Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	GPCR_2_secretin-like_CS	ADGRA2 ADGRG4 CRHR2	5.20e-05	34	40	3	IPR017983
Domain	G_PROTEIN_RECEP_F2_1	ADGRA2 ADGRG4 CRHR2	8.51e-05	40	40	3	PS00649
Domain	G_PROTEIN_RECEP_F2_3	ADGRA2 ADGRG4 CRHR2	8.51e-05	40	40	3	PS50227
Domain	GPCR_2_extracellular_dom	ADGRA2 ADGRG4 CRHR2	8.51e-05	40	40	3	IPR001879
Domain	G_PROTEIN_RECEP_F2_2	ADGRA2 ADGRG4 CRHR2	1.66e-04	50	40	3	PS00650
Domain	7tm_2	ADGRA2 ADGRG4 CRHR2	1.66e-04	50	40	3	PF00002
Domain	GPCR_2-like	ADGRA2 ADGRG4 CRHR2	2.86e-04	60	40	3	IPR017981
Domain	GPCR_2_secretin-like	ADGRA2 ADGRG4 CRHR2	2.86e-04	60	40	3	IPR000832
Domain	G_PROTEIN_RECEP_F2_4	ADGRA2 ADGRG4 CRHR2	3.00e-04	61	40	3	PS50261
Domain	HRM	ADGRA2 CRHR2	1.63e-03	28	40	2	PF02793
Domain	GPS	ADGRA2 ADGRG4	2.40e-03	34	40	2	SM00303
Domain	GPS	ADGRA2 ADGRG4	2.54e-03	35	40	2	PF01825
Domain	GPS	ADGRA2 ADGRG4	2.69e-03	36	40	2	PS50221
Domain	GPS	ADGRA2 ADGRG4	2.84e-03	37	40	2	IPR000203
Domain	Znf_C2H2-like	ZNF215 ZNF782 RNF114 ZNF37A ZNF804A CASZ1	6.54e-03	796	40	6	IPR015880
Domain	Znf_C2H2	ZNF215 ZNF782 RNF114 ZNF37A ZNF804A CASZ1	6.90e-03	805	40	6	IPR007087
Domain	ZnF_C2H2	ZNF215 ZNF782 RNF114 ZNF37A ZNF804A CASZ1	7.03e-03	808	40	6	SM00355
Pubmed	PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth.	PBRM1 TP53	1.29e-06	2	40	2	31863007
Pubmed	PBRM1 (BAF180) protein is functionally regulated by p53-induced protein degradation in renal cell carcinomas.	PBRM1 TP53	1.29e-06	2	40	2	26178300
Pubmed	Potential role and chronology of abnormal expression of the Deleted in Colon Cancer (DCC) and the p53 proteins in the development of gastric cancer.	DCC TP53	1.29e-06	2	40	2	11518545
Pubmed	Deleted in colorectal carcinoma suppresses metastasis in p53-deficient mammary tumours.	DCC TP53	1.29e-06	2	40	2	22358843
Pubmed	FUCA1 is induced by wild-type p53 and expressed at different levels in thyroid cancers depending on p53 status.	FUT8 TP53	3.87e-06	3	40	2	28440416
Pubmed	Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence.	PBRM1 TP53	3.87e-06	3	40	2	20660729
Pubmed	The UbL-UBA Ubiquilin4 protein functions as a tumor suppressor in gastric cancer by p53-dependent and p53-independent regulation of p21.	RNF114 TP53	7.73e-06	4	40	2	29899380
Pubmed	Analysis of mutations in TP53, APC, K-ras, and DCC genes in the non-dysplastic mucosa of patients with inflammatory bowel disease.	DCC TP53	7.73e-06	4	40	2	19543899
Pubmed	beta-arrestin 2 oligomerization controls the Mdm2-dependent inhibition of p53.	FLNA TP53	1.29e-05	5	40	2	17984062
Pubmed	MUC5AC interactions with integrin β4 enhances the migration of lung cancer cells through FAK signaling.	MUC5AC TP53	1.29e-05	5	40	2	26751774
Pubmed	XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313.	RNF114 TP53	1.93e-05	6	40	2	25313037
