Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionG protein-coupled receptor activity

OR4K13 OR4N4 OR9I1 MRGPRX1 P2RY13 OR6C68 OR4F21 AR OR4F15

1.58e-04884469GO:0004930
GeneOntologyCellularComponentsite of polarized growth

LRIG2 GDPD5 SHANK2 RAPGEF3 RAPGEF4 FRYL

2.37e-05253486GO:0030427
GeneOntologyCellularComponentbasolateral part of cell

RAPGEF3 KCNQ1

3.09e-054482GO:1990794
GeneOntologyCellularComponentlateral part of cell

RAPGEF3 KCNQ1

1.43e-048482GO:0097574
GeneOntologyCellularComponentbasal plasma membrane

SLC4A7 DST RAPGEF3 RAPGEF4 KCNQ1 HEPH

1.52e-04354486GO:0009925
GeneOntologyCellularComponentcluster of actin-based cell projections

SLC4A7 SHANK2 RAPGEF3 RAPGEF4 PKHD1L1

1.56e-04223485GO:0098862
GeneOntologyCellularComponentaxon

LRIG2 GDPD5 DST SHANK2 RAPGEF3 MRGPRX1 RAPGEF4 DSCAML1 AR

1.67e-04891489GO:0030424
GeneOntologyCellularComponentbasal part of cell

SLC4A7 DST RAPGEF3 RAPGEF4 KCNQ1 HEPH

2.17e-04378486GO:0045178
GeneOntologyCellularComponentgrowth cone

LRIG2 GDPD5 SHANK2 RAPGEF3 RAPGEF4

2.41e-04245485GO:0030426
GeneOntologyCellularComponentperinuclear endoplasmic reticulum

GDPD5 DST

2.01e-0329482GO:0097038
DomainARM-type_fold

THADA ATR DAAM2 FRYL ARMCX5 GCN1

1.96e-04339476IPR016024
Domain-

ATR DAAM2 FRYL ARMCX5 GCN1

2.32e-042224751.25.10.10
DomainGPCR_Rhodpsn_7TM

OR4K13 OR4N4 OR9I1 MRGPRX1 P2RY13 OR6C68 OR4F21 OR4F15

2.40e-04670478IPR017452
Domain7tm_1

OR4K13 OR4N4 OR9I1 MRGPRX1 P2RY13 OR6C68 OR4F21 OR4F15

2.57e-04677478PF00001
DomainG_PROTEIN_RECEP_F1_1

OR4K13 OR4N4 OR9I1 MRGPRX1 P2RY13 OR6C68 OR4F21 OR4F15

2.78e-04685478PS00237
DomainG_PROTEIN_RECEP_F1_2

OR4K13 OR4N4 OR9I1 MRGPRX1 P2RY13 OR6C68 OR4F21 OR4F15

2.95e-04691478PS50262
DomainGPCR_Rhodpsn

OR4K13 OR4N4 OR9I1 MRGPRX1 P2RY13 OR6C68 OR4F21 OR4F15

2.98e-04692478IPR000276
DomainOlfact_rcpt

OR4K13 OR4N4 OR9I1 OR6C68 OR4F21 OR4F15

4.33e-04393476IPR000725
DomainRas_G-nucl-exch_fac_CS

RAPGEF3 RAPGEF4

5.53e-0414472IPR019804
DomainARM-like

ATR DAAM2 FRYL ARMCX5 GCN1

5.68e-04270475IPR011989
DomainHEAT_type_2

ATR GCN1

8.23e-0417472IPR021133
DomainRasGEFN

RAPGEF3 RAPGEF4

1.14e-0320472SM00229
DomainRasGEF_N

RAPGEF3 RAPGEF4

1.26e-0321472PF00618
DomainDEP

RAPGEF3 RAPGEF4

1.39e-0322472PF00610
DomainRas-like_Gua-exchang_fac_N

RAPGEF3 RAPGEF4

1.39e-0322472IPR000651
DomainDEP

RAPGEF3 RAPGEF4

1.39e-0322472PS50186
DomainRASGEF_NTER

RAPGEF3 RAPGEF4

1.39e-0322472PS50212
DomainCupredoxin

PKHD1L1 HEPH

1.39e-0322472IPR008972
DomainDEP

RAPGEF3 RAPGEF4

1.39e-0322472SM00049
DomainDEP_dom

RAPGEF3 RAPGEF4

1.52e-0323472IPR000591
DomainRASGEF

RAPGEF3 RAPGEF4

1.94e-0326472PS00720
DomainRASGEF_CAT

RAPGEF3 RAPGEF4

2.41e-0329472PS50009
DomainRasGEF

RAPGEF3 RAPGEF4

2.58e-0330472PF00617
Domain-

RAPGEF3 RAPGEF4

2.58e-03304721.10.840.10
DomainRas_GEF_dom

RAPGEF3 RAPGEF4

2.58e-0330472IPR023578
DomainRASGEF_cat_dom

RAPGEF3 RAPGEF4

2.58e-0330472IPR001895
DomainRasGEF

RAPGEF3 RAPGEF4

2.58e-0330472SM00147
DomainCNMP_BINDING_1

RAPGEF3 RAPGEF4

2.93e-0332472PS00888
DomainCNMP_BINDING_2

RAPGEF3 RAPGEF4

2.93e-0332472PS00889
DomaincNMP

RAPGEF3 RAPGEF4

3.30e-0334472SM00100
DomaincNMP_binding

RAPGEF3 RAPGEF4

3.30e-0334472PF00027
DomaincNMP-bd_dom

RAPGEF3 RAPGEF4

3.50e-0335472IPR000595
DomainCNMP_BINDING_3

RAPGEF3 RAPGEF4

3.50e-0335472PS50042
DomaincNMP-bd-like

RAPGEF3 RAPGEF4

4.11e-0338472IPR018490
DomainArmadillo

ARMCX5 GCN1

6.23e-0347472IPR000225
DomainHEAT

ATR GCN1

6.49e-0348472PF02985
Domain-

RAPGEF3 RAPGEF4

6.49e-03484722.60.120.10
DomainRmlC-like_jellyroll

RAPGEF3 RAPGEF4

7.31e-0351472IPR014710
DomainVWA

PARP4 VWA8

8.75e-0356472PF00092
DomainHEAT

ATR GCN1

9.37e-0358472IPR000357
Pubmed

Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression.

