Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionaspartic-type endopeptidase activity

ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-25 DDI1

1.23e-0937606GO:0004190
GeneOntologyMolecularFunctionaspartic-type peptidase activity

ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-25 DDI1

1.46e-0938606GO:0070001
GeneOntologyMolecularFunctionRNA stem-loop binding

ERVK-6 MYH10 ERVK-8 ERVK-7

4.24e-0721604GO:0035613
GeneOntologyMolecularFunctionRNA-DNA hybrid ribonuclease activity

ERVK-6 ERVK-8 ERVK-7

4.18e-0611603GO:0004523
GeneOntologyMolecularFunctionsteroid 11-beta-monooxygenase activity

CYP11B1 CYP11B2

8.88e-062602GO:0004507
GeneOntologyMolecularFunctioncorticosterone 18-monooxygenase activity

CYP11B1 CYP11B2

8.88e-062602GO:0047783
GeneOntologyMolecularFunctionRNA-directed DNA polymerase activity

ERVK-6 ERVK-8 ERVK-7

9.17e-0614603GO:0003964
GeneOntologyMolecularFunctionsteroid hydroxylase activity

CYP2R1 CYP11B1 CYP11B2

1.44e-0434603GO:0008395
GeneOntologyMolecularFunctiontransition metal ion binding

ERVK-6 ZSWIM8 TRAF4 CYP2R1 ENPP1 CYP11B1 CYP11B2 EGLN1 ERVK-8 ERVK-19 ERVK-7 D2HGDH

1.84e-0411896012GO:0046914
GeneOntologyMolecularFunctionRNA endonuclease activity, producing 5'-phosphomonoesters

ERVK-6 ERVK-8 ERVK-7

1.86e-0437603GO:0016891
GeneOntologyMolecularFunctionDNA polymerase activity

ERVK-6 ERVK-8 ERVK-7

2.02e-0438603GO:0034061
GeneOntologyMolecularFunctionendonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

ERVK-6 ERVK-8 ERVK-7

3.57e-0446603GO:0016893
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

CYP11B1 CYP11B2

6.78e-0413602GO:0016713
GeneOntologyMolecularFunctionphosphatidylinositol 3-kinase regulatory subunit binding

DAB2IP PTPN13

7.89e-0414602GO:0036312
GeneOntologyMolecularFunctioniron ion binding

CYP2R1 CYP11B1 CYP11B2 EGLN1

1.56e-03166604GO:0005506
GeneOntologyMolecularFunctionRNA endonuclease activity

ERVK-6 ERVK-8 ERVK-7

1.73e-0379603GO:0004521
GeneOntologyMolecularFunctionendopeptidase activity

ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-25 DDI1

1.81e-03430606GO:0004175
GeneOntologyMolecularFunctionubiquitin-like ligase-substrate adaptor activity

ZSWIM8 KLHL25 PRAMEF13

1.93e-0382603GO:1990756
GeneOntologyMolecularFunction3',5'-cyclic-AMP phosphodiesterase activity

ENPP1 PDE10A

1.97e-0322602GO:0004115
GeneOntologyMolecularFunction3',5'-cyclic-nucleotide phosphodiesterase activity

ENPP1 PDE10A

2.55e-0325602GO:0004114
GeneOntologyMolecularFunctionhydrolase activity, acting on ester bonds

PLCD3 ERVK-6 PTPN13 DUSP21 ENPP1 ERVK-8 ERVK-7 PDE10A

2.74e-03807608GO:0016788
GeneOntologyMolecularFunctionK63-linked polyubiquitin modification-dependent protein binding

IKBKE PRPF8

2.75e-0326602GO:0070530
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

CYP2R1 CYP11B1 CYP11B2 EGLN1

2.76e-03194604GO:0016705
GeneOntologyMolecularFunctionenzyme-substrate adaptor activity

ZSWIM8 KLHL25 PRAMEF13

2.93e-0395603GO:0140767
GeneOntologyMolecularFunctioncyclic-nucleotide phosphodiesterase activity

ENPP1 PDE10A

2.97e-0327602GO:0004112
GeneOntologyMolecularFunctionphosphoric diester hydrolase activity

PLCD3 ENPP1 PDE10A

3.11e-0397603GO:0008081
GeneOntologyMolecularFunctionpeptidase activity

ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-25 DDI1 PRPF8

3.36e-03654607GO:0008233
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

DAB2IP STARD13 TAGAP KIAA1755 TSC2 ARHGEF16

4.08e-03507606GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

DAB2IP STARD13 TAGAP KIAA1755 TSC2 ARHGEF16

4.08e-03507606GO:0030695
GeneOntologyMolecularFunctionzinc ion binding

ERVK-6 ZSWIM8 TRAF4 ENPP1 ERVK-8 ERVK-19 ERVK-7 D2HGDH

4.99e-03891608GO:0008270
GeneOntologyMolecularFunctionmonooxygenase activity

CYP2R1 CYP11B1 CYP11B2

5.02e-03115603GO:0004497
GeneOntologyMolecularFunctionnuclease activity

ERVK-6 ENPP1 ERVK-8 ERVK-7

5.13e-03231604GO:0004518
GeneOntologyMolecularFunctionphosphoric ester hydrolase activity

PLCD3 PTPN13 DUSP21 ENPP1 PDE10A

6.01e-03386605GO:0042578
GeneOntologyMolecularFunction14-3-3 protein binding

DAB2IP TSC2

7.08e-0342602GO:0071889
GeneOntologyMolecularFunctionphosphatidylinositol 3-kinase binding

DAB2IP PTPN13

7.41e-0343602GO:0043548
GeneOntologyMolecularFunctionsteroid binding

CYP2R1 CYP11B1 CYP11B2

7.50e-03133603GO:0005496
GeneOntologyMolecularFunctionRNA nuclease activity

ERVK-6 ERVK-8 ERVK-7

7.97e-03136603GO:0004540
GeneOntologyMolecularFunctionendonuclease activity

ERVK-6 ERVK-8 ERVK-7

7.97e-03136603GO:0004519
GeneOntologyBiologicalProcessDNA integration

ERVK-6 ERVK-8 ERVK-7

6.56e-0613603GO:0015074
GeneOntologyBiologicalProcessregulation of blood volume by renal aldosterone

