Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone phosphatase activity

EYA1 EYA2 EYA3

4.95e-0731593GO:0140789
GeneOntologyMolecularFunctionhistone H2AXY142 phosphatase activity

EYA1 EYA2 EYA3

4.95e-0731593GO:0140793
GeneOntologyMolecularFunctiontranscription coregulator activity

BIRC2 CCND1 PPP1R13L PARP14 DDX1 BCLAF3 YEATS2 ANKRD1 SUPT7L KDM2B MED17 SDR16C5 HSPA1A HSPA1B DNMT3A

4.47e-0556215915GO:0003712
GeneOntologyMolecularFunctionchemokine activity

CCL28 CCL2 CCL7 CCL13 CX3CL1

5.25e-05511595GO:0008009
GeneOntologyMolecularFunctiontranscription corepressor activity

CCND1 PPP1R13L PARP14 YEATS2 ANKRD1 SDR16C5 HSPA1A HSPA1B DNMT3A

9.41e-052291599GO:0003714
GeneOntologyMolecularFunctiondenatured protein binding

HSPA1A HSPA1B

1.88e-0431592GO:0031249
GeneOntologyMolecularFunction5-methylcytosine dioxygenase activity

TET2 TET3

1.88e-0431592GO:0070579
GeneOntologyMolecularFunctionmisfolded protein binding

SDF2L1 HSPA1A HSPA1B

3.70e-04181593GO:0051787
GeneOntologyMolecularFunctionchemokine receptor binding

CCL28 CCL2 CCL7 CCL13 CX3CL1

4.73e-04811595GO:0042379
GeneOntologyMolecularFunctionalpha-amylase activity

AMY2A AMY2B

6.20e-0451592GO:0004556
GeneOntologyMolecularFunctiondeath receptor agonist activity

HSPA1A HSPA1B

6.20e-0451592GO:0038177
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

KLHDC2 BIRC2 CCND1 PPP1R13L PARP14 DDX1 FAN1 BCLAF3 YEATS2 RPTOR ANKRD1 SUPT7L SUN5 KDM2B MED17 SDR16C5 HSPA1A HSPA1B HOMER2 DNMT3A

9.25e-04116015920GO:0030674
GeneOntologyMolecularFunctionamylase activity

AMY2A AMY2B

9.25e-0461592GO:0016160
GeneOntologyMolecularFunctionATP-dependent protein disaggregase activity

HSPA1A HSPA1B

9.25e-0461592GO:0140545
GeneOntologyMolecularFunctionC3HC4-type RING finger domain binding

HSPA1A HSPA1B

9.25e-0461592GO:0055131
GeneOntologyMolecularFunctionCCR chemokine receptor binding

CCL2 CCL7 CCL13 CX3CL1

1.03e-03561594GO:0048020
GeneOntologyBiologicalProcessnegative regulation of signal transduction in absence of ligand

EYA4 EYA1 EYA2 EYA3 HSPA1A CX3CL1 HSPA1B

2.13e-08401597GO:1901099
GeneOntologyBiologicalProcessnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand

EYA4 EYA1 EYA2 EYA3 HSPA1A CX3CL1 HSPA1B

2.13e-08401597GO:2001240
GeneOntologyBiologicalProcessregulation of extrinsic apoptotic signaling pathway in absence of ligand

EYA4 EYA1 EYA2 EYA3 HSPA1A CX3CL1 HSPA1B

1.85e-07541597GO:2001239
GeneOntologyBiologicalProcessextrinsic apoptotic signaling pathway in absence of ligand

ERBB3 EYA4 EYA1 EYA2 EYA3 HSPA1A CX3CL1 HSPA1B

2.30e-07821598GO:0097192
GeneOntologyBiologicalProcesssignal transduction in absence of ligand

ERBB3 EYA4 EYA1 EYA2 EYA3 HSPA1A CX3CL1 HSPA1B

2.77e-07841598GO:0038034
GeneOntologyBiologicalProcessnegative regulation of extrinsic apoptotic signaling pathway

EYA4 EYA1 EYA2 EYA3 SCG2 HSPA1A CX3CL1 HSPA1B

2.70e-061131598GO:2001237
GeneOntologyBiologicalProcesseosinophil chemotaxis

SCG2 CCL2 CCL7 CCL13 CX3CL1

3.12e-06301595GO:0048245
GeneOntologyBiologicalProcessregulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway

BIRC2 BIRC3 HSPA1A HSPA1B

5.76e-06161594GO:0070424
GeneOntologyBiologicalProcesseosinophil migration

SCG2 CCL2 CCL7 CCL13 CX3CL1

5.94e-06341595GO:0072677
GeneOntologyBiologicalProcessnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway

BIRC2 BIRC3 HSPA1A HSPA1B

7.97e-05301594GO:0035872
GeneOntologyBiologicalProcessregulation of extrinsic apoptotic signaling pathway

EYA4 EYA1 EYA2 EYA3 SCG2 HSPA1A CX3CL1 HSPA1B

8.27e-051811598GO:2001236
GeneOntologyBiologicalProcesscellular response to tumor necrosis factor

BIRC2 BIRC3 IRF1 ANKRD1 CCL2 HSPA1A CX3CL1 HSPA1B COL1A1

8.41e-052331599GO:0071356
GeneOntologyBiologicalProcessnegative regulation of apoptotic process

ERBB3 EYA4 BIRC2 BIRC3 CCND1 EYA1 EYA2 EYA3 ADNP NDUFAF4 MTOR SCG2 AIPL1 PRAP1 KDM2B NLE1 CCL2 HSPA1A CX3CL1 HSPA1B PCID2

1.71e-04113315921GO:0043066
GeneOntologyBiologicalProcesscardiac muscle thin filament assembly

NRAP NEB

1.76e-0431592GO:0071691
GeneOntologyBiologicalProcesspost-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery

NUP107 PCID2

1.76e-0431592GO:0000973
GeneOntologyBiologicalProcessorganelle assembly

SPAG1 SNX4 NRAP IFT172 SPEF2 CEP192 POGZ NEB CSMD2 PIK3C3 MTOR CFAP221 ANKRD1 NLE1 TNKS DIAPH3 HPS5 HSPA1A HSPA1B DNAH8 VPS13B

1.81e-04113815921GO:0070925
GeneOntologyBiologicalProcessresponse to tumor necrosis factor

BIRC2 BIRC3 IRF1 ANKRD1 CCL2 HSPA1A CX3CL1 HSPA1B COL1A1

1.82e-042581599GO:0034612
GeneOntologyBiologicalProcessextrinsic apoptotic signaling pathway

ERBB3 EYA4 EYA1 EYA2 EYA3 SCG2 HSPA1A CX3CL1 HSPA1B

1.87e-042591599GO:0097191
GeneOntologyBiologicalProcesspositive regulation of Wnt signaling pathway

USP34 LRRK1 ADNP NLE1 MLLT3 TNKS COL1A1

2.28e-041581597GO:0030177
GeneOntologyBiologicalProcessepithelial cell proliferation

FLT1 NOX5 IFT172 CCND1 EYA1 CASK MTOR RPTOR SCG2 CCL2 CCL13 SDR16C5 IQGAP3 TBX2

2.46e-0460315914GO:0050673
GeneOntologyBiologicalProcessnegative regulation of programmed cell death

ERBB3 EYA4 BIRC2 BIRC3 CCND1 EYA1 EYA2 EYA3 ADNP NDUFAF4 MTOR SCG2 AIPL1 PRAP1 KDM2B NLE1 CCL2 HSPA1A CX3CL1 HSPA1B PCID2

2.67e-04117115921GO:0043069
GeneOntologyBiologicalProcesspositive regulation of pentose-phosphate shunt

MTOR RPTOR

3.51e-0441592GO:1905857
GeneOntologyBiologicalProcessresponse to heat

SCN11A TRPM2 EEF1D MTOR HSPA1A HSPA1B

3.54e-041211596GO:0009408
GeneOntologyBiologicalProcesspositive regulation of canonical Wnt signaling pathway

USP34 LRRK1 ADNP NLE1 TNKS COL1A1

3.54e-041211596GO:0090263
GeneOntologyBiologicalProcessfatty acid beta-oxidation

ACOX1 MLYCD MFSD2A MTOR PEX5

3.86e-04801595GO:0006635
GeneOntologyBiologicalProcessnegative regulation of apoptotic signaling pathway

EYA4 EYA1 EYA2 EYA3 SCG2 NLE1 HSPA1A CX3CL1 HSPA1B

3.88e-042861599GO:2001234
GeneOntologyBiologicalProcessembryonic camera-type eye development

IFT172 PPP1R13L KDM2B TBX2

3.96e-04451594GO:0031076
DomainEYA_dom

EYA4 EYA1 EYA2 EYA3

4.68e-0941564IPR006545
DomainEYA_fam

EYA4 EYA1 EYA2 EYA3

4.68e-0941564IPR028472
DomainCX3CL1

CCL2 CCL13 CX3CL1

2.27e-0641563IPR008097
DomainSCY

CCL28 CCL2 CCL7 CCL13 CX3CL1

2.53e-05421565SM00199
DomainChemokine_IL8-like_dom

CCL28 CCL2 CCL7 CCL13 CX3CL1

3.18e-05441565IPR001811
DomainIL8

CCL28 CCL2 CCL7 CCL13 CX3CL1

3.18e-05441565PF00048
DomainSMALL_CYTOKINES_CC

CCL28 CCL2 CCL7 CCL13

6.07e-05261564PS00472
DomainChemokine_CC_CS

CCL28 CCL2 CCL7 CCL13

6.07e-05261564IPR000827
DomainA-amylase_C

AMY2A AMY2B

2.07e-0431562IPR031319
DomainNebulin

NRAP NEB

4.11e-0441562PF00880
DomainAlpha_amylase

AMY2A AMY2B

4.11e-0441562IPR006046
DomainYEATS

YEATS2 MLLT3

4.11e-0441562PS51037
DomainNEBULIN

NRAP NEB

4.11e-0441562PS51216
DomainNEBU

NRAP NEB

4.11e-0441562SM00227
DomainNebulin

NRAP NEB

4.11e-0441562IPR013998
DomainAamy_C

AMY2A AMY2B

4.11e-0441562SM00632
DomainYEATS

YEATS2 MLLT3

4.11e-0441562IPR005033
DomainNebulin_repeat

NRAP NEB

4.11e-0441562IPR000900
DomainYEATS

YEATS2 MLLT3

4.11e-0441562PF03366
DomainARM-type_fold

USP34 IFT172 TOGARAM2 RYR3 PIK3C3 MTOR RPTOR MROH2B DIAPH3 ARMC8

5.74e-0433915610IPR016024
DomainAlpha-amylase_C

AMY2A AMY2B

6.82e-0451562PF02806
DomainA-amylase/branching_C

AMY2A AMY2B

6.82e-0451562IPR006048
PathwayREACTOME_HSF1_DEPENDENT_TRANSACTIVATION

MTOR RPTOR HSPA1A HSPA1B

2.87e-05231114MM14953
PathwayREACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES

CCL28 CCL2 CCL7 CCL13 CX3CL1

8.36e-05571115M625
PathwayKEGG_MEDICUS_PATHOGEN_HSV_GD_TO_HVEM_NFKB_SIGNALING_PATHWAY

BIRC2 BIRC3 CCL2

9.93e-05121113M47600
PathwayKEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY

BIRC2 BIRC3 CCL2 CCL7 CCL13

1.25e-04621115M15569
Pubmed

EYA4, a novel vertebrate gene related to Drosophila eyes absent.

