Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transition metal ion binding	PHF2 DPEP1 MYCBP2 PRICKLE1 CPO CH25H ADAMTS13 HRNR PHF8 TRIM6 FLG2 MMP26 ZZEF1 PPM1A	2.28e-05	1189	65	14	GO:0046914
GeneOntologyMolecularFunction	peptidase activity	DPEP1 USP17L2 USP17L1 CPO USP17L3 ADAMTS13 EIF3F MMP26 MASP2 GGT5	4.67e-05	654	65	10	GO:0008233
GeneOntologyMolecularFunction	histone H4K20 demethylase activity	PHF2 PHF8	6.23e-05	4	65	2	GO:0035575
GeneOntologyMolecularFunction	histone H4 demethylase activity	PHF2 PHF8	1.04e-04	5	65	2	GO:0141058
GeneOntologyMolecularFunction	calcium ion binding	PCDHGB5 PCDHGB1 PCDHGB4 PKD2L1 ADAMTS13 HRNR RAPGEF2 FLG2 ZZEF1 MASP2	1.44e-04	749	65	10	GO:0005509
GeneOntologyMolecularFunction	chitinase activity	CHI3L1 CHIT1	1.55e-04	6	65	2	GO:0004568
GeneOntologyMolecularFunction	methylated histone binding	PHF2 CHD1 PHF8 ZZEF1	1.78e-04	86	65	4	GO:0035064
GeneOntologyMolecularFunction	methylation-dependent protein binding	PHF2 CHD1 PHF8 ZZEF1	1.94e-04	88	65	4	GO:0140034
GeneOntologyMolecularFunction	chitin binding	CHI3L1 CHIT1	2.88e-04	8	65	2	GO:0008061
GeneOntologyMolecularFunction	metallopeptidase activity	DPEP1 CPO ADAMTS13 EIF3F MMP26	4.86e-04	200	65	5	GO:0008237
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP17L2 USP17L1 USP17L3 EIF3F	5.22e-04	114	65	4	GO:0004843
GeneOntologyMolecularFunction	zinc ion binding	PHF2 DPEP1 MYCBP2 PRICKLE1 CPO ADAMTS13 PHF8 TRIM6 MMP26 ZZEF1	5.73e-04	891	65	10	GO:0008270
GeneOntologyMolecularFunction	deubiquitinase activity	USP17L2 USP17L1 USP17L3 EIF3F	7.16e-04	124	65	4	GO:0101005
GeneOntologyMolecularFunction	histone H3K9 demethylase activity	PHF2 PHF8	9.26e-04	14	65	2	GO:0032454
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	USP17L2 USP17L1 USP17L3 EIF3F	1.04e-03	137	65	4	GO:0019783
GeneOntologyBiologicalProcess	negative regulation of rDNA heterochromatin formation	PHF2 PHF8	9.48e-06	2	64	2	GO:0061188
GeneOntologyBiologicalProcess	regulation of rDNA heterochromatin formation	PHF2 PHF8	2.84e-05	3	64	2	GO:0061187
GeneOntologyBiologicalProcess	chitin catabolic process	CHI3L1 CHIT1	1.41e-04	6	64	2	GO:0006032
GeneOntologyBiologicalProcess	chitin metabolic process	CHI3L1 CHIT1	1.41e-04	6	64	2	GO:0006030
GeneOntologyBiologicalProcess	negative regulation of heterochromatin formation	PHF2 PHF8	1.41e-04	6	64	2	GO:0031452
GeneOntologyBiologicalProcess	negative regulation of chromatin organization	PHF2 PHF8	1.97e-04	7	64	2	GO:1905268
GeneOntologyBiologicalProcess	modified amino acid catabolic process	DMGDH DPEP1 GGT5	2.05e-04	37	64	3	GO:0042219
GeneOntologyCellularComponent	keratohyalin granule	HRNR FLG2	9.46e-05	5	65	2	GO:0036457
Domain	Chitinase_insertion	CHI3L1 CHIT1	1.15e-04	5	64	2	IPR029070
Domain	-	CHI3L1 CHIT1	1.15e-04	5	64	2	3.10.50.10
Domain	Glyco_hydro_18_chit_AS	CHI3L1 CHIT1	1.72e-04	6	64	2	IPR001579
Domain	Glyco_hydro18_cat	CHI3L1 CHIT1	2.40e-04	7	64	2	IPR001223
Domain	Glyco_hydro_18	CHI3L1 CHIT1	2.40e-04	7	64	2	PF00704
Domain	Chitinase_II	CHI3L1 CHIT1	2.40e-04	7	64	2	IPR011583
Domain	APC_su10/DOC_dom	MYCBP2 ZZEF1	2.40e-04	7	64	2	IPR004939
Domain	Glyco_18	CHI3L1 CHIT1	2.40e-04	7	64	2	SM00636
Domain	DOC	MYCBP2 ZZEF1	2.40e-04	7	64	2	PS51284
Domain	CHITINASE_18	CHI3L1 CHIT1	2.40e-04	7	64	2	PS01095
Domain	APC10	MYCBP2 ZZEF1	2.40e-04	7	64	2	SM01337
