Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	TAP complex binding	HLA-H HLA-B	4.96e-05	9	24	2	GO:0062061
GeneOntologyMolecularFunction	CD8 receptor binding	HLA-H HLA-B	4.96e-05	9	24	2	GO:0042610
GeneOntologyMolecularFunction	TAP1 binding	HLA-H HLA-B	6.19e-05	10	24	2	GO:0046978
GeneOntologyMolecularFunction	TAP2 binding	HLA-H HLA-B	6.19e-05	10	24	2	GO:0046979
GeneOntologyMolecularFunction	TAP binding	HLA-H HLA-B	6.19e-05	10	24	2	GO:0046977
GeneOntologyMolecularFunction	beta-2-microglobulin binding	HLA-H HLA-B	9.07e-05	12	24	2	GO:0030881
GeneOntologyMolecularFunction	natural killer cell lectin-like receptor binding	HLA-H HLA-B	1.86e-04	17	24	2	GO:0046703
GeneOntologyMolecularFunction	T cell receptor binding	HLA-H HLA-B	2.60e-04	20	24	2	GO:0042608
GeneOntologyMolecularFunction	MHC class I protein binding	HLA-H HLA-B	6.72e-04	32	24	2	GO:0042288
GeneOntologyMolecularFunction	protein-folding chaperone binding	HLA-H HLA-B OGDH	9.19e-04	161	24	3	GO:0051087
GeneOntologyMolecularFunction	translation initiation factor binding	EIF3C EIF3CL	9.98e-04	39	24	2	GO:0031369
GeneOntologyMolecularFunction	14-3-3 protein binding	HLA-H HLA-B	1.16e-03	42	24	2	GO:0071889
GeneOntologyMolecularFunction	peptide antigen binding	HLA-H HLA-B	1.57e-03	49	24	2	GO:0042605
GeneOntologyMolecularFunction	translation initiation factor activity	EIF3C EIF3CL	1.70e-03	51	24	2	GO:0003743
GeneOntologyMolecularFunction	MHC protein binding	HLA-H HLA-B	2.20e-03	58	24	2	GO:0042287
GeneOntologyMolecularFunction	translation factor activity, RNA binding	EIF3C EIF3CL	4.65e-03	85	24	2	GO:0008135
GeneOntologyMolecularFunction	translation regulator activity, nucleic acid binding	EIF3C EIF3CL	7.94e-03	112	24	2	GO:0090079
GeneOntologyMolecularFunction	ribosome binding	EIF3C EIF3CL	9.07e-03	120	24	2	GO:0043022
GeneOntologyBiologicalProcess	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent	HLA-H HLA-B	3.62e-05	8	24	2	GO:0002485
GeneOntologyBiologicalProcess	formation of cytoplasmic translation initiation complex	EIF3C EIF3CL	1.35e-04	15	24	2	GO:0001732
GeneOntologyBiologicalProcess	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent	HLA-H HLA-B	1.54e-04	16	24	2	GO:0002486
GeneOntologyBiologicalProcess	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway	HLA-H HLA-B	1.75e-04	17	24	2	GO:0002484
GeneOntologyBiologicalProcess	antigen processing and presentation of endogenous peptide antigen via MHC class Ib	HLA-H HLA-B	1.75e-04	17	24	2	GO:0002476
GeneOntologyBiologicalProcess	antigen processing and presentation of exogenous peptide antigen via MHC class I	HLA-H HLA-B	1.96e-04	18	24	2	GO:0042590
GeneOntologyBiologicalProcess	antigen processing and presentation of peptide antigen via MHC class Ib	HLA-H HLA-B	1.96e-04	18	24	2	GO:0002428
GeneOntologyBiologicalProcess	antigen processing and presentation of endogenous peptide antigen via MHC class I	HLA-H HLA-B	3.23e-04	23	24	2	GO:0019885
GeneOntologyBiologicalProcess	antigen processing and presentation of endogenous peptide antigen	HLA-H HLA-B	3.83e-04	25	24	2	GO:0002483
GeneOntologyBiologicalProcess	antigen processing and presentation via MHC class Ib	HLA-H HLA-B	3.83e-04	25	24	2	GO:0002475
GeneOntologyBiologicalProcess	antigen processing and presentation of endogenous antigen	HLA-H HLA-B	6.30e-04	32	24	2	GO:0019883
GeneOntologyBiologicalProcess	antigen processing and presentation of peptide antigen via MHC class I	HLA-H HLA-B	1.03e-03	41	24	2	GO:0002474
GeneOntologyBiologicalProcess	positive regulation of T cell mediated cytotoxicity	HLA-H HLA-B	1.09e-03	42	24	2	GO:0001916
GeneOntologyCellularComponent	MHC class Ib protein complex	HLA-H HLA-B	2.87e-05	7	25	2	GO:0032398
GeneOntologyCellularComponent	eukaryotic translation initiation factor 3 complex, eIF3m	EIF3C EIF3CL	4.92e-05	9	25	2	GO:0071541
GeneOntologyCellularComponent	MHC class I protein complex	HLA-H HLA-B	6.14e-05	10	25	2	GO:0042612
GeneOntologyCellularComponent	MHC class I peptide loading complex	HLA-H HLA-B	1.24e-04	14	25	2	GO:0042824
GeneOntologyCellularComponent	eukaryotic translation initiation factor 3 complex	EIF3C EIF3CL	1.63e-04	16	25	2	GO:0005852
