Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	toxin transmembrane transporter activity	LRP6 LRP5	1.43e-04	12	30	2	GO:0019534
GeneOntologyMolecularFunction	neurexin family protein binding	NLGN4X NLGN4Y	2.58e-04	16	30	2	GO:0042043
GeneOntologyMolecularFunction	low-density lipoprotein particle receptor activity	LRP2 LRP6	2.58e-04	16	30	2	GO:0005041
GeneOntologyMolecularFunction	chloride ion binding	NLGN4X NLGN4Y	2.58e-04	16	30	2	GO:0031404
GeneOntologyMolecularFunction	Wnt receptor activity	LRP6 LRP5	2.93e-04	17	30	2	GO:0042813
GeneOntologyMolecularFunction	lipoprotein particle receptor activity	LRP2 LRP6	4.50e-04	21	30	2	GO:0030228
GeneOntologyMolecularFunction	Wnt-protein binding	LRP6 LRP5	1.19e-03	34	30	2	GO:0017147
GeneOntologyMolecularFunction	protein tyrosine kinase activity	NRG2 BCR EPHA10	1.32e-03	145	30	3	GO:0004713
GeneOntologyMolecularFunction	protein kinase activity	NRG2 MAST1 BCR PRAG1 EPHA10	1.84e-03	600	30	5	GO:0004672
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	NRG2 MAST1 BCR PRAG1 EPHA10	3.79e-03	709	30	5	GO:0016773
GeneOntologyMolecularFunction	transmembrane receptor protein tyrosine kinase activity	NRG2 EPHA10	4.28e-03	65	30	2	GO:0004714
GeneOntologyMolecularFunction	kinase activity	NRG2 MAST1 BCR PRAG1 EPHA10	5.21e-03	764	30	5	GO:0016301
GeneOntologyMolecularFunction	coreceptor activity	LRP6 LRP5	5.22e-03	72	30	2	GO:0015026
GeneOntologyBiologicalProcess	territorial aggressive behavior	NLGN4X NLGN4Y	6.13e-06	3	30	2	GO:0002124
GeneOntologyBiologicalProcess	male courtship behavior	NLGN4X NLGN4Y	1.22e-05	4	30	2	GO:0008049
GeneOntologyBiologicalProcess	Norrin signaling pathway	LRP6 LRP5	2.04e-05	5	30	2	GO:0110135
GeneOntologyBiologicalProcess	establishment of blood-retinal barrier	LRP6 LRP5	3.06e-05	6	30	2	GO:1990963
GeneOntologyBiologicalProcess	courtship behavior	NLGN4X NLGN4Y	4.28e-05	7	30	2	GO:0007619
GeneOntologyBiologicalProcess	cell junction organization	NRG2 LRP5 IGSF9 NLGN4X BCR NLGN4Y AJM1 SYNGAP1	5.55e-05	974	30	8	GO:0034330
GeneOntologyBiologicalProcess	brainstem development	NLGN4X NLGN4Y	5.70e-05	8	30	2	GO:0003360
GeneOntologyBiologicalProcess	postsynaptic membrane organization	LRP5 NLGN4X NLGN4Y	7.31e-05	56	30	3	GO:0001941
GeneOntologyBiologicalProcess	mesodermal cell migration	LRP6 LRP5	7.32e-05	9	30	2	GO:0008078
GeneOntologyBiologicalProcess	presynaptic membrane assembly	NLGN4X NLGN4Y	9.14e-05	10	30	2	GO:0097105
GeneOntologyBiologicalProcess	postsynaptic membrane assembly	NLGN4X NLGN4Y	1.12e-04	11	30	2	GO:0097104
GeneOntologyBiologicalProcess	endocytosis	LRP2 EHBP1 LRP6 LRP5 NLGN4X BCR NLGN4Y	1.47e-04	827	30	7	GO:0006897
GeneOntologyBiologicalProcess	aggressive behavior	NLGN4X NLGN4Y	1.58e-04	13	30	2	GO:0002118
GeneOntologyBiologicalProcess	presynaptic membrane organization	NLGN4X NLGN4Y	1.58e-04	13	30	2	GO:0097090
GeneOntologyBiologicalProcess	male mating behavior	NLGN4X NLGN4Y	2.12e-04	15	30	2	GO:0060179
GeneOntologyBiologicalProcess	neuron cell-cell adhesion	NLGN4X NLGN4Y	2.42e-04	16	30	2	GO:0007158
GeneOntologyBiologicalProcess	establishment of blood-brain barrier	LRP6 LRP5	3.44e-04	19	30	2	GO:0060856
GeneOntologyBiologicalProcess	cell migration involved in gastrulation	LRP6 LRP5	3.82e-04	20	30	2	GO:0042074
GeneOntologyBiologicalProcess	synapse organization	NRG2 LRP5 IGSF9 NLGN4X NLGN4Y SYNGAP1	3.94e-04	685	30	6	GO:0050808
GeneOntologyBiologicalProcess	vocalization behavior	NLGN4X NLGN4Y	5.53e-04	24	30	2	GO:0071625
GeneOntologyBiologicalProcess	import into cell	LRP2 EHBP1 LRP6 LRP5 NLGN4X BCR NLGN4Y	7.21e-04	1074	30	7	GO:0098657
GeneOntologyBiologicalProcess	bone morphogenesis	LRP6 LRP5 PAX1	7.65e-04	124	30	3	GO:0060349
GeneOntologyBiologicalProcess	branching involved in mammary gland duct morphogenesis	LRP6 LRP5	8.67e-04	30	30	2	GO:0060444