CYP11B1 CYP11B2

4.97e-054602GO:0002017
GeneOntologyCellularComponentdendrite

DAB2IP MYH10 KCND1 ENPP1 CYP11B1 CYP11B2 COBL TSC2 TRAK2

7.15e-04858609GO:0030425
GeneOntologyCellularComponentcleavage furrow

PLCD3 MYH10 RDX

7.19e-0461603GO:0032154
GeneOntologyCellularComponentdendritic tree

DAB2IP MYH10 KCND1 ENPP1 CYP11B1 CYP11B2 COBL TSC2 TRAK2

7.27e-04860609GO:0097447
GeneOntologyCellularComponentsite of polarized growth

FRY MYH10 COBL TSC2 TRAK2

7.92e-04253605GO:0030427
GeneOntologyCellularComponentcell tip

RDX MSN

1.07e-0317602GO:0051286
GeneOntologyCellularComponentcell body

DAB2IP MYH10 PTPN13 KCND1 ENPP1 COBL TSC2 TRAK2 PDE10A

1.25e-03929609GO:0044297
GeneOntologyCellularComponentcell pole

RDX MSN

1.49e-0320602GO:0060187
GeneOntologyCellularComponentcell division site

PLCD3 MYH10 RDX

1.58e-0380603GO:0032153
MousePhenoabnormal urine progesterone level

CYP11B1 CYP11B2

9.24e-062432MP:0011545
MousePhenoabnormal urine deoxycorticosterone level

CYP11B1 CYP11B2

9.24e-062432MP:0011552
MousePhenodecreased urine corticosterone level

CYP11B1 CYP11B2

9.24e-062432MP:0011550
MousePhenoincreased urine deoxycorticosterone level

CYP11B1 CYP11B2

9.24e-062432MP:0011553
MousePhenoincreased urine progesterone level

CYP11B1 CYP11B2

9.24e-062432MP:0011546
MousePhenoabnormal adrenal gland zona glomerulosa morphology

CYP11B1 CYP11B2

5.52e-054432MP:0008293
MousePhenodecreased urine aldosterone level

CYP11B1 CYP11B2

5.52e-054432MP:0011541
MousePhenoabnormal urine aldosterone level

CYP11B1 CYP11B2

5.52e-054432MP:0011539
MousePhenoabnormal urine corticosterone level

CYP11B1 CYP11B2

5.52e-054432MP:0011548
MousePhenodecreased urine hormone level

CYP11B1 CYP11B2

5.52e-054432MP:0014459
MousePhenoabnormal cerebral aqueduct morphology

MYH10 CCDC85C RFX4

7.53e-0527433MP:0005537
MousePhenoincreased adrenal gland zona fasciculata size

CYP11B1 CYP11B2

9.19e-055432MP:0014286
MousePhenouterus adenomyosis

CYP11B1 CYP11B2

1.38e-046432MP:0009221
MousePhenoincreased urine hormone level

CYP11B1 CYP11B2

1.38e-046432MP:0014458
MousePhenoadrenal gland hyperplasia

CYP11B1 CYP11B2

1.38e-046432MP:0009078
MousePhenoabnormal urine hormone level

CYP11B1 CYP11B2

1.92e-047432MP:0011538
MousePhenopituitary gland hyperplasia

CYP11B1 CYP11B2

1.92e-047432MP:0000635
MousePhenoincreased circulating angiotensin II level

CYP11B1 CYP11B2

2.56e-048432MP:0031232
MousePhenoincreased angiotensin II level

CYP11B1 CYP11B2

2.56e-048432MP:0031229
MousePhenodecreased circulating renin level

CYP11B1 CYP11B2

4.09e-0410432MP:0003353
MousePhenoabnormal adrenocortical cell morphology

CYP11B1 CYP11B2

4.09e-0410432MP:0008291
MousePhenocerebral aqueductal stenosis

CCDC85C RFX4

4.09e-0410432MP:0002958
MousePhenoabnormal adrenal gland zona fasciculata size

CYP11B1 CYP11B2

4.99e-0411432MP:0014284
MousePhenoglobular heart

ZSWIM8 MYH10

4.99e-0411432MP:0031511
MousePhenouterus cyst

CYP11B1 CYP11B2

4.99e-0411432MP:0009082
MousePhenoincreased myocardial fiber size

MYH10 CYP11B1 CYP11B2

5.71e-0453433MP:0004564
MousePhenoabnormal circulating angiotensin II level

CYP11B1 CYP11B2

5.98e-0412432MP:0031230
MousePhenoabnormal angiotensin II level

CYP11B1 CYP11B2

5.98e-0412432MP:0031227
MousePhenohypokalemia

CYP11B1 CYP11B2

5.98e-0412432MP:0004119
MousePhenoenlarged pituitary gland

CYP11B1 CYP11B2

5.98e-0412432MP:0000636
MousePhenoabnormal heart size

ZSWIM8 NLRP9 MYH10 ENPP1 CYP11B1 CYP11B2 EGLN1 COBL TSC2 PRAMEF13 MSN

6.81e-0411804311MP:0005406
MousePhenoincreased renin activity

CYP11B1 CYP11B2

8.22e-0414432MP:0005582
MousePhenodecreased circulating mineralocorticoid level

CYP11B1 CYP11B2

8.22e-0414432MP:0003374
MousePhenoincreased urine osmolality

CYP11B1 CYP11B2

8.22e-0414432MP:0008055
MousePhenoincreased circulating adrenocorticotropin level

