Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	SUMO ligase activity	PIAS3 CBX4 PIAS1	4.32e-05	20	69	3	GO:0061665
GeneOntologyMolecularFunction	SUMO transferase activity	PIAS3 CBX4 PIAS1	2.60e-04	36	69	3	GO:0019789
GeneOntologyBiologicalProcess	Rap protein signal transduction	RAP2A RAP2B RAP2C	1.38e-05	14	71	3	GO:0032486
GeneOntologyBiologicalProcess	protein sumoylation	PIAS3 CBX4 PIAS1 SENP5	1.05e-04	71	71	4	GO:0016925
GeneOntologyBiologicalProcess	microvillus assembly	RAP2A RAP2B RAP2C	1.20e-04	28	71	3	GO:0030033
GeneOntologyBiologicalProcess	positive regulation of protein autophosphorylation	RAP2A RAP2B RAP2C	1.34e-04	29	71	3	GO:0031954
GeneOntologyBiologicalProcess	protein autophosphorylation	RAP2A RAP2B HIPK4 CDK12 IRAK1 RAP2C	1.34e-04	228	71	6	GO:0046777
GeneOntologyBiologicalProcess	polarized epithelial cell differentiation	DLG5 RAP2A LAMA1	1.48e-04	30	71	3	GO:0030859
Domain	PINIT	PIAS3 PIAS1	7.80e-05	4	68	2	IPR023321
Domain	PINIT	PIAS3 PIAS1	7.80e-05	4	68	2	PS51466
Domain	PINIT	PIAS3 PIAS1	7.80e-05	4	68	2	PF14324
Domain	CBX7_C	CBX4 CBX8	1.30e-04	5	68	2	IPR033773
Domain	CBX7_C	CBX4 CBX8	1.30e-04	5	68	2	PF17218
Domain	zf-MIZ	PIAS3 PIAS1	2.71e-04	7	68	2	PF02891
Domain	ZF_SP_RING	PIAS3 PIAS1	2.71e-04	7	68	2	PS51044
Domain	RAS	RAP2A RAP2B RAP2C	2.78e-04	35	68	3	PS51421
Domain	Small_GTPase_Ras	RAP2A RAP2B RAP2C	3.28e-04	37	68	3	IPR020849
Domain	Znf_MIZ	PIAS3 PIAS1	3.61e-04	8	68	2	IPR004181
Domain	Rib_L2_dom2	CUL9 RPL6	1.92e-03	18	68	2	IPR014722
Domain	Chromodomain_CS	CBX4 CBX8	1.92e-03	18	68	2	IPR023779
Domain	-	CUL9 RPL6	1.92e-03	18	68	2	2.30.30.30
Domain	-	PIAS3 PIAS1	2.62e-03	21	68	2	1.10.720.30
Domain	SAP	PIAS3 PIAS1	2.88e-03	22	68	2	PF02037
Domain	SAP	PIAS3 PIAS1	3.15e-03	23	68	2	SM00513
Domain	Chromo_domain	CBX4 CBX8	3.42e-03	24	68	2	IPR023780
Domain	SAP	PIAS3 PIAS1	3.71e-03	25	68	2	PS50800
Domain	SAP_dom	PIAS3 PIAS1	3.71e-03	25	68	2	IPR003034
Domain	Chromo	CBX4 CBX8	4.01e-03	26	68	2	PF00385
Domain	CHROMO_1	CBX4 CBX8	4.64e-03	28	68	2	PS00598
Domain	CHROMO_2	CBX4 CBX8	4.64e-03	28	68	2	PS50013
Domain	Chromodomain-like	CBX4 CBX8	6.04e-03	32	68	2	IPR016197
Domain	Chromo/shadow_dom	CBX4 CBX8	6.41e-03	33	68	2	IPR000953
Domain	CHROMO	CBX4 CBX8	6.41e-03	33	68	2	SM00298
Domain	Prot_kinase_dom	HIPK4 IKBKE CDK12 TBK1 IRAK1 PAN3	8.69e-03	489	68	6	IPR000719
Domain	PROTEIN_KINASE_DOM	HIPK4 IKBKE CDK12 TBK1 IRAK1 PAN3	9.03e-03	493	68	6	PS50011
Domain	Ser/Thr_kinase_AS	HIPK4 IKBKE CDK12 TBK1 IRAK1	9.67e-03	357	68	5	IPR008271
Domain	S_TKc	HIPK4 IKBKE CDK12 TBK1 IRAK1	9.89e-03	359	68	5	SM00220
Domain	PROTEIN_KINASE_ST	HIPK4 IKBKE CDK12 TBK1 IRAK1	1.02e-02	362	68	5	PS00108
Pathway	REACTOME_SUMOYLATION_OF_TRANSCRIPTION_COFACTORS	PIAS3 CBX4 PIAS1 CBX8	2.26e-05	40	59	4	MM15000
Pathway	REACTOME_SUMOYLATION_OF_TRANSCRIPTION_COFACTORS	PIAS3 CBX4 PIAS1 CBX8	3.32e-05	44	59	4	M27295
Pathway	REACTOME_SUMOYLATION	PIAS3 IKBKE CBX4 PIAS1 CBX8 SENP5	7.23e-05	169	59	6	MM14919
Pathway	REACTOME_SUMOYLATION	PIAS3 IKBKE CBX4 PIAS1 CBX8 SENP5	1.34e-04	189	59	6	M27214
Pathway	WP_TLR4_SIGNALING_AND_TOLERANCE	IKBKE TBK1 IRAK1	2.12e-04	28	59	3	M39561
Pathway	WP_TOLLLIKE_RECEPTOR_SIGNALING_RELATED_TO_MYD88	IKBKE TBK1 IRAK1	2.88e-04	31	59	3	M39573
Pathway	WP_TOLLLIKE_RECEPTOR_SIGNALING	IKBKE TBK1 IRAK1	3.47e-04	33	59	3	MM15940
Pathway	KEGG_MEDICUS_REFERENCE_TLR4_IRF3_7_SIGNALING_PATHWAY	IKBKE TBK1	6.08e-04	9	59	2	M47598
Pathway	KEGG_MEDICUS_REFERENCE_TLR3_IRF3_SIGNALING_PATHWAY	IKBKE TBK1	6.08e-04	9	59	2	M47451
Pathway	WP_SARSCOV2_B117_VARIANT_ANTAGONISES_INNATE_IMMUNE_ACTIVATION	IKBKE TBK1	6.08e-04	9	59	2	M42581
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	DLG5 HIPK4 ARHGEF10 IKBKE CEP162 LPP IQSEC1 SPIRE1 CBX4 CRYBG3 PAN3 DENND4C PPM1H	1.85e-08	861	71	13	36931259
Pubmed	Rap2, but not Rap1 GTPase is expressed in human red blood cells and is involved in vesiculation.	RAP2A RAP2B RAP2C	3.26e-08	4	71	3	16540189
Pubmed	Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system.	IKBKE TBK1 IRAK1	8.13e-08	5	71	3	22007846
Pubmed	SUMO E3 ligases are expressed in the retina and regulate SUMOylation of the metabotropic glutamate receptor 8b.	PIAS3 CBX4 PIAS1	8.13e-08	5	71	3	21288202
Pubmed	Ubiquitylation by Rab40b/Cul5 regulates Rap2 localization and activity during cell migration.	RAP2A RAP2B RAP2C	8.13e-08	5	71	3	35293963
Pubmed	A novel IRAK1-IKKε signaling axis limits the activation of TAK1-IKKβ downstream of TLR3.	IKBKE TBK1 IRAK1	8.13e-08	5	71	3	23396947
Pubmed	Human cystathionine beta-synthase is a target for sumoylation.	PIAS3 CBX4 PIAS1	2.84e-07	7	71	3	17087506
Pubmed	Phosphorylation-dependent interaction of SATB1 and PIAS1 directs SUMO-regulated caspase cleavage of SATB1.	PIAS3 CBX4 PIAS1	4.53e-07	8	71	3	20351170