Domain	ANAPC10	MYCBP2 ZZEF1	2.40e-04	7	64	2	PF03256
Domain	Cadherin_tail	PCDHGB5 PCDHGB1 PCDHGB4	2.74e-04	37	64	3	PF15974
Domain	Cadherin_CBD	PCDHGB5 PCDHGB1 PCDHGB4	2.74e-04	37	64	3	IPR031904
Domain	Glyco_hydro_catalytic_dom	DPEP1 CHI3L1 CHIT1	2.97e-04	38	64	3	IPR013781
Domain	Cadherin_C	PCDHGB5 PCDHGB1 PCDHGB4	4.00e-04	42	64	3	IPR032455
Domain	Cadherin_C_2	PCDHGB5 PCDHGB1 PCDHGB4	4.00e-04	42	64	3	PF16492
Domain	Cadherin	KIAA0319 PCDHGB5 PCDHGB1 PCDHGB4	7.18e-04	118	64	4	IPR002126
Domain	TIL	SSPOP MUC6	7.46e-04	12	64	2	PF01826
Domain	C8	SSPOP MUC6	7.46e-04	12	64	2	PF08742
Domain	Glycoside_hydrolase_SF	CHI3L1 CHIT1 GAA	7.96e-04	53	64	3	IPR017853
Domain	Unchr_dom_Cys-rich	SSPOP MUC6	8.80e-04	13	64	2	IPR014853
Domain	C8	SSPOP MUC6	8.80e-04	13	64	2	SM00832
Domain	CUB_dom	ADAMTS13 ZZEF1 MASP2	9.84e-04	57	64	3	IPR000859
Domain	PP2C_SIG	PPM1H PPM1A	1.02e-03	14	64	2	SM00331
Domain	TIL_dom	SSPOP MUC6	1.02e-03	14	64	2	IPR002919
Domain	PPM_1	PPM1H PPM1A	1.18e-03	15	64	2	PS01032
Domain	Homeobox	RHOXF2B TSHZ3 CUX2 RHOXF2 DLX4	1.24e-03	234	64	5	PF00046
Domain	HOMEOBOX_1	RHOXF2B TSHZ3 CUX2 RHOXF2 DLX4	1.28e-03	236	64	5	PS00027
Domain	HOX	RHOXF2B TSHZ3 CUX2 RHOXF2 DLX4	1.31e-03	237	64	5	SM00389
Domain	VWD	SSPOP MUC6	1.34e-03	16	64	2	SM00216
Domain	VWF_type-D	SSPOP MUC6	1.34e-03	16	64	2	IPR001846
Domain	VWFD	SSPOP MUC6	1.34e-03	16	64	2	PS51233
Domain	HABP4_PAI-RBP1	USP17L2 USP17L3	1.34e-03	16	64	2	PF04774
Domain	HABP4_PAIRBP1-bd	USP17L2 USP17L3	1.34e-03	16	64	2	IPR006861
Domain	VWD	SSPOP MUC6	1.34e-03	16	64	2	PF00094
Domain	HOMEOBOX_2	RHOXF2B TSHZ3 CUX2 RHOXF2 DLX4	1.36e-03	239	64	5	PS50071
Domain	Homeobox_dom	RHOXF2B TSHZ3 CUX2 RHOXF2 DLX4	1.36e-03	239	64	5	IPR001356
Domain	Cadherin_2	PCDHGB5 PCDHGB1 PCDHGB4	1.44e-03	65	64	3	PF08266
Domain	Cadherin_N	PCDHGB5 PCDHGB1 PCDHGB4	1.44e-03	65	64	3	IPR013164
Domain	USP_CS	USP17L2 USP17L1 USP17L3	1.51e-03	66	64	3	IPR018200
Domain	PP2C	PPM1H PPM1A	1.52e-03	17	64	2	IPR015655
Domain	UCH	USP17L2 USP17L1 USP17L3	1.86e-03	71	64	3	PF00443
Domain	USP_2	USP17L2 USP17L1 USP17L3	1.86e-03	71	64	3	PS00973
Domain	VWC_out	SSPOP MUC6	1.90e-03	19	64	2	SM00215
Domain	PP2C	PPM1H PPM1A	1.90e-03	19	64	2	PF00481
Domain	USP_3	USP17L2 USP17L1 USP17L3	1.93e-03	72	64	3	PS50235
Domain	USP_dom	USP17L2 USP17L1 USP17L3	1.93e-03	72	64	3	IPR028889
Domain	Peptidase_C19_UCH	USP17L2 USP17L1 USP17L3	1.93e-03	72	64	3	IPR001394
Domain	-	MYCBP2 ZZEF1 SSPOP	2.01e-03	73	64	3	2.60.120.260
Domain	PP2Cc	PPM1H PPM1A	2.11e-03	20	64	2	SM00332
Domain	PPM-type_phosphatase_dom	PPM1H PPM1A	2.11e-03	20	64	2	IPR001932
Domain	-	PPM1H PPM1A	2.11e-03	20	64	2	3.60.40.10
Domain	PPM_2	PPM1H PPM1A	2.11e-03	20	64	2	PS51746
Domain	-	RHOXF2B TSHZ3 CUX2 RHOXF2 DLX4	2.84e-03	283	64	5	1.10.10.60
Domain	Peptidase_M10	ADAMTS13 MMP26	3.04e-03	24	64	2	PF00413
Domain	JmjC	PHF2 PHF8	3.04e-03	24	64	2	PF02373
Domain	Cys_knot_C	SSPOP MUC6	3.30e-03	25	64	2	IPR006207
Domain	CTCK_2	SSPOP MUC6	3.30e-03	25	64	2	PS01225
Domain	Homeobox_CS	RHOXF2B CUX2 RHOXF2 DLX4	3.80e-03	186	64	4	IPR017970
Domain	S100_CABP	HRNR FLG2	3.84e-03	27	64	2	PS00303
Domain	S_100	HRNR FLG2	3.84e-03	27	64	2	PF01023
Domain	Galactose-bd-like	MYCBP2 ZZEF1 SSPOP	4.12e-03	94	64	3	IPR008979
Domain	S100_Ca-bd_sub	HRNR FLG2	4.13e-03	28	64	2	IPR013787
Domain	S100/CaBP-9k_CS	HRNR FLG2	4.13e-03	28	64	2	IPR001751
Domain	S_100	HRNR FLG2	4.13e-03	28	64	2	SM01394
