Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiondouble-stranded RNA binding

DHX36 LSM14A HNRNPU

1.75e-0478283GO:0003725
GeneOntologyMolecularFunctiontelomerase RNA binding

DHX36 HNRNPU

5.58e-0425282GO:0070034
GeneOntologyBiologicalProcessregulation of cytoplasmic translation

DHX36 HNRNPU CPEB4

1.69e-0537283GO:2000765
HumanPhenoUnilateral cleft lip

GDF11 MED12

3.46e-051052HP:0100333
HumanPhenoPartial anomalous pulmonary venous return

KMT2D MED12

4.22e-051152HP:0010773
HumanPhenoSkin tags

KMT2D MED12 HNRNPU

6.51e-059753HP:0010609
HumanPhenoUnilateral cleft palate

GDF11 MED12

1.45e-042052HP:0100334
HumanPhenoAbnormal periauricular region morphology

KMT2D MED12 HNRNPU

1.60e-0413153HP:0000383
HumanPhenoHydrocephalus

KMT2D MED12 NADK2 HNRNPU

2.15e-0442154HP:0000238
HumanPhenoUnilateral cleft lip/palate

GDF11 MED12

2.29e-042552HP:0100331
HumanPhenoIntestinal malrotation

KMT2D MED12 HNRNPU

2.74e-0415753HP:0002566
HumanPhenoAnal stenosis

KMT2D MED12

4.27e-043452HP:0002025
HumanPhenoNon-midline cleft palate

GDF11 MED12

4.27e-043452HP:0100338
HumanPhenoCleft upper lip

KMT2D GDF11 MED12

4.32e-0418353HP:0000204
HumanPhenoAbnormality of the helix

KMT2D GDF11 MED12

4.32e-0418353HP:0000380
HumanPhenoSmooth philtrum

KMT2D MED12 HNRNPU

4.47e-0418553HP:0000319
HumanPhenoNasolacrimal duct obstruction

KMT2D MED12

4.79e-043652HP:0000579
HumanPhenoAbnormal helix morphology

KMT2D GDF11 MED12

6.68e-0421253HP:0011039
HumanPhenoThird trimester onset

KMT2D NADK2

7.50e-044552HP:0034197
HumanPhenoVesicoureteral reflux

KMT2D MED12 HNRNPU

7.55e-0422153HP:0000076
HumanPhenoProminent fingertip pads

KMT2D MED12

7.84e-044652HP:0001212
HumanPhenoProminent digit pad

KMT2D MED12

8.54e-044852HP:0011298
HumanPhenoAbnormal lacrimal duct morphology

KMT2D MED12

9.27e-045052HP:0011481
HumanPhenoCleft soft palate

KMT2D GDF11 MED12

9.39e-0423853HP:0000185
HumanPhenoEpicanthus

KMT2D GDF11 MED12 HNRNPU

9.46e-0461454HP:0000286
HumanPhenoCleft secondary palate

KMT2D GDF11 MED12

9.63e-0424053HP:0410004
HumanPhenoCleft lip

KMT2D GDF11 MED12

9.63e-0424053HP:0410030
HumanPhenoAbnormal ureter physiology

KMT2D MED12 HNRNPU

1.02e-0324553HP:0025634
HumanPhenoNon-midline cleft of the upper lip

GDF11 MED12

1.04e-035352HP:0100335
HumanPhenoNon-midline cleft lip/palate

GDF11 MED12

1.08e-035452HP:0100332
HumanPhenoDialeptic seizure

KMT2D NADK2 HNRNPU

1.10e-0325153HP:0011146
HumanPhenoAbnormal cerebrospinal fluid morphology

KMT2D MED12 NADK2 HNRNPU

1.15e-0364654HP:0002921
HumanPhenoAbnormal hair pattern

KMT2D GDF11 MED12 HNRNPU

1.38e-0367654HP:0010720
HumanPhenoPreauricular pit

KMT2D MED12

1.38e-036152HP:0004467
HumanPhenoProminent occiput

GDF11 MED12

1.42e-036252HP:0000269
HumanPhenoAbnormal cheek morphology

KMT2D MED12 HNRNPU

1.54e-0328253HP:0004426
HumanPhenoAplasia/Hypoplasia of the optic nerve

KMT2D MED12 NADK2 HNRNPU

1.61e-0370454HP:0008058
HumanPhenoAbnormal midface morphology

KMT2D GDF11 MED12 HNRNPU

1.61e-0370454HP:0000309
HumanPhenoAbnormal soft palate morphology

KMT2D GDF11 MED12

1.66e-0328953HP:0100736
HumanPhenoPeriauricular skin pits

KMT2D MED12

1.66e-036752HP:0100277
HumanPhenoAnteriorly placed anus

KMT2D MED12

1.71e-036852HP:0001545
