Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	WD40	DCAF13 PLAA TBL1XR1 TBL1Y EML3 BTRC DENND3 DYNC1I1 WDFY1 PAFAH1B1 GNB5	1.51e-11	259	44	11	PF00400
Domain	WD40	DCAF13 PLAA TBL1XR1 TBL1Y EML3 BTRC DENND3 DYNC1I1 WDFY1 PAFAH1B1 GNB5	2.18e-11	268	44	11	SM00320
Domain	WD40_repeat	DCAF13 PLAA TBL1XR1 TBL1Y EML3 BTRC DENND3 DYNC1I1 WDFY1 PAFAH1B1 GNB5	2.56e-11	272	44	11	IPR001680
Domain	WD_REPEATS_1	DCAF13 PLAA TBL1XR1 TBL1Y EML3 BTRC DENND3 DYNC1I1 WDFY1 PAFAH1B1 GNB5	3.24e-11	278	44	11	PS00678
Domain	WD_REPEATS_2	DCAF13 PLAA TBL1XR1 TBL1Y EML3 BTRC DENND3 DYNC1I1 WDFY1 PAFAH1B1 GNB5	3.36e-11	279	44	11	PS50082
Domain	WD_REPEATS_REGION	DCAF13 PLAA TBL1XR1 TBL1Y EML3 BTRC DENND3 DYNC1I1 WDFY1 PAFAH1B1 GNB5	3.36e-11	279	44	11	PS50294
Domain	WD40_repeat_dom	DCAF13 PLAA TBL1XR1 TBL1Y EML3 BTRC DENND3 DYNC1I1 WDFY1 PAFAH1B1 GNB5	6.58e-11	297	44	11	IPR017986
Domain	-	DCAF13 PLAA TBL1XR1 TBL1Y EML3 BTRC DENND3 DYNC1I1 WDFY1 PAFAH1B1 GNB5	2.23e-10	333	44	11	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	DCAF13 PLAA TBL1XR1 TBL1Y EML3 BTRC DENND3 DYNC1I1 WDFY1 PAFAH1B1 GNB5	2.37e-10	335	44	11	IPR015943
Domain	WD40_repeat_CS	DCAF13 TBL1XR1 TBL1Y BTRC DENND3 WDFY1 PAFAH1B1 GNB5	4.03e-09	164	44	8	IPR019775
Domain	G-protein_beta_WD-40_rep	TBL1XR1 TBL1Y BTRC WDFY1 PAFAH1B1 GNB5	4.57e-08	85	44	6	IPR020472
Domain	LisH	TBL1XR1 TBL1Y PAFAH1B1	1.01e-06	9	44	3	PF08513
Domain	LisH	TBL1XR1 TBL1Y PAFAH1B1	3.84e-05	28	44	3	IPR006594
Domain	LisH	TBL1XR1 TBL1Y PAFAH1B1	3.84e-05	28	44	3	SM00667
Domain	LISH	TBL1XR1 TBL1Y PAFAH1B1	3.84e-05	28	44	3	PS50896
Domain	Peptidase_S1A	HGF PROZ CFI	2.38e-03	113	44	3	IPR001314
Domain	TRYPSIN_DOM	HGF PROZ CFI	2.51e-03	115	44	3	PS50240
Domain	Tryp_SPc	HGF PROZ CFI	2.63e-03	117	44	3	SM00020
Domain	Trypsin	HGF PROZ CFI	2.89e-03	121	44	3	PF00089
Domain	Trypsin_dom	HGF PROZ CFI	2.89e-03	121	44	3	IPR001254
Domain	Peptidase_S1_PA	HGF PROZ CFI	3.03e-03	123	44	3	IPR009003
Domain	Znf_FYVE	RNF34 WDFY1	3.61e-03	38	44	2	IPR000306
Domain	ZF_FYVE	RNF34 WDFY1	4.00e-03	40	44	2	PS50178
Domain	Znf_FYVE_PHD	RNF34 WDFY1 GNB5	5.00e-03	147	44	3	IPR011011
Pubmed	WD40 repeat propellers define a ubiquitin-binding domain that regulates turnover of F box proteins.	PLAA BTRC PAFAH1B1	8.88e-07	14	48	3	21070969
Pubmed	Mutually exclusive cytoplasmic dynein regulation by NudE-Lis1 and dynactin.	DYNC1I1 PAFAH1B1	1.12e-05	4	48	2	21911489
Pubmed	NudC associates with Lis1 and the dynein motor at the leading pole of neurons.	DYNC1I1 PAFAH1B1	1.12e-05	4	48	2	11734602
Pubmed	Functional interplay between LIS1, NDE1 and NDEL1 in dynein-dependent organelle positioning.	DYNC1I1 PAFAH1B1	1.12e-05	4	48	2	20048338
Pubmed	A Cdk5-dependent switch regulates Lis1/Ndel1/dynein-driven organelle transport in adult axons.	DYNC1I1 PAFAH1B1	1.12e-05	4	48	2	22114287
Pubmed	The ZNF75 zinc finger gene subfamily: isolation and mapping of the four members in humans and great apes.	ZNF75D ZNF75CP	1.12e-05	4	48	2	8661144