Pubmed	SUMO conjugation to the matrix attachment region-binding protein, special AT-rich sequence-binding protein-1 (SATB1), targets SATB1 to promyelocytic nuclear bodies where it undergoes caspase cleavage.	PIAS3 CBX4 PIAS1	9.68e-07	10	71	3	18408014
Pubmed	HSP70-Hrd1 axis precludes the oncorepressor potential of N-terminal misfolded Blimp-1s in lymphoma cells.	PIAS3 CBX4 PIAS1	1.33e-06	11	71	3	28842558
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	DLG5 INTS6 RAP2B CDK12 TLN1 SPIRE1 CBX4 UNC93B1 NKAP RAP2C PIAS1 MRPS22 CBX8 CYFIP2	1.70e-06	1497	71	14	31527615
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	DHX16 DLG5 INTS6 ZBTB38 CDK12 IQSEC1 CBX4 PAN3 PLRG1 RPL6 MRPS22 CBX8	1.83e-06	1082	71	12	38697112
Pubmed	The role of TBK1 and IKKε in the expression and activation of Pellino 1.	IKBKE TBK1 IRAK1	2.30e-06	13	71	3	21204785
Pubmed	Rap2A links intestinal cell polarity to brush border formation.	RAP2A RAP2B RAP2C	3.64e-06	15	71	3	22797597
Pubmed	Identification of TBK1 and IKKε, the non-canonical IκB kinases, as crucial pro-survival factors in HTLV-1-transformed T lymphocytes.	IKBKE TBK1	4.11e-06	2	71	2	27123832
Pubmed	Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation.	IKBKE TBK1	4.11e-06	2	71	2	22619329
Pubmed	Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated.	RAP2A RAP2B	4.11e-06	2	71	2	8424780
Pubmed	IKKε and TBK1 expression in gastric cancer.	IKBKE TBK1	4.11e-06	2	71	2	27145266
Pubmed	Down-regulation of RAB6KIFL/KIF20A, a kinesin involved with membrane trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cell.	KIF20A DLG5	4.11e-06	2	71	2	15665285
Pubmed	Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells.	IKBKE TBK1	4.11e-06	2	71	2	30349097
Pubmed	The kinases IKBKE and TBK1 regulate MYC-dependent survival pathways through YB-1 in AML and are targets for therapy.	IKBKE TBK1	4.11e-06	2	71	2	30504235
Pubmed	Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity.	IKBKE TBK1	4.11e-06	2	71	2	15367631
Pubmed	Identification and biochemical characterization of Rap2C, a new member of the Rap family of small GTP-binding proteins.	RAP2B RAP2C	4.11e-06	2	71	2	16213650
Pubmed	Functionally distinct effects of the C-terminal regions of IKKε and TBK1 on type I IFN production.	IKBKE TBK1	4.11e-06	2	71	2	24722368
Pubmed	IKKε and TBK1 in diffuse large B-cell lymphoma: A possible mechanism of action of an IKKε/TBK1 inhibitor to repress NF-κB and IL-10 signalling.	IKBKE TBK1	4.11e-06	2	71	2	32858764
Pubmed	Super-resolution study of PIAS SUMO E3-ligases in hippocampal and cortical neurons.	PIAS3 PIAS1	4.11e-06	2	71	2	34459572
Pubmed	Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKε and Reveal Mechanisms for Selective Inhibition.	IKBKE TBK1	4.11e-06	2	71	2	30082428
Pubmed	Nuclear accumulation of cRel following C-terminal phosphorylation by TBK1/IKK epsilon.	IKBKE TBK1	4.11e-06	2	71	2	16888014
Pubmed	Identification and analysis of a third mouse Polycomb gene, MPc3.	CBX4 CBX8	4.11e-06	2	71	2	10721694
Pubmed	CDK12 loss inhibits cell proliferation by regulating TBK1 in non-small cell lung cancer cells.	CDK12 TBK1	4.11e-06	2	71	2	37517598
Pubmed	Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated?	IKBKE TBK1	4.11e-06	2	71	2	18353649
Pubmed	Increased IKKϵ protein stability ensures efficient type I interferon responses in conditions of TBK1 deficiency.	IKBKE TBK1	4.11e-06	2	71	2	36936901
Pubmed	Hepatitis C virus NS2 protease inhibits host cell antiviral response by inhibiting IKKε and TBK1 functions.	IKBKE TBK1	4.11e-06	2	71	2	23096996
Pubmed	The non-canonical IκB kinases IKKε and TBK1 as potential targets for the development of novel therapeutic drugs.	IKBKE TBK1	4.11e-06	2	71	2	23157677
Pubmed	The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection.	IKBKE TBK1	4.11e-06	2	71	2	15210742
Pubmed	Crystal structure and mechanism of activation of TANK-binding kinase 1.	IKBKE TBK1	4.11e-06	2	71	2	23453971
Pubmed	Cutting edge: Role of TANK-binding kinase 1 and inducible IkappaB kinase in IFN responses against viruses in innate immune cells.	IKBKE TBK1	4.11e-06	2	71	2	17056502
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	KIF20A DLG5 CEP162 TLN1 TBK1 FAM169A CBX4 DENND4C CBX8	6.57e-06	645	71	9	25281560
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	DHX16 LIG4 CDK12 TBK1 COLGALT2 CRYBG3 PIAS1 PLRG1 RPL6	6.99e-06	650	71	9	38777146
Pubmed	Rap2 function requires palmitoylation and recycling endosome localization.	RAP2A RAP2B RAP2C	1.06e-05	21	71	3	19061864
Pubmed	Viral suppression of innate immunity via spatial isolation of TBK1/IKKε from mitochondrial antiviral platform.	IKBKE TBK1	1.23e-05	3	71	2	24706939
Pubmed	HTLV-1 Tax protein recruitment into IKKε and TBK1 kinase complexes enhances IFN-I expression.	IKBKE TBK1	1.23e-05	3	71	2	25531185
