Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionheat shock protein binding

CDC37 STIP1 ULK1 DNAJA1 CLTC

7.83e-06163345GO:0031072
GeneOntologyMolecularFunctionclathrin light chain binding

CLTCL1 CLTC

5.88e-057342GO:0032051
GeneOntologyMolecularFunctionHsp90 protein binding

CDC37 STIP1 ULK1

1.11e-0455343GO:0051879
GeneOntologyCellularComponentAtg1/ULK1 kinase complex

ATG101 ULK1

8.64e-059332GO:1990316
GeneOntologyCellularComponentclathrin complex

CLTCL1 CLTC

8.64e-059332GO:0071439
GeneOntologyCellularComponentclathrin coat of trans-Golgi network vesicle

CLTCL1 CLTC

3.64e-0418332GO:0030130
GeneOntologyCellularComponenttrans-Golgi network transport vesicle membrane

CLTCL1 CLTC

5.47e-0422332GO:0012510
GeneOntologyCellularComponentclathrin vesicle coat

CLTCL1 CLTC

1.64e-0338332GO:0030125
GeneOntologyCellularComponentphagophore assembly site

ATG101 ULK1

1.73e-0339332GO:0000407
GeneOntologyCellularComponenttrans-Golgi network transport vesicle

CLTCL1 CLTC

1.82e-0340332GO:0030140
GeneOntologyCellularComponentserine/threonine protein kinase complex

ATG101 ULK1 CDK10

1.92e-03157333GO:1902554
GeneOntologyCellularComponentprotein folding chaperone complex

CDC37 STIP1

2.00e-0342332GO:0101031
GeneOntologyCellularComponentprotein kinase complex

ATG101 ULK1 CDK10

2.41e-03170333GO:1902911
GeneOntologyCellularComponentclathrin coat

CLTCL1 CLTC

3.53e-0356332GO:0030118
GeneOntologyCellularComponentGolgi-associated vesicle membrane

CLTCL1 CLTC

4.17e-0361332GO:0030660
GeneOntologyCellularComponentmyelin sheath

STIP1 ENO2 CLTC

4.78e-03217333GO:0043209
GeneOntologyCellularComponentvesicle coat

CLTCL1 CLTC

5.01e-0367332GO:0030120
DomainClathrin_H-chain_link/propller

CLTCL1 CLTC

3.22e-062342IPR016025
DomainClathrin_H-chain_propeller_rpt

CLTCL1 CLTC

3.22e-062342IPR022365
DomainClathrin_propel

CLTCL1 CLTC

3.22e-062342PF01394
DomainClathrin_heavy_chain

CLTCL1 CLTC

3.22e-062342IPR016341
DomainClathrin_H-chain_linker_core

CLTCL1 CLTC

3.22e-062342IPR015348
DomainClathrin-link

CLTCL1 CLTC

3.22e-062342PF09268
Domain-

CLTCL1 CLTC

3.22e-0623422.130.10.110
DomainClathrin_H-chain_propeller_N

CLTCL1 CLTC

3.22e-062342IPR001473
DomainClathrin_H-chain_linker

CLTCL1 CLTC

9.64e-063342IPR012331
DomainCLH

CLTCL1 CLTC

9.64e-063342SM00299
DomainClathrin

CLTCL1 CLTC

6.72e-057342PF00637
DomainCHCR

CLTCL1 CLTC

6.72e-057342PS50236
DomainClathrin_H-chain/VPS_repeat

CLTCL1 CLTC

8.95e-058342IPR000547
DomainSer/Thr_kinase_AS

DCLK3 ULK1 STK31 CDK10

3.87e-03357344IPR008271
DomainS_TKc

DCLK3 ULK1 STK31 CDK10

3.95e-03359344SM00220
DomainPROTEIN_KINASE_ST

DCLK3 ULK1 STK31 CDK10

4.07e-03362344PS00108
DomainPkinase

DCLK3 ULK1 STK31 CDK10

4.87e-03381344PF00069
Domain-

STIP1 CLTCL1 CLTC

6.23e-032073431.25.40.10
DomainCa/CaM-dep_Ca-dep_prot_Kinase

DCLK3 ULK1

6.99e-0369342IPR020636
PathwayKEGG_MEDICUS_REFERENCE_C9ORF72_MEDIATED_AUTOPHAGY_INITIATION

ATG101 ULK1

9.10e-058262M47746
Pubmed

Characterization of a second human clathrin heavy chain polypeptide gene (CLH-22) from chromosome 22q11.

CLTCL1 CLTC

9.84e-0723528733129
Pubmed

CHC22 and CHC17 clathrins have distinct biochemical properties and display differential regulation and function.

CLTCL1 CLTC

9.84e-07235229097553
Pubmed

The clathrin heavy chain isoform CHC22 functions in a novel endosomal sorting step.

CLTCL1 CLTC

9.84e-07235220065094
Pubmed

The Hsp90 co-chaperones Cdc37 and Sti1 interact physically and genetically.

CDC37 STIP1

9.84e-07235212437126
Pubmed

Serine/Threonine Kinase Unc-51-like Kinase-1 (Ulk1) Phosphorylates the Co-chaperone Cell Division Cycle Protein 37 (Cdc37) and Thereby Disrupts the Stability of Cdc37 Client Proteins.