Pubmed	Hepatic deficiency in transcriptional cofactor TBL1 promotes liver steatosis and hypertriglyceridemia.	TBL1XR1 TBL1Y	1.86e-05	5	48	2	21459324
Pubmed	Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function.	DYNC1I1 PAFAH1B1	1.86e-05	5	48	2	21652625
Pubmed	LIS1 regulates osteoclast formation and function through its interactions with dynein/dynactin and Plekhm1.	DYNC1I1 PAFAH1B1	1.86e-05	5	48	2	22073305
Pubmed	Structure of the MeCP2-TBLR1 complex reveals a molecular basis for Rett syndrome and related disorders.	TBL1XR1 TBL1Y	2.79e-05	6	48	2	28348241
Pubmed	LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dynein.	DYNC1I1 PAFAH1B1	2.79e-05	6	48	2	18784752
Pubmed	Sequential phosphorylation of NDEL1 by the DYRK2-GSK3β complex is critical for neuronal morphogenesis.	DYNC1I1 PAFAH1B1	2.79e-05	6	48	2	31815665
Pubmed	Opposing effects of Ndel1 and alpha1 or alpha2 on cytoplasmic dynein through competitive binding to Lis1.	DYNC1I1 PAFAH1B1	2.79e-05	6	48	2	19622634
Pubmed	Nudel functions in membrane traffic mainly through association with Lis1 and cytoplasmic dynein.	DYNC1I1 PAFAH1B1	3.90e-05	7	48	2	14970193
Pubmed	Zbtb7c is a molecular 'off' and 'on' switch of Mmp gene transcription.	TBL1XR1 TBL1Y	3.90e-05	7	48	2	27646874
Pubmed	A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system.	DYNC1I1 PAFAH1B1	3.90e-05	7	48	2	11163259
Pubmed	The nuclear receptor corepressor deacetylase activating domain is essential for repression by thyroid hormone receptor.	TBL1XR1 TBL1Y	3.90e-05	7	48	2	15695367
Pubmed	Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor.	TBL1XR1 TBL1Y	5.19e-05	8	48	2	23770565
Pubmed	A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma.	TBL1XR1 TBL1Y	5.19e-05	8	48	2	16127449
Pubmed	Linking cytoplasmic dynein and transport of Rab8 vesicles to the midbody during cytokinesis by the doublecortin domain-containing 5 protein.	DYNC1I1 PAFAH1B1	6.67e-05	9	48	2	22159412
Pubmed	A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors.	TBL1XR1 TBL1Y	8.33e-05	10	48	2	14980219
Pubmed	Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells.	DYNC1I1 PAFAH1B1	1.02e-04	11	48	2	18331715
Pubmed	Screening of hepatocyte proteins binding to F protein of hepatitis C virus by yeast two-hybrid system.	CFI PCNX4	1.22e-04	12	48	2	16237761
Pubmed	BICD2, dynactin, and LIS1 cooperate in regulating dynein recruitment to cellular structures.	DYNC1I1 PAFAH1B1	1.68e-04	14	48	2	22956769
Pubmed	An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo.	CLEC4C SCN5A	2.81e-04	18	48	2	31666509
Pubmed	Abnormal epidermal differentiation and impaired epithelial-mesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130.	HGF BTRC	3.49e-04	20	48	2	12702649
Pubmed	CRL4AMBRA1 is a master regulator of D-type cyclins.	BTRC PAFAH1B1	7.92e-04	30	48	2	33854235
Pubmed	eXPRESSION: an in silico tool to predict patterns of gene expression.	DYNC1I1 SCN5A	1.08e-03	35	48	2	15939374
GeneFamily	WD repeat domain containing	DCAF13 PLAA TBL1XR1 TBL1Y EML3 BTRC DENND3 DYNC1I1 WDFY1 PAFAH1B1 GNB5	1.47e-12	262	35	11	362