Domain	JMJC	PHF2 PHF8	5.37e-03	32	64	2	PS51184
Domain	JmjC_dom	PHF2 PHF8	5.37e-03	32	64	2	IPR003347
Domain	Homeodomain-like	RHOXF2B TSHZ3 CUX2 RHOXF2 DLX4	5.57e-03	332	64	5	IPR009057
Domain	JmjC	PHF2 PHF8	5.70e-03	33	64	2	SM00558
Domain	Cadherin_CS	PCDHGB5 PCDHGB1 PCDHGB4	6.22e-03	109	64	3	IPR020894
Domain	-	CHI3L1 CHIT1	6.39e-03	35	64	2	3.20.20.80
Pubmed	High Dub3 expression in mouse ESCs couples the G1/S checkpoint to pluripotency.	USP17L2 USP17L1 USP17L3	7.41e-07	10	65	3	24207026
Pubmed	Cell cycle-dependent expression of Dub3, Nanog and the p160 family of nuclear receptor coactivators (NCoAs) in mouse embryonic stem cells.	USP17L2 USP17L1 USP17L3	1.35e-06	12	65	3	24695638
Pubmed	ES cell neural differentiation reveals a substantial number of novel ESTs.	USP17L2 USP17L1 USP17L3	2.23e-06	14	65	3	11793228
Pubmed	Maturation of postnatally generated olfactory bulb granule cells depends on functional γ-protocadherin expression.	PCDHGB5 PCDHGB1 PCDHGB4	2.79e-06	15	65	3	23515096
Pubmed	Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages.	CHI3L1 CHIT1	3.44e-06	2	65	2	9492324
Pubmed	Chitotriosidase as a possible marker of clinically evidenced atherosclerosis in dyslipidemic children.	CHI3L1 CHIT1	3.44e-06	2	65	2	24572981
Pubmed	Chitotriosidase and YKL-40 in normal and pre-eclamptic pregnancies.	CHI3L1 CHIT1	3.44e-06	2	65	2	18054022
Pubmed	Increased YKL-40 and Chitotriosidase in Asthma and Chronic Obstructive Pulmonary Disease.	CHI3L1 CHIT1	3.44e-06	2	65	2	26372680
Pubmed	Cloning and characterization of Ehox, a novel homeobox gene essential for embryonic stem cell differentiation.	RHOXF2B RHOXF2	3.44e-06	2	65	2	12087094
Pubmed	Differential Glial Chitotriosidase 1 and Chitinase 3-like Protein 1 Expression in the Human Primary Visual Cortex and Cerebellum after Global Hypoxia-Ischemia.	CHI3L1 CHIT1	3.44e-06	2	65	2	36332693
Pubmed	Longitudinal and Comparative Measures of Serum Chitotriosidase and YKL-40 in Patients With Idiopathic Pulmonary Fibrosis.	CHI3L1 CHIT1	3.44e-06	2	65	2	35222369
Pubmed	Rhox homeobox gene cluster: recent duplication of three family members.	RHOXF2B RHOXF2	3.44e-06	2	65	2	16496311
Pubmed	Serum YKL-40 levels and chitotriosidase activity as potential biomarkers in primary prostate cancer and benign prostatic hyperplasia.	CHI3L1 CHIT1	3.44e-06	2	65	2	18190830
Pubmed	Serum chitotriosidase and YKL-40 in acute pancreatitis: Reliability as prognostic marker for disease severity and correlation with inflammatory markers.	CHI3L1 CHIT1	3.44e-06	2	65	2	34579512
Pubmed	Increased Plasma YKL-40 Level and Chitotriosidase Activity in Cystic Fibrosis Patients.	CHI3L1 CHIT1	3.44e-06	2	65	2	34637032
Pubmed	Evaluation of CHI3L-1 and CHIT-1 expression in differentiated and polarized macrophages.	CHI3L1 CHIT1	3.44e-06	2	65	2	23149946
Pubmed	Proteins from the 18 glycosyl hydrolase family are associated with kidney dysfunction in patients with diabetes type 2.	CHI3L1 CHIT1	3.44e-06	2	65	2	25519006
Pubmed	Cross-sectional and longitudinal measures of chitinase proteins in amyotrophic lateral sclerosis and expression of CHI3L1 in activated astrocytes.	CHI3L1 CHIT1	3.44e-06	2	65	2	31937582
Pubmed	Determination of chitinases family during osteoclastogenesis.	CHI3L1 CHIT1	3.44e-06	2	65	2	24440516
