Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	GLUD1 GLUD2	3.76e-05	2	123	2	GO:0016639
GeneOntologyMolecularFunction	glutamate dehydrogenase [NAD(P)+] activity	GLUD1 GLUD2	3.76e-05	2	123	2	GO:0004353
GeneOntologyMolecularFunction	glutamate dehydrogenase (NAD+) activity	GLUD1 GLUD2	3.76e-05	2	123	2	GO:0004352
GeneOntologyMolecularFunction	glutamate dehydrogenase (NADP+) activity	GLUD1 GLUD2	3.76e-05	2	123	2	GO:0004354
GeneOntologyMolecularFunction	methionine adenosyltransferase activity	MAT1A MAT2A	3.76e-05	2	123	2	GO:0004478
GeneOntologyMolecularFunction	interleukin-1 binding	A2M TRIM16L IL1R1	4.82e-05	12	123	3	GO:0019966
GeneOntologyMolecularFunction	choline kinase activity	CHKB ETNK2	1.12e-04	3	123	2	GO:0004103
GeneOntologyMolecularFunction	ethanolamine kinase activity	CHKB ETNK2	2.24e-04	4	123	2	GO:0004305
GeneOntologyMolecularFunction	ATP:ADP antiporter activity	SLC25A4 SLC25A6	3.72e-04	5	123	2	GO:0005471
GeneOntologyMolecularFunction	receptor-receptor interaction	HTR1A FGF20	3.72e-04	5	123	2	GO:0090722
GeneOntologyMolecularFunction	heparan sulfate proteoglycan binding	ITGA2 PTPRC FGF20	7.41e-04	29	123	3	GO:0043395
GeneOntologyMolecularFunction	L-leucine binding	GLUD1 GLUD2	7.75e-04	7	123	2	GO:0070728
GeneOntologyMolecularFunction	nerve growth factor binding	A2M PCSK6	1.03e-03	8	123	2	GO:0048406
GeneOntologyMolecularFunction	amino acid binding	MAT1A MAT2A GLUD1 GLUD2	1.07e-03	73	123	4	GO:0016597
GeneOntologyMolecularFunction	cell-matrix adhesion mediator activity	ITGA2 ITGA9	1.32e-03	9	123	2	GO:0098634
GeneOntologyCellularComponent	methionine adenosyltransferase complex	MAT1A MAT2A	1.06e-04	3	125	2	GO:0048269
Domain	RFX_DNA_binding	RFX6 RFX1 RFX2 RFX3	2.20e-07	9	123	4	PF02257
Domain	DNA-bd_RFX	RFX6 RFX1 RFX2 RFX3	2.20e-07	9	123	4	IPR003150
Domain	RFX_DBD	RFX6 RFX1 RFX2 RFX3	2.20e-07	9	123	4	PS51526
Domain	RFX1_trans_act	RFX1 RFX2 RFX3	2.79e-07	3	123	3	IPR007668
Domain	RFX1_trans_act	RFX1 RFX2 RFX3	2.79e-07	3	123	3	PF04589
Domain	ELFV_dehydrog_N	GLUD1 GLUD2	4.30e-05	2	123	2	PF02812
Domain	Glu/Leu/Phe/Val_DH_C	GLUD1 GLUD2	4.30e-05	2	123	2	IPR006096
Domain	Glu/Leu/Phe/Val_DH_dimer_dom	GLUD1 GLUD2	4.30e-05	2	123	2	IPR006097
Domain	Glu/Leu/Phe/Val_DH	GLUD1 GLUD2	4.30e-05	2	123	2	IPR006095
Domain	ELFV_dehydrog	GLUD1 GLUD2	4.30e-05	2	123	2	PF00208
Domain	S-AdoMet_synt_N	MAT1A MAT2A	4.30e-05	2	123	2	PF00438
Domain	NAD_bind_Glu_DH	GLUD1 GLUD2	4.30e-05	2	123	2	IPR033922
Domain	S-AdoMet_synthetase	MAT1A MAT2A	4.30e-05	2	123	2	IPR002133
Domain	GLFV_DEHYDROGENASE	GLUD1 GLUD2	4.30e-05	2	123	2	PS00074
Domain	S-AdoMet_synt_M	MAT1A MAT2A	4.30e-05	2	123	2	PF02772
Domain	S-AdoMet_synt_C	MAT1A MAT2A	4.30e-05	2	123	2	PF02773
Domain	ELFV_dehydrog	GLUD1 GLUD2	4.30e-05	2	123	2	SM00839
Domain	ADOMET_SYNTHASE_CS	MAT1A MAT2A	4.30e-05	2	123	2	IPR022631
Domain	S-AdoMet_synt_C	MAT1A MAT2A	4.30e-05	2	123	2	IPR022630
Domain	Glu/Leu/Phe/Val_DH_AS	GLUD1 GLUD2	4.30e-05	2	123	2	IPR033524
Domain	S-AdoMet_synthetase_sfam	MAT1A MAT2A	4.30e-05	2	123	2	IPR022636
Domain	S-AdoMet_synt_central	MAT1A MAT2A	4.30e-05	2	123	2	IPR022629
Domain	S-AdoMet_synt_N	MAT1A MAT2A	4.30e-05	2	123	2	IPR022628
Domain	ADOMET_SYNTHASE_1	MAT1A MAT2A	4.30e-05	2	123	2	PS00376
Domain	ADOMET_SYNTHASE_2	MAT1A MAT2A	4.30e-05	2	123	2	PS00377
Domain	SAA	SAA1 SAA2	2.56e-04	4	123	2	PS00992
Domain	SAA	SAA1 SAA2	2.56e-04	4	123	2	SM00197
Domain	SAA	SAA1 SAA2	2.56e-04	4	123	2	PF00277
Domain	Serum_amyloid_A	SAA1 SAA2	4.25e-04	5	123	2	IPR000096
Domain	-	LARP1 RFX6 RFX1 RFX2 RFX3 PIKFYVE EIF3C	6.06e-04	218	123	7	1.10.10.10
Domain	GF_recep_IV	PCSK5 PCSK6	6.34e-04	6	123	2	PF14843
Domain	GF_recep_IV	PCSK5 PCSK6	6.34e-04	6	123	2	IPR032778
Domain	Peptidase_S8_Asp-AS	PCSK5 PCSK6	6.34e-04	6	123	2	IPR023827
Domain	P_proprotein	PCSK5 PCSK6	8.84e-04	7	123	2	PF01483
Domain	S8_pro-domain	PCSK5 PCSK6	8.84e-04	7	123	2	IPR032815
Domain	PrprotnconvertsP	PCSK5 PCSK6	8.84e-04	7	123	2	IPR002884
Domain	-	PCSK5 PCSK6	8.84e-04	7	123	2	3.30.70.850
Domain	S8_pro-domain	PCSK5 PCSK6	8.84e-04	7	123	2	PF16470
Domain	WHTH_DNA-bd_dom	LARP1 RFX6 RFX1 RFX2 RFX3 PIKFYVE EIF3C	1.12e-03	242	123	7	IPR011991
Domain	Sel1	SEL1L SEL1L2	1.17e-03	8	123	2	PF08238
Domain	SEL1	SEL1L SEL1L2	1.17e-03	8	123	2	SM00671
Domain	A2M_N_2	A2M C5	1.17e-03	8	123	2	SM01359
Domain	-	A2M C5	1.17e-03	8	123	2	2.60.40.690
Domain	A2M_recep	A2M C5	1.17e-03	8	123	2	SM01361
Domain	A2M	A2M C5	1.17e-03	8	123	2	SM01360
Domain	C1Q	COL8A1 C1QB C1QTNF4	1.20e-03	32	123	3	SM00110
Domain	C1q	COL8A1 C1QB C1QTNF4	1.20e-03	32	123	3	PF00386
Domain	EGF-like_dom	PCSK5 ATRN LAMC1 FAT2 PCSK6 CNTNAP4 C8A	1.32e-03	249	123	7	IPR000742
Domain	-	PCSK5 LAMC1 PCSK6 CNTNAP4	1.37e-03	73	123	4	2.60.120.260
Domain	C1q_dom	COL8A1 C1QB C1QTNF4	1.44e-03	34	123	3	IPR001073
Domain	C1Q	COL8A1 C1QB C1QTNF4	1.44e-03	34	123	3	PS50871
Domain	Peptidase_S8_His-AS	PCSK5 PCSK6	1.50e-03	9	123	2	IPR022398
Domain	Peptidase_S8_Ser-AS	PCSK5 PCSK6	1.50e-03	9	123	2	IPR023828
Domain	Sel1-like	SEL1L SEL1L2	1.50e-03	9	123	2	IPR006597
Domain	A2M	A2M C5	1.87e-03	10	123	2	PF00207
Domain	A2M_N_2	A2M C5	1.87e-03	10	123	2	IPR011625
Domain	A2M_comp	A2M C5	1.87e-03	10	123	2	IPR011626
Domain	Rap_GAP	SIPA1L3 SIPA1	1.87e-03	10	123	2	PF02145
Domain	A2M_recep	A2M C5	1.87e-03	10	123	2	PF07677
Domain	A2M_comp	A2M C5	1.87e-03	10	123	2	PF07678
Domain	A2M_N	A2M C5	1.87e-03	10	123	2	PF01835
Domain	Peptidase_S8_subtilisin-rel	PCSK5 PCSK6	1.87e-03	10	123	2	IPR015500
Domain	A2M_N	A2M C5	1.87e-03	10	123	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	A2M C5	1.87e-03	10	123	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	A2M C5	1.87e-03	10	123	2	PS00477
Domain	A2M_N_2	A2M C5	1.87e-03	10	123	2	PF07703
Domain	SUBTILASE_ASP	PCSK5 PCSK6	1.87e-03	10	123	2	PS00136
Domain	SUBTILASE_HIS	PCSK5 PCSK6	1.87e-03	10	123	2	PS00137
Domain	SUBTILASE_SER	PCSK5 PCSK6	1.87e-03	10	123	2	PS00138
Domain	Macroglobln_a2	A2M C5	1.87e-03	10	123	2	IPR001599
Domain	-	PCSK5 PCSK6	2.28e-03	11	123	2	3.40.50.200
Domain	Rap_GAP_dom	SIPA1L3 SIPA1	2.28e-03	11	123	2	IPR000331
Domain	Peptidase_S8/S53_dom	PCSK5 PCSK6	2.28e-03	11	123	2	IPR000209
Domain	RAPGAP	SIPA1L3 SIPA1	2.28e-03	11	123	2	PS50085
Domain	Peptidase_S8	PCSK5 PCSK6	2.28e-03	11	123	2	PF00082
Domain	Peptidase_M28	ERMP1 QPCT	2.72e-03	12	123	2	PF04389
Domain	Peptidase_M28	ERMP1 QPCT	2.72e-03	12	123	2	IPR007484
Domain	-	A2M C5	2.72e-03	12	123	2	1.50.10.20
Domain	Mit_uncoupling	SLC25A4 SLC25A6	2.72e-03	12	123	2	IPR002030
Domain	Galactose-bd-like	PCSK5 LAMC1 PCSK6 CNTNAP4	3.46e-03	94	123	4	IPR008979
Domain	PLAC	PCSK5 PCSK6	3.72e-03	14	123	2	PF08686
Domain	Growth_fac_rcpt_	PCSK5 ATRN LAMC1 PCSK6 C8A	3.74e-03	156	123	5	IPR009030
Domain	-	COL8A1 C1QB C1QTNF4	4.36e-03	50	123	3	2.60.120.40
Domain	TPR_2	TTC28 TTC9B TTC9	4.36e-03	50	123	3	PF07719
