Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	inner cell mass cell fate commitment	LATS1 LATS2	9.90e-06	3	38	2	GO:0001827
GeneOntologyBiologicalProcess	inner cell mass cellular morphogenesis	LATS1 LATS2	9.90e-06	3	38	2	GO:0001828
GeneOntologyBiologicalProcess	dorsal/ventral pattern formation	HHIP DSCAML1 TLL2 CAPRIN2	4.41e-05	107	38	4	GO:0009953
GeneOntologyBiologicalProcess	inner cell mass cell differentiation	LATS1 LATS2	9.19e-05	8	38	2	GO:0001826
Domain	Pkinase_C	LATS1 LATS2 RPS6KA1	4.48e-05	37	35	3	IPR017892
Domain	Pkinase_C	LATS1 LATS2 RPS6KA1	6.58e-05	42	35	3	PF00433
Domain	AGC-kinase_C	LATS1 LATS2 RPS6KA1	1.56e-04	56	35	3	IPR000961
Domain	AGC_KINASE_CTER	LATS1 LATS2 RPS6KA1	1.56e-04	56	35	3	PS51285
Domain	S_TK_X	LATS1 LATS2 RPS6KA1	1.56e-04	56	35	3	SM00133
Domain	Ig_I-set	OBSCN NEO1 MXRA5 DSCAML1	4.25e-04	190	35	4	IPR013098
Domain	I-set	OBSCN NEO1 MXRA5 DSCAML1	4.25e-04	190	35	4	PF07679
Domain	IGc2	OBSCN NEO1 MXRA5 DSCAML1	9.42e-04	235	35	4	SM00408
Domain	Ig_sub2	OBSCN NEO1 MXRA5 DSCAML1	9.42e-04	235	35	4	IPR003598
Domain	UBA	LATS1 LATS2	2.07e-03	36	35	2	PF00627
Domain	Sulfotransferase_dom	NDST4 CHST3	2.07e-03	36	35	2	IPR000863
Domain	Sulfotransfer_1	NDST4 CHST3	2.07e-03	36	35	2	PF00685
Domain	UBA	LATS1 LATS2	3.07e-03	44	35	2	IPR015940
Domain	Kinase-like_dom	OBSCN LATS1 LATS2 RAPH1 RPS6KA1	3.19e-03	542	35	5	IPR011009
Domain	fn3	OBSCN NEO1 DSCAML1	3.42e-03	162	35	3	PF00041
Domain	UBA	LATS1 LATS2	3.50e-03	47	35	2	PS50030
Domain	Ser/Thr_kinase_AS	OBSCN LATS1 LATS2 RPS6KA1	4.31e-03	357	35	4	IPR008271
Domain	S_TKc	OBSCN LATS1 LATS2 RPS6KA1	4.39e-03	359	35	4	SM00220
Domain	PROTEIN_KINASE_ST	OBSCN LATS1 LATS2 RPS6KA1	4.52e-03	362	35	4	PS00108
Domain	FN3	OBSCN NEO1 DSCAML1	4.96e-03	185	35	3	SM00060
Domain	Pkinase	OBSCN LATS1 LATS2 RPS6KA1	5.42e-03	381	35	4	PF00069
Domain	-	OBSCN CADPS2 DCP1B RAPH1	5.93e-03	391	35	4	2.30.29.30
Domain	FN3	OBSCN NEO1 DSCAML1	6.07e-03	199	35	3	PS50853
Domain	UBA-like	LATS1 LATS2	6.39e-03	64	35	2	IPR009060
Domain	FN3_dom	OBSCN NEO1 DSCAML1	6.95e-03	209	35	3	IPR003961
Domain	IG	OBSCN NEO1 MXRA5 DSCAML1	7.67e-03	421	35	4	SM00409
Domain	Ig_sub	OBSCN NEO1 MXRA5 DSCAML1	7.67e-03	421	35	4	IPR003599
Domain	PH_dom-like	OBSCN CADPS2 DCP1B RAPH1	7.99e-03	426	35	4	IPR011993
Domain	IGv	OBSCN DSCAML1	8.69e-03	75	35	2	SM00406
Domain	PH	OBSCN CADPS2 RAPH1	8.92e-03	229	35	3	PF00169
Domain	PROTEIN_KINASE_ATP	OBSCN LATS1 LATS2 RPS6KA1	1.03e-02	459	35	4	PS00107
Pubmed	Association analysis between SNPs in LATS1 and LATS2 and non-cardia gastric cancer.	LATS1 LATS2	1.23e-06	2	39	2	32423384
Pubmed	Deletion of Lats1/2 in adult kidney epithelia leads to renal cell carcinoma.	LATS1 LATS2	1.23e-06	2	39	2	34060480
Pubmed	Mutation analysis of large tumor suppressor genes LATS1 and LATS2 supports a tumor suppressor role in human cancer.	LATS1 LATS2	1.23e-06	2	39	2	25482410