Pubmed	Identification of a tandem duplicated array in the Rhox alpha locus on mouse chromosome X.	RHOXF2B RHOXF2	3.44e-06	2	65	2	16465597
Pubmed	Cloning and characterization of the 5'-flanking region of the Ehox gene.	RHOXF2B RHOXF2	3.44e-06	2	65	2	16414020
Pubmed	Cleavage of leukotriene D4 in mice with targeted disruption of a membrane-bound dipeptidase gene.	DPEP1 GGT5	3.44e-06	2	65	2	10667344
Pubmed	CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1.	USP17L2 USP17L1 USP17L3	5.91e-06	19	65	3	28067227
Pubmed	DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes.	USP17L2 USP17L1 USP17L3	8.09e-06	21	65	3	11468161
Pubmed	The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor.	USP17L2 USP17L1 USP17L3	8.09e-06	21	65	3	8756639
Pubmed	DUB-1, a deubiquitinating enzyme with growth-suppressing activity.	USP17L2 USP17L1 USP17L3	8.09e-06	21	65	3	8622927
Pubmed	DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes.	USP17L2 USP17L1 USP17L3	8.09e-06	21	65	3	14583620
Pubmed	Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines.	USP17L2 USP17L1 USP17L3	8.09e-06	21	65	3	12447969
Pubmed	DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway.	USP17L2 USP17L1 USP17L3	8.09e-06	21	65	3	18980247
Pubmed	A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain.	TMEM168 SLC39A6 CHD1 RAPGEF2	8.27e-06	68	65	4	22779921
Pubmed	JAK2 is required for induction of the murine DUB-1 gene.	USP17L2 USP17L1 USP17L3	9.35e-06	22	65	3	9154835
Pubmed	Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.	HRNR FLG2	1.03e-05	3	65	2	23403047
Pubmed	Chitinase effects on immune cell response in neuromyelitis optica and multiple sclerosis.	CHI3L1 CHIT1	1.03e-05	3	65	2	21159721
Pubmed	Fungal exposure modulates the effect of polymorphisms of chitinases on emergency department visits and hospitalizations.	CHI3L1 CHIT1	1.03e-05	3	65	2	20538957
Pubmed	The RHOX5 homeodomain protein mediates transcriptional repression of the netrin-1 receptor gene Unc5c.	RHOXF2B RHOXF2	1.03e-05	3	65	2	18077458
Pubmed	PHD finger protein 2 (PHF2) represses ribosomal RNA gene transcription by antagonizing PHF finger protein 8 (PHF8) and recruiting methyltransferase SUV39H1.	PHF2 PHF8	1.03e-05	3	65	2	25204660
Pubmed	The chitinase and chitinase-like proteins: a review of genetic and functional studies in asthma and immune-mediated diseases.	CHI3L1 CHIT1	1.03e-05	3	65	2	19644363
Pubmed	Polymorphisms of chitinases are not associated with asthma.	CHI3L1 CHIT1	1.03e-05	3	65	2	20226308
Pubmed	The rhox homeobox gene family shows sexually dimorphic and dynamic expression during mouse embryonic gonad development.	RHOXF2B RHOXF2	1.03e-05	3	65	2	18562707
Pubmed	Association of plasma YKL-40 with brain amyloid-β levels, memory performance, and sex in subjective memory complainers.	CHI3L1 CHIT1	1.03e-05	3	65	2	32920471
Pubmed	Different neuroinflammatory profile in amyotrophic lateral sclerosis and frontotemporal dementia is linked to the clinical phase.	CHI3L1 CHIT1	1.03e-05	3	65	2	30224549
Pubmed	Breast regression protein-39 is not required for experimental autoimmune encephalomyelitis induction.	CHI3L1 CHIT1	1.03e-05	3	65	2	26079949
Pubmed	DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes.	USP17L2 USP17L1 USP17L3	1.23e-05	24	65	3	8995226
Pubmed	Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.	USP17L2 USP17L1 USP17L3	1.39e-05	25	65	3	21115691