Domain	TPR_2	TTC28 TTC9B TTC9	4.36e-03	50	123	3	IPR013105
Domain	EGF	PCSK5 ATRN LAMC1 FAT2 PCSK6 CNTNAP4	4.66e-03	235	123	6	SM00181
Domain	Integrin_alpha_C_CS	ITGA2 ITGA9	4.86e-03	16	123	2	IPR018184
Domain	-	PLXNB2 IQGAP1	4.86e-03	16	123	2	1.10.506.10
Domain	PPIase_FKBP	TTC9B TTC9	5.48e-03	17	123	2	IPR023566
Domain	Propept_inh	PCSK5 PCSK6	5.48e-03	17	123	2	IPR009020
Domain	Integrin_alpha-2	ITGA2 ITGA9	6.14e-03	18	123	2	IPR013649
Domain	Terpenoid_cyclase/PrenylTrfase	A2M C5	6.14e-03	18	123	2	IPR008930
Domain	INTEGRIN_ALPHA	ITGA2 ITGA9	6.14e-03	18	123	2	PS00242
Domain	Integrin_alpha2	ITGA2 ITGA9	6.14e-03	18	123	2	PF08441
Domain	Integrin_alpha	ITGA2 ITGA9	6.14e-03	18	123	2	IPR000413
Domain	RasGAP_dom	PLXNB2 IQGAP1	6.14e-03	18	123	2	IPR001936
Domain	Furin_repeat	PCSK5 PCSK6	6.14e-03	18	123	2	IPR006212
Domain	FU	PCSK5 PCSK6	6.14e-03	18	123	2	SM00261
Pubmed	Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element.	RFX1 RFX2 RFX3	4.76e-08	3	127	3	15024578
Pubmed	Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains.	RFX1 RFX2 RFX3	4.76e-08	3	127	3	10330134
Pubmed	Ciliogenic RFX transcription factors regulate FGF1 gene promoter.	RFX1 RFX2 RFX3	4.76e-08	3	127	3	22415835
Pubmed	Drosophila regulatory factor X is necessary for ciliated sensory neuron differentiation.	RFX1 RFX2 RFX3	4.76e-08	3	127	3	12403718
Pubmed	Interplay of RFX transcription factors 1, 2 and 3 in motile ciliogenesis.	RFX1 RFX2 RFX3	4.76e-08	3	127	3	32725242
Pubmed	RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins.	RFX1 RFX2 RFX3	4.76e-08	3	127	3	8289803
Pubmed	Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members.	RFX1 RFX2 RFX3	1.90e-07	4	127	3	11682486
Pubmed	Differential expression of Rfx1-4 during mouse spermatogenesis.	RFX1 RFX2 RFX3	1.90e-07	4	127	3	19596083
Pubmed	Rfx6 directs islet formation and insulin production in mice and humans.	RFX6 RFX1 RFX2 RFX3	9.67e-07	21	127	4	20148032
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	SEL1L A2M HEXB ATRN SLC25A6 MAT2A LAMC1 FBXW2 PLXNB2 PCYOX1L PTPRC FAF2	2.76e-06	613	127	12	22268729
Pubmed	A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic protein 1 in lymphopoiesis and innate immunity.	SAA1 SAA2 PTPRC	3.93e-06	9	127	3	19015308
Pubmed	Glutamate dehydrogenase in cerebellar mutant mice: gene localization and enzyme activity in different tissues.	GLUD1 GLUD2 AGTPBP1	3.93e-06	9	127	3	2293612
Pubmed	Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants.	SLC25A4 SLC25A6 MAT2A IQGAP1 FAF2 GLUD1 GLUD2 EIF3C	4.87e-06	256	127	8	35777956
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	A2M ATRN LAMC1 JAM2 FAT2 C5 C8A CNTN1	5.01e-06	257	127	8	16335952
Pubmed	High-resolution linkage map of mouse chromosome 13 in the vicinity of the host resistance locus Lgn1.	HEXB HTR1A ITGA2	5.60e-06	10	127	3	9119362
Pubmed	Polymorphisms in the SAA1/2 gene are associated with carotid intima media thickness in healthy Han Chinese subjects: the Cardiovascular Risk Survey.	SAA1 SAA2	1.32e-05	2	127	2	21103356
Pubmed	The rate and significance of type 1/type 2 serum amyloid A protein gene polymorphisms in patients with ankylosing spondylitis and amyloidosis.	SAA1 SAA2	1.32e-05	2	127	2	26300108
Pubmed	DNA sequence evidence for polymorphic forms of human serum amyloid A (SAA).	SAA1 SAA2	1.32e-05	2	127	2	3800865
Pubmed	Glutamate Delta-1 Receptor Regulates Inhibitory Neurotransmission in the Nucleus Accumbens Core and Anxiety-Like Behaviors.	GLUD1 GLUD2	1.32e-05	2	127	2	34173171
Pubmed	Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation.	GLUD1 GLUD2	1.32e-05	2	127	2	28621566
Pubmed	Serum Amyloid A Induces Inflammation, Proliferation and Cell Death in Activated Hepatic Stellate Cells.	SAA1 SAA2	1.32e-05	2	127	2	26937641
Pubmed	GluD1 knockout mice with a pure C57BL/6N background show impaired fear memory, social interaction, and enhanced depressive-like behavior.	GLUD1 GLUD2	1.32e-05	2	127	2	32078638
Pubmed	Development of mice with brain-specific deletion of floxed glud1 (glutamate dehydrogenase 1) using cre recombinase driven by the nestin promoter.	GLUD1 GLUD2	1.32e-05	2	127	2	23595828
Pubmed	Influence of Serum Amyloid A (SAA1) and SAA2 gene polymorphisms on renal amyloidosis, and on SAA/C-reactive protein values in patients with familial mediterranean fever in the Turkish population.	SAA1 SAA2	1.32e-05	2	127	2	15170927
Pubmed	Acute-phase, but not constitutive serum amyloid A (SAA) is chemotactic for cultured human aortic smooth muscle cells.	SAA1 SAA2	1.32e-05	2	127	2	12557751
Pubmed	Serum amyloid alpha 1-2 are not required for liver inflammation in the 4T1 murine breast cancer model.	SAA1 SAA2	1.32e-05	2	127	2	36817472
Pubmed	Association of genetic variation in serum amyloid-A with cardiovascular disease and interactions with IL6, IL1RN, IL1beta and TNF genes in the Cardiovascular Health Study.	SAA1 SAA2	1.32e-05	2	127	2	19729864
Pubmed	Interaction between glutamate dehydrogenase (GDH) and L-leucine catabolic enzymes: intersecting metabolic pathways.	GLUD1 GLUD2	1.32e-05	2	127	2	21621574
Pubmed	Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression.	MAT1A MAT2A	1.32e-05	2	127	2	22318685
Pubmed	Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia.	GLUD1 GLUD2	1.32e-05	2	127	2	28911206
Pubmed	No evidence for a role of adipose tissue-derived serum amyloid a in the development of insulin resistance or obesity-related inflammation in hSAA1(+/-) transgenic mice.	SAA1 SAA2	1.32e-05	2	127	2	23967285
Pubmed	Diversity and complexity of the mouse Saa1 and Saa2 genes.	SAA1 SAA2	1.32e-05	2	127	2	24521869
Pubmed	Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase.	GLUD1 GLUD2	1.32e-05	2	127	2	22875990
Pubmed	Molecular basis of human glutamate dehydrogenase regulation under changing energy demands.	GLUD1 GLUD2	1.32e-05	2	127	2	15578726
Pubmed	Heterogeneity of human serum amyloid A protein. Five different variants from one individual demonstrated by cDNA sequence analysis.	SAA1 SAA2	1.32e-05	2	127	2	1971508
Pubmed	Important role of Ser443 in different thermal stability of human glutamate dehydrogenase isozymes.	GLUD1 GLUD2	1.32e-05	2	127	2	15044002
Pubmed	Serum amyloid A induces calcium mobilization and chemotaxis of human monocytes by activating a pertussis toxin-sensitive signaling pathway.	SAA1 SAA2	1.32e-05	2	127	2	7561109
Pubmed	Induction of excitatory and inhibitory presynaptic differentiation by GluD1.	GLUD1 GLUD2	1.32e-05	2	127	2	22138648
Pubmed	Human serum amyloid A. Three hepatic mRNAs and the corresponding proteins in one person.	SAA1 SAA2	1.32e-05	2	127	2	3183061
Pubmed	Glutamate Dehydrogenase Is Important for Ammonia Fixation and Amino Acid Homeostasis in Brain During Hyperammonemia.	GLUD1 GLUD2	1.32e-05	2	127	2	34220417
