Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	SCN4A SCN5A SCN8A	1.48e-05	26	37	3	GO:0005248
GeneOntologyMolecularFunction	sodium channel activity	SCN4A SCN5A SCN8A	1.22e-04	52	37	3	GO:0005272
GeneOntologyMolecularFunction	cytoskeletal protein binding	CCDC88C LASP1 HOOK3 NRAP NEB OFD1 VBP1 SCN5A	7.59e-04	1099	37	8	GO:0008092
GeneOntologyMolecularFunction	dynein light intermediate chain binding	CCDC88C HOOK3	1.23e-03	28	37	2	GO:0051959
GeneOntologyBiologicalProcess	cardiac muscle thin filament assembly	NRAP NEB	8.38e-06	3	35	2	GO:0071691
GeneOntologyBiologicalProcess	membrane depolarization during action potential	SCN4A SCN5A SCN8A	3.08e-05	36	35	3	GO:0086010
GeneOntologyBiologicalProcess	actin-mediated cell contraction	CCDC88C SCN4A SCN5A SCN8A	6.19e-05	127	35	4	GO:0070252
GeneOntologyBiologicalProcess	actin filament-based movement	CCDC88C SCN4A SCN5A SCN8A	1.27e-04	153	35	4	GO:0030048
GeneOntologyBiologicalProcess	membraneless organelle assembly	EFL1 NRAP NEB OFD1 SMC1A CHMP5	1.33e-04	475	35	6	GO:0140694
GeneOntologyBiologicalProcess	cardiac muscle cell action potential involved in contraction	SCN4A SCN5A SCN8A	1.58e-04	62	35	3	GO:0086002
GeneOntologyBiologicalProcess	neuronal action potential	SCN4A SCN5A SCN8A	1.66e-04	63	35	3	GO:0019228
GeneOntologyBiologicalProcess	cytoplasmic microtubule organization	CCDC88C HOOK3 IFT172	1.90e-04	66	35	3	GO:0031122
GeneOntologyBiologicalProcess	meiotic sister chromatid cohesion	SMC1A BUB1B	2.90e-04	15	35	2	GO:0051177
GeneOntologyBiologicalProcess	cardiac muscle cell action potential	SCN4A SCN5A SCN8A	4.30e-04	87	35	3	GO:0086001
GeneOntologyBiologicalProcess	mitotic sister chromatid segregation	OFD1 SMC1A CHMP5 BUB1B	4.42e-04	212	35	4	GO:0000070
GeneOntologyBiologicalProcess	mitotic spindle assembly	OFD1 SMC1A CHMP5	5.07e-04	92	35	3	GO:0090307
GeneOntologyBiologicalProcess	organelle assembly	EFL1 NRAP NEB OFD1 IFT172 SDC4 SMC1A CHMP5	5.19e-04	1138	35	8	GO:0070925
GeneOntologyBiologicalProcess	cardiac muscle cell contraction	SCN4A SCN5A SCN8A	5.23e-04	93	35	3	GO:0086003
GeneOntologyBiologicalProcess	cardiac myofibril assembly	NRAP NEB	5.76e-04	21	35	2	GO:0055003
GeneOntologyBiologicalProcess	actin filament-based process	CCDC88C NRAP NEB SDC4 SCN4A SCN5A SCN8A	7.33e-04	912	35	7	GO:0030029
GeneOntologyBiologicalProcess	sister chromatid segregation	OFD1 SMC1A CHMP5 BUB1B	8.71e-04	254	35	4	GO:0000819
GeneOntologyBiologicalProcess	transmission of nerve impulse	SCN4A SCN5A SCN8A	8.99e-04	112	35	3	GO:0019226
GeneOntologyCellularComponent	voltage-gated sodium channel complex	SCN4A SCN5A SCN8A	2.88e-06	17	35	3	GO:0001518
GeneOntologyCellularComponent	sodium channel complex	SCN4A SCN5A SCN8A	1.52e-05	29	35	3	GO:0034706
GeneOntologyCellularComponent	myofibril	NRAP NEB SDC4 SCN5A SCN8A	8.63e-05	273	35	5	GO:0030016
GeneOntologyCellularComponent	supramolecular fiber	TPT1 HOOK3 NRAP NEB FLACC1 SDC4 CHMP5 SCN5A SCN8A	1.04e-04	1179	35	9	GO:0099512
GeneOntologyCellularComponent	supramolecular polymer	TPT1 HOOK3 NRAP NEB FLACC1 SDC4 CHMP5 SCN5A SCN8A	1.10e-04	1187	35	9	GO:0099081
GeneOntologyCellularComponent	contractile muscle fiber	NRAP NEB SDC4 SCN5A SCN8A	1.15e-04	290	35	5	GO:0043292
GeneOntologyCellularComponent	Z disc	NRAP NEB SCN5A SCN8A	1.15e-04	151	35	4	GO:0030018
GeneOntologyCellularComponent	I band	NRAP NEB SCN5A SCN8A	1.66e-04	166	35	4	GO:0031674
GeneOntologyCellularComponent	kinetochore	CBX5 SMC1A CHMP5 BUB1B	2.31e-04	181	35	4	GO:0000776
GeneOntologyCellularComponent	condensed chromosome, centromeric region	CBX5 SMC1A CHMP5 BUB1B	2.95e-04	193	35	4	GO:0000779
GeneOntologyCellularComponent	sarcomere	NRAP NEB SCN5A SCN8A	7.70e-04	249	35	4	GO:0030017
GeneOntologyCellularComponent	chromosome, centromeric region	CBX5 SMC1A CHMP5 BUB1B	1.13e-03	276	35	4	GO:0000775
GeneOntologyCellularComponent	condensed chromosome	CBX5 SMC1A CHMP5 BUB1B	1.67e-03	307	35	4	GO:0000793
HumanPheno	Apnea	NEB OFD1 SMC1A SCN4A SCN5A BUB1B SCN8A	2.68e-06	372	11	7	HP:0002104
HumanPheno	Abnormal lung development	SLC25A24 NEB OFD1 IFT172 SCN4A BUB1B	4.29e-06	244	11	6	HP:4000059
HumanPheno	Hydrocephalus	SLC25A24 CCDC88C OFD1 IFT172 SMC1A SCN4A BUB1B	6.18e-06	421	11	7	HP:0000238
HumanPheno	Abnormal neurological laboratory findings	SLC25A24 CCDC88C NEB OFD1 IFT172 SMC1A SCN4A SCN5A BUB1B	1.57e-05	1000	11	9	HP:0003129
HumanPheno	Downslanted palpebral fissures	SLC25A24 OFD1 IFT172 SMC1A SCN4A BUB1B SCN8A	1.88e-05	497	11	7	HP:0000494
HumanPheno	Ophthalmoparesis	CCDC88C NEB OFD1 IFT172 SMC1A SCN4A	3.47e-05	350	11	6	HP:0000597
HumanPheno	Abnormal cerebrospinal fluid morphology	SLC25A24 CCDC88C OFD1 IFT172 SMC1A SCN4A BUB1B	1.06e-04	646	11	7	HP:0002921
HumanPheno	Ophthalmoplegia	NEB OFD1 IFT172 SMC1A SCN4A	1.31e-04	265	11	5	HP:0000602
HumanPheno	Abnormal location of ears	SLC25A24 EFL1 NEB OFD1 IFT172 SMC1A SCN4A BUB1B	1.32e-04	945	11	8	HP:0000357