Pubmed	Low-dose endotoxin induces inflammation by selectively removing nuclear receptors and activating CCAAT/enhancer-binding protein δ.	IKBKE IRAK1	1.23e-05	3	71	2	21357541
Pubmed	Modulation of the interferon antiviral response by the TBK1/IKKi adaptor protein TANK.	IKBKE TBK1	1.23e-05	3	71	2	17327220
Pubmed	PIAS genes as disease markers in bipolar disorder.	PIAS3 PIAS1	1.23e-05	3	71	2	30861611
Pubmed	TBK1 and IKKε act like an OFF switch to limit NLRP3 inflammasome pathway activation.	IKBKE TBK1	1.23e-05	3	71	2	34518217
Pubmed	Importance of Validating Antibodies and Small Compound Inhibitors Using Genetic Knockout Studies-T Cell Receptor-Induced CYLD Phosphorylation by IKKε/TBK1 as a Case Study.	IKBKE TBK1	1.23e-05	3	71	2	29755980
Pubmed	Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region.	RAP2A RAP2B	1.23e-05	3	71	2	3045729
Pubmed	SOCS3 Drives Proteasomal Degradation of TBK1 and Negatively Regulates Antiviral Innate Immunity.	IKBKE TBK1	1.23e-05	3	71	2	25939384
Pubmed	Promoter organization of the interferon-A genes differentially affects virus-induced expression and responsiveness to TBK1 and IKKepsilon.	IKBKE TBK1	1.23e-05	3	71	2	16380379
Pubmed	Cloning and analysis of a murine PIAS family member, PIASgamma, in developing skin and neurons.	PIAS3 PIAS1	1.23e-05	3	71	2	10854042
Pubmed	Phosphorylation of RAB7 by TBK1/IKKε Regulates Innate Immune Signaling in Triple-Negative Breast Cancer.	IKBKE TBK1	1.23e-05	3	71	2	31662325
Pubmed	Evasion of antiviral immunity through sequestering of TBK1/IKKε/IRF3 into viral inclusion bodies.	IKBKE TBK1	1.23e-05	3	71	2	24335286
Pubmed	Peroxiredoxin 1 Interacts with TBK1/IKKε and Negatively Regulates Pseudorabies Virus Propagation by Promoting Innate Immunity.	IKBKE TBK1	1.23e-05	3	71	2	34260286
Pubmed	ORF45 of Kaposi's sarcoma-associated herpesvirus inhibits phosphorylation of interferon regulatory factor 7 by IKKε and TBK1 as an alternative substrate.	IKBKE TBK1	1.23e-05	3	71	2	22787218
Pubmed	IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2.	IKBKE TBK1	1.23e-05	3	71	2	11839743
Pubmed	PIAS proteins modulate transcription factors by functioning as SUMO-1 ligases.	PIAS3 PIAS1	1.23e-05	3	71	2	12077349
Pubmed	PRC1 components exhibit different binding kinetics in Polycomb bodies.	CBX4 CBX8	1.23e-05	3	71	2	24460908
Pubmed	The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice.	IKBKE TBK1	1.23e-05	3	71	2	32220666
Pubmed	A20 is a negative regulator of IFN regulatory factor 3 signaling.	IKBKE TBK1	1.23e-05	3	71	2	15661910
Pubmed	Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1.	IKBKE TBK1	1.23e-05	3	71	2	24368730
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	CDK12 GEMIN8 MRPL30 NKAP PLRG1 RPL6 MRPS22 RPL9 CYFIP2	1.46e-05	713	71	9	29802200
Pubmed	MxA interacts with and is modified by the SUMOylation machinery.	CBX4 PIAS1 PLRG1	2.30e-05	27	71	3	25447205
Pubmed	IKKε and TBK1 prevent RIPK1 dependent and independent inflammation.	IKBKE TBK1	2.46e-05	4	71	2	38167258
Pubmed	Estrogen receptor alpha inhibits RLR-mediated immune response via ubiquitinating TRAF3.	IKBKE TBK1	2.46e-05	4	71	2	26186972
Pubmed	Mitochondria-associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS.	IKBKE TBK1	2.46e-05	4	71	2	37967220
Pubmed	Genetically programmed alternative splicing of NEMO mediates an autoinflammatory disease phenotype.	IKBKE TBK1	2.46e-05	4	71	2	35289316
Pubmed	Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2.	RAP2A RAP2B	2.46e-05	4	71	2	10085114
Pubmed	TTLL12 Inhibits the Activation of Cellular Antiviral Signaling through Interaction with VISA/MAVS.	IKBKE TBK1	2.46e-05	4	71	2	28011935
Pubmed	TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells.	IKBKE TBK1	2.46e-05	4	71	2	32268090
Pubmed	SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.	IKBKE TBK1	2.46e-05	4	71	2	16281057
Pubmed	A CRM1-dependent nuclear export pathway is involved in the regulation of IRF-5 subcellular localization.	IKBKE TBK1	2.46e-05	4	71	2	15556946
Pubmed	Sumoylation of the estrogen receptor alpha hinge region regulates its transcriptional activity.	PIAS3 PIAS1	2.46e-05	4	71	2	15961505
Pubmed	Suppression of innate antiviral response by severe acute respiratory syndrome coronavirus M protein is mediated through the first transmembrane domain.	IKBKE TBK1	2.46e-05	4	71	2	24509444
Pubmed	The E3 Ubiquitin Ligase TBK1 Mediates the Degradation of Multiple Picornavirus VP3 Proteins by Phosphorylation and Ubiquitination.	IKBKE TBK1	2.46e-05	4	71	2	31534043
Pubmed	TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation.	IKBKE TBK1	2.46e-05	4	71	2	24562310
Pubmed	Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD.	IKBKE TBK1	2.46e-05	4	71	2	18467330
Pubmed	PIAS proteins promote SUMO-1 conjugation to STAT1.	PIAS3 PIAS1	2.46e-05	4	71	2	12855578