Pubmed	Complete primary structures of two major murine serum amyloid A proteins deduced from cDNA sequences.	SAA1 SAA2	1.32e-05	2	127	2	3857624
Pubmed	Expression of human GLUD1 and GLUD2 glutamate dehydrogenases in steroid producing tissues.	GLUD1 GLUD2	1.32e-05	2	127	2	26241911
Pubmed	Differential levels of glutamate dehydrogenase 1 (GLUD1) in Balb/c and C57BL/6 mice and the effects of overexpression of the Glud1 gene on glutamate release in striatum.	GLUD1 GLUD2	1.32e-05	2	127	2	21446915
Pubmed	A novel mechanism of the M1-M2 methionine adenosyltransferase switch-mediated hepatocellular carcinoma metastasis.	MAT1A MAT2A	1.32e-05	2	127	2	29749642
Pubmed	Serum amyloid A protein induces production of matrix metalloproteinases by human synovial fibroblasts.	SAA1 SAA2	1.32e-05	2	127	2	9605178
Pubmed	GluD1 binds GABA and controls inhibitory plasticity.	GLUD1 GLUD2	1.32e-05	2	127	2	38060673
Pubmed	Gene expression patterns in the hippocampus during the development and aging of Glud1 (Glutamate Dehydrogenase 1) transgenic and wild type mice.	GLUD1 GLUD2	1.32e-05	2	127	2	24593767
Pubmed	Potentiation of neuronal activity by tonic GluD1 current in brain slices.	GLUD1 GLUD2	1.32e-05	2	127	2	37154294
Pubmed	Serum amyloid A is a soluble pattern recognition receptor that drives type 2 immunity.	SAA1 SAA2	1.32e-05	2	127	2	32572240
Pubmed	Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission.	GLUD1 GLUD2	1.32e-05	2	127	2	22924626
Pubmed	Effect of serum amyloid A on selected in vitro functions of isolated human neutrophils.	SAA1 SAA2	1.32e-05	2	127	2	9823935
Pubmed	AA amyloidosis-resistant CE/J mice have Saa1 and Saa2 genes that encode an identical SAA isoform.	SAA1 SAA2	1.32e-05	2	127	2	24228751
Pubmed	The frequencies of the serum amyloid A2 alleles in healthy (Turkish, Azerbaijan and Kazakh) populations.	SAA1 SAA2	1.32e-05	2	127	2	16152805
Pubmed	Differential glucocorticoid enhancement of the cytokine-driven transcriptional activation of the human acute phase serum amyloid A genes, SAA1 and SAA2.	SAA1 SAA2	1.32e-05	2	127	2	12077270
Pubmed	RFX1 and RFX3 Transcription Factors Interact with the D Sequence of Adeno-Associated Virus Inverted Terminal Repeat and Regulate AAV Transduction.	RFX1 RFX3	1.32e-05	2	127	2	29317724
Pubmed	Regulation of the human acute phase serum amyloid A genes by tumour necrosis factor-alpha, interleukin-6 and glucocorticoids in hepatic and epithelial cell lines.	SAA1 SAA2	1.32e-05	2	127	2	14871291
Pubmed	Nerve tissue-specific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: implications for biologic function.	GLUD1 GLUD2	1.32e-05	2	127	2	11032875
Pubmed	Alterations of Methionine Metabolism as Potential Targets for the Prevention and Therapy of Hepatocellular Carcinoma.	MAT1A MAT2A	1.32e-05	2	127	2	31234428
Pubmed	Isolation and purification of two major serum amyloid A isotypes SAA1 and SAA2 from the acute phase plasma of mice.	SAA1 SAA2	1.32e-05	2	127	2	9518179
Pubmed	Histological expression of methionine adenosyl transferase (MAT) 2A as a post-surgical prognostic surrogate in patients with hepatocellular carcinoma.	MAT1A MAT2A	1.32e-05	2	127	2	29448301
Pubmed	Localization of Human Glutamate Dehydrogenases Provides Insights into Their Metabolic Role and Their Involvement in Disease Processes.	GLUD1 GLUD2	1.32e-05	2	127	2	29943084
Pubmed	A novel D104G mutation in the adenine nucleotide translocator 1 gene in autosomal dominant progressive external ophthalmoplegia patients with mitochondrial DNA with multiple deletions.	SLC25A4 SLC25A6	1.32e-05	2	127	2	12112115
Pubmed	Structural prerequisites for serum amyloid A fibril formation.	SAA1 SAA2	1.32e-05	2	127	2	8376413
Pubmed	Glutamate dehydrogenase deficiency disrupts glutamate homeostasis in hippocampus and prefrontal cortex and impairs recognition memory.	GLUD1 GLUD2	1.32e-05	2	127	2	31898404
Pubmed	Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux.	GLUD1 GLUD2	1.32e-05	2	127	2	15378063
Pubmed	Cutting Edge: IL-1R1 Mediates Host Resistance to Mycobacterium tuberculosis by Trans-Protection of Infected Cells.	PTPRC IL1R1	1.32e-05	2	127	2	30068597
Pubmed	Widening Spectrum of Cellular and Subcellular Expression of Human GLUD1 and GLUD2 Glutamate Dehydrogenases Suggests Novel Functions.	GLUD1 GLUD2	1.32e-05	2	127	2	27422263
Pubmed	Role of adenine nucleotide translocator 1 in mtDNA maintenance.	SLC25A4 SLC25A6	1.32e-05	2	127	2	10926541
Pubmed	Critical role of the cysteine 323 residue in the catalytic activity of human glutamate dehydrogenase isozymes.	GLUD1 GLUD2	1.32e-05	2	127	2	15750346
Pubmed	Identification of a region within SEL1L protein required for tumour growth inhibition.	SEL1L SEL1L2	1.32e-05	2	127	2	14729273
Pubmed	Molecular cloning, structure and expression analysis of a full-length mouse brain glutamate dehydrogenase cDNA.	GLUD1 GLUD2	1.32e-05	2	127	2	1711373
Pubmed	Serum Amyloid A Promotes Inflammation-Associated Damage and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer.	SAA1 SAA2	1.32e-05	2	127	2	34217896
Pubmed	Serum amyloid A, an acute phase protein, inhibits platelet activation.	SAA1 SAA2	1.32e-05	2	127	2	1697614
Pubmed	Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate.	GLUD1 GLUD2	1.32e-05	2	127	2	20529287
Pubmed	Serum amyloid A facilitates the binding of high-density lipoprotein from mice injected with lipopolysaccharide to vascular proteoglycans.	SAA1 SAA2	1.32e-05	2	127	2	21474830
Pubmed	Determination of glutamate dehydrogenase activity and its kinetics in mouse tissues using metabolic mapping (quantitative enzyme histochemistry).	GLUD1 GLUD2	1.32e-05	2	127	2	25124006
Pubmed	Structure of a human serum amyloid A gene and modulation of its expression in transfected L cells.	SAA1 SAA2	1.32e-05	2	127	2	2890635
Pubmed	Unexpected histone H3 tail-clipping activity of glutamate dehydrogenase.	GLUD1 GLUD2	1.32e-05	2	127	2	23673664
Pubmed	Cell-surface processing of extracellular human immunodeficiency virus type 1 Vpr by proprotein convertases.	PCSK5 PCSK6	1.32e-05	2	127	2	18061232
Pubmed	Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complications.	SAA1 SAA2	1.32e-05	2	127	2	16737350
Pubmed	Lack of evidence for direct ligand-gated ion channel activity of GluD receptors.	GLUD1 GLUD2	1.32e-05	2	127	2	39052831
Pubmed	Murine apolipoprotein serum amyloid A in solution forms a hexamer containing a central channel.	SAA1 SAA2	1.32e-05	2	127	2	12456883
Pubmed	The Impairment of Macrophage-to-Feces Reverse Cholesterol Transport during Inflammation Does Not Depend on Serum Amyloid A.	SAA1 SAA2	1.32e-05	2	127	2	23431457
Pubmed	Metabolism changes during aging in the hippocampus and striatum of glud1 (glutamate dehydrogenase 1) transgenic mice.	GLUD1 GLUD2	1.32e-05	2	127	2	24442550