GeneOntologyCellularComponent	cis-Golgi network membrane	HLA-H HLA-B	1.85e-04	17	25	2	GO:0033106
GeneOntologyCellularComponent	eukaryotic 48S preinitiation complex	EIF3C EIF3CL	2.08e-04	18	25	2	GO:0033290
GeneOntologyCellularComponent	eukaryotic 43S preinitiation complex	EIF3C EIF3CL	2.32e-04	19	25	2	GO:0016282
GeneOntologyCellularComponent	translation preinitiation complex	EIF3C EIF3CL	2.57e-04	20	25	2	GO:0070993
GeneOntologyCellularComponent	Golgi medial cisterna	HLA-H HLA-B	3.42e-04	23	25	2	GO:0005797
GeneOntologyCellularComponent	MHC protein complex	HLA-H HLA-B	4.38e-04	26	25	2	GO:0042611
GeneOntologyCellularComponent	lumenal side of endoplasmic reticulum membrane	HLA-H HLA-B	7.97e-04	35	25	2	GO:0098553
GeneOntologyCellularComponent	endoplasmic reticulum exit site	HLA-H HLA-B	1.15e-03	42	25	2	GO:0070971
GeneOntologyCellularComponent	lumenal side of membrane	HLA-H HLA-B	1.50e-03	48	25	2	GO:0098576
GeneOntologyCellularComponent	ER to Golgi transport vesicle membrane	HLA-H HLA-B	2.65e-03	64	25	2	GO:0012507
GeneOntologyCellularComponent	phagocytic vesicle membrane	HLA-H HLA-B	4.40e-03	83	25	2	GO:0030670
GeneOntologyCellularComponent	cis-Golgi network	HLA-H HLA-B	4.61e-03	85	25	2	GO:0005801
MousePheno	abnormal hallux morphology	EIF3C EIF3CL	1.23e-05	5	16	2	MP:0009049
MousePheno	spinal cord inflammation	HLA-H HLA-B	3.43e-05	8	16	2	MP:0030987
MousePheno	head spot	EIF3C EIF3CL	5.50e-05	10	16	2	MP:0002939
MousePheno	decreased immature NK cell number	HLA-H HLA-B	1.11e-04	14	16	2	MP:0013666
MousePheno	decreased mature NK cell number	HLA-H HLA-B	1.86e-04	18	16	2	MP:0013672
MousePheno	abnormal immature NK cell number	HLA-H HLA-B	2.08e-04	19	16	2	MP:0013665
MousePheno	abnormal immature NK cell morphology	HLA-H HLA-B	2.08e-04	19	16	2	MP:0013699
MousePheno	cystolithiasis	HLA-H HLA-B	2.80e-04	22	16	2	MP:0011625
MousePheno	decreased NK cell number	HLA-H NUB1 HLA-B	3.18e-04	120	16	3	MP:0008045
MousePheno	abnormal mature NK cell number	HLA-H HLA-B	3.34e-04	24	16	2	MP:0013671
MousePheno	increased alpha-beta T cell number	HLA-H NUB1 MMP20 HLA-B	3.54e-04	311	16	4	MP:0012764
MousePheno	abnormal mature NK cell morphology	HLA-H HLA-B	3.63e-04	25	16	2	MP:0013700
MousePheno	urolithiasis	HLA-H HLA-B	5.60e-04	31	16	2	MP:0005360
MousePheno	abnormal CD4-positive, alpha-beta T cell number	HLA-H NUB1 MMP20 HLA-B	8.40e-04	391	16	4	MP:0008073
MousePheno	abnormal NK cell number	HLA-H NUB1 HLA-B	9.11e-04	172	16	3	MP:0008043
MousePheno	belly spot	EIF3C EIF3CL	9.81e-04	41	16	2	MP:0000373
MousePheno	abnormal NK cell morphology	HLA-H NUB1 HLA-B	1.09e-03	183	16	3	MP:0005068
MousePheno	decreased susceptibility to autoimmune diabetes	HLA-H HLA-B	1.18e-03	45	16	2	MP:0004804
MousePheno	abnormal CD4-positive, alpha beta T cell morphology	HLA-H NUB1 MMP20 HLA-B	1.27e-03	437	16	4	MP:0002432
MousePheno	decreased gamma-delta T cell number	HLA-H HLA-B	1.29e-03	47	16	2	MP:0008347
MousePheno	white spotting	EIF3C EIF3CL	1.46e-03	50	16	2	MP:0002938
MousePheno	increased lymphocyte cell number	HLA-H NUB1 MMP20 HLA-B CDH10	1.53e-03	797	16	5	MP:0005013
MousePheno	CNS inflammation	HLA-H HLA-B	1.70e-03	54	16	2	MP:0006082
MousePheno	increased T cell number	HLA-H NUB1 MMP20 HLA-B	1.73e-03	475	16	4	MP:0005015
MousePheno	decreased CD8-positive, alpha-beta T cell number	HLA-H NUB1 HLA-B	1.80e-03	218	16	3	MP:0008079
MousePheno	increased CD4-positive, alpha-beta T cell number	HLA-H MMP20 HLA-B	2.40e-03	241	16	3	MP:0008074
MousePheno	abnormal gamma-delta T cell number	HLA-H HLA-B	2.76e-03	69	16	2	MP:0008345
MousePheno	abnormal alpha-beta T cell number	HLA-H NUB1 MMP20 HLA-B	2.80e-03	542	16	4	MP:0012763
MousePheno	abnormal gamma-delta T cell morphology	HLA-H HLA-B	3.51e-03	78	16	2	MP:0008343
MousePheno	increased NK cell number	HLA-H HLA-B	3.87e-03	82	16	2	MP:0008044
MousePheno	demyelination	HLA-H HLA-B	4.15e-03	85	16	2	MP:0000921
MousePheno	abnormal effector T cell morphology	HLA-H NUB1 MMP20 HLA-B	4.79e-03	629	16	4	MP:0002435
MousePheno	abnormal alpha-beta T cell morphology	HLA-H NUB1 MMP20 HLA-B	5.10e-03	640	16	4	MP:0012762
MousePheno	decreased alpha-beta T cell number	HLA-H NUB1 HLA-B	5.10e-03	315	16	3	MP:0012765
Domain	EIF3C_N_dom	EIF3C EIF3CL	1.72e-06	2	25	2	IPR008905
