Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionallyl-alcohol dehydrogenase activity

AKR1B10 AKR1B15 AKR1B1

7.46e-084543GO:0047655
GeneOntologyMolecularFunctionI-SMAD binding

SMAD1 SMAD2 SMAD3 SMAD5

1.11e-0717544GO:0070411
GeneOntologyMolecularFunctionDEAD/H-box RNA helicase binding

SMAD1 SMAD3 SMAD5

1.55e-069543GO:0017151
GeneOntologyMolecularFunctionmedium-chain fatty acid-CoA ligase activity

ACSF2 ACSM2A ACSM2B

3.04e-0611543GO:0031956
GeneOntologyMolecularFunctionco-SMAD binding

SMAD1 SMAD2 SMAD3

4.04e-0612543GO:0070410
GeneOntologyMolecularFunctionretinal dehydrogenase activity

AKR1B10 AKR1B15 AKR1B1

6.66e-0614543GO:0001758
GeneOntologyMolecularFunctionaldose reductase (NADPH) activity

AKR1B10 AKR1B15 AKR1B1

6.66e-0614543GO:0004032
GeneOntologyMolecularFunctionligase activity

LARS1 HARS1 MTHFS ACSF2 ACSM2A ACSM2B

7.33e-06174546GO:0016874
GeneOntologyMolecularFunctionall-trans-retinol dehydrogenase (NADP+) activity

AKR1B10 AKR1B15 AKR1B1

8.31e-0615543GO:0052650
GeneOntologyMolecularFunctionbenzoate-CoA ligase activity

ACSM2A ACSM2B

2.15e-053542GO:0018858
GeneOntologyMolecularFunctionindanol dehydrogenase activity

AKR1B10 AKR1B15

4.29e-054542GO:0047718
GeneOntologyMolecularFunctiondecanoate-CoA ligase activity

ACSM2A ACSM2B

4.29e-054542GO:0102391
GeneOntologyMolecularFunctionfatty acid ligase activity

ACSF2 ACSM2A ACSM2B

4.65e-0526543GO:0015645
GeneOntologyMolecularFunctionCoA-ligase activity

ACSF2 ACSM2A ACSM2B

5.22e-0527543GO:0016405
GeneOntologyMolecularFunctionalcohol dehydrogenase (NADP+) activity

AKR1B10 AKR1B15 AKR1B1

5.22e-0527543GO:0008106
GeneOntologyMolecularFunctionacid-thiol ligase activity

ACSF2 ACSM2A ACSM2B

7.96e-0531543GO:0016878
GeneOntologyMolecularFunctionSMAD binding

SMAD1 SMAD2 SMAD3 SMAD5

8.61e-0586544GO:0046332
GeneOntologyMolecularFunctionaldo-keto reductase (NADPH) activity

AKR1B10 AKR1B15 AKR1B1

8.77e-0532543GO:0004033
GeneOntologyMolecularFunctiongeranylgeranyl reductase activity

AKR1B10 AKR1B15

1.07e-046542GO:0045550
GeneOntologyMolecularFunctionligase activity, forming carbon-sulfur bonds

ACSF2 ACSM2A ACSM2B

1.85e-0441543GO:0016877
GeneOntologyMolecularFunctionfatty-acyl-CoA synthase activity

ACSM2A ACSM2B

1.99e-048542GO:0004321
GeneOntologyMolecularFunctionNADP+ binding

AKR1B10 AKR1B15

2.55e-049542GO:0070401
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

AKR1B10 AKR1B15 AKR1B1

2.97e-0448543GO:0016620
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the aldehyde or oxo group of donors

AKR1B10 AKR1B15 AKR1B1

4.68e-0456543GO:0016903
GeneOntologyMolecularFunctionestradiol 17-beta-dehydrogenase [NAD(P)+] activity

AKR1B10 AKR1B15

1.32e-0320542GO:0004303
GeneOntologyMolecularFunctionC-acyltransferase activity

ACSM2A ACSM2B

1.46e-0321542GO:0016408
GeneOntologyMolecularFunctionretinal binding

AKR1B10 AKR1B15

1.46e-0321542GO:0016918
GeneOntologyMolecularFunctionNADPH binding

AKR1B10 AKR1B15

2.24e-0326542GO:0070402
GeneOntologyMolecularFunctionR-SMAD binding

SMAD2 SMAD3

2.24e-0326542GO:0070412
GeneOntologyMolecularFunctiontransforming growth factor beta receptor binding

SMAD2 SMAD3

3.17e-0331542GO:0005160
GeneOntologyMolecularFunctionsteroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

AKR1B10 AKR1B15

3.59e-0333542GO:0033764
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

AKR1B10 AKR1B15 AKR1B1

4.92e-03127543GO:0016616
GeneOntologyMolecularFunctionsteroid dehydrogenase activity

AKR1B10 AKR1B15

4.99e-0339542GO:0016229
GeneOntologyMolecularFunctionligase activity, forming carbon-oxygen bonds

LARS1 HARS1

5.77e-0342542GO:0016875
GeneOntologyMolecularFunctionaminoacyl-tRNA ligase activity

LARS1 HARS1

5.77e-0342542GO:0004812
GeneOntologyMolecularFunctionoxidoreductase activity, acting on CH-OH group of donors

AKR1B10 AKR1B15 AKR1B1

6.19e-03138543GO:0016614
GeneOntologyMolecularFunctiontau protein binding

DCTN1 SMAD2

6.88e-0346542GO:0048156
GeneOntologyMolecularFunctioncatalytic activity, acting on a tRNA

LARS1 HARS1 TRMT2B

6.96e-03144543GO:0140101
GeneOntologyMolecularFunctionacetylglucosaminyltransferase activity

GCNT7 B3GNT5

7.18e-0347542GO:0008375
GeneOntologyMolecularFunctionretinoid binding

AKR1B10 AKR1B15

7.48e-0348542GO:0005501
GeneOntologyMolecularFunctionphosphatidylinositol-3,4,5-trisphosphate binding

BTK ARAP2

7.78e-0349542GO:0005547
GeneOntologyMolecularFunctionisoprenoid binding

AKR1B10 AKR1B15

7.78e-0349542GO:0019840
GeneOntologyMolecularFunctionvitamin binding

AKR1B10 AKR1B15 MTHFS

9.45e-03161543GO:0019842
GeneOntologyBiologicalProcessprimary miRNA processing

SMAD1 SMAD2 SMAD3

1.77e-0520533GO:0031053
GeneOntologyBiologicalProcessembryonic pattern specification

SMAD1 SMAD2 SMAD3 SMAD5

8.80e-0591534GO:0009880
GeneOntologyBiologicalProcessosteoblast fate commitment

SMAD1 SMAD5

9.65e-056532GO:0002051
GeneOntologyBiologicalProcessureteric bud development

SMAD1 SMAD2 SMAD3 SMAD5

1.65e-04107534GO:0001657
GeneOntologyBiologicalProcesspositive regulation of type I hypersensitivity

FCER1A BTK

1.80e-048532GO:0001812
GeneOntologyBiologicalProcessmesonephric tubule development

SMAD1 SMAD2 SMAD3 SMAD5

1.83e-04110534GO:0072164
GeneOntologyBiologicalProcessmesonephric epithelium development

SMAD1 SMAD2 SMAD3 SMAD5

1.83e-04110534GO:0072163
GeneOntologyBiologicalProcessSMAD protein signal transduction

SMAD1 SMAD2 SMAD3 SMAD5

1.83e-04110534GO:0060395
GeneOntologyBiologicalProcessmesonephros development

SMAD1 SMAD2 SMAD3 SMAD5

2.03e-04113534GO:0001823
GeneOntologyBiologicalProcessregulation of type I hypersensitivity

FCER1A BTK

2.31e-049532GO:0001810
GeneOntologyBiologicalProcessdaunorubicin metabolic process

AKR1B10 AKR1B1

2.31e-049532GO:0044597
GeneOntologyBiologicalProcessmiRNA processing

SMAD1 SMAD2 SMAD3

2.55e-0448533GO:0035196
GeneOntologyBiologicalProcesstype I hypersensitivity

FCER1A BTK

2.88e-0410532GO:0016068
GeneOntologyBiologicalProcessdoxorubicin metabolic process

AKR1B10 AKR1B1

2.88e-0410532GO:0044598
GeneOntologyBiologicalProcesspolyketide metabolic process

AKR1B10 AKR1B1

2.88e-0410532GO:0030638
GeneOntologyBiologicalProcessaminoglycoside antibiotic metabolic process