HumanPheno	Generalized hypotonia	SLC25A24 NEB OFD1 SMC1A SCN4A BUB1B SCN8A	1.36e-04	671	11	7	HP:0001290
HumanPheno	Second trimester onset	CCDC88C SCN4A SCN5A	1.47e-04	51	11	3	HP:0034198
HumanPheno	Abnormal thorax morphology	SLC25A24 EFL1 NEB OFD1 IFT172 SMC1A SCN4A SCN5A BUB1B	1.76e-04	1328	11	9	HP:0000765
HumanPheno	Apneic episodes in infancy	SCN4A SCN5A	1.89e-04	10	11	2	HP:0005949
HumanPheno	Abnormality of the philtrum	SLC25A24 NEB OFD1 IFT172 SMC1A SCN4A BUB1B	2.27e-04	726	11	7	HP:0000288
HumanPheno	Neonatal seizure	SMC1A SCN8A	2.31e-04	11	11	2	HP:0032807
HumanPheno	Slanting of the palpebral fissure	SLC25A24 OFD1 IFT172 SMC1A SCN4A BUB1B SCN8A	2.55e-04	739	11	7	HP:0200006
HumanPheno	Aplasia/Hypoplasia of the lungs	SLC25A24 NEB IFT172 SCN4A	2.60e-04	160	11	4	HP:0006703
HumanPheno	Abnormality of the amniotic fluid	SLC25A24 NEB OFD1 SCN4A BUB1B SCN8A	2.73e-04	504	11	6	HP:0001560
HumanPheno	Polyhydramnios	NEB OFD1 SCN4A BUB1B SCN8A	2.84e-04	312	11	5	HP:0001561
HumanPheno	High palate	SLC25A24 EFL1 NEB OFD1 IFT172 SMC1A SCN4A	4.04e-04	794	11	7	HP:0000218
HumanPheno	Abnormality of the joints of the lower limbs	CCDC88C EFL1 NEB OFD1 IFT172 SCN4A	4.29e-04	547	11	6	HP:0100239
HumanPheno	Tricuspid regurgitation	SLC25A24 SCN4A SCN5A	5.02e-04	77	11	3	HP:0005180
HumanPheno	Mortality/Aging	SLC25A24 EFL1 NEB SCN4A SCN5A SCN8A	5.03e-04	563	11	6	HP:0040006
HumanPheno	Age of death	SLC25A24 EFL1 NEB SCN4A SCN5A SCN8A	5.03e-04	563	11	6	HP:0011420
HumanPheno	Abnormal tricuspid valve physiology	SLC25A24 SCN4A SCN5A	5.62e-04	80	11	3	HP:0031651
HumanPheno	Fetal anomaly	NEB SMC1A SCN4A SCN5A BUB1B SCN8A	5.65e-04	575	11	6	HP:0034057
HumanPheno	Abnormality of prenatal development or birth	SLC25A24 NEB OFD1 SMC1A SCN4A SCN5A BUB1B SCN8A	5.94e-04	1159	11	8	HP:0001197
HumanPheno	Feeding difficulties	SLC25A24 NEB OFD1 IFT172 SMC1A SCN4A BUB1B SCN8A	6.29e-04	1168	11	8	HP:0011968
HumanPheno	Retrognathia	SLC25A24 OFD1 IFT172 SMC1A SCN4A	6.71e-04	375	11	5	HP:0000278
HumanPheno	Abnormal pattern of respiration	NEB OFD1 SMC1A SCN4A SCN5A BUB1B SCN8A	7.33e-04	872	11	7	HP:0002793
HumanPheno	Generalized hirsutism	SLC25A24 IFT172 SMC1A	7.69e-04	89	11	3	HP:0002230
HumanPheno	Abnormal palate morphology	SLC25A24 EFL1 NEB OFD1 IFT172 SMC1A SCN4A BUB1B	7.74e-04	1202	11	8	HP:0000174
HumanPheno	Abnormality of the palpebral fissures	SLC25A24 OFD1 IFT172 SMC1A SCN4A BUB1B SCN8A	7.77e-04	880	11	7	HP:0008050
HumanPheno	Weakness of long finger extensor muscles	NEB SCN4A	7.89e-04	20	11	2	HP:0009077
HumanPheno	Triangular mouth	SCN4A BUB1B	7.89e-04	20	11	2	HP:0000207
HumanPheno	Congenital onset	SLC25A24 CCDC88C OFD1 IFT172 SMC1A SCN4A SCN5A SCN8A	7.93e-04	1206	11	8	HP:0003577
HumanPheno	Hirsutism	SLC25A24 OFD1 IFT172 SMC1A	8.20e-04	216	11	4	HP:0001007
HumanPheno	Abnormal cardiac atrium morphology	SLC25A24 OFD1 IFT172 SMC1A SCN5A BUB1B	8.32e-04	617	11	6	HP:0005120
HumanPheno	Short neck	NEB IFT172 SMC1A SCN4A BUB1B	8.83e-04	398	11	5	HP:0000470
HumanPheno	Aplasia/Hypoplasia involving the nose	SLC25A24 OFD1 SMC1A SCN4A BUB1B	9.15e-04	401	11	5	HP:0009924
HumanPheno	Abnormality of the tubular bones	EFL1 NEB OFD1 IFT172 SMC1A SCN4A	9.48e-04	632	11	6	HP:0100713
HumanPheno	Abnormality of the long tubular bones	EFL1 NEB OFD1 IFT172 SMC1A SCN4A	9.48e-04	632	11	6	HP:0100714
HumanPheno	Pace of progression	SLC25A24 CCDC88C EFL1 NEB SCN4A SCN5A SCN8A	9.67e-04	911	11	7	HP:0003679
HumanPheno	Hypoplasia of penis	SLC25A24 NEB IFT172 SMC1A BUB1B	9.90e-04	408	11	5	HP:0008736
HumanPheno	Medial flaring of the eyebrow	SLC25A24 IFT172 SMC1A SCN4A	1.01e-03	228	11	4	HP:0010747
HumanPheno	Multicystic kidney dysplasia	OFD1 SMC1A BUB1B	1.02e-03	98	11	3	HP:0000003
HumanPheno	Reduced systolic function	SCN4A SCN5A	1.05e-03	23	11	2	HP:0006673
HumanPheno	Weakness of the intrinsic hand muscles	NEB SCN4A	1.14e-03	24	11	2	HP:0009005
HumanPheno	Abnormal number of teeth	SLC25A24 OFD1 IFT172 SMC1A SCN8A	1.14e-03	421	11	5	HP:0006483
HumanPheno	Hypertrichosis	SLC25A24 OFD1 IFT172 SMC1A SCN4A	1.19e-03	425	11	5	HP:0000998
HumanPheno	Intellectual disability, borderline	IFT172 SCN8A	1.24e-03	25	11	2	HP:0006889
HumanPheno	Abnormal tricuspid valve morphology	SLC25A24 SCN4A SCN5A	1.25e-03	105	11	3	HP:0031440
HumanPheno	Long philtrum	SLC25A24 NEB IFT172 SMC1A BUB1B	1.25e-03	429	11	5	HP:0000343
HumanPheno	Prenatal movement abnormality	NEB SMC1A SCN4A SCN8A	1.34e-03	246	11	4	HP:0001557
HumanPheno	Malignant hyperthermia	SCN4A SCN5A	1.34e-03	26	11	2	HP:0002047
HumanPheno	Functional motor deficit	CCDC88C NEB SMC1A SCN4A SCN5A	1.34e-03	436	11	5	HP:0004302
HumanPheno	Abnormal pinna morphology	SLC25A24 EFL1 NEB OFD1 IFT172 SMC1A SCN4A BUB1B	1.35e-03	1299	11	8	HP:0000377
HumanPheno	Death in infancy	SLC25A24 EFL1 NEB SCN4A	1.38e-03	248	11	4	HP:0001522
HumanPheno	Onset in infancy	SLC25A24 EFL1 NEB SCN4A	1.38e-03	248	11	4	HP:0003576
HumanPheno	Abnormality of the cervical spine	NEB IFT172 SMC1A SCN4A BUB1B	1.39e-03	439	11	5	HP:0003319