CYP11B1 CYP11B2

8.22e-0414432MP:0001748
MousePhenodecreased circulating aldosterone level

CYP11B1 CYP11B2

8.22e-0414432MP:0002667
MousePhenoendometrium hyperplasia

CYP11B1 CYP11B2

8.22e-0414432MP:0009092
MousePhenoobstructive hydrocephaly

CCDC85C RFX4

1.08e-0316432MP:0000917
MousePhenodecreased circulating mineral level

MTIF3 FRMD4A CYP2R1 ENPP1 CYP11B1 CYP11B2

1.17e-03391436MP:0014548
DomainFERM_C

FRMD4A PTPN13 RDX MSN

8.25e-0726534PF09380
DomainFERM_C

FRMD4A PTPN13 RDX MSN

9.66e-0727534SM01196
DomainFERM_PH-like_C

FRMD4A PTPN13 RDX MSN

9.66e-0727534IPR018980
DomainFERM_N

FRMD4A PTPN13 RDX MSN

2.22e-0633534PF09379
DomainFERM_N

FRMD4A PTPN13 RDX MSN

2.22e-0633534IPR018979
DomainCyt_P450_mitochondrial

CYP11B1 CYP11B2

7.90e-062532IPR002399
DomainFERM_M

FRMD4A PTPN13 RDX MSN

8.63e-0646534PF00373
Domain-

FRMD4A PTPN13 RDX MSN

1.11e-05495341.20.80.10
DomainFERM_central

FRMD4A PTPN13 RDX MSN

1.11e-0549534IPR019748
DomainFERM_domain

FRMD4A PTPN13 RDX MSN

1.11e-0549534IPR000299
DomainFERM_1

FRMD4A PTPN13 RDX MSN

1.21e-0550534PS00660
DomainFERM_2

FRMD4A PTPN13 RDX MSN

1.21e-0550534PS00661
DomainFERM_3

FRMD4A PTPN13 RDX MSN

1.21e-0550534PS50057
DomainBand_41_domain

FRMD4A PTPN13 RDX MSN

1.21e-0550534IPR019749
DomainB41

FRMD4A PTPN13 RDX MSN

1.21e-0550534SM00295
DomainFERM/acyl-CoA-bd_prot_3-hlx

FRMD4A PTPN13 RDX MSN

1.21e-0550534IPR014352
DomainEz/rad/moesin-like

FRMD4A RDX MSN

2.77e-0521533IPR000798
DomainFERM_CS

FRMD4A RDX MSN

4.19e-0524533IPR019747
DomainERM_C_dom

RDX MSN

4.72e-054532IPR011259
DomainERM

RDX MSN

4.72e-054532PF00769
DomainERM

RDX MSN

4.72e-054532IPR011174
Domain-

DAB2IP PLCD3 FRMD4A PTPN13 RDX ARHGEF16 MSN

1.12e-043915372.30.29.30
DomainMoesin_tail

RDX MSN

1.64e-047532IPR008954
DomainUbiquitin-rel_dom

FRMD4A PTPN13 RDX DDI1 MSN

1.72e-04184535IPR029071
DomainPH_dom-like

DAB2IP PLCD3 FRMD4A PTPN13 RDX ARHGEF16 MSN

1.91e-04426537IPR011993
DomainCyt_P450_CS

CYP2R1 CYP11B1 CYP11B2

4.57e-0453533IPR017972
DomainCYTOCHROME_P450

CYP2R1 CYP11B1 CYP11B2

5.67e-0457533PS00086
Domain-

CYP2R1 CYP11B1 CYP11B2

5.96e-04585331.10.630.10
Domainp450

CYP2R1 CYP11B1 CYP11B2

5.96e-0458533PF00067
DomainCyt_P450

CYP2R1 CYP11B1 CYP11B2

6.59e-0460533IPR001128
DomainDAPIN

NLRP12 NLRP9

1.76e-0322532PS50824
DomainPYRIN

NLRP12 NLRP9

1.76e-0322532PF02758
DomainDAPIN

NLRP12 NLRP9

1.76e-0322532IPR004020
DomainPYRIN

NLRP12 NLRP9

1.76e-0322532SM01289
DomainNACHT

NLRP12 NLRP9

1.92e-0323532PS50837
DomainNACHT_NTPase

NLRP12 NLRP9

1.92e-0323532IPR007111
DomainRho_GTPase_activation_prot

DAB2IP STARD13 TAGAP

2.00e-0388533IPR008936
PathwayKEGG_MEDICUS_REFERENCE_STEROID_HORMONE_BIOSYNTHESIS_PROGESTERONE_TO_CORTISOL_CORTISONE

CYP11B1 CYP11B2

5.96e-055352M47522
PathwayREACTOME_METABOLIC_DISORDERS_OF_BIOLOGICAL_OXIDATION_ENZYMES

CYP2R1 CYP11B1 CYP11B2

7.96e-0534353M27461
PathwayWP_CHOLESTEROL_BIOSYNTHESIS_PATHWAY_IN_HEPATOCYTES

CYP2R1 CYP11B1 CYP11B2 SREBF1

1.58e-04111354M48065
PathwayWP_OXIDATION_BY_CYTOCHROME_P450

CYP2R1 CYP11B1 CYP11B2

1.62e-0443353MM15873
PathwayREACTOME_METABOLISM_OF_STEROIDS

CYP2R1 CYP11B1 CYP11B2 SREBF1

2.57e-04126354MM15553
PathwayREACTOME_GLUCOCORTICOID_BIOSYNTHESIS

CYP11B1 CYP11B2

2.66e-0410352M27076
PathwayREACTOME_GLUCOCORTICOID_BIOSYNTHESIS

CYP11B1 CYP11B2

3.25e-0411352MM14750
PathwayWP_PTDINS45P2_IN_CYTOKINESIS_PATHWAY

RDX MSN

3.89e-0412352M45558
PathwayREACTOME_MINERALOCORTICOID_BIOSYNTHESIS

CYP11B1 CYP11B2

3.89e-0412352MM14749
PathwayWP_OXIDATION_BY_CYTOCHROME_P450

CYP2R1 CYP11B1 CYP11B2

4.80e-0462353M39653
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

CYP2R1 CYP11B1 CYP11B2

5.27e-0464353M5650
PathwayWP_GLUCOCORTICOID_BIOSYNTHESIS

CYP11B1 CYP11B2

5.35e-0414352M46449
PathwayWP_MINERALOCORTICOID_BIOSYNTHESIS

CYP11B1 CYP11B2

5.35e-0414352M46453
PathwayREACTOME_METABOLISM_OF_STEROIDS

CYP2R1 CYP11B1 CYP11B2 SREBF1

5.51e-04154354M27832
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

CYP2R1 CYP11B1 CYP11B2

5.76e-0466353MM14839
PathwayWP_ID_SIGNALING

RBL1 SREBF1

7.03e-0416352M39359
PathwayWP_CLASSICAL_PATHWAY_OF_STEROIDOGENESIS_WITH_GLUCOCORTICOID_AND_MINERALOCORTICOID_METABOLISM

CYP11B1 CYP11B2

7.03e-0416352M39815
PathwayWP_FGF23_SIGNALING_IN_HYPOPHOSPHATEMIC_RICKETS_AND_RELATED_DISORDERS

ENPP1 CYP11B2

1.47e-0323352M39862
PathwayREACTOME_CDC42_GTPASE_CYCLE

STARD13 TAGAP ARHGEF16

1.61e-0394353MM15598
PathwayREACTOME_ENDOGENOUS_STEROLS

CYP11B1 CYP11B2

1.73e-0325352M11184
PathwayREACTOME_ENDOGENOUS_STEROLS

CYP11B1 CYP11B2

2.02e-0327352MM14844
PathwayREACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS

CYP2R1 CYP11B1 CYP11B2

2.15e-03104353M738
PathwayREACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS

CYP2R1 CYP11B1 CYP11B2

2.21e-03105353MM14842
Pubmed

Cortical mechanics and meiosis II completion in mammalian oocytes are mediated by myosin-II and Ezrin-Radixin-Moesin (ERM) proteins.