Domain	eIF-3c_N	EIF3C EIF3CL	1.72e-06	2	25	2	PF05470
Domain	EIF3C	EIF3C EIF3CL	1.72e-06	2	25	2	IPR027516
Domain	MHC_I_a_C	HLA-H HLA-B	2.57e-05	6	25	2	IPR010579
Domain	MHC_I_C	HLA-H HLA-B	2.57e-05	6	25	2	PF06623
Domain	KRAB	ZNF69 ZNF763 ZNF529 ZNF433 ZNF440	9.75e-05	358	25	5	PS50805
Domain	KRAB	ZNF69 ZNF763 ZNF529 ZNF433 ZNF440	9.75e-05	358	25	5	PF01352
Domain	KRAB	ZNF69 ZNF763 ZNF529 ZNF433 ZNF440	1.12e-04	369	25	5	SM00349
Domain	KRAB	ZNF69 ZNF763 ZNF529 ZNF433 ZNF440	1.14e-04	370	25	5	IPR001909
Domain	PINT	EIF3C EIF3CL	2.04e-04	16	25	2	SM00088
Domain	PCI	EIF3C EIF3CL	2.31e-04	17	25	2	PF01399
Domain	PCI_dom	EIF3C EIF3CL	2.31e-04	17	25	2	IPR000717
Domain	MHC_I_a_a1/a2	HLA-H HLA-B	3.56e-04	21	25	2	IPR001039
Domain	MHC_I	HLA-H HLA-B	3.56e-04	21	25	2	PF00129
Domain	zf-C2H2_6	ZNF69 ZNF763 ZNF433 ZNF440	7.50e-04	314	25	4	PF13912
Domain	-	ZNF69 ZNF763 ZNF529 ZNF433 ZNF440	1.82e-03	679	25	5	3.30.160.60
Domain	zf-C2H2	ZNF69 ZNF763 ZNF529 ZNF433 ZNF440	1.99e-03	693	25	5	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF69 ZNF763 ZNF529 ZNF433 ZNF440	2.00e-03	694	25	5	IPR013087
Domain	WW_dom	GALNT9 ARHGAP12	2.19e-03	52	25	2	IPR001202
Domain	C1-set	HLA-H HLA-B	2.36e-03	54	25	2	PF07654
Domain	IGc1	HLA-H HLA-B	2.53e-03	56	25	2	SM00407
Domain	Ig_C1-set	HLA-H HLA-B	2.72e-03	58	25	2	IPR003597
Domain	Ig/MHC_CS	HLA-H HLA-B	2.72e-03	58	25	2	IPR003006
Domain	IG_MHC	HLA-H HLA-B	2.90e-03	60	25	2	PS00290
Domain	ZINC_FINGER_C2H2_2	ZNF69 ZNF763 ZNF529 ZNF433 ZNF440	3.23e-03	775	25	5	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF69 ZNF763 ZNF529 ZNF433 ZNF440	3.27e-03	777	25	5	PS00028
Domain	TPR-like_helical_dom	NUB1 SEL1L2 TTC29	3.60e-03	233	25	3	IPR011990
Domain	Znf_C2H2-like	ZNF69 ZNF763 ZNF529 ZNF433 ZNF440	3.62e-03	796	25	5	IPR015880
Domain	Znf_C2H2	ZNF69 ZNF763 ZNF529 ZNF433 ZNF440	3.80e-03	805	25	5	IPR007087
Domain	ZnF_C2H2	ZNF69 ZNF763 ZNF529 ZNF433 ZNF440	3.86e-03	808	25	5	SM00355
Domain	SH3_9	CTTN ARHGAP12	4.85e-03	78	25	2	PF14604
Domain	SH3_1	CTTN ARHGAP12	2.01e-02	164	25	2	PF00018
Pathway	REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY	HLA-H HLA-B	5.51e-05	9	18	2	MM14527
Pathway	REACTOME_ER_PHAGOSOME_PATHWAY	HLA-H HLA-B	2.33e-04	18	18	2	MM14525
Pathway	BIOCARTA_CTL_PATHWAY	HLA-H HLA-B	2.89e-04	20	18	2	MM1374
Pathway	BIOCARTA_NKCELLS_PATHWAY	HLA-H HLA-B	4.54e-04	25	18	2	MM1465
Pathway	REACTOME_ANTIGEN_PRESENTATION_FOLDING_ASSEMBLY_AND_PEPTIDE_LOADING_OF_CLASS_I_MHC	HLA-H HLA-B	4.54e-04	25	18	2	MM15713
Pathway	WP_TRANSLATION_FACTORS	EIF3C EIF3CL	1.89e-03	51	18	2	MM15881
Pathway	REACTOME_COLLAGEN_DEGRADATION	COL19A1 MMP20	2.04e-03	53	18	2	MM14566
Pathway	REACTOME_DAP12_INTERACTIONS	HLA-H HLA-B	2.12e-03	54	18	2	MM14871
Pathway	WP_PROTEASOME_DEGRADATION	HLA-H HLA-B	2.28e-03	56	18	2	MM15901
Pathway	REACTOME_COLLAGEN_DEGRADATION	COL19A1 MMP20	2.96e-03	64	18	2	M26953
Pathway	REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S	EIF3C EIF3CL	3.05e-03	65	18	2	MM15416
Pubmed	EIF3C Promotes Lung Cancer Tumorigenesis by Regulating the APP/HSPA1A/LMNB1 Axis.	EIF3C EIF3CL	4.96e-07	2	25	2	36157221
Pubmed	Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies.	EIF3C EIF3CL	2.97e-06	4	25	2	10504338
Pubmed	Secretion of a transplantation-related antigen.	HLA-H HLA-B	7.43e-06	6	25	2	6411351
Pubmed	Embryonal carcinoma cells express Qa and Tla class I genes of the major histocompatibility complex.	HLA-H HLA-B	7.43e-06	6	25	2	2740345
Pubmed	Chemosensory recognition of phenotypes determined by the Tla and H-2K regions of chromosome 17 of the mouse.	HLA-H HLA-B	7.43e-06	6	25	2	6961454
Pubmed	Organization of the AKR Qa region: structure of a divergent class I sequence, Q5k.	HLA-H HLA-B	7.43e-06	6	25	2	2639903
Pubmed	Characteristics of the expression of the murine soluble class I molecule (Q10).	HLA-H HLA-B	7.43e-06	6	25	2	3940270
Pubmed	The class I-b molecule Qa-1 forms heterodimers with H-2Ld and a novel 50-kD glycoprotein encoded centromeric to I-E beta.	HLA-H HLA-B	7.43e-06	6	25	2	7836920
Pubmed	Preferential survival of mice expressing the Qa-2 antigen.	HLA-H HLA-B	7.43e-06	6	25	2	8283431