Pubmed	Association of a Network of Interferon-Stimulated Genes with a Locus Encoding a Negative Regulator of Non-conventional IKK Kinases and IFNB1.	IKBKE TBK1	2.46e-05	4	71	2	27705791
Pubmed	Ebola virus protein VP35 impairs the function of interferon regulatory factor-activating kinases IKKepsilon and TBK-1.	IKBKE TBK1	2.46e-05	4	71	2	19153231
Pubmed	Functional dissection of the TBK1 molecular network.	IKBKE TBK1	2.46e-05	4	71	2	21931631
Pubmed	Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon.	RAP2A RAP2B	2.46e-05	4	71	2	12444546
Pubmed	SUMOylation of the corepressor N-CoR modulates its capacity to repress transcription.	PIAS3 PIAS1	2.46e-05	4	71	2	16421255
Pubmed	SUMOylation modulates the transcription repressor function of RIP140.	PIAS3 PIAS1	2.46e-05	4	71	2	18211901
Pubmed	Cellular substrates and pro-apoptotic function of the human HtrA4 protease.	CDK12 CBX4 PIAS1 PLRG1 MRPS22	2.87e-05	173	71	5	31470122
Pubmed	PIAS proteins are involved in the SUMO-1 modification, intracellular translocation and transcriptional repressive activity of RET finger protein.	PIAS3 PIAS1	4.09e-05	5	71	2	15907835
Pubmed	TRAF6-dependent Act1 phosphorylation by the IκB kinase-related kinases suppresses interleukin-17-induced NF-κB activation.	IKBKE TBK1	4.09e-05	5	71	2	22851696
Pubmed	Involvement of the IkappaB kinase (IKK)-related kinases tank-binding kinase 1/IKKi and cullin-based ubiquitin ligases in IFN regulatory factor-3 degradation.	IKBKE TBK1	4.09e-05	5	71	2	17015689
Pubmed	Pellino-1 Positively Regulates Toll-like Receptor (TLR) 2 and TLR4 Signaling and Is Suppressed upon Induction of Endotoxin Tolerance.	TBK1 IRAK1	4.09e-05	5	71	2	26082489
Pubmed	The NEMO adaptor bridges the nuclear factor-kappaB and interferon regulatory factor signaling pathways.	IKBKE TBK1	4.09e-05	5	71	2	17468758
Pubmed	The SARS-CoV-2 papain-like protease suppresses type I interferon responses by deubiquitinating STING.	IKBKE TBK1	4.09e-05	5	71	2	37130168
Pubmed	SUMO-triggered ubiquitination of NR4A1 controls macrophage cell death.	PIAS3 PIAS1	4.09e-05	5	71	2	28622293
Pubmed	IκB kinase ε-dependent phosphorylation and degradation of X-linked inhibitor of apoptosis sensitizes cells to virus-induced apoptosis.	IKBKE TBK1	4.09e-05	5	71	2	22072751
Pubmed	NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway.	IKBKE TBK1	4.09e-05	5	71	2	20389019
Pubmed	The Ret finger protein inhibits signaling mediated by the noncanonical and canonical IkappaB kinase family members.	IKBKE TBK1	4.09e-05	5	71	2	16393995
Pubmed	IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation.	IKBKE TBK1	4.09e-05	5	71	2	21464307
Pubmed	A role for APPL1 in TLR3/4-dependent TBK1 and IKKε activation in macrophages.	IKBKE TBK1	4.09e-05	5	71	2	25780039
Pubmed	Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway.	IKBKE TBK1	4.09e-05	5	71	2	16914100
Pubmed	Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation.	IKBKE TBK1	4.09e-05	5	71	2	25606824
Pubmed	Selective autophagy controls the stability of TBK1 via NEDD4 to balance host defense.	IKBKE TBK1	4.09e-05	5	71	2	34257412
GeneFamily	RAS type GTPase family	RAP2A RAP2B RAP2C	8.99e-05	31	51	3	389
GeneFamily	Zinc fingers MIZ-type	PIAS3 PIAS1	1.62e-04	7	51	2	85
GeneFamily	Chromobox family	CBX4 CBX8	2.16e-04	8	51	2	976
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC35B3 LAMA1 FAM169A RP1 PPM1H	3.21e-06	142	71	5	6469cf82552b39f63e20b841c9eed50de6f58d54
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC-Late_airway_SMC\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	PRUNE2 P2RX1 LPP SPDYE3 PDZD7	6.30e-06	163	71	5	1e8730d75cccf7292010683ab4e81a69d8e3bfa9
ToppCell	facs-Brain_Myeloid-Cerebellum-3m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DCAF6 IQSEC1 SPIRE1 PAN3 PLEK	8.41e-06	173	71	5	869da6a65d1b9b7529c666ec44e3c8ddec2ea408
ToppCell	facs-Brain_Myeloid-Cerebellum-3m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DCAF6 IQSEC1 SPIRE1 PAN3 PLEK	8.41e-06	173	71	5	0672bd8a4a9d18af343d01f09253fb3388896c10
ToppCell	facs-Brain_Myeloid-Cerebellum-3m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DCAF6 IQSEC1 SPIRE1 PAN3 PLEK	8.41e-06	173	71	5	870e091ec30be01a900e1cb8b9ef1880e3b7b50d
ToppCell	343B-Myeloid-Dendritic-pDC\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	P2RX1 IQSEC1 RPL6 CBX8 RPL9	8.89e-06	175	71	5	b30589ff9dc18e745afe61f289e6d576c9c6c6b2
ToppCell	facs-Brain_Myeloid-Cerebellum-3m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DCAF6 IQSEC1 SPIRE1 PAN3 PLEK	8.89e-06	175	71	5	1ea6cf9da26601646f57fa14d558a5e9e1f0b345
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_C\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ITPKC CEP162 SPIRE1 PDZD7 UNC93B1	9.66e-06	178	71	5	50bb1f2c6a8d050ff2af217fd76c3b1b7b4a4a69
ToppCell	human_hepatoblastoma-Tumor_cells-T6\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	PRUNE2 KCNJ5 PLCB4 COLGALT2 CRYBG3	9.92e-06	179	71	5	14fc8ccb6b215063d747643f47d780d2b237eb67
