW	EHBP1	1151	Q8NDI1
RWAILAMVLGSVLLL	DSC1	691	Q08554
RWLLTRGRMDEAIQL	SLC22A13	276	Q9Y226
MLLEDAWRELFVLGI	NR2E1	216	Q9Y466
EIRWLLEDEMVGALR	SZT2	1696	Q5T011
VVALRDGKLCLMWRV	KCNJ18	201	B7U540
LLALRTVLGGMEVRW	MELTF	11	P08582
LREWLGRLEAAVMEL	KCP	56	Q6ZWJ8
ILNLVMVGLVSRLWV	NEPRO	171	Q6NW34
WLTRIRLSIMRVGLL	SMG1	1026	Q96Q15
AEMLHRGRMLWIILL	SLITRK3	6	O94933
RGRMLWIILLSTIAL	SLITRK3	11	O94933
LCGLLKMWEDLRLRV	SHCBP1L	346	Q9BZQ2
LLRVWGRIAAVMADV	SBNO2	1171	Q9Y2G9
RLMDLLWKEAGLDLR	PIK3CB	821	P42338
ILQQLLMRLGDAVIW	NUP160	736	Q12769
EEWRCALGLDKMILL	ABHD5	136	Q8WTS1
TGLGRVMRTLLLVLW	TMED9	16	Q9BVK6
VMRTLLLVLWLATRG	TMED9	21	Q9BVK6
LDSIIARRWINGMLI	UBA3	166	Q8TBC4
RTRLMELHRQWELLL	SPTAN1	121	Q13813
RWIAFAVMIVLALIR	TMEM104	241	Q8NE00
LLVILAMGLWVIRVQ	SLAMF9	246	Q96A28
MRGELWLLVLVLREA	PLXDC1	1	Q8IUK5
LIRELAWEGLKRLGM	WDR87	936	Q6ZQQ6
RVELRDMVVALLEVW	USP32	286	Q8NFA0
RVRIKEVDGWTLRML	KLHL2	96	O95198