Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	potassium ion leak channel activity	KCNK10 KCNK6 KCNK4	8.59e-06	16	51	3	GO:0022841
GeneOntologyMolecularFunction	narrow pore channel activity	KCNK10 KCNK6 KCNK4	1.48e-05	19	51	3	GO:0022842
GeneOntologyMolecularFunction	leak channel activity	KCNK10 KCNK6 KCNK4	1.48e-05	19	51	3	GO:0022840
GeneOntologyMolecularFunction	outward rectifier potassium channel activity	KCNK10 KCNK6 KCNK4	4.40e-05	27	51	3	GO:0015271
GeneOntologyBiologicalProcess	stabilization of membrane potential	KCNK10 KCNK6 KCNK4	9.45e-06	17	51	3	GO:0030322
Domain	2pore_dom_K_chnl	KCNK10 KCNK6 KCNK4	7.55e-06	15	49	3	IPR003280
Domain	K_chnl_dom	KCNK10 KCNK6 KCNK4	2.18e-05	21	49	3	IPR013099
Domain	Ion_trans_2	KCNK10 KCNK6 KCNK4	2.18e-05	21	49	3	PF07885
Domain	Pecanex_C	PCNX3 PCNX1	4.03e-05	4	49	2	PF05041
Domain	Pecanex	PCNX3 PCNX1	4.03e-05	4	49	2	IPR007735
Domain	NAP	TSPYL2 TSPYL1	8.94e-04	17	49	2	PF00956
Domain	NAP_family	TSPYL2 TSPYL1	8.94e-04	17	49	2	IPR002164
Domain	FG-GAP	FAM234A ITGA5	1.79e-03	24	49	2	PF01839
Domain	FG-GAP	FAM234A ITGA5	1.79e-03	24	49	2	IPR013517
Domain	WD40_repeat_dom	ARHGEF10 COPB2 DCAF11 ARHGEF10L	7.57e-03	297	49	4	IPR017986
Pathway	REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS	KCNK10 KCNK6 KCNK4	1.90e-06	11	33	3	MM14547
Pathway	REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS	KCNK10 KCNK6 KCNK4	2.53e-06	12	33	3	M1071
Pathway	REACTOME_PHASE_4_RESTING_MEMBRANE_POTENTIAL	KCNK10 KCNK6 KCNK4	1.10e-05	19	33	3	M27452
Pathway	REACTOME_PHASE_4_RESTING_MEMBRANE_POTENTIAL	KCNK10 KCNK6 KCNK4	1.10e-05	19	33	3	MM15194
Pathway	REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE	ARHGEF10 CASP2 ARHGEF10L	5.75e-04	70	33	3	MM14824
Pathway	REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE	ARHGEF10 CASP2 ARHGEF10L	7.31e-04	76	33	3	M19832
Pubmed	Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein.	KCNK10 KCNK6 KCNK4	1.10e-07	7	52	3	18516069
Pubmed	Potassium leak channels and the KCNK family of two-P-domain subunits.	KCNK10 KCNK6 KCNK4	6.87e-07	12	52	3	11256078
Pubmed	International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels.	KCNK10 KCNK6 KCNK4	1.13e-06	14	52	3	16382106
Pubmed	β-COP Suppresses the Surface Expression of the TREK2.	COPB2 KCNK10	2.19e-06	2	52	2	37296621
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TTC28 HTATIP2 TSPYL2 IQSEC1 FMN2 ANKRD17 ZFHX3 TSPYL1 LZTS2 LUZP1	5.16e-06	1116	52	10	31753913
Pubmed	Behavioral characterization of mice lacking Trek channels.	KCNK10 KCNK4	6.57e-06	3	52	2	22973213
Pubmed	Mixing and matching TREK/TRAAK subunits generate heterodimeric K2P channels with unique properties.	KCNK10 KCNK4	6.57e-06	3	52	2	27035965
Pubmed	How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2.	KCNK10 KCNK4	6.57e-06	3	52	2	26332952