EYA4 EYA1 EYA2 EYA3

6.42e-09616049887327
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

TET2 USP34 EPRS1 DMXL2 ERBB3 TTC28 MYCBP2 IFT172 ABCC5 BIRC2 POGZ EYA3 CPNE5 RYR3 FAN1 CASK COG1 SCG2 MLLT3 TNKS HSPA1A HSPA1B ARMC8

2.70e-0812851602335914814
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

TET2 USP34 NUP107 TTC28 MYCBP2 POGZ ADNP YEATS2 N4BP2 KDM2B DIAPH3 HSPA1A HSPA1B

8.06e-084181601334709266
Pubmed

A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family.

EYA1 EYA2 EYA3

9.56e-08316039020840
Pubmed

Loss of cIAP1 attenuates soleus muscle pathology and improves diaphragm function in mdx mice.

BIRC2 BIRC3 DMD

9.56e-083160323184147
Pubmed

Eyes absent represents a class of protein tyrosine phosphatases.

EYA1 EYA2 EYA3

9.56e-083160314628052
Pubmed

Misexpression of the eyes absent family triggers the apoptotic program.

EYA1 EYA2 EYA3

3.81e-074160311700312
Pubmed

Chemokine expression by small sputum macrophages in COPD.

CCL2 CCL7 CCL13

3.81e-074160321327296
Pubmed

TET2 catalyzes active DNA demethylation of the Sry promoter and enhances its expression.

TET2 SRY TET3 DNMT3A

5.66e-0715160431530896
Pubmed

Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx.

CCL2 CCL7 CCL13

9.49e-075160318660381
Pubmed

Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and nasal placode.

EYA1 EYA2 EYA3

9.49e-07516039006082
Pubmed

Identification of new regulatory sequences far upstream of the mouse monocyte chemoattractant protein-1 gene.

CCL2 CCL7 CCL13

9.49e-075160311735217
Pubmed

Inflammatory Monocytes Promote Perineural Invasion via CCL2-Mediated Recruitment and Cathepsin B Expression.

CCL2 CCL7 CTSS

9.49e-075160328951461
Pubmed

Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya.

EYA1 EYA2 EYA3

9.49e-075160310490620
Pubmed

Eyes absent: a gene family found in several metazoan phyla.

EYA1 EYA2 EYA3

9.49e-07516039195991
Pubmed

Large-scale genotyping identifies 41 new loci associated with breast cancer risk.

TET2 N4BP2L1 ADAM29 CHST9 NTN4 DNAJC1

1.45e-0676160623535729
Pubmed

CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines.

CCL2 CCL7 CCL13

1.89e-066160310734104
Pubmed

Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1.

CCL2 CCL7 CCL13

1.89e-06616038996246
Pubmed

Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways.

CCL2 CCL7 CCL13

1.89e-066160310072545
Pubmed

A CCL8 gradient drives breast cancer cell dissemination.

CCL2 CCL7 CCL13

1.89e-066160327181207
Pubmed

Chemokine/chemokine receptor nomenclature.

CCL28 CCL2 CCL7 CCL13 CX3CL1

2.82e-0648160512080938
Pubmed

IL-2-induced proliferative response is controlled by loci Cinda1 and Cinda2 on mouse chromosomes 11 and 12: a distinct control of the response induced by different IL-2 concentrations.

IRF1 CCL2 CCL7 CCL13

2.96e-062216049177770
Pubmed

ER-associated degradation preserves hematopoietic stem cell quiescence and self-renewal by restricting mTOR activity.

MTOR RPTOR COL1A1

3.30e-067160333150381
Pubmed

A distinct chemokine axis does not account for enrichment of Foxp3(+)  CD4(+) T cells in carcinogen-induced fibrosarcomas.

CCL2 CCL7 CX3CL1

3.30e-067160325495686
Pubmed

P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration.

PREX2 MTOR RPTOR

3.30e-067160317565979
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

USP34 NUP107 TTC28 ARHGAP17 CEP192 EYA3 DDX1 YEATS2 N4BP2 RPTOR MCM3AP KDM2B DIAPH3

3.68e-065881601338580884
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

GTPBP4 DMXL2 NUP107 MYCBP2 FAM98A CEP192 CASK FAM204A ESYT2 NDUFAF4 THEM4 N4BP2 TOMM34 SDF2L1 NLE1 DNAJC1 DIAPH3 PARD3 HSPA1A HSPA1B VPS13B

5.09e-0614871602133957083
Pubmed

DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism.

TET2 TET3 DNMT3A

5.26e-068160328614801
Pubmed

CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist.

CCL2 CCL7 CCL13

5.26e-068160310477718
Pubmed

Hsp72 preserves muscle function and slows progression of severe muscular dystrophy.

DMD HSPA1A HSPA1B

5.26e-068160322495301
Pubmed

Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis.

CCL2 CCL7 CCL13

5.26e-068160319865101
Pubmed

Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, AND CX3C families of chemokines.

CCL28 CCL2 CCL13 CX3CL1

6.97e-0627160412126650
Pubmed

Dachshund homologues play a conserved role in islet cell development.

EYA4 EYA1 EYA2 EYA3

6.97e-0627160420869363
Pubmed

TET1 regulates fibroblast growth factor 8 transcription in gonadotropin releasing hormone neurons.

TET2 TET3 DNMT3A

7.87e-069160331361780
Pubmed

Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass.

AMY2A AMY2B CCND1

7.87e-069160315467835
Pubmed

Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity.

FAM98A HNRNPH1 DDX1 HSPA1A

8.10e-0628160438492217
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

GTPBP4 CACNA1E DMXL2 CTTNBP2 MYCBP2 ADNP TMEM132B CASK MTOR N4BP2 RPTOR PEX5 TNKS PARD3 HOMER2 ARMC8

1.04e-059631601628671696
Pubmed

Impact of lactobacilli on orally acquired listeriosis.

AMY2A AMY2B CEP192 SLC10A2 HP CCL2 HERC6

1.07e-05162160723012479
Pubmed

Dysregulation of the TET family of epigenetic regulators in lymphoid and myeloid malignancies.

TET2 TET3 DNMT3A

1.12e-0510160331467060
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

GTPBP4 NUP107 GART FAM98A HNRNPH1 ZNF12 EEF1D COG1 TTLL6 PRAP1 KDM2B DMD HSPA1A PCID2

1.12e-057541601435906200
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

TET2 TTC28 KLHDC2 MYCBP2 ARHGAP17 FAM98A CEP192 DDX1 ESYT2 PIK3C3 MTOR N4BP2 RPTOR PARD3 EIF4E2

1.15e-058611601536931259
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

USP34 EYA4 IFT172 QTRT2 EYA1 EYA2 EYA3 CASK ESYT2 MTOR TOMM34 SDF2L1 TNKS DIAPH3 DMD ARMC8

1.20e-059741601628675297
Pubmed

Identification of Redox and Glucose-Dependent Txnip Protein Interactions.

ADNP YEATS2 HSPA1A HSPA1B

1.40e-0532160427437069
Pubmed

USP45 and Spindly are part of the same complex implicated in cell migration.

USP34 EPRS1 CTTNBP2 TUT7 CPNE5 HNRNPH1 EEF1D HSPA1A

1.42e-05235160830258100
Pubmed

Tet2- and Tet3- Mediated Cytosine Hydroxymethylation in Six2 Progenitor Cells in Mice Is Critical for Nephron Progenitor Differentiation and Nephron Endowment.

TET2 CCL2 TET3 COL1A1

1.59e-0533160436522157
Pubmed

A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.

USP34 INPP5D CCL2 CCL7 CCL13

1.60e-0568160522412388
Pubmed

Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy.

PIK3C3 HSPA1A HSPA1B

2.04e-0512160323569248
Pubmed

Respiratory distress and early neonatal lethality in Hspa4l/Hspa4 double-mutant mice.

CCND1 HSPA1A HSPA1B

2.04e-0512160323980576
Pubmed

Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo.

CCL2 CCL7 CCL13

2.04e-0512160312149192
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

TTC28 STXBP5 IFT172 CEP192 POGZ YEATS2 MCM3AP TET3 VPS13B PDZD2

2.07e-054071601012693553
Pubmed

Exercise induces hepatosplanchnic release of heat shock protein 72 in humans.

HSPA1A HSPA1B

2.10e-052160212411538
Pubmed

The action of human pancreatic and salivary isoamylases on starch and glycogen.

AMY2A AMY2B

2.10e-0521602890964
Pubmed

In vitro transcription of a human hsp 70 heat shock gene by extracts prepared from heat-shocked and non-heat-shocked human cells.

HSPA1A HSPA1B

2.10e-05216023786141
Pubmed

The short MCK1350 promoter/enhancer allows for sufficient dystrophin expression in skeletal muscles of mdx mice.

CKM DMD

2.10e-052160211922612
Pubmed

Double somatic mosaic mutations in TET2 and DNMT3A--origin of peripheral T cell lymphoma in a case.

TET2 DNMT3A

2.10e-052160225687841
Pubmed

Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are increased after labour in foetal membranes and myometrium and are essential for TNF-α-induced expression of pro-labour mediators.

BIRC2 BIRC3

2.10e-052160225046208
Pubmed

A comparative immunohistochemical study on amylase localization in the rat and human exocrine pancreas.