HumanPhenoAbnormality of the hairline

KMT2D GDF11 MED12

1.74e-0329453HP:0009553
HumanPhenoCupped ear

KMT2D MED12

1.76e-036952HP:0000378
HumanPhenoHigh forehead

KMT2D MED12 HNRNPU

1.96e-0330653HP:0000348
HumanPhenoProlonged neonatal jaundice

KMT2D MED12

2.02e-037452HP:0006579
HumanPhenoNeonatal jaundice

KMT2D MED12

2.02e-037452HP:0000986
HumanPhenoInguinal hernia

KMT2D GDF11 MED12

2.07e-0331253HP:0000023
HumanPhenoHigh anterior hairline

GDF11 MED12

2.13e-037652HP:0009890
HumanPhenoBroad hallux

KMT2D MED12

2.13e-037652HP:0010055
HumanPhenoBranchial anomaly

KMT2D MED12

2.25e-037852HP:0009794
HumanPhenoAplasia/Hypoplasia of the corpus callosum

KMT2D MED12 NADK2 HNRNPU

2.30e-0377254HP:0007370
HumanPhenoCongenital abnormal hair pattern

KMT2D GDF11 MED12

2.38e-0332753HP:0011361
HumanPhenoPeriauricular skin tag

KMT2D HNRNPU

2.42e-038152HP:0100278
HumanPhenoPreauricular skin tag

KMT2D HNRNPU

2.42e-038152HP:0000384
HumanPhenoVentriculomegaly

KMT2D MED12 NADK2 HNRNPU

2.52e-0379054HP:0002119
HumanPhenoAnomalous pulmonary venous return

KMT2D MED12

2.54e-038352HP:0010772
HumanPhenoSkin pit

KMT2D MED12

2.60e-038452HP:0100276
HumanPhenoAbnormal nasolacrimal system morphology

KMT2D MED12

2.79e-038752HP:0000614
HumanPhenoBroad toe

KMT2D MED12

2.79e-038752HP:0001837
HumanPhenoAbnormal pulmonary vein morphology

KMT2D MED12

2.92e-038952HP:0030968
HumanPhenoAbnormality of the pulmonary veins

KMT2D MED12

2.92e-038952HP:0011718
HumanPhenoAbnormally folded helix

KMT2D MED12

2.98e-039052HP:0008544
HumanPhenoEctopic anus

KMT2D MED12

3.18e-039352HP:0004397
HumanPhenoMicrognathia

KMT2D GDF11 MED12 HNRNPU

3.24e-0384354HP:0000347
HumanPhenoAplasia/Hypoplasia of the mandible

KMT2D GDF11 MED12 HNRNPU

3.27e-0384554HP:0009118
HumanPhenoAspiration pneumonia

KMT2D NADK2

3.32e-039552HP:0011951
DomainPWI

RBM27 RBM26

2.49e-055302PF01480
Domain-

RBM27 RBM26

2.49e-0553021.20.1390.10
DomainPWI_dom

RBM27 RBM26

2.49e-055302IPR002483
DomainTCEAL1

TCEAL6 TCEAL3

8.92e-059302IPR010370
DomainBEX

TCEAL6 TCEAL3

2.24e-0414302PF04538
DomainTF_A-like/BEX

TCEAL6 TCEAL3

2.24e-0414302IPR021156
DomainGRAM

TBC1D8 TBC1D9B

2.95e-0416302SM00568
DomainGRAM

TBC1D8 TBC1D9B

5.65e-0422302PF02893
DomainGRAM

TBC1D8 TBC1D9B

5.65e-0422302IPR004182
Domain-

RBM27 RBM26

1.87e-03403024.10.1000.10
Domainzf-CCCH

RBM27 RBM26

2.80e-0349302PF00642
DomainTBC

TBC1D8 TBC1D9B

2.80e-0349302SM00164
DomainRabGAP-TBC

TBC1D8 TBC1D9B

3.27e-0353302PF00566
DomainTBC_RABGAP

TBC1D8 TBC1D9B

3.51e-0355302PS50086
DomainRab-GTPase-TBC_dom

TBC1D8 TBC1D9B

3.51e-0355302IPR000195
DomainZnf_CCCH

RBM27 RBM26

3.90e-0358302IPR000571
DomainZF_C3H1

RBM27 RBM26

3.90e-0358302PS50103
DomainRRM_1

RBM27 CPEB4 RBM26

4.43e-03208303PF00076
DomainRRM

RBM27 CPEB4 RBM26

4.98e-03217303SM00360
DomainRRM_dom

RBM27 CPEB4 RBM26

5.65e-03227303IPR000504
DomainRRM

RBM27 CPEB4 RBM26

5.86e-03230303PS50102
Domain-

RBM27 CPEB4 RBM26

6.89e-032443033.30.70.330
DomainNucleotide-bd_a/b_plait

RBM27 CPEB4 RBM26

8.03e-03258303IPR012677
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

DHX36 LSM14A PNN RBM27 CCDC9 HNRNPU CPEB4 RBM26

3.02e-0780730822681889
Pubmed

A family of RS domain proteins with novel subcellular localization and trafficking.