Pubmed	Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice.	USP17L2 USP17L1 USP17L3	1.57e-05	26	65	3	35816173
Pubmed	Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.	PCDHGB5 PCDHGB1 PCDHGB4	1.97e-05	28	65	3	15347688
Pubmed	Rhox: a new homeobox gene cluster.	RHOXF2B RHOXF2	2.06e-05	4	65	2	15707895
Pubmed	Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.	USP17L2 USP17L1 USP17L3	2.20e-05	29	65	3	32527007
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	PHF2 MTMR12 MYCBP2 WDR11 SLC39A6 KIF14 PHF8 SUFU PPM1H PPM1A	2.37e-05	1049	65	10	27880917
Pubmed	Cdc25A and Dub3 in a high-stakes balancing act.	USP17L2 USP17L1 USP17L3	3.27e-05	33	65	3	20228807
Pubmed	Expression of a novel homeobox gene Ehox in trophoblast stem cells and pharyngeal pouch endoderm.	RHOXF2B RHOXF2	3.43e-05	5	65	2	14648851
Pubmed	Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme.	USP17L2 USP17L1 USP17L3	3.58e-05	34	65	3	20715989
Pubmed	Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation.	USP17L2 USP17L1 USP17L3	3.58e-05	34	65	3	9806828
Pubmed	The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.	USP17L2 USP17L1 USP17L3	3.58e-05	34	65	3	20368735
Pubmed	The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence.	USP17L2 USP17L1 USP17L3	3.58e-05	34	65	3	15780755
Pubmed	Functional significance of isoform diversification in the protocadherin gamma gene cluster.	PCDHGB5 PCDHGB1 PCDHGB4	3.58e-05	34	65	3	22884324
Pubmed	The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.	USP17L2 USP17L1 USP17L3	3.58e-05	34	65	3	20403174
Pubmed	USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.	USP17L2 USP17L1 USP17L3	3.58e-05	34	65	3	19188362
Pubmed	Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability.	USP17L2 USP17L1 USP17L3	3.58e-05	34	65	3	17109758
Pubmed	Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene.	USP17L2 USP17L1 USP17L3	3.58e-05	34	65	3	11941478
Pubmed	The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.	USP17L2 USP17L1 USP17L3	3.58e-05	34	65	3	20388806
Pubmed	DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation.	USP17L2 USP17L1 USP17L3	3.58e-05	34	65	3	14699124
Pubmed	The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter.	USP17L2 USP17L1 USP17L3	3.58e-05	34	65	3	10936051
Pubmed	The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.	USP17L2 USP17L1 USP17L3	3.58e-05	34	65	3	21448158
Pubmed	Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.	USP17L2 USP17L1 USP17L3	3.91e-05	35	65	3	21239494
Pubmed	Cytokine-regulated protein degradation by the ubiquitination system.	USP17L2 USP17L1 USP17L3	3.91e-05	35	65	3	16611142
Pubmed	The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.	USP17L2 USP17L1 USP17L3	4.26e-05	36	65	3	20147298
Pubmed	Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.	USP17L2 USP17L1 USP17L3	4.63e-05	37	65	3	20228808
Pubmed	A differential developmental pattern of spinal interneuron apoptosis during synaptogenesis: insights from genetic analyses of the protocadherin-gamma gene cluster.	PCDHGB5 PCDHGB1 PCDHGB4	7.81e-05	44	65	3	19029045
Pubmed	PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.	SPI1 MYCBP2 PRICKLE1 CDC16 ZZEF1	1.01e-04	247	65	5	32989298
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	USP17L2 USP17L1 USP17L3	1.15e-04	50	65	3	31806660