AMY2A AMY2B

2.10e-052160211376382
Pubmed

DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages.

TET2 DNMT3A

2.10e-052160235931086
Pubmed

Characterization of the binding between a 70-kDa heat shock protein, HspA1A, and phosphoinositides.

HSPA1A HSPA1B

2.10e-052160226923070
Pubmed

Clonal hematopoiesis driven by DNMT3A and TET2 mutations: role in monocyte and macrophage biology and atherosclerotic cardiovascular disease.

TET2 DNMT3A

2.10e-052160234654019
Pubmed

CRISPR-Mediated Gene Editing to Assess the Roles of Tet2 and Dnmt3a in Clonal Hematopoiesis and Cardiovascular Disease.

TET2 DNMT3A

2.10e-052160229728415
Pubmed

Hsp70 protects from stroke in atrial fibrillation patients by preventing thrombosis without increased bleeding risk.

HSPA1A HSPA1B

2.10e-052160226976620
Pubmed

Epigenetic silencing of TET2 and TET3 induces an EMT-like process in melanoma.

TET2 TET3

2.10e-052160227852070
Pubmed

Astrocyte targeted overexpression of Hsp72 or SOD2 reduces neuronal vulnerability to forebrain ischemia.

HSPA1A HSPA1B

2.10e-052160220235222
Pubmed

Genetic determinants of HSP70 gene expression following heat shock.

HSPA1A HSPA1B

2.10e-052160220876613
Pubmed

The C-terminal BAG domain of BAG5 induces conformational changes of the Hsp70 nucleotide-binding domain for ADP-ATP exchange.

HSPA1A HSPA1B

2.10e-052160220223214
Pubmed

Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells.

HSPA1A HSPA1B

2.10e-052160220093776
Pubmed

Bacterial infection elicits heat shock protein 72 release from pleural mesothelial cells.

HSPA1A HSPA1B

2.10e-052160223704948
Pubmed

Prevalence and prognostic significance of DNMT3A- and TET2- clonal haematopoiesis-driver mutations in patients presenting with ST-segment elevation myocardial infarction.

TET2 DNMT3A

2.10e-052160235339897
Pubmed

Nuclear heat shock protein 72 as a negative regulator of oxidative stress (hydrogen peroxide)-induced HMGB1 cytoplasmic translocation and release.

HSPA1A HSPA1B

2.10e-052160217513788
Pubmed

Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2.

BIRC2 BIRC3

2.10e-052160229452637
Pubmed

IL-6 activates HSP72 gene expression in human skeletal muscle.

HSPA1A HSPA1B

2.10e-052160212207910
Pubmed

TET2 and DNMT3A mutations and exceptional response to 4'-thio-2'-deoxycytidine in human solid tumor models.

TET2 DNMT3A

2.10e-052160234039392
Pubmed

Concurrent action of purifying selection and gene conversion results in extreme conservation of the major stress-inducible Hsp70 genes in mammals.

HSPA1A HSPA1B

2.10e-052160229572464
Pubmed

Genomic characterization of the mouse inhibitor of apoptosis protein 1 and 2 genes.

BIRC2 BIRC3

2.10e-05216029441758
Pubmed

DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phenotypes and different genetic predispositions.

TET2 DNMT3A

2.10e-052160228655780
Pubmed

Role of Chromatin Remodeling Genes and TETs in the Development of Human Midbrain Dopaminergic Neurons.

TET2 TET3

2.10e-052160232367481
Pubmed

HSP70.1 and -70.3 are required for late-phase protection induced by ischemic preconditioning of mouse hearts.

HSPA1A HSPA1B

2.10e-052160212714332
Pubmed

Inflammation-induced, 3'UTR-dependent translational inhibition of Hsp70 mRNA impairs intestinal homeostasis.

HSPA1A HSPA1B

2.10e-052160219299581
Pubmed

Essential and non-redundant roles of p48 (ISGF3 gamma) and IRF-1 in both type I and type II interferon responses, as revealed by gene targeting studies.

IRF1 IRF9

2.10e-05216029078371
Pubmed

Genome-wide association study of genetic predictors of anti-tumor necrosis factor treatment efficacy in rheumatoid arthritis identifies associations with polymorphisms at seven loci.

EYA4 PDZD2

2.10e-052160221061259
Pubmed

Loss of ten-eleven translocation 2 induces cardiac hypertrophy and fibrosis through modulating ERK signaling pathway.

TET2 HSPA1B

2.10e-052160233791790
Pubmed

hsp72, a host determinant of measles virus neurovirulence.

HSPA1A HSPA1B

2.10e-052160216971451
Pubmed

Chemokines CCL2 and CCL7, but not CCL12, play a significant role in the development of pain-related behavior and opioid-induced analgesia.

CCL2 CCL7

2.10e-052160231003094
Pubmed

IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer.

BIRC2 BIRC3

2.10e-052160220651737
Pubmed

Heat shock protein 70 promotes lipogenesis in HepG2 cells.

HSPA1A HSPA1B

2.10e-052160229631603
Pubmed

The human amylase-encoding genes amy2 and amy3 are identical to AMY2A and AMY2B.

AMY2A AMY2B

2.10e-05216022483397
Pubmed

Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli.

BIRC2 BIRC3

2.10e-052160210797013
Pubmed

Role of membrane Hsp70 in radiation sensitivity of tumor cells.

HSPA1A HSPA1B

2.10e-052160226197988
Pubmed

Enhanced response to pulmonary Streptococcus pneumoniae infection is associated with primary ciliary dyskinesia in mice lacking Pcdp1 and Spef2.

SPEF2 CFAP221

2.10e-052160224360193
Pubmed

Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning.

MTOR RPTOR

2.10e-052160227018708
Pubmed

Human pancreatic alpha-amylase: phenotypic codominance and new electrophoretic variants.

AMY2A AMY2B

2.10e-0521602309725
Pubmed

Surface expression of a C-terminal alpha-helix region in heat shock protein 72 on murine LL/2 lung carcinoma can be recognized by innate immune sentinels.

HSPA1A HSPA1B

2.10e-052160219157555
Pubmed

Hsp70 regulates the interaction between the peroxisome targeting signal type 1 (PTS1)-receptor Pex5p and PTS1.

PEX5 HSPA1A

2.10e-052160211415446
Pubmed

Heat Shock Protein 70 Is Involved in the Efficiency of Preconditioning with Cyclosporine A in Renal Ischemia Reperfusion Injury by Modulating Mitochondrial Functions.

HSPA1A HSPA1B

2.10e-052160237298493
Pubmed

Glioma-derived CCL2 and CCL7 mediate migration of immune suppressive CCR2+/CX3CR1+ M-MDSCs into the tumor microenvironment in a redundant manner.

CCL2 CCL7

2.10e-052160236685592
Pubmed

Proteinase-activated receptor-1, CCL2, and CCL7 regulate acute neutrophilic lung inflammation.

CCL2 CCL7

2.10e-052160223972264
Pubmed

The actions of exogenous leucine on mTOR signalling and amino acid transporters in human myotubes.

PIK3C3 MTOR

2.10e-052160221702994
Pubmed

Cathepsin S Contributes to the Pathogenesis of Muscular Dystrophy in Mice.

DMD CTSS

2.10e-052160226966179
Pubmed

Role of the C-terminal region of mouse inducible Hsp72 in the recognition of peptide substrate for chaperone activity.

HSPA1A HSPA1B

2.10e-052160215498567
Cytoband8q22.2

SPAG1 KLF10 VPS13B

6.99e-052316038q22.2
Cytoband17q11.2-q12

CCL2 CCL7

2.51e-047160217q11.2-q12
GeneFamilyEYA transcriptional coactivator and phosphatases

EYA4 EYA1 EYA2 EYA3

1.25e-09410941044
GeneFamilyChemokine ligands|Endogenous ligands

CCL28 CCL2 CCL7 CCL13 CX3CL1

7.32e-06451095483
GeneFamilyMTOR complex 1|MTOR complex 2

MTOR RPTOR

2.14e-04410921332
GeneFamilySuper elongation complex|YEATS domain containing

YEATS2 MLLT3

2.14e-04410921283
GeneFamilyEF-hand domain containing|Nucleotide excision repair|Transcription and export complex 2

MCM3AP PCID2

3.56e-04510921276
GeneFamilyRing finger proteins|Baculoviral IAP repeat containing|Caspase recruitment domain containing

BIRC2 BIRC3

9.85e-0481092419
GeneFamilyZinc fingers CXXC-type

KDM2B TET3

2.28e-03121092136
GeneFamilyDyneins, axonemal

DNAH3 DNAH8

4.62e-03171092536
GeneFamilyHeat shock 70kDa proteins

HSPA1A HSPA1B

4.62e-03171092583
GeneFamilyZinc fingers|Zinc fingers PARP-type|Poly(ADP-ribose) polymerases

PARP14 TNKS

4.62e-03171092684
CoexpressionAtlasDevelopingKidney_e15.5_Cap mesenchyme_emap-27738_k-means-cluster#2_top-relative-expression-ranked_200

EYA4 KLHDC2 CHST9 EYA1 HSPA1A FRMD3

1.06e-05671586gudmap_developingKidney_e15.5_Cap mesenchyme_200_k2
CoexpressionAtlaskidney_adult_Mesangium_Meis_top-relative-expression-ranked_1000

FLT1 TTC28 FAM13C BIRC3 IRF1 LRRK1 PARP14 PREX2 BCLAF3 IRF9 ESYT2 GVINP1 DMD HERC6 HSPA1A HSPA1B DCBLD2 CTSS FRMD3

2.72e-0587215819gudmap_kidney_adult_Mesangium_Meis_1000
ToppCellE16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal-Deuterosomal_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCDC60 SPEF2 VSIG1 AKAP14 CPNE5 HP TTLL6 HOMER2

1.46e-071641608d9531848105d606adedde65426177cf851140e31
ToppCellLPS-IL1RA+antiTNF-Epithelial_airway|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH3 EYA4 TOGARAM2 CHST9 FBXO16 HP TTLL6 SDR16C5

1.46e-071641608e4d4c59aebe5cacd4ecdb907facd044dc82a831d
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ABHD6 CHST9 EYA1 FAN1 FBXO16 MFSD2A DHX32 DNAJC1

2.98e-071801608c72f15763ba707189e29c85db533557f01c7fdb1
ToppCellAdult-Epithelial-ciliated_cell-D122|Adult / Lineage, Cell type, age group and donor