AKR1B10 AKR1B1

2.88e-0410532GO:0030647
GeneOntologyBiologicalProcessretinol metabolic process

AKR1B10 AKR1B15 AKR1B1

3.43e-0453533GO:0042572
GeneOntologyBiologicalProcessembryonic foregut morphogenesis

SMAD2 SMAD3

3.51e-0411532GO:0048617
GeneOntologyBiologicalProcessforegut morphogenesis

SMAD2 SMAD3

4.21e-0412532GO:0007440
GeneOntologyBiologicalProcessparaxial mesoderm morphogenesis

SMAD2 SMAD3

4.96e-0413532GO:0048340
GeneOntologyCellularComponentheteromeric SMAD protein complex

SMAD1 SMAD2 SMAD3 SMAD5

2.76e-098544GO:0071144
GeneOntologyCellularComponentSMAD protein complex

SMAD1 SMAD2 SMAD3 SMAD5

8.25e-0910544GO:0071141
GeneOntologyCellularComponenthomomeric SMAD protein complex

SMAD1 SMAD2

6.55e-062542GO:0071142
GeneOntologyCellularComponentmitochondrial matrix

AKR1B15 NIPSNAP2 MTHFS ACSF2 ACSM2A TRMT2B ACSM2B

3.77e-04523547GO:0005759
HumanPhenoLong fingers

TRIO LARS1 MTHFS CNOT1 CCNK SMAD2 SMAD3

1.88e-05306167HP:0100807
DomainDwarfin

SMAD1 SMAD2 SMAD3 SMAD5

4.33e-098544IPR013790
DomainDWB

SMAD1 SMAD2 SMAD3 SMAD5

4.33e-098544SM00524
Domain-

SMAD1 SMAD2 SMAD3 SMAD5

4.33e-0985443.90.520.10
DomainMAD_homology_MH1

SMAD1 SMAD2 SMAD3 SMAD5

4.33e-098544IPR013019
DomainMH2

SMAD1 SMAD2 SMAD3 SMAD5

4.33e-098544PS51076
DomainMH1

SMAD1 SMAD2 SMAD3 SMAD5

4.33e-098544PS51075
DomainMH2

SMAD1 SMAD2 SMAD3 SMAD5

4.33e-098544PF03166
DomainSMAD_dom_Dwarfin-type

SMAD1 SMAD2 SMAD3 SMAD5

4.33e-098544IPR001132
DomainMAD_homology1_Dwarfin-type

SMAD1 SMAD2 SMAD3 SMAD5

3.04e-0812544IPR003619
DomainDWA

SMAD1 SMAD2 SMAD3 SMAD5

3.04e-0812544SM00523
DomainMH1

SMAD1 SMAD2 SMAD3 SMAD5

3.04e-0812544PF03165
DomainSMAD_dom-like

SMAD1 SMAD2 SMAD3 SMAD5

1.11e-0716544IPR017855
Domain-

SMAD1 SMAD2 SMAD3 SMAD5

1.11e-07165442.60.200.10
DomainALDOKETO_REDUCTASE_1

AKR1B10 AKR1B15 AKR1B1

2.70e-0610543PS00798
DomainAldo/ket_reductase_CS

AKR1B10 AKR1B15 AKR1B1

2.70e-0610543IPR018170
DomainAldo/keto_reductase

AKR1B10 AKR1B15 AKR1B1

2.70e-0610543IPR020471
DomainALDOKETO_REDUCTASE_2

AKR1B10 AKR1B15 AKR1B1

2.70e-0610543PS00062
DomainALDOKETO_REDUCTASE_3

AKR1B10 AKR1B15 AKR1B1

2.70e-0610543PS00063
Domain-

AKR1B10 AKR1B15 AKR1B1

1.25e-05165433.20.20.100
DomainNADP_OxRdtase_dom

AKR1B10 AKR1B15 AKR1B1

1.51e-0517543IPR023210
DomainAldo_ket_red

AKR1B10 AKR1B15 AKR1B1

1.51e-0517543PF00248
DomainAldo/ket_red/Kv-b

AKR1B10 AKR1B15 AKR1B1

1.51e-0517543IPR001395
DomainAMP-bd_C

ACSF2 ACSM2A ACSM2B

1.51e-0517543IPR025110
DomainAMP-binding_C

ACSF2 ACSM2A ACSM2B

1.51e-0517543PF13193
DomainSMAD_FHA_domain

SMAD1 SMAD2 SMAD3 SMAD5

1.52e-0552544IPR008984
DomainAMP-binding_CS

ACSF2 ACSM2A ACSM2B

5.67e-0526543IPR020845
DomainAMP_BINDING

ACSF2 ACSM2A ACSM2B

7.11e-0528543PS00455
DomainAMP-binding

ACSF2 ACSM2A ACSM2B

8.78e-0530543PF00501
DomainAMP-dep_Synth/Lig

ACSF2 ACSM2A ACSM2B

8.78e-0530543IPR000873
DomainRA

MYO9A APBB1IP ARAP2

1.52e-0436543PF00788
DomainRA

MYO9A APBB1IP ARAP2

1.66e-0437543PS50200
DomainRA_dom

MYO9A APBB1IP ARAP2

2.09e-0440543IPR000159
DomainRA

MYO9A APBB1IP

3.62e-0331542SM00314
DomainPH

TRIO BTK APBB1IP ARAP2

4.31e-03229544PF00169
DomainPH

TRIO BTK APBB1IP ARAP2

8.48e-03278544SM00233
DomainPH_DOMAIN

TRIO BTK APBB1IP ARAP2

8.58e-03279544PS50003
PathwayWP_NEOVASCULARIZATION_PROCESSES

SMAD1 SMAD2 SMAD3 SMAD5

5.54e-0637454M39506
PathwayWP_TGFBETA_SIGNALING_PATHWAY

SMAD1 SMAD2 SMAD3 SMAD5

2.37e-0553454MM15880
PathwayWP_TGFBETA_RECEPTOR_SIGNALING

SMAD1 SMAD2 SMAD3 SMAD5

2.74e-0555454M39351
PathwayREACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS

CCNK SMAD1 SMAD2 SMAD3 SMAD5

3.53e-05118455MM15588
PathwayWP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS

SMAD1 SMAD2 SMAD3 SMAD5

3.63e-0559454M39886
PathwayREACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION

CCNK SMAD2 SMAD3

7.51e-0526453MM14878
PathwayREACTOME_CONJUGATION_OF_SALICYLATE_WITH_GLYCINE

ACSM2A ACSM2B

1.48e-046452MM14693
PathwayREACTOME_SIGNALING_BY_NODAL

SMAD2 SMAD3

1.48e-046452MM14517
PathwayREACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS

CCNK SMAD1 SMAD2 SMAD3 SMAD5

1.54e-04161455M27871
PathwayKEGG_TGF_BETA_SIGNALING_PATHWAY

SMAD1 SMAD2 SMAD3 SMAD5

1.59e-0486454M2642
PathwayREACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION

CCNK SMAD2 SMAD3

2.02e-0436453M633
PathwayREACTOME_LOSS_OF_FUNCTION_OF_SMAD2_3_IN_CANCER

SMAD2 SMAD3

2.07e-047452M29623
PathwayREACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES

SMAD2 SMAD3

2.07e-047452MM15661
PathwayREACTOME_AMINO_ACID_CONJUGATION

ACSM2A ACSM2B

2.07e-047452MM14598
PathwayKEGG_MEDICUS_REFERENCE_BMP15_SIGNALING_PATHWAY

SMAD1 SMAD5

2.07e-047452M47845
PathwayREACTOME_ESTROGEN_BIOSYNTHESIS

AKR1B10 AKR1B15

2.07e-047452MM14740
PathwayREACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX_IN_CANCER

SMAD2 SMAD3

2.76e-048452M27246
PathwayKEGG_MEDICUS_REFERENCE_TGF_BETA_SIGNALING_PATHWAY

SMAD2 SMAD3

2.76e-048452M47415
PathwayKEGG_MEDICUS_REFERENCE_NODAL_SIGNALING_PATHWAY

SMAD2 SMAD3

2.76e-048452M47849
PathwayKEGG_MEDICUS_REFERENCE_ACTIVIN_SIGNALING_PATHWAY

SMAD2 SMAD3

2.76e-048452M47846
PathwayKEGG_MEDICUS_REFERENCE_MYOSTATIN_SIGNALING_PATHWAY

SMAD1 SMAD5

2.76e-048452M47847
PathwayREACTOME_METABOLISM_OF_STEROID_HORMONES

AKR1B10 AKR1B15 AKR1B1

2.98e-0441453MM14757
PathwayREACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER

CCNK SMAD2 SMAD3

2.98e-0441453MM14876
PathwayKEGG_MEDICUS_REFERENCE_AMH_SIGNALING_PATHWAY

SMAD1 SMAD5

3.54e-049452M47844
PathwayKEGG_MEDICUS_REFERENCE_BMP9_10_SIGNALING_PATHWAY

SMAD1 SMAD5

3.54e-049452M47822
PathwayREACTOME_AMINO_ACID_CONJUGATION

ACSM2A ACSM2B

3.54e-049452M26968
PathwayWP_MACROPHAGESTIMULATING_PROTEIN_MSP_SIGNALING

SMAD1 SMAD2 SMAD3 SMAD5

3.81e-04108454M48078
PathwayWP_ID_SIGNALING_PATHWAY

SMAD1 SMAD3 SMAD5

5.36e-0450453MM15817
PathwayPID_ALK2_PATHWAY

SMAD1 SMAD5

5.38e-0411452M203
PathwayKEGG_MEDICUS_REFERENCE_BMP_HAMP_SIGNALING_PATHWAY

SMAD1 SMAD5

5.38e-0411452M47848
PathwayREACTOME_TRANSCRIPTIONAL_ACTIVITY_OF_SMAD2_SMAD3_SMAD4_HETEROTRIMER

CCNK SMAD2 SMAD3

5.69e-0451453M665
PathwayWP_TGFB_SMAD_SIGNALING

SMAD2 SMAD3

6.44e-0412452M48091
PathwayWP_BMP2WNT4FOXO1_PATHWAY_IN_PRIMARY_ENDOMETRIAL_STROMAL_CELL_DIFFERENTIATION

SMAD1 SMAD5

7.60e-0413452M39378
PathwayREACTOME_LYSOSPHINGOLIPID_AND_LPA_RECEPTORS

PLPPR4 S1PR2

8.85e-0414452M27331
PathwayREACTOME_LYSOSPHINGOLIPID_AND_LPA_RECEPTORS

PLPPR4 S1PR2

8.85e-0414452MM15062
PathwayREACTOME_FORMATION_OF_AXIAL_MESODERM

SMAD2 SMAD3

8.85e-0414452M46441
PathwayREACTOME_SIGNALING_BY_ACTIVIN

SMAD2 SMAD3

1.02e-0315452MM14593
PathwayREACTOME_RHOA_GTPASE_CYCLE

TRIO MYO9A HMOX2 ARAP2

1.07e-03142454MM15576
PathwayPID_SMAD2_3PATHWAY

SMAD2 SMAD3

1.16e-0316452M228
PathwayREACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING

SMAD2 SMAD3

1.16e-0316452MM14873
PathwayREACTOME_RHOA_GTPASE_CYCLE

TRIO MYO9A HMOX2 ARAP2

1.28e-03149454M41805
PathwayREACTOME_GERM_LAYER_FORMATION_AT_GASTRULATION

SMAD2 SMAD3

1.31e-0317452M45017
PathwayWP_CANONICAL_AND_NONCANONICAL_TGFB_SIGNALING

SMAD2 SMAD3

1.31e-0317452M39686
PathwayBIOCARTA_TGFB_PATHWAY

SMAD2 SMAD3

1.31e-0317452MM1509
PathwayREACTOME_FORMATION_OF_DEFINITIVE_ENDODERM

SMAD2 SMAD3

1.31e-0317452M48030
PathwayREACTOME_SIGNALING_BY_ACTIVIN

SMAD2 SMAD3

1.31e-0317452M26965
PathwayREACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_CELL_CYCLE_GENES

SMAD2 SMAD3

1.31e-0317452M27946
PathwayREACTOME_TP53_REGULATES_TRANSCRIPTION_OF_ADDITIONAL_CELL_CYCLE_GENES_WHOSE_EXACT_ROLE_IN_THE_P53_PATHWAY_REMAIN_UNCERTAIN

CNOT1 PLK3

1.48e-0318452MM15336
PathwayWP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION

SMAD2 SMAD3

1.65e-0319452M39370
PathwayBIOCARTA_TGFB_PATHWAY

SMAD2 SMAD3

1.65e-0319452M18933
PathwayWP_HYPOXIADEPENDENT_PROLIFERATION_OF_MYOBLASTS

SMAD2 SMAD3

1.65e-0319452MM15811
PathwayWP_BMP_SIGNALING_PATHWAY_IN_EYELID_DEVELOPMENT

SMAD1 SMAD5

1.83e-0320452MM15907
PathwayWP_BMP_SIGNALING_IN_EYELID_DEVELOPMENT

SMAD1 SMAD5

1.83e-0320452M39624
PathwayKEGG_MEDICUS_REFERENCE_BMP_SIGNALING_PATHWAY

SMAD1 SMAD5

1.83e-0320452M47843
PathwayREACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX

CCNK SMAD2 SMAD3

1.89e-0377453MM14670
PathwayREACTOME_TP53_REGULATES_TRANSCRIPTION_OF_ADDITIONAL_CELL_CYCLE_GENES_WHOSE_EXACT_ROLE_IN_THE_P53_PATHWAY_REMAIN_UNCERTAIN

CNOT1 PLK3

2.01e-0321452M27634
PathwayWP_PROGERIAASSOCIATED_LIPODYSTROPHY

SMAD2 SMAD3

2.21e-0322452M42534
PathwayREACTOME_FOXO_MEDIATED_TRANSCRIPTION

SMAD2 SMAD3

2.21e-0322452MM15656
PathwayREACTOME_SIGNALING_BY_NODAL

SMAD2 SMAD3

2.42e-0323452M511
PathwayREACTOME_CYTOSOLIC_TRNA_AMINOACYLATION

LARS1 HARS1

2.63e-0324452M6591
PathwayBIOCARTA_CTCF_PATHWAY

SMAD1 SMAD5

2.63e-0324452M11420
PathwayREACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY

SMAD2 SMAD3

2.63e-0324452MM14877
PathwayBIOCARTA_CTCF_PATHWAY

SMAD1 SMAD5

2.63e-0324452MM1373
PathwayREACTOME_GENERIC_TRANSCRIPTION_PATHWAY

ZFP30 PRMT5 CNOT1 CCNK PLK3 SMAD1 SMAD2 SMAD3

2.68e-03768458MM14851
PathwayWP_DIFFERENTIATION_OF_WHITE_AND_BROWN_ADIPOCYTE

SMAD1 SMAD5

2.85e-0325452M39665
PathwayWP_HYPOTHESIZED_PATHWAYS_IN_PATHOGENESIS_OF_CARDIOVASCULAR_DISEASE

SMAD2 SMAD3

2.85e-0325452M39713
PathwayPID_ALK1_PATHWAY

SMAD1 SMAD5

3.08e-0326452M185
PathwayREACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING

SMAD2 SMAD3

3.08e-0326452M628
PathwayREACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX

CCNK SMAD2 SMAD3

3.33e-0394453M1041
PathwayWP_EXTRACELLULAR_VESICLEMEDIATED_SIGNALING_IN_RECIPIENT_CELLS

SMAD2 SMAD3

3.83e-0329452M39516
PathwayKEGG_MEDICUS_REFERENCE_DYNEIN_RECRUITMENT_TO_THE_KINETOCHORE

ZWILCH DCTN1

4.09e-0330452M47889
PathwayREACTOME_FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES

SMAD2 SMAD3

4.09e-0330452M27941
PathwayREACTOME_SIGNALING_BY_RHO_GTPASES_MIRO_GTPASES_AND_RHOBTB3

ZWILCH TRIO MYO9A BTK NIPSNAP2 HMOX2 ARAP2

4.19e-03649457MM15690
PathwayREACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY

SMAD2 SMAD3

4.37e-0331452M669
PathwayWP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING

SMAD2 SMAD3

4.37e-0331452MM15818
PathwayREACTOME_SIGNALING_BY_BMP

SMAD1 SMAD5

4.37e-0331452M1662
PathwayREACTOME_SIGNALING_BY_BMP

SMAD1 SMAD5

4.37e-0331452MM14789
PathwayREACTOME_O_LINKED_GLYCOSYLATION

GCNT7 THSD7A B3GNT5

5.04e-03109453MM15164
PathwayKEGG_FRUCTOSE_AND_MANNOSE_METABOLISM

AKR1B10 AKR1B1

5.24e-0334452M15898
PathwayKEGG_BUTANOATE_METABOLISM

AKR1B10 ACSM2A

5.24e-0334452M3397
PathwayREACTOME_TP53_REGULATES_TRANSCRIPTION_OF_CELL_CYCLE_GENES

CNOT1 PLK3

5.24e-0334452MM15325
PathwayREACTOME_O_LINKED_GLYCOSYLATION

GCNT7 THSD7A B3GNT5

5.30e-03111453M27416
PathwayWP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING

SMAD2 SMAD3

5.86e-0336452M39569
PathwayREACTOME_METABOLISM_OF_STEROID_HORMONES

AKR1B15 AKR1B1

5.86e-0336452M27081
PathwayBIOCARTA_ALK_PATHWAY

SMAD1 SMAD5

6.18e-0337452M17400
PathwayREACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS

SMAD2 SMAD3

6.51e-0338452MM14874
Pubmed

The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines.