Pubmed	The Dorsal Wave of Neocortical Oligodendrogenesis Begins Embryonically and Requires Multiple Sources of Sonic Hedgehog.	CUX2 SUFU	1.23e-04	9	65	2	29739868
Pubmed	N-Myristoylation is essential for protein phosphatases PPM1A and PPM1B to dephosphorylate their physiological substrates in cells.	PPM1H PPM1A	1.23e-04	9	65	2	23088624
Pubmed	Cell-cell adhesion defects in Mrj mutant trophoblast cells are associated with failure to pattern the chorion during early placental development.	RHOXF2B RHOXF2	1.53e-04	10	65	2	21972064
Pubmed	Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.	PCDHGB5 PCDHGB1 PCDHGB4	1.70e-04	57	65	3	32633719
Pubmed	A major X-linked locus affects kidney function in mice.	RHOXF2B RHOXF2	2.24e-04	12	65	2	23011808
Pubmed	Deletion of the Syncytin A receptor Ly6e impairs syncytiotrophoblast fusion and placental morphogenesis causing embryonic lethality in mice.	RHOXF2B RHOXF2	2.24e-04	12	65	2	29500366
Pubmed	Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development.	PRICKLE1 FZD10	2.65e-04	13	65	2	21246654
Pubmed	The G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting complex containing CDC20.	CDC16 PHF8	2.65e-04	13	65	2	23979597
Pubmed	Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease.	CHI3L1 CHIT1	2.65e-04	13	65	2	28431248
Pubmed	A phospho/methyl switch at histone H3 regulates TFIID association with mitotic chromosomes.	PHF2 PHF8	2.65e-04	13	65	2	20953165
Pubmed	Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.	PCDHGB5 PCDHGB1 PCDHGB4	2.86e-04	68	65	3	11230163
Pubmed	Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium.	PRICKLE1 CH25H	3.08e-04	14	65	2	20445134
Pubmed	Molecular interaction between projection neuron precursors and invading interneurons via stromal-derived factor 1 (CXCL12)/CXCR4 signaling in the cortical subventricular zone/intermediate zone.	CUX2 DLX4	3.08e-04	14	65	2	17182777
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	MTMR12 SSPOP MUC6	3.25e-04	71	65	3	33541421
Pubmed	A striking organization of a large family of human neural cadherin-like cell adhesion genes.	PCDHGB5 PCDHGB1 PCDHGB4	3.39e-04	72	65	3	10380929
Pubmed	Nucleosome-interacting proteins regulated by DNA and histone methylation.	CHD1 PHF8	3.56e-04	15	65	2	21029866
Pubmed	Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.	PCDHGB5 PCDHGB1 PCDHGB4	3.67e-04	74	65	3	10817752
Pubmed	TRIM30 modulates Interleukin-22-regulated papillary thyroid Cancer cell migration and invasion by targeting Sox17 for K48-linked Polyubiquitination.	HRNR FLG2	4.06e-04	16	65	2	31823782
Pubmed	Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.	PCDHGB5 PCDHGB1 PCDHGB4	4.13e-04	77	65	3	10835267
Pubmed	Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.	TSHZ3 TMEM168 MYCBP2 PRICKLE1 CRYGN CDC16 KIF14 CHD1 RAPGEF2	4.14e-04	1215	65	9	15146197
Pubmed	Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.	PCDHGB5 PCDHGB1 PCDHGB4	4.62e-04	80	65	3	10716726
Pubmed	Human and mouse proteases: a comparative genomic approach.	USP17L2 USP17L1 USP17L3	4.79e-04	81	65	3	12838346
Pubmed	ARHGEF18/p114RhoGEF Coordinates PKA/CREB Signaling and Actomyosin Remodeling to Promote Trophoblast Cell-Cell Fusion During Placenta Morphogenesis.	RHOXF2B RHOXF2	5.16e-04	18	65	2	33842485
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	MYCBP2 CDC16 CHD1 ZZEF1	6.79e-04	212	65	4	33853758