RBM27 RBM26

7.19e-07230215741184
Pubmed

The human ZC3H3 and RBM26/27 proteins are critical for PAXT-mediated nuclear RNA decay.

RBM27 RBM26

2.16e-06330231950173
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

KMT2D PNN RBM27 MED12 RBM26

3.19e-0626830533640491
Pubmed

Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.

DHX36 ESYT2 RBM27 CCDC9 HNRNPU RBM26

1.73e-0565330633742100
Pubmed

The cell proliferation antigen Ki-67 organises heterochromatin.

DHX36 TMEM214 KMT2D PNN MED12

2.48e-0541030526949251
Pubmed

Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases.

LSM14A HNRNPU

2.58e-05930219858291
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

PRAM1 LSM14A KMT2D RBM27 MED12 HNRNPU RBM26

3.40e-05110330734189442
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

DHX36 LSM14A PNN RBM27 MED12 HNRNPU

4.02e-0575930635915203
Pubmed

Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis.

KMT2D HNRNPU

5.58e-051330221502505
Pubmed

SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.

PRAM1 LSM14A RBM27 HNRNPU

5.70e-0524530435652658
Pubmed

SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.

DHX36 LSM14A PNN CCDC9

6.97e-0525830437794589
Pubmed

mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.

DHX36 PNN RBM27 HNRNPU

8.79e-0527430434244482
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

KMT2D PNN RBM27 MED12 RBM26

9.90e-0554930538280479
Pubmed

Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing.

DHX36 PNN RBM27

1.31e-0411430331553912
Pubmed

cDNAs with long CAG trinucleotide repeats from human brain.

KMT2D MED12

1.80e-04233029225980
Pubmed

Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events.

TCEAL6 TCEAL3

1.96e-042430216221301
Pubmed

PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.

DHX36 RBM27 HNRNPU RBM26

2.01e-0434030424332808
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

DHX36 KMT2D MED12 RBM26

2.03e-0434130432971831
Pubmed

Binding of USP4 to cortactin enhances cell migration in HCT116 human colon cancer cells.

ESYT2 PNN HNRNPU

2.25e-0413730337039823
Pubmed

SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.

DHX36 ESYT2 LSM14A PNN HNRNPU

2.25e-0465530535819319
Pubmed

The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.

ESYT2 LSM14A TMEM214 RBM27 MED12 IFRD2 RBM26

2.30e-04149730731527615
Pubmed

A 1.1-Mb segmental deletion on the X chromosome causes meiotic failure in male mice.

TCEAL6 TCEAL3

2.68e-042830223677977
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

DHX36 PNN RBM27 MED12 HNRNPU CPEB4

2.80e-04108230638697112
Pubmed

HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137.

PNN RBM27 HNRNPU

2.82e-0414830332538781
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

TBC1D8 ESYT2 TMEM214 MED12 HNRNPU

3.22e-0470830539231216
Pubmed

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.

DHX36 PNN RBM27 HNRNPU RBM26

3.33e-0471330529802200
Pubmed

Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.

PNN CCDC9 HNRNPU CPEB4 RBM26

3.55e-0472330534133714
Pubmed

The cellular EJC interactome reveals higher-order mRNP structure and an EJC-SR protein nexus.

PNN CCDC9 HNRNPU

4.16e-0416930323084401
Pubmed

Myristoylated alanine-rich C-kinase substrate effector domain phosphorylation regulates the growth and radiation sensitization of glioblastoma.

CCDC9 HNRNPU

4.20e-043530230942445
Pubmed

Defining human ERAD networks through an integrative mapping strategy.

ESYT2 KMT2D HNRNPU

4.45e-0417330322119785
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

ESYT2 TMEM214 PNN RBM27 MED12 HNRNPU

4.92e-04120330629180619
Pubmed

Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing.

DHX36 HNRNPU

5.50e-044030223825951
Pubmed

Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

DHX36 HNRNPU

6.35e-044330226030138
Pubmed

Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity.

TBC1D8 TBC1D9B

6.35e-044330219077034
Pubmed

Functional dissection of Rab GTPases involved in primary cilium formation.

TBC1D8 TBC1D9B

6.35e-044330217646400
Pubmed

An Interaction Network of the Human SEPT9 Established by Quantitative Mass Spectrometry.

LSM14A RBM27

6.35e-044330230975701
Pubmed

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.