CDC37 ULK1

9.84e-07235228073914
Pubmed

Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins.

CDC37 STIP1 DNAJA1

1.05e-062035322504172
Pubmed

Functional equivalence of the clathrin heavy chains CHC17 and CHC22 in endocytosis and mitosis.

CLTCL1 CLTC

2.95e-06335219509056
Pubmed

Clathrin promotes centrosome integrity in early mitosis through stabilization of centrosomal ch-TOG.

CLTCL1 CLTC

2.95e-06335222891263
Pubmed

A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy.

ATG101 ULK1

2.95e-06335219287211
Pubmed

Spinal cord repair: future directions.

GTF3A CLTC

2.95e-0633521589293
Pubmed

Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration.

CLTCL1 CLTC

2.95e-06335215133132
Pubmed

Structure of the Human Atg13-Atg101 HORMA Heterodimer: an Interaction Hub within the ULK1 Complex.

ATG101 ULK1

2.95e-06335226299944
Pubmed

Label-free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5.

CDC37 STIP1 DNAJA1

3.35e-062935321360678
Pubmed

Network organization of the human autophagy system.

ATG101 CDC37 RABGAP1 ULK1 AGPS CLTC

4.53e-0643735620562859
Pubmed

SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation.

CDC37 STIP1

5.90e-06435224880080
Pubmed

Oxidative inhibition of Hsp90 disrupts the super-chaperone complex and attenuates pancreatic adenocarcinoma in vitro and in vivo.

CDC37 STIP1

5.90e-06435222729780
Pubmed

HIP1 functions in clathrin-mediated endocytosis through binding to clathrin and adaptor protein 2.

CLTCL1 CLTC

5.90e-06435211517213
Pubmed

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.

CDC37 STIP1 RABGAP1 PRKCSH AGPS DNAJA1 JCHAIN CLTC HDLBP

6.11e-06136735932687490
Pubmed

Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease.

ZNF462 PPP1R21 DNAJA1 CDK10 CLTC HDLBP

6.31e-0646335627503909
Pubmed

CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.

CDC37 BARD1 STIP1 PRKCSH DNAJA1 CLTC

9.12e-0649435626831064
Pubmed

Autophagic Flux Is Regulated by Interaction Between the C-terminal Domain of PATCHED1 and ATG101.

ATG101 ULK1

9.82e-06535229453315
Pubmed

Atg101, a novel mammalian autophagy protein interacting with Atg13.

ATG101 ULK1

9.82e-06535219597335
Pubmed

Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy.

CDC37 ULK1

9.82e-06535221855797
Pubmed

Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic.

CLTCL1 CLTC

9.82e-06535210436022
Pubmed

EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.

STIP1 PRKCSH AGPS DNAJA1 ENO2 CLTC HDLBP

1.30e-0580335736517590
Pubmed

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery.

ATG101 ULK1

1.47e-05635219225151
Pubmed

Asymmetric Hsp90 N domain SUMOylation recruits Aha1 and ATP-competitive inhibitors.

CDC37 STIP1

1.47e-05635224462205
Pubmed

Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism.

ATG101 ULK1

1.47e-05635218936157
Pubmed

WDFY4 is required for cross-presentation in response to viral and tumor antigens.

STIP1 ULK1 DNAJA1 CLTC

1.83e-0515635430409884
Pubmed

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

CDC37 STIP1 DNAJA1 ENO2 HDLBP

1.84e-0532735515592455
Pubmed

A STUB1 ubiquitin ligase/CHIC2 protein complex negatively regulates the IL-3, IL-5, and GM-CSF cytokine receptor common β chain (CSF2RB) protein stability.

CDC37 DNAJA1 CLTC

1.88e-055135336108743
Pubmed

Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function.

CDC37 STIP1

2.06e-05735220159553
Pubmed

A central role for the Hsp90.Cdc37 molecular chaperone module in interleukin-1 receptor-associated-kinase-dependent signaling by toll-like receptors.

CDC37 STIP1

2.06e-05735215647277
Pubmed

Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop.

ATG101 ULK1

2.06e-05735221460634
Pubmed

A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy.

ATG101 ULK1

2.06e-05735227617292
Pubmed

A role for the CHC22 clathrin heavy-chain isoform in human glucose metabolism.

CLTCL1 CLTC

2.06e-05735219478182
Pubmed

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.

ATG101 ULK1

2.06e-05735221258367
Pubmed

EIF3H Orchestrates Hippo Pathway-Mediated Oncogenesis via Catalytic Control of YAP Stability.

DNAJA1 CLTC HDLBP

2.36e-055535332269044
Pubmed

Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity.

CDC37 STIP1

2.74e-05835222315411
Pubmed

Distinct roles of molecular chaperones HSP90α and HSP90β in the biogenesis of KCNQ4 channels.

STIP1 DNAJA1

2.74e-05835223431407
Pubmed

Structural basis of the autophagy-related LC3/Atg13 LIR complex: recognition and interaction mechanism.

ATG101 ULK1

2.74e-05835224290141
Pubmed

Co-chaperone FKBP38 promotes HERG trafficking.

STIP1 DNAJA1

2.74e-05835217569659
Pubmed

The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy.

ATG101 ULK1

2.74e-05835230669939
Pubmed

HSP40 binding is the first step in the HSP90 chaperoning pathway for the progesterone receptor.