SMAD1 SMAD2 SMAD3 SMAD5

2.79e-11555415647271
Pubmed

Smad1-Smad5 ovarian conditional knockout mice develop a disease profile similar to the juvenile form of human granulosa cell tumors.

SMAD1 SMAD2 SMAD3 SMAD5

2.79e-11555419819941
Pubmed

Brightfield proximity ligation assay reveals both canonical and mixed transforming growth factor-β/bone morphogenetic protein Smad signaling complexes in tissue sections.

SMAD1 SMAD2 SMAD3 SMAD5

2.79e-11555425141865
Pubmed

Mad-related genes in the human.

SMAD1 SMAD2 SMAD3 SMAD5

2.79e-1155548673135
Pubmed

Smad7 is required for the development and function of the heart.

SMAD1 SMAD2 SMAD3 SMAD5

8.37e-11655418952608
Pubmed

Control of early fate decisions in human ES cells by distinct states of TGFbeta pathway activity.

SMAD1 SMAD2 SMAD3 SMAD5

8.37e-11655418393632
Pubmed

Immunohistochemical expression of Smads 1-6 in the 15-day gestation mouse embryo: signaling by BMPs and TGF-betas.

SMAD1 SMAD2 SMAD3 SMAD5

8.37e-11655411169847
Pubmed

Dynamic regulation of Smad expression during mesenchyme to epithelium transition in the metanephric kidney.

SMAD1 SMAD2 SMAD3 SMAD5

8.37e-11655411850197
Pubmed

SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes.

SMAD1 SMAD2 SMAD3 SMAD5

8.37e-11655410400677
Pubmed

Regulation of transforming growth factor-beta and bone morphogenetic protein signalling by transcriptional coactivator GCN5.

SMAD1 SMAD2 SMAD3 SMAD5

1.95e-10755415009097
Pubmed

Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1.

SMAD1 SMAD2 SMAD3 SMAD5

1.95e-10755412370310
Pubmed

Interaction with Smad4 is indispensable for suppression of BMP signaling by c-Ski.

SMAD1 SMAD2 SMAD3 SMAD5

1.95e-10755414699069
Pubmed

Can't get no SMADisfaction: Smad proteins as positive and negative regulators of TGF-beta family signals.

SMAD1 SMAD2 SMAD3 SMAD5

1.95e-10755410376010
Pubmed

Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling.

SMAD1 SMAD2 SMAD3 SMAD5

1.95e-10755414580334
Pubmed

Pkd1 is required for male reproductive tract development.

SMAD1 SMAD2 SMAD3 SMAD5

1.95e-10755423933588
Pubmed

Negative regulation of BMP/Smad signaling by Tob in osteoblasts.

SMAD1 SMAD2 SMAD3 SMAD5

1.95e-10755411163184
Pubmed

A new nonsense mutation of SMAD8 associated with pulmonary arterial hypertension.

SMAD1 SMAD2 SMAD3 SMAD5

3.90e-10855419211612
Pubmed

Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter.

SMAD1 SMAD2 SMAD3 SMAD5

3.90e-10855410531362
Pubmed

Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells.

SMAD1 SMAD2 SMAD3 SMAD5

3.90e-10855410647776
Pubmed

Computational modelling of Smad-mediated negative feedback and crosstalk in the TGF-β superfamily network.

SMAD1 SMAD2 SMAD3 SMAD5

3.90e-10855423804438
Pubmed

Interaction between Smad-interacting protein-1 and the corepressor C-terminal binding protein is dispensable for transcriptional repression of E-cadherin.

SMAD1 SMAD2 SMAD3 SMAD5

3.90e-10855412714599
Pubmed

TGF-beta signaling by Smad proteins.

SMAD1 SMAD2 SMAD3 SMAD5

3.90e-10855410708949
Pubmed

Holding their own: the noncanonical roles of Smad proteins.

SMAD1 SMAD2 SMAD3 SMAD5

7.01e-10955419018011
Pubmed

GATA4 is essential for bone mineralization via ERα and TGFβ/BMP pathways.

SMAD1 SMAD2 SMAD3 SMAD5

7.01e-10955424932701
Pubmed

TGF-beta signal transduction.

SMAD1 SMAD2 SMAD3 SMAD5

7.01e-1095549759503
Pubmed

Combinatorial Smad2/3 Activities Downstream of Nodal Signaling Maintain Embryonic/Extra-Embryonic Cell Identities during Lineage Priming.

SMAD1 SMAD2 SMAD3 SMAD5

7.01e-10955430134160
Pubmed

Interactions between BMP-7 and USAG-1 (uterine sensitization-associated gene-1) regulate supernumerary organ formations.

SMAD1 SMAD2 SMAD3 SMAD5

7.01e-10955424816837
Pubmed

Dullard/Ctdnep1 regulates endochondral ossification via suppression of TGF-β signaling.

SMAD1 SMAD2 SMAD3 SMAD5

7.01e-10955425155999
Pubmed

The Smad pathway.

SMAD1 SMAD2 SMAD3 SMAD5

7.01e-10955410708948
Pubmed

Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1).

SMAD1 SMAD2 SMAD3 SMAD5

1.17e-091055415221015
Pubmed

Protein Arginine Methyltransferase PRMT1 Is Essential for Palatogenesis.

SMAD1 SMAD2 SMAD3 SMAD5

1.17e-091055429986157
Pubmed

TGF-β signaling inhibits canonical BMP signaling pathway during palate development.

SMAD1 SMAD2 SMAD3 SMAD5

1.17e-091055429247325
Pubmed

Spatio-temporal distribution of Smads and role of Smads/TGF-β/BMP-4 in the regulation of mouse bladder organogenesis.

SMAD1 SMAD2 SMAD3 SMAD5

1.17e-091055423620745
Pubmed

Disruption of transforming growth factor-beta signaling in ELF beta-spectrin-deficient mice.

SMAD1 SMAD2 SMAD3 SMAD5

1.17e-091055412543979
Pubmed

Smad2 and Smad3 Regulate Chondrocyte Proliferation and Differentiation in the Growth Plate.

SMAD1 SMAD2 SMAD3 SMAD5

1.83e-091155427741240
Pubmed

Downregulation of bone morphogenetic protein receptor axis during HIV-1 and cocaine-mediated pulmonary smooth muscle hyperplasia: implications for HIV-related pulmonary arterial hypertension.

SMAD1 SMAD2 SMAD3 SMAD5

1.83e-091155424008158
Pubmed

BMPR-II is dispensable for formation of the limb skeleton.

SMAD1 SMAD2 SMAD3 SMAD5

2.74e-091255421538804
Pubmed

Crim1KST264/KST264 mice implicate Crim1 in the regulation of vascular endothelial growth factor-A activity during glomerular vascular development.

SMAD1 SMAD2 SMAD3 SMAD5

2.74e-091255417460146
Pubmed

Smad expression during kidney development.

SMAD1 SMAD2 SMAD3 SMAD5

2.74e-091255414656760
Pubmed

Substrate specificity and catalytic efficiency of aldo-keto reductases with phospholipid aldehydes.

AKR1B10 AKR1B15 AKR1B1

3.74e-09355317381426
Pubmed

Blockade of Smad signaling by 3'-deoxyadenosine: a mechanism for its anti-fibrotic potential.

SMAD1 SMAD2 SMAD3

3.74e-09355323439432
Pubmed

Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways.

SMAD1 SMAD2 SMAD3 SMAD5

3.96e-091355419914168
Pubmed

Essential functions of Alk3 during AV cushion morphogenesis in mouse embryonic hearts.