RAPGEF3 RAPGEF4

1.94e-06249228821815
Pubmed

β-Adrenergic Receptors/Epac Signaling Increases the Size of the Readily Releasable Pool of Synaptic Vesicles Required for Parallel Fiber LTP.

RAPGEF3 RAPGEF4

1.94e-06249233046543
Pubmed

Renal expression of exchange protein directly activated by cAMP (Epac) 1 and 2.

RAPGEF3 RAPGEF4

1.94e-06249218495799
Pubmed

Anxiety and depression with neurogenesis defects in exchange protein directly activated by cAMP 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, Prozac.

RAPGEF3 RAPGEF4

1.94e-06249227598965
Pubmed

Mice depleted for Exchange Proteins Directly Activated by cAMP (Epac) exhibit irregular liver regeneration in response to partial hepatectomy.

RAPGEF3 RAPGEF4

1.94e-06249231551444
Pubmed

EPAC Negatively Regulates Myelination via Controlling Proliferation of Oligodendrocyte Precursor Cells.

RAPGEF3 RAPGEF4

1.94e-06249232303914
Pubmed

B cell receptor-induced growth arrest and apoptosis in WEHI-231 immature B lymphoma cells involve cyclic AMP and Epac proteins.

RAPGEF3 RAPGEF4

1.94e-06249219167486
Pubmed

Exchange Proteins Directly Activated by cAMP and Their Roles in Respiratory Syncytial Virus Infection.

RAPGEF3 RAPGEF4

1.94e-06249230185593
Pubmed

Epac Signaling Is Required for Cocaine-Induced Change in AMPA Receptor Subunit Composition in the Ventral Tegmental Area.

RAPGEF3 RAPGEF4

1.94e-06249227122037
Pubmed

Epac1-/- and Epac2-/- mice exhibit deficient epithelial Na+ channel regulation and impaired urinary Na+ conservation.

RAPGEF3 RAPGEF4

1.94e-06249234914636
Pubmed

EPAC Regulates Melanoma Growth by Stimulating mTORC1 Signaling and Loss of EPAC Signaling Dependence Correlates with Melanoma Progression.

RAPGEF3 RAPGEF4

1.94e-06249235834616
Pubmed

Exchange protein directly activated by cAMP (Epac) protects against airway inflammation and airway remodeling in asthmatic mice.

RAPGEF3 RAPGEF4

1.94e-06249231852500
Pubmed

Epac2-deficiency leads to more severe retinal swelling, glial reactivity and oxidative stress in transient middle cerebral artery occlusion induced ischemic retinopathy.

RAPGEF3 RAPGEF4

1.94e-06249225985753
Pubmed

The cAMP sensors, EPAC1 and EPAC2, display distinct subcellular distributions despite sharing a common nuclear pore localisation signal.

RAPGEF3 RAPGEF4

1.94e-06249225683912
Pubmed

Urinary concentrating defect in mice lacking Epac1 or Epac2.

RAPGEF3 RAPGEF4

1.94e-06249230252533
Pubmed

Origin and Isoform Specific Functions of Exchange Proteins Directly Activated by cAMP: A Phylogenetic Analysis.

RAPGEF3 RAPGEF4

1.94e-06249234685730
Pubmed

Role of dynamics in the autoinhibition and activation of the exchange protein directly activated by cyclic AMP (EPAC).

RAPGEF3 RAPGEF4

1.94e-06249221873431
Pubmed

Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B.

RAPGEF3 RAPGEF4

1.94e-06249226269639
Pubmed

Inhibition of EPAC1 signaling pathway alters atrial electrophysiology and prevents atrial fibrillation.

RAPGEF3 RAPGEF4

1.94e-06249236909224
Pubmed

Increased microvascular permeability in mice lacking Epac1 (Rapgef3).

RAPGEF3 RAPGEF4

1.94e-06249227096875
Pubmed

Possible role of the exchange protein directly activated by cyclic AMP (Epac) in the cyclic AMP-dependent functional differentiation and syncytialization of human placental BeWo cells.

RAPGEF3 RAPGEF4

1.94e-06249220663796
Pubmed

Deletion of exchange proteins directly activated by cAMP (Epac) causes defects in hippocampal signaling in female mice.

RAPGEF3 RAPGEF4

1.94e-06249230048476
Pubmed

Evidence for existence of cAMP-Epac signaling in the heads of mouse epididymal spermatozoa.

RAPGEF3 RAPGEF4

1.94e-06249217077580
Pubmed

The role of Epac in the heart.

RAPGEF3 RAPGEF4

1.94e-06249227549789
Pubmed

Insights into exchange factor directly activated by cAMP (EPAC) as potential target for cancer treatment.

RAPGEF3 RAPGEF4

1.94e-06249229417338
Pubmed

Structure and regulation of the cAMP-binding domains of Epac2.

RAPGEF3 RAPGEF4

1.94e-06249212469113
Pubmed

Epac: new emerging cAMP-binding protein.