Pubmed	Cell type-dependent function of LATS1/2 in cancer cell growth.	LATS1 LATS2	1.23e-06	2	39	2	30531839
Pubmed	Lats1/2-Mediated Alteration of Hippo Signaling Pathway Regulates the Fate of Bone Marrow-Derived Mesenchymal Stem Cells.	LATS1 LATS2	1.23e-06	2	39	2	30671453
Pubmed	Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers.	LATS1 LATS2	1.23e-06	2	39	2	15746036
Pubmed	Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma.	LATS1 LATS2	1.23e-06	2	39	2	17049657
Pubmed	Identification of LATS transcriptional targets in HeLa cells using whole human genome oligonucleotide microarray.	LATS1 LATS2	1.23e-06	2	39	2	19799973
Pubmed	LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function.	LATS1 LATS2	1.23e-06	2	39	2	31848340
Pubmed	Expression of LATS family proteins in ovarian tumors and its significance.	LATS1 LATS2	1.23e-06	2	39	2	25841306
Pubmed	Lats1 and Lats2 are required for ovarian granulosa cell fate maintenance.	LATS1 LATS2	1.23e-06	2	39	2	31268774
Pubmed	LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control.	LATS1 LATS2	1.23e-06	2	39	2	32015438
Pubmed	A single copy of large tumor suppressor 1 or large tumor suppressor 2 is sufficient for normal hematopoiesis.	LATS1 LATS2	1.23e-06	2	39	2	32826458
Pubmed	A novel immuno-competitive capture mass spectrometry strategy for protein-protein interaction profiling reveals that LATS kinases regulate HCV replication through NS5A phosphorylation.	LATS1 LATS2	1.23e-06	2	39	2	25044019
Pubmed	AICAR Antiproliferative Properties Involve the AMPK-Independent Activation of the Tumor Suppressors LATS 1 and 2.	LATS1 LATS2	1.23e-06	2	39	2	29730476
Pubmed	WWP1 E3 ligase targets LATS1 for ubiquitin-mediated degradation in breast cancer cells.	LATS1 WWP1	1.23e-06	2	39	2	23573293
Pubmed	The Hippo pathway regulates human megakaryocytic differentiation.	LATS1 LATS2	1.23e-06	2	39	2	27786336
Pubmed	Evidence for a tumor suppressor role for the large tumor suppressor genes LATS1 and LATS2 in human cancer.	LATS1 LATS2	1.23e-06	2	39	2	24026096
Pubmed	N-terminal truncation of Lats1 causes abnormal cell growth control and chromosomal instability.	LATS1 LATS2	1.23e-06	2	39	2	23230145
Pubmed	A FUS-LATS1/2 Axis Inhibits Hepatocellular Carcinoma Progression via Activating Hippo Pathway.	LATS1 LATS2	3.67e-06	3	39	2	30308519
Pubmed	Negative regulation of YAP by LATS1 underscores evolutionary conservation of the Drosophila Hippo pathway.	LATS1 LATS2	3.67e-06	3	39	2	18413746
Pubmed	Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2.	LATS1 LATS2	3.67e-06	3	39	2	24012335
Pubmed	Tumor suppressor LATS1 is a negative regulator of oncogene YAP.	LATS1 LATS2	3.67e-06	3	39	2	18158288
Pubmed	LATS kinases and SLUG regulate the transition to advanced stage in aggressive oral cancer cells.	LATS1 LATS2	3.67e-06	3	39	2	35859006