SMAD1 SMAD2 SMAD3 SMAD5

3.96e-091355416959237
Pubmed

Enhanced BMP signaling results in supernumerary tooth formation in USAG-1 deficient mouse.

SMAD1 SMAD2 SMAD3 SMAD5

3.96e-091355418329379
Pubmed

Endoglin is required for myogenic differentiation potential of neural crest stem cells.

SMAD1 SMAD2 SMAD3 SMAD5

3.96e-091355417628518
Pubmed

Matrix GLA protein, an inhibitory morphogen in pulmonary vascular development.

SMAD1 SMAD2 SMAD3 SMAD5

5.54e-091455417670744
Pubmed

The chromatin regulator Ankrd11 controls cardiac neural crest cell-mediated outflow tract remodeling and heart function.

SMAD1 SMAD2 SMAD3 SMAD5

5.54e-091455438951500
Pubmed

An atypical canonical bone morphogenetic protein (BMP) signaling pathway regulates Msh homeobox 1 (Msx1) expression during odontogenesis.

SMAD1 SMAD2 SMAD3 SMAD5

5.54e-091455425274628
Pubmed

Loss of Smad4 in the scleraxis cell lineage results in postnatal joint contracture.

SMAD1 SMAD2 SMAD3 SMAD5

5.54e-091455433248111
Pubmed

The function of growth/differentiation factor 11 (Gdf11) in rostrocaudal patterning of the developing spinal cord.

SMAD1 SMAD2 SMAD3 SMAD5

5.54e-091455416790475
Pubmed

Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus.

SMAD1 SMAD2 SMAD3 SMAD5

5.54e-091455416435884
Pubmed

SMAD proteins control DROSHA-mediated microRNA maturation.

SMAD1 SMAD2 SMAD3 SMAD5

7.54e-091555418548003
Pubmed

Tbx1 genetically interacts with the transforming growth factor-β/bone morphogenetic protein inhibitor Smad7 during great vessel remodeling.

SMAD1 SMAD2 SMAD3 SMAD5

7.54e-091555423011393
Pubmed

Epicardial calcineurin-NFAT signals through Smad2 to direct coronary smooth muscle cell and arterial wall development.

SMAD1 SMAD2 SMAD3 SMAD5

7.54e-091555423946498
Pubmed

Spatial and temporal expression of molecular markers and cell signals during normal development of the mouse patellar tendon.

SMAD1 SMAD2 SMAD3 SMAD5

1.00e-081655421939397
Pubmed

Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4.

SMAD1 SMAD2 SMAD3

1.50e-0845539111321
Pubmed

Investigation of DNA polymorphisms in SMAD genes for genetic predisposition to diabetic nephropathy in patients with type 1 diabetes mellitus.

SMAD1 SMAD3 SMAD5

1.50e-08455319247629
Pubmed

Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling.

SMAD1 SMAD2 SMAD3

1.50e-08455311016919
Pubmed

Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling.

SMAD1 SMAD2 SMAD3

1.50e-08455317292623
Pubmed

Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers.

SMAD1 SMAD2 SMAD3

1.50e-08455321724602
Pubmed

A novel ability of Smad3 to regulate proteasomal degradation of a Cas family member HEF1.

SMAD1 SMAD2 SMAD3

1.50e-08455311118211
Pubmed

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase.

SMAD1 SMAD2 SMAD3

1.50e-08455311158580
Pubmed

Functions of mammalian Smad genes as revealed by targeted gene disruption in mice.

SMAD2 SMAD3 SMAD5

1.50e-08455310708952
Pubmed

TGF-β-activated kinase 1 (Tak1) mediates agonist-induced Smad activation and linker region phosphorylation in embryonic craniofacial neural crest-derived cells.

SMAD1 SMAD2 SMAD3 SMAD5

1.68e-081855423546880
Pubmed

Tbx2 and Tbx3 Act Downstream of Shh to Maintain Canonical Wnt Signaling during Branching Morphogenesis of the Murine Lung.

SMAD1 SMAD2 SMAD3 SMAD5

1.68e-081855427720610
Pubmed

Augmented BMPRIA-mediated BMP signaling in cranial neural crest lineage leads to cleft palate formation and delayed tooth differentiation.

SMAD1 SMAD2 SMAD3 SMAD5

2.13e-081955423776616
Pubmed

Fgf9 signaling regulates small intestinal elongation and mesenchymal development.

SMAD1 SMAD2 SMAD3 SMAD5

2.66e-082055418653563
Pubmed

RAB23 coordinates early osteogenesis by repressing FGF10-pERK1/2 and GLI1.

SMAD1 SMAD2 SMAD3 SMAD5

2.66e-082055432662771
Pubmed

Functions of the type 1 BMP receptor Acvr1 (Alk2) in lens development: cell proliferation, terminal differentiation, and survival.

SMAD1 SMAD2 SMAD5

3.73e-08555318566469
Pubmed

Carboxy-terminally truncated Gli3 proteins associate with Smads.

SMAD1 SMAD2 SMAD3

3.73e-0855539843199
Pubmed

Comparisons of genomic structures and chromosomal locations of the mouse aldose reductase and aldose reductase-like genes.

AKR1B10 AKR1B15 AKR1B1

3.73e-08555310092857
Pubmed

Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation.

SMAD1 SMAD2 SMAD3

3.73e-08555312808092
Pubmed

Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway.

SMAD1 SMAD2 SMAD3

3.73e-08555312743038
Pubmed

Sphingosine-1-phosphate/S1PR2-mediated signaling triggers Smad1/5/8 phosphorylation and thereby induces Runx2 expression in osteoblasts.

S1PR2 SMAD1 SMAD5

3.73e-08555327612439
Pubmed

Two short segments of Smad3 are important for specific interaction of Smad3 with c-Ski and SnoN.

SMAD1 SMAD2 SMAD3

3.73e-08555312426322
Pubmed

Functional cloning of the proto-oncogene brain factor-1 (BF-1) as a Smad-binding antagonist of transforming growth factor-beta signaling.

SMAD1 SMAD2 SMAD3

3.73e-08555311387330
Pubmed

E1A inhibits transforming growth factor-beta signaling through binding to Smad proteins.

SMAD1 SMAD2 SMAD3

3.73e-08555310497242
Pubmed

USP15 is a deubiquitylating enzyme for receptor-activated SMADs.

SMAD1 SMAD2 SMAD3

3.73e-08555321947082
Pubmed

The MH1 domain of Smad3 interacts with Pax6 and represses autoregulation of the Pax6 P1 promoter.

SMAD1 SMAD3 SMAD5

3.73e-08555317251190
Pubmed

Myocardial smad4 is essential for cardiogenesis in mouse embryos.

SMAD1 SMAD2 SMAD3 SMAD5

4.01e-082255417585069
Pubmed

Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development.

SMAD1 SMAD2 SMAD3 SMAD5

4.85e-082355421937600
Pubmed

Man1, an inner nuclear membrane protein, regulates vascular remodeling by modulating transforming growth factor beta signaling.

SMAD1 SMAD2 SMAD3 SMAD5

5.81e-082455416943282
Pubmed

Airway basal stem cells reutilize the embryonic proliferation regulator, Tgfβ-Id2 axis, for tissue regeneration.

SMAD1 SMAD2 SMAD3 SMAD5

5.81e-082455434129836
Pubmed

Neural crest cell-autonomous roles of fibronectin in cardiovascular development.

SMAD1 SMAD2 SMAD3 SMAD5

5.81e-082455426552887
Pubmed

Fibulin-4 deficiency results in ascending aortic aneurysms: a potential link between abnormal smooth muscle cell phenotype and aneurysm progression.

SMAD1 SMAD2 SMAD3 SMAD5

6.91e-082555420019329
Pubmed

TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3.

SMAD1 SMAD2 SMAD3

7.46e-08655311711431
Pubmed

Repression of Smad transcriptional activity by PIASy, an inhibitor of activated STAT.

SMAD1 SMAD2 SMAD3

7.46e-08655312904571
Pubmed

Structural basis for transcriptional coactivator recognition by SMAD2 in TGF-β signaling.

SMAD1 SMAD2 SMAD3

7.46e-08655333323411
Pubmed

FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination.

SMAD1 SMAD2 SMAD3

7.46e-08655319135894
Pubmed

Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.

SMAD1 SMAD2 SMAD3

7.46e-0865538774881
Pubmed

Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways.

SMAD1 SMAD2 SMAD3

7.46e-08655310890911
Pubmed

Regeneration of axons in injured spinal cord by activation of bone morphogenetic protein/Smad1 signaling pathway in adult neurons.

