Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein-arginine deiminase activity

PADI4 PADI3

3.51e-055382GO:0004668
GeneOntologyMolecularFunctionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

PADI4 PADI3

1.92e-0411382GO:0016813
GeneOntologyMolecularFunctionvoltage-gated monoatomic anion channel activity

GPR89A GPR89B

4.71e-0417382GO:0008308
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

FOXD4L4 FOXD4L6 MLXIP FOXD4L1 FOXD4L3 FOXF1 IKZF4 FOXD4L5

2.03e-031244388GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

FOXD4L4 FOXD4L6 MLXIP FOXD4L1 FOXD4L3 FOXF1 IKZF4 FOXD4L5

2.32e-031271388GO:0000987
DomainTF_fork_head_CS_2

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXF1 FOXD4L5

3.49e-1046376IPR030456
DomainTF_fork_head_CS_1

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXF1 FOXD4L5

4.00e-1047376IPR018122
DomainFORK_HEAD_3

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXF1 FOXD4L5

5.19e-1049376PS50039
DomainFH

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXF1 FOXD4L5

5.19e-1049376SM00339
DomainFORK_HEAD_1

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXF1 FOXD4L5

5.19e-1049376PS00657
DomainFORK_HEAD_2

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXF1 FOXD4L5

5.19e-1049376PS00658
DomainForkhead

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXF1 FOXD4L5

5.19e-1049376PF00250
DomainFork_head_dom

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXF1 FOXD4L5

5.19e-1049376IPR001766
Domain-

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXF1 FOXD4L5

4.06e-062183761.10.10.10
DomainWHTH_DNA-bd_dom

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXF1 FOXD4L5

7.39e-06242376IPR011991
DomainPAD_C

PADI4 PADI3

3.80e-055372IPR013530
DomainProt_Arg_deaminase_cen_dom

PADI4 PADI3

3.80e-055372IPR013733
DomainPAD_N

PADI4 PADI3

3.80e-055372IPR013732
DomainPAD

PADI4 PADI3

3.80e-055372PF03068
DomainPAD_N

PADI4 PADI3

3.80e-055372PF08526
DomainPAD_M

PADI4 PADI3

3.80e-055372PF08527
DomainPAD

PADI4 PADI3

3.80e-055372IPR004303
DomainCupredoxin

PADI4 PADI3

8.60e-0422372IPR008972
Pubmed

Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXF1 FOXD4L5

2.67e-15134067957066
Pubmed

Neural transcription factors bias cleavage stage blastomeres to give rise to neural ectoderm.

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXD4L5

9.31e-15640527092474
Pubmed

Forkhead transcription factor Foxf2 (LUN)-deficient mice exhibit abnormal development of secondary palate.

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXF1 FOXD4L5

5.98e-142040612812790
Pubmed

The mouse fkh-2 gene. Implications for notochord, foregut, and midbrain regionalization.

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXD4L5

8.67e-1484058530406
Pubmed

An amphioxus winged helix/forkhead gene, AmphiFoxD: insights into vertebrate neural crest evolution.

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXD4L5

1.95e-13940512412011
Pubmed

A genetic study of the suppressors of the Engrailed-1 cerebellar phenotype.

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXD4L5

1.98e-121340516884697
Pubmed

Six members of the mouse forkhead gene family are developmentally regulated.

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXD4L5

4.62e-12154057689224
Pubmed

Strain-specific modifier genes of Cecr2-associated exencephaly in mice: genetic analysis and identification of differentially expressed candidate genes.

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXD4L5

4.62e-121540522045912
Pubmed

Expression of the winged helix genes fkh-4 and fkh-5 defines domains in the central nervous system.

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXD4L5

6.72e-12164058861101
Pubmed

Developmental competence of the gut endoderm: genetic potentiation by GATA and HNF3/fork head proteins.

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXD4L5

6.72e-121640510208738
Pubmed

Functional equivalency between Otx2 and Otx1 in development of the rostral head.