Pubmed	Casz1 is required for cardiomyocyte G1-to-S phase progression during mammalian cardiac development.	FLNA CASZ1	4.62e-05	9	40	2	25953344
Pubmed	Network-Based Combinatorial CRISPR-Cas9 Screens Identify Synergistic Modules in Human Cells.	DCC IL23R TP53	5.33e-05	63	40	3	30762338
Pubmed	LncRNA SAMD12-AS1 promotes cell proliferation and inhibits apoptosis by interacting with NPM1.	FLNA TP53	8.45e-05	12	40	2	31406141
Pubmed	Genotype phenotype correlations in Israeli colorectal cancer patients.	DCC TP53	9.98e-05	13	40	2	15523694
Pubmed	Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.	GCK TUBGCP3	1.16e-04	14	40	2	20858683
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	FLNA PBRM1 MYO7B TP53	1.51e-04	234	40	4	36243803
Pubmed	Histone H3.3 maintains genome integrity during mammalian development.	ZNF804A TP53	1.53e-04	16	40	2	26159997
Pubmed	A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.	RNF114 IL23R	2.18e-04	19	40	2	20953190
Pubmed	PEG3 binds to H19-ICR as a transcriptional repressor.	PRDM11 TP53	2.94e-04	22	40	2	27824289
Pubmed	Essential role of the zinc finger transcription factor Casz1 for mammalian cardiac morphogenesis and development.	DCC CASZ1	3.21e-04	23	40	2	25190801
Pubmed	Induction of Gastric Cancer by Successive Oncogenic Activation in the Corpus.	MUC5AC TP53	3.80e-04	25	40	2	34391772
Pubmed	Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.	DOK6 ZNF215	4.78e-04	28	40	2	24483146
Pubmed	The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.	ADGRA2 ADGRG4	5.13e-04	29	40	2	15203201
Pubmed	International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.	ADGRA2 ADGRG4	6.66e-04	33	40	2	25713288
Pubmed	Lynch Syndrome	DCC TP53	6.66e-04	33	40	2	20301390
Pubmed	Reduced lifespan of mice lacking catalase correlates with altered lipid metabolism without oxidative damage or premature aging.	GCK TP53	7.49e-04	35	40	2	30818059
Pubmed	HSP90 Shapes the Consequences of Human Genetic Variation.	SMCR8 TP53	7.93e-04	36	40	2	28215707
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	FLNA PBRM1 DCC PGAP1	7.93e-04	363	40	4	14691545
Pubmed	Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport.	MAN2B2 FUT8	8.37e-04	37	40	2	2542563
Pubmed	Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1.	MAN2B2 FUT8	8.37e-04	37	40	2	2541446
Pubmed	Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis.	MAN2B2 FUT8	8.83e-04	38	40	2	2829950
Pubmed	Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1.	MAN2B2 FUT8	8.83e-04	38	40	2	2187500
Pubmed	Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes.	PBRM1 DCC PGAP1	9.11e-04	165	40	3	16107646
Pubmed	Genetic composition of the recombinant congenic strains.	DCC TP53	1.03e-03	41	40	2	8903730
Pubmed	Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2.	FLNA DCAF6	1.03e-03	41	40	2	18157088
GeneFamily	WD repeat domain containing	DCAF6 FBXW12 WDR20	6.11e-03	262	26	3	362