HumanPheno	Intellectual disability, profound	OFD1 BUB1B SCN8A	1.39e-03	109	11	3	HP:0002187
HumanPheno	Antenatal onset	CCDC88C SCN4A SCN5A BUB1B	1.46e-03	252	11	4	HP:0030674
HumanPheno	Abnormal upper lip morphology	SLC25A24 NEB OFD1 IFT172 SMC1A SCN4A BUB1B	1.53e-03	980	11	7	HP:0000177
HumanPheno	Abnormal tricuspid valve morphology	SLC25A24 SCN4A SCN5A	1.62e-03	115	11	3	HP:0001702
HumanPheno	Abnormality of the outer ear	SLC25A24 EFL1 NEB OFD1 IFT172 SMC1A SCN4A BUB1B	1.66e-03	1337	11	8	HP:0000356
HumanPheno	Neonatal death	SLC25A24 NEB SCN4A	1.66e-03	116	11	3	HP:0003811
HumanPheno	Limb myoclonus	SMC1A SCN8A	1.67e-03	29	11	2	HP:0045084
HumanPheno	Reduced vital capacity	NEB SCN4A	1.67e-03	29	11	2	HP:0002792
HumanPheno	Aplasia/hypoplasia affecting bones of the axial skeleton	SLC25A24 NEB OFD1 IFT172 SMC1A SCN4A BUB1B	1.82e-03	1008	11	7	HP:0009122
HumanPheno	Posteriorly rotated ears	SLC25A24 OFD1 IFT172 SMC1A BUB1B	1.89e-03	470	11	5	HP:0000358
HumanPheno	Abnormal sternum morphology	NEB IFT172 SMC1A SCN4A BUB1B	1.96e-03	474	11	5	HP:0000766
HumanPheno	Abnormality of lower limb joint	CCDC88C EFL1 NEB OFD1 IFT172 SMC1A SCN4A	2.04e-03	1027	11	7	HP:0100491
HumanPheno	Abnormality of the dentition	SLC25A24 EFL1 OFD1 IFT172 SMC1A SCN4A SCN8A	2.08e-03	1030	11	7	HP:0000164
HumanPheno	Micropenis	SLC25A24 NEB IFT172 BUB1B	2.11e-03	278	11	4	HP:0000054
HumanPheno	Abnormal finger morphology	SLC25A24 EFL1 NEB OFD1 IFT172 SMC1A SCN4A BUB1B	2.13e-03	1385	11	8	HP:0001167
Domain	NEBU	LASP1 NRAP NEB	2.41e-08	4	35	3	SM00227
Domain	NEBULIN	LASP1 NRAP NEB	2.41e-08	4	35	3	PS51216
Domain	Nebulin	LASP1 NRAP NEB	2.41e-08	4	35	3	PF00880
Domain	Nebulin_repeat	LASP1 NRAP NEB	2.41e-08	4	35	3	IPR000900
Domain	Nebulin	LASP1 NRAP NEB	2.41e-08	4	35	3	IPR013998
Domain	Na_channel_asu	SCN4A SCN5A SCN8A	7.17e-07	10	35	3	IPR001696
Domain	Na_trans_assoc	SCN4A SCN5A SCN8A	7.17e-07	10	35	3	IPR010526
Domain	Na_trans_assoc	SCN4A SCN5A SCN8A	7.17e-07	10	35	3	PF06512
Domain	HOOK	CCDC88C HOOK3	5.09e-05	6	35	2	PF05622
Domain	Hook-related_fam	CCDC88C HOOK3	5.09e-05	6	35	2	IPR008636
Domain	Na_trans_cytopl	SCN5A SCN8A	5.09e-05	6	35	2	PF11933
Domain	Na_trans_cytopl	SCN5A SCN8A	5.09e-05	6	35	2	IPR024583
Domain	Channel_four-helix_dom	SCN4A SCN5A SCN8A	1.65e-04	57	35	3	IPR027359
Domain	-	SCN4A SCN5A SCN8A	1.65e-04	57	35	3	1.20.120.350
Domain	IQ	SCN4A SCN5A SCN8A	4.65e-04	81	35	3	SM00015
Domain	IQ_motif_EF-hand-BS	SCN4A SCN5A SCN8A	6.33e-04	90	35	3	IPR000048
Domain	IQ	SCN4A SCN5A SCN8A	6.97e-04	93	35	3	PS50096
Domain	Ion_trans_dom	SCN4A SCN5A SCN8A	1.26e-03	114	35	3	IPR005821
Domain	Ion_trans	SCN4A SCN5A SCN8A	1.26e-03	114	35	3	PF00520
Domain	LIM	LASP1 NRAP	7.40e-03	69	35	2	PF00412
Domain	-	LASP1 NRAP	7.61e-03	70	35	2	2.10.110.10
Domain	LIM_DOMAIN_2	LASP1 NRAP	7.82e-03	71	35	2	PS50023
Domain	IQ	SCN4A SCN8A	7.82e-03	71	35	2	PF00612
Domain	Znf_LIM	LASP1 NRAP	7.82e-03	71	35	2	IPR001781
Domain	LIM_DOMAIN_1	LASP1 NRAP	7.82e-03	71	35	2	PS00478
Domain	LIM	LASP1 NRAP	7.82e-03	71	35	2	SM00132
Domain	SH3_9	LASP1 NEB	9.37e-03	78	35	2	PF14604
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SCN4A SCN5A SCN8A	1.44e-05	31	22	3	M877
Pathway	REACTOME_PHASE_0_RAPID_DEPOLARISATION	SCN4A SCN5A SCN8A	1.59e-05	32	22	3	M27455
Pathway	WP_REGULATION_OF_SISTER_CHROMATID_SEPARATION_AT_THE_METAPHASEANAPHASE_TRANSITION	SMC1A BUB1B	2.09e-04	14	22	2	M39772
Pathway	REACTOME_MUSCLE_CONTRACTION	NEB SCN4A SCN5A SCN8A	2.49e-04	203	22	4	M5485
Pathway	REACTOME_L1CAM_INTERACTIONS	SCN4A SCN5A SCN8A	8.43e-04	121	22	3	M872
Pathway	REACTOME_CARDIAC_CONDUCTION	SCN4A SCN5A SCN8A	1.04e-03	130	22	3	M27454
Pubmed	Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.	SCN4A SCN5A SCN8A	1.11e-08	5	37	3	17724025
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	HOOK3 NRAP NEB IPO7 TTC3 CBX5 SMC1A PEG3	4.41e-08	497	37	8	23414517
Pubmed	Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.	SCN4A SCN5A SCN8A	9.27e-08	9	37	3	15746173
Pubmed	International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.	SCN4A SCN5A SCN8A	9.27e-08	9	37	3	16382098
Pubmed	Mouse heart Na+ channels: primary structure and function of two isoforms and alternatively spliced variants.	SCN4A SCN5A	1.10e-06	2	37	2	11834499
Pubmed	Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif.	SCN4A SCN5A	1.10e-06	2	37	2	30944319
Pubmed	Modulation of skeletal and cardiac voltage-gated sodium channels by calmodulin.	SCN4A SCN5A	3.30e-06	3	37	2	15746172
Pubmed	Human voltage-gated sodium channel mutations that cause inherited neuronal and muscle channelopathies increase resurgent sodium currents.	SCN4A SCN5A	3.30e-06	3	37	2	20038812
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	TPT1 EFL1 LASP1 IPO7 CBX5 SMC1A VBP1 YLPM1	9.25e-06	1014	37	8	32416067
Pubmed	Early development of electrical excitability in the mouse enteric nervous system.	SCN5A SCN8A	1.10e-05	5	37	2	22875929