Pubmed	Role of the TREK2 potassium channel in cold and warm thermosensation and in pain perception.	KCNK10 KCNK4	6.57e-06	3	52	2	25239074
Pubmed	Lysophosphatidic acid-operated K+ channels.	KCNK10 KCNK4	6.57e-06	3	52	2	15572365
Pubmed	TSPYL1 as a Critical Regulator of TGFβ Signaling through Repression of TGFBR1 and TSPYL2.	TSPYL2 TSPYL1	6.57e-06	3	52	2	38588050
Pubmed	Zinc and mercuric ions distinguish TRESK from the other two-pore-domain K+ channels.	KCNK10 KCNK6	6.57e-06	3	52	2	16354767
Pubmed	Tension activation of mechanosensitive two-pore domain K+ channels TRAAK, TREK-1, and TREK-2.	KCNK10 KCNK4	6.57e-06	3	52	2	38605031
Pubmed	Elevated expression of TREK-TRAAK K2P channels in the retina of adult rd1 mice.	KCNK10 KCNK4	1.31e-05	4	52	2	31236347
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ANKRD17 UNK SMPD4 PCNX1 LZTS2 NACAD ARHGEF10L	1.34e-05	529	52	7	14621295
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	STON1 TTC28 UNK LZTS2 LUZP1	1.54e-05	209	52	5	36779422
Pubmed	Glucose inhibition persists in hypothalamic neurons lacking tandem-pore K+ channels.	KCNK10 KCNK4	2.19e-05	5	52	2	19244527
Pubmed	K(+) efflux through two-pore domain K(+) channels is required for mouse embryonic development.	KCNK10 KCNK4	2.19e-05	5	52	2	22419831
Pubmed	Piezo1 and Piezo2 foster mechanical gating of K2P channels.	KCNK10 KCNK4	2.19e-05	5	52	2	34852225
Pubmed	Mechanoprotection by polycystins against apoptosis is mediated through the opening of stretch-activated K(2P) channels.	KCNK10 KCNK4	2.19e-05	5	52	2	22832196
Pubmed	Insights into the release mechanism of astrocytic glutamate evoking in neurons NMDA receptor-mediated slow depolarizing inward currents.	KCNK10 KCNK4	3.28e-05	6	52	2	30144319
Pubmed	Kv1.1 channels act as mechanical brake in the senses of touch and pain.	KCNK10 KCNK4	4.58e-05	7	52	2	23473320
Pubmed	Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins.	KCNK10 KCNK4	6.10e-05	8	52	2	28839101
Pubmed	A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K(+) Channels.	KCNK10 KCNK4	6.10e-05	8	52	2	26919430
Pubmed	Elongation factor 1 alpha1 and genes associated with Usher syndromes are downstream targets of GBX2.	MYO15A USH2A	7.84e-05	9	52	2	23144817
Pubmed	Trim43a, Trim43b, and Trim43c: Novel mouse genes expressed specifically in mouse preimplantation embryos.	TRIM64B TRIM64	2.27e-04	15	52	2	19703589
Pubmed	Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain.	ARHGEF10 ARHGEF10L	3.30e-04	18	52	2	12799088
Pubmed	Identification of a genomic reservoir for new TRIM genes in primate genomes.	TRIM64B TRIM64	3.69e-04	19	52	2	22144910
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	BIVM UNK SMPD4 DCAF11 HRNR MYO15A NACAD CREB3L1	4.81e-04	1242	52	8	30973865
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	TTC28 UNK TSPYL1 LZTS2 LUZP1	5.37e-04	446	52	5	24255178