Pubmed	QUOD ERAT FACIENDUM: sequence analysis of the H2-D and H2-Q regions of 129/SvJ mice.	HLA-H HLA-B	7.43e-06	6	25	2	12389096
Pubmed	Clonal analysis of the anti-Qa-1 cytotoxic T lymphocyte repertoire: definition of the Qa-1d and Qa-1c alloantigens and cross-reactivity with H-2.	HLA-H HLA-B	7.43e-06	6	25	2	2416805
Pubmed	Occurrence of a unique MHC class I gene in distantly related members of the genus Mus.	HLA-H HLA-B	7.43e-06	6	25	2	3988322
Pubmed	Correlation of Qa-1 determinants defined by antisera and by cytotoxic T lymphocytes.	HLA-H HLA-B	7.43e-06	6	25	2	2580784
Pubmed	Recognition of alternate alleles and mapping of the Qa1 locus.	HLA-H HLA-B	7.43e-06	6	25	2	7276576
Pubmed	Revised nomenclature of mouse H-2 genes.	HLA-H HLA-B	7.43e-06	6	25	2	2228044
Pubmed	Genetic mapping in the major histocompatibility complex by restriction enzyme site polymorphisms: most mouse class I genes map to the Tla complex.	HLA-H HLA-B	7.43e-06	6	25	2	6304710
Pubmed	The Qa-1 alloantigens. II. Evidence for the expression of two Qa-1 molecules by the Qa-1d genotype and for cross-reactivity between Qa-1 and H-2K.	HLA-H HLA-B	7.43e-06	6	25	2	6822734
Pubmed	Multiple receptors converge on H2-Q10 to regulate NK and γδT-cell development.	HLA-H HLA-B	7.43e-06	6	25	2	30537346
Pubmed	Developmental expression of the mouse MHC Q genes.	HLA-H HLA-B	7.43e-06	6	25	2	8732475
Pubmed	A nonpolymorphic class I gene in the murine major histocompatibility complex.	HLA-H HLA-B	7.43e-06	6	25	2	6420070
Pubmed	Spatial-Temporal Expression of Non-classical MHC Class I Molecules in the C57 Mouse Brain.	HLA-H HLA-B	7.43e-06	6	25	2	26040564
Pubmed	Host Expression of the CD8 Treg/NK Cell Restriction Element Qa-1 is Dispensable for Transplant Tolerance.	HLA-H HLA-B	7.43e-06	6	25	2	28894277
Pubmed	Identification of a recombinogenic major histocompatibility complex Q gene with diverse alleles.	HLA-H HLA-B	7.43e-06	6	25	2	8496692
Pubmed	The Qa-1 alloantigens. III. Biochemical analysis of the structure and extent of polymorphism of the Qa-1 allelic products.	HLA-H HLA-B	7.43e-06	6	25	2	3925004
Pubmed	Down-regulation of major histocompatibility complex Q1b gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin.	HLA-H HLA-B	7.43e-06	6	25	2	9368027
Pubmed	Three classes of mouse H-2 messenger RNA distinguished by analysis of cDNA clones.	HLA-H HLA-B	7.43e-06	6	25	2	6276751
Pubmed	Transporters associated with antigen processing (TAP)-independent presentation of soluble insulin to alpha/beta T cells by the class Ib gene product, Qa-1(b).	HLA-H HLA-B	7.43e-06	6	25	2	9730897
Pubmed	Qa antigens and their differential distribution on lymphoid, myeloid and stem cells.	HLA-H HLA-B	7.43e-06	6	25	2	6399516
Pubmed	Organization and structure of the Qa genes of the major histocompatibility complex of the C3H mouse: implications for Qa function and class I evolution.	HLA-H HLA-B	7.43e-06	6	25	2	2767053
Pubmed	Polymorphism of a Qa-1-associated antigen defined by cytotoxic T cells. I. Qed-1a and Qed-1d.	HLA-H HLA-B	7.43e-06	6	25	2	6978819
Pubmed	Qed-1--a target for unrestricted killing by T cells.	HLA-H HLA-B	7.43e-06	6	25	2	6967411
Pubmed	Biochemical identification of the Qa-1 alloantigen.	HLA-H HLA-B	7.43e-06	6	25	2	7026427
Pubmed	DNA sequences of mouse H-2 and Qa genes.	HLA-H HLA-B	1.04e-05	7	25	2	2592022
Pubmed	Evolution of the mouse H-2K region: a hot spot of mutation associated with genes transcribed in embryos and/or germ cells.	HLA-H HLA-B	1.04e-05	7	25	2	1348042
Pubmed	Organization and evolution of the class I gene family in the major histocompatibility complex of the C57BL/10 mouse.	HLA-H HLA-B	1.04e-05	7	25	2	6088985
Pubmed	Molecular organization of the D-Qa region of t-haplotypes suggests that recombination is an important mechanism for generating genetic diversity of the major histocompatibility complex.	HLA-H HLA-B	1.04e-05	7	25	2	1686840
Pubmed	Generation of a functional cDNA encoding the LdH2 class-I molecule by using a single-LTR retroviral shuttle vector.	HLA-H HLA-B	1.04e-05	7	25	2	1705528
Pubmed	Crystal structure of an MHC class I presented glycopeptide that generates carbohydrate-specific CTL.	HLA-H HLA-B	1.04e-05	7	25	2	10023770