SMAD1 SMAD2 SMAD5

7.46e-08655321518886
Pubmed

Novel roles of Pkd2 in male reproductive system development.

SMAD1 SMAD2 SMAD5

7.46e-08655324951251
Pubmed

Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins.

SMAD1 SMAD2 SMAD3

7.46e-08655311160896
Pubmed

Genetic variation in the TGF-β signaling pathway and colon and rectal cancer risk.

SMAD1 SMAD2 SMAD3

7.46e-08655321068203
Pubmed

PRDM16/MEL1: a novel Smad binding protein expressed in murine embryonic orofacial tissue.

SMAD1 SMAD2 SMAD3

7.46e-08655317467076
Pubmed

Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1.

SMAD1 SMAD2 SMAD3

7.46e-08655315849193
Pubmed

The TGFβ type I receptor TGFβRI functions as an inhibitor of BMP signaling in cartilage.

SMAD1 SMAD2 SMAD3 SMAD5

8.15e-082655431311865
Pubmed

Loss of Sox9 in the periotic mesenchyme affects mesenchymal expansion and differentiation, and epithelial morphogenesis during cochlea development in the mouse.

SMAD1 SMAD2 SMAD3 SMAD5

1.11e-072855420346939
Pubmed

Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2.

SMAD1 SMAD3 SMAD5

1.30e-07755315150273
InteractionTOB1 interactions

CNOT1 SMAD1 SMAD2 SMAD3 SMAD5

1.26e-0744555int:TOB1
InteractionAKR1B15 interactions

AKR1B10 AKR1B15 AKR1B1

6.85e-0614553int:AKR1B15
InteractionRASL12 interactions

SMAD1 SMAD2 SMAD3

2.12e-0520553int:RASL12
InteractionRUNX3 interactions

SMAD1 SMAD2 SMAD3 SMAD5

2.31e-0561554int:RUNX3
InteractionHOXA13 interactions

SMAD1 SMAD2 SMAD5

2.86e-0522553int:HOXA13
InteractionZNF8 interactions

SMAD1 SMAD2 SMAD3 SMAD5

3.98e-0570554int:ZNF8
InteractionRASD2 interactions

SMAD1 SMAD2 SMAD3

4.24e-0525553int:RASD2
InteractionACSM2A interactions

ACSM2A ACSM2B

4.37e-054552int:ACSM2A
InteractionACSM2B interactions

ACSM2A ACSM2B

4.37e-054552int:ACSM2B
InteractionPSMD11 interactions

PRMT5 ZNF598 DCTN1 SMAD1 SMAD2 SMAD3 SMAD5

4.70e-05353557int:PSMD11
InteractionMBD1 interactions

PRMT5 SMAD1 SMAD3 SMAD5

5.79e-0577554int:MBD1
InteractionSKI interactions

PRMT5 SMAD1 SMAD2 SMAD3 SMAD5

7.48e-05160555int:SKI
InteractionSMC4 interactions

ZWILCH PRMT5 NEK7 HMOX2 ZNF598 DCTN1

1.14e-04281556int:SMC4
InteractionZEB2 interactions

SMAD1 SMAD2 SMAD3 SMAD5

1.31e-0495554int:ZEB2
InteractionGLI3 interactions

CNOT1 SMAD1 SMAD2 SMAD3

1.48e-0498554int:GLI3
InteractionRAB38 interactions

SMAD1 SMAD2 SMAD3

1.52e-0438553int:RAB38
InteractionGDF6 interactions

SMAD1 SMAD5

1.52e-047552int:GDF6
InteractionCOL3A1 interactions

SMAD1 SMAD2 SMAD3

1.64e-0439553int:COL3A1
InteractionSMAD5 interactions

SMAD1 SMAD2 SMAD3 SMAD5

1.67e-04101554int:SMAD5
InteractionMTA2 interactions

PRMT5 NIPSNAP2 ZNF598 DCTN1 LIN9 SMAD2 SMAD3

1.73e-04435557int:MTA2
InteractionMYOD1 interactions

ZFP30 PRMT5 SMAD1 SMAD2 SMAD3

1.85e-04194555int:MYOD1
InteractionKDM6B interactions

PRMT5 SMAD1 SMAD2 SMAD3

1.86e-04104554int:KDM6B
InteractionTGIF1 interactions

SMAD1 SMAD2 SMAD3

1.91e-0441553int:TGIF1
InteractionBACH1 interactions

OST4 SMAD1 SMAD3 SMAD5

2.39e-04111554int:BACH1
InteractionRUNX1 interactions

PRMT5 CCNK SMAD1 SMAD2 SMAD3 SMAD5

2.46e-04324556int:RUNX1
InteractionCYP11A1 interactions

SMAD2 SMAD3

2.60e-049552int:CYP11A1
InteractionKCTD13 interactions

NWD2 PLPPR4 TRIO MYO9A PRMT5 LARS1 NIPSNAP2 MTHFS AKR1B1 DCTN1 CNOT1 SLC4A1

3.10e-0413945512int:KCTD13
InteractionSKIL interactions

THSD7A SMAD1 SMAD2 SMAD3

3.12e-04119554int:SKIL
InteractionCDK8 interactions

PRMT5 SMAD1 SMAD2 SMAD3 SMAD5

3.45e-04222555int:CDK8
InteractionFOXO3 interactions

NIPSNAP2 SMAD1 SMAD2 SMAD3

3.65e-04124554int:FOXO3
InteractionRUNX2 interactions

SMAD1 SMAD2 SMAD3 SMAD5

3.88e-04126554int:RUNX2
InteractionMED24 interactions

SMAD1 SMAD2 SMAD3 SMAD5

4.12e-04128554int:MED24
InteractionNCAPD2 interactions

ZWILCH PRMT5 NEK7 ZNF598 DCTN1

4.38e-04234555int:NCAPD2
InteractionMXI1 interactions

PRMT5 SMAD1 SMAD5

4.56e-0455553int:MXI1
InteractionRGCC interactions

SMAD2 SMAD3

4.74e-0412552int:RGCC
InteractionSMAD6 interactions

SMAD1 SMAD2 SMAD5

4.81e-0456553int:SMAD6
CytobandEnsembl 112 genes in cytogenetic band chr7q33

AKR1B10 AKR1B15 AKR1B1

4.79e-0558553chr7q33
Cytoband7p21.3

THSD7A ETV1

5.22e-04285527p21.3
Cytoband16p12.3

ACSM2A ACSM2B

7.71e-043455216p12.3
Cytoband7q33

AKR1B10 AKR1B15

1.12e-03415527q33
Cytoband4p14

NWD2 ARAP2

1.18e-03425524p14
CytobandEnsembl 112 genes in cytogenetic band chr4p14

NWD2 ARAP2

2.96e-0367552chr4p14
CytobandEnsembl 112 genes in cytogenetic band chr7p21

THSD7A ETV1

5.16e-0389552chr7p21
GeneFamilySMAD family

SMAD1 SMAD2 SMAD3 SMAD5

1.29e-098394750
GeneFamilyAldo-keto reductases

AKR1B10 AKR1B15 AKR1B1

4.15e-0615393399
GeneFamilyAcyl-CoA synthetase family

ACSF2 ACSM2A ACSM2B

2.33e-052639340
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

BTK APBB1IP ARAP2

9.85e-03206393682
CoexpressionTURJANSKI_MAPK1_AND_MAPK2_TARGETS

SMAD1 SMAD2 SMAD3

1.90e-0612553M15804
CoexpressionGSE40068_CXCR5NEG_BCL6NEG_CD4_TCELL_VS_CXCR5POS_BCL6NEG_TFH_DN

B3GNT5 AKR1B10 NEK7 MTHFS SMAD3

6.28e-05200555M9263
CoexpressionGSE7764_IL15_NK_CELL_24H_VS_SPLENOCYTE_UP

ZWILCH PRMT5 LARS1 HARS1 SMAD1

6.28e-05200555M5725
CoexpressionGSE22886_NAIVE_BCELL_VS_BLOOD_PLASMA_CELL_UP

LARS1 TRMT2B APBB1IP SMAD3 ARAP2

6.28e-05200555M4440
CoexpressionGSE8621_LPS_STIM_VS_LPS_PRIMED_AND_LPS_STIM_MACROPHAGE_DN

B3GNT5 TRIO PRMT5 MTHFS LIN9

6.28e-05200555M6983
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_k-means-cluster#1_top-relative-expression-ranked_1000