RAPGEF3 RAPGEF4

1.94e-06249233298248
Pubmed

Epac1 inhibition ameliorates pathological angiogenesis through coordinated activation of Notch and suppression of VEGF signaling.

RAPGEF3 RAPGEF4

1.94e-06249231911948
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

GDPD5 THADA DST SHANK2 VWA8 XXYLT1 FRYL SYVN1 GCN1 RASD2

2.68e-061105491035748872
Pubmed

Exchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca2+-dependent K+ channels in cerebellar neurons.

RAPGEF3 RAPGEF4

5.83e-06349217284589
Pubmed

Deficiency of the purine metabolic gene HPRT dysregulates microRNA-17 family cluster and guanine-based cellular functions: a role for EPAC in Lesch-Nyhan syndrome.

RAPGEF3 RAPGEF4

5.83e-06349223804752
Pubmed

EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation.

RAPGEF3 RAPGEF4

5.83e-06349222365550
Pubmed

A family of cAMP-binding proteins that directly activate Rap1.

RAPGEF3 RAPGEF4

5.83e-0634929856955
Pubmed

EPAC inhibition of SUR1 receptor increases glutamate release and seizure vulnerability.

RAPGEF3 RAPGEF4

5.83e-06349223678128
Pubmed

Anti-inflammatory role of the cAMP effectors Epac and PKA: implications in chronic obstructive pulmonary disease.

RAPGEF3 RAPGEF4

5.83e-06349222363678
Pubmed

Exchange protein directly activated by cAMP (EPAC) interacts with the light chain (LC) 2 of MAP1A.

RAPGEF3 RAPGEF4

5.83e-06349215202935
Pubmed

Epac1 and Epac2 are differentially involved in inflammatory and remodeling processes induced by cigarette smoke.

RAPGEF3 RAPGEF4

5.83e-06349225103224
Pubmed

The Epac-Phospholipase Cε Pathway Regulates Endocannabinoid Signaling and Cocaine-Induced Disinhibition of Ventral Tegmental Area Dopamine Neurons.

RAPGEF3 RAPGEF4

5.83e-06349228209735
Pubmed

Usefulness of Exchanged Protein Directly Activated by cAMP (Epac)1-Inhibiting Therapy for Prevention of Atrial and Ventricular Arrhythmias in Mice.

RAPGEF3 RAPGEF4

5.83e-06349230518738
Pubmed

Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses.

RAPGEF3 RAPGEF4

5.83e-06349224892712
Pubmed

cAMP-Epac2-mediated activation of Rap1 in developing male germ cells: RA-RhoGAP as a possible direct down-stream effector.

RAPGEF3 RAPGEF4

1.16e-05449218937323
Pubmed

Targeting DNA Damage Response in Prostate Cancer by Inhibiting Androgen Receptor-CDC6-ATR-Chk1 Signaling.

ATR AR

1.16e-05449228228262
Pubmed

CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation.

RAPGEF3 RAPGEF4

1.16e-05449215334074
Pubmed

A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia.

RAPGEF3 RAPGEF4

1.94e-0554929789079
Pubmed

NRIP/DCAF6 stabilizes the androgen receptor protein by displacing DDB2 from the CUL4A-DDB1 E3 ligase complex in prostate cancer.

CUL4A AR

1.94e-05549228212551
Pubmed

Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs.

RAPGEF3 RAPGEF4

1.94e-05549210777494
Pubmed

Activation of EPAC1/2 is essential for osteoclast formation by modulating NFκB nuclear translocation and actin cytoskeleton rearrangements.

RAPGEF3 RAPGEF4

1.94e-05549225122553
Pubmed

Epac2 mediates cardiac β1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia.

RAPGEF3 RAPGEF4

1.94e-05549223363625
Pubmed

The human immunodeficiency virus type 1 Vpr protein upregulates PVR via activation of the ATR-mediated DNA damage response pathway.

CUL4A ATR

1.94e-05549224045107
Pubmed

Neuronal AKAP150 coordinates PKA and Epac-mediated PKB/Akt phosphorylation.

RAPGEF3 RAPGEF4

1.94e-05549218565730
Pubmed

A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.

USP31 SHANK2 TRPM3 NOL6 KCNQ1 ARMCX5

2.70e-0542049628065597
Pubmed

Developmental changes in gene expression of Epac and its upregulation in myocardial hypertrophy.

RAPGEF3 RAPGEF4

2.91e-05649217557924
Pubmed

Ras and relatives--job sharing and networking keep an old family together.

RAPGEF3 RAPGEF4

2.91e-05649212384139
Pubmed

Novel Rap1 dominant-negative mutants interfere selectively with C3G and Epac.

RAPGEF3 RAPGEF4

2.91e-05649215856025
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

LRIG2 USP31 THADA SLC4A7 AFTPH VWA8 ST7 MRPS16 AIP HERC5

3.54e-051487491033957083
Pubmed

HIV-1 Vpr up-regulates expression of ligands for the activating NKG2D receptor and promotes NK cell-mediated killing.

CUL4A ATR

4.07e-05749220008788
Pubmed

Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions.

RAPGEF3 RAPGEF4

4.07e-05749216076873
Pubmed

HIV-1 Vpr triggers natural killer cell-mediated lysis of infected cells through activation of the ATR-mediated DNA damage response.

CUL4A ATR

4.07e-05749219798433
Pubmed

Small molecule NSC1892 targets the CUL4A/4B-DDB1 interactions and causes impairment of CRL4DCAF4 E3 ligases to inhibit colorectal cancer cell growth.

CUL4A ST7

4.07e-05749232140073
Pubmed

Sex Hormones Regulate SHANK Expression.