Pubmed	Dysregulation of NRAP degradation by KLHL41 contributes to pathophysiology in nemaline myopathy.	NRAP NEB	1.65e-05	6	37	2	30986853
Pubmed	Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes.	SCN5A SCN8A	2.30e-05	7	37	2	15272007
Pubmed	Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins.	SCN4A SCN5A	3.07e-05	8	37	2	9412493
Pubmed	Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals.	SCN5A SCN8A	3.95e-05	9	37	2	17884088
Pubmed	Protein interaction domain mapping of human kinetochore protein Blinkin reveals a consensus motif for binding of spindle assembly checkpoint proteins Bub1 and BubR1.	CBX5 BUB1B	4.93e-05	10	37	2	21199919
Pubmed	Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice.	SCN5A SCN8A	7.22e-05	12	37	2	30175250
Pubmed	Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.	SCN5A SCN8A	8.53e-05	13	37	2	15123669
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	LASP1 HOOK3 IPO7 OFD1 CBX5 SMC1A YLPM1	8.94e-05	1024	37	7	24711643
Pubmed	Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance.	LASP1 SMC1A CHMP5 YLPM1	9.69e-05	226	37	4	31452512
Pubmed	ERCC1-XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes.	SMC1A PEG3	9.94e-05	14	37	2	28368372
Pubmed	Inner centromere formation requires hMis14, a trident kinetochore protein that specifically recruits HP1 to human chromosomes.	CBX5 BUB1B	9.94e-05	14	37	2	20231385
Pubmed	Evolutionary plasticity of segmentation clock networks.	LASP1 E2F8	9.94e-05	14	37	2	21652651
Pubmed	Epigenetic displacement of HP1 from heterochromatin by HIV-1 Vpr causes premature sister chromatid separation.	CBX5 SMC1A	9.94e-05	14	37	2	21875947
Pubmed	KLHL40 deficiency destabilizes thin filament proteins and promotes nemaline myopathy.	NRAP NEB	1.31e-04	16	37	2	24960163
Pubmed	Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns.	CBX5 BUB1B	1.48e-04	17	37	2	14519686
Pubmed	Development of a deer mouse whole-genome radiation hybrid panel and comparative mapping of Mus chromosome 11 loci.	LASP1 SCN4A	1.67e-04	18	37	2	16416089
Pubmed	MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination.	NRAP NEB	2.07e-04	20	37	2	15967462
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	CCDC88C LASP1 HOOK3 OFD1 VBP1 BUB1B	2.60e-04	853	37	6	28718761
Pubmed	Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays.	SCN4A SCN5A	2.75e-04	23	37	2	16637659
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	SCN4A SCN5A SCN8A	4.39e-04	139	37	3	16985003
Pubmed	Alterations in the brain interactome of the intrinsically disordered N-terminal domain of the cellular prion protein (PrPC) in Alzheimer's disease.	TPT1 LASP1 IPO7 SULT4A1	4.65e-04	341	37	4	29791485
Pubmed	UBR-box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target.	SMC1A BUB1B	4.70e-04	30	37	2	32867711
Pubmed	A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.	IPO7 SMC1A VBP1	4.97e-04	145	37	3	23349634
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	TPT1 REXO2 LASP1 HOOK3 SDC4 VBP1 YLPM1	5.22e-04	1367	37	7	32687490
Pubmed	Joubert Syndrome	OFD1 IFT172	6.05e-04	34	37	2	20301500
Pubmed	Large-scale identification of mammalian proteins localized to nuclear sub-compartments.	CHMP5 YLPM1	7.56e-04	38	37	2	11555636
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	OFD1 SMC1A CHMP5 YLPM1	9.33e-04	411	37	4	35182466
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	TPT1 LASP1 IPO7 SMC1A E2F8 CHMP5	1.01e-03	1103	37	6	34189442
Pubmed	Aire's partners in the molecular control of immunological tolerance.	IPO7 SMC1A	1.06e-03	45	37	2	20085707
Pubmed	Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.	GRM3 SCN8A	1.06e-03	45	37	2	25979088
Interaction	SCN8A interactions	SCN4A SCN5A SCN8A	6.36e-06	20	37	3	int:SCN8A
Interaction	NBN interactions	TPT1 HOOK3 OFD1 SMC1A TIPARP	2.01e-05	183	37	5	int:NBN
Interaction	CCDC175 interactions	CCDC175 SMC1A	4.90e-05	6	37	2	int:CCDC175
Interaction	C15orf61 interactions	TIPARP BUB1B	4.90e-05	6	37	2	int:C15orf61
Interaction	FGF14 interactions	SMC1A SCN5A SCN8A	6.22e-05	42	37	3	int:FGF14
Interaction	DUSP16 interactions	HOOK3 OFD1 TTC3 IFT172 VBP1	6.91e-05	237	37	5	int:DUSP16
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN4A SCN5A SCN8A	2.48e-07	9	27	3	1203
GeneFamily	LIM domain containing	LASP1 NRAP	3.49e-03	59	27	2	1218
Coexpression	GSE10239_KLRG1INT_VS_KLRG1HIGH_EFF_CD8_TCELL_DN	SLC25A24 CCDC175 CBX5 DIPK1A CHMP5	8.58e-06	199	37	5	M3070
Coexpression	HALLMARK_E2F_TARGETS	IPO7 CBX5 SMC1A E2F8 BUB1B	8.79e-06	200	37	5	M5925
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal-skeletal_muscle_satellite_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTC3 SDC4 SMC1A PEG3 SCN5A	5.38e-07	193	37	5	1aa3ab528605dc7b2fec46e759c9d1ee93d59b11
ToppCell	saliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CCDC88C SAMD3 YLPM1 BUB1B	1.38e-05	177	37	4	9edfb50856f5e10672ab194ce0076d6a190e64de