B3GNT5 AKR1B10 CAPN6 NEK7 MTHFS SMAD3 SMAD5

2.76e-06240557gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_k1_1000
Drugpropranolol glycol

AKR1B10 AKR1B1 SLC4A1

7.41e-078553CID000037369
DrugLY2109761

SMAD1 SMAD2 SMAD3

1.58e-0610553ctd:C530108
Druglys-val

AKR1B10 AKR1B1 SLC4A1

1.58e-0610553CID000140709
DrugGlyceraldehyde

AKR1B10 AKR1B15 AKR1B1

1.58e-0610553ctd:D005985
DrugPentanones

AKR1B10 AKR1B1

5.73e-062552ctd:D010422
Drug4-hydroxyretinal

AKR1B10 AKR1B1

5.73e-062552ctd:C057180
Drug4-oxoretinaldehyde

AKR1B10 AKR1B1

5.73e-062552ctd:C099660
Drugpropioin

AKR1B10 AKR1B1

5.73e-062552ctd:C523189
Drugdehydroretinal

AKR1B10 AKR1B1

5.73e-062552ctd:C017184
DrugNefopam hydrochloride [23327-57-3]; Up 200; 13.8uM; HL60; HT_HG-U133A

HMOX2 HERC6 PLK3 APBB1IP SMAD3 SMAD5

7.69e-061965562355_UP
DrugNovobiocin sodium salt [1476-53-5]; Down 200; 6.4uM; HL60; HT_HG-U133A