STIP1 DNAJA1

2.74e-05835211809754
Pubmed

Combined treatment of human multiple myeloma cells with bortezomib and doxorubicin alters the interactome of 20S proteasomes.

DCLK3 STIP1 DNAJA1

2.77e-055835330009671
Pubmed

A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein.

CDC37 STIP1 PLCE1

3.23e-056135319875381
Pubmed

Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients.

CDC37 STIP1

3.53e-05935229127155
Pubmed

FIP200 regulates targeting of Atg16L1 to the isolation membrane.

ATG101 ULK1

3.53e-05935223392225
Pubmed

Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors.

CDC37 STIP1

3.53e-05935226804907
Pubmed

Downregulation of the FBXO43 gene inhibits tumor growth in human breast cancer by limiting its interaction with PCNA.

CDC37 STIP1 CLTC

3.91e-056535334645483
Pubmed

Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.

CDC37 STIP1 CLTCL1 DNAJA1

4.38e-0519535417110338
Pubmed

CALM regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature.

CLTCL1 CLTC

4.40e-051035225898166
Pubmed

Identification and characterization of Harc, a novel Hsp90-associating relative of Cdc37.

CDC37 STIP1

4.40e-051035211413142
Pubmed

Characterization of ubiquitination dependent dynamics in growth factor receptor signaling by quantitative proteomics.

CLTC MIB1

4.40e-051035221956701
Pubmed

Agrin has a pathological role in the progression of oral cancer.

CDC37 RABGAP1 CLTC HDLBP

4.56e-0519735429872149
Pubmed

Ubiquitin-specific protease 8 deubiquitinates Sec31A and decreases large COPII carriers and collagen IV secretion.

CLTCL1 CLTC

5.38e-051135229604273
Pubmed

Quantitative analysis of PPT1 interactome in human neuroblastoma cells.

STIP1 DNAJA1 ENO2 CLTC

5.84e-0521035426217791
Pubmed

Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress.

STIP1 DNAJA1 ENO2

6.74e-057835316236267
Pubmed

ULK1 inhibits the kinase activity of mTORC1 and cell proliferation.

ATG101 ULK1

7.62e-051335221795849
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

CDC37 STIP1 RABGAP1 PRKCSH DNAJA1 ARHGEF10 ENO2 HDLBP

7.89e-05145535822863883
Pubmed

HSP90 is necessary for the ACK1-dependent phosphorylation of STAT1 and STAT3.

CDC37 CLTC

8.89e-051435228739485
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

CDC37 STIP1 PRKCSH DNAJA1 ARHGEF10 CLTC HDLBP MIB1

9.18e-05148735833957083
Pubmed

Huntingtin functions as a scaffold for selective macroautophagy.

ATG101 ULK1

1.02e-041535225686248
Pubmed

Cullin-3/KCTD10 complex is essential for K27-polyubiquitination of EIF3D in human hepatocellular carcinoma HepG2 cells.

STIP1 PRKCSH AGPS

1.03e-049035331280863
Pubmed

A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.

CDC37 STIP1 PRKCSH AGPS DNAJA1 HDLBP

1.21e-0478635629128334
Pubmed

Tumor suppressor BAP1 nuclear import is governed by transportin-1.

CDC37 STIP1 PRKCSH DNAJA1 ENO2 CLTC HDLBP

1.26e-04114935735446349
Pubmed

Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.

STIP1 CLTCL1 ENO2

1.29e-049735322360420
Pubmed

Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.

CDC37 STIP1 PRKCSH DNAJA1 CLTC

1.31e-0449535528581483
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

CDC37 STIP1 PRKCSH CLTCL1 CLTC HDLBP

1.40e-0480735630575818
Pubmed

High-throughput screening of functional deubiquitinating enzymes in autophagy.

ATG101 ULK1

1.49e-041835232453962
Pubmed

Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.

RABGAP1 PRKCSH CLTCL1 DNAJA1 ENO2 CLTC

1.82e-0484735635235311
Pubmed

Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.

CDC37 PRKCSH AGPS DNAJA1 HDLBP

1.86e-0453435535032548
Pubmed

CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer.

STIP1 CLTCL1 ENO2 CLTC

1.97e-0428835431501420
Pubmed

Motor neurons control blood vessel patterning in the developing spinal cord.

ENO2 VEGFA

2.04e-042135228262664
Pubmed

The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.

CDC37 STIP1

2.04e-042135227353360
Pubmed

A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death.

STIP1 DNAJA1

2.04e-042135214532270
Pubmed

Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis.

DNAJA1 ENO2 CLTC

2.19e-0411635337117180
Pubmed

Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.

CDC37 STIP1 DNAJA1 ENO2 CLTC

2.28e-0455835535063084
Pubmed

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.

CDC37 STIP1 PRKCSH CLTCL1 DNAJA1

2.57e-0457335528330616
Pubmed

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

CDC37 STIP1 PRKCSH ULK1 AGPS DNAJA1 CLTC

2.65e-04129735733545068
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

STIP1 RABGAP1 DNAJA1 CLTC HDLBP

2.90e-0458835538580884
Pubmed

Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy.

CLTCL1 CLTC

3.15e-042635224067654
Pubmed

SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.

STIP1 PRKCSH AGPS DNAJA1 HDLBP

3.35e-0460735539147351
Pubmed

Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.