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXD4L5

1.78e-11194059895322
Pubmed

Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification.

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXD4L5

3.12e-11214059449667
Pubmed

Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes.

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXD4L5

4.03e-112240517389379
Pubmed

Otx2 is required to respond to signals from anterior neural ridge for forebrain specification.

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXD4L5

6.49e-112440511820816
Pubmed

A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity.

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXD4L5

6.49e-112440529992973
Pubmed

Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex.

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXD4L5

1.00e-102640515857913
Pubmed

Genome-scale study of transcription factor expression in the branching mouse lung.

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXF1 FOXD4L5

1.48e-106740622711520
Pubmed

Molecular profiling of synovial joints: use of microarray analysis to identify factors that direct the development of the knee and elbow.

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXD4L5

1.81e-102940522972626
Pubmed

FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines.

FOXD4L4 FOXD4L6 FOXD4L5

1.41e-08540312234674
Pubmed

Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.

PI4K2B FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 AGL FOXD4L5

5.54e-0830640718973680
Pubmed

Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions.

FOXD4L4 FOXD4L1 FOXD4L3

2.31e-071140312421752
Pubmed

Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 IKZF4 FOXD4L5

5.46e-0726340620932939
Pubmed

Association of cross-reactive antibodies targeting peptidyl-arginine deiminase 3 and 4 with rheumatoid arthritis-associated interstitial lung disease.

PADI4 PADI3

1.29e-06240224901704
Pubmed

GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus.

GPR89A GPR89B

1.29e-06240218794847
Pubmed

GPHR-dependent functions of the Golgi apparatus are essential for the formation of lamellar granules and the skin barrier.

GPR89A GPR89B

1.29e-06240222572823
Pubmed

Diverse fates of paralogs following segmental duplication of telomeric genes.

FOXD4L4 FOXD4L1 FOXD4L3

2.14e-062240315233989
Pubmed

Peptidylarginine Deiminase Isozyme-Specific PAD2, PAD3 and PAD4 Inhibitors Differentially Modulate Extracellular Vesicle Signatures and Cell Invasion in Two Glioblastoma Multiforme Cell Lines.

PADI4 PADI3

3.87e-06340232098295
Pubmed

The amount of citrullinated proteins in synovial tissue is related to serum anti-cyclic citrullinated peptide (anti-CCP) antibody levels.

PADI4 PADI3

3.87e-06340226255191
Pubmed

Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function.

GPR89A GPR89B

3.87e-06340232220963
Pubmed

Neutrophils license iNKT cells to regulate self-reactive mouse B cell responses.

PADI4 FASLG

3.87e-06340227798616
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

GPR89A GPR89B CHD9 VCP AP3B2

4.05e-0620840533230847
Pubmed

Peptidylarginine deiminase 1-catalyzed histone citrullination is essential for early embryo development.

PADI4 PADI3

7.73e-06440227929094
Pubmed

Cerebellar Neurodegeneration and Neuronal Circuit Remodeling in Golgi pH Regulator-Deficient Mice.

GPR89A GPR89B

7.73e-06440231118204
Pubmed

Molecular cloning of cDNAs of mouse peptidylarginine deiminase type I, type III and type IV, and the expression pattern of type I in mouse.

PADI4 PADI3

7.73e-06440210092850
Pubmed

Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6.

PADI4 PADI3

1.93e-05640215087120
Pubmed

Gene expression profiling of arthritis using a QTL chip reveals a complex gene regulation of the Cia5 region in mice.

GPR89A GPR89B

2.70e-05740216015370
Pubmed

Sporadic Hirschsprung Disease: Mutational Spectrum and Novel Candidate Genes Revealed by Next-generation Sequencing.

AGL AP3B2

2.70e-05740229093530
Pubmed

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

GPR89A GPR89B VCP RAB3IP IHO1

9.49e-0540240524722188
Pubmed

A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 IKZF4 FOXD4L5

1.49e-0470940622988430
Pubmed

Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.