Pubmed	Different exon-intron organization at the 5' part of a mouse class I gene is used to generate a novel H-2Kd-related mRNA.	HLA-H HLA-B	1.04e-05	7	25	2	6143316
Pubmed	Manufacture of a functional cDNA for the H-2Db molecule using a retroviral shuttle vector.	HLA-H HLA-B	1.04e-05	7	25	2	1713192
Pubmed	Further studies on polymorphic expression of GM1 and GD1a in mouse liver. The presence of a third allele on the Ggm-1 locus.	HLA-H HLA-B	1.04e-05	7	25	2	2808323
Pubmed	Major histocompatibility complex (MHC) class I KbDb -/- deficient mice possess functional CD8+ T cells and natural killer cells.	HLA-H HLA-B	1.04e-05	7	25	2	9770513
Pubmed	Primary structure of murine major histocompatibility complex alloantigens. Amino acid sequence of the NH2-terminal ninety-eight residues of the H-2Db glycoprotein.	HLA-H HLA-B	1.04e-05	7	25	2	7225204
Pubmed	CD8+ T-cell expansion and maintenance after recombinant adenovirus immunization rely upon cooperation between hematopoietic and nonhematopoietic antigen-presenting cells.	HLA-H HLA-B	1.04e-05	7	25	2	21088134
Pubmed	H2-K(b) and H2-D(b) regulate cerebellar long-term depression and limit motor learning.	HLA-H HLA-B	1.04e-05	7	25	2	19346486
Pubmed	MHC class I H2-Kb negatively regulates neural progenitor cell proliferation by inhibiting FGFR signaling.	HLA-H HLA-B	1.04e-05	7	25	2	34181639
Pubmed	The Tla locus: a new allele and antigenic specificity.	HLA-H HLA-B	1.04e-05	7	25	2	69663
Pubmed	Liver sinusoidal endothelial cells veto CD8 T cell activation by antigen-presenting dendritic cells.	HLA-H HLA-B	1.04e-05	7	25	2	18383043
Pubmed	MHC class I genes are not imprinted in the mouse placenta.	HLA-H HLA-B	1.04e-05	7	25	2	8206527
Pubmed	Thymus-dependent memory phenotype CD8 T cells in naive B6.H-2Kb-/-Db-/- animals mediate an antigen-specific response against Listeria monocytogenes.	HLA-H HLA-B	1.04e-05	7	25	2	16272298
Pubmed	Direct link between mhc polymorphism, T cell avidity, and diversity in immune defense.	HLA-H HLA-B	1.04e-05	7	25	2	12459592
Pubmed	Ethanol metabolism alters major histocompatibility complex class I-restricted antigen presentation in liver cells.	HLA-H HLA-B	1.04e-05	7	25	2	19195028
Pubmed	Tissue-specific expression of an unusual H-2 (class I)-related gene.	HLA-H HLA-B	1.04e-05	7	25	2	6956903
Pubmed	A physical map of the Q region of B1O.P.	HLA-H HLA-B	1.04e-05	7	25	2	8833240
Pubmed	Multiple sequences related to classical histocompatibility antigens in the mouse genome.	HLA-H HLA-B	1.04e-05	7	25	2	6264319
Pubmed	Transplantation tolerance to a single noninherited MHC class I maternal alloantigen studied in a TCR-transgenic mouse model.	HLA-H HLA-B	1.04e-05	7	25	2	21178009
Pubmed	Expression and function of transplantation antigens with altered or deleted cytoplasmic domains.	HLA-H HLA-B	1.04e-05	7	25	2	6604582
Pubmed	Identification of the class I genes of the mouse major histocompatibility complex by DNA-mediated gene transfer.	HLA-H HLA-B	1.04e-05	7	25	2	6815535
Pubmed	Conservation and diversity in the class I genes of the major histocompatibility complex: sequence analysis of a Tlab gene and comparison with a Tlac gene.	HLA-H HLA-B	1.04e-05	7	25	2	3456611
Pubmed	Natural killer cell education in mice with single or multiple major histocompatibility complex class I molecules.	HLA-H HLA-B	1.04e-05	7	25	2	15809355
Pubmed	Sequence analysis of the C3H H-2K1k gene: relationship to the H-2 loci.	HLA-H HLA-B	1.04e-05	7	25	2	2714856
Pubmed	Class I MHC molecules on hematopoietic cells can support intrathymic positive selection of T cell receptor transgenic T cells.	HLA-H HLA-B	1.04e-05	7	25	2	10500200
Pubmed	Structural definition of the H-2Kd peptide-binding motif.	HLA-H HLA-B	1.04e-05	7	25	2	16473882
Pubmed	Isolation of a cDNA clone for the murine transplantation antigen H-2Kb.	HLA-H HLA-B	1.04e-05	7	25	2	6954478
Pubmed	The murine family of gut-restricted class Ib MHC includes alternatively spliced isoforms of the proposed HLA-G homolog, "blastocyst MHC".	HLA-H HLA-B	1.04e-05	7	25	2	16210630
Pubmed	HLA-G transgenic mice.	HLA-H HLA-B	1.04e-05	7	25	2	10479061
Pubmed	Blastocyst MHC, a putative murine homologue of HLA-G, protects TAP-deficient tumor cells from natural killer cell-mediated rejection in vivo.	HLA-H HLA-B	1.04e-05	7	25	2	12902470