DHX36 MED12 HNRNPU CPEB4

6.41e-0446230431138677
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

ESYT2 TMEM214 KMT2D PNN RBM27 HNRNPU

7.23e-04129430630804502
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

DHX36 LSM14A PNN RBM27 HNRNPU

7.28e-0484730535850772
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

DHX36 ESYT2 PNN RBM27 HNRNPU IFRD2

7.95e-04131830630463901
GeneFamilyTranscription elongation factor A like family

TCEAL6 TCEAL3

4.60e-0592121216
GeneFamilyWD repeat domain containing|GRAM domain containing|BEACH domain containing

TBC1D8 TBC1D9B

9.95e-05132121146
GeneFamilyAtaxins|Trinucleotide repeat containing

KMT2D MED12

3.79e-0425212775
GeneFamilyZinc fingers CCCH-type

RBM27 RBM26

7.47e-043521273
GeneFamilyRNA binding motif containing

RBM27 CPEB4 RBM26

1.83e-03213213725
Diseasenephrotic syndrome type 20 (implicated_via_orthology)

TBC1D8 TBC1D9B

5.20e-064282DOID:0070357 (implicated_via_orthology)
DiseasePhyllodes Tumor

KMT2D MED12

8.67e-065282C0010701
DiseaseMalignant Cystosarcoma Phyllodes

KMT2D MED12

8.67e-065282C0600066
Diseasetotal cholesterol measurement, triglyceride measurement, low density lipoprotein cholesterol measurement, high density lipoprotein cholesterol measurement

TBC1D8 CPEB4

9.93e-0449282EFO_0004530, EFO_0004574, EFO_0004611, EFO_0004612
Diseasereticulocyte count

TBC1D8 LSM14A MED12 CPEB4 IFRD2

2.75e-031045285EFO_0007986
Diseasereticulocyte measurement

TBC1D8 LSM14A MED12 CPEB4 IFRD2

2.84e-031053285EFO_0010700
Diseaseage at menopause

ESYT2 MED12 RBM26

2.88e-03302283EFO_0004704
Diseaselanguage measurement

LSM14A KCNH4

7.16e-03134282EFO_0007797

Protein segments in the cluster

PeptideGeneStartEntry
ARGLRGHRQRGAGAG

ESYT2

66

A0FGR8
RGGIAERGGIRVGHR

APBA3

511

O96018
GAAGRRRAHGQGRSG

CACNG6

16

Q9BXT2
GSLGQGGRGLQGRRT

RNF212B

191

A8MTL3
LSSGRGRGIHSRGRG

RBM26

851

Q5T8P6
SRGRGAVHGRGRGRG

RBM26

861

Q5T8P6
AVHGRGRGRGRGRGV

RBM26

866

Q5T8P6
RGRGGRGRGSLNHMV

RBM27

956

Q9P2N5
KRGRRGGGGLRGING

MBD6

856

Q96DN6
RRARQARRVGGGGGT

GPR162

211

Q16538
RLGGDGGGRRHLGQG

NADK2

36

Q4G0N4
GGGRRHLGQGQPREL

NADK2

41

Q4G0N4
GGGRGRGSLLLRRGF

PNN

51

Q9H307
NRGGGHRGRGGFNMR

HNRNPU

701

Q00839
LHRLTGHFGRRGQGG

KCNH4

176

Q9UQ05
GRGGHRGGRGRFGIR

LSM14A

271

Q8ND56
GGSGGRRQGGRNISV

MED12

1256

Q93074
LGSRLLRGVGGSHGR

REXO2

6

Q9Y3B8
LRGVGGSHGRFGARG

REXO2

11

Q9Y3B8
GGRGRRGRGRGSPHL

CCDC9

126

Q9Y3X0
GRGGRGRHPGHLKGR

DHX36

46

Q9H2U1
RGSRGREGQRGLRGV

COL6A5

1551

A8TX70
GGGGGRRHIRIRSLK

GDF11

211

O95390
GNTLRKGGQRRGGGA

IFRD2

71

Q12894
GSQGRDHRRGLNGGI

CPEB4

311

Q17RY0
LLQGGARQRGLGGRG

VGF

336

O15240
RRGGGKHLGIRRGEI

PRAM1

601

Q96QH2
LQRRRGHGRGGGLTG

TBC1D9B

26

Q66K14
FILQRRRGHGEGGGR

TBC1D8

26

O95759
RRGHGEGGGRLTGRL

TBC1D8

31

O95759
VRGVRGGGRGQRGLH

TCEAL6

181

Q6IPX3
AGGRGGGRNRRALGE

TMEM214

26

Q6NUQ4
VRGVRGGGRGQRGLH

TCEAL3

181

Q969E4
RPGAGGHRGRVAGRL

ZNF764

366

Q96H86
GGAHGGRGRGRARLK

KMT2D

1316

O14686