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF215 ZNF782 ZNF37A CASZ1	1.84e-02	718	26	4	28
Coexpression	GSE37534_UNTREATED_VS_ROSIGLITAZONE_TREATED_CD4_TCELL_PPARG1_AND_FOXP3_TRASDUCED_UP	FLNA ZNF215 SPACA9 PRDM11 FBXW12	1.07e-05	197	39	5	M8983
Coexpression	GSE17301_IFNA2_VS_IFNA2_AND_ACD3_ACD28_STIM_CD8_TCELL_DN	DEFA6 ZNF215 STK39 GCK CENPI	1.12e-05	199	39	5	M8044
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOK6 DCC UPK1A RYR3	1.58e-05	169	40	4	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	GPR146 SPACA9 ZNF782 MUC5AC	1.69e-05	172	40	4	d65ffff3e341af34a043a0d802d7ba4b69de36e9
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-B_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR146 SPACA9 MAN2B2 UPK1A	1.73e-05	173	40	4	0a0cd40bb5f61431fe34758626c8a63ec610a8a5
ToppCell	5'-Adult-LymphNode-Hematopoietic-Plasma_cells\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ZNF215 DCC FUT8 ZNF804A	1.81e-05	175	40	4	6a093c74a6f3daeff07759d6eec542fc5c709149
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-Plasma_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DEFA6 ZNF215 DCC FUT8	1.94e-05	178	40	4	f815bc76f98aaea2d9058173b02b6f36e45283ce
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-Plasma_Cell-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DEFA6 ZNF215 DCC FUT8	1.94e-05	178	40	4	a0334764e865fea652c54b94bbc3b173f7cbc9fc
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-Plasma_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF215 DCC FUT8 ZNF804A	2.07e-05	181	40	4	6cdee2f56bc633b387b4dbbd78c624edbd712c24
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-Plasma_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF215 DCC FUT8 ZNF804A	2.07e-05	181	40	4	b75b8b025257bccfe661fd0f92ab284b2a9c12ee
ToppCell	10x5'v1-week_14-16-Hematopoietic-MK-early_MK\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	DOK6 FUT8 DCBLD2 RYR3	2.77e-05	195	40	4	9b4f217325afb2efb9c65f298ac87649cb1e1af9
ToppCell	Control_saline-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|Control_saline / Treatment groups by lineage, cell group, cell type	PTPN5 LYPD6 DCC RYR3	2.94e-05	198	40	4	0c4d2c68a42f8a9e964e2dd28092fe75f5216834
Drug	NSC406942	PTPN5 GCK PBRM1 MAN2B2 PGAP1 RYR3 SYNGR2 TUBGCP3	5.23e-06	565	40	8	CID000001115
Disease	resting heart rate, chronic obstructive pulmonary disease	FUT8 CASZ1 WDR20	7.81e-06	30	38	3	EFO_0000341, EFO_0004351
Disease	Thymoma	PBRM1 TP53	1.61e-05	5	38	2	C0040100
Disease	Thymic Carcinoma	PBRM1 TP53	3.38e-05	7	38	2	C0205969
Disease	Psoriasis	RNF114 IL23R TP53	5.50e-05	57	38	3	C0033860
Disease	Pustulosis of Palms and Soles	RNF114 IL23R TP53	5.50e-05	57	38	3	C0030246
Disease	Intrahepatic Cholangiocarcinoma	PBRM1 TP53	4.38e-04	24	38	2	C0345905