MYH10 RDX MSN

2.05e-08461320660156
Pubmed

Quantitation of HERV-K env gene expression and splicing in human breast cancer.

ERVK-6 ERVK-19 ERVK-7

5.12e-08561312629516
Pubmed

A revised nomenclature for transcribed human endogenous retroviral loci.

ERVK-6 ERVK-8 ERVK-19 ERVK-7 ERVK-25

6.84e-079461521542922
Pubmed

Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.

ERVK-6 ERVK-8 ERVK-19

1.12e-061261314557543
Pubmed

Phenotypic consequences of variation across the aldosterone synthase and 11-beta hydroxylase locus in a hypertensive cohort: data from the MRC BRIGHT Study.

CYP11B1 CYP11B2

3.03e-06261217651452
Pubmed

Common polymorphisms in the CYP11B1 and CYP11B2 genes: evidence for a digenic influence on hypertension.

CYP11B1 CYP11B2

3.03e-06261223150505
Pubmed

Expression of CYP11B1 and CYP11B2 in adrenal adenoma correlates with clinical characteristics of primary aldosteronism.

CYP11B1 CYP11B2

3.03e-06261234743356
Pubmed

GRAde: a long-read sequencing approach to efficiently identifying the CYP11B1/CYP11B2 chimeric form in patients with glucocorticoid-remediable aldosteronism.

CYP11B1 CYP11B2

3.03e-06261235012455
Pubmed

Role of genetic variation in regulation of aldosterone biosynthesis.

CYP11B1 CYP11B2

3.03e-06261221164264
Pubmed

Polymorphisms in CYP11B2 and CYP11B1 genes associated with primary hyperaldosteronism.

CYP11B1 CYP11B2

3.03e-06261220339375
Pubmed

Genetic analyses of the chimeric CYP11B1/CYP11B2 gene in a Korean family with glucocorticoid-remediable aldosteronism.

CYP11B1 CYP11B2

3.03e-06261220808686
Pubmed

The hamster adrenal cytochrome P450C11 has equipotent 11beta-hydroxylase and 19-hydroxylase activities, but no aldosterone synthase activity.

CYP11B1 CYP11B2

3.03e-0626128645611
Pubmed

Expression and localization of cytochrome P450(11beta,aldo) mRNA in the frog brain.

CYP11B1 CYP11B2

3.03e-06261212231255
Pubmed

A de novo unequal cross-over mutation between CYP11B1 and CYP11B2 genes causes familial hyperaldosteronism type I.

CYP11B1 CYP11B2

3.03e-06261220634641
Pubmed

Hereditary hypertension caused by chimaeric gene duplications and ectopic expression of aldosterone synthase.

CYP11B1 CYP11B2

3.03e-0626121303253
Pubmed

Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets.

CYP11B1 CYP11B2

3.03e-06261221519965
Pubmed

Diagnosis of glucocorticoid-remediable aldosteronism in hypertensive children.

CYP11B1 CYP11B2

3.03e-06261221625068
Pubmed

Genetic screening for glucocorticoid-remediable aldosteronism (GRA): experience of three clinical centres in Poland.

CYP11B1 CYP11B2

3.03e-06261216110193
Pubmed

Chimeric CYP11B2/CYP11B1 causing 11β-hydroxylase deficiency in Chinese patients with congenital adrenal hyperplasia.

CYP11B1 CYP11B2

3.03e-06261226066897
Pubmed

Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.

ERVK-6 ERVK-19

3.03e-0626129060628
Pubmed

Evolutionary relationships within a subgroup of HERV-K-related human endogenous retroviruses.

ERVK-6 ERVK-19

3.03e-0626129460924
Pubmed

Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans.

CYP11B1 CYP11B2

3.03e-0626121741400
Pubmed

Effects of intron conversion in the human CYP11B2 gene on its transcription and blood pressure regulation in transgenic mice.

CYP11B1 CYP11B2

3.03e-06261232540969
Pubmed

Inhibition of aldosterone synthase (CYP11B2) by torasemide prevents atrial fibrosis and atrial fibrillation in mice.

CYP11B1 CYP11B2

3.03e-06261226047574
Pubmed

Aldosterone synthase knockout mouse as a model for sodium-induced endothelial sodium channel up-regulation in vascular endothelium.

CYP11B1 CYP11B2

3.03e-06261226324851
Pubmed

Cytotoxicity and decreased corticosterone production in adrenocortical Y-1 cells by 3-methylsulfonyl-DDE and structurally related molecules.

CYP11B1 CYP11B2

3.03e-06261218651133
Pubmed

Microsatellite polymorphism analysis allows the individual assignment of the rat 11 beta-hydroxylase gene (Cyp11b1) and the rat aldosterone synthase gene (Cyp11b2) to chromosome 7 using rat x mouse somatic cell hybrids and identifies differences between and within various rat strains.

CYP11B1 CYP11B2

3.03e-0626127669222
Pubmed

A new presentation of the chimeric CYP11B1/CYP11B2 gene with low prevalence of primary aldosteronism and atypical gene segregation pattern.

CYP11B1 CYP11B2

3.03e-06261222083159
Pubmed

Aldosterone-dependent and -independent regulation of the epithelial sodium channel (ENaC) in mouse distal nephron.

CYP11B1 CYP11B2

3.03e-06261222933298
Pubmed

Structural and functional analysis of the promoter region of the gene encoding mouse steroid 11 beta-hydroxylase.

CYP11B1 CYP11B2

3.03e-0626122783417
Pubmed

Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism.

CYP11B1 CYP11B2

3.03e-0626122256920
Pubmed

Editorial: polymorphisms in CYP11B genes and 11-hydroxylase activity.