Pubmed	Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients.	HRNR FLG2	7.06e-04	21	65	2	19601998
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	PHF2 CUX2 MYCBP2 PHF8	8.48e-04	225	65	4	12168954
Pubmed	Nuclear localization of Prickle2 is required to establish cell polarity during early mouse embryogenesis.	LLGL1 PRICKLE1	9.24e-04	24	65	2	22333836
Pubmed	DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific manner.	RHOXF2B RHOXF2	9.24e-04	24	65	2	17182866
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	LLGL1 WDR11 ZNF395 RAPGEF2	9.50e-04	232	65	4	25515538
Interaction	PCDHGB3 interactions	PCDHGB5 PCDHGB1 PCDHGB4	1.69e-06	8	64	3	int:PCDHGB3
Cytoband	5q31	PCDHGB5 PCDHGB1 PCDHGB4	5.97e-04	115	65	3	5q31
Cytoband	8p23.1	USP17L2 USP17L1 USP17L3	1.39e-03	154	65	3	8p23.1
Cytoband	13q34	CDC16 ANKRD10	2.69e-03	54	65	2	13q34
Cytoband	Xq24	RHOXF2B RHOXF2	3.76e-03	64	65	2	Xq24
Cytoband	Ensembl 112 genes in cytogenetic band chr8p23	USP17L2 USP17L1 USP17L3	4.52e-03	234	65	3	chr8p23
Cytoband	7q36.1	CRYGN SSPOP	4.99e-03	74	65	2	7q36.1
Cytoband	Ensembl 112 genes in cytogenetic band chrXq24	RHOXF2B RHOXF2	5.95e-03	81	65	2	chrXq24
GeneFamily	Chitinases	CHI3L1 CHIT1	1.69e-04	7	52	2	816
GeneFamily	EF-hand domain containing\|S100 fused type protein family	HRNR FLG2	1.69e-04	7	52	2	1350
GeneFamily	Clustered protocadherins	PCDHGB5 PCDHGB1 PCDHGB4	8.26e-04	64	52	3	20
GeneFamily	Protein phosphatases, Mg2+/Mn2+ dependent	PPM1H PPM1A	1.07e-03	17	52	2	701
GeneFamily	PHD finger proteins\|Lysine demethylases	PHF2 PHF8	2.15e-03	24	52	2	485
Coexpression	MADAN_DPPA4_TARGETS	PLEKHG1 USP17L2 USP17L1 MYO1F USP17L3	2.39e-06	86	65	5	MM1312
Coexpression	MADAN_DPPA4_TARGETS	PLEKHG1 USP17L2 RHOXF2 MYO1F	1.72e-05	62	65	4	M2399
ToppCell	Adult-Immune-dendritic_cell-D175\|Adult / Lineage, Cell type, age group and donor	PLEKHG1 CUX2 GPR153 APCDD1L ABCA7	5.91e-06	176	65	5	1f0f1f953e6d61119f342de0d980aa1287511dba
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	KIAA0319 PLEKHG1 TSHZ3 PKD2L1 CHI3L1	7.14e-06	183	65	5	274076a0978bce2bd53a1732045f18ef0f2d9985
ToppCell	10x5'-GI_small-bowel-Myeloid_Dendritic-DC1\|GI_small-bowel / Manually curated celltypes from each tissue	SPI1 DLX4 TRIM6 PPM1H GGT5	7.53e-06	185	65	5	23ffba9216729b5bdb30b35742ba2627bb1200bf
ToppCell	3'-Child04-06-SmallIntestine-Hematopoietic-Myeloid-MMP9+_Inflammatory_macrophage\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SPI1 PKD2L1 CHI3L1 CHIT1 PPM1H	8.14e-06	188	65	5	fcf1bebef7aa81b4a11c1f9e4319339c290ecd22
ToppCell	Tracheal-10x3prime_v2-Immune_Myeloid-Macrophage_other-Macro_CHIT1\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	SPI1 PKD2L1 CHI3L1 CHIT1 GAA	1.07e-05	199	65	5	368e2bafae00ce8e9c6ea480f81b78f96b680acd
Disease	chitinase-3-like protein 1 measurement	CHI3L1 CHIT1	1.26e-05	3	61	2	EFO_0801470
Disease	mental development measurement	PCDHGB5 PCDHGB1 PCDHGB4	1.87e-05	25	61	3	EFO_0008230
Disease	level of chitinase-3-like protein 1 in blood serum	CHI3L1 CHIT1	2.52e-05	4	61	2	OBA_2041005
Disease	chitotriosidase-1 measurement	CHI3L1 CHIT1	6.27e-05	6	61	2	EFO_0008084
Disease	syndromic X-linked intellectual disability (implicated_via_orthology)	PHF2 PHF8	1.17e-04	8	61	2	DOID:0060309 (implicated_via_orthology)