Pubmed	Structural analysis of H-2Kf and H-2Kfm1 by using H-2K locus-specific sequences.	HLA-H HLA-B	1.04e-05	7	25	2	2391419
Pubmed	Optimized tetramer analysis reveals Ly49 promiscuity for MHC ligands.	HLA-H HLA-B	1.04e-05	7	25	2	24154624
Pubmed	CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection.	HLA-H HLA-B	1.04e-05	7	25	2	34525366
Pubmed	Expression of class I genes in the major histocompatibility complex: identification of eight distinct mRNAs in DBA/2 mouse liver.	HLA-H HLA-B	1.04e-05	7	25	2	3838699
Pubmed	Expression of the Qa-2k phenotype encoded by the Q5k gene on the surface of tumor cells derived from H-2k mice.	HLA-H HLA-B	1.04e-05	7	25	2	1740659
Pubmed	The H-2Kkml mutation: a single nucleotide substitution is responsible for multiple functional differences in a class I MHC molecule.	HLA-H HLA-B	1.04e-05	7	25	2	3374494
Pubmed	Thymus-leukemia (TL) antigens of the mouse. Analysis of TL mRNA and TL cDNA TL+ and TL- strains.	HLA-H HLA-B	1.04e-05	7	25	2	3840195
Pubmed	Extensive deletions in the Q region of the mouse major histocompatibility complex.	HLA-H HLA-B	1.04e-05	7	25	2	3025084
Pubmed	DNA sequence of a class I pseudogene from the Tla region of the murine MHC: recombination at a B2 alu repetitive sequence.	HLA-H HLA-B	1.04e-05	7	25	2	2543831
Pubmed	Embryonic mouse STO cell-derived xenografts express hepatocytic functions in the livers of nonimmunosuppressed adult rats.	HLA-H HLA-B	1.04e-05	7	25	2	15671142
Pubmed	GENETIC BASIS OF SUSCEPTIBILITY TO VIRAL LEUKAEMOGENESIS.	HLA-H HLA-B	1.04e-05	7	25	2	14215561
Pubmed	Tolerance and MHC restriction in transgenic mice expressing a MHC class I gene in erythroid cells.	HLA-H HLA-B	1.04e-05	7	25	2	1540549
Pubmed	Structural relationships among the H-2 D-regions of murine MHC haplotypes.	HLA-H HLA-B	1.04e-05	7	25	2	2909618
Pubmed	Mouse histocompatibility genes: structure and organisation of a Kd gene.	HLA-H HLA-B	1.04e-05	7	25	2	11894934
Pubmed	Overexpression of MHC class I heavy chain protein in young skeletal muscle leads to severe myositis: implications for juvenile myositis.	HLA-H HLA-B	1.04e-05	7	25	2	19700752
Pubmed	A saturation hypothesis to explain both enhanced and impaired learning with enhanced plasticity.	HLA-H HLA-B	1.04e-05	7	25	2	28234229
Pubmed	The DNA sequence of the H-2kb gene: evidence for gene conversion as a mechanism for the generation of polymorphism in histocompatibilty antigens.	HLA-H HLA-B	1.04e-05	7	25	2	11894963
Pubmed	Interaction of H-2Db with mutant histocompatibility gene H (KH-11) in the mouse.	HLA-H HLA-B	1.04e-05	7	25	2	6242891
Pubmed	Immune-privileged embryonic Swiss mouse STO and STO cell-derived progenitor cells: major histocompatibility complex and cell differentiation antigen expression patterns resemble those of human embryonic stem cell lines.	HLA-H HLA-B	1.04e-05	7	25	2	16836618
Pubmed	Skewing of the NK cell repertoire by MHC class I via quantitatively controlled enrichment and contraction of specific Ly49 subsets.	HLA-H HLA-B	1.04e-05	7	25	2	22287714
Pubmed	Characterization of a severe parenchymal phenotype of experimental autoimmune encephalomyelitis in (C57BL6xB10.PL)F1 mice.	HLA-H HLA-B	1.04e-05	7	25	2	17512611
Pubmed	Family organization of mouse H-2 class I genes.	HLA-H HLA-B	1.04e-05	7	25	2	3997208
Pubmed	The class I major histocompatibility antigen gene activated in a line of SV40-transformed mouse cells is H-2Dd, not Qa/Tla.	HLA-H HLA-B	1.04e-05	7	25	2	2989712
Pubmed	The murine MHC class I genes, H-2Dq and H-2Lq, are strikingly homologous to each other, H-2Ld, and two genes reported to encode tumor-specific antigens.	HLA-H HLA-B	1.04e-05	7	25	2	3263465
Pubmed	Amino acid sequence of residues 1-98 of the K-2Kb murine major histocompatibility alloantigen: comparison with H-2Kb and H-2db reveals extensive localized differences.	HLA-H HLA-B	1.04e-05	7	25	2	7018573
Pubmed	Unique biochemical properties of a mutant MHC class I molecule, H-2Ksm1.	HLA-H HLA-B	1.04e-05	7	25	2	1280760
Pubmed	Molecular basis of the dm1 mutation in the major histocompatibility complex of the mouse: a D/L hybrid gene.	HLA-H HLA-B	1.04e-05	7	25	2	2997361