STIP1 DNAJA1 CLTC HDLBP

3.38e-0433235432786267
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

CDC37 MCM10 AGPS DNAJA1 CLTC HDLBP MIB1

3.43e-04135335729467282
Pubmed

A protein interaction landscape of breast cancer.

CDC37 BARD1 MCM10 CLTC HDLBP

4.09e-0463435534591612
Pubmed

The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors.

CDC37 STIP1 DNAJA1 HDLBP

4.13e-0435035426549023
Pubmed

Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement.

STIP1 DNAJA1

4.20e-043035225864199
Pubmed

Autophagy negatively regulates cancer cell proliferation via selectively targeting VPRBP.

CLTCL1 CLTC

4.20e-043035222963397
Pubmed

Akt-mediated valosin-containing protein 97 phosphorylation regulates its association with ubiquitinated proteins.

ENO2 CLTC

4.20e-043035216027165
Pubmed

Identification of proteins interacting with the mitochondrial small heat shock protein Hsp22 of Drosophila melanogaster: Implication in mitochondrial homeostasis.

AGPS DNAJA1 CLTC

4.30e-0414635329509794
Pubmed

∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.

CDC37 PRKCSH CLTCL1 DNAJA1 CLTC

4.49e-0464735526618866
Pubmed

Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice.

CLTC VEGFA

4.49e-043135219666558
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

CDC37 STIP1 PRKCSH AGPS DNAJA1 CLTC HDLBP

4.69e-04142535730948266
Pubmed

A genome-wide IR-induced RAD51 foci RNAi screen identifies CDC73 involved in chromatin remodeling for DNA repair.

CLTCL1 DNAJA1 CLTC

4.93e-0415335327462432
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

STIP1 PRKCSH AGPS DNAJA1 CLTC HDLBP

5.02e-04102435624711643
Pubmed

Mind bomb 1 is essential for generating functional Notch ligands to activate Notch.

VEGFA MIB1

5.09e-043335216000382
Pubmed

Atypical E2F repressors and activators coordinate placental development.

BARD1 MCM10

5.09e-043335222516201
Pubmed

Cell cycle-dependent palmitoylation of protocadherin 7 by ZDHHC5 promotes successful cytokinesis.