GeneOntologyBiologicalProcess	pattern specification process	LRP2 LRP6 LRP5 PAX1 SYNGAP1	8.90e-04	526	30	5	GO:0007389
GeneOntologyBiologicalProcess	postsynapse organization	LRP5 NLGN4X NLGN4Y SYNGAP1	1.04e-03	313	30	4	GO:0099173
GeneOntologyBiologicalProcess	cerebellum development	LRP6 NLGN4X NLGN4Y	1.06e-03	139	30	3	GO:0021549
GeneOntologyBiologicalProcess	gastrulation with mouth forming second	LRP6 LRP5	1.18e-03	35	30	2	GO:0001702
GeneOntologyBiologicalProcess	axonogenesis	LRP2 IGSF9 MAP6 EPHA10 SYNGAP1	1.23e-03	566	30	5	GO:0007409
GeneOntologyBiologicalProcess	positive regulation of mesenchymal cell proliferation	LRP6 LRP5	1.25e-03	36	30	2	GO:0002053
GeneOntologyBiologicalProcess	brain development	LRP2 MAST1 LRP6 NLGN4X BCR NLGN4Y	1.29e-03	859	30	6	GO:0007420
GeneOntologyBiologicalProcess	cell morphogenesis	LRP2 LRP6 IGSF9 MAP6 PRAG1 EPHA10 SYNGAP1	1.34e-03	1194	30	7	GO:0000902
GeneOntologyBiologicalProcess	central nervous system development	LRP2 MAST1 LRP6 LRP5 NLGN4X BCR NLGN4Y	1.36e-03	1197	30	7	GO:0007417
GeneOntologyBiologicalProcess	metencephalon development	LRP6 NLGN4X NLGN4Y	1.40e-03	153	30	3	GO:0022037
GeneOntologyBiologicalProcess	head development	LRP2 MAST1 LRP6 NLGN4X BCR NLGN4Y	1.82e-03	919	30	6	GO:0060322
GeneOntologyBiologicalProcess	regulation of nervous system development	LRP2 LRP6 SPEN MAP6 SYNGAP1	1.91e-03	625	30	5	GO:0051960
GeneOntologyBiologicalProcess	regulation of mesenchymal cell proliferation	LRP6 LRP5	1.95e-03	45	30	2	GO:0010464
GeneOntologyBiologicalProcess	mammary gland duct morphogenesis	LRP6 LRP5	1.95e-03	45	30	2	GO:0060603
GeneOntologyCellularComponent	dendrite	LRP2 MAST1 IGSF9 NLGN4X BCR MAP6 NLGN4Y EPHA10 SYNGAP1	2.08e-06	858	30	9	GO:0030425
GeneOntologyCellularComponent	dendritic tree	LRP2 MAST1 IGSF9 NLGN4X BCR MAP6 NLGN4Y EPHA10 SYNGAP1	2.12e-06	860	30	9	GO:0097447
GeneOntologyCellularComponent	somatodendritic compartment	LRP2 MAST1 LRP6 IGSF9 NLGN4X BCR MAP6 NLGN4Y EPHA10 SYNGAP1	4.80e-06	1228	30	10	GO:0036477
GeneOntologyCellularComponent	inhibitory synapse	IGSF9 NLGN4X NLGN4Y	1.17e-05	31	30	3	GO:0060077
GeneOntologyCellularComponent	symmetric, GABA-ergic, inhibitory synapse	NLGN4X NLGN4Y	1.19e-05	4	30	2	GO:0098983
GeneOntologyCellularComponent	Wnt-Frizzled-LRP5/6 complex	LRP6 LRP5	1.99e-05	5	30	2	GO:1990851
GeneOntologyCellularComponent	symmetric synapse	NLGN4X NLGN4Y	1.54e-04	13	30	2	GO:0032280
GeneOntologyCellularComponent	Wnt signalosome	LRP6 LRP5	2.36e-04	16	30	2	GO:1990909
GeneOntologyCellularComponent	glycinergic synapse	NLGN4X NLGN4Y	3.72e-04	20	30	2	GO:0098690
GeneOntologyCellularComponent	asymmetric, glutamatergic, excitatory synapse	NLGN4X NLGN4Y	5.39e-04	24	30	2	GO:0098985
GeneOntologyCellularComponent	GABA-ergic synapse	NRG2 NLGN4X NLGN4Y	1.65e-03	164	30	3	GO:0098982
GeneOntologyCellularComponent	postsynaptic density, intracellular component	BCR SYNGAP1	2.25e-03	49	30	2	GO:0099092
GeneOntologyCellularComponent	postsynaptic specialization, intracellular component	BCR SYNGAP1	2.92e-03	56	30	2	GO:0099091
GeneOntologyCellularComponent	postsynaptic density	NLGN4X BCR NLGN4Y SYNGAP1	3.76e-03	451	30	4	GO:0014069
GeneOntologyCellularComponent	asymmetric synapse	NLGN4X BCR NLGN4Y SYNGAP1	4.58e-03	477	30	4	GO:0032279
GeneOntologyCellularComponent	postsynaptic specialization	NLGN4X BCR NLGN4Y SYNGAP1	5.53e-03	503	30	4	GO:0099572
GeneOntologyCellularComponent	glutamatergic synapse	NRG2 NLGN4X BCR NLGN4Y SYNGAP1	5.70e-03	817	30	5	GO:0098978
GeneOntologyCellularComponent	neuron to neuron synapse	NLGN4X BCR NLGN4Y SYNGAP1	6.34e-03	523	30	4	GO:0098984
GeneOntologyCellularComponent	axon	LRP2 MAST1 IGSF9 BCR MAP6	8.17e-03	891	30	5	GO:0030424