SHANK2 AR

5.42e-05849230319350
Pubmed

Prostaglandin E2 reduces the release and infectivity of new cell-free virions and cell-to-cell HIV-1 transfer.

RAPGEF3 RAPGEF4

6.96e-05949224586238
Pubmed

Cullin4 E3 Ubiquitin Ligases Regulate Male Gonocyte Migration, Proliferation and Blood-Testis Barrier Homeostasis.

CUL4A AR

8.69e-051049234685710
Pubmed

HIV-1 Vpr: mechanisms of G2 arrest and apoptosis.

CUL4A ATR

8.69e-051049218514189
Pubmed

The functions of the HIV1 protein Vpr and its action through the DCAF1.DDB1.Cullin4 ubiquitin ligase.

CUL4A ATR

8.69e-051049220347598
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

LRIG2 THADA SLC4A7 DST NOL6 GCN1 PKHD1L1

1.03e-0477749735844135
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

THADA DST VWA8 ST7 NOL6 MRPS16 UBN2 GCN1 HERC5

1.60e-04144049930833792
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

PARP4 ATR FRYL GCN1

1.91e-0420249433005030
Pubmed

FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator).

ATR GCN1

2.02e-041549227365398
Pubmed

Differential impact of tetratricopeptide repeat proteins on the steroid hormone receptors.

AIP AR

2.02e-041549220661446
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

CUL4A THADA SHANK2 PDE9A ST7 XXYLT1 FRYL UBN2 AR

2.06e-04148949928611215
Pubmed

HIV-1 Vpr-a still "enigmatic multitasker".

CUL4A ATR

2.30e-041649224744753
Pubmed

Structure-function relationship of Vpr: biological implications.

CUL4A ATR

2.30e-041649219275588
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

FRYL GCN1 DSCAML1

2.56e-048749312465718
Pubmed

Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.

THADA KCNQ1

2.61e-041749219741467
Pubmed

Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.

THADA KCNQ1

2.61e-041749219502414
Pubmed

HERC5/IFI16/p53 signaling mediates breast cancer cell proliferation and migration.

CUL4A SYVN1 HERC5

2.83e-049049335671810
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

DST GCN1 DSCAML1 HEPH

2.88e-0422549412168954
Pubmed

Neuronal Rap1 Regulates Energy Balance, Glucose Homeostasis, and Leptin Actions.

RAPGEF3 RAPGEF4

2.93e-041849227626668
Pubmed

Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor.

CUL4A PARP4

2.93e-041849225117710
Pubmed

Dioxin receptor is a ligand-dependent E3 ubiquitin ligase.

CUL4A AR

3.27e-041949217392787
Pubmed

Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI.

THADA KCNQ1

3.64e-042049219933996
Pubmed

The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation.

CUL4A VWA8 NOL6 HERC5

4.48e-0425349429911972
Pubmed

Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.

CUL4A ST7 NOL6 SYVN1

4.75e-0425749430945288
Pubmed

FAM105A/OTULINL Is a Pseudodeubiquitinase of the OTU-Class that Localizes to the ER Membrane.

LRIG2 SLC4A7 ST7 UGT8 SYVN1

5.06e-0446849531056421
Pubmed

Impact of single nucleotide polymorphisms and of clinical risk factors on new‐onset diabetes mellitus in HIV‐infected individuals.

THADA KCNQ1

5.71e-042549220879858
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

LRIG2 PARP4 THADA TRPM3 UBN2

6.40e-0449349515368895
Pubmed

Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight.

THADA KCNQ1

6.67e-042749220490451
Pubmed

Vpr and its interactions with cellular proteins.

CUL4A ATR

7.18e-042849220012529
Pubmed

Obesity and diabetes genetic variants associated with gestational weight gain.

THADA KCNQ1

7.71e-042949220816152
Pubmed

Mitochondrial Fission Factor Is a Novel Interacting Protein of the Critical B Cell Survival Regulator TRAF3 in B Lymphocytes.

SLC4A7 PDE9A

8.25e-043049234745083
Pubmed

Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.

DST VWA8 DSCAML1

8.29e-0413049312421765
Pubmed

Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.

LRIG2 THADA DAAM2 SYVN1 UBN2

9.08e-0453349525544563
Pubmed

Genome-wide association study of lung function decline in adults with and without asthma.

PDE9A HERC5

9.39e-043249222424883
Pubmed

Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk.

THADA KCNQ1

9.98e-043349220203524
Pubmed

The intracellular NADH level regulates atrophic nonunion pathogenesis through the CtBP2-p300-Runx2 transcriptional complex.

CUL4A ATR UGT8

1.11e-0314449330585266
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

CUL4A USP31 SLC4A7 DST AFTPH FRYL

1.28e-0386149636931259
Pubmed

The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.

LRIG2 ATR UBN2

1.30e-0315249338360978
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR9I1 OR6C68 OR4F21 OR4F15

1.34e-0334049411875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR9I1 OR6C68 OR4F21 OR4F15

1.34e-0334049411802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR9I1 OR6C68 OR4F21 OR4F15

1.39e-0334349432295537
CytobandEnsembl 112 genes in cytogenetic band chrXq12

AR HEPH

3.57e-0426492chrXq12
CytobandEnsembl 112 genes in cytogenetic band chr11q13

GDPD5 SHANK2 AIP SYVN1

1.41e-03454494chr11q13
CytobandEnsembl 112 genes in cytogenetic band chr1p13

LRIG2 AMPD1 SLC6A17

1.51e-03211493chr1p13
GeneFamilyOlfactory receptors, family 4

OR4K13 OR4N4 OR4F21 OR4F15

7.62e-05129324151
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

THADA ARMCX5

2.62e-0343322409
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC4A7 PDE9A UGT8 KCNQ1 DSCAML1