STIP1 DNAJA1 CLTC

5.51e-0415935336762613
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

STIP1 PRKCSH DNAJA1 CLTC HDLBP MIB1

5.70e-04104935627880917
InteractionSTAMBP interactions

ATG101 ULK1 CLTCL1 USP21 CLTC

7.03e-07104335int:STAMBP
InteractionCOPG1 interactions

ATG101 STIP1 RABGAP1 PRKCSH ARHGEF10 HDLBP

1.73e-06229336int:COPG1
InteractionMAP1LC3A interactions

ATG101 CDC37 RABGAP1 ULK1 CLTCL1 CLTC

2.32e-06241336int:MAP1LC3A
InteractionSTAMBPL1 interactions

CDC37 ULK1 CLTCL1 CLTC

6.67e-0675334int:STAMBPL1
InteractionUCHL3 interactions

STIP1 AGPS ENO2 USP21 CLTC

1.19e-05185335int:UCHL3
InteractionOFD1 interactions

CDC37 STIP1 MCM10 DNAJA1 CLTC MIB1

1.87e-05347336int:OFD1
InteractionHAX1 interactions

STIP1 RABGAP1 DNAJA1 CLTC HDLBP MIB1

4.38e-05404336int:HAX1
InteractionWRAP73 interactions

STIP1 AGPS DNAJA1 MIB1

4.71e-05123334int:WRAP73
InteractionWASHC3 interactions

ATG101 RABGAP1 ULK1 HDLBP

6.58e-05134334int:WASHC3
InteractionCDC37 interactions

ATG101 CDC37 STIP1 PRKCSH ULK1 CDK10 PLCE1

6.88e-05645337int:CDC37
InteractionSNX5 interactions

CDC37 CLTCL1 CLTC MIB1

7.18e-05137334int:SNX5
InteractionRIPK4 interactions

CDC37 STIP1 AGPS DNAJA1 CLTC MIB1

7.58e-05446336int:RIPK4
InteractionWDFY4 interactions

STIP1 ULK1 DNAJA1 CLTC

8.02e-05141334int:WDFY4
InteractionGABARAP interactions

ATG101 CDC37 ULK1 MIB1

8.94e-05145334int:GABARAP
InteractionCDK10 interactions

CDC37 STIP1 CDK10

9.37e-0554333int:CDK10
InteractionUSP19 interactions

CDC37 STIP1 ULK1 PLCE1

1.13e-04154334int:USP19
InteractionBRCA1 interactions

CDC37 BARD1 STIP1 PRKCSH MCM10 DNAJA1 CLTC HDLBP VEGFA

1.30e-041249339int:BRCA1
InteractionYWHAE interactions

ATG101 CDC37 STIP1 ULK1 MCM10 DNAJA1 USP21 CLTC HDLBP

1.36e-041256339int:YWHAE
InteractionHSP90AA1 interactions

CDC37 STIP1 RABGAP1 PRKCSH ULK1 DNAJA1 CDK10 PLCE1 VEGFA

1.42e-041263339int:HSP90AA1
InteractionATG14 interactions

ATG101 ULK1 MCM10

1.95e-0469333int:ATG14
InteractionCFAP52 interactions

STIP1 CLTCL1

2.01e-0413332int:CFAP52
InteractionSNAP91 interactions

CLTCL1 CLTC MIB1

2.03e-0470333int:SNAP91
InteractionBAG5 interactions

STIP1 DNAJA1 ARHGEF10 CLTC HDLBP

2.17e-04341335int:BAG5
InteractionMAP1LC3C interactions

ATG101 CDC37 ULK1

2.21e-0472333int:MAP1LC3C
InteractionCLTB interactions

ULK1 CLTCL1 CLTC HDLBP

2.28e-04185334int:CLTB
InteractionUSP15 interactions

CDC37 BARD1 PRKCSH DNAJA1 USP21 MIB1

2.29e-04546336int:USP15
InteractionAKR1B15 interactions

STIP1 ENO2

2.34e-0414332int:AKR1B15
InteractionFBXO43 interactions

CDC37 STIP1 CLTC

2.40e-0474333int:FBXO43
InteractionSTIL interactions

CDC37 STIP1 DNAJA1 MIB1

2.53e-04190334int:STIL
InteractionFAM120C interactions

CDC37 STIP1 HDLBP MIB1

2.58e-04191334int:FAM120C
InteractionKCNQ4 interactions

STIP1 DNAJA1

2.69e-0415332int:KCNQ4
InteractionSCYL2 interactions

STIP1 GTF3A CLTC MIB1

2.79e-04195334int:SCYL2
InteractionDDX39B interactions

CDC37 BARD1 STIP1 PRKCSH CLTC HDLBP

2.88e-04570336int:DDX39B
InteractionKCTD10 interactions

PPP1R21 STIP1 PRKCSH AGPS

2.96e-04198334int:KCTD10
InteractionPRKAG3 interactions

STIP1 ULK1 CLTCL1

3.02e-0480333int:PRKAG3
InteractionNELFE interactions

DNAJA1 ENO2 CLTC HDLBP

3.13e-04201334int:NELFE
InteractionLDHA interactions

RABGAP1 PRKCSH ULK1 CLTC HDLBP

3.36e-04375335int:LDHA
InteractionG3BP1 interactions

CDC37 STIP1 PRKCSH ULK1 AGPS DNAJA1 HDLBP

3.40e-04835337int:G3BP1
InteractionSUMO2 interactions

STIP1 PRKCSH DNAJA1 ENO2 CLTC HDLBP

3.50e-04591336int:SUMO2
InteractionCLINT1 interactions

STIP1 CLTCL1 CLTC HDLBP

3.50e-04207334int:CLINT1
InteractionCCT6B interactions

CLTCL1 DNAJA1 CDK10 CLTC

3.50e-04207334int:CCT6B
InteractionFBXO7 interactions

ZNF462 PPP1R21 DNAJA1 CDK10 CLTC HDLBP

3.72e-04598336int:FBXO7
InteractionSUMO4 interactions

STIP1 DNAJA1 ENO2

3.73e-0486333int:SUMO4
InteractionUSO1 interactions

STIP1 DNAJA1 CLTC HDLBP

4.04e-04215334int:USO1
InteractionWIPI2 interactions

ATG101 CDC37 RABGAP1

4.26e-0490333int:WIPI2
InteractionATG16L1 interactions

ATG101 CDC37 RABGAP1 ULK1 AGPS DNAJA1 CLTC HDLBP

4.51e-041161338int:ATG16L1
InteractionSLC35B2 interactions

CDC37 STIP1 CLTC

4.55e-0492333int:SLC35B2
InteractionTBK1 interactions

CDC37 STIP1 ULK1 DNAJA1 MIB1

4.61e-04402335int:TBK1
InteractionCFTR interactions