ToppCell	droplet-Limb_Muscle-nan-21m-Mesenchymal-skeletal_muscle_satellite_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPT1 SDC4 PEG3 SCN5A	1.68e-05	186	37	4	1cbb1a1c4f0f6078e9c7b4e0dc93d6b6de7e57db
ToppCell	droplet-Limb_Muscle-nan-3m-Mesenchymal-skeletal_muscle_satellite_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPT1 SDC4 PEG3 SCN5A	1.86e-05	191	37	4	4fcbc214853e115608b3be7b35639247ae41c9dc
ToppCell	Entopeduncular-Neuronal\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	YPEL4 TTC3 SULT4A1 SCN8A	1.90e-05	192	37	4	4c35e5c28a40b439044797ba1f06cb7c36b2a8de
ToppCell	Thalamus-Neuronal\|Thalamus / BrainAtlas - Mouse McCarroll V32	YPEL4 TTC3 SULT4A1 PEG3	1.94e-05	193	37	4	712a4acd1167e43543950bc819ff11984e6f718d
ToppCell	Posterior_cortex-Neuronal\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	YPEL4 TTC3 SULT4A1 SCN8A	1.94e-05	193	37	4	b4989e3436e84dbec3789b46057e0f7a0ebf09d4
ToppCell	COVID_non-vent-Lymphocytic\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	SAMD3 ANKRD36C OFD1 TTC3	2.10e-05	197	37	4	c672915f8c8c1e948d251f6eaf9f84a5600c1193
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_cytokine_secreting_effector_T_cell\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CCDC88C SAMD3 ANKRD36C OFD1	2.14e-05	198	37	4	34c564ece9a2b94dcf646e3c95b5be9c5ecfaafe
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ANKRD36B TTC3 PEG3 SCN8A	2.14e-05	198	37	4	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	(10)_Ciliated-(2)_GFP_FOXI1\|(10)_Ciliated / shred by cell type by condition	ANKRD36B REXO2 TTC3 CHMP5	2.19e-05	199	37	4	61b1ed2db71b96157b92b7535d1955a4033098da
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SAMD3 CBX5 E2F8 BUB1B	2.19e-05	199	37	4	fba48342066aab41a8bcb20db40a6df0158e1cbe
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	SAMD3 CBX5 E2F8 BUB1B	2.19e-05	199	37	4	305a9ade5bbe8e981e7c641c9a5e0c9f8ef60470
ToppCell	COVID_non-vent-Lymphocytic-Proliferative_Lymphocyte-\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	CBX5 SMC1A E2F8 BUB1B	2.23e-05	200	37	4	04bf9e6a0fbd792b49eed63dabba5d6fafed8c07
ToppCell	LPS_IL1RA-Hematopoietic_Erythro-Megakary-Erythro-Mega-Erythroid\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	YPEL4 SULT4A1 FLACC1 E2F8	2.23e-05	200	37	4	fa1eaf008b54bdf7bbcdec8134460c5f64490de9
ToppCell	COVID_non-vent-Lymphocytic-Proliferative_Lymphocyte\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	CBX5 SMC1A E2F8 BUB1B	2.23e-05	200	37	4	f6b5320cdfe640a71e6e2df26f30d42e64b1c921
ToppCell	COVID-19-Lymphoid-Proliferating_CD8_T_cells\|Lymphoid / Condition, Lineage and Cell class	CBX5 SMC1A E2F8 BUB1B	2.23e-05	200	37	4	4556bb626ca1a00a6db13d2adb35acb8ba848f9c
ToppCell	LPS-antiTNF-Unknown\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NRAP E2F8 BUB1B	1.67e-04	129	37	3	739b263296c28554967362060b154f7a95e1341d
ToppCell	LPS-antiTNF-Unknown-Endothelial\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NRAP E2F8 BUB1B	1.70e-04	130	37	3	615c233c7c2600c1c2bc5cf5b1c501fc474564ef
ToppCell	LPS-antiTNF-Unknown-Endothelial-Pericyte_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NRAP E2F8 BUB1B	1.78e-04	132	37	3	02491930097b75aaeedab9e8200711b0dc610944
ToppCell	3'_v3-Lung-Lymphocytic_T_CD4-T_CD4/CD8\|Lung / Manually curated celltypes from each tissue	ANKRD36B CCDC88C ANKRD36C	2.65e-04	151	37	3	999c11d19b61d6b130ad5e623afa83cbdfe13cdd
ToppCell	COVID-19_Moderate-multiplets\|World / disease group, cell group and cell class	ANKRD36B SAMD3 ANKRD36C	2.91e-04	156	37	3	afdc025fa75e7926b1cc182c4a33654a2186abb1
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Tubular-6\|TCGA-Stomach / Sample_Type by Project: Shred V9	CCDC88C LASP1 E2F8	3.08e-04	159	37	3	655c0749c238bd68cb797adb83e25a23b8a3cc9d
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte-Chondrocyte_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IPO7 SDC4 PEG3	3.49e-04	166	37	3	37794a84601a2a949d579663d4a4bb8bc8fb5923
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Chondrocyte\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IPO7 SDC4 PEG3	3.49e-04	166	37	3	81c546c6d847e49e662b81e71992ca0f7a99e890
ToppCell	droplet-Pancreas-Endocrine-18m-Epithelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	YPEL4 TTC3 PEG3	3.49e-04	166	37	3	66026988509e39e41274fa0de738383219e8ff30
ToppCell	Control-Hematopoietic_Meg-Ery-Erythroid\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TPT1 YPEL4 FLACC1	3.68e-04	169	37	3	df1fc1477bbbb285063b9b122b1ac84c87fd7fa8
ToppCell	Control-Hematopoietic_Meg-Ery\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TPT1 YPEL4 FLACC1	3.68e-04	169	37	3	c2e2a7b89fe4a64d79efafdec037c4104f433061
ToppCell	Control-Hematopoietic_Meg-Ery-Erythroid-Erythroid\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TPT1 YPEL4 FLACC1	3.68e-04	169	37	3	92986559aa4a744e8b0487b0ae035cfb1fbf9890