Disease	primary ovarian insufficiency (implicated_via_orthology)	USP17L2 USP17L1 USP17L3	1.20e-04	46	61	3	DOID:5426 (implicated_via_orthology)
Disease	congenital heart disease (implicated_via_orthology)	USP17L2 USP17L1 USP17L3	4.00e-04	69	61	3	DOID:1682 (implicated_via_orthology)
Disease	YKL40 measurement	CHI3L1 CHIT1	4.34e-04	15	61	2	EFO_0004869
Disease	childhood trauma measurement, alcohol consumption measurement	PCDHGB5 PCDHGB1 PCDHGB4	4.35e-04	71	61	3	EFO_0007878, EFO_0007979
Disease	coronary artery disease	KIAA0319 PHF2 PLEKHG1 CUX2 CRYGN PKD2L1 CHST12 RAPGEF2 PPM1A	7.36e-04	1194	61	9	EFO_0001645
Disease	skin hydration measurement	PLEKHG1 FZD10	8.61e-04	21	61	2	EFO_0009586
Disease	Sarcosine measurement	PCDHGB1 PCDHGB4	1.03e-03	23	61	2	EFO_0021668
Disease	Hypermetropia	TSHZ3 KIF14 CHST12	1.28e-03	103	61	3	HP_0000540
Disease	hypertension, COVID-19	PLEKHG1 CUX2	1.43e-03	27	61	2	EFO_0000537, MONDO_0100096
Disease	diastolic blood pressure, unipolar depression	PLEKHG1 CUX2	1.76e-03	30	61	2	EFO_0003761, EFO_0006336

Protein segments in the cluster

Peptide	Gene	Start	Entry
PHAHLASEDSFYGWT	ANKRD10	46	Q9NXR5
GHSRSWEGYYHHFSD	APCDD1L	306	Q8NCL9
KSEIGDAGYFDHHWA	CUX2	776	O14529
DAGYFDHHWASDRGL	CUX2	781	O14529
LDDVYAKHWHSDSAG	CPO	341	Q8IVL8
YSSFSNGKDHRDWDH	CHD1	1576	O14646
SFGAWYQHHSSDVLA	DLX4	221	Q92988
SFYHWGAAVPHSQGD	ADAMTS13	466	Q76LX8
SGGYSWQDAHADVGH	ABCA7	381	Q8IZY2
HFDKNEHWSASDTGY	MMP26	186	Q9NRE1
AVDADSGHNAWLSYH	PCDHGB4	591	Q9UN71
HSDGSYAVWSVDAGS	LLGL1	256	Q15334
AYDFHGSWEKVTGHN	CHIT1	211	Q13231
STWGAGHFSTFDHHV	MUC6	46	Q6W4X9
HSSWSEGEEHGYSSG	FLG2	131	Q5D862
SFWSFDECHPHYASQ	KIF14	406	Q15058
AHYEFLWGSKAHAET	MAGEA9	266	P43362
EFYDSWHSKSTDYHG	MTMR12	611	Q9C0I1
YDFHGAWRGTTGHHS	CHI3L1	206	P36222
DADSGHNAWLSYHVL	PCDHGB1	591	Q9Y5G3
AVGWHDTSERFYTHG	GPR153	146	Q6NV75
FGHHESSSWQSSGYT	HRNR	1871	Q86YZ3
FGHHESSSWQSSGYT	HRNR	2341	Q86YZ3
DADSGHNAWLSYHVL	PCDHGB5	591	Q9Y5G0
HGDYPDFFRWNSHSD	CRYGN	66	Q8WXF5
TYDGQHWHATEACFS	PRICKLE1	266	Q96MT3
KWGHEAIEANSSYFH	FZD10	341	Q9ULW2
AWIAYGHSFAVESEH	CDC16	336	Q13042
GWYATGHDITEHSVL	EIF3F	171	O00303
YSLAEAWGHGTGTSH	GGT5	376	P36269
STFAGHGRYAGHWTG	GAA	601	P10253
AGSTWHAAGLTTYFH	DMGDH	86	Q9UI17
DESGDHTGWKIHYTS	MASP2	281	O00187
YGYSSGASSLHRHWG	DPEP1	381	P16444
SVEDHSGYNFPWSTH	CH25H	211	O95992
YGSTFAFHGSHIENW	PARP6	466	Q2NL67
HNEYALVSAWHSSGS	SZT2	3136	Q5T011
TDFHIDSGGASAWYH	PHF2	246	O75151
ASWSGFHYRTFDGRH	SSPOP	196	A2VEC9
RFESHGGGWGYSAHS	MYCBP2	1236	O75592
SGMRDDYFWDHSHSS	RHOXF2B	226	P0C7M4
SDGESHSDHYWDFHP	SPI1	41	P17947
HNDASDHGCSRWGYF	SLC39A6	711	Q13433
WDSAGAAHFYLHTSF	CHST12	26	Q9NRB3
HTHFDYSGDPAGLWA	RAPGEF2	1276	Q9Y4G8
AGWSCHDGHYFSYVK	USP17L3	326	A6NCW0
YWHGVSFHDNDIFSG	TTLL11	256	Q8NHH1
YAGLFSWDEVHHNDA	ARHGAP40	331	Q5TG30
YSGGHDSSSWSHRYG	RBMXL3	611	Q8N7X1
GVSCHYWSLFDGHAG	PPM1H	141	Q9ULR3
YWSLFDGHAGSGAAV	PPM1H	146	Q9ULR3
ESWSFFAVYDGHAGS	PPM1A	51	P35813
EHWHYISFGLSDLYG	SUFU	86	Q9UMX1
SAPGSFWHIQADHAY	ZNF395	396	Q9H8N7
SGMRDDYFWDHSHSS	RHOXF2	226	Q9BQY4
YYSGHTHGTGEWALA	TMEM168	501	Q9H0V1
AGWSCHDGHYFSYVK	USP17L1	326	Q7RTZ2
TYHSQDELGGFSHWG	PKD2L1	246	Q9P0L9
YGHQNGASYAWHFEA	TSHZ3	366	Q63HK5
HSDSSHNEWGYKFTV	ZZEF1	1176	O43149
DFHIDFGGTSVWYHV	PHF8	281	Q9UPP1
VHHGSGDWLLHSTYS	PLEKHG1	1076	Q9ULL1
GDESELHFWTVAAHY	WDR11	921	Q9BZH6
AGWSCHDGHYFSYVK	USP17L2	326	Q6R6M4
GSQHFSSGKHYWEVD	TRIM6	346	Q9C030
HKYDHSEATGSSSWD	ZNF32	31	P17041
GSSSSDDHGIVFYHW	KIAA0319	646	Q5VV43
AVGTHEHFNSWSAGF	MYO1F	486	O00160