ZNF462 CDC37 PPP1R21 PRKCSH CLTCL1 DNAJA1 CLTC HDLBP VEGFA

4.65e-041480339int:CFTR
InteractionATG101 interactions

ATG101 CDC37 ULK1

4.84e-0494333int:ATG101
InteractionFNIP2 interactions

CDC37 STIP1

4.85e-0420332int:FNIP2
InteractionBTBD3 interactions

CDC37 CLTC

4.85e-0420332int:BTBD3
InteractionPLCE1 interactions

CDC37 PLCE1

4.85e-0420332int:PLCE1
InteractionUNC45A interactions

CDC37 PPP1R21 STIP1 HDLBP

5.05e-04228334int:UNC45A
InteractionOPTN interactions

CDC37 ULK1 GTF3A AGPS CLTC

5.75e-04422335int:OPTN
InteractionFLCN interactions

CDC37 STIP1 ULK1

5.80e-04100333int:FLCN
InteractionU2AF2 interactions

CDC37 BARD1 STIP1 DNAJA1 CLTC HDLBP

5.84e-04651336int:U2AF2
InteractionATP6V1B2 interactions

STIP1 AGPS CLTC HDLBP

5.93e-04238334int:ATP6V1B2
InteractionPRKACG interactions

CDC37 STIP1 DNAJA1

5.98e-04101333int:PRKACG
InteractionDENND1A interactions

USP21 CLTC HDLBP

5.98e-04101333int:DENND1A
InteractionU2AF1 interactions

BARD1 STIP1 HDLBP VEGFA

6.02e-04239334int:U2AF1
InteractionDISC1 interactions

CDC37 RABGAP1 MCM10 DNAJA1 TSPOAP1

6.20e-04429335int:DISC1
InteractionCDK5 interactions

DCLK3 CDC37 STIP1 MIB1

6.31e-04242334int:CDK5
InteractionHSPA4 interactions

CDC37 BARD1 STIP1 DNAJA1 CLTC VEGFA

6.63e-04667336int:HSPA4
InteractionTFCP2 interactions

STIP1 CLTCL1 ENO2 CLTC HDLBP

6.67e-04436335int:TFCP2
InteractionFAM221B interactions

ATG101 ULK1

7.02e-0424332int:FAM221B
InteractionASB5 interactions

DNAJA1 ENO2

7.02e-0424332int:ASB5
InteractionPINK1 interactions

CDC37 STIP1 PRKCSH ULK1 CLTC HDLBP

7.28e-04679336int:PINK1
InteractionGRK7 interactions

CDC37 HDLBP

7.62e-0425332int:GRK7
InteractionWRN interactions

BARD1 HDLBP MIB1

7.66e-04110333int:WRN
InteractionPPT1 interactions

STIP1 DNAJA1 ENO2 CLTC

7.79e-04256334int:PPT1
InteractionPPP6R3 interactions

CDC37 STIP1 DNAJA1 USP21

8.02e-04258334int:PPP6R3
InteractionFBXO42 interactions

RABGAP1 DNAJA1 CLTC HDLBP

8.13e-04259334int:FBXO42
InteractionCT45A1 interactions

CDC37 CT45A10

8.25e-0426332int:CT45A1
InteractionVARS1 interactions

ATG101 STIP1 DNAJA1 HDLBP

8.25e-04260334int:VARS1
InteractionDNAJB5 interactions

CDC37 STIP1 ARHGEF10

8.50e-04114333int:DNAJB5
InteractionRBMX interactions

ATG101 STIP1 RABGAP1 CLTC HDLBP

8.57e-04461335int:RBMX
InteractionPAICS interactions

CDC37 STIP1 PRKCSH ARHGEF10

8.61e-04263334int:PAICS
InteractionFUCA1 interactions

BARD1 USP21

8.90e-0427332int:FUCA1
InteractionAGRN interactions

CDC37 RABGAP1 CLTC HDLBP

9.11e-04267334int:AGRN
InteractionVPS35 interactions

BARD1 STIP1 HDLBP VEGFA

9.50e-04270334int:VPS35
InteractionSTRAP interactions

BARD1 STIP1 DNAJA1 HDLBP

9.50e-04270334int:STRAP
InteractionEPHA2 interactions

CDC37 PRKCSH AGPS ARHGEF10 CLTC MIB1

9.81e-04719336int:EPHA2
InteractionLAMTOR1 interactions

CDC37 STIP1 RABGAP1 DNAJA1 ARHGEF10 CLTC

1.00e-03722336int:LAMTOR1
InteractionACTR1A interactions

CDC37 STIP1 PRKCSH DNAJA1

1.00e-03274334int:ACTR1A
InteractionPGAM5 interactions

BARD1 STIP1 HDLBP MIB1

1.00e-03274334int:PGAM5
InteractionGEMIN4 interactions

BARD1 STIP1 CLTCL1 MIB1

1.00e-03274334int:GEMIN4
InteractionPRKCG interactions

CDC37 STIP1 DNAJA1

1.01e-03121333int:PRKCG
InteractionLONP1 interactions

ATG101 CDC37 STIP1 AGPS DNAJA1

1.02e-03479335int:LONP1
InteractionBAP1 interactions

CDC37 STIP1 PRKCSH DNAJA1 ENO2 USP21 CLTC HDLBP

1.02e-031314338int:BAP1
InteractionPACRG interactions

STIP1 DNAJA1

1.03e-0329332int:PACRG
InteractionSTIP1 interactions

CDC37 STIP1 DNAJA1 ARHGEF10 ENO2 CDK10 CLTC

1.03e-031006337int:STIP1
InteractionEIF3H interactions

STIP1 DNAJA1 CLTC HDLBP

1.12e-03282334int:EIF3H
InteractionPPP1CC interactions

BARD1 STIP1 DNAJA1 ENO2 CLTC HDLBP

1.12e-03738336int:PPP1CC
InteractionRIOK2 interactions

CDC37 CLTCL1 HDLBP

1.14e-03126333int:RIOK2
InteractionANKK1 interactions

CDC37 STIP1

1.17e-0331332int:ANKK1
InteractionMCM6 interactions

BARD1 STIP1 PRKCSH MCM10

1.19e-03287334int:MCM6
InteractionPKM interactions

CDC37 STIP1 ULK1 ENO2 HDLBP

1.20e-03497335int:PKM
InteractionCCDC14 interactions

STIP1 MCM10 MIB1

1.21e-03129333int:CCDC14
InteractionAHSA1 interactions

CDC37 STIP1 CLTCL1 DNAJA1

1.30e-03294334int:AHSA1
GeneFamilyAutophagy related

ATG101 ULK1

6.64e-04332121022
ToppCellCOVID_vent|World / Disease condition, Lineage, Cell class and subclass