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	E2F8 SCN4A BUB1B	3.81e-04	171	37	3	c2dbc439af28d4fabb24d57685b75b2e588819b0
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD4_rest-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CCDC88C TPT1 SAMD3	3.81e-04	171	37	3	e1fe07652c10c37191d1471ddaea500f74269e0c
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_cardiomyocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRAP NEB SCN5A	3.88e-04	172	37	3	bd468a7ea6ec832dcf6a816a1e0c03fa0f176dad
ToppCell	facs-Heart-Unknown-3m-Mesenchymal-atrial_myocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRAP NEB SCN5A	3.88e-04	172	37	3	ee8ce9e8c9a6d3ee2be113f77743958005f4b3f0
ToppCell	mild_COVID-19_(asymptomatic)-gd_T\|World / disease group, cell group and cell class (v2)	ANKRD36B SAMD3 OFD1	3.94e-04	173	37	3	b6615ff02f5017d7150b1e33b53f8c7a26081a0d
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c08-IL2RB\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SAMD3 OFD1 TIPARP	3.94e-04	173	37	3	5295ed31648abf8edff214cf67cd4769f20f9e6d
ToppCell	facs-Diaphragm-Limb_Muscle-24m-Mesenchymal-skeletal_muscle_satellite_cell\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPT1 SDC4 PEG3	4.01e-04	174	37	3	f230d23618a6487f2664efb2c677e0a4559e2bf4
ToppCell	LPS-IL1RA-Hematopoietic_Meg-Ery-Erythroid\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TPT1 YPEL4 FLACC1	4.08e-04	175	37	3	4d36da7399c62c170cb603957b35a35efb2c3fbe
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD4_rest\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CCDC88C TPT1 SAMD3	4.08e-04	175	37	3	8269721389a3ce98681460e6393f2cff816eaa25
ToppCell	LPS-IL1RA-Hematopoietic_Meg-Ery-Erythroid-Erythroid\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TPT1 YPEL4 FLACC1	4.08e-04	175	37	3	e4c9b3c6bde390a3892b112b673f93e118220eb9
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CCDC175 SAMD3 GRM3	4.15e-04	176	37	3	40993c41c1017b53039a337174fc56632b278609
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IPO7 CBX5 PEG3	4.15e-04	176	37	3	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	NS-moderate-d_0-4-Lymphoid-NKT-proliferating\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	E2F8 BUB1B SCN8A	4.22e-04	177	37	3	174c54acfe19e2bb31418d69e228032ba724cbb6
ToppCell	LPS-antiTNF-Hematopoietic_Meg-Ery-Erythroid\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TPT1 YPEL4 FLACC1	4.29e-04	178	37	3	eafacc8cd3e986d6ca309e05b6e241331a584fa5
ToppCell	LPS-antiTNF-Hematopoietic_Meg-Ery-Erythroid-Erythroid\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TPT1 YPEL4 FLACC1	4.29e-04	178	37	3	370749834a11d981e9ede26d5f63f0ecb551c015
ToppCell	LPS-antiTNF-Hematopoietic_Meg-Ery\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TPT1 YPEL4 FLACC1	4.29e-04	178	37	3	6a5c31e976852edc7d9e899da8e2a1bf23d36759
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-neurons_B-Branch_B2_(eMN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TMC2 SULT4A1 SCN8A	4.36e-04	179	37	3	228d12ed1c8dc92aefbcea4aaf7d108783c22be0
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-Granular_Neuron_CB_Gabra6\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	YPEL4 SAMD3 SULT4A1	4.43e-04	180	37	3	d76349ecef7c5878bf215e946f032264161eb61b
ToppCell	Adult-Immune-T_lymphocyte-D122\|Adult / Lineage, Cell type, age group and donor	CCDC88C SAMD3 DIPK1A	4.43e-04	180	37	3	06c371d0f0c5a7b234dd143e98800e19af95a8b5
ToppCell	facs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	YPEL4 SAMD3 SULT4A1	4.43e-04	180	37	3	3d54cc767e25d91ed2203d8a03e5bf5e15f21699
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC175 SCN5A BUB1B	4.50e-04	181	37	3	3fe648db1cb8326066d8bde3ca1287c5c9af19bd
ToppCell	droplet-Kidney-nan-3m-Hematologic-nan\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC88C EFL1 SAMD3	4.50e-04	181	37	3	58d7e76dfaa818aeaef7f129c4472bf5b6563218
ToppCell	3'-GW_trimst-2-SmallIntestine-Neuronal-neurons_A-Branch_A4_(IN)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TMC2 SULT4A1 SCN5A	4.50e-04	181	37	3	fb4df9a128761abe5c6310a30d7b2f7f2fdef46d
ToppCell	droplet-Kidney-nan-3m-Hematologic\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC88C EFL1 SAMD3	4.50e-04	181	37	3	5d76e99bf2b5b337041efd3cd33bebbb0637b64e
ToppCell	droplet-Kidney-nan-3m-Hematologic-leukocyte\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC88C EFL1 SAMD3	4.50e-04	181	37	3	970fc90e27236ee30190f1a02f418a378919c60b
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCDC175 SCN5A BUB1B	4.57e-04	182	37	3	39f9b3eb22293cc27c6e175702c77d1eeb24fdc9
ToppCell	5'-GW_trimst-2-LargeIntestine-Neuronal-neurons_B-Branch_B3_(IPAN)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TMC2 SULT4A1 SCN5A	4.65e-04	183	37	3	91764095f7ea4bc806ef6c7b841fc5e5e90faf5f
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4/8-lo-Cycling_T\|bone_marrow / Manually curated celltypes from each tissue	CBX5 E2F8 BUB1B	4.65e-04	183	37	3	a48a6313f2f144586951cece97ec31f6d72361df