Pubmed	Identification of proteins that interact with alpha A-crystallin using a human proteome microarray.	COPB2 DCAF11 ARMCX4	7.45e-04	118	52	3	24453475
Pubmed	An inter-species protein-protein interaction network across vast evolutionary distance.	COPB2 CASP2 ZFHX3 LZTS2 CREB3L1	7.68e-04	483	52	5	27107014
Pubmed	Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.	FAM234A TSPYL2 UBA6 SMPD4 TSPYL1 KCNK4	8.63e-04	750	52	6	11230166
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	COPB2 FMN2 SMPD4 LZTS2 ITGA5 TARS2 LUZP1	9.12e-04	1049	52	7	27880917
Pubmed	Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.	MSRB3 ZFHX3	1.49e-03	38	52	2	33283408
Cytoband	11q14.3	TRIM64B TRIM64	6.11e-04	32	52	2	11q14.3
GeneFamily	Potassium two pore domain channel subfamily K	KCNK10 KCNK6 KCNK4	2.48e-06	15	33	3	277
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF10 ARHGEF10L	6.44e-03	66	33	2	722
Drug	Naloxone hydrochloride [357-08-4]; Down 200; 11uM; PC3; HT_HG-U133A	CASP2 UBA6 PCNX1 ZFHX3 DCAF11 CREB3L1	3.87e-06	196	49	6	4645_DN
Drug	thapsigargin; Down 200; 0.1uM; MCF7; HT_HG-U133A	IQSEC1 ST3GAL2 ITGA5 LUZP1 ARHGEF10L	5.57e-05	191	49	5	7100_DN
Drug	Diltiazem hydrochloride [33286-22-5]; Down 200; 8.8uM; PC3; HT_HG-U133A	CASP2 UBA6 ST3GAL2 DCAF11 CREB3L1	5.57e-05	191	49	5	6710_DN
Drug	Chlorpromazine hydrochloride [69-09-0]; Down 200; 11.2uM; PC3; HT_HG-U133A	CASP2 PCNX1 DCAF11 POLQ ARHGEF10L	5.85e-05	193	49	5	5074_DN
Drug	Methoxy-6-harmalan [3589-73-9]; Down 200; 18.6uM; MCF7; HT_HG-U133A	TTC28 CASP2 PCNX1 ST3GAL2 LUZP1	6.15e-05	195	49	5	5455_DN
Drug	Tremorine dihydrochloride [300-68-5]; Down 200; 15uM; MCF7; HT_HG-U133A	HTATIP2 TSPYL2 UBA6 LRP3 LUZP1	6.30e-05	196	49	5	6273_DN
Drug	Cyclobenzaprine hydrochloride [6202-23-9]; Down 200; 12.8uM; MCF7; HT_HG-U133A	LRP3 PCNX1 ST3GAL2 DCAF11 LUZP1	6.30e-05	196	49	5	4834_DN
Drug	Clorgyline hydrochloride [17780-75-5]; Down 200; 13uM; MCF7; HT_HG-U133A	IQSEC1 CASP2 PCNX1 DCAF11 LUZP1	6.30e-05	196	49	5	5005_DN
Drug	Nicergoline; Down 200; 8.2uM; PC3; HT_HG-U133A	TSPYL2 ANKRD17 PCNX1 ST3GAL2 DCAF11	6.30e-05	196	49	5	2058_DN
Drug	PHA-00851261E [724719-49-7]; Down 200; 1uM; MCF7; HT_HG-U133A	STON1 TSPYL2 PCNX1 ST3GAL2 LUZP1	6.30e-05	196	49	5	3857_DN
Drug	Mometasone furoate [83919-23-7]; Down 200; 7.6uM; HL60; HG-U133A	TSPYL2 CASP2 PCNX1 TSPYL1 ARHGEF10L	6.45e-05	197	49	5	1746_DN
Drug	Levopropoxyphene napsylate [5714-90-9]; Down 200; 7.4uM; MCF7; HT_HG-U133A	TTC28 CASP2 PCNX1 TARS2 ARHGEF10L	6.45e-05	197	49	5	5503_DN
Drug	mefenamic acid	KCNK10 CREB3L1 KCNK4	6.91e-05	37	49	3	CID000004044
Drug	Trimethoprim [738-70-5]; Down 200; 13.8uM; MCF7; HT_HG-U133A	CASP2 LRP3 PCNX1 ZFHX3 LUZP1	6.93e-05	200	49	5	4701_DN
Disease	hearing impairment	MSRB3 MYO15A USH2A	5.18e-04	98	47	3	C1384666