Pubmed	Hippo signalling maintains ER expression and ER+ breast cancer growth.	LATS1 LATS2	7.34e-06	4	39	2	33658690
Pubmed	Heat shock protein 90 inhibition depletes LATS1 and LATS2, two regulators of the mammalian hippo tumor suppressor pathway.	LATS1 LATS2	7.34e-06	4	39	2	20841485
Pubmed	WWC1 and NF2 Prevent the Development of Intrahepatic Cholangiocarcinoma by Regulating YAP/TAZ Activity through LATS in Mice.	LATS1 LATS2	7.34e-06	4	39	2	32451369
Pubmed	KIBRA regulates Hippo signaling activity via interactions with large tumor suppressor kinases.	LATS1 LATS2	7.34e-06	4	39	2	21233212
Pubmed	Src Inhibits the Hippo Tumor Suppressor Pathway through Tyrosine Phosphorylation of Lats1.	LATS1 LATS2	7.34e-06	4	39	2	28754671
Pubmed	The tumor suppressor Lats2 is pivotal in Aurora A and Aurora B signaling during mitosis.	LATS1 LATS2	7.34e-06	4	39	2	21822051
Pubmed	Phosphorylation of CHO1 by Lats1/2 regulates the centrosomal activation of LIMK1 during cytokinesis.	LATS1 LATS2	7.34e-06	4	39	2	25786116
Pubmed	RASSF1A-Mediated Suppression of Estrogen Receptor Alpha (ERα)-Driven Breast Cancer Cell Growth Depends on the Hippo-Kinases LATS1 and 2.	LATS1 LATS2	7.34e-06	4	39	2	34831091
Pubmed	Binding of Kif23-iso1/CHO1 to 14-3-3 is regulated by sequential phosphorylations at two LATS kinase consensus sites.	LATS1 LATS2	7.34e-06	4	39	2	25658096
Pubmed	Hippo signaling instructs ectopic but not normal organ growth.	LATS1 LATS2	7.34e-06	4	39	2	36395225
Pubmed	Inactivation of the Hippo tumor suppressor pathway promotes melanoma.	LATS1 LATS2	7.34e-06	4	39	2	35768444
Pubmed	Lats2/Kpm is required for embryonic development, proliferation control and genomic integrity.	LATS1 LATS2	7.34e-06	4	39	2	15343267
Pubmed	Cytoplasmic ASPP1 inhibits apoptosis through the control of YAP.	LATS1 LATS2	7.34e-06	4	39	2	21041411
Pubmed	YAP/TAZ and Hedgehog Coordinate Growth and Patterning in Gastrointestinal Mesenchyme.	HHIP LATS1 LATS2	9.07e-06	36	39	3	28943241
Pubmed	Myofibroblast YAP/TAZ activation is a key step in organ fibrogenesis.	LATS1 LATS2	1.22e-05	5	39	2	35191398
Pubmed	Homeostatic control of Hippo signaling activity revealed by an endogenous activating mutation in YAP.	LATS1 LATS2	1.22e-05	5	39	2	26109051
Pubmed	Distinct fibroblast subsets regulate lacteal integrity through YAP/TAZ-induced VEGF-C in intestinal villi.	LATS1 LATS2	1.22e-05	5	39	2	32796823
Pubmed	Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse.	LATS1 LATS2	1.22e-05	5	39	2	31474569
Pubmed	YAP/TAZ-CDC42 signaling regulates vascular tip cell migration.	LATS1 LATS2	1.22e-05	5	39	2	28973878
Pubmed	Phosphorylation of angiomotin by Lats1/2 kinases inhibits F-actin binding, cell migration, and angiogenesis.	LATS1 LATS2	1.22e-05	5	39	2	24106267