ToppCell	343B-Lymphocytic-CD4_T-cell-Treg_cell_4\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	SLC25A24 CCDC88C IFT172	4.65e-04	183	37	3	3cbe0175d05fd39bc430de1ef471ff2c5b56460e
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-24m-Mesenchymal-skeletal_muscle_satellite_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPT1 SDC4 PEG3	4.65e-04	183	37	3	7534587fa35837c0aaca93c542f2eee493eba637
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-T_cell-T_cells_proliferating-T_cells_proliferating_L.1.1.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SMC1A E2F8 BUB1B	4.72e-04	184	37	3	eaef1dcde60ba14e2c7fd699d01c225487256d82
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-T_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SMC1A E2F8 BUB1B	4.72e-04	184	37	3	fa73738350654066d7f9ebf78359e20ee6cbdd98
ToppCell	3'-Distal_airway-Immune_Lymphocytic-Lymphocytic_T/NK-T_cell-T_cells_proliferating\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SMC1A E2F8 BUB1B	4.72e-04	184	37	3	bba0138c8f7e3645a688b9a4d12f6f2134ee2c08
ToppCell	URO-Lymphocyte-T_NK-T_NK_proliferative\|URO / Disease, Lineage and Cell Type	E2F8 SCN5A BUB1B	4.79e-04	185	37	3	0ae9c646679c69a553eda670aef0e0495feb0286
ToppCell	Brain_organoid-organoid_Kanton_Nature\|Brain_organoid / Sample Type, Dataset, Time_group, and Cell type.	ANKRD36B ANKRD36C OFD1	4.79e-04	185	37	3	857c7ca8493e91ef1d0078ddafd6082020f9b169
ToppCell	Substantia_nigra-Neuronal\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	TTC3 SULT4A1 PEG3	4.87e-04	186	37	3	3f889083fcffe516388e9b03a5e23af2010ced33
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-Granular_Neuron_CB_Gabra6\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SAMD3 SULT4A1 SCN8A	4.87e-04	186	37	3	d6c8ce2a32c218dcc63d861cc247152430ed3c8c
ToppCell	PCW_13-14-Hematologic_ErythroMegGranulo-Hem_ErythroMeg-erythro\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	REXO2 YPEL4 FLACC1	4.87e-04	186	37	3	34ed60e846fd83fab3e28dc9e278bcc4b092a9f0
ToppCell	Substantia_nigra-Neuronal-Inhibitory\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	TTC3 SULT4A1 PEG3	4.87e-04	186	37	3	9d3efe2a4feea2bc205a7e45b9b9f9ed9b3609ce
ToppCell	Cerebellum-Neuronal\|Cerebellum / BrainAtlas - Mouse McCarroll V32	YPEL4 TTC3 SULT4A1	4.95e-04	187	37	3	61b9d6eb131a674598aa8409d7fa909c8765442d
ToppCell	LA-03._Atrial_Cardiomyocyte\|World / Chamber and Cluster_Paper	NRAP NEB SCN5A	5.02e-04	188	37	3	6d249fe92d51a19da19ec14bb2262d394255d577
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	TTC3 SULT4A1 PEG3	5.02e-04	188	37	3	b73e8a40393c3f656e2fcfe395a761b1f985c254
ToppCell	COVID-19-lung-Plasma_cells_PRDM1/BLIMP_hi\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CCDC88C DIPK1A BUB1B	5.02e-04	188	37	3	567b08514d9d84cbb40f9b7a679eec304f023428
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK-T_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC88C SAMD3 DIPK1A	5.10e-04	189	37	3	b87d586a9570fa54f3e0c6bd4731c5badcaedae6
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CCDC88C SAMD3 TTC3	5.10e-04	189	37	3	d05e043d0874b8563b9f5514f6c884b35c603e3a
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC88C SAMD3 DIPK1A	5.10e-04	189	37	3	823d6debd09e440ddf36c54af24a5f20e222a21e
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK-T_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CCDC88C SAMD3 DIPK1A	5.10e-04	189	37	3	47c2b419b081d5bf75da5e3d9a0e05a70362dfe7
ToppCell	Int-URO-Lymphocyte-T_NK-T_NK_proliferative\|Int-URO / Disease, Lineage and Cell Type	CBX5 E2F8 SCN8A	5.18e-04	190	37	3	005967c540418b85311308072a07c684f4296aef
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK-Cycling_Natural_Killer_Cell_/_Natural_Killer_T_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SAMD3 E2F8 BUB1B	5.18e-04	190	37	3	185ae04c68f825cd346aa65072cc5da6a39dff4a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ANKRD36C E2F8 BUB1B	5.18e-04	190	37	3	31de1727822e9818652946dfb962daee77ffad68
ToppCell	3'_v3-Lung-Lymphocytic_T_CD8-Trm/em_CD8\|Lung / Manually curated celltypes from each tissue	CCDC88C SAMD3 OFD1	5.18e-04	190	37	3	74638e470ece8016465bbebc1756ffa6d605b25f
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1\|367C / Donor, Lineage, Cell class and subclass (all cells)	CCDC88C SAMD3 OFD1	5.18e-04	190	37	3	4240d52a465bc3f8016834b22a35c44ba2b0a9f4
ToppCell	Globus_pallidus-Neuronal\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	TTC3 SULT4A1 SCN8A	5.18e-04	190	37	3	416de85d8841dac883faa6f5339b2fb461a09e82
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Immune-Lymphocytic_T/NK-Cycling_Natural_Killer_Cell_/_Natural_Killer_T_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SAMD3 E2F8 BUB1B	5.18e-04	190	37	3	e38dc41f2e79e3bd51326581c6ebe51927edb549