ToppCell	droplet-Lung-30m-Hematologic-myeloid-intermediate_monocyte-intermediate_monocyte_l14\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TLN1 PLEK RPL6 RPL9 CYFIP2	1.02e-05	180	71	5	05cce7e3c13dd3e3b70aaad841097be51cfadad3
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 LAMA1 FAM169A PLCB4 PPM1H	1.05e-05	181	71	5	9d782ba5cf5a172cb4f447763fc50e5b13ef7dd9
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 LAMA1 FAM169A PLCB4 PPM1H	1.08e-05	182	71	5	eb138aa1dca9373f1586600f258df06dcf56d81f
ToppCell	Mild/Remission-B_intermediate-10\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	PTP4A2 ARHGEF10 TLN1 IQSEC1 PLEK	1.10e-05	183	71	5	278064c9f0582463b83bf156d34e77f60187613b
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 LAMA1 PLCB4 RP1 PPM1H	1.23e-05	187	71	5	c41a2c81dd2ceef303f39f699032aa7d6ea67cf0
ToppCell	control-Lymphocytic-CD8_T_cells\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	PTP4A2 ZBTB38 RAP2A RAP2B PLEK	1.50e-05	195	71	5	55b9052336cab3e769a126ecaeef267d8e7bcaa8
ToppCell	severe-Lymphocytic-CD8_T_cells\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	PTP4A2 ZBTB38 RAP2A RAP2B PLEK	1.54e-05	196	71	5	d83acd9abd7b296989b8ae09da63799e6877a149
ToppCell	T_cells-CTLs\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	PTP4A2 ZBTB38 RAP2A PLEK CYFIP2	1.58e-05	197	71	5	28117cf300e169182571fbad0de1681a484a435a
ToppCell	COVID_vent-Lymphocytic-T_cell-CD8+_Memory_T_cell\|COVID_vent / Disease condition, Lineage, Cell class and subclass	PTP4A2 ZBTB38 RAP2A PLEK CYFIP2	1.58e-05	197	71	5	d4dfb3b561d0783cdbee4e8d27009ad81df695cb
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	POGLUT1 RAP2A PCDHB11 COLGALT2	8.06e-05	143	71	4	8f897278f9ccc82ae35e4f30c5f930b2a3eb509d
ToppCell	Tuft-tuft-1\|World / Class top	DCAF6 P2RX1 KCNJ5 SLC5A1	1.50e-04	168	71	4	8ddc2ec483ed2c6c0fb2ae521c6861ceb6d32e34
ToppCell	droplet-Lung-18m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TLN1 PLEK PPM1H CYFIP2	1.50e-04	168	71	4	4b5be7c6662eceddf90a65015f12908278d1664e
ToppCell	droplet-Lung-18m-Hematologic-myeloid-non-classical_monocyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TLN1 PLEK PPM1H CYFIP2	1.50e-04	168	71	4	689c41f6e9f65381570991cc311cba49a57ec955
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Lgr5+_amplifying_undifferentiated_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAP2A GEMIN8 CAPN6 CRYBG3	1.50e-04	168	71	4	d69452e2cfeb74023b5cf3d09064d7dcad0008ec
ToppCell	droplet-Lung-nan-18m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TLN1 PLEK PPM1H CYFIP2	1.53e-04	169	71	4	ba023ee7bb165c2bfbefc2d969ff32ca1eeed33b
ToppCell	droplet-Lung-nan-18m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TLN1 PLEK PPM1H CYFIP2	1.53e-04	169	71	4	c96e0f3241d13926dbee9f91c0c8c5bfa7479a0d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 SLC35B3 FAM169A PPM1H	1.57e-04	170	71	4	5d5f208682be21ed58320f5fc083a7898f8712da
ToppCell	PND03-Immune-Immune_Myeloid-Megakaryocyte/Platelet\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RAP2B P2RX1 KCNJ5 PLEK	1.64e-04	172	71	4	e39ea2f4edbf36ebf9604fa6f9349081859c596c
ToppCell	PND03-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RAP2B P2RX1 KCNJ5 PLEK	1.64e-04	172	71	4	875ea290840e835952623b905eb610f3c71456d2
ToppCell	10x3'2.3-week_14-16-Hematopoietic-HSC/MPP_and_pro-eo/baso/mast_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	PRDM8 RPL6 PPM1H RPL9	1.64e-04	172	71	4	7fb43b3938b9a3b6935ec22d9d853e7d47b82b3c
ToppCell	PND03-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	RAP2B P2RX1 KCNJ5 PLEK	1.64e-04	172	71	4	bcc50bed47465daa953ba91f17d1ee4c947ab461
ToppCell	droplet-Pancreas-Exocrine-21m-Epithelial-pancreatic_ductal_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIPK4 LAMA1 GRIK3 RP1	1.72e-04	174	71	4	a0ccda8fd6f55251cdeff24cf66e72e4a31d2104
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_VWA2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	IKBKE GRIK3 PLCB4 CRYBG3	1.72e-04	174	71	4	43c0e758fa8683708475aec846929ac70d41d7f5
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	KIF20A PRUNE2 ITPKC CYB5R4	1.83e-04	177	71	4	1d5a071157c755f3a27a5c3143015da04ee0b0dc
ToppCell	wk_15-18-Mesenchymal-Chondrocyte-Resting_chondrocyte\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CAPN6 LAMA1 PLCB4 CC2D2B	1.83e-04	177	71	4	b01d7a6a78169962123ddfb0bb588f51d138ad02
ToppCell	droplet-Lung-LUNG-30m-Myeloid-intermediate_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TLN1 PLEK RPL6 RPL9	1.87e-04	178	71	4	3c1246dccdebd6f504ffdfd6eba3a676db9d2e8a
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Intermediate_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TLN1 PLEK RPL6 RPL9	1.87e-04	178	71	4	25a4545dbef4246cf6d27b9b5dde24881da6887e