CYP11B1 CYP11B2

3.03e-06261215699546
Pubmed

Cyp11b1 is induced in the murine gonad by luteinizing hormone/human chorionic gonadotropin and involved in the production of 11-ketotestosterone, a major fish androgen: conservation and evolution of the androgen metabolic pathway.

CYP11B1 CYP11B2

3.03e-06261218162527
Pubmed

Chronic activation of adrenal Gq signaling induces Cyp11b2 expression in the zona fasciculata and hyperaldosteronism.

CYP11B1 CYP11B2

3.03e-06261238341019
Pubmed

Association of DNA polymorphisms within the CYP11B2/CYP11B1 locus and postoperative hypertension risk in the patients with aldosterone-producing adenomas.

CYP11B1 CYP11B2

3.03e-06261220708777
Pubmed

Molecular genetic studies on the biosynthesis of aldosterone in humans.

CYP11B1 CYP11B2

3.03e-06261222217843
Pubmed

Mechanistic study of polychlorinated biphenyl 126-induced CYP11B1 and CYP11B2 up-regulation.

CYP11B1 CYP11B2

3.03e-06261216396990
Pubmed

Adrenal CYP11B1/2 expression in primary aldosteronism: immunohistochemical analysis using novel monoclonal antibodies.

CYP11B1 CYP11B2

3.03e-06261224837548
Pubmed

Aldosterone deficiency in mice burdens respiration and accentuates diet-induced hyperinsulinemia and obesity.

CYP11B1 CYP11B2

3.03e-06261230046010
Pubmed

Familial and phenotypic associations of the aldosterone Renin ratio.

CYP11B1 CYP11B2

3.03e-06261219820005
Pubmed

[123 I]Iodometomidate for molecular imaging of adrenocortical cytochrome P450 family 11B enzymes.

CYP11B1 CYP11B2

3.03e-06261218397978
Pubmed

Glucocorticoid-suppressible hyperaldosteronism results from hybrid genes created by unequal crossovers between CYP11B1 and CYP11B2.

CYP11B1 CYP11B2

3.03e-0626121518866
Pubmed

Aldosterone deficiency and mineralocorticoid receptor antagonism prevent angiotensin II-induced cardiac, renal, and vascular injury.

CYP11B1 CYP11B2

3.03e-06261222622494
Pubmed

Mutation analysis of CYP11B1 and CYP11B2 in patients with increased 18-hydroxycortisol production.

CYP11B1 CYP11B2

3.03e-06261215062555
Pubmed

Procollagen I-expressing renin cell precursors.

CYP11B1 CYP11B2

3.03e-06261223761669
Pubmed

Disturbed homeostasis in sodium-restricted mice heterozygous and homozygous for aldosterone synthase gene disruption.

CYP11B1 CYP11B2

3.03e-06261217075030
Pubmed

Polymorphic variation in the 11beta-hydroxylase gene associates with reduced 11-hydroxylase efficiency.

CYP11B1 CYP11B2

3.03e-06261217075029
Pubmed

Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).

CYP11B1 CYP11B2

3.03e-0626122592361
Pubmed

CYP11B2-CYP11B1 haplotypes associated with decreased 11 beta-hydroxylase activity.

CYP11B1 CYP11B2

3.03e-06261215507509
Pubmed

Polymorphism of CYP11B2 determines salt sensitivity in Japanese.

CYP11B1 CYP11B2

3.03e-06261217296872
Pubmed

Aldosterone deficiency prevents high-fat-feeding-induced hyperglycaemia and adipocyte dysfunction in mice.

CYP11B1 CYP11B2

3.03e-06261223314847
Pubmed

Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects.

CYP11B1 CYP11B2

3.03e-06261217980006
Pubmed

Association between aldosterone production and variation in the 11beta-hydroxylase (CYP11B1) gene.

CYP11B1 CYP11B2

3.03e-06261216984984
Pubmed

Evidence for local aldosterone synthesis in the large intestine of the mouse.

CYP11B1 CYP11B2

3.03e-06261235288482
Pubmed

Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice.

CYP11B1 CYP11B2

3.03e-06261215731365
Pubmed

Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase.

CYP11B1 CYP11B2

3.03e-06261218039983
Pubmed

Cyp11b1 null mouse, a model of congenital adrenal hyperplasia.

CYP11B1 CYP11B2

3.03e-06261219029289
Pubmed

Genetic variation at the locus encompassing 11-beta hydroxylase and aldosterone synthase accounts for heritability in cortisol precursor (11-deoxycortisol) urinary metabolite excretion.

CYP11B1 CYP11B2

3.03e-06261215522937
Pubmed

The FERM protein Epb4.1l5 is required for organization of the neural plate and for the epithelial-mesenchymal transition at the primitive streak of the mouse embryo.

MYH10 RDX MSN

4.88e-061961317507402
Pubmed

Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation.

MYH10 RDX MSN

7.72e-062261327870829
Pubmed

The ezrin-like family of tyrosine kinase substrates: receptor-specific pattern of tyrosine phosphorylation and relationship to malignant transformation.

RDX MSN

9.07e-0636128479753
Pubmed

Immune escape of colorectal tumours via local LRH-1/Cyp11b1-mediated synthesis of immunosuppressive glucocorticoids.

CYP11B1 CYP11B2

9.07e-06361236861295
Pubmed

Characterization of lens fiber cell triton insoluble fraction reveals ERM (ezrin, radixin, moesin) proteins as major cytoskeletal-associated proteins.

RDX MSN

9.07e-06361218261459
Pubmed

Ezrin, radixin, and moesin are phosphorylated in response to 2-methoxyestradiol and modulate endothelial hyperpermeability.

RDX MSN

9.07e-06361221659656
Pubmed

Expression, localization, and binding activity of the ezrin/radixin/moesin proteins in the mouse testis.

RDX MSN

9.07e-06361219064715
Pubmed

Activation of PKC induces leukocyte adhesion by the dephosphorylation of ERM.

RDX MSN

9.07e-06361231843195
Pubmed

Adrenal-Specific KO of the Circadian Clock Protein BMAL1 Alters Blood Pressure Rhythm and Timing of Eating Behavior.

CYP11B1 CYP11B2

9.07e-06361236778748
Pubmed

Differential involvement of ezrin/radixin/moesin proteins in sphingosine 1-phosphate-induced human pulmonary endothelial cell barrier enhancement.

RDX MSN

9.07e-06361221864676
Pubmed

Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain.