CCDC60 DNAH3 CDHR3 SPEF2 TOGARAM2 AKAP14 CHST9 EYA1

3.25e-0718216087ded554a4b441e6496db673ba206c0d76ccad7d9
ToppCellCOPD-Epithelial-Ciliated|World / Disease state, Lineage and Cell class

CCDC60 DNAH3 CDHR3 SPEF2 TOGARAM2 CHST9 EYA1 CFAP221

4.87e-071921608eab1105cd1a98cfcd3d74dc5c9b89e1799bba59e
ToppCellIPF-Epithelial|IPF / Disease state, Lineage and Cell class

CCDC60 DNAH3 CDHR3 SPEF2 EYA1 EYA2 CFAP221 PARD3

5.70e-07196160887d9881cfec461a5d89b688a83749b618c519485
ToppCellAT2_cells-IPF_03|World / lung cells shred on cell class, cell subclass, sample id

ERBB3 VSIG1 BIRC3 CCND1 CASK CX3CL1 SERPIND1 COL1A1

5.92e-0719716085e0d222872a25bb9e9069d3dffda2844bb69874a
ToppCellTracheal-NucSeq|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations

USP34 TTC28 STXBP5 MLLT3 TNKS DMD PARD3 VPS13B

6.39e-07199160894b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCellParenchyma_COVID-19-Epithelial-TX|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

ERBB3 CDHR3 CHST9 CCND1 NTN4 MFSD2A CFAP221 SDR16C5

6.63e-072001608d5426cd318a8f90c0bd8f9804351ab230fafc995
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ERBB3 CDHR3 CHST9 CCND1 NTN4 MFSD2A CFAP221 SDR16C5

6.63e-07200160821d9cf3cd3696ad6b745c7c036798f04b6ce5160
ToppCellLung_Parenchyma-Severe-Epithelial|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

ERBB3 CDHR3 CHST9 CCND1 NTN4 MFSD2A CFAP221 SDR16C5

6.63e-07200160833658d5d09e2eaff60f4dd88837d4252328eab63
ToppCellCOVID-19-Epithelial_cells-Airway_mucous|COVID-19 / group, cell type (main and fine annotations)

CCDC60 DNAH3 CDHR3 SPEF2 CHST9 EYA1 ANKRD1

1.27e-0615116078216462e723fec2797387929dde095370947e10a
ToppCellControl-Epithelial_airway-Ciliated_cells-Ciliated|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CCDC60 DNAH3 EYA4 TOGARAM2 FBXO16 TTLL6 CFAP221

1.44e-0615416074e3bc24043144143842627cacf6f90dda2228910
ToppCellControl-Epithelial_airway-Ciliated_cells|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CCDC60 DNAH3 EYA4 TOGARAM2 FBXO16 TTLL6 CFAP221

1.44e-0615416077556a4b2b062da5ae7ec2bbb66e745e7662db628
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CCDC60 CNBD2 EIF2D DIAPH3 CX3CL1 IQGAP3 FRMD3

1.51e-0615516078e239470799426ea474a36f57e1b7e0d9365ca5f
ToppCellControl-Epithelial_airway|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAH3 EYA4 TOGARAM2 CHST9 FBXO16 TTLL6 SDR16C5

1.71e-06158160735aee1c3b92169e73569331022833cb44ab7e7e8
ToppCellCiliated_cells-B-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

DNAH3 EYA4 CDHR3 SPEF2 TOGARAM2 EYA1 RYR3

2.20e-0616416070e9961acbb1d6c0089e6805ba6756736fa4d8bed
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLT1 TUT7 PARP14 PREX2 GVINP1 TNKS HERC6

3.78e-06178160701dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 NOX5 CDHR3 SPEF2 TOGARAM2 TTLL6 CFAP221

3.92e-0617916075e5f1cdf4aa66868d45b74ba91e20e848a3cbaff
ToppCellfacs-GAT-Fat-3m-Epithelial|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDHR3 TOGARAM2 TMEM132B FBXO16 CCL28 TTLL6 CFAP221

4.22e-06181160711cb84528f7ca084f0a92eda4f2e18e63a428fe9
ToppCellfacs-GAT-Fat-3m-Epithelial-epithelial_cell|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDHR3 TOGARAM2 TMEM132B FBXO16 CCL28 TTLL6 CFAP221

4.22e-061811607e97cbaafb93fdbee8e3cf4a06e6bcf121d941403
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MACC1 CTTNBP2 CHST9 NTN4 DIAPH3 PARD3 FRMD3

4.22e-0618116076956ecd6264f7469a25e555673bce4eb97d28f7a
ToppCellfacs-GAT-Fat-3m-Epithelial-nan|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDHR3 TOGARAM2 TMEM132B FBXO16 CCL28 TTLL6 CFAP221

4.22e-0618116075ffeca29e4d31a20c110d27af128ed024a79ad56
ToppCellControl-Epithelial_cells-Airway_ciliated|Control / group, cell type (main and fine annotations)

CCDC60 DNAH3 CDHR3 SPEF2 TOGARAM2 CHST9 EYA1

4.37e-061821607fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCellChildren_(3_yrs)-Epithelial-club_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ABCC5 CCND1 EYA1 EYA2 MLLT3 CX3CL1 HOMER2

4.37e-061821607215c303df42f13597b2c7a95cb157c6bc7aca9a1
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MACC1 CTTNBP2 CHST9 EYA1 NTN4 DIAPH3 PARD3

4.53e-06183160792fbd83a9d13ee91065cbd479fb298f1fd564568
ToppCellCOVID-19-Epithelial_cells-Airway_ciliated|COVID-19 / group, cell type (main and fine annotations)

CCDC60 DNAH3 CDHR3 SPEF2 TOGARAM2 CHST9 EYA1

4.87e-06185160718a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCellAdult-Epithelial-ciliated_cell-D175|Adult / Lineage, Cell type, age group and donor

CCDC60 DNAH3 CDHR3 SPEF2 TOGARAM2 AKAP14 EYA1

4.87e-06185160730f4980dee6cd5959655f8d74049f3bfb5312611
ToppCellnormal_Lung-Myeloid_cells-Activated_DCs|normal_Lung / Location, Cell class and cell subclass

N4BP2L1 SCN11A BIRC3 LRRK1 KDM2B TOMM34 HOMER2

5.04e-0618616070987c9a39503eb6c75a2bf4db98b2b2fd46956fb
ToppCellnormal_Lung-Myeloid_cells-Activated_DCs|Myeloid_cells / Location, Cell class and cell subclass

N4BP2L1 SCN11A EYA4 BIRC3 LRRK1 KDM2B HOMER2

5.04e-06186160700ad1239b952119b3fd2e6af8f034cba3488f9c1
ToppCelldroplet-Lung-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l39|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GALNT16 SULT2A1 SYTL5 ANKRD1 DMD HSPA1A HSPA1B

5.23e-061871607218c9b4f28499389c43005d9626af2ac01066027
ToppCelldroplet-Lung-18m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GALNT16 SULT2A1 SYTL5 ANKRD1 DMD HSPA1A HSPA1B

5.23e-061871607c7ac4b328efc2ebb72f71154661914193ff402ca
ToppCellControl-Myeloid-DC_Mature|Control / Disease state, Lineage and Cell class

N4BP2L1 EYA4 BIRC2 BIRC3 LRRK1 KDM2B HOMER2

5.23e-061871607049780ca2a3e6adcd89dc2cf3095b5ad068b244a
ToppCellLA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

CACNA1E EYA4 NRAP NEB CPNE5 ANKRD1 DMD

5.41e-0618816076d249fe92d51a19da19ec14bb2262d394255d577
ToppCellAdult-Epithelial-ciliated_cell-D231|Adult / Lineage, Cell type, age group and donor

CCDC60 DNAH3 CDHR3 SPEF2 TOGARAM2 CHST9 EYA1

5.41e-06188160734b11f72ca73153d02edcd09b38983ad1a504659
ToppCellEpithelial-ciliated_cell|World / Lineage, Cell type, age group and donor

CCDC60 DNAH3 CDHR3 SPEF2 TOGARAM2 CHST9 EYA1

5.41e-06188160761a459f3fe57e5728efc72637ff2edc2d343492b
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

CCDC60 DNAH3 CDHR3 SPEF2 TOGARAM2 CHST9 EYA1

5.41e-0618816072b6dfc88be9ded7b88da9fe78a9cd9f9b3af8af3
ToppCellPND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DNAH3 CDHR3 SPEF2 TOGARAM2 AKAP14 FBXO16 TTLL6

5.60e-061891607b55de812043b670cbde810d7d42f45909b6d66ef
ToppCellCOVID-19-lung-Ciliated|COVID-19 / Disease (COVID-19 only), tissue and cell type

CCDC60 DNAH3 CDHR3 SPEF2 TOGARAM2 CHST9 EYA1

5.60e-061891607a2da5debd10f27b1280b40141ef0bfef007cc72c
ToppCellTransplant_Alveoli_and_parenchyma-Epithelial-Ciliated_1|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X

CCDC60 DNAH3 CDHR3 SPEF2 TOGARAM2 AKAP14 CHST9

5.60e-061891607dc440015949a768188c67661b6be63b1ead1a0f0
ToppCellPND01-Epithelial-Epithelial_Airway|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DNAH3 CDHR3 SPEF2 TOGARAM2 AKAP14 FBXO16 TTLL6

5.60e-06189160738cde34295566a4ecaf7d0a81c5a192cf17d0459
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 SPAG1 CDHR3 SPEF2 AKAP14 CHST9 PRAP1

5.60e-061891607b4b93bd10b7e3cc16e54ff73beac230f519c010a
ToppCellCOVID-19-lung-Ciliated|lung / Disease (COVID-19 only), tissue and cell type

CCDC60 DNAH3 CDHR3 SPEF2 TOGARAM2 CHST9 EYA1

5.60e-06189160727329c4661aebabd19fac7fe5dca263fe99d76f3
ToppCellChildren_(3_yrs)-Epithelial-ciliated_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CCDC60 DNAH3 CDHR3 SPEF2 TOGARAM2 CHST9 EYA1

5.60e-06189160768a3cf7763d6f9b95d6d6524eff7a16042703f1d
ToppCellAdult-Epithelial-ciliated_cell|Adult / Lineage, Cell type, age group and donor