Domain	Ldl_recept_b	LRP2 LRP6 LRP5	1.21e-06	14	29	3	PF00058
Domain	LDLRB	LRP2 LRP6 LRP5	1.21e-06	14	29	3	PS51120
Domain	EGF	LRP2 NRG2 LRP6 LRP5 ZAN	1.35e-06	126	29	5	PF00008
Domain	LY	LRP2 LRP6 LRP5	1.51e-06	15	29	3	SM00135
Domain	LDLR_classB_rpt	LRP2 LRP6 LRP5	1.51e-06	15	29	3	IPR000033
Domain	NLGN4	NLGN4X NLGN4Y	2.33e-06	2	29	2	IPR030025
Domain	LRP5/6	LRP6 LRP5	2.33e-06	2	29	2	IPR017049
Domain	EGF-like_CS	LRP2 NRG2 LRP6 LRP5 ZAN EPHA10	2.55e-06	261	29	6	IPR013032
Domain	EGF_2	LRP2 NRG2 LRP6 LRP5 ZAN EPHA10	2.78e-06	265	29	6	PS01186
Domain	Nlgn	NLGN4X NLGN4Y	2.32e-05	5	29	2	IPR000460
Domain	EGF_3	LRP2 NRG2 LRP6 LRP5 ZAN	2.80e-05	235	29	5	PS50026
Domain	EGF	LRP2 NRG2 LRP6 LRP5 ZAN	2.80e-05	235	29	5	SM00181
Domain	-	LRP2 LRP6 LRP5	2.96e-05	39	29	3	2.120.10.30
Domain	LDLR_class-A_CS	LRP2 LRP6 LRP5	3.20e-05	40	29	3	IPR023415
Domain	EGF-like_dom	LRP2 NRG2 LRP6 LRP5 ZAN	3.70e-05	249	29	5	IPR000742
Domain	EGF_1	LRP2 NRG2 LRP6 LRP5 ZAN	4.14e-05	255	29	5	PS00022
Domain	Ldl_recept_a	LRP2 LRP6 LRP5	4.57e-05	45	29	3	PF00057
Domain	-	LRP2 LRP6 LRP5	4.88e-05	46	29	3	4.10.400.10
Domain	6-blade_b-propeller_TolB-like	LRP2 LRP6 LRP5	4.88e-05	46	29	3	IPR011042
Domain	LDLRA_1	LRP2 LRP6 LRP5	5.55e-05	48	29	3	PS01209
Domain	LDrepeatLR_classA_rpt	LRP2 LRP6 LRP5	5.91e-05	49	29	3	IPR002172
Domain	LDLa	LRP2 LRP6 LRP5	5.91e-05	49	29	3	SM00192
Domain	LDLRA_2	LRP2 LRP6 LRP5	5.91e-05	49	29	3	PS50068
Domain	Carboxylesterase_B_CS	NLGN4X NLGN4Y	1.80e-04	13	29	2	IPR019819
Domain	COesterase	NLGN4X NLGN4Y	2.09e-04	14	29	2	PF00135
Domain	CARBOXYLESTERASE_B_2	NLGN4X NLGN4Y	2.09e-04	14	29	2	PS00941
Domain	CarbesteraseB	NLGN4X NLGN4Y	2.09e-04	14	29	2	IPR002018
Domain	TIL_dom	LRP2 ZAN	2.09e-04	14	29	2	IPR002919
Domain	C2_dom	TNS2 BCR SYNGAP1	2.05e-03	164	29	3	IPR000008
Domain	-	TNS2 BCR PLEKHH3 SYNGAP1	2.97e-03	391	29	4	2.30.29.30
Domain	PH_dom-like	TNS2 BCR PLEKHH3 SYNGAP1	4.03e-03	426	29	4	IPR011993
Domain	Rho_GTPase_activation_prot	BCR SYNGAP1	8.20e-03	88	29	2	IPR008936
Domain	PH	BCR PLEKHH3 SYNGAP1	8.96e-03	278	29	3	SM00233
Domain	PH_DOMAIN	BCR PLEKHH3 SYNGAP1	9.04e-03	279	29	3	PS50003
Domain	PH_domain	BCR PLEKHH3 SYNGAP1	9.13e-03	280	29	3	IPR001849
Domain	PROTEIN_KINASE_TYR	PRAG1 EPHA10	9.89e-03	97	29	2	PS00109
Domain	Tyr_kinase_AS	PRAG1 EPHA10	9.89e-03	97	29	2	IPR008266
Domain	EGF_CA	LRP2 LRP5	1.03e-02	99	29	2	PS01187
Pathway	WP_WNTBETACATENIN_SIGNALING_INHIBITORS_IN_CURRENT_AND_PAST_CLINICAL_TRIALS	LRP6 LRP5	1.37e-05	5	17	2	M48304
Pathway	REACTOME_NEGATIVE_REGULATION_OF_TCF_DEPENDENT_SIGNALING_BY_WNT_LIGAND_ANTAGONISTS	LRP6 LRP5	3.82e-05	8	17	2	MM14976
Pathway	REACTOME_SIGNALING_BY_RNF43_MUTANTS	LRP6 LRP5	3.82e-05	8	17	2	M27433
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_SOST_LRP4	LRP6 LRP5	1.24e-04	14	17	2	M47834
Pathway	REACTOME_NEGATIVE_REGULATION_OF_TCF_DEPENDENT_SIGNALING_BY_WNT_LIGAND_ANTAGONISTS	LRP6 LRP5	1.42e-04	15	17	2	M27273
Pathway	REACTOME_REGULATION_OF_FZD_BY_UBIQUITINATION	LRP6 LRP5	2.57e-04	20	17	2	MM15155
Pathway	REACTOME_REGULATION_OF_FZD_BY_UBIQUITINATION	LRP6 LRP5	2.84e-04	21	17	2	M27401
Pathway	WP_WNTBETACATENIN_SIGNALING_IN_LEUKEMIA	LRP6 LRP5	4.37e-04	26	17	2	M39407
Pathway	PID_WNT_SIGNALING_PATHWAY	LRP6 LRP5	5.08e-04	28	17	2	M77
Pathway	REACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE	LRP6 LRP5	6.24e-04	31	17	2	M27400
Pathway	REACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE	LRP6 LRP5	6.24e-04	31	17	2	MM15154
Pathway	REACTOME_NEUREXINS_AND_NEUROLIGINS	NLGN4X NLGN4Y	6.65e-04	32	17	2	MM15326
Pathway	WP_DISRUPTION_OF_POSTSYNAPTIC_SIGNALING_BY_CNV	NLGN4X SYNGAP1	7.07e-04	33	17	2	M39875
Pathway	WP_TYPE_I_COLLAGEN_SYNTHESIS_IN_THE_CONTEXT_OF_OSTEOGENESIS_IMPERFECTA	LRP6 LRP5	7.07e-04	33	17	2	M39870
Pathway	REACTOME_SIGNALING_BY_WNT_IN_CANCER	LRP6 LRP5	7.51e-04	34	17	2	M27405