STIP1 DNAJA1 JCHAIN CLTC HDLBP

4.81e-072003551d88e5cc4534073f27a7562e1c4b884bd67f09d9
ToppCellfacs-Marrow-T-cells-3m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGEF10 JCHAIN PLCE1 HDLBP

1.20e-0518135457f0cc749ae8b6a3d77e2af31f9a6e4739c57049
ToppCellfacs-Marrow-T-cells-3m-Hematologic-hematopoietic_stem_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGEF10 JCHAIN PLCE1 HDLBP

1.20e-05181354d01b35cc2fc57991a35be6a06cb7351fbabd9a11
ToppCellfacs-Marrow-T-cells-3m-Hematologic-Unknown_Progenitor|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARHGEF10 JCHAIN PLCE1 HDLBP

1.26e-05183354b0b835f3b1de1bd46a47e1b805aa8994cd3a4e3e
ToppCellTransverse|World / Region, Cell class and subclass

STIP1 DNAJA1 JCHAIN HDLBP

1.78e-052003549dee983d7e43af8b3fbed795d8432af67b33c3b3
ToppCellTransverse|World / shred on region, Cell_type, and subtype

STIP1 DNAJA1 JCHAIN HDLBP

1.78e-052003541b4925a17be02f99b69c45f66577986a2dc107fd
ComputationalDRG (dorsal root ganglia) genes.

RABGAP1 ULK1 ARHGEF10 ENO2 JCHAIN VEGFA

1.20e-04384236MODULE_2
Drug2evm

METAP1D CLTCL1 TSPOAP1 CLTC

1.90e-0660344CID000736259
DrugBadg

CLTCL1 CLTC

2.16e-062342CID000125951
DrugActh(11-24)

CLTCL1 ENO2 CLTC

4.60e-0622343CID003037130
DrugAC1OAR8J

CLTCL1 CLTC

1.30e-054342CID006834124
DrugN5-sulfono Flavin-adenine Dinucleotide

CLTCL1 CLTC VEGFA

1.33e-0531343CID011840982
DrugAC1L1IPS

CLTCL1 CLTC

3.23e-056342CID000004682
Drugnorfloxacin

ENO2 PLCE1 USP21

4.14e-0545343CID000004539
DrugDynasore hydrate

CLTCL1 CLTC

4.52e-057342CID005396227
DrugC12-NBD-PC

CLTCL1 CLTC

4.52e-057342CID006439314
Druggallium nitride

GTF3A CLTC

4.52e-057342CID000117559
DrugNSC330499

CDC37 STIP1

4.52e-057342CID000433447
DrugNa 7

CLTCL1 CLTC

6.03e-058342CID000446006
DrugAntagonist G

CLTCL1 CLTC

7.74e-059342CID000163960
Drug4P-PDOT

CLTCL1 CLTC

7.74e-059342CID003976006
DrugCapecitabine

STIP1 PLCE1 VEGFA

8.42e-0557343ctd:D000069287
Drugcc-637

CLTCL1 CLTC

9.67e-0510342CID000002350
Drugtetramethylrhodamine-5-maleimide

CLTCL1 CLTC

9.67e-0510342CID005289288
Drugacetylaminophenylarsine oxide

CLTCL1 CLTC

9.67e-0510342CID006337999
Drug3,6-anhydro-D-galactose 2-sulfate

CLTCL1 CLTC VEGFA

1.25e-0465343CID000446806
Drughematoxilina

ZNF462 ENO2 VEGFA MIB1

1.55e-04183344CID000010603
Drug17-AAG; Up 200; 1uM; PC3; HG-U133A

STIP1 RABGAP1 CLTCL1 DNAJA1

1.65e-04186344432_UP
Drugmaslinic acid

ULK1 VEGFA

1.67e-0413342ctd:C412811
Drug5182598; Up 200; 25uM; MCF7; HT_HG-U133A_EA

RABGAP1 CLTCL1 ARHGEF10 VEGFA

1.69e-04187344868_UP
Drugpyrvinium pamoate; Down 200; 1.25uM; MCF7; HT_HG-U133A_EA

BARD1 STIP1 MCM10 HDLBP

1.79e-04190344870_DN
DrugLY 294002; Down 200; 10uM; MCF7; HT_HG-U133A

DNAJA1 ENO2 HDLBP VEGFA

1.86e-041923441661_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; HL60; HT_HG-U133A

CLTCL1 ARHGEF10 TSPOAP1 CDK10

1.90e-041933442949_DN
Drugthiocarbohydrazide

CLTCL1 CLTC

1.95e-0414342CID002724189
Drugdiaminoguanidine

CLTCL1 CLTC

1.95e-0414342CID000151203
DrugN-Q-I

CLTCL1 CLTC

1.95e-0414342CID015942689
DrugMecamylamine hydrochloride [826-39-1]; Down 200; 19.6uM; MCF7; HT_HG-U133A

RABGAP1 ENO2 CDK10 HDLBP

1.98e-041953443525_DN
DrugDioxybenzone [131-53-3]; Down 200; 16.4uM; HL60; HT_HG-U133A

PRKCSH ULK1 CDK10 VEGFA

2.02e-041963443101_DN
DrugScoulerine [6451-73-6]; Up 200; 12.2uM; PC3; HT_HG-U133A