ToppCell	droplet-Thymus-nan-24m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC93B1 PLEK RPL6 RPL9	1.87e-04	178	71	4	9c6cb39647d5a040ae325bc75148dfddbff7621e
ToppCell	droplet-Lung-30m-Hematologic-myeloid-intermediate_monocyte\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLEK RPL6 RPL9 CYFIP2	1.87e-04	178	71	4	a1f2c134bb7596f678fb4cc11405c374d926ea0f
ToppCell	E18.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	P2RX1 KCNJ5 SLC35B3 PLEK	1.95e-04	180	71	4	ca2a35bfb67347e47f511589a3d0f763e6664634
ToppCell	E18.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet-Megakaryocyte/Platelet_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	P2RX1 KCNJ5 SLC35B3 PLEK	1.95e-04	180	71	4	4e9e8cde2919610c4ac0025b1c9819808048bc1d
ToppCell	E18.5-Immune-Immune_Myeloid-Megakaryocyte/Platelet-Megakaryocyte/Platelet\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	P2RX1 KCNJ5 SLC35B3 PLEK	1.95e-04	180	71	4	466381bf93c3da6a2a241daadb68e9aad2964eae
ToppCell	pdx-Tumor_cells-T6\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	KCNJ5 PLCB4 COLGALT2 CRYBG3	2.04e-04	182	71	4	7b24a4f712e1ae1525e8f1c8ec4e1fc43489cbee
ToppCell	COVID-19_Mild-gd_T\|COVID-19_Mild / Disease condition and Cell class	PTP4A2 TLN1 PLEK CYFIP2	2.08e-04	183	71	4	f593a89b0aa8fffdfa403769916facfd30358521
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_hypoxia/MES-A\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RAP2B IRAK1 RPL9 CC2D2B	2.12e-04	184	71	4	a902109b04a94770f5f6db5ddc372049f2921d38
ToppCell	droplet-Thymus-nan-24m-Myeloid-B_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	UNC93B1 PLEK RPL6 RPL9	2.17e-04	185	71	4	d7fed17356f8bf5900fd106f25b4f7501ad7b590
ToppCell	facs-Thymus-Flowthrough-3m-Lymphocytic-DN_to_DP_transition_(most_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIG4 P2RX1 PAN3 PPM1H	2.17e-04	185	71	4	dc59b8dc459a3c444c9634a0d438cbef54c40036
ToppCell	PCW_05-06-Neuronal-Neuronal_SCP-neuro_proliferating_SCP1_(1)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ATP10B GRIK3 PLCB4 CYFIP2	2.17e-04	185	71	4	a8946379fc066903fe8f4bc9cbf693b7b424a0cd
ToppCell	droplet-Kidney-nan-21m-Epithelial-kidney_loop_of_Henle_ascending_limb_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAM169A COLGALT2 CYFIP2 SLC5A1	2.21e-04	186	71	4	8eafd4bea692f7ef33de27dd53f9d1fe67deaad8
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 LAMA1 RP1 PPM1H	2.21e-04	186	71	4	f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 LAMA1 RP1 PPM1H	2.26e-04	187	71	4	c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCell	368C-Lymphocytic-NK_cells-NK_cell_D3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CBX4 PLRG1 PRXL2C CBX8	2.26e-04	187	71	4	c667fae6440dc98072b584f203d00f0fb1cb2f21
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 LAMA1 RP1 PPM1H	2.31e-04	188	71	4	af740fa78542438fdff627ea1f74f4eee43316be
ToppCell	facs-Thymus-Flowthrough-3m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIG4 P2RX1 PAN3 PPM1H	2.31e-04	188	71	4	59b71462338a7efbacf46577cb07e9db3363afee
ToppCell	Control-B_intermediate-6\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	PTP4A2 TLN1 IQSEC1 PLEK	2.35e-04	189	71	4	11cb9a16f1de8f60af2073ed7ea6d4f41c02f299
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 LAMA1 PLCB4 RP1	2.40e-04	190	71	4	1cf023e3c6924d6a06f353d4b62444b6f2fee8a7
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA1 RP1 RAP2C CYFIP2	2.40e-04	190	71	4	b94df372bc08de11585b2467dba8c8fffff5cd92
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PRUNE2 LAMA1 PLCB4 RP1	2.40e-04	190	71	4	59bbbd2c8d4b7ce46c54ca8022b1557e7e5eee2a
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA1 RP1 RAP2C CYFIP2	2.40e-04	190	71	4	3dcadabbefe0128a5f30ab51234f049ab4d870c6
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTP4A2 RAP2A LPP CYB5R4	2.45e-04	191	71	4	09db184cb90fe282a14474d7217068c58092c6f8
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	KIF20A LAMA1 PPM1H CYFIP2	2.50e-04	192	71	4	25378b5e4b0cea8415ff125783511fc25a56fc00
ToppCell	facs-Skin-nan-18m-Epithelial\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DCAF6 RAP2B HIPK4 PAN3	2.50e-04	192	71	4	bae8df60440875fa04ff01e6c45214854dce0bc7
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA1 RP1 RAP2C CYFIP2	2.50e-04	192	71	4	562df5e87038c500dd3a003fe5374cb31946b145
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KCNJ5 LAMA1 RP1 CYFIP2	2.50e-04	192	71	4	ee27d27e3d269764dbe8711d0b37ff9331a298a9
ToppCell	facs-Skin-nan-18m\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DCAF6 RAP2B HIPK4 PAN3	2.50e-04	192	71	4	3824d5b952be142ac5d13da1ef73813caf640f78
ToppCell	facs-Thymus-nan-3m-Lymphocytic-DN_to_DP_transition_(most_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIG4 P2RX1 PAN3 PPM1H	2.55e-04	193	71	4	a6a864644e1b80b7417ea0a27281e79068a3fd3d