1.13e-06175475e5467dacf81f1f913b1719931cf1a7331434a7e7
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SLC4A7 PDE9A VWA8 UGT8 KCNQ1

1.30e-061804759e09b3dfe344b5d50520711513d389865d73a861
ToppCellCOVID-19-kidney-Mito-rich_Distal|COVID-19 / Disease (COVID-19 only), tissue and cell type

SHANK2 PDE9A RAPGEF3 UGT8 DSCAML1

1.74e-061914750965f621ebcd92ccdeb21cc27022180ce3cfe910
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC4A7 SHANK2 PDE9A UGT8 KCNQ1

1.97e-06196475eea66711a16134f86e6c533a5a837ff2e0d7ca7f
ToppCell367C-Lymphocytic-CD4_T-cell-Treg_cell_3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

THADA TRPM3 VWA8 AR

2.50e-0516147422fea192cd5f6d3544533d8b10e1d74dfedf0f05
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM3 RAPGEF4 DAAM2 HEPH

2.50e-051614741b805f77790aeb8a71b08bfac2fe2eed7343258f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A17 RAPGEF4 DAAM2 RASD2

2.69e-0516447443630a448f4369fa9e4e3eccdf3b9f29cec16c39
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A17 RAPGEF4 DAAM2 RASD2

2.69e-05164474108fbecb56d69a675d6ce6e826a873ae528f2fd7
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC6A17 RAPGEF4 DAAM2 RASD2

2.69e-0516447446208f18325976c89f572f6627aea0582142b92d
ToppCellCOVID-19-kidney-PEC|COVID-19 / Disease (COVID-19 only), tissue and cell type

SHANK2 TRPM3 RAPGEF3 DSCAML1

2.95e-05168474a086c306be430adf0632ba53e98cd8014d2de330
ToppCellControl-Epithelial_alveolar-AT_1-Differentiating_AT1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHANK2 TRPM3 DAAM2 DSCAML1

3.62e-051774749af14a056eb6d88c6f11b09f6d4c0d3448d647d5
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP31 SLC4A7 DST TRPM3

3.70e-05178474fcbbcc44271515de1969b4732b6441c012693d5f
ToppCellfacs-Heart-LV-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ASPN SLC6A17 DAAM2 RASD2

3.78e-051794748da6863edc756540bb097cc7221c1408640d9bb4
ToppCellfacs-Heart-LV-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ASPN SLC6A17 DAAM2 RASD2

3.78e-05179474f39c13c99a07d009cc677e363ffe089089c64916
ToppCelldroplet-Heart-nan-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ASPN SLC6A17 DAAM2 RASD2

3.86e-0518047478fdcfb3fdbf36469cae78407cda5bd0996930d8
ToppCellCOVID-19-kidney-Distal_Epi_Doublet_(PCT)|COVID-19 / Disease (COVID-19 only), tissue and cell type

SHANK2 TRPM3 UGT8 DSCAML1

4.03e-051824749d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM3 SLC6A17 PKHD1L1 DSCAML1

4.21e-05184474ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM3 SLC6A17 PKHD1L1 DSCAML1

4.21e-051844742cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRPM3 SLC6A17 PKHD1L1 DSCAML1

4.21e-051844742b19a8c5f823e00812908b23e66bb4e563278aff
ToppCelldroplet-Heart-nan-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ASPN SLC6A17 DAAM2 RASD2

4.21e-05184474f4344f3c407b2d4d703fe56e43d84dbfe60ba833
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC4A7 PDE9A VWA8 UGT8

4.30e-0518547403f64a7132b13a01ba47187e0e15c13ac88f7cb2
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC4A7 PDE9A VWA8 UGT8

4.39e-051864741850583d23903d08226aeb0edb3e07b0994330e4
ToppCelldroplet-Bladder-Unstain-18m-Endothelial-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RAPGEF3 ASPN RAPGEF4 KCNQ1

4.39e-05186474e3a14f3ccadbf3211822c67b8956ee01f563307a
ToppCellTCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma-2|TCGA-Kidney / Sample_Type by Project: Shred V9

ASPN DAAM2 HEPH RASD2

4.39e-051864741e6526fc9e9381b7ace864588cc7bd80194338d6
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC4A7 PDE9A VWA8 UGT8

4.39e-051864744dafc215c42e7949f932a3627359c107943b5d6b
ToppCellCOVID-19-kidney|COVID-19 / Disease (COVID-19 only), tissue and cell type

SHANK2 TRPM3 UGT8 DSCAML1

4.48e-05187474d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCellCOVID-19-kidney-CD-PC|COVID-19 / Disease (COVID-19 only), tissue and cell type

SHANK2 PDE9A TRPM3 RAPGEF3

4.58e-051884748f9996c3f3b27efaaae8960a66af77412de9c7ef
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC4A7 DST RAPGEF4 UBN2

4.58e-05188474a91443aa8fa8fa87f7501c59219daa0305bd0bbf
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

RAPGEF3 UGT8 DAAM2 HEPH

4.77e-051904742de8e4cfeee350a9a76af749d6ce58d948c129b8
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC4A7 SHANK2 PDE9A KCNQ1

4.87e-051914743e828cffa24ded19f591a7ed6c1fe88ad57fdcac
ToppCelldroplet-Pancreas-Endocrine-18m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC4A7 DST RAPGEF4 UBN2

4.87e-05191474fd01a206763dfb6d52cca67123571936b4a8e1a0
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC4A7 PDE9A RAPGEF3 UGT8

4.87e-051914745a67ff17fb4b9eff641176dff07830c9cd73754e
ToppCellCOVID-19-kidney-TAL|COVID-19 / Disease (COVID-19 only), tissue and cell type