Pubmed	Expression of GM1 and GD1a in mouse liver is linked to the H-2 complex on chromosome 17.	HLA-H HLA-B	1.04e-05	7	25	2	6671979
Pubmed	Three cDNA clones encoding mouse transplantation antigens: homology to immunoglobulin genes.	HLA-H HLA-B	1.04e-05	7	25	2	6786753
Pubmed	Detection of a secreted form of the murine H-2 class I antigen with an antibody against its predicted carboxyl terminus.	HLA-H HLA-B	1.04e-05	7	25	2	6583704
Pubmed	The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells.	HLA-H HLA-B	1.04e-05	7	25	2	18974374
Pubmed	Structural analysis of H-2Kj and H-2Ku.	HLA-H HLA-B	1.04e-05	7	25	2	8168857
Pubmed	BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs.	HLA-H HLA-B	1.04e-05	7	25	2	20534453
Interaction	ZNF763 interactions	ZNF69 ZNF763	2.21e-05	6	25	2	int:ZNF763
Cytoband	19p13.2	ZNF69 ZNF763 ZNF433 ZNF440	7.03e-06	229	25	4	19p13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	ZNF69 ZNF763 ZNF433 ZNF440	8.53e-04	797	25	4	chr19p13
Cytoband	16p11.2	EIF3C EIF3CL	4.85e-03	191	25	2	16p11.2
Cytoband	6p21.3	HLA-H HLA-B	8.16e-03	250	25	2	6p21.3
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF69 ZNF763 ZNF529 ZNF433 ZNF440	9.18e-04	718	20	5	28
GeneFamily	Histocompatibility complex\|C1-set domain containing	HLA-H HLA-B	1.07e-03	44	20	2	588
Coexpression	TABULA_MURIS_SENIS_BROWN_ADIPOSE_TISSUE_B_CELL_AGEING	HLA-H NUB1 EIF3C HLA-B OGDH EIF3CL	3.89e-07	311	25	6	MM3674
Coexpression	TABULA_MURIS_SENIS_MARROW_ERYTHROBLAST_AGEING	HLA-H EIF3C HLA-B EIF3CL	3.89e-05	203	25	4	MM3795
Coexpression	TABULA_MURIS_SENIS_LUNG_ENDOTHELIAL_CELL_OF_LYMPHATIC_VESSEL_AGEING	HLA-H HLA-B	1.04e-04	16	25	2	MM3766
Coexpression	GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_DN	HLA-H COL19A1 HLA-B	1.27e-04	103	25	3	MM476
Coexpression	WUNDER_INFLAMMATORY_RESPONSE_AND_CHOLESTEROL_DN	HLA-H HLA-B	1.48e-04	19	25	2	MM797
Coexpression	MIKKELSEN_NPC_ICP_WITH_H3K27ME3	HLA-H HLA-B	1.48e-04	19	25	2	MM862
Coexpression	TABULA_MURIS_SENIS_BLADDER_LEUKOCYTE_AGEING	HLA-H HLA-B	1.64e-04	20	25	2	MM3682
Coexpression	ZHANG_UTERUS_C1_REGENERATIVE_UP	EIF3C CTTN OGDH EIF3CL	1.81e-04	302	25	4	MM16604
Coexpression	RUAN_RESPONSE_TO_TNF_UP	HLA-H HLA-B	1.81e-04	21	25	2	MM651
Coexpression	TABULA_MURIS_SENIS_LUNG_PULMONARY_INTERSTITIAL_FIBROBLAST_AGEING	HLA-H HLA-B	2.38e-04	24	25	2	MM3773
Coexpression	RUAN_RESPONSE_TO_TNF_TROGLITAZONE_UP	HLA-H HLA-B	2.59e-04	25	25	2	MM672
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Papillary-5\|TCGA-Stomach / Sample_Type by Project: Shred V9	ZNF69 ZNF763 ZNF433 ZNF440	4.26e-07	111	25	4	eb737146969b70c619649f244998d4183237c763
ToppCell	Control-B_intermediate-1\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	SLC45A2 EIF3C HLA-B EIF3CL	2.18e-06	167	25	4	948504367ecf58144d9dd74d2ec531358fc4b309
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Papillary\|TCGA-Stomach / Sample_Type by Project: Shred V9	ZNF69 ZNF763 ZNF433	3.59e-05	115	25	3	f02675a5ee12cb35535f82433d7f3f3e8349a677
ToppCell	Mild/Remission-B_naive-1\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	SLC45A2 EIF3C EIF3CL	6.87e-05	143	25	3	bd3f5fbd4e9e4dc414682db5607494f3ce988deb
ToppCell	Control-B_intermediate-1\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	SLC45A2 EIF3C HLA-B	7.01e-05	144	25	3	984470ff6ddce4c743e2db78fa98dae055aaa273
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SLC45A2 CDH10 TTC29	9.06e-05	157	25	3	e9d0300361b06aec3c216f8af15f09e14b12a4da
ToppCell	PBMC-Severe-Myeloid-cDC-cDC-cDC_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SLC45A2 CDH10 TTC29	9.23e-05	158	25	3	e9657d8960d499832f9f9b45b5a6f4388551b7e1
ToppCell	COVID-19_Mild-Classical_Monocyte-cMono_1\|COVID-19_Mild / Disease condition and Cell class	SLC45A2 EIF3C EIF3CL	1.05e-04	165	25	3	ef709c5d3231c65d351316e1e31b9c9eba721628
ToppCell	COVID-19_Mild-Classical_Monocyte-cMono_1\|Classical_Monocyte / Disease condition and Cell class	SLC45A2 EIF3C EIF3CL	1.11e-04	168	25	3	d50078614f7af74dc2aa4081c1708a5156ac51cf
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HLA-H KCNT2 HLA-B	1.29e-04	177	25	3	85e270b4a0b0da77ffe5987a099e827c02a4adf3