Pathway	WP_WNT_SIGNALING_IN_KIDNEY_DISEASE	LRP6 LRP5	8.42e-04	36	17	2	M39699
Pathway	KEGG_MEDICUS_VARIANT_FZD7_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY	LRP6 LRP5	8.89e-04	37	17	2	M47411
Pathway	WP_FATTY_ACIDS_AND_LIPOPROTEINS_TRANSPORT_IN_HEPATOCYTES	LRP2 EHBP1 LRP6 LRP5	9.45e-04	381	17	4	M48063
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_PATHWAY	LRP6 LRP5	1.37e-03	46	17	2	M47409
Pathway	WP_RETT_SYNDROME	HIVEP2 SYNGAP1	1.49e-03	48	17	2	M39759
Pathway	WP_WNT_SIGNALING_WP363	LRP6 LRP5	1.69e-03	51	17	2	M39721
Pathway	REACTOME_DISEASES_OF_SIGNAL_TRANSDUCTION_BY_GROWTH_FACTOR_RECEPTORS_AND_SECOND_MESSENGERS	NRG2 LRP6 LRP5 BCR	1.96e-03	464	17	4	M27547
Pathway	REACTOME_NEUREXINS_AND_NEUROLIGINS	NLGN4X NLGN4Y	2.03e-03	56	17	2	M27616
Pathway	REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES	NLGN4X NLGN4Y	2.89e-03	67	17	2	MM15327
Pathway	WP_PRIMARY_FOCAL_SEGMENTAL_GLOMERULOSCLEROSIS_FSGS	LRP6 LRP5	3.33e-03	72	17	2	M39403
Pathway	WP_PRIMARY_FOCAL_SEGMENTAL_GLOMERULOSCLEROSIS_FSGS	LRP6 LRP5	3.42e-03	73	17	2	MM15906
Pathway	REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES	NLGN4X NLGN4Y	4.82e-03	87	17	2	M27617
Pathway	WP_NCRNAS_INVOLVED_IN_WNT_SIGNALING_IN_HEPATOCELLULAR_CARCINOMA	LRP6 LRP5	5.04e-03	89	17	2	M39563
Pathway	WNT_SIGNALING	LRP6 LRP5	5.04e-03	89	17	2	M5493
Pathway	WP_LNCRNA_IN_CANONICAL_WNT_SIGNALING_AND_COLORECTAL_CANCER	LRP6 LRP5	6.08e-03	98	17	2	M39731
Pathway	WP_MICRORNAS_IN_CARDIOMYOCYTE_HYPERTROPHY	LRP6 LRP5	6.20e-03	99	17	2	MM15905
Pathway	WP_WNT_SIGNALING_PATHWAY_AND_PLURIPOTENCY	LRP6 LRP5	6.44e-03	101	17	2	MM15829
Pathway	WP_WNT_SIGNALING_AND_PLURIPOTENCY	LRP6 LRP5	6.44e-03	101	17	2	M39387
Pathway	WP_MICRORNAS_IN_CARDIOMYOCYTE_HYPERTROPHY	LRP6 LRP5	6.82e-03	104	17	2	M39625
Pathway	WP_WNT_SIGNALING_PATHWAY	LRP6 LRP5	7.60e-03	110	17	2	MM15977
Pathway	WP_WNT_SIGNALING_WP428	LRP6 LRP5	8.01e-03	113	17	2	M39669
Pathway	WP_ESC_PLURIPOTENCY_PATHWAYS	LRP6 LRP5	8.42e-03	116	17	2	MM15863
Pathway	WP_EMBRYONIC_STEM_CELL_PLURIPOTENCY_PATHWAYS	LRP6 LRP5	8.56e-03	117	17	2	M39530
Pathway	WP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES	LRP6 LRP5	8.70e-03	118	17	2	M39852
Pubmed	LRP2 mediates folate uptake in the developing neural tube.	LRP2 LRP6 LRP5	9.51e-08	11	30	3	24639464
Pubmed	Absence of deficits in social behaviors and ultrasonic vocalizations in later generations of mice lacking neuroligin4.	NLGN4X NLGN4Y	7.19e-07	2	30	2	22989184
Pubmed	Gene targeting approaches in mice: assessing the roles of LRP5 and LRP6 in osteoblasts.	LRP6 LRP5	7.19e-07	2	30	2	19147944
Pubmed	LRP5/6 directly bind to Frizzled and prevent Frizzled-regulated tumour metastasis.	LRP6 LRP5	7.19e-07	2	30	2	25902418
Pubmed	Wnt-Lrp5 signaling regulates fatty acid metabolism in the osteoblast.	LRP6 LRP5	7.19e-07	2	30	2	25802278
Pubmed	Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6.	LRP6 LRP5	7.19e-07	2	30	2	15537447
Pubmed	Distinct roles of LRP5 and LRP6 in Wnt signaling regulation in the retina.	LRP6 LRP5	7.19e-07	2	30	2	33545636
Pubmed	LRP5 and LRP6 are not required for protective antigen-mediated internalization or lethality of anthrax lethal toxin.	LRP6 LRP5	7.19e-07	2	30	2	17335347
Pubmed	Evidence against a human cell-specific role for LRP6 in anthrax toxin entry.	LRP6 LRP5	7.19e-07	2	30	2	18350154
Pubmed	Unusually rapid evolution of Neuroligin-4 in mice.	NLGN4X NLGN4Y	7.19e-07	2	30	2	18434543
Pubmed	Autism Related Neuroligin-4 Knockout Impairs Intracortical Processing but not Sensory Inputs in Mouse Barrel Cortex.	NLGN4X NLGN4Y	7.19e-07	2	30	2	29106499
Pubmed	Perturbed Hippocampal Synaptic Inhibition and γ-Oscillations in a Neuroligin-4 Knockout Mouse Model of Autism.	NLGN4X NLGN4Y	7.19e-07	2	30	2	26456829