Pubmed	The Amplifying Pathway of the β-Cell Contributes to Diet-induced Obesity.	GLUD1 GLUD2	1.32e-05	2	127	2	27137930
Pubmed	Large-scale isotype-specific quantification of Serum amyloid A 1/2 by multiple reaction monitoring in crude sera.	SAA1 SAA2	1.32e-05	2	127	2	22300576
Pubmed	Extracellular matrix-anchored serum amyloid A preferentially induces mast cell adhesion.	SAA1 SAA2	1.32e-05	2	127	2	9252455
Pubmed	GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution.	GLUD1 GLUD2	1.32e-05	2	127	2	26440896
Pubmed	Inflammatory remodeling of the HDL proteome impairs cholesterol efflux capacity.	SAA1 SAA2	1.32e-05	2	127	2	25995210
Pubmed	Study of structure-function relationships in human glutamate dehydrogenases reveals novel molecular mechanisms for the regulation of the nerve tissue-specific (GLUD2) isoenzyme.	GLUD1 GLUD2	1.32e-05	2	127	2	12742085
Pubmed	Linkage of protection against amyloid fibril formation in the mouse to a single, autosomal dominant gene.	SAA1 SAA2	1.32e-05	2	127	2	7760010
Pubmed	Serum amyloid A exhibits pH dependent antibacterial action and contributes to host defense against Staphylococcus aureus cutaneous infection.	SAA1 SAA2	1.32e-05	2	127	2	31819008
Pubmed	SAA does not induce cytokine production in physiological conditions.	SAA1 SAA2	1.32e-05	2	127	2	23165195
Pubmed	S-adenosyl-L-methionine modifies antioxidant-enzymes, glutathione-biosynthesis and methionine adenosyltransferases-1/2 in hepatitis C virus-expressing cells.	MAT1A MAT2A	1.32e-05	2	127	2	27076759
Pubmed	The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19.	RFX1 RFX2	1.32e-05	2	127	2	1505960
Pubmed	A seven-transmembrane, G protein-coupled receptor, FPRL1, mediates the chemotactic activity of serum amyloid A for human phagocytic cells.	SAA1 SAA2	1.32e-05	2	127	2	9892621
Pubmed	Identification of an isoform with an extremely large Cys-rich region of PC6, a Kex2-like processing endoprotease.	PCSK5 PCSK6	1.32e-05	2	127	2	8335106
Pubmed	Apoptotic and anti-proliferative effects of all-trans retinoic acid. Adenine nucleotide translocase sensitizes HeLa cells to all-trans retinoic acid.	SLC25A4 SLC25A6	1.32e-05	2	127	2	16556444
Pubmed	Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selection.	GLUD1 GLUD2	1.32e-05	2	127	2	18688271
Pubmed	Impact of serum amyloid A on high density lipoprotein composition and levels.	SAA1 SAA2	1.32e-05	2	127	2	20667817
Cytoband	22q13.33	SCO2 CHKB PLXNB2	1.62e-04	38	127	3	22q13.33
GeneFamily	Regulatory factor X family	RFX6 RFX1 RFX2 RFX3	2.58e-08	8	81	4	1153
GeneFamily	Complement system\|Sushi domain containing	C1QB C5 C8A	5.56e-04	36	81	3	492
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	A2M C5	6.99e-04	9	81	2	1234
GeneFamily	Proprotein convertase subtilisin/kexin family	PCSK5 PCSK6	6.99e-04	9	81	2	973
GeneFamily	CD molecules\|Integrin alpha subunits	ITGA2 ITGA9	2.90e-03	18	81	2	1160
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	SEL1L A2M IQGAP1 ANKRD44 PTPRC NKTR SPEN AGTPBP1	7.93e-08	191	127	8	9454f642c3621370fa23640b631301346b300950
ToppCell	10x5'-bone_marrow-Myeloid_Mac-Intestinal_macrophages\|bone_marrow / Manually curated celltypes from each tissue	A2M TTC28 OLFML2B ITGA9 GLUD2 C1QB RBM47	6.93e-07	174	127	7	0746344d62aa7ab77c378e9d5a9f9238e741a76b
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	SEL1L A2M ERMP1 ANKRD44 PTPRC SPEN AGTPBP1	1.05e-06	185	127	7	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	SEL1L A2M ERMP1 ANKRD44 PTPRC SPEN AGTPBP1	1.08e-06	186	127	7	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	critical-Epithelial\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ITGA2 PLXNB2 SAA1 SAA2 PLPP2 TJP2 TTC9	1.70e-06	199	127	7	bbb44e2a52f102a6d891ead6c06d6c07221abd33
ToppCell	NS-critical-d_07-13-Epithelial\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ITGA2 PLXNB2 SAA1 SAA2 PLPP2 TJP2 TTC9	1.70e-06	199	127	7	b88a81cd2a89f4d27100c96ae4324dcee68daf83
ToppCell	droplet-Liver-Hepatocytes-24m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAT1A SLCO1B3 SAA1 EFNA1 ETNK2 C8A	4.79e-06	151	127	6	e243b6c76e59035f10519a86399b598dd2123f87
ToppCell	droplet-Liver-Hepatocytes-24m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAT1A SLCO1B3 SAA1 EFNA1 ETNK2 C8A	4.79e-06	151	127	6	cdd2ce0969da446616627e3569bbe5a5d9b475bd
ToppCell	facs-Marrow-T_cells-18m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NOL4 SLCO1B3 ALPK1 RFX2 SAA1 SAA2	9.12e-06	169	127	6	2a35846b0e0be0a19a5a04a86cbd72ce65257c8a
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TRMT11 SAA1 SAA2 PTCD2 C5 TRIM16L	1.08e-05	174	127	6	e2243f1e48e3275753a2b3a69d06eefce69a8ded
ToppCell	COVID-19-kidney-PCT-S3-2\|kidney / Disease (COVID-19 only), tissue and cell type	MAT1A SLCO1B3 SAA1 PCSK6 C5 C8A	1.08e-05	174	127	6	5aa2fb631505600f37d2b87b02def7be139dc262
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NOL4 RFX6 HOXA13 FGF20 MANEAL QPCT	1.27e-05	179	127	6	d70791d2a0db35a6b013fa7ed2f9f39364581eff
ToppCell	10x5'-lymph-node_spleen-Myeloid_Mac-Intestinal_macrophages\|lymph-node_spleen / Manually curated celltypes from each tissue	A2M OLFML2B ITGA9 PLXNB2 C1QB RBM47	1.31e-05	180	127	6	7be7d7a6906fff6dbdecd9cb013d855aba4eda2a
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2M WSCD1 ITGA2 JAM2 EFNA1 PLPP2	1.39e-05	182	127	6	0346f81bbb1f309f3e9d063b20547d548d09472c
ToppCell	AT2_cells-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	COL8A1 SLC25A4 CHKB EFNA1 C5 CNTN1	1.53e-05	185	127	6	3b3268e3f99121124e33086cac88479808d31630
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	A2M PCSK5 TTC28 ITGA9 JAM2 CNTNAP4	1.88e-05	192	127	6	56b021c297a21dff357531f21e2464f85186106d
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2M WSCD1 ITGA2 JAM2 EFNA1 PLPP2	2.11e-05	196	127	6	ae46d4b00be92e64e46252dcc156161b171eded4
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Lhx6\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ITGA9 JAM2 CDCA7 QPCT IL1R1	2.15e-05	117	127	5	0602bbad908cb28c5093b74d717da5f2af577943
ToppCell	Bronchus_Control_(B.)\|World / Sample group, Lineage and Cell type	NBEA ITGA2 SAA1 SAA2 TMEM184A PLPP2	2.17e-05	197	127	6	b6dff2ee108813e18657e2d8cf850e2423f8c8e9
ToppCell	Healthy_donor\|World / disease group, cell group and cell class (v2)	SLC25A6 HLA-F ANKRD44 PTPN4 PTPRC NKTR	2.24e-05	198	127	6	1ed0b50c9754727a05c27b21f3546bf2e37eef7f
ToppCell	NS-critical-d_16-33-Epithelial\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ITGA2 PLXNB2 SAA1 SAA2 PLPP2 TJP2	2.30e-05	199	127	6	3b68197ec01c5f2b315d9e9b6eb02d5f6b5b77a3
ToppCell	NS-moderate-d_16-33-Epithelial\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PLXNB2 SAA1 SAA2 PLPP2 TJP2 TTC9	2.30e-05	199	127	6	aa2b51940115c22768c0d7493b4b60d41df3f376