Pubmed	Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis.	LATS1 LATS2	1.22e-05	5	39	2	29438698
Pubmed	The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα.	LATS1 LATS2	1.22e-05	5	39	2	28068668
Pubmed	The Hippo Pathway Blocks Mammalian Retinal Müller Glial Cell Reprogramming.	LATS1 LATS2	1.22e-05	5	39	2	31067451
Pubmed	Mst2 and Lats kinases regulate apoptotic function of Yes kinase-associated protein (YAP).	LATS1 LATS2	1.22e-05	5	39	2	18640976
Pubmed	Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway.	LATS1 LATS2	1.22e-05	5	39	2	26045165
Pubmed	The Hippo pathway links adipocyte plasticity to adipose tissue fibrosis.	LATS1 LATS2	1.22e-05	5	39	2	36229481
Pubmed	Control of skeletal morphogenesis by the Hippo-YAP/TAZ pathway.	LATS1 LATS2	1.22e-05	5	39	2	32994166
Pubmed	Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases.	LATS1 LATS2	1.22e-05	5	39	2	20624913
Pubmed	YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation.	LATS1 LATS2	1.22e-05	5	39	2	28805663
Pubmed	Ajuba LIM proteins are negative regulators of the Hippo signaling pathway.	LATS1 LATS2	1.83e-05	6	39	2	20303269
Pubmed	Hippo pathway deletion in adult resting cardiac fibroblasts initiates a cell state transition with spontaneous and self-sustaining fibrosis.	LATS1 LATS2	1.83e-05	6	39	2	31558567
Pubmed	The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1.	LATS1 LATS2	1.83e-05	6	39	2	15688006
Pubmed	Lysine demethylase 2 (KDM2B) regulates hippo pathway via MOB1 to promote pancreatic ductal adenocarcinoma (PDAC) progression.	LATS1 LATS2	1.83e-05	6	39	2	31941533
Pubmed	Hippo Signaling Plays an Essential Role in Cell State Transitions during Cardiac Fibroblast Development.	LATS1 LATS2	1.83e-05	6	39	2	29689192
Pubmed	Angiomotins stimulate LATS kinase autophosphorylation and act as scaffolds that promote Hippo signaling.	LATS1 LATS2	1.83e-05	6	39	2	30266805
Pubmed	cAMP/PKA signalling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes.	LATS1 LATS2	1.83e-05	6	39	2	23644383
Pubmed	Serum deprivation inhibits the transcriptional co-activator YAP and cell growth via phosphorylation of the 130-kDa isoform of Angiomotin by the LATS1/2 protein kinases.	LATS1 LATS2	1.83e-05	6	39	2	24101513
Pubmed	Hippo-YAP/TAZ signalling coordinates adipose plasticity and energy balance by uncoupling leptin expression from fat mass.	LATS1 LATS2	1.83e-05	6	39	2	38811804
Pubmed	The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass.	LATS1 LATS2	1.83e-05	6	39	2	19289085
Pubmed	Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas.	LATS1 LATS2	1.83e-05	6	39	2	36443313
Pubmed	Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell.	LATS1 LATS2	1.83e-05	6	39	2	31019301
Pubmed	YAP Mediates Hair Cell Regeneration in Balance Organs of Chickens, But LATS Kinases Suppress Its Activity in Mice.	LATS1 LATS2	1.83e-05	6	39	2	32341094