Disease	alpha fetoprotein measurement	ANKRD17 UNK POLQ	5.50e-04	100	47	3	EFO_0010583
Disease	heart conduction disease (implicated_via_orthology)	KCNK10 KCNK4	1.19e-03	32	47	2	DOID:10273 (implicated_via_orthology)
Disease	thyroid carcinoma	STON1 HTATIP2	1.77e-03	39	47	2	EFO_0002892
Disease	spondylosis	IQSEC1 UNC13C	1.86e-03	40	47	2	MONDO_0002253
Disease	ovarian serous carcinoma	STON1 TTC28	2.46e-03	46	47	2	EFO_1001516
Disease	colorectal cancer	FOXO6 ARHGEF10 FMN2 PCNX1 NACAD	2.67e-03	604	47	5	MONDO_0005575
Disease	lung adenocarcinoma (is_implicated_in)	IQSEC1 ZFHX3	2.78e-03	49	47	2	DOID:3910 (is_implicated_in)
Disease	overall survival, pancreatic carcinoma	KCNK10 IQSEC1	2.78e-03	49	47	2	EFO_0000638, EFO_0002618
Disease	cognitive inhibition measurement	MSRB3 USH2A	2.90e-03	50	47	2	EFO_0007969
Disease	Nonsyndromic Hearing Loss and Deafness, Autosomal Recessive	MSRB3 MYO15A	3.01e-03	51	47	2	cv:CN043650
Disease	basal cell carcinoma	STON1 FOXO6 MYO15A	3.41e-03	189	47	3	EFO_0004193

Protein segments in the cluster

Peptide	Gene	Start	Entry
FTGETLWNHSSSFSG	FAM234A	191	Q9H0X4
SQPDSFSTAHGFLWI	ARHGEF10	911	O15013
AADAAFSGARHSSWK	ARHGEF10L	96	Q9HCE6
GNGTSPDFSHSKEWF	CREB3L1	491	Q96BA8
KSFGSAQEFAWAHDS	COPB2	386	P35606
GRSFSASFHQDSAWK	BIVM	466	Q86UB2
TLFENSPTSAHAFWG	ANKRD17	2256	O75179
SGSIWQQSFPASAHK	CREG2	66	Q8IUH2
WSETKFAHQSEASFP	ARMCX4	1996	Q5H9R4
SGSANASDPAWDFAS	KCNK6	81	Q9Y257
SSAADKPLAFSGWAS	LZTS2	196	Q9BRK4
KFFGSLPDSWASGHS	HTATIP2	186	Q9BUP3
ASAFFWGLHTGPQKT	MYO15A	56	Q9UKN7
SNSSHSAWDLGSAFF	KCNK4	81	Q9NYG8
HKEARNSWDSPAFSN	IQSEC1	506	Q6DN90
ITWGSAFHAFAQPFA	PCNX1	1466	Q96RV3
SLTGGWFFDPHQSTF	PCNX3	16	Q9H6A9
FTPDGNHFLYSSWSD	DCAF11	226	Q8TEB1
AAAKWAASPASHASD	FOXO6	226	A8MYZ6
KRQESSFSHSSWSAG	HRNR	121	Q86YZ3
SAASSGPWAHSLFAF	EVC2	116	Q86UK5
WIFFHSDASSSGQAQ	LRP3	136	O75074
SNNSSHWDLGSAFFF	KCNK10	146	P57789
ESPAGHSFLSWLGFS	SMPD4	616	Q9NXE4
LWAASHTPDFFGSAL	ITGA5	446	P08648
TSPHSKFQERQFWSG	GCFC2	636	P16383
NHSFIWSGASFDLSP	POLQ	1626	O75417
WKSHSAPSEVGFSDA	LUZP1	901	Q86V48
SSGSPANSFHFKEAW	EEF2K	71	O00418
VSPNAFFSIWHEFSS	FMN2	1656	Q9NZ56
MAAPSAGSWSTFQHK	CASP2	1	P42575
DTSNKHSWTPARFSG	IGLV7-46	71	A0A075B6I9
HWFSAPLKSSAVSFQ	DIPK1C	356	Q0P6D2
SWVSGFTNSALHSSF	OR2J3	151	O76001
TFDSPEGKAVFWHSS	TARS2	121	Q9BW92
VASNGFGSAHSSWIP	USH2A	2511	O75445
ASDWFDSHFDGNISP	ST3GAL2	81	Q16842
SETKFDSGSGWPSFH	MSRB3	96	Q8IXL7
ESSFSHKPSLFNKFW	UBA6	646	A0AVT1
GNQDASHSFFSWFSN	TSPYL2	356	Q9H2G4
SHSFFSWFSNHSLPE	TSPYL2	361	Q9H2G4
ATPLWHSQSDFFTAK	UNC13C	531	Q8NB66
AFSSPFWKDEGSDSH	STON1	181	Q9Y6Q2
SFFTWFSDHSLPESD	TSPYL1	376	Q9H0U9
FTWWQPHAKDSFSSN	SPATA31D1	356	Q6ZQQ2
SKAFSHPSNWAGFML	TTC28	1696	Q96AY4
AKAEWSVHPNSDFFG	ZXDA	751	P98168
SFAVWGAQAFTSGKH	TRIM64	326	A6NGJ6
IWEHFASGSFSPGTS	UNK	621	Q9C0B0
SFAVWGAQAFTSGKH	TRIM64B	326	A6NI03
NTFHIASSFGKWFEG	ZFHX3	196	Q15911
SADSSSSWGQEGHFF	NACAD	281	O15069
VADIDGSTFWSHPFN	NMD3	291	Q96D46