ToppCell	moderate-Epithelial\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	PLXNB2 SAA1 SAA2 PLPP2 TJP2 TTC9	2.37e-05	200	127	6	095783c9b75113ae350c2d5fb1195d71b41fa695
ToppCell	background-Hepatocytes\|background / Sample and Cell Type and Tumor Cluster (all cells)	A2M MAT1A PCSK6 GLUD1 C5 C8A	2.37e-05	200	127	6	787d35b5c2f2ad967ae14e99496a0299ac7e72fd
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_airway_basal-Suprabasal\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ITGA2 SAA2 FAT2 TMEM184A PLPP2 TRPV4	2.37e-05	200	127	6	924eacea513dde8e3bd805a335bc4285647b800d
ToppCell	COVID-19-COVID-19_Mild\|COVID-19 / Disease, condition lineage and cell class	HLA-F PLXNB2 ANKRD44 ZBTB7A PTPRC NKTR	2.37e-05	200	127	6	62c25042086f1afd1102e0720e933c2e476468fd
ToppCell	droplet-Liver-Hepatocytes-24m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAT1A SLCO1B3 SAA1 EFNA1 C8A	6.01e-05	145	127	5	f142b86d4da5b71c189da46cbc4beebdc387ffee
ToppCell	droplet-Liver-Hepatocytes-24m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAT1A SLCO1B3 SAA1 EFNA1 C8A	7.52e-05	152	127	5	c21e2152b0130485659051d8fb7fb4589d1ec997
ToppCell	droplet-Liver-Hepatocytes-24m-Epithelial-Hepatocyte_(Pericentral_and_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAT1A SLCO1B3 EFNA1 ETNK2 C8A	8.00e-05	154	127	5	a5289000597068ee8d559f89bce7bce31f35dd57
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c13-HAVCR2\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	AGGF1 NBEA CDCA7 ETNK2 ZNF700	9.02e-05	158	127	5	a38345ffc5a7576ce99212bcbd620864a19de1fc
ToppCell	RSV-Healthy-6\|Healthy / Virus stimulation, Condition and Cluster	PCNX3 GXYLT1 ERMP1 MANEAL MYO3B	1.08e-04	164	127	5	1b9c5a6dc4e09b90f92e98b81a5ee620f8479cc7
ToppCell	RSV-Healthy-6\|RSV / Virus stimulation, Condition and Cluster	PCNX3 GXYLT1 ERMP1 MANEAL MYO3B	1.08e-04	164	127	5	ab312b8c2f828ea7331f2a340c4df81587a23b5c
ToppCell	facs-Marrow-Granulocytes-24m-Hematologic-hematopoietic_stem_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEXB PLXNB2 EFNA1 C1QB VSIG8	1.27e-04	170	127	5	8d3c51364a332020810836e2055c60893c10d7f3
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PCSK5 TENT4B USP2 PTPN4 AP3S2	1.38e-04	173	127	5	4968712af1cca8c932abd3323631d7dcaffd4a66
ToppCell	droplet-Liver-Npc-18m-Myeloid-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PIGN PCDHB14 IQGAP1 PTPRC C1QB	1.38e-04	173	127	5	9ba55e21d1037ec3150d77895e52f0b051df65da
ToppCell	Mesenchymal_cells-Osteo-CAR\|Mesenchymal_cells / Lineage and Cell class	A2M COL8A1 OLFML2B MIPEP DLX5	1.42e-04	174	127	5	430e3cd61bc2a471959faa40e817aa4dd7d82d28
ToppCell	PCW_05-06-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	WSCD1 NOL4 RFX6 TMEM184A QPCT	1.46e-04	175	127	5	9941c35601134d88d1b3249c81f8b43a8fc61610
ToppCell	(03)_Secretory-(4)_1wkpi\|(03)_Secretory / shred by cell type and Timepoint	SEL1L HEXB USP2 ZBTB7A CNTN1	1.46e-04	175	127	5	06b52f85baa31b55bb31477244892b6da79fe2c9
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_D3\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	NBEA ALPK1 PCYOX1L ETNK2 QPCT	1.50e-04	176	127	5	bd5c85b3a4fb88ffe156599f6d224aa7664a513a
ToppCell	COVID-19-kidney-PCT-S3-2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MAT1A SLCO1B3 SAA1 C5 C8A	1.50e-04	176	127	5	b6497324e3e52f514ce556a3fa0c3011c45dcc7b
ToppCell	10x5'v1-week_12-13-Lymphocytic_B-B_lineage-naive_B_cell\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	MAT1A SIPA1L3 HLA-F ANKRD44 PTPRC	1.54e-04	177	127	5	325c10674b18727ddd50bf088a9c6f4ef29aa809
ToppCell	lung\|World / shred on tissue and cell subclass	A2M IQGAP1 C5 IL1R1 CNTN1	1.58e-04	178	127	5	7b1e371272328d6b6c3994382d64281ffc737db2
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(NPW+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NOL4 RFX6 HOXA13 MANEAL QPCT	1.70e-04	181	127	5	2392af8c7f040c23a7d416c2e37419954970c8f4
ToppCell	10x5'-bone_marrow-Myeloid_Mac-Macrophage\|bone_marrow / Manually curated celltypes from each tissue	OLFML2B RFX2 TJP2 C1QB RBM47	1.70e-04	181	127	5	d2aa5b53162fb5c4cbbedbd2cb4b2b614e8c4afa
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_MHC-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	A2M MAT2A SIPA1 C1QB TRPV4	1.75e-04	182	127	5	16186b7a0c33caa48631962381e3ab7e5d166163
ToppCell	Adult-Epithelial-basal_cell\|Adult / Lineage, Cell type, age group and donor	ITGA2 ITGA9 FAT2 PLPP2 TRPV4	1.79e-04	183	127	5	00a6b19ca49e3b8e0d1cd387a3515b0ff4b81c81
ToppCell	PCW_05-06-Neuronal-Neuronal_postreplicative-neuro_immature_neuronal_(2)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	MYT1L NOL4 TTC9B MANEAL DLX5	1.79e-04	183	127	5	9dfb398b9995d562864fe688861a831ada0814cd
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-NPC-like-NPC-like_neural-D\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MYT1L SLC25A6 CDCA7 DLX5 EIF3C	1.79e-04	183	127	5	0e468daed40c28dca64a9bc2867b46e4ea9d1a06
ToppCell	Control-Neu_4\|World / 5 Neutrophil clusters in COVID-19 patients	AGGF1 SPART NPLOC4 EIF3C IL1R1	1.84e-04	184	127	5	ce7f044956613118ee2e9fb6af2455c3166cb414
ToppCell	PCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	RFX6 ITGA2 FGF20 C5 RBM47	1.84e-04	184	127	5	fa4915b0498f3069fd5ef497286445528f75187e
ToppCell	PBMC-Mild-cDC_9\|Mild / Compartment, Disease Groups and Clusters	PIGN SCO2 JAM2 TJP2 C1QB	1.84e-04	184	127	5	2e0c9a2c40c892a2d435eafb31f1f838de9baf15
ToppCell	PND07-28-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_C\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	PCSK5 OLFML2B ITGA9 QPCT TJP2	1.89e-04	185	127	5	427176ad9ab8d9511200fb0a132cfd1e835fe35c
ToppCell	droplet-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l20-1\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	OLFML2B LAMC1 USP2 PCSK6 QPCT	1.89e-04	185	127	5	d5f5866924648a3c14e2596218fd548a31777aa3
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ACSS1 USP2 PTPN4 MYO3B RBM47	1.93e-04	186	127	5	4dafc215c42e7949f932a3627359c107943b5d6b
ToppCell	10x3'2.3-week_17-19-Endothelial-stroma-proliferating_EC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	A2M TTC28 LAMC1 JAM2 EFNA1	1.93e-04	186	127	5	a844d4f79e0ad5d6c60a4488ffd8f4f21b7eed04
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-hematologic\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MAT1A SLCO1B3 SAA1 SAA2 C8A	1.98e-04	187	127	5	edb0ab0154542b1c0b3a2c216c4a60f0f06290b3
ToppCell	droplet-Bladder-BLADDER-1m-Epithelial-bladder_urothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATRN ERMP1 FAT2 TRPV4 RBM47	1.98e-04	187	127	5	aa336fb568a24e12c0454265ddd71ed10a6614cf
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL8A1 ACSS1 USP2 MYO3B CNTN1	1.98e-04	187	127	5	7ea8731288e2a99f45e3958590ee1d76f49ae888