Pubmed	Nlgn4 knockout induces network hypo-excitability in juvenile mouse somatosensory cortex in vitro.	NLGN4X NLGN4Y	7.19e-07	2	30	2	24104404
Pubmed	Clinical Phenotype and Relevance of LRP5 and LRP6 Variants in Patients With Early-Onset Osteoporosis (EOOP).	LRP6 LRP5	7.19e-07	2	30	2	33118644
Pubmed	Lrp5 and Lrp6 are required for maintaining self-renewal and differentiation of hematopoietic stem cells.	LRP6 LRP5	7.19e-07	2	30	2	30668923
Pubmed	Dissecting molecular differences between Wnt coreceptors LRP5 and LRP6.	LRP6 LRP5	7.19e-07	2	30	2	21887268
Pubmed	Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density.	LRP6 LRP5	7.19e-07	2	30	2	12579474
Pubmed	The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development.	LRP6 LRP5	7.19e-07	2	30	2	19503830
Pubmed	Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism.	NLGN4X NLGN4Y	7.19e-07	2	30	2	23183221
Pubmed	Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts.	LRP6 LRP5	7.19e-07	2	30	2	22433869
Pubmed	PAR1&2 driven placenta EVT invasion act via LRP5/6 as coreceptors.	LRP6 LRP5	7.19e-07	2	30	2	33136328
Pubmed	Juvenile manifestation of ultrasound communication deficits in the neuroligin-4 null mutant mouse model of autism.	NLGN4X NLGN4Y	7.19e-07	2	30	2	24855039
Pubmed	Co-deletion of Lrp5 and Lrp6 in the skeleton severely diminishes bone gain from sclerostin antibody administration.	LRP6 LRP5	7.19e-07	2	30	2	33164872
Pubmed	LRP5-/6 gene polymorphisms and its association with risk of abnormal bone mass in postmenopausal women.	LRP6 LRP5	7.19e-07	2	30	2	37202775
Pubmed	Lack of association of LRP5 and LRP6 polymorphisms with type 2 diabetes mellitus in the Japanese population.	LRP6 LRP5	7.19e-07	2	30	2	18493104
Pubmed	Wnt receptors, bone mass, and fractures: gene-wide association analysis of LRP5 and LRP6 polymorphisms with replication.	LRP6 LRP5	7.19e-07	2	30	2	20926594
Pubmed	Common genetic variation of the low-density lipoprotein receptor-related protein 5 and 6 genes determines fracture risk in elderly white men.	LRP6 LRP5	7.19e-07	2	30	2	16355283
Pubmed	Sex-specific microglia state in the Neuroligin-4 knock-out mouse model of autism spectrum disorder.	NLGN4X NLGN4Y	7.19e-07	2	30	2	37001827
Pubmed	A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y.	NLGN4X NLGN4Y	7.19e-07	2	30	2	32243781
Pubmed	The involvement of the canonical Wnt-signaling receptor LRP5 and LRP6 gene variants with ADHD and sexual dimorphism: Association study and meta-analysis.	LRP6 LRP5	7.19e-07	2	30	2	30474181
Pubmed	LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way.	LRP6 LRP5	7.19e-07	2	30	2	15084453
Pubmed	Haemorrhagic snake venom metalloproteases and human ADAMs cleave LRP5/6, which disrupts cell-cell adhesions in vitro and induces haemorrhage in vivo.	LRP6 LRP5	7.19e-07	2	30	2	28425175
Pubmed	Increased Network Inhibition in the Dentate Gyrus of Adult Neuroligin-4 Knock-Out Mice.	NLGN4X NLGN4Y	7.19e-07	2	30	2	37080762
Pubmed	In Adult Skeletal Muscles, the Co-Receptors of Canonical Wnt Signaling, Lrp5 and Lrp6, Determine the Distribution and Size of Fiber Types, and Structure and Function of Neuromuscular Junctions.	LRP6 LRP5	7.19e-07	2	30	2	36552732
Pubmed	Idiopathic Juvenile Osteoporosis: Clinical Experience from a Single Centre and Screening of LRP5 and LRP6 Genes.	LRP6 LRP5	7.19e-07	2	30	2	25783012
Pubmed	MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.	LRP2 LRP6 LRP5	7.62e-07	21	30	3	21337463
Pubmed	Canonical Wnt Signaling in CD11c+ APCs Regulates Microbiota-Induced Inflammation and Immune Cell Homeostasis in the Colon.	LRP6 LRP5	2.16e-06	3	30	2	29602775
Pubmed	The structural basis of DKK-mediated inhibition of Wnt/LRP signaling.	LRP6 LRP5	2.16e-06	3	30	2	22589387