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Dendritic-dendritic_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CLEC4C ZNF568 DENND3 DYNC1I1 SCN5A	1.70e-06	186	48	5	75b1f342be5d6dbe0e7acd924a0ca75964f6bab0
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs-\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CLEC4C ZNF568 DENND3 DYNC1I1 SCN5A	1.70e-06	186	48	5	0c3d195077de7b4c354c127a26116438aef29244
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CLEC4C ZNF568 DENND3 DYNC1I1 SCN5A	1.70e-06	186	48	5	a558fd00053e7dd6216b01dc8e650c30cee451f1
Disease	sensory system disease (implicated_via_orthology)	TBL1XR1 TBL1Y	6.22e-06	3	43	2	DOID:0050155 (implicated_via_orthology)
Disease	myopia (is_implicated_in)	HGF VDR	2.46e-04	16	43	2	DOID:11830 (is_implicated_in)
Disease	vitiligo (is_implicated_in)	HGF VDR	4.28e-04	21	43	2	DOID:12306 (is_implicated_in)
Disease	Seckel syndrome	CEP152 ORC6	4.70e-04	22	43	2	C0265202
Disease	trans fatty acid measurement, trans/trans-18:2 fatty acid measurement	OR6N2 CYTIP	5.61e-04	24	43	2	EFO_0006821, EFO_0006826
Disease	Behcet's disease (is_implicated_in)	PROZ VDR	1.27e-03	36	43	2	DOID:13241 (is_implicated_in)
Disease	gait measurement	SPATA31E1 ZNF568 BTRC	1.37e-03	150	43	3	EFO_0007680

Protein segments in the cluster

Peptide	Gene	Start	Entry
NESFTMDDMSWTCGN	VDR	276	P11473
KTMFICKSSWSMREA	CFI	136	P05156
LEIMSTCSSKWMSVQ	CEP152	1071	O94986
MMQSGLSRELFESWC	CPSF3	331	Q9UKF6
GTDMWEKNDQSCEIM	BCAR3	726	O75815
MVTCSKDRSIAVWDM	BTRC	396	Q9Y297
SCSMDGMVLVWNVST	DENND3	1006	A2RUS2
MCGSDEMNIRLWKAN	DCAF13	341	Q9NV06
SMSCSDKMARWNVLG	ADAT1	296	Q9BUB4
SSDSGRSMKWSARAM	PGBD4	66	Q96DM1
SGGCDKKAMVWDMRS	GNB5	256	O14775
RDKTIKMWDVSTGMC	PAFAH1B1	316	P43034
CWRFDEMTQTMDKGF	MMP27	396	Q9H306
MSRGQCTALISASWM	OR4D11	136	Q8NGI4
LWGETCTNAVSDMMV	HIPK4	441	Q8NE63
TDGKMCSWSLDMLST	DYNC1I1	411	O14576
CSWSLDMLSTPQESM	DYNC1I1	416	O14576
WRTSCMPSSKMKEMS	PCNX4	916	Q63HM2
TRSGLTCSMWDKNME	HGF	406	P14210
NFVKWSSQGMLRMSC	HSPA12B	436	Q96MM6
LSGSWDEQMECSKVM	OSBP2	746	Q969R2
MASNTDMRWDLEACK	FAM170B	156	A6NMN3
MTTTLCAKMAAACWT	OR6N2	136	Q8NGY6
SAEVEMLCDQAWGSM	CCDC3	76	Q9BQI4
CKSWLSSMTMDSEDG	CYTIP	246	O60759
AVEALMSMSCSWKSD	KLF10	41	Q13118
MLSVWDCSRGMKLAE	EML3	386	Q32P44
SWSRVMCMLKGRAST	ENPP6	406	Q6UWR7
CIAATGMDMWSTQDL	CLDN18	21	P56856
RMSSWATCGMRKTSL	TRMT13	366	Q9NUP7
ETMWDCMEVSGQSLC	SCN5A	901	Q14524
LRMWIRGMKSEHSSC	TENM1	121	Q9UKZ4
RQFMDCMADKAWTIS	SPATA31E1	1306	Q6ZUB1
SSAVMCLDLAASWMK	ORC6	46	Q9Y5N6
CERSSVAAMHWMDGS	PROZ	341	P22891
PLMSMDSWFSCDSKI	STARD9	1331	Q9P2P6
SCSDDMTLKIWSMKQ	TBL1XR1	366	Q9BZK7
MQSWTKSQKNCSVMG	CLEC4C	101	Q8WTT0
MMERKAWCSQESALS	ZNF568	21	Q3ZCX4
TSMWASCCGLLNEVM	RNF34	6	Q969K3
GLSKWRMMSLSQSRS	RIPK2	166	O43353
SQSGSRMEDWKMKDT	ZNF521	231	Q96K83
MSGVMCLKASDTWAS	WASH4P	1	A8MWX3
CLNSHMGAMWETNRS	ZNF75CP	11	Q92670
MGAMWETNRSVKENS	ZNF75CP	16	Q92670
DKCMMTLQGHTAAVW	PLAA	141	Q9Y263
SCSDDMTLKIWSMKQ	TBL1Y	376	Q9BQ87
MGAMWETSGSVKENS	ZNF75D	16	P51815
WSTATMGDQFIMLSC	VSIG10L2	421	P0DP72
KCVSWMCTRSGNMLG	WDFY1	136	Q8IWB7