CYP11B1 CYP11B2

9.07e-0636128111631
Pubmed

The roles of cAMP and cAMP-dependent protein kinase in the expression of cholesterol side chain cleavage and steroid 11 beta-hydroxylase genes in mouse adrenocortical tumor cells.

CYP11B1 CYP11B2

9.07e-0636122546938
Pubmed

Kidney function in mice lacking aldosterone.

CYP11B1 CYP11B2

9.07e-06361216118390
Pubmed

Differential expression of ezrin/radixin/moesin (ERM) and ERM-associated adhesion molecules in the blastocyst and uterus suggests their functions during implantation.

RDX MSN

9.07e-06361214613898
Pubmed

Increased phosphorylation of ezrin/radixin/moesin proteins contributes to proliferation of rheumatoid fibroblast-like synoviocytes.

RDX MSN

9.07e-06361221278069
Pubmed

Inhibition of cell adhesion by phosphorylated Ezrin/Radixin/Moesin.

RDX MSN

9.07e-06361226555866
Pubmed

Interaction of CYP11B1 (cytochrome P-45011 beta) with CYP11A1 (cytochrome P-450scc) in COS-1 cells.

CYP11B1 CYP11B2

9.07e-06361210411633
Pubmed

Differential effects of high and low steroidogenic factor-1 expression on CYP11B2 expression and aldosterone production in adrenocortical cells.

CYP11B1 CYP11B2

9.07e-06361218974272
Pubmed

Aldosterone-induced coronary dysfunction in transgenic mice involves the calcium-activated potassium (BKCa) channels of vascular smooth muscle cells.

CYP11B1 CYP11B2

9.07e-06361217984374
Pubmed

Human ezrin-moesin-radixin proteins modulate hepatitis C virus infection.

RDX MSN

9.07e-06361223703860
Pubmed

Different isozymes of mouse 11 beta-hydroxylase produce mineralocorticoids and glucocorticoids.

CYP11B1 CYP11B2

9.07e-0636121686470
Pubmed

Pseudomonas aeruginosa ExoS ADP-ribosyltransferase inhibits ERM phosphorylation.

RDX MSN

9.07e-06361216889625
Pubmed

Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.

ERVK-6 ERVK-19

9.07e-06361210516026
Pubmed

Identification and characterization of two upstream elements that regulate adrenocortical expression of steroid 11 beta-hydroxylase.

CYP11B1 CYP11B2

9.07e-0636122233742
Pubmed

Substrate-induced modulation of protein-protein interactions within human mitochondrial cytochrome P450-dependent system.

CYP11B1 CYP11B2

9.07e-06361233271253
Pubmed

Mislocalization of protein kinase A drives pathology in Cushing's syndrome.

CYP11B1 CYP11B2

9.07e-06361235830806
Pubmed

Nuclear ERM (ezrin, radixin, moesin) proteins: regulation by cell density and nuclear import.

RDX MSN

9.07e-06361215149851
Pubmed

The prolactin regulatory element-binding regulates of the 11beta-hydroxylase gene.

CYP11B1 CYP11B2

9.07e-06361218801336
Pubmed

Differential regulation of aldosterone synthase and 11beta-hydroxylase transcription by steroidogenic factor-1.

CYP11B1 CYP11B2

9.07e-06361211932209
Pubmed

Effect of knockdown of ezrin, radixin, and moesin on P-glycoprotein function in HepG2 cells.

RDX MSN

9.07e-06361221837648
Pubmed

ERM stable knockdown by siRNA reduced in vitro migration and invasion of human SGC-7901 cells.

RDX MSN

9.07e-06361221352885
Pubmed

Ezrin and moesin function together to promote T cell activation.

RDX MSN

9.07e-06361219124745
Pubmed

A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites.

RDX MSN

9.07e-0636121429901
Pubmed

ERM Proteins at the Crossroad of Leukocyte Polarization, Migration and Intercellular Adhesion.

RDX MSN

9.07e-06361232098334
Pubmed

Ezrin, Radixin, and Moesin (ERM) proteins function as pleiotropic regulators of human immunodeficiency virus type 1 infection.

RDX MSN

9.07e-06361218295815
Pubmed

Aldosterone postnatally, but not at birth, is required for optimal induction of renal mineralocorticoid receptor expression and sodium reabsorption.

CYP11B1 CYP11B2

9.07e-06361221467193
Pubmed

Dmoesin controls actin-based cell shape and polarity during Drosophila melanogaster oogenesis.

RDX MSN

9.07e-06361212360288
Pubmed

Activation of Ras requires the ERM-dependent link of actin to the plasma membrane.

RDX MSN

9.07e-06361222132106
Pubmed

Dynamics and function of ERM proteins during cytokinesis in human cells.

RDX MSN

9.07e-06361228889652
Pubmed

Control of adipogenesis by ezrin, radixin and moesin-dependent biomechanics remodeling.

RDX MSN

9.07e-06361223116763
Pubmed

Control of renin secretion from kidneys with renin cell hyperplasia.

CYP11B1 CYP11B2

9.07e-06361224285498
Pubmed

Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis.

CYP11B1 CYP11B2

9.07e-0636127750493
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

FRMD4A PTPN13 RDX MSN

2.00e-06503341293
GeneFamilyCytochrome P450 family 11

CYP11B1 CYP11B2

9.68e-0633321007
GeneFamilyPyrin domain containing|Pyrin and HIN domain family

NLRP12 NLRP9

9.44e-0425332994
GeneFamilyNLR family

NLRP12 NLRP9

9.44e-0425332666
GeneFamilyRho GTPase activating proteins|BCH domain containing

STARD13 TAGAP

3.75e-0350332721
ToppCellP15-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

STARD13 DPY19L3 SREBF1 RMND1 PDE10A

2.81e-06176565792f414f5092aba14260b8e16378e793a822498e
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P1-P1_2-Tnr-Polydendrocye.Tnr.Pdgfa_(Pdgfa)|Striatum / BrainAtlas - Mouse McCarroll V32

FRMD4A IKBKE PKD1L1 TAS1R1

7.13e-069856426250ea4171a0557a67505839cf79d3fe4d9d41a
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P1-P1_2-Tnr|Striatum / BrainAtlas - Mouse McCarroll V32

FRMD4A IKBKE PKD1L1 TAS1R1

7.13e-069856442875d16ae9fcbaf988cd71be82568f2f862f2dd
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P1-P1_2|Striatum / BrainAtlas - Mouse McCarroll V32