Pubmed	Radiographic osteoarthritis at three joint sites and FRZB, LRP5, and LRP6 polymorphisms in two population-based cohorts.	LRP6 LRP5	2.16e-06	3	30	2	18406176
Pubmed	Analysis of the neuroligin 4Y gene in patients with autism.	NLGN4X NLGN4Y	2.16e-06	3	30	2	18628683
Pubmed	Wnt co-receptor LRP5/6 overexpression confers protection against hydrogen peroxide-induced neurotoxicity and reduces tau phosphorylation in SH-SY5Y cells.	LRP6 LRP5	2.16e-06	3	30	2	25959626
Pubmed	Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells.	LRP6 LRP5	2.16e-06	3	30	2	30664649
Pubmed	Opposing Roles of Wnt Inhibitors IGFBP-4 and Dkk1 in Cardiac Ischemia by Differential Targeting of LRP5/6 and β-catenin.	LRP6 LRP5	2.16e-06	3	30	2	27803037
Pubmed	Molecular simulation analysis of the structure complex of C2 domains of DKK family members and β-propeller domains of LRP5/6: explaining why DKK3 does not bind to LRP5/6.	LRP6 LRP5	2.16e-06	3	30	2	24743782
Pubmed	Peptide-based mediated disruption of N-cadherin-LRP5/6 interaction promotes Wnt signaling and bone formation.	LRP6 LRP5	2.16e-06	3	30	2	22576936
Pubmed	Neuroligin-4 is localized to glycinergic postsynapses and regulates inhibition in the retina.	NLGN4X NLGN4Y	2.16e-06	3	30	2	21282647
Pubmed	Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/6.	LRP6 LRP5	2.16e-06	3	30	2	21397183
Pubmed	Multivesicular GSK3 sequestration upon Wnt signaling is controlled by p120-catenin/cadherin interaction with LRP5/6.	LRP6 LRP5	2.16e-06	3	30	2	24412065
Pubmed	LRP5 in premature adrenarche and in metabolic characteristics of prepubertal children.	LRP6 LRP5	2.16e-06	3	30	2	18721193
Pubmed	tPA regulates neurite outgrowth by phosphorylation of LRP5/6 in neural progenitor cells.	LRP6 LRP5	2.16e-06	3	30	2	23925701
Pubmed	Depletion of canonical Wnt signaling components has a neuroprotective effect on midbrain dopaminergic neurons in an MPTP-induced mouse model of Parkinson's disease.	LRP6 LRP5	2.16e-06	3	30	2	25009587
Pubmed	Structural insight into the mechanisms of Wnt signaling antagonism by Dkk.	LRP6 LRP5	2.16e-06	3	30	2	18524778
Pubmed	Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6.	LRP6 LRP5	2.16e-06	3	30	2	22000856
Pubmed	TRAP1 Regulates Wnt/β-Catenin Pathway through LRP5/6 Receptors Expression Modulation.	LRP6 LRP5	2.16e-06	3	30	2	33065966
Pubmed	Loss of endothelial glucocorticoid receptor promotes angiogenesis via upregulation of Wnt/β-catenin pathway.	LRP6 LRP5	2.16e-06	3	30	2	33650028
Pubmed	Evolution of the Autism-Associated Neuroligin-4 Gene Reveals Broad Erosion of Pseudoautosomal Regions in Rodents.	NLGN4X NLGN4Y	2.16e-06	3	30	2	32011705
Pubmed	Lrp5 and Lrp6 play compensatory roles in mouse intestinal development.	LRP6 LRP5	2.16e-06	3	30	2	21866564
Pubmed	Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation.	LRP6 LRP5	2.16e-06	3	30	2	25710911
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	EHBP1 MAST1 LRP5 IGSF9 VGLL4 HIVEP2 BCR INTS8 NLGN4Y	2.98e-06	1489	30	9	28611215
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	NLGN4X MAP6 PRAG1 NLGN4Y SYNGAP1	4.01e-06	281	30	5	28706196
Pubmed	The Wnt-β-Catenin-IL-10 Signaling Axis in Intestinal APCs Protects Mice from Colitis-Associated Colon Cancer in Response to Gut Microbiota.	LRP6 LRP5	4.31e-06	4	30	2	32917787
Pubmed	Ultrasonic vocalizations in mouse models for speech and socio-cognitive disorders: insights into the evolution of vocal communication.	NLGN4X NLGN4Y	4.31e-06	4	30	2	20579107
Pubmed	The role of Lrp5/6 in cardiac valve disease: experimental hypercholesterolemia in the ApoE-/- /Lrp5-/- mice.	LRP6 LRP5	4.31e-06	4	30	2	21678468
Pubmed	Oligomerization of Frizzled and LRP5/6 protein initiates intracellular signaling for the canonical WNT/β-catenin pathway.	LRP6 LRP5	4.31e-06	4	30	2	30361437