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_anti-infl-B\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SLC25A6 TRIM34 RFX6 C1QB EIF3C	2.03e-04	188	127	5	a9705f24e37b4aad8e42c9bf5bc1b9be2d01e761
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	RFX6 ITGA2 FGF20 C5 RBM47	2.08e-04	189	127	5	5d9da836ce4308b8458bb3be3871a0aca734b6cd
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	OLFML2B ITGA9 ANKRD44 PTPRC C1QB	2.08e-04	189	127	5	7ccea2df93bb4b37417bbc8f6c85a61ece95211a
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51\|PBMC_fresh-frozen / Compartment, severity and other cell annotations on 10x 3' data (130k)	A2M HLA-F ANKRD44 PTPN4 NKTR	2.08e-04	189	127	5	0e8d1be3c406d1a393e18faccfe89116a8f82bcf
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	JAM2 CDCA7 CNTNAP4 DLX5 IL1R1	2.08e-04	189	127	5	979b7fa947538aa7ca4a219263da2575869a2caa
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M PCSK5 TTC28 JAM2 AGTPBP1	2.08e-04	189	127	5	6463890d8dbee4bc198f91628a5f784970de786a
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-hematologic-erythrocytic\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MAT1A SLCO1B3 SAA1 SAA2 C8A	2.08e-04	189	127	5	7899af78b273d9c7f029d52f7e0cf6df4da41f5e
ToppCell	3'_v3-blood-Lymphocytic_T_CD8\|blood / Manually curated celltypes from each tissue	A2M HLA-F ANKRD44 PTPRC DSEL	2.14e-04	190	127	5	5dca8654964c41580fa3b094579fe7cb296d406f
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-hematologic-erythrocytic-erythrocyte\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MAT1A SLCO1B3 SAA1 SAA2 C8A	2.14e-04	190	127	5	a34293601aefe5fb5c400c14091294b9ddaa195b
ToppCell	droplet-Lung-1m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	COL8A1 BCO1 JAM2 TRPV4 RSPH9	2.14e-04	190	127	5	3b9abc25b17e7295356ded57ff2ca519fa9f2686
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell-Goblet_(bronchial)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NBEA SAA1 SAA2 TMEM184A PLPP2	2.14e-04	190	127	5	23f2ac4da431211084bb6ab0494c2e0b69547cb6
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-bronchial_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NBEA SAA1 SAA2 TMEM184A PLPP2	2.14e-04	190	127	5	3c337374d89e69cc0a78e65a4a7e21db7b050fcd
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_INF-C\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SLC25A6 OLFML2B TRIM34 C1QB ZNF80	2.19e-04	191	127	5	b2759c1ce3793a0913d49b91576a9ab641dfea8f
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Degenerative_Medullary_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC25A4 SLC25A6 ACSS1 USP2 MYO3B	2.19e-04	191	127	5	f631749ef1f2270133664cf5eb4cf545a8482bd3
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	A2M PCSK5 COL8A1 ITGA9 JAM2	2.19e-04	191	127	5	b2c86cde341fe350143658c8a8a4a9edbce3f19b
ToppCell	356C-Epithelial_cells-Epithelial-F_(Ciliated)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	SAA1 SAA2 PLPP2 DNAI4 RSPH9	2.19e-04	191	127	5	dad675251e129254955eac179c84a641a4864586
ToppCell	356C-Epithelial_cells-Epithelial-F_(Ciliated)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	SAA1 SAA2 PLPP2 DNAI4 RSPH9	2.19e-04	191	127	5	6d2cf41ee946137c039ddcc13593fc3f670afbba
ToppCell	PCW_13-14-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	NOL4 EFNA1 PLPP2 MYO3B RBM47	2.19e-04	191	127	5	63aa671837b79d2feb7ed1e67712cc01caf72bef
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	A2M WSCD1 ITGA2 JAM2 EFNA1	2.24e-04	192	127	5	5a0615fdc217554ccd611504b16e5d97628e207d
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-3.5_mon-Neuronal-CFuPNs\|3.5_mon / Sample Type, Dataset, Time_group, and Cell type.	PCSK5 SLC25A4 TTC9B NBEA CNTN1	2.24e-04	192	127	5	a8841ebd879f1c344ab4246fdef77044170f644d
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	JAM2 CDCA7 CNTNAP4 DLX5 IL1R1	2.24e-04	192	127	5	bd3fa6c8fcb618db64d11f25cabaf08608957c35
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	A2M HLA-F PTPN4 PTPRC DSEL	2.24e-04	192	127	5	ab88ea7723f0fa3b39611981c043445f27425404
ToppCell	15-Trachea-Epithelial-Intermediate_ciliated\|Trachea / Age, Tissue, Lineage and Cell class	NBEA RFX2 RFX3 TMEM184A DNAI4	2.24e-04	192	127	5	9cbe961a800c981cdc742a47ed18e9c8eb6430bd
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RFX3 SAA1 SAA2 DNAI4 RSPH9	2.30e-04	193	127	5	e1b76102f812c433195d1e8811fdd3293a7bc22e
ToppCell	IIH-CD8\|IIH / Condition, Cell_class and T cell subcluster	HLA-F PTPN4 PTPRC CDCA7 ZNF80	2.30e-04	193	127	5	343ac8c6dc6d7c7a944a14de65f1d4ea3dfafe86
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NBEA ITGA9 BCO1 SAA1 SAA2	2.30e-04	193	127	5	2483bb7f398e4fa0ef09c8bd584ed25703853f03
ToppCell	LA\|World / Chamber and Cluster_Paper	PCSK5 COL8A1 LAMC1 SAA1 PCSK6	2.30e-04	193	127	5	d4bf89437216baf489ea0239136dcedf3b6714af
ToppCell	IIH-CD8-CD8_1\|IIH / Condition, Cell_class and T cell subcluster	HLA-F PTPN4 PTPRC CDCA7 ZNF80	2.30e-04	193	127	5	c5a4926003906d6726155f19061b73fb45d9962c
ToppCell	facs-Bladder-nan-3m-Epithelial-bladder_urothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATRN ERMP1 TJP2 TRPV4 RBM47	2.35e-04	194	127	5	1531dcace28a14bd700e909a027426a8cee20337
ToppCell	critical-Epithelial-Ciliated-diff\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	SAA1 SAA2 C1QB DNAI4 RSPH9	2.35e-04	194	127	5	176090949b53c043c58df63ad8cf4f486b350bdc
ToppCell	Smart-start-Cell-Wel_seq-Neoplastic-Stem-like-NPC-like-NPC-like_neural-E\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	MYT1L AKNAD1 CDCA7 ETNK2 DLX5	2.35e-04	194	127	5	b111d10c99d7ff7eb261cd7786cd9d9a549049b1
ToppCell	LA-02._Fibroblast_II\|LA / Chamber and Cluster_Paper	PCSK5 COL8A1 TTC28 LAMC1 PCSK6	2.35e-04	194	127	5	234d1494c114cce77c619708bbcd8d5ce805f19b
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical\|TCGA-Thryoid / Sample_Type by Project: Shred V9	COL8A1 ITGA2 PLXNB2 TMEM184A QPCT	2.35e-04	194	127	5	b46c54802b8d1e0a0a17f9ed8e82eaf5e7f4849d
ToppCell	3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RFX3 SAA1 SAA2 DNAI4 RSPH9	2.41e-04	195	127	5	d211a836cf711fdb91b10d512f09d462be937cc5
ToppCell	normal_Lung-Epithelial_cells-Club\|normal_Lung / Location, Cell class and cell subclass	SAA1 SAA2 EFNA1 TMEM184A PLPP2	2.41e-04	195	127	5	b46544ad5af04f4dbc2643637caa3d2d50d922ae
ToppCell	LA-02._Fibroblast_II\|World / Chamber and Cluster_Paper	PCSK5 COL8A1 TTC28 LAMC1 PCSK6	2.41e-04	195	127	5	a78b605b49acd8c9d68716266ca269dafcd910b9
ToppCell	Brain_organoid-organoid_Velasco_nature-3_mon-Neuronal-CFuPNs\|3_mon / Sample Type, Dataset, Time_group, and Cell type.	PCSK5 SLC25A4 TTC9B NBEA CNTN1	2.41e-04	195	127	5	574354ef4bcefeb9856b65d19bb92e2cffe5dc7a
ToppCell	T_cells-GZMK+_T_cells\|T_cells / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	A2M HLA-F IQGAP1 ZBTB7A PTPN4	2.41e-04	195	127	5	003ea7ddec6c1c98d2f6470bb51ebd97450eb936
