Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	titin binding	OBSCN CAMK2D	4.05e-04	14	43	2	GO:0031432
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	OBSCN PLEKHG7 SGSM2 ARHGEF15 SIPA1L3 TBCD	7.14e-04	507	43	6	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	OBSCN PLEKHG7 SGSM2 ARHGEF15 SIPA1L3 TBCD	7.14e-04	507	43	6	GO:0030695
GeneOntologyCellularComponent	cell-cell junction	OBSCN FAT2 DSG1 SHROOM2 CAMK2D SIPA1L3 TBCD	1.59e-04	591	42	7	GO:0005911
MousePheno	abnormal sarcoplasmic reticulum morphology	OBSCN CAMK2D RYR1	2.25e-05	23	34	3	MP:0004088
Domain	DH_1	OBSCN PLEKHG7 ARHGEF15	3.56e-04	63	41	3	PS00741
Domain	RhoGEF	OBSCN PLEKHG7 ARHGEF15	4.46e-04	68	41	3	SM00325
Domain	DH_2	OBSCN PLEKHG7 ARHGEF15	4.85e-04	70	41	3	PS50010
Domain	RhoGEF	OBSCN PLEKHG7 ARHGEF15	4.85e-04	70	41	3	PF00621
Domain	DH-domain	OBSCN PLEKHG7 ARHGEF15	5.06e-04	71	41	3	IPR000219
Domain	-	OBSCN PLEKHG7 ARHGEF15	5.06e-04	71	41	3	1.20.900.10
Domain	GDS_CDC24_CS	OBSCN ARHGEF15	3.31e-03	39	41	2	IPR001331
Domain	Ser/Thr_kinase_AS	OBSCN CILK1 CAMK2D KSR2	7.61e-03	357	41	4	IPR008271
Domain	S_TKc	OBSCN CILK1 CAMK2D KSR2	7.76e-03	359	41	4	SM00220
Domain	PROTEIN_KINASE_ST	OBSCN CILK1 CAMK2D KSR2	7.99e-03	362	41	4	PS00108
Domain	Pkinase	OBSCN CILK1 CAMK2D KSR2	9.52e-03	381	41	4	PF00069
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	OBSCN CRYBG2 ATG9A SRCAP RHBDF2 ZDHHC8 SGSM2 RYR1 SIPA1L3 TBCD KSR2 SEC16A	6.16e-09	1105	43	12	35748872
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	OBSCN AUTS2 ZNF704 CILK1 RHBDF2 SHROOM2 SGSM2 SIPA1L3 TBCD XPNPEP3 KSR2	1.39e-06	1489	43	11	28611215
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	OBSCN MNT SGSM2 RYR1 TBCD	6.70e-06	214	43	5	22199357
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	AUTS2 TAB2 ARHGEF15 SIPA1L3 SEC16A	8.54e-06	225	43	5	12168954
Pubmed	Deregulation of the protocadherin gene FAT1 alters muscle shapes: implications for the pathogenesis of facioscapulohumeral dystrophy.	PAX3 RYR1	5.35e-05	9	43	2	23785297
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	TRIM66 SRCAP SEC16A	2.94e-04	104	43	3	9205841
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	OBSCN TAB2 FAM168B SRCAP SHROOM2 CAMK2D SEC16A	3.39e-04	1084	43	7	11544199
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	CILK1 TRIM66 FAT2 ARHGEF15 SIPA1L3	3.46e-04	493	43	5	15368895
Pubmed	Genomic variants in an inbred mouse model predict mania-like behaviors.	OBSCN KSR2	3.72e-04	23	43	2	29768498