Pubmed	Activation of the intrinsic fibroinflammatory program in adult pancreatic acinar cells triggered by Hippo signaling disruption.	LATS1 LATS2	1.83e-05	6	39	2	31513574
Pubmed	Deficiency of large tumor suppressor kinase 1 causes congenital hearing loss associated with cochlear abnormalities in mice.	LATS1 LATS2	2.56e-05	7	39	2	33162027
Pubmed	Hippo signaling impedes adult heart regeneration.	LATS1 LATS2	2.56e-05	7	39	2	24255096
Pubmed	YAP/TAZ Initiates Gastric Tumorigenesis via Upregulation of MYC.	LATS1 LATS2	2.56e-05	7	39	2	29669762
Pubmed	YAP1/TAZ drives ependymoma-like tumour formation in mice.	LATS1 LATS2	2.56e-05	7	39	2	32404936
Pubmed	Actin-binding and cell proliferation activities of angiomotin family members are regulated by Hippo pathway-mediated phosphorylation.	LATS1 LATS2	2.56e-05	7	39	2	24225952
Pubmed	YAP and AP-1 Cooperate to Initiate Pancreatic Cancer Development from Ductal Cells in Mice.	LATS1 LATS2	2.56e-05	7	39	2	32900774
Pubmed	YAP/TAZ Activation Drives Uveal Melanoma Initiation and Progression.	LATS1 LATS2	2.56e-05	7	39	2	31801083
Pubmed	Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice.	LATS1 LATS2	2.56e-05	7	39	2	31754005
Pubmed	Schwannoma development is mediated by Hippo pathway dysregulation and modified by RAS/MAPK signaling.	LATS1 LATS2	2.56e-05	7	39	2	32960816
Pubmed	YAP and TAZ Negatively Regulate Prox1 During Developmental and Pathologic Lymphangiogenesis.	LATS1 LATS2	2.56e-05	7	39	2	30582452
Pubmed	Molecular characterization of human homologs of yeast MOB1.	LATS1 LATS2	3.42e-05	8	39	2	19739119
Pubmed	A Stk4-Foxp3-NF-κB p65 transcriptional complex promotes Treg cell activation and homeostasis.	LATS1 LATS2	3.42e-05	8	39	2	36149942
Pubmed	Hippo/Mst signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions.	LATS1 LATS2	3.42e-05	8	39	2	32289155
Pubmed	Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription.	LATS1 LATS2	3.42e-05	8	39	2	32259481
Pubmed	Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus.	LATS1 LATS2	3.42e-05	8	39	2	25026211
Pubmed	AMOTL2 mono-ubiquitination by WWP1 promotes contact inhibition by facilitating LATS activation.	LATS2 WWP1	3.42e-05	8	39	2	34404733
Pubmed	Evolutionary and molecular facts link the WWC protein family to Hippo signaling.	LATS1 LATS2	3.42e-05	8	39	2	24682284
Pubmed	Confirmed rare copy number variants implicate novel genes in schizophrenia.	SGCE SP4	4.39e-05	9	39	2	20298200
Pubmed	Hippo Signaling Mediators Yap and Taz Are Required in the Epicardium for Coronary Vasculature Development.	LATS1 LATS2	4.39e-05	9	39	2	27160901
Pubmed	Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling.	LATS1 LATS2	4.39e-05	9	39	2	22863277
Pubmed	The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals.	LATS1 LATS2	4.39e-05	9	39	2	20643348