ToppCell	Mesenchymal_cells-Stromal_fibro.\|World / Lineage and Cell class	LAMC1 JAM2 SAA1 SAA2 QPCT	2.41e-04	195	127	5	69723b06c2a5c2aaf4d10874b11bca7f06822bdc
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTC28 NBEA RFX6 IQGAP1 NKTR	2.41e-04	195	127	5	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	Control_saline-Epithelial_airway-airway_epithelial-Ciliated\|Control_saline / Treatment groups by lineage, cell group, cell type	MAT1A RFX2 USP2 DNAI4 TRPV4	2.41e-04	195	127	5	60067b5359174f0d1a8b5748bfc0690762e9e740
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTC28 NBEA RFX6 IQGAP1 NKTR	2.41e-04	195	127	5	7796ea9247f4c63762f0de8490fed08b9717fa23
Drug	oleoylcarnitine	SLC25A4 SLC25A6 CHKB GLUD1 GLUD2	1.92e-08	16	125	5	CID006441392
Drug	silver nitrate	MAT2A LAMC1 SAA1 SAA2 GLUD1 GLUD2	2.80e-07	49	125	6	CID000024470
Drug	isosteviol lactone	LCT GLUD1 GLUD2	1.60e-06	5	125	3	CID000401559
Drug	AC1L1B5W	ITGA2 GLUD1 GLUD2	5.56e-06	7	125	3	CID000001296
Drug	Etiocobalamin	DHX16 A2M SAA1 SAA2 PCSK6 C1QB C5 C8A	6.18e-06	177	125	8	CID006450878
Drug	AC1L1GWH	LCT GLUD1 GLUD2	1.32e-05	9	125	3	CID000003872
Drug	AC1L193Y	SLC25A4 SLC25A6 CHKB GLUD1 GLUD2	2.92e-05	65	125	5	CID000000380
Drug	phenyltriethoxysilane	GLUD1 GLUD2	2.99e-05	2	125	2	CID000013075
Drug	chloropyrimidine	HTR1A ITGA2	2.99e-05	2	125	2	CID000074404
Drug	A31-1-1	MAT1A ITGA2	2.99e-05	2	125	2	CID000016263
Drug	G-3SH	GLUD1 GLUD2	2.99e-05	2	125	2	CID000174237
Drug	iodoacetyldiethylstilbestrol	GLUD1 GLUD2	2.99e-05	2	125	2	CID006455327
Drug	bromo-PADAP	ITGA2 QPCT	2.99e-05	2	125	2	CID005373959
Drug	methylmercuric bromide	GLUD1 GLUD2	2.99e-05	2	125	2	CID000068175
Drug	5-methylisophthalate	GLUD1 GLUD2	2.99e-05	2	125	2	CID000068137
Drug	x 1 s	GLUD1 GLUD2	2.99e-05	2	125	2	CID000409694
Drug	2-amino-4-methylthio-3-butenoic acid	MAT1A MAT2A	2.99e-05	2	125	2	ctd:C083253
Drug	D-pyroglutamate	PCSK6 GLUD1 GLUD2 QPCT TRPV4 C5	3.61e-05	112	125	6	CID000000499
Drug	n-propionyl-CoA	SLC25A4 SLC25A6 MAT2A ACSS1 CHKB GLUD1 GLUD2	3.74e-05	166	125	7	CID000001033
Drug	rafoxanide	RFX1 GLUD1 GLUD2	4.44e-05	13	125	3	CID000031475
Drug	Od-T	MAT1A RFX1 SPEN	5.63e-05	14	125	3	CID006102742
Drug	AC1O3F2U	MAT1A MAT2A PRMT3	7.00e-05	15	125	3	CID006326998
Drug	Neostigmine bromide [114-80-7]; Down 200; 13.2uM; PC3; HT_HG-U133A	SEL1L AGGF1 IQGAP1 FAF2 PTCD2 NKTR SPEN	8.22e-05	188	125	7	6735_DN
Drug	R-5	HTR1A GLUD1 GLUD2	8.59e-05	16	125	3	CID011742733
Drug	L-2-amino-4-methylthio-cis-but-3-enoic acid	MAT1A MAT2A	8.94e-05	3	125	2	CID006439623
Drug	benzylphosphate	MAT1A MAT2A	8.94e-05	3	125	2	CID000074359
Drug	lenthionine	GLUD1 GLUD2	8.94e-05	3	125	2	CID000067521
Drug	mildiomycin	GLUD1 GLUD2	8.94e-05	3	125	2	CID000125665
Drug	Clodronate	SLC25A4 SLC25A6	8.94e-05	3	125	2	DB00720
Drug	methoxyethylmercury	GLUD1 GLUD2	8.94e-05	3	125	2	CID000115155
Drug	4-methylumbelliferyl laurate	GLUD1 GLUD2	8.94e-05	3	125	2	CID000600674
Drug	methylmercuric iodide	GLUD1 GLUD2	8.94e-05	3	125	2	CID000067347
Drug	11-hydroxy-10-methylaporphine	HTR1A BCO1	8.94e-05	3	125	2	CID003082625
Drug	Hexetidine [141-94-6]; Down 200; 11.8uM; MCF7; HT_HG-U133A	SIPA1L3 SPART ALPK1 VPS13D PCSK6 PTCD2 IL1R1	9.37e-05	192	125	7	3318_DN
Drug	Vitamin K2 [11032-49-8]; Up 200; 9uM; MCF7; HT_HG-U133A	ITGA9 LCT JAM2 HHAT PCSK6 NKTR MUC2	9.37e-05	192	125	7	4356_UP
Drug	Selegiline hydrochloride [14611-52-0]; Up 200; 17.8uM; MCF7; HT_HG-U133A	A2M COL8A1 NOX3 VPS13D HHAT PCSK6 TTC9	9.68e-05	193	125	7	4146_UP
Drug	Flutamide [13311-84-7]; Down 200; 14.4uM; MCF7; HT_HG-U133A	PIGN SIPA1L3 AGGF1 IQGAP1 ZBTB7A FAF2 NKTR	1.00e-04	194	125	7	4361_DN
Drug	Flavoxate hydrochloride [3717-88-2]; Down 200; 9.4uM; MCF7; HT_HG-U133A	ATRN COL8A1 NOL10 VPS13D HHAT ETNK2 TTC9	1.03e-04	195	125	7	5427_DN
Drug	Gramine [87-52-5]; Up 200; 23uM; PC3; HT_HG-U133A	COL8A1 OLFML2B RFX1 VPS13D PCSK6 TTC9 DLX5	1.07e-04	196	125	7	3999_UP
Drug	Sotalol hydrochloride [959-24-0]; Up 200; 13uM; MCF7; HT_HG-U133A	WSCD1 COL8A1 NOX3 SIPA1 BCO1 PCSK6 TTC9	1.10e-04	197	125	7	4160_UP
Drug	Niflumic acid [4394-00-7]; Down 200; 14.2uM; MCF7; HT_HG-U133A	SIPA1L3 SPART PTCD2 QPCT TTC9 C5 IL1R1	1.14e-04	198	125	7	5490_DN
Drug	Felbinac [5728-52-9]; Down 200; 18.8uM; MCF7; HT_HG-U133A	A2M COL8A1 ALPK1 VPS13D QPCT C1QB DNAI4	1.14e-04	198	125	7	3398_DN
Drug	Tetrahydroxy-1,4-quinone monohydrate [319-89-1]; Up 200; 21uM; MCF7; HT_HG-U133A	COL8A1 SIPA1 RFX2 BCO1 PCSK6 C1QB DNAI4	1.17e-04	199	125	7	3338_UP
Drug	N-ethylmaleimide	A2M HTR1A SLC25A4 SLC25A6 MAT1A MAT2A PTPN4 PLPP2 MYO3B PRMT3 SPEN	1.21e-04	511	125	11	CID000004362
Drug	calcium carbonate	ATRN SCO2 NOX3 ITGA2 ITGA9 LCT FGF20	1.33e-04	203	125	7	CID000010112
Drug	Ritodrine	USP2 SAA1 SAA2 QPCT	1.52e-04	49	125	4	ctd:D012312
Drug	cyclopentadiene	MAT1A ITGA2 C5	1.72e-04	20	125	3	CID000007612
Drug	methyl benzoquate	GLUD1 GLUD2	1.78e-04	4	125	2	CID000026383
Drug	dehydroabietylamine	SLC25A4 SLC25A6	1.78e-04	4	125	2	ctd:C000600819
Drug	pentenoic acid	GLUD1 GLUD2	1.78e-04	4	125	2	CID000012299
Drug	NSC-187732	MAT1A MAT2A	1.78e-04	4	125	2	CID000302526
Drug	alpha-ketoglutaramate	GLUD1 GLUD2	1.78e-04	4	125	2	CID000000048
Drug	cyclotriveratrylene	MAT1A ITGA2	1.78e-04	4	125	2	CID000273730
Drug	ureidoglycine	GLUD1 GLUD2	1.78e-04	4	125	2	CID000439649
Drug	Ivin	GLUD1 GLUD2	1.78e-04	4	125	2	CID000014083
Drug	8-BDB-TADP	GLUD1 GLUD2	1.78e-04	4	125	2	CID000130791
Drug	cadina-3,9-diene	GLUD1 GLUD2	1.78e-04	4	125	2	CID000010657
Drug	AC1L9CUQ	GLUD1 GLUD2	1.78e-04	4	125	2	CID000442451
Drug	vinthionine	MAT1A MAT2A	1.78e-04	4	125	2	CID000055145
Drug	luxabendazole	GLUD1 GLUD2	1.78e-04	4	125	2	CID000072019
Drug	N-butylmaleimide	GLUD1 GLUD2	1.78e-04	4	125	2	CID000239780
Drug	alpha-methylglutamate	GLUD1 GLUD2	1.78e-04	4	125	2	CID000095440
Drug	2b E2	GLUD1 GLUD2	1.78e-04	4	125	2	CID005327076
Drug	seleno-DL-ethionine	MAT1A MAT2A	1.78e-04	4	125	2	CID000145924
Drug	bicyclo(2.2.2)octane	MAT1A ITGA2	1.78e-04	4	125	2	CID000009235
Disease	Antibody Deficiency Syndrome	C1QB C5 C8A	4.83e-05	17	125	3	C0003257
Disease	fascioliasis (biomarker_via_orthology)	GLUD1 GLUD2	5.33e-05	3	125	2	DOID:885 (biomarker_via_orthology)
Disease	autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 2 (implicated_via_orthology)	SLC25A4 SLC25A6	1.06e-04	4	125	2	DOID:0111517 (implicated_via_orthology)
Disease	Immunologic Deficiency Syndromes	C1QB C5 C8A	1.24e-04	23	125	3	C0021051
Disease	hypertrophic cardiomyopathy (implicated_via_orthology)	SCO2 SLC25A4 SLC25A6	2.50e-04	29	125	3	DOID:11984 (implicated_via_orthology)
Disease	serum amyloid A protein measurement	SAA1 SAA2	2.64e-04	6	125	2	EFO_0004728
Disease	childhood absence epilepsy (biomarker_via_orthology)	GLUD1 GLUD2	2.64e-04	6	125	2	DOID:1825 (biomarker_via_orthology)