ToppCell	10x3'2.3-week_12-13-Hematopoietic-MK-MK\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	P2RX1 TLN1 PLCB4 PLEK	2.55e-04	193	71	4	3d4411b3c1cb160dec5db29f0c126d8827dfe185
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-stromal_related-FDC\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRUNE2 ARHGEF10 CAPN6 PLCB4	2.60e-04	194	71	4	f9fbb043411546d8c9e0321a64165d411f44aeb7
ToppCell	10x5'v1-week_12-13-Hematopoietic-MK\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	P2RX1 TLN1 PLCB4 PLEK	2.60e-04	194	71	4	245a3eb6db9c862b73ad34a8cd2898a3688c16f6
ToppCell	normal_Lymph_Node-T/NK_cells-Naive_CD8+_T\|normal_Lymph_Node / Location, Cell class and cell subclass	PTP4A2 ZBTB38 COLGALT2 PLEK	2.60e-04	194	71	4	81b8f60d3b81e494051721ce9b8b6aefd415442c
ToppCell	Monocytes-Inflammatory_CD16+_macrophages\|Monocytes / Immune cells in Kidney/Urine in Lupus Nephritis	PTP4A2 P2RX1 RAP2C CYFIP2	2.60e-04	194	71	4	28d19105123b015f8aa25ea8e6c078f630d4ba80
ToppCell	normal_Lymph_Node-T/NK_cells-Naive_CD8+_T\|T/NK_cells / Location, Cell class and cell subclass	PTP4A2 ZBTB38 COLGALT2 PLEK	2.60e-04	194	71	4	72749ab1dd36a0d58624328961e1db08ccba2686
ToppCell	CV-Moderate-0\|CV / Virus stimulation, Condition and Cluster	ZBTB38 PLEK RPL6 RPL9	2.60e-04	194	71	4	9ff69139dae007fcc349daefcb5021defb0e0d2a
ToppCell	HSPCs-Mk_prog.\|World / Lineage and Cell class	P2RX1 KCNJ5 TLN1 PLEK	2.60e-04	194	71	4	5049f4f102844d766eca577e809cf21f7908a9d2
ToppCell	Control-CD8+_Tem\|Control / Disease condition and Cell class	PTP4A2 ZBTB38 RAP2A PLEK	2.65e-04	195	71	4	7503b3e032f95b350a2782d28e4d412a8dc9ebcc
ToppCell	COVID-19_Severe-CD8+_Tem\|COVID-19_Severe / Disease condition and Cell class	ZBTB38 RAP2A TLN1 PLEK	2.65e-04	195	71	4	ff7ae62393e1c858a10592db8e6d9f36b8bae396
ToppCell	10x5'v1-week_12-13-Hematopoietic-MK-early_MK\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	P2RX1 TLN1 PLCB4 PLEK	2.65e-04	195	71	4	fa5fc6f605deb5cae96eec14ba4000b19f877ba6
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_submucosal-gland-SMG_Duct\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	B4GALT2 ATP10B MAEL SLC5A1	2.65e-04	195	71	4	fdbb4abc0c79a6aeace71bfa5a5c5576ca39d758
ToppCell	COVID-19-Lymphoid-pDC\|Lymphoid / Condition, Lineage and Cell class	P2RX1 PLCB4 UNC93B1 PLEK	2.65e-04	195	71	4	4a7c080230ce6a79335ecbeadecb0177b2c13625
ToppCell	Macrophages-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	RAP2B KCNJ5 TLN1 PLEK	2.65e-04	195	71	4	eb104f3bb08ab9eca31273c0523a5c90de1f30a9
ToppCell	facs-Lung-3m\|Lung / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DCAF6 IQSEC1 PAN3 NR1D2	2.65e-04	195	71	4	c4648c0332c3826776f9ad3f5f803dbac2b4c0c0
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_basal-Dividing_Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KIF20A LAMA1 GRIK3 NKAP	2.65e-04	195	71	4	5812b1615676f3b77eb4769216b98b360c417c0d
ToppCell	healthy_donor-Lymphocytic-T_cell-CD8+_Memory_T_cell\|healthy_donor / Disease condition, Lineage, Cell class and subclass	PTP4A2 ZBTB38 RAP2A CYFIP2	2.70e-04	196	71	4	af00c31612e4fe068e5fccae05368edba46bbd20
ToppCell	Mild/Remission-B_naive-2\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	INTS6 RPL6 PRXL2C RPL9	2.75e-04	197	71	4	0042716ba630e4d5142cca46fcb279a2e64370f2
ToppCell	mild-Lymphocytic-CD8_T_cells\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	PTP4A2 ZBTB38 RAP2A PLEK	2.75e-04	197	71	4	8b0e4012e25641c3bcd3e9911031e43d9dbbff21
ToppCell	tumor_Lung-Fibroblasts-Smooth_muscle_cells\|Fibroblasts / Location, Cell class and cell subclass	PRUNE2 TLN1 LPP CYFIP2	2.81e-04	198	71	4	f540f464118edc0fb809ebcb813d0302e6952253
ToppCell	Tracheal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	PRUNE2 LPP CAPN6 SPDYE3	2.81e-04	198	71	4	cbb63b255bdc92a557c5db1f08f7766ed9346607
ToppCell	mild-Lymphocytic-CD8_T_cells\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	PTP4A2 ZBTB38 RPL6 RPL9	2.81e-04	198	71	4	629a1229759f3088cafb36f27a3d19d7249aab3a
ToppCell	Mild/Remission-B_naive-2\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	INTS6 RPL6 PRXL2C RPL9	2.81e-04	198	71	4	d238ad320e1989da01c48587f79eaeaa469cfa28
ToppCell	severe-Lymphocytic-CD8_T_cells\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	ZBTB38 RAP2A RPL6 RPL9	2.81e-04	198	71	4	2cd13418396ab2c53b1be96e7795841c2482bfca
ToppCell	normal_Lung-Fibroblasts-Smooth_muscle_cells\|Fibroblasts / Location, Cell class and cell subclass	PRUNE2 TLN1 LPP CYFIP2	2.86e-04	199	71	4	d65847ceb68a560798df3f73e6f838e7c3e38a1c
ToppCell	Mild/Remission-B_naive-9\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	INTS6 ADPRM RPL6 RPL9	2.86e-04	199	71	4	e9af3c6a05f435ac8d7066f54feb653012b51ffb
