Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	chromatin insulator sequence binding	ZFX ZFY	2.66e-05	7	23	2	GO:0043035
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	ZC3H12B CHD6 POLN POP1 DDX10	7.18e-04	645	23	5	GO:0140640
Domain	Zfx_Zfy_act	ZFX ZFY	3.97e-06	3	22	2	PF04704
Domain	Transcrp_activ_Zfx/Zfy-dom	ZFX ZFY	3.97e-06	3	22	2	IPR006794
Domain	Zinc_finger_PHD-type_CS	TRIM66 NSD3	2.63e-03	65	22	2	IPR019786
Domain	PHD	TRIM66 NSD3	3.49e-03	75	22	2	PF00628
Domain	Znf_PHD-finger	TRIM66 NSD3	3.86e-03	79	22	2	IPR019787
Domain	PHD	TRIM66 NSD3	4.87e-03	89	22	2	SM00249
Domain	Znf_PHD	TRIM66 NSD3	5.09e-03	91	22	2	IPR001965
Domain	ZF_PHD_2	TRIM66 NSD3	5.53e-03	95	22	2	PS50016
Domain	ZF_PHD_1	TRIM66 NSD3	5.65e-03	96	22	2	PS01359
Domain	Helicase_C	CHD6 DDX10	6.97e-03	107	22	2	PF00271
Domain	HELICc	CHD6 DDX10	6.97e-03	107	22	2	SM00490
Domain	Helicase_C	CHD6 DDX10	7.10e-03	108	22	2	IPR001650
Domain	HELICASE_CTER	CHD6 DDX10	7.22e-03	109	22	2	PS51194
Domain	HELICASE_ATP_BIND_1	CHD6 DDX10	7.22e-03	109	22	2	PS51192
Domain	DEXDc	CHD6 DDX10	7.22e-03	109	22	2	SM00487
Domain	Helicase_ATP-bd	CHD6 DDX10	7.35e-03	110	22	2	IPR014001
Domain	zf-C2H2	RLF ZNF277 ZFX ZFY	8.07e-03	693	22	4	PF00096
Domain	ZINC_FINGER_C2H2_2	RLF ZNF277 ZFX ZFY	1.18e-02	775	22	4	PS50157
Domain	ZINC_FINGER_C2H2_1	RLF ZNF277 ZFX ZFY	1.20e-02	777	22	4	PS00028
Domain	Znf_FYVE_PHD	TRIM66 NSD3	1.28e-02	147	22	2	IPR011011
Domain	Znf_C2H2-like	RLF ZNF277 ZFX ZFY	1.30e-02	796	22	4	IPR015880
Domain	Znf_C2H2	RLF ZNF277 ZFX ZFY	1.35e-02	805	22	4	IPR007087
Domain	ZnF_C2H2	RLF ZNF277 ZFX ZFY	1.36e-02	808	22	4	SM00355
Domain	-	TOPORS TRIM66 NSD3	1.51e-02	449	22	3	3.30.40.10
Domain	Znf_RING/FYVE/PHD	TOPORS TRIM66 NSD3	1.60e-02	459	22	3	IPR013083
Pubmed	Praja1, a novel gene encoding a RING-H2 motif in mouse development.	FLNA ZFX ZFY	2.12e-08	9	23	3	9393880
Pubmed	Comparison of human ZFY and ZFX transcripts.	ZFX ZFY	4.18e-07	2	23	2	2308929
Pubmed	Mapping the human ZFX locus to Xp21.3 by in situ hybridization.	ZFX ZFY	4.18e-07	2	23	2	2497060
Pubmed	RNAi as a tool to control the sex ratio of mouse offspring by interrupting Zfx/Zfy genes in the testis.	ZFX ZFY	4.18e-07	2	23	2	28251288
Pubmed	Differential rates of evolution for the ZFY-related zinc finger genes, Zfy, Zfx, and Zfa in the mouse genus Mus.	ZFX ZFY	4.18e-07	2	23	2	12716983
Pubmed	Intron/exon structure confirms that mouse Zfy1 and Zfy2 are members of the ZFY gene family.	ZFX ZFY	4.18e-07	2	23	2	9126493
Pubmed	Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY.	ZFX ZFY	4.18e-07	2	23	2	2041734
Pubmed	Gene expression, X-inactivation, and methylation during spermatogenesis: the case of Zfa, Zfx, and Zfy in mice.	ZFX ZFY	4.18e-07	2	23	2	8318216
Pubmed	Mouse Zfx protein is similar to Zfy-2: each contains an acidic activating domain and 13 zinc fingers.	ZFX ZFY	4.18e-07	2	23	2	2105457
Pubmed	Transcription factor Zfx controls BCR-induced proliferation and survival of B lymphocytes.	ZFX ZFY	4.18e-07	2	23	2	19329779
Pubmed	Circ_0000520 contributes to triple-negative breast cancer progression through mediating the miR-1296/ZFX axis.	ZFX ZFY	4.18e-07	2	23	2	34324278
Pubmed	Zfx mutation results in small animal size and reduced germ cell number in male and female mice.	ZFX ZFY	4.18e-07	2	23	2	9187153
Pubmed	Chromosomal localization of ZFX--a human gene that escapes X inactivation--and its murine homologs.	ZFX ZFY	4.18e-07	2	23	2	1970799