CCDC60 DNAH3 CDHR3 SPEF2 TOGARAM2 CHST9 EYA1

5.60e-061891607b679920f0993e917dd86da082113bfbd85ea1ca5
ToppCellPND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DNAH3 CDHR3 SPEF2 TOGARAM2 AKAP14 FBXO16 TTLL6

5.60e-0618916074e83e49d1265ffe507fdb72924c77c4d1c73f0bd
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)

SPAG1 ABCC5 BIRC2 CNBD2 PPP1R13L CCL2 EEF1AKMT2

5.80e-061901607651a1d3ae286e40f9d9f60e438211c6148d24143
ToppCellPND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DNAH3 CDHR3 SPEF2 TOGARAM2 AKAP14 FBXO16 TTLL6

6.00e-06191160796483adb97c81208aa513782550acd8a08b63866
ToppCellnucseq-Epithelial-Epithelial_Airway|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CCDC60 DNAH3 CDHR3 SPEF2 TOGARAM2 CHST9 EYA1

6.00e-0619116071c528f72c9ef3ef3a850b05e4a9715190832270c
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CCDC60 DNAH3 CDHR3 SPEF2 TOGARAM2 CHST9 EYA1

6.00e-061911607e417bf491f8b8d7838a61f7f4f6b1740ba97aa3f
ToppCellnucseq-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CCDC60 DNAH3 CDHR3 SPEF2 TOGARAM2 CHST9 EYA1

6.00e-0619116079d31c8424d35bdc0c27188b68bfd0f731af3600b
ToppCellIPF-Epithelial-Ciliated|World / Disease state, Lineage and Cell class

CCDC60 DNAH3 CDHR3 SPEF2 TOGARAM2 CHST9 CFAP221

6.21e-061921607d903bbd6c18e29e2c4cdedeb3fea1fd5ad7baa11
ToppCellASK440-Epithelial-Ciliated|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

DNAH3 SPAG1 CDHR3 SPEF2 TOGARAM2 AKAP14 CHST9

6.43e-061931607a0baa8be6f590b2031fede22be588715ae458e93
ToppCellASK440-Epithelial-Secretory|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

ABCC5 CHST9 CCND1 EYA2 SYTL5 CX3CL1 HOMER2

6.43e-06193160750e98d91697c7af6a3de39e52edde6dd2b67b512
ToppCell10x3'2.3-week_17-19-Mesenchymal_myocytic-stroma-myofibroblast|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

EYA4 CCND1 NEB NTN4 ANKRD1 CCL2 DMD

6.43e-06193160702dfd1df1e7fc84bfca2b0c95138b5b4408bb5d1
ToppCellASK440-Epithelial-Ciliated|Epithelial / Donor, Lineage and Cell class of Lung cells from Dropseq

DNAH3 SPAG1 CDHR3 SPEF2 TOGARAM2 AKAP14 CHST9

6.65e-061941607c84a7fa94fb06e08aae04db56c8c313b0afde1d7
ToppCell368C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

TET2 INPP5D TRPM2 CCL2 CCL13 HSPA1A HSPA1B

6.65e-06194160758046894446cb250814252a23f60fdd59c114d77
ToppCellControl-Epithelial-Ciliated|World / Disease state, Lineage and Cell class

CCDC60 DNAH3 CDHR3 SPEF2 AKAP14 CHST9 CFAP221

6.65e-061941607958e648138676d46698090b4046cb484083ae449
ToppCellBL-critical-LOC-Epithelial-unknown_epithelial|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FAM13C CDHR3 SPEF2 AKAP14 CHST9 CCL28 PEX5

6.65e-0619416076140ff8e776429c9593607da418b2d9c4f399d41
ToppCellIPF-Multiplet-Multiplet|IPF / Disease state, Lineage and Cell class

DNAH3 CDHR3 SPEF2 EYA1 NTN4 CFAP221 PARD3

6.87e-061951607fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell3'-Airway_Nasal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC60 DNAH3 SPAG1 SPEF2 AKAP14 CCL28 CFAP221

6.87e-061951607d211a836cf711fdb91b10d512f09d462be937cc5
ToppCellIPF-Multiplet|IPF / Disease state, Lineage and Cell class

DNAH3 CDHR3 SPEF2 EYA1 NTN4 CFAP221 PARD3

6.87e-061951607eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCellBL-critical-LOC-Epithelial-Ciliated|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

DNAH3 IFT172 CDHR3 SPEF2 AKAP14 CHST9 CFAP221

6.87e-06195160707a6bcef6af93ed87df455dee624037cb75e011a
ToppCellControl_saline-Epithelial_airway-airway_epithelial-Ciliated|Control_saline / Treatment groups by lineage, cell group, cell type

CCDC60 DNAH3 SPAG1 TOGARAM2 TTLL6 CFAP221 SDR16C5

6.87e-06195160760067b5359174f0d1a8b5748bfc0690762e9e740
ToppCellCOPD-Multiplet|COPD / Disease state, Lineage and Cell class

DNAH3 CDHR3 CHST9 EYA1 HNRNPH1 CFAP221 PARD3

7.11e-0619616076d02d494196e3f857d53eea46d9419690d43beca
ToppCellBronchial-NucSeq|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations

TTC28 CASK MLLT3 DMD PARD3 VPS13B PDZD2

7.11e-061961607ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCellCOPD-Multiplet-Multiplet|COPD / Disease state, Lineage and Cell class

DNAH3 CDHR3 CHST9 EYA1 HNRNPH1 CFAP221 PARD3

7.11e-061961607af4cdc61830685a888a1209826c23bcf54a43084
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 SPAG1 IFT172 CDHR3 SPEF2 AKAP14 CHST9

7.35e-06197160791637bdeab85024b5a02d1066f76cb803a2d6420
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 SPAG1 IFT172 CDHR3 SPEF2 AKAP14 CHST9

7.35e-06197160722c87dd15dc57bd0aa98a204c9fc9b3b9b573b45
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 CDHR3 SPEF2 TOGARAM2 TTLL6 CFAP221 DMD

7.35e-06197160774a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 SPAG1 IFT172 CDHR3 SPEF2 AKAP14 CHST9

7.35e-0619716073bbf068d2ad8196fbc85d3f311a7c54c9aece856
ToppCell5'-Airway_Nasal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 SPAG1 IFT172 CDHR3 SPEF2 AKAP14 CHST9

7.35e-06197160787db09f341e2b20eb6e1c3e917cb5c960387b3e9
ToppCellLPS_only-Epithelial_airway|LPS_only / Treatment groups by lineage, cell group, cell type

CCDC60 DNAH3 EYA4 AKAP14 CHST9 PPP1R13L SDR16C5

7.59e-061981607ba090210392e001a3f7bdf09371b3f0e0c8c7ef3
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAH3 MACC1 SPAG1 IFT172 CDHR3 SPEF2 CHST9

7.59e-061981607d0ecace1fad24ce50b0935036fabb07e6c9e372d
ToppCellLPS_only-Epithelial_airway-airway_epithelial|LPS_only / Treatment groups by lineage, cell group, cell type

CCDC60 DNAH3 EYA4 AKAP14 CHST9 PPP1R13L SDR16C5

7.59e-061981607e035380578c01b0243bfef29ca9b50cc17cce771
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_ciliated-Ciliated|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CCDC60 DNAH3 CDHR3 SPEF2 AKAP14 CHST9 EYA1

8.11e-062001607926a7ea94b5908aebf103893ea83ce9d25285b65
ToppCellBiopsy_IPF-Epithelial-Ciliated|Biopsy_IPF / Sample group, Lineage and Cell type

DNAH3 IFT172 CDHR3 SPEF2 AKAP14 CHST9 CFAP221

8.11e-062001607bb8c99156e547a8eb6599b6b6bc3c66bf77af7f8
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-Ciliated|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DNAH3 SPAG1 CDHR3 SPEF2 AKAP14 CHST9 CFAP221

8.11e-062001607f1a49bc818054fb0734d3b84725ee6487b034567
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_ciliated|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CCDC60 DNAH3 CDHR3 SPEF2 AKAP14 CHST9 EYA1

8.11e-06200160706ce6e03498ba38ef6a06eaf2731e3b2eeda59eb
ToppCellLPS_IL1RA_TNF-Epithelial_airway|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

CCDC60 DNAH3 TOGARAM2 AKAP14 CHST9 TTLL6 SDR16C5

8.11e-06200160772c1d9eeaed4b3ee6b6c602e8aa29efc2e8744eb
ToppCellBiopsy_Other_PF-Epithelial-Ciliated|Biopsy_Other_PF / Sample group, Lineage and Cell type

CCDC60 DNAH3 CDHR3 SPEF2 AKAP14 CHST9 CFAP221

8.11e-062001607721371698bce8890853fb6b6b01a2c20293b39e9
ToppCellLPS_IL1RA_TNF-Epithelial_airway-airway_epithelial|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

CCDC60 DNAH3 TOGARAM2 AKAP14 CHST9 TTLL6 SDR16C5

8.11e-062001607da12821e8a0657869ca0f75d351cce2d7605a505
ToppCellParenchyma_COVID-19-Epithelial-TX-Ciliated|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

DNAH3 SPAG1 CDHR3 SPEF2 AKAP14 CHST9 CFAP221

8.11e-062001607d7ae09189cf0b7e2f7e7fc6b0921975b75aa7d62
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-Ciliated-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

DNAH3 SPAG1 CDHR3 SPEF2 AKAP14 CHST9 CFAP221

8.11e-062001607cf59110547cc66b5f4a2999735336b0309ba9b0d
ToppCellGlobus_pallidus-Macroglia-CSF_related-EPENDYMAL-Ependymal_(Ccdc153)--|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

DNAH3 CDHR3 AKAP14 HP TTLL6 CFAP221

8.70e-061331606a653282bf871dc9eb47fbf1d55b1eb32ae749c04
ToppCellGlobus_pallidus-Macroglia-CSF_related-EPENDYMAL-Ependymal_(Ccdc153)|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

DNAH3 CDHR3 AKAP14 HP TTLL6 CFAP221

8.70e-0613316062caaacb4fb4358c5589c81eaf8dffb85f318fb13
ToppCellGlobus_pallidus-Macroglia-CSF_related-EPENDYMAL|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

DNAH3 CDHR3 AKAP14 HP TTLL6 CFAP221

8.70e-0613316062d0cade52d79c3d0b6f77418103244150e2ea7fb
ToppCellGlobus_pallidus-Macroglia-CSF_related-EPENDYMAL-Ependymal_(Ccdc153)-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