GPR89A GPR89B FASLG

1.76e-049440312761501
Pubmed

The role of RNF149 in the pre-emptive quality control substrate ubiquitination.

EMC8 VCP

2.42e-042040237031316
Pubmed

Stasimon/Tmem41b localizes to mitochondria-associated ER membranes and is essential for mouse embryonic development.

GPR89A GPR89B VCP

3.02e-0411340330352685
Pubmed

A GO catalogue of human DNA-binding transcription factors.

ZNF688 SKIDA1

1.08e-034240234673265
Pubmed

The DNA sequence and biological annotation of human chromosome 1.

GPR89A GPR89B NT5C1A PADI4 FASLG PADI3

1.08e-03103140616710414
Cytoband9q21.11

FOXD4L4 FOXD4L6 FOXD4L3 FOXD4L5

1.33e-08304049q21.11
Cytoband16q24

EMC8 FOXF1

9.98e-051740216q24
CytobandEnsembl 112 genes in cytogenetic band chr9q21

FOXD4L4 FOXD4L3 FOXD4L5

7.04e-04199403chr9q21
Cytoband1p36.13

PADI4 PADI3

1.11e-03564021p36.13
Cytoband1q21.1

GPR89A GPR89B

1.35e-03624021q21.1
CytobandEnsembl 112 genes in cytogenetic band chr16q24

EMC8 FOXF1

6.31e-03136402chr16q24
GeneFamilyPeptidyl arginine deiminases

PADI4 PADI3

1.41e-055222677
GeneFamilyEndogenous ligands|Minor histocompatibility antigens

PI4K2B BCAT2

1.74e-0351222870
GeneFamilyPDZ domain containing

MAST3 AHNAK2

1.45e-021522221220
CoexpressionMIKKELSEN_NPC_HCP_WITH_H3K4ME3_AND_H3K27ME3

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXF1 AP3B2 FOXD4L5

2.97e-08217397MM861
CoexpressionMORI_MATURE_B_LYMPHOCYTE_UP

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXD4L5

5.08e-07106395MM595
CoexpressionMEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXF1 FOXD4L5

1.37e-05357396MM828
CoexpressionMEISSNER_BRAIN_HCP_WITH_H3K27ME3

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXD4L5

5.94e-05282395MM822
ToppCellwk_15-18-Hematologic-Myeloid-aDC_1|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3 FOXD4L5

5.24e-07177405ccf5dc54780d6039a4d062dee88440c011ddc0a3
ToppCell5'-GW_trimst-2-LymphNode-Hematopoietic-Myeloid-Lymphoid_DC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3

1.54e-051684046dd58fd981750da49afd53796f244e1803cce97f
ToppCellmetastatic_Brain-Fibroblasts-Undetermined|Fibroblasts / Location, Cell class and cell subclass

PI4K2B TBXAS1 RAB3IP AHNAK2

1.69e-05172404c3822ff7329c3ac38c68c5c38cd67c390682e2a6
ToppCellwk_20-22-Hematologic-Myeloid-aDC_1|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

FOXD4L4 FOXD4L6 FOXD4L1 FOXD4L3

1.94e-05178404fd2bdb4796e86c8cff2d25f0c730ffea21db8787
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_10|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

FOXD4L4 FOXD4L1 FOXD4L3 FOXD4L5

2.02e-0518040432d871738a24071b70084a7e80148a516110c78b
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_10|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

FOXD4L4 FOXD4L1 FOXD4L3 FOXD4L5

2.02e-05180404067ca8a15228c7f3b3bc7aecbc9b1611ca05e176
ToppCell(2)_Fibroblasts-(21)_Fibro-2|World / Cell class and subclass of bone marrow stroma cells in homeostatis

TBXAS1 SASH1 PADI3 AHNAK2

2.55e-051914045ee353c79055c08e8a3e2b43a0345bceb09f3890
ToppCell(6)_Endothelial-C_(Capillary_Aerocyte_)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