HMOX2 IFIT2 PLK3 APBB1IP SMAD3 SMAD5

8.15e-061985562990_DN
Druglanthanum carbide

SMAD1 SMAD2 SMAD3

1.26e-0519553CID000123280
Drug2,4-hexadienal

AKR1B10 AKR1B1

1.72e-053552ctd:C079389
DrugAcetoin

AKR1B10 AKR1B1

1.72e-053552ctd:D000093
Drug2,3-butylene glycol

AKR1B10 AKR1B1

1.72e-053552ctd:C026978
Drug4-hydroxy-2-nonenal

ZWILCH ZFP30 AKR1B10 S1PR2 MTHFS FEM1C AKR1B1 IFIT2 CCNK SMAD1

1.85e-057985510ctd:C027576
Drugacetol

AKR1B10 HMOX2 AKR1B1

3.33e-0526553CID000008299
Drug5-Isothiocyanatoalrestatin

AKR1B10 AKR1B1

3.43e-054552CID000124861
Drug5-azidoalrestatin

AKR1B10 AKR1B1

3.43e-054552CID000128442
Drug5-(3-Thienyl)tetrazol-1-yl)acetic acid

AKR1B10 AKR1B1

3.43e-054552CID003035658
DrugFR-62765

AKR1B10 AKR1B1

3.43e-054552CID000128354
DrugM7HEQ

AKR1B10 AKR1B1

3.43e-054552CID006452329
Drug2,5-DHBQOP

AKR1B10 AKR1B1

3.43e-054552CID000069213
DrugNAP-HEX-Q

AKR1B10 AKR1B1

3.43e-054552CID005487149
DrugAC1NUTWC

ACSM2A ACSM2B

3.43e-054552CID005460914
DrugWF-2421

AKR1B10 AKR1B1

3.43e-054552CID000195567
Drugdanshenol B

AKR1B10 AKR1B1

3.43e-054552CID003083515
Drug4-chloro-3-hydroxybutanoate

AKR1B10 AKR1B1

3.43e-054552CID010129995
Drugiodomethanesulfonamide

AKR1B10 AKR1B1

3.43e-054552CID000519939
Drugsalviaflaside

AKR1B10 AKR1B1

3.43e-054552CID006438919
Drugmatteuorienate A

AKR1B10 AKR1B1

3.43e-054552CID000190958
Drugzopolrestat

AKR1B10 AKR1B15 AKR1B1

3.74e-0527553CID000001613
DrugM79175

AKR1B10 AKR1B1

5.70e-055552CID000115090
Drugxanthone-2

AKR1B10 AKR1B1

5.70e-055552CID005384285
Drug4'-deoxydoxorubicin

AKR1B10 HMOX2

5.70e-055552CID000044554
DrugAC1NE042

AKR1B10 AKR1B1

5.70e-055552CID004634410
DrugAC1L4VGL

AKR1B10 AKR1B1

5.70e-055552CID000213726
Drug4-chloro-3-nitrobenzaldehyde

AKR1B10 AKR1B1

5.70e-055552CID000085505
Drug2,3-hexanedione

AKR1B10 AKR1B1

5.70e-055552ctd:C043231
DrugICI 105552

AKR1B10 AKR1B1

5.70e-055552CID000133677
Drug2-(2,3,6-Trihydroxy-4-carboxyphenyl)ellagic acid

AKR1B10 AKR1B1

5.70e-055552CID006918808
DrugICI 222155

AKR1B10 AKR1B1

5.70e-055552CID000195716
DrugDN-108

AKR1B10 AKR1B1

5.70e-055552CID000183791
DrugAD-5467

AKR1B10 AKR1B1

5.70e-055552CID000197383
DrugBAL-ARI8

AKR1B10 AKR1B1

5.70e-055552CID000130098
Drug3-deoxyglucosone

TRIO AKR1B10 AKR1B1

5.72e-0531553CID000114839
Drug3'-deoxyguanosine

TRIO AKR1B10 AKR1B1

7.57e-0534553CID000165138
DrugMcat

SMAD1 SMAD2 SMAD3

8.26e-0535553CID003080785
Drugphenanthrene trans-1,2-dihydrodiol

AKR1B10 AKR1B1

8.54e-056552CID000115062
DrugICI 215918

AKR1B10 AKR1B1

8.54e-056552CID000129688
DrugAC1L28UN

AKR1B10 AKR1B1

8.54e-056552CID000068017
DrugM16287

AKR1B10 AKR1B1

8.54e-056552CID000188399
Drugp225

AKR1B10 AKR1B1

8.54e-056552CID000014589
DrugADN-138

AKR1B10 AKR1B1

8.54e-056552CID000127323
DrugBAPSG

AKR1B10 AKR1B1

8.54e-056552CID000130998
Drug1,2,4-triazol-3-one

AKR1B10 AKR1B1

8.54e-056552CID011073339
Drugcapillarisin

AKR1B10 AKR1B1

8.54e-056552CID005281342
Drug3,5-dichlorosalicylic acid

AKR1B10 AKR1B1

8.54e-056552CID000009445
Drug1,2-dithiole-3-thione

AKR1B10 HMOX2 AKR1B1

1.15e-0439553CID000068296
DrugCytochalasin D

SMAD1 SMAD2 SMAD3

1.15e-0439553ctd:D015638
Drug1,3,2-dioxaborolan-2-ol

SMAD1 SMAD2 SMAD3 SMAD5

1.17e-04104554CID005289333
Drug4-nitrobenzaldehyde

AKR1B15 AKR1B1

1.19e-047552ctd:C029915
Drugmyrciacitrin I

AKR1B10 AKR1B1

1.19e-047552CID000183137
Drugfriedelane

AKR1B10 AKR1B1

1.19e-047552CID000634354
Drug5-methoxypsoralen

SMAD1 SMAD5

1.19e-047552ctd:C022909
Drug3-formylbenzoic acid

AKR1B10 AKR1B1

1.19e-047552CID000012077
Drugtetramethylene glutaric acid

AKR1B10 AKR1B1

1.19e-047552CID000085558
Drugguaijaverin

AKR1B10 AKR1B1

1.19e-047552CID005317847
Drugdesmanthin-1

AKR1B10 AKR1B1

1.19e-047552CID005316590
Drugrosiglitazone; Down 200; 10uM; MCF7; HT_HG-U133A

MYO9A HMOX2 SMAD3 ARAP2 SMAD5

1.21e-042005556992_DN
DrugAC1L1FQE

AKR1B10 AKR1B1 LIN9

1.54e-0443553CID000003349
Drugerythritol 4-phosphate

AKR1B10 AKR1B1

1.59e-048552CID000192838
Drug4-hydroxynonanoate

AKR1B10 AKR1B1

1.59e-048552CID000134653
DrugRisarestat

AKR1B10 AKR1B1

1.59e-048552CID000133264
Drug6-pyridoxyllysine

AKR1B10 AKR1B1

1.59e-048552CID000160700
Drug1,2-diaminoguanidine

AKR1B10 AKR1B1

1.59e-048552CID000170039
Drug20-CHO-LTB4

AKR1B10 AKR1B1

1.59e-048552CID006449839
DrugCP-166,572

AKR1B10 AKR1B1

1.59e-048552CID000132302
DrugLDN 193189

SMAD1 SMAD5

1.59e-048552ctd:C554430
Drugalcophosphamide

AKR1B10 AKR1B1

1.59e-048552CID000098612
Drugeutypine

AKR1B10 AKR1B1

1.59e-048552CID000129326
DrugSG-210

AKR1B10 AKR1B1

1.59e-048552CID000132542
DrugNSC633676

AKR1B10 AKR1B1

1.59e-048552CID000133894
Drug3 Na

AKR1B10 AKR1B1

1.59e-048552CID000157838
DrugAC1L1K15

SMAD1 SMAD2 SMAD3 SMAD5

2.03e-04120554CID000005293
DrugAL3152

AKR1B10 AKR1B1

2.04e-049552CID000159501
DrugAC1Q5HJP

AKR1B10 AKR1B1

2.04e-049552CID000000067
Drug3-deoxyfructose

AKR1B10 AKR1B1

2.04e-049552CID003080627
Drugpotassium amyl xanthate

AKR1B10 AKR1B1

2.04e-049552CID000017635
Drugmetyrapol

AKR1B10 AKR1B1

2.04e-049552CID000161210
Drugmycaminose

AKR1B10 AKR1B1

2.55e-0410552CID000160504
Drug2,3-hexanedione

AKR1B10 AKR1B1

2.55e-0410552CID000019707
DrugHexanones

AKR1B10 AKR1B1

2.55e-0410552ctd:D006588
Drug3-fluoro-3-deoxy-D-glucose

AKR1B10 AKR1B1

2.55e-0410552CID000122305
Drugprotocatechualdehyde

SMAD2 SMAD3

2.55e-0410552ctd:C005581
DrugDihydroxydihydrobenzopyrenes

AKR1B10 AKR1B1

3.11e-0411552ctd:D004101
DrugWen-pi-tang-Hab-Wu-ling-san

SMAD2 SMAD3

3.11e-0411552ctd:C521629
Drugchlordecone alcohol

AKR1B10 AKR1B1

3.11e-0411552CID000013946
DrugNSC 60462

AKR1B10 AKR1B1

3.11e-0411552CID000097943
Drugphytochromobilin

HMOX2 SLC4A1

3.11e-0411552CID006449958
DiseaseX-21319 measurement

ACSM2A ACSM2B

3.17e-062532EFO_0800807
DiseaseX-11478 measurement

ACSM2A ACSM2B

9.49e-063532EFO_0021242
Diseasealdose reductase measurement

AKR1B10 AKR1B1

1.89e-054532EFO_0801364
Disease3-hydroxyhexanoate measurement

ACSM2A ACSM2B

3.15e-055532EFO_0800378
Diseaseindoleacetoylcarnitine measurement

ACSM2A ACSM2B

4.73e-056532EFO_0800106
DiseaseLoeys-Dietz Syndrome

SMAD2 SMAD3

6.61e-057532C2697932
Diseasesymmetrical dimethylarginine measurement

AKR1B10 AKR1B15

1.13e-049532EFO_0006523
Diseasewhite matter growth measurement

AKR1B10 AKR1B1

1.13e-049532EFO_0009335
Diseasejuvenile polyposis syndrome (implicated_via_orthology)

SMAD1 SMAD5

2.44e-0413532DOID:0050787 (implicated_via_orthology)
DiseaseLeft Ventricle Remodeling

SMAD2 SMAD3

6.50e-0421532C0600520
DiseaseVentricular Remodeling

SMAD2 SMAD3

6.50e-0421532C0600519
DiseaseLynch syndrome (is_implicated_in)

SMAD2 SMAD3

8.52e-0424532DOID:3883 (is_implicated_in)
DiseaseCocaine-Related Disorders

SMAD1 SMAD3 SMAD5

1.23e-03117533C0236736
DiseaseCocaine Abuse

SMAD1 SMAD3 SMAD5

1.56e-03127533C0009171

Protein segments in the cluster

PeptideGeneStartEntry
INYPKVSASVHQYNK

ARSK

471

Q6UWY0
YKCQHQQVNESEPVY

FCER1A

91

P12319
NVEPLTKAIKYYQHL

DCTN1

716

Q14203
IKIFQDHPLQKTYNY

SLC4A1

541

P02730
VIRYNSDLVQKYHPC

BTK

131

Q06187
ELQQHVKSVTAPYKY

ACSM2A

526

Q08AH3
CFVLKHPQIQKESQY

APBB1IP

381

Q7Z5R6
HPQIQKESQYIKYLC

APBB1IP

386

Q7Z5R6
QVEHPYQFLLKYAKQ

CCNK

156

O75909
LKYKPVTNQVECHPY

AKR1B10

176

O60218
ECHPYLTQEKLIQYC

AKR1B10

186

O60218
FKTQQYYNVLKQICP

ACSF2

181

Q96CM8
CKYIYQKNGDPLHIS

ARAP2

1146

Q8WZ64
ECHPYLTQEKLIQYC

AKR1B1

186

P15121
VNYRCLVQSYPKKIH

NWD2

476

Q9ULI1
KYPKNIVENHTAYLV

RAD51AP2

616

Q09MP3
SNLYKLQFHNVKPEC

NIPSNAP2

71

O75323
PKSHQKCRQYYPVTI

RFTN1

286

Q14699
IYLPNVKVLCLNYNH

LRRC9

1136

Q6ZRR7
PCTLEQDHFKKQTIY

FEM1C

456

Q96JP0
YLKRCLQHQEVKPYT

MTHFS

156

P49914
LHKVQQYCYELAPDQ

LIN9

406

Q5TKA1
VRKDYKYVQCGVQPQ

TMEM63C

356

Q9P1W3
KIYSIYHQPNKNQTK

KIAA1586

446

Q9HCI6
LKQLNHPNVIKYYAS

NEK7

86

Q8TDX7
KCLYNVSAYDQKPQV

ETV1

116

P50549
KYEQGYQKSHPTIQL

HERC6

916

Q8IVU3
QCPKAAQKYVERIHY

HMOX2

126

P30519
LVVLYHYVAVNNPKK

OST4

21

P0C6T2
PRYQYLINHKEKCQA

B3GNT5

71

Q9BYG0
IYVPQNVYCIHVDEK

GCNT7

131

Q6ZNI0
KTKYHYQPQLDQQTL

C1orf100

61

Q5SVJ3
PIKYSQYQQAIYKCL

PRMT5

331

O14744
KKALEYIPNNAYLHC

IFIT2

271

P09913
KYANETVNPYLVIKC

CAPN6

531

Q9Y6Q1
PNKVQEHYNYTKETL

S1PR2

11

O95136
LYKKNPKLLNQLQYC

HARS1

441

P12081
YNVKQLKLHCTVPAY

UTP4

511

Q969X6
LKNIPEKHSQVAQYY

TRMT2B

191

Q96GJ1
KCKNSHLYPLIETQY

THSD7A

941

Q9UPZ6
QKPSHCTIYVAKNYP

LARS1

931

Q9P2J5
LKKHCPNQYQIYSES

SAMD12

86

Q8N8I0
SKQKEVCINPYHYKR

SMAD5

116

Q99717
KQKEVCINPYHYKRV

SMAD1

116

Q15797
LKYKPVTNQVECHPY

AKR1B15

176

C9JRZ8
ECHPYLTQEKLIQYC

AKR1B15

186

C9JRZ8
ELQQHVKSVTAPYKY

ACSM2B

526

Q68CK6
FKNRLKDYPQYCQHL

CNOT1

961

A5YKK6
TRITQYKNHPVDVYC

PLPPR4

296

Q7Z2D5
KETYRCIKQVHYTLP

PLK3

266

Q9H4B4
LTQICIKYYKQNPLD

ZWILCH

491

Q9H900
IKYYKQNPLDEQHIF

ZWILCH

496

Q9H900
PLYQKSHNREKPYEC

ZFP30

146

Q9Y2G7
KKDEVCVNPYHYQRV

SMAD2

156

Q15796
KKDEVCVNPYHYQRV

SMAD3

116

P84022
LINHQGIYTNEKPYK

ZNF582

186

Q96NG8
KVYALYRQLLQHECP

ZNF598

106

Q86UK7
YCQNKPKSEHIVSEY

TRIO

2061

O75962
VCGKIFNQKQYIVYH

ZNF816

261

Q0VGE8
KQPEEYHYLNQITKK

MYO9A

356

B2RTY4