FRMD4A IKBKE PKD1L1 TAS1R1

7.13e-06985647a62a77ca83153dacff4d02d6e32104227d0980d
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PLCD3 IGSF10 RMND1 DNAH7

3.52e-05147564f5109e0f4e8b46a977a763c9c72a2df9840e3977
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PLCD3 IGSF10 RMND1 DNAH7

3.52e-05147564ad0c575bc9c5f201f2a7810452e8b3f741e65d89
ToppCellnormal_Pleural_Fluid-B_lymphocytes-Plasma_cells|B_lymphocytes / Location, Cell class and cell subclass

DPY19L3 NICN1 CCDC157 EFR3A

4.12e-05153564a156710217ef07c07a80ca6504fa0784d86380fa
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PLCD3 TTC13 TRAK2 CCDC157

6.49e-05172564d65ffff3e341af34a043a0d802d7ba4b69de36e9
ToppCell10x_5'_v1-Neoplastic-Stem-like-OPC-like|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

IGSF10 NLRP12 MYH10 COBL

6.94e-05175564cc596907ea1a64ab7b5a8c7d4ad12e6ee59bfed9
ToppCell10x_5'_v1-Neoplastic-Stem-like|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

IGSF10 NLRP12 MYH10 COBL

6.94e-05175564a8400e7e47379901dcab5f2e364c3ff17765b4b9
ToppCell10x_5'_v1-Neoplastic-Stem-like-OPC-like-OPC-like|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

IGSF10 NLRP12 MYH10 COBL

6.94e-051755648a3abf40146ae3459d97cdf865c1c8f6b92ac639
ToppCell10x_5'_v1-Neoplastic-Stem-like-OPC-like-OPC-like-Z|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

IGSF10 NLRP12 MYH10 COBL

6.94e-05175564378d2b79edac91fc74eee0fb42bb29dd9b07c36f
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

STARD13 FRY MYH10 PTPN13

8.25e-05183564b5ede5a0048c585b73c00e88aeddbcaf669347b1
ToppCellPND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_prolif|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FRY EGLN1 MERTK CCDC157

8.25e-051835643ef9ac1ae13b6172f9121ab1c129ecaa0fef460f
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

STARD13 FRY MYH10 PTPN13

8.96e-05187564f6217d0dd425eac76900b44a4e48f45475f3ac36
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STARD13 FRY MYH10 PTPN13

8.96e-05187564e3095455d2f255854f339f6b05fa87852af0700f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STARD13 FRY MYH10 PTPN13

9.15e-05188564e30a4ddac0da8cdcf621d98e28e3895cd9307e7a
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STARD13 FRY MYH10 PTPN13

9.34e-051895643a295c215b5c18e7c673f92b7af5be523421682c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

STARD13 FRY MYH10 PTPN13

9.53e-05190564b7f8c2bb9459f1d7c1690069dd5a25a81a57cc84
ToppCellLPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FRMD4A MYH10 KIAA1755 PDE10A

9.53e-0519056445df8fee00f8949937863159d7aa042e72748d9b
ToppCellLPS_only-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FRMD4A MYH10 PTPN13 KIAA1755

9.92e-05192564df1545670370fb1010c567cd059c2783eab315f7
ToppCellCOVID-19-kidney-CD-PC|kidney / Disease (COVID-19 only), tissue and cell type

FRY MYH10 PTPN13 PDE10A

1.01e-04193564738689d009e4b118d7ce3171a207294b95cbe78b
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)|390C / Donor, Lineage, Cell class and subclass (all cells)

DAB2IP RDX TRAK2 MERTK

1.03e-0419456488db9f9e80c20ff3474f1f6459dcbdc25aec0b6d
ToppCellLPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IGSF10 MYH10 KIAA1755 PDE10A

1.03e-0419456489b706af2b25991fc2707eb24f49ba6ff3ae01f7
ToppCell390C-Epithelial_cells-Epithelial-I_(AT1)-|390C / Donor, Lineage, Cell class and subclass (all cells)

DAB2IP RDX TRAK2 MERTK

1.03e-04194564a71728202493d4858342ea2756ea281cd0d99a3a
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

STARD13 FRMD4A NFKBID MERTK

1.03e-0419456445708cb2cafde10bf4e4798b81d47c3b1f6aaa14
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

STARD13 FRMD4A NFKBID MERTK

1.05e-04195564247803cf58c6d9c561a52aa34e581188ddad197e
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FRMD4A TAGAP NFKBID MERTK

1.05e-04195564562e4c0e4e81f6303e57b846da71d1667fc35963
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FRMD4A TAGAP NFKBID MERTK

1.05e-04195564fa8ac154e5aebc26463ff84f0ad1038095770bc6
ToppCellLPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

IGSF10 FRMD4A MYH10 KIAA1755

1.14e-041995648b86c69aaf60feff53aa782559cfece7342a23de
Drugcyadox

CYP11B1 CYP11B2

6.16e-062572ctd:C020728
Drug18-hydroxydeoxycorticosterone

CYP11B1 CYP11B2

6.16e-062572ctd:C042509
Drug18-hydroxycortisol

CYP11B1 CYP11B2

1.84e-053572ctd:C033689
Diseaseadrenal cortical adenoma (is_marker_for)

CYP11B1 CYP11B2

3.29e-062542DOID:0050891 (is_marker_for)
DiseaseGlucocorticoid-remediable aldosteronism

CYP11B1 CYP11B2

3.29e-062542C1260386
Diseasethrombopoietin receptor measurement

NLRP12 DPY19L3

9.85e-063542EFO_0020769
Diseasecongenital adrenal hyperplasia (implicated_via_orthology)

CYP11B1 CYP11B2

9.85e-063542DOID:0050811 (implicated_via_orthology)
Diseaseprimary hyperaldosteronism (is_implicated_in)

CYP11B1 CYP11B2

3.28e-055542DOID:446 (is_implicated_in)
Diseaseprogrammed cell death protein 5 measurement

NLRP12 DPY19L3

3.28e-055542EFO_0801927
DiseaseConn Syndrome

CYP11B1 CYP11B2

4.91e-056542C1384514
DiseaseHyperaldosteronism

CYP11B1 CYP11B2

4.91e-056542C0020428
Diseaseprotocadherin alpha-7 measurement

CYP11B1 CYP11B2

6.86e-057542EFO_0801973
Diseasehepatitis C virus infection, cirrhosis of liver

PKD1L1 MERTK

6.86e-057542EFO_0001422, EFO_0003047
Diseaseprotein FAM163B measurement

CYP11B1 CYP11B2

1.17e-049542EFO_0802936
Diseaseandrostenedione measurement

CYP11B1 CYP11B2

1.47e-0410542EFO_0007972
Disease3-hydroxyanthranilate 3,4-dioxygenase measurement