DNAH3 CDHR3 AKAP14 HP TTLL6 CFAP221

8.70e-06133160625ea1d82a0fc9fed191b9dd33f2a35404a665e7d
ToppCellGlobus_pallidus-Macroglia-CSF_related|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

DNAH3 CDHR3 AKAP14 HP TTLL6 CFAP221

8.70e-06133160651c60b6d5648968783bffbb22c28d9abaf6243d5
ToppCell(08)_PNEC-(2)_48hpi|(08)_PNEC / shred by cell type and Timepoint

CTTNBP2 CDHR3 NEB MFSD2A SYTL5 FRMD3

1.26e-051421606e95d34170f5053678e0dd9793e68d93c03b05822
ToppCellLPS-antiTNF-Epithelial_airway-Ciliated_cells-Ciliated|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CCDC60 DNAH3 TOGARAM2 FBXO16 TTLL6 CFAP221

1.60e-051481606d61123f0c811287843d066b932b4a9ff09c07c5b
ToppCellLPS-antiTNF-Epithelial_airway-Ciliated_cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CCDC60 DNAH3 TOGARAM2 FBXO16 TTLL6 CFAP221

1.60e-051481606c8e93b87212f55774223caa385859c566fa1981f
ToppCellfacs-Heart-RA-24m-Mesenchymal-atrial_myocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TOGARAM2 CPNE5 RYR3 CKM HP ANKRD1

2.23e-0515716069021900d9b1a71210c9c414a9d165eaf399eb607
ToppCellfacs-Heart-RA-24m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TOGARAM2 CPNE5 RYR3 CKM HP ANKRD1

2.23e-051571606c8c627ca181856cd31dba4cf073c2be659a49dc1
ToppCelldroplet-Liver-LIVER_HEP-30m-Myeloid-macrophage/monocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYCBP2 ARHGAP17 EYA1 GVINP1 DIAPH3 IQGAP3

2.66e-05162160693bd29c52846c3156b8b0d2e39c552373efdfe93
ToppCellLPS-antiTNF-Epithelial_airway-Mes-Epi-like|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HNRNPH1 RYR3 THEM4 DIAPH3 SDR16C5 IQGAP3

2.85e-0516416064307b002fb41ddfc7ab8a6bca66a60942c250052
ToppCellLPS-antiTNF-Epithelial_airway-Mes-Epi-like-Airway|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HNRNPH1 RYR3 THEM4 DIAPH3 SDR16C5 IQGAP3

2.85e-0516416061d84aa5b925f502ee9c5fa39714490f613a58028
ToppCell5'-Parenchyma_lung-Immune_Myeloid-Dendritic-CD1c-positive_myeloid_dendritic_cell-DC2_(CD1c+_dendritic_cell)-DC2_L.1.2.1.3|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TOGARAM2 LRRK1 ANKRD1 KDM2B HSPA1A FRMD3

2.95e-05165160676abebe80e5f8bf44825bb619ae86fcb6f66ffeb
ToppCellfacs-Large_Intestine-Proximal-18m-Epithelial-Enterocyte_(Proximal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACOX1 ABHD6 ABCC5 SLC10A2 PRAP1 CTSS

3.06e-05166160622b31acbbef1936ce19b393cf880c63ea2fa0f1b
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Lgr5+_amplifying_undifferentiated_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CCND1 LRRK1 EYA2 CCL28 DMD FRMD3

3.27e-051681606d69452e2cfeb74023b5cf3d09064d7dcad0008ec
DrugAC1NUKN7

CCL2 CCL7 CCL13

1.33e-0641593CID005481434
Diseaseeye disease (implicated_via_orthology)

EYA4 EYA1 EYA2 EYA3

1.03e-0861534DOID:5614 (implicated_via_orthology)
Diseasebranchiootorenal syndrome (implicated_via_orthology)

EYA4 EYA1 EYA2 EYA3

2.40e-0871534DOID:14702 (implicated_via_orthology)
Diseaseleukemia

BIRC2 BIRC3 CCND1 PPP1R13L HP

9.91e-06551535C0023418
Diseasecardiovascular system disease (is_marker_for)

HP CCL2 HSPA1A

1.60e-05101533DOID:1287 (is_marker_for)
Diseasepulmonary embolism (biomarker_via_orthology)

HP CCL2 CX3CL1

2.91e-05121533DOID:9477 (biomarker_via_orthology)
Diseasehepatocellular carcinoma (is_marker_for)

TET2 ERBB3 BIRC3 PREX2 HNRNPH1 HP MTOR CCL2 DNMT3A

2.93e-053011539DOID:684 (is_marker_for)
DiseaseMalignant lymphoma, lymphocytic, intermediate differentiation, diffuse

BIRC3 CCND1 MTOR

7.29e-05161533C0334634
DiseaseGlycodeoxycholate sulfate measurement

SLC10A2 SULT2A1

7.99e-0531532EFO_0022098
Diseasesevere acute respiratory syndrome, COVID-19

SNX4 INPP5D SPEF2 TRPM2 PREX2 CASK NTN4 DMD PARD3 PDZD2

1.20e-0444715310EFO_0000694, MONDO_0100096
Diseaseacute myeloid leukemia (is_marker_for)

TET2 CCND1 CCL2 DNMT3A

1.23e-04491534DOID:9119 (is_marker_for)
Diseaseend stage renal disease (implicated_via_orthology)

GTPBP4 MTOR CCL2

1.46e-04201533DOID:783 (implicated_via_orthology)
Diseasechronic obstructive pulmonary disease (is_marker_for)

FLT1 HP CCL2 CCL7 COL1A1

1.54e-04971535DOID:3083 (is_marker_for)
DiseaseGlycochenodeoxycholate sulfate measurement

SLC10A2 SULT2A1

1.59e-0441532EFO_0022097
DiseaseAngioimmunoblastic Lymphadenopathy

TET2 DNMT3A

1.59e-0441532C0020981
Diseaseglycodeoxycholate 3-sulfate measurement

SLC10A2 SULT2A1

1.59e-0441532EFO_0800385
Diseasestatus epilepticus (implicated_via_orthology)

CCND1 MTOR CX3CL1

1.70e-04211533DOID:1824 (implicated_via_orthology)
DiseaseNephritis, Interstitial

FAN1 CCL2 CCL7

2.55e-04241533C0027707
Diseasegraft-versus-host disease (biomarker_via_orthology)

HSPA1A HSPA1B

2.64e-0451532DOID:0081267 (biomarker_via_orthology)
DiseaseDuchenne and Becker Muscular Dystrophy

CCL2 DMD

2.64e-0451532C3542021
DiseaseBecker Muscular Dystrophy

CCL2 DMD

2.64e-0451532C0917713
DiseaseMajor Depressive Disorder

ERBB3 CCND1 HP MTOR CCL2 HSPA1A HSPA1B

2.88e-042431537C1269683
DiseaseLeft Ventricular Hypertrophy

CKM MTOR COL1A1

2.89e-04251533C0149721
DiseaseMyocardial Ischemia

CTTNBP2 IRF1 CCND1 CCL2 HSPA1A CX3CL1

3.23e-041761536C0151744
Diseaseoral squamous cell carcinoma (is_marker_for)

TET2 BIRC2 BIRC3 HP

3.26e-04631534DOID:0050866 (is_marker_for)
DiseaseAllergic Reaction

HP CCL2 CCL7 CX3CL1

3.26e-04631534C1527304
DiseaseHypersensitivity

HP CCL2 CCL7 CX3CL1

3.47e-04641534C0020517
Diseaseage related macular degeneration (implicated_via_orthology)

CCL2 CCL13

3.95e-0461532DOID:10871 (implicated_via_orthology)
Diseasecrescentic glomerulonephritis (implicated_via_orthology)

MTOR CCL2

3.95e-0461532DOID:13139 (implicated_via_orthology)
DiseaseLeukemia, Myelomonocytic, Chronic

TET2 DNMT3A

3.95e-0461532C0023480
DiseaseMuscular Dystrophy, Duchenne

CCL2 DMD

3.95e-0461532C0013264
DiseaseUnipolar Depression

ERBB3 CCND1 HP MTOR CCL2 HSPA1A HSPA1B

4.23e-042591537C0041696
DiseaseC-C motif chemokine 7 measurement

CCL2 CCL7 CCL13

4.52e-04291533EFO_0008054
Diseaseasthma (is_marker_for)

IRF1 HP CCL2 CCL7 CX3CL1

5.18e-041261535DOID:2841 (is_marker_for)
Diseasetaurochenodeoxycholic acid 3-sulfate measurement

SLC10A2 SULT2A1

5.51e-0471532EFO_0800584
Diseasecolon adenoma (is_marker_for)

TET2 CCND1

5.51e-0471532DOID:0050912 (is_marker_for)
DiseaseSevere Congenital Microcephaly

CASK MFSD2A DNMT3A

5.52e-04311533C3853041
Diseaserenal cell carcinoma (is_marker_for)

FLT1 BIRC2 BIRC3 CCND1 MTOR

5.56e-041281535DOID:4450 (is_marker_for)
Diseaselysophosphatidylcholine 20:4 measurement

MYCBP2 EYA2 TNKS

6.07e-04321533EFO_0010363
Diseasecortical surface area measurement

TET2 USP34 ERBB3 CTTNBP2 MYCBP2 TUT7 EYA1 HNRNPH1 FBXO16 NTN4 MLLT3 EEF1AKMT2 TNKS DIAPH3 PARD3 SDR16C5 PDZD2

6.35e-04134515317EFO_0010736
DiseaseMicrolissencephaly

CASK MFSD2A DNMT3A

6.65e-04331533C1956147
Diseasefamilial hyperlipidemia (is_implicated_in)

CCL2 HSPA1B

7.33e-0481532DOID:1168 (is_implicated_in)
Diseasealcoholic hepatitis (is_marker_for)

CCL2 COL1A1

7.33e-0481532DOID:12351 (is_marker_for)
DiseaseKartagener Syndrome

SPAG1 SPEF2 CFAP221

7.92e-04351533C0022521
Diseaselung disease (biomarker_via_orthology)

IRF1 CCL2 CX3CL1

7.92e-04351533DOID:850 (biomarker_via_orthology)
DiseaseCiliary Dyskinesia, Primary, 1, With Or Without Situs Inversus

SPAG1 SPEF2 CFAP221

7.92e-04351533C4551906
Diseaseposterior thigh muscle fat infiltration measurement