Disease	Depression, Postpartum	HTR1A TTC9B	3.69e-04	7	125	2	C0221074
Disease	Complement deficiency disease	C1QB C5 C8A	3.69e-04	33	125	3	C0272242
Disease	mitochondrial metabolism disease (implicated_via_orthology)	SCO2 SLC25A4 SLC25A6	4.40e-04	35	125	3	DOID:700 (implicated_via_orthology)
Disease	neurexophilin-1 measurement	PCSK6 C8A	4.90e-04	8	125	2	EFO_0008244
Disease	depressive symptom measurement, response to antidepressant	MYT1L WSCD1 BIVM ANKRD44	5.44e-04	88	125	4	EFO_0007006, GO_0036276
Disease	postcentral gyrus volume measurement	ATRN DLX5	6.29e-04	9	125	2	EFO_0010323
Disease	neuropsychological test	NCAPD3 ACSS1 JAM2 MANEAL DSEL	1.55e-03	197	125	5	EFO_0003926
Disease	hepatic encephalopathy (biomarker_via_orthology)	GLUD1 GLUD2	1.80e-03	15	125	2	DOID:13413 (biomarker_via_orthology)
Disease	lipid metabolism disorder (implicated_via_orthology)	MAT1A MAT2A	1.80e-03	15	125	2	DOID:3146 (implicated_via_orthology)
Disease	unipolar depression, response to selective serotonin reuptake inhibitor, mood disorder	MYT1L DSEL	2.32e-03	17	125	2	EFO_0003761, EFO_0004247, EFO_0005658
Disease	amino acid measurement	PIGN LARP1 ITGA2 PCYOX1L HHAT PCSK6 GLUD1 C5 MUC2	2.44e-03	678	125	9	EFO_0005134
Disease	serum amyloid A-1 protein measurement	SAA1 SAA2	2.61e-03	18	125	2	EFO_0008282
Disease	magnesium measurement	TTC28 ITGA2 ALPK1	2.80e-03	66	125	3	EFO_0004845
Disease	acute lymphoblastic leukemia, response to antineoplastic agent	NOX3 PRMT3	2.90e-03	19	125	2	EFO_0000220, GO_0097327
Disease	anti-Mullerian hormone measurement	TTC28 CDCA7	3.22e-03	20	125	2	EFO_0004769
Disease	respiratory system disease	ERMP1 PTPRC PTCD2 MUC2	3.42e-03	145	125	4	EFO_0000684
Disease	Obsessive-compulsive trait	TRMT11 HHAT	3.55e-03	21	125	2	HP_0008770
Disease	TNF-related apoptosis-inducing ligand measurement	NOL4 SIPA1L3 PCSK6	3.58e-03	72	125	3	EFO_0008300
Disease	asthma, endometriosis	PLXNB2 C5 IL1R1	3.86e-03	74	125	3	EFO_0001065, MONDO_0004979
Disease	hypertrophic cardiomyopathy (is_implicated_in)	SCO2 SLC25A4	3.89e-03	22	125	2	DOID:11984 (is_implicated_in)
Disease	hemoglobin measurement, mean corpuscular hemoglobin	SCO2 PTPRC	3.89e-03	22	125	2	EFO_0004509, EFO_0004527

Protein segments in the cluster

Peptide	Gene	Start	Entry
YGDHQRFVDAYFKAY	ACSS1	511	Q9NUB1
IYRAAYFGVYDTAKG	SLC25A6	186	P12236
NLYYGHYHGFGDTAE	ANKRD10	371	Q9NXR5
NYGMYAKFINDYGTH	C8A	326	P07357
IGGSDYKLIYRHYAT	AP3S2	56	P59780
HDGYGAYSNHGKYIT	C1QTNF4	291	Q9BXJ3
AYSNHGKYITFSGFL	C1QTNF4	296	Q9BXJ3
AYKHRGNTSGFYYID	CNTNAP4	596	Q9C0A0
HERRNSGYQGYSDYD	BIVM	486	Q86UB2
ENTGLYFDHSTGFYY	AGGF1	211	Q8N302
SFARYGSDFYSMHYK	AMZ2	201	Q86W34
EYSSYNYRGFDIGNH	CHKB	266	Q9Y259
GYFYHTARLTRSGYR	DHX16	946	O60231
YYKNHFSRSSVAAGG	AGTPBP1	806	Q9UPW5
SYASSYHQYGGAYNR	DLX5	96	P56178
KGGDYFVFYSHGLQA	ERMP1	826	Q7Z2K6
GYQRQLNYKHYDGSY	A2M	1011	P01023
LNYKHYDGSYSTFGE	A2M	1016	P01023
EYKATEYGLAYGHFS	ALPK1	1151	Q96QP1
KGGYYYYHNLETQEG	IQGAP1	691	P46940
SYYRGAHGFLVVYDV	RAB1C	76	Q92928
YSAGRGIYSRYHEGK	RBM47	401	A0AV96
DHSLEGRYFQNYSYG	QPCT	286	Q16769
RLGTRGHSKYHYYGI	RFX6	181	Q8HWS3
HYYGIGIKESSAYYH	RFX6	191	Q8HWS3
SAYYHSVYSGKGLTR	RFX6	201	Q8HWS3
LRGYHQHAYDGKDYI	HLA-F	131	P30511
FAHYFTLGSKFRYCG	PTPN4	321	P29074
RYLLYYHSDSNKGQG	IGLV5-52	66	A0A0A0MRZ9
FFELYGRHFNYLKTG	TENT4B	316	Q8NDF8
RTHFDYQFGYRKFDG	LARP1	356	Q6PKG0
YQRTAAYGHFGRDSF	MAT2A	371	P31153
TRALYVHGGYKAFSA	ATRN	511	O75882
KGHVRFIDYEYAGYN	ETNK2	261	Q9NVF9
RHTKFVNDYILYYGG	FRA10AC1	76	Q70Z53
AVHYFYDESGVRRSY	PCNX3	661	Q9H6A9
GALKDYYHFYHSRTI	PCSK5	66	Q92824
GNLEDYYHFYHSKTF	PCSK6	101	P29122
MRIYKYQAHGYAFSG	PCYOX1L	156	Q8NBM8
AFEAYTDHATYKAGY	PLXNB2	196	O15031
YTAISYYHSQFRQGG	FAT2	4271	Q9NYQ8
SIYGSGHYITFDGKY	MUC2	861	Q02817
YSTNGNYDGVLYRHF	PEX6	331	Q13608
NQHFGYLYGRYTEHK	NPLOC4	246	Q8TAT6
YNRFARHPYYGKTGV	GXYLT1	256	Q4G148
KAYEIYHESYAFQGG	LCT	201	P09848
YQKTACYGHFGRSEF	MAT1A	371	Q00266
EGYNSIHYAAAYGHR	ANKRD44	531	Q8N8A2
YLVVALGYHKAYGFS	JAM2	16	P57087
DRYIEFHSQSGFYYK	NOL10	116	Q9BSC4
FALYVGYTRVSDYKH	PLPP2	206	O43688
IQYARKYAYSAASGG	ITGA2	256	P17301
FRSHLQYFGRSLDGY	ITGA2	611	P17301
YGKGSYFARDAAYSH	PARP12	591	Q9H0J9
GFHFYSFYEVYKVSR	HHAT	16	Q5VTY9
NRRYTYLGYAVTAGH	ITGA9	241	Q13797
AGNYGKISYTFFHAS	PCDHB14	271	Q9Y5E9
ERVFDHKQGTYGGYF	EIF3C	871	Q99613
SFAKYLELRFYGHQY	PIKFYVE	1336	Q9Y2I7
LGKEFKEGHSYYYIS	EFNA1	116	P20827
EDGVYFSSYGHYGIH	PRMT3	216	O60678
YGRLTFKYERDSNYH	GLUD1	451	P00367
IEASHYRGYGNSDYK	C5	1386	P01031
SREYHYGNNFGYIVA	CNTN1	731	Q12860
KDHGYTIYSTFGAFY	HTR1A	191	P08908
KEFHYRYNTPGQNYS	AKNAD1	686	Q5T1N1
GLYYFTYHASSRGNL	C1QB	166	P02746
AYLLQGSFYGHSIYA	CERS1	151	P27544
LYAGQYVHSSFSGYL	COL8A1	726	P27658
KYIIDTYGSHGAFYR	MANEAL	241	Q5VSG8
TYGSHGAFYRYKNSM	MANEAL	246	Q5VSG8
SYNEQYLDTYRGHKG	DNAI4	691	Q5VTH9
LFGGFHESTRDYIYY	KLHDC4	191	Q8TBB5
KSYYYAISDFAVGGR	LAMC1	271	P11047
GHSARVYALYYKDGL	FBXW2	146	Q9UKT8
EAFRRYHGYIFGFYK	HEXB	96	P07686
YRYKEASGYFHTLRA	INPP5F	696	Q9Y2H2
ASHSYRVYYNAGPKD	SCO2	201	O43819
YHNLKTRFNYLGFGG	DSEL	721	Q8IZU8
RGNYTCHASYTYLGK	IL1R1	191	P14778
KHTLYHGRDTQYYFV	PKD1L1	1236	Q8TDX9
TAASAYSYYHYGRKT	CRLS1	281	Q9UJA2
YGRLTFKYERDSNYH	GLUD2	451	P49448
YRYHAENKNFTLGEY	PTCD2	116	Q8WV60
YSSNIYKHGDTGRRY	FGF20	151	Q9NP95
YQGHNSFREKYFSGV	TRMT11	436	Q7Z4G4
YGVLGSQYFSSGKHY	TRIM34	336	Q9BYJ4
GLTFYHAPRTKNYGY	RSPH9	246	Q9H1X1
NYIGSDKYFHARGNY	SAA2	46	P0DJI9
YTVARIKLGDYHFYG	SEL1L	626	Q9UBV2
YNGYYSDLSTARHSG	NKTR	411	P30414
LGTRGNSKYHYYGLR	RFX1	496	P22670
RLGTRGNSKYHYYGI	RFX2	256	P48378
LGTRGNSKYHYYGIR	RFX3	241	P48380
FGKYHDGDFNVRSGY	TMEM184A	206	Q6ZMB5
AFARVKIGDYHYYGY	SEL1L2	551	Q5TEA6
YCFRTSKGVGYSAHF	NBEA	281	Q8NFP9
KYGRAHPVFYQGTYS	FAF2	146	Q96CS3
HVDLGARYYQDYFVG	SIPA1L3	496	O60292
ARYYQDYFVGKEHAN	SIPA1L3	501	O60292
AYSLEHADLGAGYYR	SIPA1	206	Q96FS4
TGHVVYNGAFYYNRA	OLFML2B	566	Q68BL8
YSSADPRGVHFYYNK	NOX3	551	Q9HBY0
FSSRAKEFAFYHQGY	HOXA13	221	P31271
YINGNGTYSYHSYRG	NOL4	546	O94818
NYIGSDKYFHARGNY	SAA1	46	P0DJI8
YAHNGKQYRYVFATG	BCO1	411	Q9HAY6
IYRAAYFGVYDTAKG	SLC25A4	186	P12235
YLAKYHGFGNVHAYL	CDCA7	346	Q9BWT1
SVQYREYGLHAAGLY	NCAPD3	106	P42695
RYKYGYNAGEATHHA	SPART	576	Q8N0X7
RGDTGHKAYEYQEYG	ZNF700	146	Q9H0M5
YRQQLSEHSKRGYYG	TJP2	1166	Q9UDY2
SEHSKRGYYGQSARY	TJP2	1171	Q9UDY2
AKISGHHYPYRAGSY	VSIG8	181	P0DPA2
HDGYYFSYVKAQEGQ	USP17L4	331	A6NCW7
RFSHLVGYGARYYSY	MIPEP	621	Q99797
TGGFDRTRHYDQDYY	SPEN	156	Q96T58
VEKTYYYQGDFHISG	TMPRSS11B	41	Q86T26
FFMGYYRYSKETHIN	SLCO1B3	116	Q9NPD5
GLSYYHTYDRFFLGV	PIGN	431	O95427
SADGYSLYRYHFNGE	TRPM1	1266	Q7Z4N2
ECGKGFYYSYSLTRH	ZNF80	221	P51504
AYSNLGSAYHYRRNF	TTC28	396	Q96AY4
IEHATGFYTGSYYFD	WSCD1	371	Q658N2
RYTDAHYAKSGYGAY	USP2	16	O75604
YSTDYTFKAYFHNGD	PTPRC	546	P08575
KNETYQYYGFSHTVG	TRPV4	801	Q9HBA0
FKATYRAGIAFYHLG	TTC9B	171	Q8N6N2
YYLKYFSGAHDGDVY	ZBTB7A	351	O95365
ALYRSGVAFYHLGDY	TTC9	166	Q92623
HRYYFEVEIFGAGTY	TRIM16L	211	Q309B1
GYAHFTLSGDYYNRA	VPS13D	2746	Q5THJ4
AREKNFHIFYYIYAG	MYO3B	526	Q8WXR4
FEYNSYDNHTYGKRA	MYT1L	646	Q9UL68