Pubmed	BCOR modulates transcriptional activity of a subset of glucocorticoid receptor target genes involved in cell growth and mobility.	GSE1 SEC16A	4.05e-04	24	43	2	33722704
Pubmed	A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.	RP1 DSG1 CAMK2D SGSM2	4.18e-04	284	43	4	29459677
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	TAB2 DSG1 AQR XPNPEP3 SEC16A	5.74e-04	551	43	5	34728620
Pubmed	Distinct transcriptomic changes in E14.5 mouse skeletal muscle lacking RYR1 or Cav1.1 converge at E18.5.	PAX3 RYR1	5.93e-04	29	43	2	29543863
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	AUTS2 TAB2 GSE1 DSG1 MNT AQR TBCD	6.31e-04	1203	43	7	29180619
Pubmed	Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.	OBSCN B9D1 PAX3 DSG1 SEC16A	6.38e-04	564	43	5	21565611
Pubmed	A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs.	SRCAP MNT	8.66e-04	35	43	2	20946988
Pubmed	A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.	TAB2 XPNPEP3 SEC16A	1.07e-03	162	43	3	14743216
Pubmed	Spatially dependent dynamic MAPK modulation by the Nde1-Lis1-Brap complex patterns mammalian CNS.	PAX3 KSR2	1.19e-03	41	43	2	23673330
Cytoband	9p13.3	KIF24 PIGO	2.28e-03	75	43	2	9p13.3
Cytoband	2q35	PAX3 ATG9A	2.52e-03	79	43	2	2q35
Cytoband	17p13.3	MNT SGSM2	3.12e-03	88	43	2	17p13.3
Cytoband	Ensembl 112 genes in cytogenetic band chr17p13	MNT SGSM2 ARHGEF15	4.19e-03	346	43	3	chr17p13
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	OBSCN ARHGEF15	5.70e-03	66	31	2	722
Coexpression	GSE45739_UNSTIM_VS_ACD3_ACD28_STIM_NRAS_KO_CD4_TCELL_DN	AUTS2 CHST12 GSE1 RHBDF2 CD248 SIPA1L3	8.57e-07	199	43	6	M9885
Drug	N6-methyladenosine [1867-73-8]; Down 200; 14.2uM; MCF7; HT_HG-U133A	B9D1 TRIM66 FAM168B SRCAP SGSM2 AQR XPNPEP3	8.08e-08	197	43	7	5332_DN
Drug	15d-PGJ2; Down 200; 10uM; HL60; HT_HG-U133A	TRIM66 CHST12 GSE1 RHBDF2 MNT	2.45e-05	184	43	5	2691_DN
Drug	Quercetine dihydrate [6151-25-3]; Down 200; 11.8uM; HL60; HT_HG-U133A	CHST12 SRCAP RHBDF2 PIGO TBCD	2.93e-05	191	43	5	2499_DN
Drug	Retrorsine [480-54-6]; Down 200; 11.4uM; HL60; HT_HG-U133A	ATG9A SRCAP RHBDF2 SGSM2 TBCD	3.08e-05	193	43	5	2129_DN
Drug	Betahistine mesylate [54856-23-4]; Up 200; 17.2uM; MCF7; HT_HG-U133A	AUTS2 POM121L2 ATP10B KEL SRCAP	3.24e-05	195	43	5	2833_UP
Drug	0198306-0000 [212631-61-3]; Down 200; 10uM; PC3; HT_HG-U133A	CRYBG2 SRCAP SHROOM2 SGSM2 XPNPEP3	3.40e-05	197	43	5	7069_DN
Drug	Cyclopenthiazide [742-20-1]; Up 200; 10.6uM; HL60; HT_HG-U133A	B9D1 KEL CD248 PIGO TBCD	3.48e-05	198	43	5	2905_UP