RABGAP1 CLTCL1 DNAJA1 ARHGEF10

2.02e-041963445111_UP
DrugMephenesin [59-47-2]; Up 200; 22uM; PC3; HT_HG-U133A

RABGAP1 ARHGEF10 NR1H4 VEGFA

2.14e-041993447374_UP
DrugAC1L1BEH

NR1H4 JCHAIN MIB1

2.14e-0478343CID000001404
Drugradicicol

CDC37 DNAJA1 ENO2 VEGFA

2.31e-04203344CID000005033
DrugTrileucine

CLTCL1 CLTC

2.56e-0416342CID000082546
DrugVAL-TYR

ULK1 AGPS

2.56e-0416342CID004065033
DrugPE-W

CLTCL1 CLTC

2.56e-0416342CID016040251
Diseaseprimary biliary cholangitis (is_marker_for)

NR1H4 VEGFA

3.58e-0425332DOID:12236 (is_marker_for)
Diseaserefractive error

ZNF462 METAP1D AGPS NYAP1

4.65e-04326334MONDO_0004892
Diseaseserum gamma-glutamyl transferase measurement

ULK1 NR1H4 PLCE1 USP21 HDLBP VEGFA

4.70e-04914336EFO_0004532
DiseaseNon-Small Cell Lung Carcinoma

ZNF462 ENO2 VEGFA

7.04e-04156333C0007131
Diseasehypertension (is_marker_for)

ENO2 VEGFA

1.61e-0353332DOID:10763 (is_marker_for)
Diseasevascular endothelial growth factor measurement

ZNF462 VEGFA

1.80e-0356332EFO_0004762
DiseaseAtherogenesis

NR1H4 VEGFA

1.99e-0359332C1563937
DiseaseAtherosclerosis

NR1H4 VEGFA

1.99e-0359332C0004153
Diseasebody fat percentage

PPP1R21 METAP1D PLCE1 VEGFA

2.07e-03488334EFO_0007800
Diseasetriglycerides to total lipids in medium VLDL percentage

STIP1 VEGFA

2.27e-0363332EFO_0022335
Diseasecholesterol to total lipids in medium VLDL percentage

STIP1 VEGFA

2.27e-0363332EFO_0022239
Diseasecholesteryl esters to total lipids in medium VLDL percentage

STIP1 VEGFA

2.34e-0364332EFO_0022253
DiseaseNeoplasms, Experimental

ENO2 VEGFA

2.49e-0366332C0027659
Diseasetriglycerides to total lipids in very small VLDL percentage

STIP1 VEGFA

2.72e-0369332EFO_0022341
DiseaseBMI-adjusted waist-hip ratio, physical activity measurement

PLCE1 VEGFA

2.72e-0369332EFO_0007788, EFO_0008002

Protein segments in the cluster

PeptideGeneStartEntry
ILKKEDEIRAADCCR

ARHGEF10

796

O15013
VKACLRRKVCEQEEK

BARD1

636

Q99728
DRCKSCNGRKIVREK

DNAJA1

191

P31689
KRIERAVEEKACNCL

ENO2

326

P09104
CESLEQEARKKQRRC

TSPOAP1

351

O95153
RRKCQECRLRKCKEM

NR1H4

186

Q96RI1
KIRQKVDDCERCREF

RABGAP1

961

Q9Y3P9
ECGKKLVEVARRCRD

METAP1D

201

Q6UB28
IKCQVVKEIRCLGRK

CT45A10

126

P0DMU9
ICENTCKEKGRKERE

PRKCSH

111

P14314
KTSGEIIRCEKCKRE

DCLK3

131

Q9C098
IIRCEKCKRERELQQ

DCLK3

136

Q9C098
RNIREVKCRVVTCKT

MCM10

771

Q7L590
KECRLRTEECQLQLK

PPP1R21

191

Q6ZMI0
RVKKCLICKEQVQSR

MIB1

846

Q86YT6
CRKRKISSKDICQDR

FRG2C

96

A6NGY1
ERQICREKVGEKLCE

ATG101

136

Q9BSB4
KNVRVKERSRACLEC

IGSF22

426

Q8N9C0
LECEQIRLKCIRKEG

CDK10

6

Q15131
EKEELDRGCRECKRK

CDC37

46

Q16543
ECKRKVAECQRKLKE

CDC37

56

Q16543
ERIVLVDNKCKCARI

JCHAIN

26

P01591
CKREERICQKVIIKS

OTOGL

2261

Q3ZCN5
EVIERKRCVCKEIKA

NYAP1

781

Q6ZVC0
NKCRELCEKAIEVGR

STIP1

276

P31948
VRRFCKNDREVKKSV

PLCE1

326

Q9P212
CRNVKERITRECKEK

AGPS

541

O00116
CKTGQIKEVERICRE

CLTC

736

Q00610
CKTGQIKEVERICRE

CLTCL1

736

P53675
KCRLASRTDICEEKK

STK31

211

Q9BXU1
VCDRCRQKTRSTKKL

USP21

436

Q9UK80
LCTNCRKVLRKDKRI

SESN3

16

P58005
ERDKTKLRALKCRQC

ZNF462

1256

Q96JM2
EILCEVCRKTFKRKD

GTF3A

216

Q92664
RRCDIIIISGRKEKC

HDLBP

946

Q00341
NKCECRPKKDRARQE

VEGFA

126

P15692
DIENVTKCKLCIERR

ULK1

1026

O75385