CYP11B1 CYP11B2

1.79e-0411542EFO_0021862
Diseasecell growth regulator with EF hand domain protein 1 measurement

CYP11B1 CYP11B2

1.79e-0411542EFO_0801461
DiseasePulmonary Thromboembolisms

DAB2IP MERTK

2.14e-0412542C0524702
DiseasePulmonary Embolism

DAB2IP MERTK

2.14e-0412542C0034065
Diseasebehavioural inhibitory control measurement

PDE10A EFR3A

3.88e-0416542EFO_0008467
Diseasevision disorder

MYH10 RDX

3.88e-0416542MONDO_0021084
Diseaseglioma

NICN1 D2HGDH

7.42e-0422542EFO_0005543
DiseaseHereditary Paraganglioma-Pheochromocytoma Syndrome

EGLN1 MERTK

8.11e-0423542C1708353
Diseaseapolipoprotein L1 measurement

CYP11B1 CYP11B2

9.60e-0425542EFO_0021854
DiseaseBeta blocking agent use measurement

CYP11B2 PDE10A ZNF831

1.21e-03114543EFO_0009929
Diseasebrain infarction (biomarker_via_orthology)

CYP11B1 CYP11B2

1.67e-0333542DOID:3454 (biomarker_via_orthology)
Diseasehypertension (implicated_via_orthology)

CYP11B1 CYP11B2 EGLN1

1.68e-03128543DOID:10763 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
MGDRLMSLEHRFQLQ

ERVK-19

536

O71037
MGDRLMSLEHRFQLQ

ERVK-8

536

Q902F8
LVRQCNEGAHRMERM

ARHGEF16

461

Q5VV41
CRLRDLLDIANGHMM

DPY19L3

651

Q6ZPD9
MAHLLGSQACMESLR

CCDC157

1

Q569K6
LMGRMEIEACLGSLH

CDAN1

1166

Q8IWY9
EDNLPMFHRCGIMAL

EFR3A

586

Q14156
LHCQERANELMRAMK

RFX4

471

Q33E94
CRRLVEDGMHALGAM

MON1B

366

Q7L1V2
LALCMGNHELYMRRR

RDX

281

P35241
MDMLLGLDMLRRHQC

DDI1

326

Q8WTU0
LMMSEVDRCGDNEHL

DAB2IP

396

Q5VWQ8
MQELDMLAGLRRSHA

KCND1

556

Q9NSA2
HRDLAARNCMLRDDM

MERTK

721

Q12866
QARDRLDCVHMLLQM

NFKBID

181

Q8NI38
FHMDCQDLMAQLRLD

KIAA1755

971

Q5JYT7
RKDLLLHMQELCEGM

IKBKE

676

Q14164
MLEHGGLMRDVNRRL

CCDC85C

46

A6NKD9
DLGNMHRANVIRLMD

MTIF3

96

Q9H2K0
HRDRVIGLMMTACDL

PDE10A

651

Q9Y233
LALCMGNHELYMRRR

MSN

281

P26038
GMLMDGLKELNLHRC

ENPP1

401

P22413
MGDRLMSLEHRFQLQ

ERVK-7

1296

P63135
MLLRMSEHRNEALGN

HCP5

1

Q6MZN7
RERKRMHDLNLAMDG

OLIG3

91

Q7RTU3
LGLLMMTEGRRCQVH

FRMD4A

11

Q9P2Q2
CVARNKMGDDLILMH

IGSF10

2016

Q6WRI0
GMMLLSDAHQCRRLY

KLHL25

151

Q9H0H3
MGDRLMSLEHRFQLQ

ERVK-25

536

P61570
MGDRLMSLEHRFQLQ

ERVK-6

536

Q69384
RHCLGEHLARMEMFL

CYP2R1

446

Q6VVX0
GSHAMMDLLVELCLQ

COBL

81

O75128
LGMFEMHCEELIRAL

DNAH7

546

Q8WXX0
GMRQCLGRRLAEAEM

CYP11B1

446

P15538
LLMSSMDDLIRHCNG

EGLN1

271

Q9GZT9
GMRQCLGRRLAEAEM

CYP11B2

446

P19099
MGDRLMSLEHRFQLQ

HERVK_113

536

Q902F9
ILRHLDKEVGRCMML

FRY

566

Q5TBA9
HRGLCRAFMDLTLMA

PKD1L1

2591

Q8TDX9
DMRQGRTLLHCMAGV

DUSP21

96

Q9H596
LCHLLGMNVMEFTRA

MYH10

381

P35580
EFMDAVCMQLVGRHL

D2HGDH

311

Q8N465
RNCMSMGALKDLLRH

PRAMEF13

386

Q5VWM6
ISDLVRCMRLQRHGM

PTPN13

2436

Q12923
GLAHMIMECDRLFEV

STARD13

856

Q9Y3M8
GSMRARMLEAHCLLP

TAGAP

621

Q8N103
RRLHGMDMSVLLEQD

RBL1

481

P28749
KHQMLCDMARISELR

NICN1

101

Q9BSH3
LQHCMELTDLMRNHL

RMND1

406

Q9NWS8
RLLHDCQQMLMRLGG

SREBF1

1126

P36956
MRLLQRRGDCFAFMH

NLRP9

431

Q7RTR0
RDARMRLMKHDVNLG

PRPF8

1136

Q6P2Q9
IACLMDMNALLDRFH

TMEM240

21

Q5SV17
LHELQDRNMECLGML

TRAK2

326

O60296
RIHRAMGLAALEVMQ

TTC13

526

Q8NBP0
VGDERMQCLMRHLAQ

TAS1R1

251

Q7RTX1
AMARHLCTILGDMLV

PLCD3

441

Q8N3E9
CGARMMRRLLAQHAT

TRAF4

171

Q9BUZ4
GMLALEMLGRRAHND

ZSWIM8

1671

A7E2V4
QDMEGDSHRIHRLCM

ZNF831

1066

Q5JPB2
RELSMECGLNNRIRM

TSC2

46

P49815
GMMLLCEGLRHPQCR

NLRP12

786

P59046