Pubmed	SDCBP promotes pancreatic cancer progression by preventing YAP1 from β-TrCP-mediated proteasomal degradation.	LATS1 LATS2	4.39e-05	9	39	2	36828627
Pubmed	Spatiotemporal Loss of NF1 in Schwann Cell Lineage Leads to Different Types of Cutaneous Neurofibroma Susceptible to Modification by the Hippo Pathway.	LATS1 LATS2	5.48e-05	10	39	2	30348677
Pubmed	The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland.	LATS1 LATS2	6.70e-05	11	39	2	28492365
Pubmed	Inactivation of Lats1 and Lats2 highlights the role of hippo pathway effector YAP in larynx and vocal fold epithelium morphogenesis.	LATS1 LATS2	6.70e-05	11	39	2	33515576
Pubmed	The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity.	LATS1 LATS2	6.70e-05	11	39	2	27912060
Pubmed	LATS1/2 control TGFB-directed epithelial-to-mesenchymal transition in the murine dorsal cranial neuroepithelium through YAP regulation.	LATS1 LATS2	6.70e-05	11	39	2	36125128
Pubmed	Hippo/Mst signalling couples metabolic state and immune function of CD8α+ dendritic cells.	LATS1 LATS2	6.70e-05	11	39	2	29849151
Pubmed	Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2.	LATS1 LATS2	6.70e-05	11	39	2	28486106
Pubmed	The Hippo pathway kinases LATS1 and LATS2 attenuate cellular responses to heavy metals through phosphorylating MTF1.	LATS1 LATS2	8.03e-05	12	39	2	35027733
Pubmed	NEDD4 E3 ligase inhibits the activity of the Hippo pathway by targeting LATS1 for degradation.	LATS1 WWP1	8.03e-05	12	39	2	24107629
Pubmed	WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy.	LATS1 LATS2	8.03e-05	12	39	2	35429439
Pubmed	Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase.	LATS1 LATS2	8.03e-05	12	39	2	25438054
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	OBSCN NEO1 MXRA5 DSCAML1	5.60e-05	161	24	4	593
GeneFamily	Sulfotransferases, membrane bound	NDST4 CHST3	1.09e-03	37	24	2	763
GeneFamily	Fibronectin type III domain containing	OBSCN NEO1 DSCAML1	1.20e-03	160	24	3	555
GeneFamily	Immunoglobulin like domain containing	NEO1 MXRA5 DSCAML1	2.05e-03	193	24	3	594
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	CADPS2 RAPH1	3.02e-02	206	24	2	682
Disease	benign neoplasm (implicated_via_orthology)	LATS1 LATS2	4.50e-05	8	38	2	DOID:0060072 (implicated_via_orthology)
Disease	kidney cancer (implicated_via_orthology)	LATS1 LATS2	8.82e-05	11	38	2	DOID:263 (implicated_via_orthology)
Disease	autosomal dominant polycystic kidney disease (implicated_via_orthology)	KIF28P LATS1	1.46e-04	14	38	2	DOID:898 (implicated_via_orthology)
Disease	Pilocytic Astrocytoma	LATS1 LATS2	4.75e-04	25	38	2	C0334583
Disease	Cerebral Astrocytoma	LATS1 LATS2	4.75e-04	25	38	2	C0750935
Disease	Intracranial Astrocytoma	LATS1 LATS2	4.75e-04	25	38	2	C0750936
Disease	Astrocytoma	LATS1 LATS2	4.75e-04	25	38	2	C0004114
Disease	Juvenile Pilocytic Astrocytoma	LATS1 LATS2	4.75e-04	25	38	2	C0280783