Pubmed	Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of Wnt co-receptors.	LRP6 LRP5	4.31e-06	4	30	2	22696217
Pubmed	Critical Endothelial Regulation by LRP5 during Retinal Vascular Development.	LRP6 LRP5	4.31e-06	4	30	2	27031698
Pubmed	Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins.	LRP6 LRP5	4.31e-06	4	30	2	15064719
Pubmed	Differential expression of DKK-1 binding receptors on stromal cells and myeloma cells results in their distinct response to secreted DKK-1 in myeloma.	LRP6 LRP5	4.31e-06	4	30	2	20846389
Pubmed	Characterization of the Kremen-binding site on Dkk1 and elucidation of the role of Kremen in Dkk-mediated Wnt antagonism.	LRP6 LRP5	4.31e-06	4	30	2	18502762
Pubmed	Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow.	LRP6 LRP5	4.31e-06	4	30	2	11433302
Pubmed	Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts.	LRP6 LRP5	4.31e-06	4	30	2	29176883
Pubmed	Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function.	LRP6 LRP5	4.31e-06	4	30	2	21471202
Pubmed	Analysis of four neuroligin genes as candidates for autism.	NLGN4X NLGN4Y	4.31e-06	4	30	2	16077734
Pubmed	Identification of the low density lipoprotein receptor-related protein (LRP) as an endocytic receptor for thrombospondin-1.	LRP2 LRP5	4.31e-06	4	30	2	7775583
Pubmed	Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations.	NLGN4X NLGN4Y	4.31e-06	4	30	2	17292328
Pubmed	Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity.	LRP6 LRP5	4.31e-06	4	30	2	17002572
Pubmed	SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor.	LRP6 LRP5	4.31e-06	4	30	2	15908424
Pubmed	Lrp5 and Lrp6 exert overlapping functions in osteoblasts during postnatal bone acquisition.	LRP6 LRP5	4.31e-06	4	30	2	23675479
Pubmed	Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.	NLGN4X NLGN4Y	4.31e-06	4	30	2	12669065
Pubmed	Shh Plays an Inhibitory Role in Cusp Patterning by Regulation of Sostdc1.	LRP6 LRP5	4.31e-06	4	30	2	30325689
Pubmed	Lrp5/6 are required for cerebellar development and for suppressing TH expression in Purkinje cells via β-catenin.	LRP6 LRP5	4.31e-06	4	30	2	26772978
Pubmed	Homodimerization and isoform-specific heterodimerization of neuroligins.	NLGN4X NLGN4Y	4.31e-06	4	30	2	22671294
Pubmed	Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice.	LRP6 LRP5	4.31e-06	4	30	2	31452509
Pubmed	Caprin-2 enhances canonical Wnt signaling through regulating LRP5/6 phosphorylation.	LRP6 LRP5	4.31e-06	4	30	2	18762581
Pubmed	The Wnt receptor, Lrp5, is expressed by mouse mammary stem cells and is required to maintain the basal lineage.	LRP6 LRP5	7.18e-06	5	30	2	19672307
Pubmed	Role and Regulation of p65/β-Catenin Association During Liver Injury and Regeneration: A "Complex" Relationship.	LRP6 LRP5	7.18e-06	5	30	2	28474571
Pubmed	Analysis of association of LRP5, LRP6, SOST, DKK1, and CTNNB1 genes with bone mineral density in a Slovenian population.	LRP6 LRP5	7.18e-06	5	30	2	19898734
Pubmed	Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells.	LRP6 LRP5	7.18e-06	5	30	2	16805831
Pubmed	Hepatocyte growth factor (Hgf) stimulates low density lipoprotein receptor-related protein (Lrp) 5/6 phosphorylation and promotes canonical Wnt signaling.	LRP6 LRP5	7.18e-06	5	30	2	24692544
Pubmed	Negative regulation of LRP6 function by casein kinase I epsilon phosphorylation.	LRP6 LRP5	7.18e-06	5	30	2	16513652
Pubmed	Wnt/β-catenin signaling modulates corneal epithelium stratification via inhibition of Bmp4 during mouse development.	LRP6 LRP5	7.18e-06	5	30	2	26443636
Pubmed	A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling.	LRP6 LRP5	7.18e-06	5	30	2	12121999
Pubmed	Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling.	LRP6 LRP5	7.18e-06	5	30	2	19107203