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KCNT2 CDH10 GALNT9	1.29e-04	177	25	3	7e799333307448c6a94d1f33dbc59c543336f45e
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HLA-H KCNT2 HLA-B	1.38e-04	181	25	3	35bcdcd2651149692e5b150e887c0f450c81d2d4
ToppCell	COVID-19_Mild-CD4+_T_activated\|COVID-19_Mild / Disease condition and Cell class	SLC45A2 EIF3C EIF3CL	1.40e-04	182	25	3	877b6e611626628e709568747512f2827ebb2795
ToppCell	COVID-19_Mild-NK_activated\|COVID-19_Mild / Disease condition and Cell class	EIF3C HLA-B EIF3CL	1.43e-04	183	25	3	22bd05135906d0ecc4ba8c2e0a666093d1bf3b8f
ToppCell	IPF-Epithelial-Mesothelial\|World / Disease state, Lineage and Cell class	KCNT2 CTTN GALNT9	1.43e-04	183	25	3	7df20e3172a1220ff427f30181f4f0c3b7fe2d42
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-5_VIP_TOX2\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HLA-H KCNT2 HLA-B	1.47e-04	185	25	3	caf4f57f2db9ff72a652c8573e16e7ab180ffc05
ToppCell	COPD-Epithelial-Mesothelial\|World / Disease state, Lineage and Cell class	KCNT2 CTTN GALNT9	1.47e-04	185	25	3	23579988036fc1925992c31919750f9b3fe9f790
ToppCell	COPD-Epithelial-Mesothelial\|COPD / Disease state, Lineage and Cell class	KCNT2 CTTN GALNT9	1.57e-04	189	25	3	79bb2593ad5d17f94b17972884241f03a0f43770
ToppCell	PBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SLC45A2 EIF3C EIF3CL	1.62e-04	191	25	3	c9f3bdb5c0a90268cab24a0fe4c3a8290fcedeb8
ToppCell	PBMC-Mild-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SLC45A2 EIF3C EIF3CL	1.64e-04	192	25	3	b86476037ddf8904c1d8a6b3763af7242c031cf3
ToppCell	BL-critical-LOC-Epithelial-unknown_epithelial\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	EIF3C WDR5B TTC29	1.69e-04	194	25	3	6140ff8e776429c9593607da418b2d9c4f399d41
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	EIF3C HLA-B EIF3CL	1.85e-04	200	25	3	2281debd86e5d92e8fe0397aec9ef670800f7471
ToppCell	Neuronal-Inhibitory-iA-iA_3(VIP)-VIP_2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HLA-H KCNT2 HLA-B	1.85e-04	200	25	3	913487e065dd580c9cbcbb3c3fc76a8d446f8856
Disease	Premature atrial contractions	ZNF69 ZNF433 ZNF440	1.37e-05	55	25	3	HP_0006699
Disease	susceptibility to cold sores measurement	HLA-H HLA-B	1.39e-03	65	25	2	EFO_0008402
Disease	skin neoplasm	SLC45A2 HLA-B	1.79e-03	74	25	2	EFO_0004198
Disease	interleukin 18 measurement	COL19A1 HLA-B	1.89e-03	76	25	2	EFO_0004581
Disease	cognitive function measurement, self reported educational attainment	EIF3C HLA-B EIF3CL	3.26e-03	355	25	3	EFO_0004784, EFO_0008354
Disease	omega-3 polyunsaturated fatty acid measurement	HLA-B OGDH	4.48e-03	118	25	2	EFO_0010119
Disease	keratinocyte carcinoma	SLC45A2 HLA-B	4.48e-03	118	25	2	EFO_0010176
Disease	lifestyle measurement, maximum cigarettes per day measurement	COL19A1 KCNT2	4.78e-03	122	25	2	EFO_0009264, EFO_0010724
Disease	Squamous cell carcinoma	SLC45A2 CTTN	4.93e-03	124	25	2	C0007137
Disease	docosahexaenoic acid measurement	HLA-B OGDH	5.17e-03	127	25	2	EFO_0007761
Disease	forced expiratory volume, response to bronchodilator	KCNT2 CTTN TTC29	6.12e-03	445	25	3	EFO_0004314, GO_0097366
Disease	cholesterol:total lipids ratio, low density lipoprotein cholesterol measurement	HLA-B OGDH	6.59e-03	144	25	2	EFO_0004611, EFO_0020943

Protein segments in the cluster

Peptide	Gene	Start	Entry
GYEQHAYDGKDYIAL	HLA-H	136	P01893
YHSGNDVEAYEYLNK	NUB1	351	Q9Y5A7
DGQEAEGKYEEYGYN	GALNT9	106	Q9HCQ5
KSCQHNYYEDAKAYG	KCNT2	701	Q6UVM3
GHDQYAYDGKDYIAL	HLA-B	136	P01889
KHVDDQGRQYYYSAD	ARHGAP12	366	Q8IWW6
CQEEHKNQGYYDYVK	OGDH	956	Q02218
HKQGTYGGYFRDQKD	EIF3C	876	Q99613
DHKQGTYGGYFRDQK	EIF3CL	876	B5ME19
DYQYVGKLHSDQDKG	CDH10	71	Q9Y6N8
YYNKDNKGNDEHEAG	COL19A1	441	Q14993
YEYGSIEKVKNGYVN	SLC45A2	266	Q9UMX9
AQAYLDKYYTNKEGH	MMP20	41	O60882
KIGDYHYYGYGTKKD	SEL1L2	556	Q5TEA6
RGDIGHKAYEYQEYG	ZNF440	126	Q8IYI8
YDGKYEKTLYGHNLE	WDR5B	71	Q86VZ2
HESQQDYSKGFGGKY	CTTN	296	Q14247
GDIYNEKGYYNKASE	TTC29	361	Q8NA56
YQVDYDNHALYKHGK	ZCCHC4	336	Q9H5U6
RGDIGHKAYEYQEYG	ZNF69	146	Q9UC07
FDEYQKIHTGGKNYE	ZNF529	186	Q6P280
RGDIGHKAYEYQDYA	ZNF763	126	Q0D2J5
QKEYSKNYGKYEEGN	TTL	246	Q8NG68
DTGHKAYEYQEYGQK	ZNF433	126	Q8N7K0
IAKDKNYGSYYGVGD	ZP4	321	Q12836