Disease	Sjogren's syndrome (is_marker_for)	MUC5AC IL23R	4.38e-04	24	38	2	DOID:12894 (is_marker_for)
Disease	Extrahepatic Cholangiocarcinoma	PBRM1 TP53	4.38e-04	24	38	2	C3805278
Disease	Cholangiocarcinoma	PBRM1 TP53	5.15e-04	26	38	2	C0206698
Disease	Colorectal cancer	DCC TP53	5.55e-04	27	38	2	cv:C0346629
Disease	COLORECTAL CANCER	DCC TP53	5.55e-04	27	38	2	114500
Disease	Neoplasm of the large intestine	DCC TP53	5.55e-04	27	38	2	cv:C0009404
Disease	Papillary Renal Cell Carcinoma	PBRM1 ZNF804A TP53	6.02e-04	128	38	3	C1306837
Disease	Renal Cell Carcinoma	PBRM1 ZNF804A TP53	6.02e-04	128	38	3	C0007134
Disease	Sarcomatoid Renal Cell Carcinoma	PBRM1 ZNF804A TP53	6.02e-04	128	38	3	C1266043
Disease	Chromophobe Renal Cell Carcinoma	PBRM1 ZNF804A TP53	6.02e-04	128	38	3	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	PBRM1 ZNF804A TP53	6.02e-04	128	38	3	C1266044
Disease	Epileptic encephalopathy	FLNA RYR3	6.87e-04	30	38	2	C0543888
Disease	Schizophrenia	PTPN5 PBRM1 DCC FUT8 ZNF804A TP53	8.60e-04	883	38	6	C0036341
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	PBRM1 ZNF804A TP53	9.17e-04	148	38	3	C0279702
Disease	coenzyme Q10 measurement	DCC FUT8	9.90e-04	36	38	2	EFO_0007836
Disease	Graves' disease (is_implicated_in)	IL23R TP53	1.16e-03	39	38	2	DOID:12361 (is_implicated_in)
Disease	Neoplasm of uncertain or unknown behavior of breast	PBRM1 TP53	1.28e-03	41	38	2	C0496956
Disease	Breast adenocarcinoma	PBRM1 TP53	1.28e-03	41	38	2	C0858252

Protein segments in the cluster

Peptide	Gene	Start	Entry
MIVNSTYVTHSVSYG	ADGRG4	1396	Q8IZF6
YQMVCQAVGITLHYS	ADGRA2	831	Q96PE1
YHCMQVGCNKVYTST	CASZ1	551	Q86V15
QFTCHYGTTYEIMTV	DCAF6	136	Q58WW2
TCEQYQFVHHVMSLY	PTPN5	541	P54829
TVATMISCYYEDHQC	GCK	206	P35557
GMYTCVVTYKNENIS	DCC	306	P43146
TYSQDCSFKNSMYHV	PBRM1	946	Q86U86
CYVLTTSENSVHVYM	FBXW12	391	Q6X9E4
GCYLHTAIVMTYSTE	CRHR2	206	Q13324
HQMQYYITFEVLECS	TUBGCP3	716	Q96CW5
KSMTYHYHVSTCQPT	MUC5AC	706	P98088
GSDCTTIHYNYMCNS	TP53	226	P04637
VYHMMCTQSYSVDSN	OSGIN2	356	Q9Y236
TEYSYGTCTVMGINH	DEFA6	81	Q01524
IYGECTMQITHENIY	DOK6	151	Q6PKX4
TYRCSYQPTMEGVHT	FLNA	441	P21333
VTCVIYEYSGNMTCT	IL23R	131	Q5VWK5
IFTHIMDQYSYCTPS	MAN2B2	206	Q9Y2E5
YCYTQHTMEVTGNSI	LYPD6	76	Q86Y78
TTGSTMVEHNYYVSA	DCBLD2	366	Q96PD2
TYMASVYNTRHVCGF	GPR146	136	Q96CH1
TYQEFNHYLTSMVGC	CENPI	636	Q92674
IGQVQSYMEHYCNSS	SPACA9	46	Q96E40
YAAVCNPLHYTTTMT	OR5B17	121	Q8NGF7
HVVYCFMIAYGTQRT	FUT8	226	Q9BYC5
YQDDAYSQCATTMTH	PRDM11	371	Q9NQV5
YTHVYCQSTMLDTNS	PGAP1	381	Q75T13
SGNMYLYNVEHTCGT	WDR20	171	Q8TBZ3
STYYLHVQSMLTQLC	SMCR8	841	Q8TEV9
VMLENYSHLVSVGYC	ZNF37A	36	P17032
HVATCSKYQNYIMEG	RNF114	106	Q9Y508
QMQEILSHTTTQCYY	RYR3	1316	Q15413
EGYSNAHESKQMYCV	SYNGR2	46	O43760
CITSYTHRDYMVSNP	UPK1A	111	O00322
KSHTTMNSYECYQCG	ZNF215	371	Q9UL58
VMLENYSHLVSVGYC	ZNF782	36	Q6ZMW2
QAMSQCSHPNVVTYY	STK39	111	Q9UEW8
MECYYIVISSTHLSN	ZNF804A	1	Q7Z570
SEYHYLTMGNCTSCE	MYO7B	276	Q6PIF6