Disease	Diffuse Astrocytoma	LATS1 LATS2	4.75e-04	25	38	2	C0280785
Disease	Grade I Astrocytoma	LATS1 LATS2	4.75e-04	25	38	2	C1704230
Disease	Subependymal Giant Cell Astrocytoma	LATS1 LATS2	4.75e-04	25	38	2	C0205768
Disease	Mixed oligoastrocytoma	LATS1 LATS2	4.75e-04	25	38	2	C0547065
Disease	Childhood Cerebral Astrocytoma	LATS1 LATS2	4.75e-04	25	38	2	C0338070
Disease	Gemistocytic astrocytoma	LATS1 LATS2	5.15e-04	26	38	2	C0334581
Disease	Protoplasmic astrocytoma	LATS1 LATS2	5.15e-04	26	38	2	C0334580
Disease	Fibrillary Astrocytoma	LATS1 LATS2	5.15e-04	26	38	2	C0334582
Disease	Anaplastic astrocytoma	LATS1 LATS2	5.55e-04	27	38	2	C0334579
Disease	neurodegenerative disease (implicated_via_orthology)	LATS1 LATS2 GGA1	8.64e-04	145	38	3	DOID:1289 (implicated_via_orthology)
Disease	autism spectrum disorder (implicated_via_orthology)	NDST4 CADPS2 DSCAML1	9.91e-04	152	38	3	DOID:0060041 (implicated_via_orthology)
Disease	total hip arthroplasty, osteoarthritis	HHIP CHST3	1.35e-03	42	38	2	EFO_0009806, MONDO_0005178
Disease	Abnormality of refraction	CCAR2 HHIP ABCA4 LATS2 DSCAML1	1.64e-03	673	38	5	HP_0000539
Disease	pain	SP4 LATS1 CHST3	2.05e-03	196	38	3	EFO_0003843
Disease	body mass index, osteoarthritis	CADPS2 RAPH1	2.22e-03	54	38	2	EFO_0004340, MONDO_0005178

Protein segments in the cluster

Peptide	Gene	Start	Entry
VPWNAVKVQTLSNQP	CCAR2	106	Q8N163
PKHSLKQTQPTVNWV	EPS15L1	256	Q9UBC2
KQTQPTVNWVVPVAD	EPS15L1	261	Q9UBC2
WKTPSVSPNITQLFQ	ABCA4	1461	P78363
LNSTAIKPQVQPWIN	COG4	611	Q9H9E3
QNASKVAQIPSPWVS	AFF2	1191	P51816
PNQNKIWTVTVSPEQ	ABHD4	51	Q8TB40
WENPNVEPSKVNLQV	BTBD11	481	A6QL63
VAVVNPQPQQWSKMS	RAPH1	1101	Q70E73
KVINWQTSLHIPPQA	LATS1	961	O95835
PTPTETQLKVINWEN	LATS2	916	Q9NRM7
VPLNVPNNKNSTEWE	LMBRD1	161	Q9NUN5
QPWQTSAPQNTTQPK	MS4A10	26	Q96PG2
PPESQQVRWEKQQPT	GGA1	436	Q9UJY5
QSWTNLKLQTLPPVQ	NDST4	541	Q9H3R1
NPTPQVSWEKDQQPV	OBSCN	36	Q5VST9
NIWKETVPQTLRPQT	B3GALT2	81	O43825
ESWINKTPNTEQQTP	DCP1B	491	Q8IZD4
QPPVAKLWTSQEQPQ	CCDC200	61	A0A1B0GVQ3
KLWTSQEQPQPSQQQ	CCDC200	66	A0A1B0GVQ3
QNPSVSVQTSQDWKP	CBX2	481	Q14781
QPVTSQSIQVTWKAP	DSCAML1	996	Q8TD84
KETQPPETVQNWIEL	GOLPH3	141	Q9H4A6
QETWQPVKNIANSLP	CADPS2	956	Q86UW7
QETPKLWPVQLQKEQ	CAPRIN2	491	Q6IMN6
QPETPKSWENNVESQ	CAPRIN2	541	Q6IMN6
FQPWVNPKVEQEVSS	KIAA1210	951	Q9ULL0
SEPVWDMTTQKVQQQ	CCDC168	6296	Q8NDH2
VIQTPQPWVIQSSEI	CREM	71	Q03060
PVWKSVNPQIEETVQ	KIF28P	741	B7ZC32
LTPSGQISWQTVQVQ	SP4	461	Q02446
LPTKQEPSWINQSEQ	NHS	906	Q6T4R5
VTSIVVSWTPPENQN	NEO1	751	Q92859
VVAKKSPTHQQIWNP	CCT8L1P	521	A6NM43
PEEVQTVDPQSVQKW	MED13	331	Q9UHV7
LQQSPVTKQWQEKPL	HHIP	521	Q96QV1
PHQTQIPQQQTTGKW	SGCE	421	O43556
IPLTPQVEDWIQKNT	CHST3	391	Q7LGC8
PTNKNCVWQVVAPAQ	TLL2	641	Q9Y6L7
PVKWQENATPVTEQS	VWA3B	186	Q502W6
NPKWDEQLTVNVTPQ	WWP1	61	Q9H0M0
QHPWVTQKDKLPQSQ	RPS6KA1	671	Q15418
VPTAWVDNTVNTPKQ	MXRA5	1201	Q9NR99
PTVPQKLITINQQWK	NMES1	56	Q9C002