SHANK2 PDE9A RAPGEF3 UGT8

4.87e-05191474fe55475ce0666ab5122447a813dc2369e24947b8
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC4A7 PDE9A RAPGEF3 UGT8

4.87e-0519147455ab2854a02cdcfc395e49870ccb7290b5e5471d
ToppCelldroplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC4A7 DST RAPGEF4 UBN2

4.97e-051924741304e69c92cef3bd8c82e3c035a7562f5440139a
ToppCell356C-Epithelial_cells-Epithelial-H_(AT1)-|356C / Donor, Lineage, Cell class and subclass (all cells)

PDE9A ST7 SYVN1 GCN1

5.17e-051944744c40d6b50675eae52c419d69e719a9223df02ae3
ToppCell356C-Epithelial_cells-Epithelial-H_(AT1)|356C / Donor, Lineage, Cell class and subclass (all cells)

PDE9A ST7 SYVN1 GCN1

5.17e-0519447499a90de637e3babec2131cdd9f05ea965d8a8f30
ToppCelldroplet-Bladder-Unstain-18m-Endothelial-endothelial_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ASPN SLC6A17 RAPGEF4 KCNQ1

5.27e-051954742a6056172c41c46acfe0242be22269ef1d07921e
ToppCelldroplet-Bladder-Unstain-18m-Endothelial|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ASPN SLC6A17 RAPGEF4 KCNQ1

5.27e-05195474fbfe4a8ae9775764108b45920eec92003b24fb2e
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC4A7 DST RAPGEF4 FRYL

5.27e-051954743e519cffa6144a62b06124642a14c9ff39b76554
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC4A7 DST RAPGEF4 FRYL

5.27e-051954747796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Pericyte-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ASPN DAAM2 HEPH RASD2

5.49e-051974742872a78b1be61aa1d50bc9a49294a21e922dc033
ToppCellMacroglial|World / cells hierarchy compared to all cells using T-Statistic

RAPGEF3 UGT8 DAAM2 HEPH

5.82e-05200474e6935ad49216d2500c15c05cbc2b89402c65e838
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Neuronal-Intermediate|GW19 / Sample Type, Dataset, Time_group, and Cell type.

ASPN KCNQ1 AR

2.75e-04120473eb5b88c47dd4a6f9b55ace24f19d4e81d4ed31e1
ToppCelldroplet-Pancreas-Endocrine-18m-Epithelial-pancreatic_ductal_cel|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDE9A DSCAML1 HEPH

5.19e-041494737726957b1de638c3bfc659381d15eab626bb179b
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PDE9A TRPM3 SLC6A17

5.39e-04151473f4f7156b2c0cfc78fd1841e07c9915d97ced561f
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

P2RY13 KCNQ1 HEPH

5.71e-04154473c6ecc46b99a783373729f7fae0b23216148ffb78
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-AT1|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHANK2 TRPM3 DSCAML1

6.04e-041574739665a1375cfd8e9b8781c852686591226c0e0d9a
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Tubular-6|TCGA-Stomach / Sample_Type by Project: Shred V9

ATR NOL6 GCN1

6.27e-04159473655c0749c238bd68cb797adb83e25a23b8a3cc9d
ToppCellTCGA-Mesothelium-Primary_Tumor-Mesothelioma-Epitheliod-2|TCGA-Mesothelium / Sample_Type by Project: Shred V9

GDPD5 PKHD1L1 DSCAML1

6.38e-04160473d288b0a315f6adc0be4bdc89fa67bf93679a743f
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1-AT1|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHANK2 TRPM3 DSCAML1

6.50e-041614731e17a993126e1f2a25ee7dfbb95a74ccb2a26791
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_ductal_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SHANK2 UGT8 KCNQ1

6.61e-041624733a1cbfed5a063131d49e3c1584f62b12660ecb36
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_ductal_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SHANK2 UGT8 KCNQ1

6.61e-0416247304b3c38bb27fa369a9ac5b60883f8b058abc5180
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM3 RAPGEF3 KCNQ1

6.61e-04162473285e6d553f485fd9f1075c4e1b940da251b5ea35
ToppCellTCGA-Uterus-Primary_Tumor-Uterine_Carcinoma-Uterine_Carcinosarcoma-3|TCGA-Uterus / Sample_Type by Project: Shred V9

DST FRYL AR

6.73e-04163473d64dd39b077105c73e570ccef70f0e74a2c586ac
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

AFTPH UGT8 DSCAML1

6.73e-04163473cab65dabeea58141c649e4fec5e0123beb3de1b3
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PARP4 SHANK2 DSCAML1

6.85e-041644731cb5fbd7050650047ad6f2ca792118e98d58d22b
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

GDPD5 PKHD1L1 HEPH

6.85e-041644738f074940afdbda88a4b697a7ddc687e09a4b818b
ToppCell343B-Lymphocytic-Plasma_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

AMPD1 RAPGEF4 PKHD1L1

6.85e-04164473cf62d34ce9dd220fe61748466c84fd70d9ba697c
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

GDPD5 PKHD1L1 HEPH

6.85e-04164473a784f47f67a5eda84d58ad7d9400e3978edbb487
ToppCell343B-Lymphocytic-Plasma_cell-|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

AMPD1 RAPGEF4 PKHD1L1

6.85e-04164473e00549bc8b3a5566f39031f39d7e698b0b107a7f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM3 RAPGEF3 KCNQ1

6.85e-041644736fb2136168f430babfeb81ca7e151ca7a8092ec4
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

GDPD5 PKHD1L1 HEPH

6.85e-041644731a1795969673232191425dde84ab24ee6a98143f
ToppCellCOVID-19-lung-Mesothelial|COVID-19 / Disease (COVID-19 only), tissue and cell type