EYA4 EYA1 EYA2

7.92e-04351533EFO_0020934
DiseasePolynesian Bronchiectasis

SPAG1 SPEF2 CFAP221

7.92e-04351533C4317124
Diseaselung non-small cell carcinoma (is_implicated_in)

TET2 ERBB3 BIRC3 IRF1 CCND1

8.08e-041391535DOID:3908 (is_implicated_in)
Diseasepulmonary hypertension (biomarker_via_orthology)

RYR3 CCL2 CX3CL1 COL1A1

8.09e-04801534DOID:6432 (biomarker_via_orthology)
Diseasebreast carcinoma

TET2 NRAP TTC28 IRF1 ADAM29 CHST9 CCND1 CEP192 CPNE5 CCL28 DNAJC1 DMD DNMT3A COL1A1

8.82e-04101915314EFO_0000305
Diseasetongue squamous cell carcinoma (is_marker_for)

ERBB3 BIRC2 CCND1

9.33e-04371533DOID:0050865 (is_marker_for)
Diseasecorneodesmosin measurement

CCL2 CCL13

9.39e-0491532EFO_0801499
Diseasealpha-amylase 1 measurement

AMY2A AMY2B

9.39e-0491532EFO_0801371
DiseaseMajor depression, single episode

HSPA1A HSPA1B

9.39e-0491532C0024517
Diseaseaggressive periodontitis (is_implicated_in)

CCL2 COL1A1

9.39e-0491532DOID:1474 (is_implicated_in)
Diseaseglycochenodeoxycholate 3-sulfate measurement

SLC10A2 SULT2A1

9.39e-0491532EFO_0800384
DiseaseAutism Spectrum Disorders

CTTNBP2 TET3 IQGAP3 DNMT3A

1.02e-03851534C1510586
Diseaseductal carcinoma in situ (is_marker_for)

FLT1 ERBB3 CCND1

1.09e-03391533DOID:0060074 (is_marker_for)
DiseasePeripheral T-Cell Lymphoma

TET2 DNMT3A

1.17e-03101532C0079774
DiseaseEczema

ERBB3 TTC28 INPP5D SPEF2 IRF1 EYA2 DNMT3A

1.21e-033101537HP_0000964
DiseaseMultiple Myeloma

BIRC3 CCND1 CCL2

1.35e-03421533C0026764
DiseaseTumoral calcinosis

CCL2 DMD COL1A1

1.35e-03421533C0263628
DiseaseCalcinosis

CCL2 DMD COL1A1

1.35e-03421533C0006663
DiseaseMicrocalcification

CCL2 DMD COL1A1

1.35e-03421533C0521174
DiseaseMacrocephaly

CACNA1E TET3

1.42e-03111532C0221355
DiseaseLymphoma, Lymphocytic, Intermediate

CCND1 MTOR

1.42e-03111532C0751958
DiseaseComplications of Diabetes Mellitus

SLC10A2 HP

1.42e-03111532C0342257
Diseasedilated cardiomyopathy (is_implicated_in)

EYA4 ANKRD1 DMD

1.45e-03431533DOID:12930 (is_implicated_in)
DiseaseMalignant neoplasm of breast

FLT1 ERBB3 BIRC2 CCND1 GALNT16 HP MTOR N4BP2 NLE1 DHX32 DMD HSPA1B VPS13B DNMT3A

1.45e-03107415314C0006142
DiseaseThyroid carcinoma

CCND1 MTOR CCL2

1.55e-03441533C0549473
Diseaseureteral obstruction (biomarker_via_orthology)

IRF1 MTOR COL1A1

1.65e-03451533DOID:5199 (biomarker_via_orthology)
Diseasecalcium measurement

TET2 CCND1 EYA1 EYA2 MLYCD EEF1D DNAJC1 CTSS DNMT3A TBX2

1.68e-0362815310EFO_0004838
Diseasemacular retinal edema (is_marker_for)

FLT1 CCL2

1.70e-03121532DOID:4449 (is_marker_for)
DiseaseMammary Carcinoma, Human

FLT1 ERBB3 BIRC2 CCND1 GALNT16 HP MTOR HSPA1B DNMT3A

1.74e-035251539C4704874
DiseaseMammary Neoplasms, Human

FLT1 ERBB3 BIRC2 CCND1 GALNT16 HP MTOR HSPA1B DNMT3A

1.74e-035251539C1257931
DiseaseMammary Neoplasms

FLT1 ERBB3 BIRC2 CCND1 GALNT16 HP MTOR HSPA1B DNMT3A

1.78e-035271539C1458155
DiseasePrimary Ciliary Dyskinesia

SPAG1 SPEF2 CFAP221

1.88e-03471533C4551720
Diseaselung non-small cell carcinoma (is_marker_for)

ERBB3 BIRC2 BIRC3 CCND1 PREX2

1.92e-031691535DOID:3908 (is_marker_for)
DiseaseCOVID-19, mortality

TTC28 GALNT16 ZNF12 MFSD2A PDZD2

1.97e-031701535EFO_0004352, MONDO_0100096
Diseaseintracranial aneurysm (biomarker_via_orthology)

CCL2 CTSS

2.01e-03131532DOID:10941 (biomarker_via_orthology)
DiseaseBreast Carcinoma

FLT1 ERBB3 BIRC2 CCND1 GALNT16 HP MTOR HSPA1B DNMT3A

2.05e-035381539C0678222
DiseaseHIV Infections

BIRC2 BIRC3 HP CCL2

2.06e-031031534C0019693
DiseaseHIV Coinfection

BIRC2 BIRC3 HP CCL2

2.06e-031031534C4505456
DiseaseSchizophrenia

ERBB3 CCND1 CSMD2 ADNP HP PIK3C3 MTOR KDM2B CCL2 HSPA1A HSPA1B HOMER2

2.25e-0388315312C0036341
DiseaseKawasaki disease (is_marker_for)

FLT1 HP

2.33e-03141532DOID:13378 (is_marker_for)
Diseaseasthma, body mass index

ERBB3 PIK3C3

2.33e-03141532EFO_0004340, MONDO_0004979
Diseasevascular dementia (biomarker_via_orthology)

FLT1 MTOR

2.33e-03141532DOID:8725 (biomarker_via_orthology)
DiseaseKuhnt-Junius degeneration (is_marker_for)

FLT1 CCL2

2.33e-03141532DOID:10873 (is_marker_for)
Diseaseunipolar depression, sex interaction measurement

SNX4 ADAM29 SCG2

2.37e-03511533EFO_0003761, EFO_0008343
Diseaselymphocyte percentage of leukocytes

TET2 SPAG1 TTC28 STXBP5 IRF1 LRRK1 HNRNPH1 KDM2B CTSS DNMT3A

2.54e-0366515310EFO_0007993
Diseasehepatocellular carcinoma (is_implicated_in)

TET2 BIRC3 CCND1 RYR3 CCL2

2.59e-031811535DOID:684 (is_implicated_in)
Diseasesystemic scleroderma (is_marker_for)

CCL2 CX3CL1 COL1A1

2.65e-03531533DOID:418 (is_marker_for)
Diseasenon-alcoholic fatty liver disease

IFT172 EYA1 EYA2 EXOC3L4 PARD3

2.65e-031821535EFO_0003095
DiseaseNeoplasm of uncertain or unknown behavior of bladder