Drug	Thiamphenicol [15318-45-3]; Down 200; 11.2uM; PC3; HT_HG-U133A	B9D1 CRYBG2 SRCAP SGSM2 XPNPEP3	3.48e-05	198	43	5	1826_DN
Drug	Ranitidine hydrochloride [66357-59-3]; Up 200; 11.4uM; MCF7; HT_HG-U133A	ATP10B KEL CRYBG2 ATG9A SRCAP	3.48e-05	198	43	5	5425_UP
Drug	Ketoprofen [22071-15-4]; Up 200; 15.8uM; MCF7; HT_HG-U133A	ATP10B CRYBG2 PAX3 SRCAP RYR1	3.48e-05	198	43	5	4751_UP
Drug	Moxonidine [75438-57-2]; Up 200; 16.6uM; HL60; HT_HG-U133A	B9D1 KEL CRYBG2 SRCAP TBCD	3.56e-05	199	43	5	2923_UP
Drug	butirosin A from Bacillus vitellinus; Down 200; 10uM; PC3; HG-U133A	POM121L2 SHROOM2 ARHGEF15 AQR SIPA1L3	3.65e-05	200	43	5	666_DN
Disease	Kunitz-type protease inhibitor 2 measurement	RYR1 SIPA1L3	8.42e-05	10	41	2	EFO_0008200
Disease	information processing speed	PAX3 DSG1 SIPA1L3	2.27e-04	85	41	3	EFO_0004363

Protein segments in the cluster

Peptide	Gene	Start	Entry
PSHPHPPHSLTTFLR	nan	136	P0DMU3
HLPGIPPNHAPLVTT	CD248	546	Q9HCU0
HPVPTPHHTVPSLIS	GSE1	456	Q14687
PHPPSIGHPAVVLTS	ARHGEF15	251	O94989
RPLHLHIIPTEPFPT	AQR	1326	O60306
APVPEVARPTHHPVS	ATP10B	1356	O94823
PPPPFHGSISRLHQI	PABIR3	66	Q6P4D5
PSHSSLPVGRRHPPV	H1-8	41	Q8IZA3
GHAPFLPSTPPVHTE	KSR2	371	Q6VAB6
GPLPPSAHRHSTPVV	FAT2	4201	Q9NYQ8
HTFTPFPHAIPPTAI	AUTS2	541	Q8WXX7
GKVHPLTSHPPNIPF	KIF24	606	Q5T7B8
LAPATPPIGHITVHP	MNT	481	Q99583
PVVSGHPPISPHFGT	DSG1	791	Q02413
STVHRPQPLPPSTVH	PAX3	326	P23760
PSPVTHSPLLHPRGF	OBSCN	6811	Q5VST9
PGTVPRVPSHFSRLP	ATG9A	791	Q7Z3C6
LVPAGHSPPASHLPR	CRYBG2	241	Q8N1P7
LTHPAKQPVVPTHPG	CRYBG2	366	Q8N1P7
HTALTLGAPHPPPRD	IFITM5	21	A6NNB3
VHVPFSPGRHKRTIP	B9D1	106	Q9UPM9
GVTTSLRPPHHFSPP	RYR1	1766	P21817
PVGHPHLTFIPTTPR	PRRT3	146	Q5FWE3
LLTAHSPTPVAPHPV	FAM168B	161	A1KXE4
HFHRSGSPTVPIKPP	CAMK2D	466	Q13557
VPPPRHLSLTHPVVA	RP1	21	P56715
TGSPHLTTVHRPLPP	PHACTR3	276	Q96KR7
TPTSLHIHGVPPPVL	TAB2	191	Q9NYJ8
VHHSVIPPDRPPGAS	SGSM2	521	O43147
PVHSHLSLERGPPTP	SIPA1L3	1686	O60292
SLPPPTVGQSPRHHL	SHROOM2	506	Q13796
PGHPLLLAPTSSHVP	SRCAP	1521	Q6ZRS2
TGFIFPPHHHPTIPT	POM121L2	681	Q96KW2
PHPGRPFFHTQPRST	CILK1	591	Q9UPZ9
LHTSFSRPHTGPPLP	CHST12	36	Q9NRB3
ASPPVSLHHRPLGPA	nan	81	Q8TAT8
SVPHFPTPSILHQGP	SEC16A	246	O15027
PPVTFTGIPVSPTHH	ZNF704	336	Q6ZNC4
LGQPSPFTHPHLLRP	XPNPEP3	46	Q9NQH7
PFTHPHLLRPGEVTP	XPNPEP3	51	Q9NQH7
GPPTPHRSIFAPHAL	ZDHHC8	456	Q9ULC8
HFLPSPTLRHPSPQG	PLEKHG7	156	Q6ZR37
QHSHVPREPPVSLPF	PIGO	86	Q8TEQ8
LTLLHFDSPPIPHVP	TBCD	926	Q9BTW9
VPPPSIHPAHSFRQP	TRIM66	336	O15016
HAPHPPLTPGVLSLT	RHBDF2	206	Q6PJF5
LGPHPASPHTPVIQI	KEL	211	P23276
PPHLRVHGPLSSTPA	KEL	696	P23276