GDPD5 PKHD1L1 DSCAML1

6.85e-0416447383303e2ba52008391b8dc3fae8225ab5bcb20063
ToppCellCerebellum-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Cerebellum / BrainAtlas - Mouse McCarroll V32

GDPD5 SHANK2 AR

7.22e-041674739efb9511a211d0824bb97f82c1a5860c43d2138f
ToppCellCerebellum-Neuronal-Inhibitory|Cerebellum / BrainAtlas - Mouse McCarroll V32

GDPD5 SHANK2 AR

7.22e-04167473904c613aac3f9919a432b110bb1dcc832b5aec0a
ToppCellPND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

THADA TRPM3 RASD2

7.35e-0416847308f6e171a1ea5cf65149744296d0fcd6c7b9684e
ToppCelldroplet-Thymus-nan-21m-Lymphocytic-Macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP31 VWA8 P2RY13

7.74e-04171473a474aaed3ca4cacb0ab565c35f25d92a10f531b7
ToppCellwk_20-22-Mesenchymal-Chondrocyte|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

ASPN DAAM2 AR

7.74e-04171473d2938639e9a7c349e5a6ec61724222f9d127c89f
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM3 OR9I1 DAAM2

7.87e-04172473553701349444eb366df3c11f54bb093434f153c6
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TRPM3 OR9I1 DAAM2

7.87e-0417247308a3fe536b1b064c5ee7779bc2b1115a5963a26b
ToppCellBronchial_Biopsy-Endothelial-Lymphatic|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

PDE9A PKHD1L1 HERC5

7.87e-04172473c41f5a66781bbf63afce7ca5d118cc6d8e0fe0bc
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SLC4A7 PDE9A UGT8

7.87e-041724731565f38266891c3acf49778838de134c5dee5460
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

GOT1L1 ASPN DAAM2

8.00e-041734731f16d47f5548e257e4b17f8070c5619780a9c5fd
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC4A7 TRPM3 FRYL

8.13e-04174473f1fe1f4216748a9562dd03bd48c70b23c7ff4d1d
ToppCellCOVID-19-kidney-REN+Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

TRPM3 RAPGEF3 DAAM2

8.13e-041744738393f0b43c767839c1630bcb952d62b42efc788d
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DST ASPN DAAM2

8.27e-041754731799a7be623dc3bf53ba580a7c47d2619969d708
ToppCellNS-moderate-d_0-4-Epithelial-Ionocyte|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DST RAPGEF4 AR

8.27e-04175473a1e0a15c69211d6db2edeb101476f0f6e08b90c8
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_B-plasmablast-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

RAPGEF4 SYVN1 PKHD1L1

8.27e-041754733b5346fba617292de71963b6175e85a4f182fe30
ToppCellpdx-Tumor_cells-T2|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

SHANK2 KCNQ1 DSCAML1

8.41e-041764731e21f80cf0e695ffdd63e4a72cf1e3fa41b60341
ToppCellfacs-Heart-LA-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GOT1L1 SLC6A17 RASD2

8.55e-041774731b153fbfe1323dc589de4af73a52149ea5ce6763
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SHANK2 DSCAML1 HEPH

8.55e-041774738abdf1d970b2f15e17e185f3e612dd5065c88757
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PARP4 SHANK2 DSCAML1

8.55e-04177473da8802a6351d3e510822f82e2fde8a4314a2216e
ToppCellfacs-Heart-LA-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GOT1L1 SLC6A17 RASD2

8.55e-0417747332fecefba1a55e1f418c9a055236fa11175c692d
ToppCellControl-Epithelial_alveolar-AT_1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHANK2 TRPM3 DSCAML1

8.69e-04178473aa7d43c655df493f1330a5001efaa484e4a19f69
ToppCellCOVID-19-kidney-Epi_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

SHANK2 RAPGEF3 DSCAML1

8.69e-04178473544379f5a6145429762258d426b876bb36c112f5
ToppCelldroplet-Fat-SCAT-30m-Mesenchymal-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ASPN UGT8 DAAM2

8.69e-041784735cf12927f0756c4d8a289fe4308d736382e6212e
ToppCellAdult-Endothelial-endothelial_cell_of_lymph_vessel-D231|Adult / Lineage, Cell type, age group and donor

RAPGEF4 PKHD1L1 DSCAML1

8.69e-04178473c80ca7a2d3f976089a5e71d0cd9ba9a1c0bd2815
ToppCellControl-Epithelial_alveolar-AT_1-AT1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHANK2 TRPM3 DSCAML1

8.69e-041784731817bc520f3d23da8c0fa09bba50ae703a820cb1
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC4A7 PDE9A UGT8

8.69e-041784734df6218b20c2f076c22346d23260964cc0d73e65
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SHANK2 TRPM3 DSCAML1

8.83e-0417947304ce3673e46606f63d9c87bcba3a64c96817d812
ToppCell10x5'-lymph-node_spleen-Myeloid_Mac-Intestinal_macrophages|lymph-node_spleen / Manually curated celltypes from each tissue

DST P2RY13 DAAM2

8.97e-041804737be7d7a6906fff6dbdecd9cb013d855aba4eda2a
ToppCellCOVID-19-kidney-tDL|COVID-19 / Disease (COVID-19 only), tissue and cell type

SHANK2 TRPM3 DSCAML1

8.97e-04180473864c895b5eaedefae86f5829fa344f7b686fb59f
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SHANK2 TRPM3 RAPGEF3

8.97e-04180473023ec0b080c8a5cd0f36e83c6b17d4be3c01edb5
ToppCellChildren_(3_yrs)-Mesenchymal-myofibroblast_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