ToppCell	TCGA-Colorectal-Primary_Tumor\|TCGA-Colorectal / Sample_Type by Project: Shred V9	KIF20A CBX4 PPM1H CBX8	2.86e-04	199	71	4	c7d6a8398f2419b726a0461585d1ee0561654e3b
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c07-TYROBP\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	RAP2A RAP2B TLN1 PLEK	2.86e-04	199	71	4	63e632b06e13d2bcde5a00a51962bafdf60fd6c6
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	PTP4A2 ZBTB38 RPL6 RPL9	2.86e-04	199	71	4	c142c2e5874b811991905ed46f9c5a67a811e8a0
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal-6\|World / Primary Cells by Cluster	PRDM8 ZBTB38 RPL6 RPL9	2.86e-04	199	71	4	1b1bccf4293f11048709d15a3c892c0edf3da3d2
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW16-Neuronal-Neurons\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	PRDM8 SPIRE1 RPL6 RPL9	2.86e-04	199	71	4	ae575ed7582f2a4218f6cbcbf5f7f0ce7a5bc26b
ToppCell	TCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma\|TCGA-Colorectal / Sample_Type by Project: Shred V9	KIF20A CBX4 PPM1H CBX8	2.86e-04	199	71	4	85b3b1ad01368dae4adbc9da7efc148e49992f69
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal\|World / Primary Cells by Cluster	PRDM8 ZBTB38 RPL6 RPL9	2.86e-04	199	71	4	4bee94c116c0da5eba951cb4cea7cc9dcdd6e30f
ToppCell	Tracheal\|World / Cell types per location group and 10X technology with lineage, and cell group designations	DLG5 PLCB4 PPM1H SLC5A1	2.92e-04	200	71	4	682960e28542a3d6c119047cd0131941932cfdea
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-T/NK-gd_T\|COVID-19_Severe / Disease, condition lineage and cell class	ZBTB38 RAP2A PLEK CYFIP2	2.92e-04	200	71	4	f72bc3f6606ae77fe1b0a972e35b3ce0727804d9
Disease	Herpetic meningoencephalitis	TBK1 UNC93B1	8.03e-05	6	69	2	C0019385
Disease	Herpes encephalitis	TBK1 UNC93B1	1.12e-04	7	69	2	C0276226
Disease	gestational age	ZBTB38 RAP2C MRPS22 SENP5	3.13e-04	138	69	4	EFO_0005112
Disease	brain disease (is_implicated_in)	TBK1 UNC93B1	3.50e-04	12	69	2	DOID:936 (is_implicated_in)
Disease	protein-glutamine gamma-glutamyltransferase e measurement	DLG5 RP1 CYFIP2	3.81e-04	60	69	3	EFO_0020690
Disease	hematologic cancer (implicated_via_orthology)	PIAS3 PIAS1	4.13e-04	13	69	2	DOID:2531 (implicated_via_orthology)
Disease	Rheumatoid Arthritis	RAP2A HOXD13 IRAK1 PLEK	7.49e-04	174	69	4	C0003873

Protein segments in the cluster

Peptide	Gene	Start	Entry
ISRPDIRIGRYRMIK	B4GALT2	296	O60909
RILCMLYVPVEEKRR	ARHGEF10	956	O15013
TMKPKKQYRRRLREE	CDK12	971	Q9NYV4
YESEIKGKIRQRIMP	CEP19	21	Q96LK0
RPMKQPAVYIRIKNR	CRYBG3	2831	Q68DQ2
LKGRGRVPDRIMNYK	ADPRM	321	Q3LIE5
TLNIRRPLVKMVYKG	DCAF6	701	Q58WW2
AMVPELRKKSRREYL	DHX16	221	O60231
MRLKGQDIPKYFRLE	CC2D2B	696	Q6DHV5
GPRYKRSKIERRMNI	ATP10B	301	O94823
MRDQIIRVKRYEKVP	RAP2A	96	P10114
MRDQIIRVKRYERVP	RAP2B	96	P61225
IRVKRYERVPMILVG	RAP2B	101	P61225
MRDQIVRVKRYEKVP	RAP2C	96	Q9Y3L5
IMKEIRKPGRKYERI	INTS6	816	Q9UL03
RERPRPRKDMYEKMV	ITPKC	501	Q96DU7
RLLAEGKKPRQRYME	KCNJ5	41	P48544
RRKGYDQIIPKMLKT	POGLUT1	376	Q8NBL1
PKMVVLDAGRYQKLR	MAEL	336	Q96JY0
ERPGERRQAEMKRLY	GEMIN8	191	Q9NWZ8
AETKVRPLERRKYML	HIPK4	271	Q8NE63
PREMLMGIYERIRKR	IQSEC1	696	Q6DN90
GPRRNKEIMYRITTE	IKBKE	226	Q14164
KRKMAIKLRNEYGPV	PLRG1	41	O43660
IRRAYRNKAREPMEL	PDZD7	931	Q9H5P4
EMLKPRDGVRLKVQY	DLG5	1566	Q8TDM6
KPIMERILRATGKAY	LPP	481	Q93052
RLEVRMKRLEAKYAP	CYFIP2	1066	Q96F07
KRRPPMTQVYERLEK	IRAK1	506	P51617
KMRVIPDNRKYPELV	PCDHB11	181	Q9Y5F2
SQRRKPRKYRLGMLE	PAN3	226	Q58A45
LLKRRIRKGRMEYLV	CBX8	16	Q9HC52
ILPQLERERMAYGIK	LIG4	71	P49917
NQPDMCVYRRGRKKR	HOXD13	266	P35453
ERQEQLMGYRKRGPK	CBX4	61	O00257
KPGMKRQRSLYREIL	DENND4C	1836	Q5VZ89
RQVKEMEGILKRRYP	CEP162	926	Q5TB80
RIIYRKQEMERNEIP	FAM169A	121	Q9Y6X4
QGYVKRRDDRPQILM	CUL9	1936	Q8IWT3
PLLKEMKRGREFRII	GRIK3	216	Q13003
IYIGRKRMQVKEPEK	COLGALT2	466	Q8IYK4
KVYMVRLRNPLGRQE	CAPN6	276	Q9Y6Q1
RPVKIEKELSGMYRR	BVES	116	Q8NE79
MAEYVKAGKRIPRRG	NKAP	321	Q8N5F7
MQRPVVKLYATDGRR	RP1	191	P56715
FGRIPKREKQRMLIE	NR1D2	176	Q14995
YDTPRMVLVRNKKVG	P2RX1	16	P51575
RMIQVYFPKEGRKIL	MRPS22	191	P82650
KRQMSRIYPKGGRVD	PLCB4	616	Q15147
EQRIDMKVIEPYRRV	PRUNE2	2891	Q8WUY3
RRRPYWEKDIIKMLG	MRPL30	76	Q8TCC3
MEPKRIREGYLVKKG	PLEK	1	P08567
KGGRIRKQVIYMDAP	LAMA1	1261	P25391
EYAMEPLVKRRREEK	PRDM8	651	Q9NQV8
DKRRRIPGKTYMIIA	SLC35B3	136	Q9H1N7
PAVQMKIKELYRRRF	PIAS1	51	O75925
VGRMAIKPAVLKDYR	CYB5R4	126	Q7L1T6
PEREIYKRLGMKRGE	PRXL2C	121	Q7RTV5
PSVQMKIKELYRRRF	PIAS3	51	Q9Y6X2
DMPRVRKRIYKELCE	SENP5	736	Q96HI0
YLRMEQKLRRGVAPR	UNC93B1	511	Q9H1C4
NGGTRVVKLRKMPRY	RPL6	101	Q02878
PRRVQRKELGKKMLY	PPM1H	336	Q9ULR3
NFLGEKYIRRVRMRP	RPL9	116	P32969
SMEKVKVYLRVRPLL	KIF20A	61	O95235
YRKKQRPLKIRMLDG	TLN1	81	Q9Y490
LEKYRPKMRLRFRDT	PTP4A2	146	Q12974
MKAKRRRVSLVLPEY	SPDYE3	86	A6NKU9
KRYTLRKVMVNGDIP	SPIRE1	316	Q08AE8
IPMLIRRKETKDYGT	UMPS	91	P11172
KRGRRPKYQMQEEPL	ZBTB38	861	Q8NAP3
IKAGVVTMPEYLRKR	SLC5A1	121	P13866
GPRRNKEVMYKIITG	TBK1	226	Q9UHD2