ERBB3 MTOR

2.68e-03151532C0496930
DiseaseBenign neoplasm of bladder

ERBB3 MTOR

2.68e-03151532C0154017
DiseaseCarcinoma in situ of bladder

ERBB3 MTOR

2.68e-03151532C0154091
Diseasevitamin K-dependent protein C measurement

CNBD2 PARD3

2.68e-03151532EFO_0008318
DiseasePneumonia

CCL2 CCL7 CX3CL1

2.79e-03541533C0032285
DiseaseLobar Pneumonia

CCL2 CCL7 CX3CL1

2.79e-03541533C0032300
DiseasePneumonitis

CCL2 CCL7 CX3CL1

2.79e-03541533C3714636

Protein segments in the cluster

PeptideGeneStartEntry
SAHKDMWLSVVKFLP

ABHD6

81

Q9BV23
EEERNPLKNIKWMTH

AKAP14

56

Q86UN6
PLKNIKWMTHGEFTV

AKAP14

61

Q86UN6
KWKSENITPRMQHDT

ADAM29

271

Q9UKF5
LNKVKHEMDFDAEWL

ADNP

831

Q9H2P0
QDWLHPLMDKVVTFA

EXOC3L4

541

Q17RC7
AKTPIKWMALESIHF

ERBB3

871

P21860
TVKHMWPFICQFIEK

ESYT2

201

A0FGR8
PHNHTVKQWMKVQAA

CCL28

76

Q9NRJ3
KNEQHTVMKLPWDSL

EIF2D

446

P41214
TWNLSNHEKMKAVPV

AIPL1

166

Q9NZN9
PVEIFMNKFKDDHWA

CSMD2

3341

Q7Z408
QKETLAIWPHLSQKM

CACNA1E

1836

Q15878
QHFPVFMNEKEDILW

DNMT3A

846

Q9Y6K1
KTPMDLVLHWQNGTK

ANKRD1

286

Q15327
DPKEKWVQNYMKHLG

CCL13

76

Q99616
KKPTVEGFTHDWMVF

MLLT3

21

P42568
EPHDNENNKWEMIKN

GVINP1

841

Q7Z2Y8
YWDLMNLSEKHDKIP

GTPBP4

416

Q9BZE4
KLSNWEPKDNAMSEH

BIRC3

211

Q13489
NKLKWNLAAMTPHDF

CCND1

146

P24385
EWNKNPDMLFTIHPV

DMXL2

501

Q8TDJ6
HIQTLKKWMAEVDVF

DMD

1056

P11532
LDASKHMWPGDIKAI

AMY2B

211

P19961
PHEMTENCFWIKVNE

DIAPH3

656

Q9NSV4
MPEWVLFHKFSISEN

DHX32

661

Q7L7V1
ASEKNERLLMKPQWH

DNAJC1

206

Q96KC8
GIPIDMWNKFQELHK

FAM204A

71

Q9H8W3
MATNFLAHEKIWFDK

EEF1D

1

P29692
DKSMGQKWEHFITAP

CCDC60

201

Q8IWA6
HFKWEQIPLEQKMTR

GALNT16

266

Q8N428
LMEKSFDVNFKAHLW

SDR16C5

141

Q8N3Y7
HCIDISDMKWQKLNP

RABEPK

221

Q7Z6M1
EEIAAKQHNMPFWRI

EYA3

541

Q99504
WINKEEMIFQIPWKH

IRF1

26

P10914
NEWFKHMNSVPQKPA

NUP107

761

P57740
QDNMKLHKVDFIWIN

NOX5

626

Q96PH1
KGSWVNKFPVEMTHN

SERPIND1

296

P05546
LDASKHMWPGDIKAI

AMY2A

211

P04746
KMNPRQWSHISESAK

CASK

236

O14936
NNPIKKWAKDMNRHF

nan

1066

O00370
HLDAKGSFPWQAKMV

HP

166

P00738
HFTALPTDMKVEWAK

NRAP

901

Q86VF7
HKFTALPEDLKMAWA

NRAP

1386

Q86VF7
PDKMAVFWKNHLKDV

LRRK1

441

Q38SD2
AHVFQIDPNTKKNWM

HOMER2

11

Q9NSB8
KDMAIFWHRKKISPN

MCM3AP

496

O60318
QEWLSHLEKTFAMKD

HPS5

641

Q9UPZ3
KISEAEAVHPVKNWM

MLYCD

211

O95822
KIMHFPTWVDLKGED

DDX1

421

Q92499
RKFGDPVVQSDMKHW

HSPA1B

76

P0DMV9
DMKHWPFQVINDGDK

HSPA1B

86

P0DMV9
RPIMAWFKEINKHNQ

PDZD2

1796

O15018
AVQQDPKHMEAWQYL

PEX5

361

P50542
PEVGLDNKMKLFLHW

FAM205C

251

A6NFA0
KSWIKIMQRAHENPN

DNAH8

1526

Q96JB1
KMHIKSPTDFEWLKQ

DNAH8

1771

Q96JB1
EQGAKKHAMPFWRIS

EYA1

561

Q99502
MHIIKAQPFKDRCEW

HACE1

516

Q8IYU2
PECPVMHDSKNWKNL

HERC6

486

Q8IVU3
MHDSKNWKNLVVPFA

HERC6

491

Q8IVU3
SHLRGPFKEVQWNKM

MED17

616

Q9NVC6
FKSNNVEMDWVLKHT

HNRNPH1

86

P31943
KQRPADTAFWVQHDM

IQGAP3

661

Q86VI3
PKEAVLMFVHNQDWE

IFT172

1171

Q9UG01
SWAEPQLKAMKALQH

PROSER1

46

Q86XN7
WSMLPDVIDDFHLKQ

MFSD2A

416

Q8NA29
SKVDIPAHWSDMKQQ

PARP14

1601

Q460N5
PHIKIEMKNATLAWD

ABCC5

486

O15440
QAHKEENWALPVMYA

PCID2

96

Q5JVF3
VSKFMAIQKALQPDW

QTRT2

126

Q9H974
WLEPNKSIFKQMKTH

FRMD3

86

A2A2Y4
DPDEIMWFKKLHLVN

ACOX1

81

Q15067
MWFKKLHLVNFVEPV

ACOX1

86

Q15067
SFQDHAVWKPLMKVL

ARMC8

421

Q8IUR7
EEEQAAKKHNMPFWR

EYA4

606

O95677
NMWPQHLKEKQTEAT

KDM2B

201

Q8NHM5
PVAWRMDSEKHGQSK

BCLAF3

46

A2AJT9
KVDFLWHPEVNGSMK

CASD1

131

Q96PB1
LQEEMKLCSWFKHLP

COG1

311

Q8WTW3
AKKWNEEHLHTVNPM

DNAH3

336

Q8TD57
ADPKQKWVQDSMDHL

CCL2

76

P13500
SPWDFMRKNKAEHIT

CTTNBP2

1071

Q8WZ74
TQMPKWKESSHQGAA

CDHR3

806

Q6ZTQ4
WMQKHKIPLDASVLD

EEF1AKMT2

71

Q5JPI9
QSALDRMKNPVTKHW

MACC1

811

Q6ZN28
DSPIDFHLQSWMNNK

CEP192

156

Q8TEP8
FHLQSWMNNKEPKIV

CEP192

161

Q8TEP8
TMFRIPWKHAGKQDF

IRF9

36

Q00978
KEMLANSWNCLPKHL

KLHDC2

376

Q9Y2U9
HLSAKKLPNWQMEVS

KLF10

451

Q13118
IWEKNLKFVMLHNLE

CTSS

51

P25774
WKGMKQFLPAKAVDH

DCBLD2

576

Q96PD2
RKFGDPVVQSDMKHW

HSPA1A

76

P0DMV8
DMKHWPFQVINDGDK

HSPA1A

86

P0DMV8
ADPTQKWVQDFMKHL

CCL7

76

P80098
PFEQGIWKKHYIQMV

FBXO16

146

Q8IX29
SDFHLFKEGIKPMWE

EIF4E2

111

O60573
PLSMIFKLQNAFWEH

PPP1R13L

371

Q8WUF5
HKTEVMKNTLNPVWQ

CPNE5

216

Q9HCH3
VPIKMQVKHWPSEQD

PRAP1

26

Q96NZ9
HPMVGKWLEKQEQDE

PARD3

226

Q8TEW0
VSIGMFVNHKWPQKA

SLC10A2

176

Q12908
KEMQKPQWYRHTFEE

MTOR

226

P42345
LKWQVHLGKDPMSFK

CFAP221

376

Q4G0U5
EEQGAKKHNMPFWRI

EYA2

506

O00167
VKMKWQFEHTKPTPF

MT-ND2

311

P03891
VKGPNDRLSHKQMIW

FAN1

976

Q9Y2M0
IKKSVNPQWNHTFMF

SYTL5

631

Q8TDW5
WDVKAQKLAMDLPGH

NLE1

441

Q9NVX2
DTMTHNNFWLKKIEI

SNX4

46

O95219
NNLIPYKLMHDWKEL

SPEF2

451

Q9C093
KDIEFMIGHKPNIFW

SLC6A19

516

Q695T7
HRKNPIEKNLQMWEE

EPRS1

311

P07814
MDKFPFNWKLKSHIL

TMEM132B

111

Q14DG7
KVNQWALESFAKMIP

TOGARAM2

821

Q6ZUX3
EEIFKKAGHPFMWNQ

CKM

261

P06732
IVNMKSFVQHWKPSL

NTN4

601

Q9HB63
EMRAHQDKWAEKPAF

ARHGAP17

236

Q68EM7
MGPAHWEKIEAINQA

FAM98A

196

Q8NCA5
EWAFESEPLFLQHMK

POGZ

566

Q7Z3K3
FRQGMHDLKVWPNVE

PIK3C3

136

Q8NEB9
YETQQWPERKLKHMQ

SCG2

151

P13521
LKSLTSHDPMKQWEV

INPP5D

881

Q92835
FSNGIKKAALMHKWP

MYCBP2

341

O75592
HKLFPETWTAEKIMQ

NDUFAF4

126

Q9P032
LMHSKGDAKWIQSVP

SULT2A1

56

Q06520
LWNLAHVKMEPQESE

SUPT7L

336

O94864
SHGDKTSNPEVLKWM

FAM13C

316

Q8NE31
FSELMKEPILWKHGN

MROH2B

1286

Q7Z745
IMWNKAIELSSKSHP

STXBP5

181

Q5T5C0
WKNFADLEKNPEMVT

RPTOR

1096

Q8N122
KLSNWEPKDDAMSEH

BIRC2

226

Q13490
HPIFSFWDKKMQSRV

CNBD2

56

Q96M20
FSNMNWPVDIHPLNK

CHST9

146

Q7L1S5
KNPKDKRHVWFGESM

COL1A1

1316

P02452
PDHAIQWDKSMCVKN

CNOT11

306

Q9UKZ1
KINAAWFKNMPHLKV

TLR8

301

Q9NR97
WFKNMPHLKVLDLEF

TLR8

306

Q9NR97
KRWNSLPSENHKEMA

TOMM34

156

Q15785
HLPSKMKVWQDDSIN

SUN5

121

Q8TC36
SIQWSFFHKKEMEPI

VSIG1

56

Q86XK7
HWKFPQEQNKMKPEF

USP17L4

436

A6NCW7
THNTWKAMEGIFIKP

SDF2L1

196

Q9HCN8
GEQWMAKPVAFHKLK

TBX2

196

Q13207
WIQDFKTHFLDPKLM

THEM4

86

Q5T1C6
KMPLKLLTNHYEQCW

RYR3

2501

Q15413
TQWDPKKHVQEMPTD

TRPM2

111

O94759
MDLWQFTPLHEAASK

TNKS

431

O95271
PLQAWHPAKEMISKQ

SPAG1

591

Q07617
NKWFVCMAKTPEEKH

PREX2

336

Q70Z35
QPNHGLALWEAKMKQ

TET3

1701

O43151
NWTLLKSDMNKPHLI

TTLL6

711

Q8N841
KEFMDRHGIPTAQWK

GART

111

P22102
LEQEKEPWNLKTHDM

ZNF730

56

Q6ZMV8
DEKVQAVHNLKMFWQ

TTC28

2351

Q96AY4
DQAPNSHVKYVWKML

VPS13B

3846

Q7Z7G8
HWKFPQEQNKMKPEF

USP17L8

436

P0C7I0
PKAMKSILDHLNWVF

SCN11A

1391

Q9UI33
KWPFFQEAQKLQAMH

SRY

106

Q05066
VFVNHMEEKPYKWNG

ZNF12

231

P17014
FIHSKEKPTMLQWIE

USP34

2316

Q70CQ2
FWDQPDNIAHMKAKG

UGT2B28

396

Q9BY64
QPAWMNDSHKDQSKR

TUT7

86

Q5VYS8
EAAHKWSLPEMVSKE

FLT1

56

P17948
SMNEPKHGLALWEAK

TET2

1906

Q6N021
PDKREENDQSTHKWM

YEATS2

221

Q9ULM3
ECMWPQGVLVKHSKN

TMEM39B

376

Q9GZU3
DPKEQWVKDAMQHLD

CX3CL1

76

P78423
IDNTNLHAWEMKPYA

N4BP2L1

116

Q5TBK1
EMLPLLDHWNTQTKK

N4BP2

1476

Q86UW6
KIMNEHLYKQAWEAD

NEB

1986

P20929
EAWDKDKTQVHIMPD

NEB

3211

P20929
PKIMWSLHIAKVQSD

NEB

3301

P20929