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	YPEL4 TTC3 SULT4A1	5.26e-04	191	37	3	5d24022cec293bc8d9e978ae99a109e660bb8f83
ToppCell	3'_v3-bone_marrow-Lymphocytic_T_CD4/8-lo-Cycling_T\|bone_marrow / Manually curated celltypes from each tissue	CBX5 E2F8 BUB1B	5.26e-04	191	37	3	210a0f1a71df2508cbfc73d6868a2122338b9a1c
ToppCell	Entopeduncular-Neuronal-Inhibitory\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	YPEL4 TTC3 SULT4A1	5.26e-04	191	37	3	73dae4cdea86aec62393ad7303dc7375a6b3fc86
ToppCell	Fetal_29-31_weeks-Immune-T_lymphocyte-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CCDC88C SAMD3 DIPK1A	5.34e-04	192	37	3	92f141d5ac462f652f405efa73ac6ef751f40ea3
ToppCell	droplet-Lung-30m-Hematologic-myeloid-classical_monocyte_proliferating-classical_monocyte_proliferating_l12-14\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CBX5 SMC1A BUB1B	5.34e-04	192	37	3	52d0aa51e3b6ab3608a5f40bdde9f8134b3afd94
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell\|367C / Donor, Lineage, Cell class and subclass (all cells)	CCDC88C SAMD3 OFD1	5.34e-04	192	37	3	a0bd4a0d00246af4f6645e66a0dedfe36882cc60
ToppCell	facs-Thymus-Flowthrough-3m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CBX5 E2F8 BUB1B	5.34e-04	192	37	3	e8d47504b744040a762ec9b670a66cc060b2ae86
ToppCell	3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.3.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ANKRD36B ANKRD36C SDC4	5.42e-04	193	37	3	463274f394757fb2570ae885d58e1f9fa7e60c4a
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD8_cytotoxic\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CCDC88C TPT1 SAMD3	5.42e-04	193	37	3	8c3771a6b81cf48a46a14c5c869ffc96fd996fb7
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD8_cytotoxic-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CCDC88C TPT1 SAMD3	5.42e-04	193	37	3	ec5ae47719e0d6c989f8818d029ad5c3913eb85d
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTC3 SULT4A1 SCN8A	5.42e-04	193	37	3	5fb7808dd971c1cc64c2bd4f8f1de646fb2d77f4
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	YPEL4 SAMD3 SMC1A	5.51e-04	194	37	3	6be74e4ba631b0c46cef2c580553f4c1ed29579e
ToppCell	PBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CBX5 E2F8 BUB1B	5.51e-04	194	37	3	f39a471293ecc5c5967b00e772b8f48ebc9affbe
ToppCell	(3)_Chondrocytes-(33)_Chondro-prol/rest\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	E2F8 PEG3 BUB1B	5.51e-04	194	37	3	c093c5e161b97ad770bfbaad3023eba4537101b5
ToppCell	PBMC-Control-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CBX5 E2F8 BUB1B	5.51e-04	194	37	3	a75ecd0b0a928d4646602f7d16a645f6b3df3af5
ToppCell	Children_(3_yrs)-Immune-T_lymphocyte-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CCDC88C SAMD3 DIPK1A	5.51e-04	194	37	3	3d6f2d190dd50804afea299957cc44c2bb756134
ToppCell	ILEUM-inflamed-(6)_ILC1\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	SAMD3 OFD1 TIPARP	5.51e-04	194	37	3	dc9ca407ec3ebec1a3dea1213a2beef28c1dc043
Drug	Flecainide	SCN4A SCN5A	2.57e-06	2	37	2	DB01195
Drug	oxcarbazepine	REXO2 SCN4A SCN5A	1.56e-05	30	37	3	CID000034312
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN4A SCN5A SCN8A	1.82e-07	10	35	3	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN4A SCN5A SCN8A	1.82e-07	10	35	3	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN4A SCN5A SCN8A	3.34e-07	12	35	3	DOID:0060170 (implicated_via_orthology)
Disease	Congenital myopathy (disorder)	NEB SCN4A	8.95e-05	12	35	2	C0270960
Disease	epilepsy (implicated_via_orthology)	SCN4A SCN5A SCN8A	9.51e-04	163	35	3	DOID:1826 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
EKKEKMMYCKEKIYA	BUB1B	391	O60566
ELISEFMKKYKKMKE	CBX5	61	P45973
YYINMKAKKIMKGDQ	EFL1	271	Q7Z2Z2
AMKILDGKKLYKDYL	GRM3	421	Q14832
DIEKMYKSGYNTMEK	ANKRD36B	1136	Q8N2N9
KMEAKKKYEKELTMF	OFD1	231	O75665
KYKRKKEYMNRKMFG	TIPARP	506	Q7Z3E1
DIEKMYKSGYNTMEK	ANKRD36C	1561	Q5JPF3
VDAMKLGVKEMKKAY	CHMP5	106	Q9NZZ3
LYKYKMKEPTTKAEM	MAGEB4	121	O15481
KLEEMGKEYKYLKNM	FLACC1	206	Q96Q35
IKYKEEYEKTKGKAM	NRAP	581	Q86VF7
KMTLNMKNYKGYEKK	LASP1	36	Q14847
KEKLEEKIMDQYKFY	CCDC88C	1381	Q9P219
KKLDEQYQKYKFMEL	VBP1	51	P61758
EILLKKKIYKDQMEY	IPO7	441	O95373
EMKQMEERYKKYLEK	HOOK3	596	Q86VS8
EFQKMYGKEKMYECK	PEG3	616	Q9GZU2
KPADMKYGRKSYMVK	IFT172	56	Q9UG01
EDKKFLDKYMPQFMK	REXO2	146	Q9Y3B8
KYAEQIMMIKKKEYE	E2F8	201	A0AVK6
FVNKEKMLMKELSKY	CCDC175	526	P0C221
GYNDKYDLKMVDMRK	DIPK1A	301	Q5T7M9
LLLMYRMKKKDEGSY	SDC4	166	P31431
FMTEEQKKYYNAMKK	SCN4A	1311	P35499
EKMKHYTDEDMLKYM	SAMD3	386	Q8N6K7
FMTEEQKKYYNAMKK	SCN5A	1486	Q14524
MNEKFDLVYKQKMGK	SULT4A1	261	Q9BR01
YIKDYMKSIKGKLEE	TPT1	91	P13693
KMKIEEYIKKGKEDY	TTC3	1616	P53804
YKKRKGDMDELEKEM	SMC1A	326	Q14683
MTEEQKKYYNAMKKL	SCN8A	1481	Q9UQD0
KVKKKVMEYEYEAEM	YLPM1	1891	P49750
QKYKEGKYIIEMSHM	YPEL4	106	Q96NS1
GKGKQLYAYKMLMAK	TMC2	201	Q8TDI7
MKYLKDHEKKMKLAF	SLC25A24	81	Q6NUK1
MYKKDYEKNKGKMIG	NEB	596	P20929
DVMYKKDYEKSKGKM	NEB	841	P20929
VQYKKDYEKAKGKMV	NEB	1086	P20929