GOT1L1 ASPN DAAM2

8.97e-0418047301f2e5d96016823482f89ba503d007d4bd88eeac
ToppCellCOVID-19-kidney-PCT-S2|COVID-19 / Disease (COVID-19 only), tissue and cell type

SHANK2 TRPM3 DSCAML1

8.97e-04180473358923e4228035a3e90e2957392089219e90dcd7
ToppCellfacs-Heart-RA-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ASPN DAAM2 RASD2

9.12e-04181473429df38438d5a7ff490c9ede34b69e2970c7ded2
ToppCell10x5'-GI_small-bowel-Lymphocytic_B_plasma|GI_small-bowel / Manually curated celltypes from each tissue

AMPD1 RAPGEF3 PKHD1L1

9.12e-041814739b33f531c8ac776706ec7e2d47e95ba30b6ce13c
ToppCellfacs-Heart-RA-3m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ASPN DAAM2 RASD2

9.12e-04181473395cf5aa2d89b05328ab516b8c89401020b6d830
ToppCell10x5'-GI_small-bowel-Lymphocytic_B_plasma-Plasma_cells|GI_small-bowel / Manually curated celltypes from each tissue

AMPD1 RAPGEF3 PKHD1L1

9.12e-04181473a0549a8c2b5b30e91fae3052f398e48baa45d7ff
Diseasesphingomyelin 14:0 measurement

THADA TRPM3

2.41e-0417402EFO_0010390
Diseasecerebellum white matter volume change measurement, age at assessment

GOT1L1 SYVN1

3.35e-0420402EFO_0008007, EFO_0021498
Diseasemultiple system atrophy

USP31 PKHD1L1

1.35e-0340402EFO_1001050
Diseaseautistic disorder (is_implicated_in)

SHANK2 RAPGEF4

1.49e-0342402DOID:12849 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
GLPDLTFMHAKVLMF

AFTPH

906

Q6ULP2
MPTLSVFMDVPLAHK

GOT1L1

1

Q8NHS2
FLPHFGKMLENIFMP

AMPD1

471

P23109
LTKDPFIHEIATMIM

ARMCX5

321

Q6P1M9
KPFFSPSHIALKNMM

ASPN

16

Q9BXN1
QPLIFHMEMLKVESP

AIP

146

O00170
VSLFHTVIFPLMNPM

OR4N4C

271

A0A096LPK9
EFILMGFMDHPKLEI

OR9I1

11

Q8NGQ6
IMILEKHFPDILNMP

DAAM2

846

Q86T65
LCKPLHYLTIMSPRM

OR4F21

126

O95013
RKSPTLLEVSMPHFM

KCNQ1

466

P51787
MHEYLTLLQDMKPPL

DST

3401

Q03001
ICKPLHYMTIMSPRV

OR4K13

126

Q8NH42
VSLFHTVIFPLMNPM

OR4N4

271

Q8N0Y3
LIPMFETVTKLFPMV

PDE9A

521

O76083
IPSPSSLFKHIVPMM

FRYL

911

O94915
FHLLLMTPKPMIRAF

NOL6

456

Q9H6R4
APMLAPEHTLMSFRK

GDPD5

236

Q8WTR4
VFPFLKMVLTEMPHH

GCN1

981

Q92616
LLIKSHMVSVDFPEM

AR

881

P10275
ICKPLHYLTIMSPRM

OR4F15

126

Q8NGB8
MTEFYRLIPHKGTMP

PARP4

321

Q9UKK3
IMTLMLPFKILSDSH

P2RY13

91

Q9BPV8
ALEIFFLLPECPMMH

HERC5

486

Q9UII4
VMLLDFIQHIMKSSP

ATR

66

Q13535
MFLTVKIPAMITSHP

DSCAML1

781

Q8TD84
YTPMEVHLTPEMIKL

CUL4A

536

Q13619
AKIIIVPPIMFESHM

UGT8

21

Q16880
RAENSKLLPMMTFPH

KIF28P

371

B7ZC32
KLLPMMTFPHLLNLS

KIF28P

376

B7ZC32
LCKPLHYLTIMSPRM

OR4F3;

126

Q6IEY1
FFPLHPMMITNAERL

MRPS16

96

Q9Y3D3
MTIMIKVHTFPLFAI

SYVN1

231

Q86TM6
IPFMPLLIKDMTFTH

RAPGEF4

921

Q8WZA2
ILFIKTMFHPSEKIP

THADA

256

Q6YHU6
LSVFMTSVLKFIPMP

SLC4A7

1021

Q9Y6M7
MLFPHTFVMAIMQPD

HEPH

676

Q9BQS7
LTMLDPHLKTPMYFF

OR6C68

46

A6NDL8
PHTISKILYPVMMFS

MRGPRX1

91

Q96LB2
DLMKEFPLLSMFNIH

ST7

321

Q9NRC1
FLAPPMLKFTRSLSM

SHANK2

866

Q9UPX8
VIPFMPLLLKDMTFI

RAPGEF3

811

O95398
VMVKTLPLHSFPTML

UBN2

691

Q6ZU65
PPLIIFSHMTMIFQH

TRPM3

1171

Q9HCF6
LFSMAKLPHEMSPAL

RASD2

186

Q96D21
IFPMIYMPAAISHKI

PKHD1L1

3511

Q86WI1
ILHMFTPKLDKMLDP

SLC6A17

281

Q9H1V8
MVKFPLTGLDMTPHV

USP31

661

Q70CQ4
AVQILDSFPMMPIKH

VWA8

321

A3KMH1
FLSVAMHQIMPKEIL

XXYLT1

206

Q8NBI6
SLMVQMPKETYLVHP

LRIG2

936

O94898