Pubmed	Activation/Proliferation-associated Protein 2 (Caprin-2) Positively Regulates CDK14/Cyclin Y-mediated Lipoprotein Receptor-related Protein 5 and 6 (LRP5/6) Constitutive Phosphorylation.	LRP6 LRP5	7.18e-06	5	30	2	27821587
Pubmed	Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.	LRP6 LRP5	7.18e-06	5	30	2	11448771
Pubmed	β-catenin signaling in murine liver zonation and regeneration: a Wnt-Wnt situation!	LRP6 LRP5	7.18e-06	5	30	2	24700412
Pubmed	Neuroligins and neurexins link synaptic function to cognitive disease.	NLGN4X NLGN4Y	7.18e-06	5	30	2	18923512
Pubmed	Synapse formation: if it looks like a duck and quacks like a duck ...	NLGN4X NLGN4Y	7.18e-06	5	30	2	10996085
Pubmed	LDL-receptor-related proteins in Wnt signal transduction.	LRP6 LRP5	7.18e-06	5	30	2	11029007
Pubmed	Multiple N-linked glycosylation sites critically modulate the synaptic abundance of neuroligin isoforms.	NLGN4X NLGN4Y	7.18e-06	5	30	2	37865312
Interaction	GPATCH2 interactions	LRP6 LRP5 BRPF3 BCR	1.97e-07	36	29	4	int:GPATCH2
Interaction	YWHAH interactions	EHBP1 MAST1 TNS2 NKTR HIVEP2 BCR PRAG1 DHX38 SYNGAP1	1.57e-05	1102	29	9	int:YWHAH
Interaction	SOST interactions	LRP2 LRP6 LRP5	1.70e-05	35	29	3	int:SOST
Interaction	DKK2 interactions	LRP2 LRP6 LRP5	4.72e-05	49	29	3	int:DKK2
GeneFamily	Low density lipoprotein receptors	LRP2 LRP6 LRP5	3.29e-07	13	20	3	634
GeneFamily	Fibronectin type III domain containing	IGSF9 EPHA10	1.33e-02	160	20	2	555
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	NRG2 IGSF9	1.35e-02	161	20	2	593
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	BCR PLEKHH3	2.15e-02	206	20	2	682
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	EHBP1 LRP6 NKTR PRAG1	8.08e-06	192	30	4	916fbec1c7ab7969bda711886ac88e877e30c280
Computational	Neighborhood of GSTA4	BRPF3 MAP6 PRRC2B	2.56e-04	68	20	3	GCM_GSTA4
Computational	Neighborhood of RAN	TNS2 BRPF3 MAP6 PRRC2B	4.13e-04	196	20	4	GCM_RAN
Computational	Neighborhood of RBM8A	BRPF3 MAP6 PRRC2B	4.28e-04	81	20	3	GCM_RBM8A
Computational	Neighborhood of BCL2L1	BRPF3 PRRC2B	1.89e-03	35	20	2	GCM_BCL2L1
Computational	Neighborhood of NF2	EHBP1 TNS2 MAP6 PRRC2B	2.07e-03	302	20	4	GCM_NF2
Disease	schizophrenia (implicated_via_orthology)	HIVEP2 MAP6 SYNGAP1	3.68e-05	68	28	3	DOID:5419 (implicated_via_orthology)
Disease	autism spectrum disorder (implicated_via_orthology)	NLGN4X NLGN4Y SYNGAP1	3.99e-04	152	28	3	DOID:0060041 (implicated_via_orthology)
Disease	anorexia nervosa	LRP2 VGLL4	2.02e-03	70	28	2	MONDO_0005351
Disease	hematocrit	LRP2 BRPF3 HIVEP2 ZAN DHX38	2.38e-03	1011	28	5	EFO_0004348

Protein segments in the cluster

Peptide	Gene	Start	Entry
ASRPPYRGRSSESSC	BCR	226	P11274
SRTPTPSDSYCADPR	AJM1	236	C9J069
RSPSPYSLKCSPTRE	BRPF3	16	Q9ULD4
ADREAATSSRPCTPP	INTS8	6	Q75QN2
SCRPRSEYQPSDAPF	MAP6	136	Q96JE9
AEDSCPPSPATERSY	LRP5	1586	O75197
RSDSPPLCPAADSRT	NRG2	806	O14511
SYRHFAPPTTPCSTD	LRP6	1521	O75581
PSRRDPTPTYSATED	LRP2	4626	P98164
SYARSPTDPPSASCT	EPHA10	321	Q5JZY3
PSSRDSSPSRDYSPA	MAST1	946	Q9Y2H9
CPPDYTLTLRRSPDD	NLGN4Y	756	Q8NFZ3
RPRTPSVAYTDCPSR	PAX1	436	P15863
PRAARSYSCSAPEAP	FAM189B	396	P81408
SPASLDTRTCGYPPE	COLCA2	66	A8K830
PDDHLSPSTASPYCR	EHBP1	631	Q8NDI1
SPSTASPYCRRTKSD	EHBP1	636	Q8NDI1
CPPDYTLTLRRSPDD	NLGN4X	756	Q8N0W4
RRDSLSPYSCVSTPS	HSF5	196	Q4G112
YLANPSPERPCSSSS	PLEKHH3	746	Q7Z736
YHTPPRSRSCSESDD	NKTR	341	P30414
GPASYRRPPSAATTC	VGLL4	191	Q14135
DRSGSCSSLSPPRYE	SPEN	761	Q96T58
PPLARSSPAYCTSSS	SYNGAP1	811	Q96PV0
PSDTCGSRRPTDRDY	PRRC2B	1241	Q5JSZ5
ESPSPTPSYRDSERS	DHX38	231	Q92620
APPDYMDTRRCPTSS	IGSF9	951	Q9P2J2
STSPDGNSRCPPAYT	PRAG1	146	Q86YV5
LYSSSRPSRPSTSPC	ZBTB32	466	Q9Y2Y4
LSPVPSSAPSTCRYT	TMEM217	211	Q8N7C4
SSPGYDSSPCRDNSP	HIVEP2	2046	P31629
PRSPRDAPCSASSEL	TNS2	891	Q63HR2
TSRSSTERCPPNARY	ZAN	1036	Q9Y493