BCAT2 HTR3C SASH1 FOXF1

2.66e-05193404f7f2dc6aff02d096a282835094d26d12b3b73e61
DiseaseDrug Allergy

TBXAS1 FASLG

7.94e-0435352C0013182
Diseasevaline measurement

BCAT2 MLXIP

1.04e-0340352EFO_0009792
Diseaseautoimmune disease

PADI4 SASH1 FASLG

1.13e-03173353EFO_0005140
Diseaseeosinophil count

TBXAS1 EMC8 NEURL1B CTSC IKZF4 MAST3 IHO1

1.58e-031488357EFO_0004842
DiseaseIGA glomerulonephritis

PADI4 PADI3

2.17e-0358352EFO_0004194

Protein segments in the cluster

PeptideGeneStartEntry
GAPKGPLLEKIRPHI

NT5C1A

311

Q9BXI3
GLGLTLTHLPGPKEP

HTR3C

371

Q8WXA8
TPIKGLHVGTPKLPA

AP3B2

901

Q13367
PLPGGKTPFKKGHTR

RAB3IP

271

Q96QF0
VLGKHLGIPKPFGPV

PADI4

591

Q9UM07
GLFPPPLSVGKSKGL

IHO1

101

Q8IYA8
FVKIPREPGHPGKGN

FOXD4L4

166

Q8WXT5
FVKIPREPGHPGKGN

FOXD4L3

166

Q6VB84
TLKHKGPPGRAPIPH

IQSEC2

631

Q5JU85
AGKRAPPTGGIKKPH

H3Y1

26

P0DPK2
LVLGKHLGIPKPFGP

PADI3

591

Q9ULW8
GRKFHRIGLPPKIGS

PI4K2B

241

Q8TCG2
LTGGRPKQPHKIVPA

MLXIP

546

Q9HAP2
HLGLSAPVPRGRKGK

CHD9

1571

Q3L8U1
PPKLPHTGIGKRGLF

DNAH6

146

Q9C0G6
KLGDPFPILSPKHGI

GPR89A

126

B7ZAQ6
KLGDPFPILSPKHGI

GPR89B

126

P0CG08
GGHSRKIPRPKPAPL

CTSC

206

P53634
LHGLAAKLGPPRPKT

MAST3

1161

O60307
VSGKLLGAPPRPGHK

ITIH6

1121

Q6UXX5
VKIPREPGHPGKGTY

FOXD4L1

166

Q9NU39
KPRKEHLPLGGPGAH

EMC8

36

O43402
HKKPGPGEPLVFGKT

BCAT2

46

O15382
HPLSVKFPKGRVIPG

CFAP47

1356

Q6ZTR5
PHSPGGIRLPNGKLK

IKZF4

146

Q9H2S9
APVSGKKHRPPGPLF

nan

271

A6NNC1
TAPVSGKKHRPPGPL

nan

541

A6NNC1
GPRKVFLGKPTLPHA

MMP20

271

O60882
IKTHFLKPPGKRPAG

FER1L6

756

Q2WGJ9
FIKLPKGLGRPGKGH

FOXF1

106

Q12946
RHFLGTGKPPHPLGR

TDRG1

11

Q3Y452
FVKIPREPGHPGKGN

FOXD4L5

166

Q5VV16
FVKIPREPGHPGKGN

FOXD4L6

166

Q3SYB3
GGSAIPLPPSHKFRK

SKIDA1

891

Q1XH10
GPLPEGASLKGHLPK

AHNAK2

746

Q8IVF2
KLGLRHPKPSPFIGN

TBXAS1

41

P24557
HPALFKAIGVKPPRG

VCP

226

P55072
AKLGHLALGRAPGPP

NEURL1B

236

A8MQ27
PPGAKHGLARTPLEG

SASH1

936

O94885
LPLPPLKKRGNHSTG

FASLG

66

P48023
HLGALGFPGPKPALI

ZNF688

61

P0C7X2
GHGPKLGPVTRKHPL

AGL

411

P35573