Pubmed	Evolution of the Zfx and Zfy genes: rates and interdependence between the genes.	ZFX ZFY	4.18e-07	2	23	2	8487630
Pubmed	[Expression of Zfx in mouse testicular spermatogenic cells].	ZFX ZFY	4.18e-07	2	23	2	38602753
Pubmed	Zfa is an expressed retroposon derived from an alternative transcript of the Zfx gene.	ZFX ZFY	4.18e-07	2	23	2	1691708
Pubmed	Regional assignments of the zinc finger Y-linked gene (ZFY) and related sequences on human and mouse chromosomes.	ZFX ZFY	4.18e-07	2	23	2	2265557
Pubmed	The structure of the Zfx gene on the mouse X chromosome.	ZFX ZFY	4.18e-07	2	23	2	8188262
Pubmed	TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.	CHD6 ZFX ZFY NSD3	7.72e-07	109	23	4	33554859
Pubmed	YAC clone contigs surrounding the Zfx and Pola loci on the mouse X chromosome.	ZFX ZFY	1.25e-06	3	23	2	8406471
Pubmed	Zfy gene expression patterns are not compatible with a primary role in mouse sex determination.	ZFX ZFY	1.25e-06	3	23	2	2480529
Pubmed	X chromosome genes and premature ovarian failure.	ZFX ZFY	1.25e-06	3	23	2	11299520
Pubmed	Genetic dissection of mammalian fertility pathways.	ZFX ZFY	1.25e-06	3	23	2	12479614
Pubmed	Isolation of monochromosomal hybrids for mouse chromosomes 3, 6, 10, 12, 14, and 18.	ZFX ZFY	1.25e-06	3	23	2	9060403
Pubmed	Blockade of ZFX Alleviates Hypoxia-Induced Pulmonary Vascular Remodeling by Regulating the YAP Signaling.	ZFX ZFY	1.25e-06	3	23	2	38310188
Pubmed	Characterization of the ZFX family of transcription factors that bind downstream of the start site of CpG island promoters.	ZFX ZFY	1.25e-06	3	23	2	32406922
Pubmed	ZFX controls propagation and prevents differentiation of acute T-lymphoblastic and myeloid leukemia.	ZFX ZFY	2.51e-06	4	23	2	24485662
Pubmed	Zfx controls the self-renewal of embryonic and hematopoietic stem cells.	ZFX ZFY	2.51e-06	4	23	2	17448993
Pubmed	Chromosome mapping and expression of a putative testis-determining gene in mouse.	ZFX ZFY	4.18e-06	5	23	2	2563174
Pubmed	The human gene ZFP161 on 18p11.21-pter encodes a putative c-myc repressor and is homologous to murine Zfp161 (Chr 17) and Zfp161-rs1 (X Chr).	ZFX ZFY	4.18e-06	5	23	2	9244432
Pubmed	MSG1 (melanocyte-specific gene 1): mapping to chromosome Xq13.1, genomic organization, and promoter analysis.	ZFX ZFY	4.18e-06	5	23	2	9721210
Pubmed	Maintenance of X inactivation of the Rps4, Zfx, and Ube1 genes in a mouse in vitro system.	ZFX ZFY	4.18e-06	5	23	2	7681608
Pubmed	Zfx facilitates tumorigenesis caused by activation of the Hedgehog pathway.	ZFX ZFY	4.18e-06	5	23	2	25164012
Pubmed	Sequence and expression of murine cDNAs encoding Xlr3a and Xlr3b, defining a new X-linked lymphocyte-regulated Xlr gene subfamily.	ZFX ZFY	6.26e-06	6	23	2	7821804
Pubmed	An evaluation of the inactive mouse X chromosome in somatic cell hybrids.	ZFX ZFY	8.77e-06	7	23	2	8460399
Pubmed	Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma chain expression.	ZFX ZFY	8.77e-06	7	23	2	8378320
Pubmed	Embryonic growth and the evolution of the mammalian Y chromosome. II. Suppression of selfish Y-linked growth factors may explain escape from X-inactivation and rapid evolution of Sry.	ZFX ZFY	8.77e-06	7	23	2	7928394
Pubmed	Genetic mapping in the mouse of Kif4, a gene encoding a kinesin-like motor protein.	ZFX ZFY	8.77e-06	7	23	2	9196009
Pubmed	The Dazh gene is expressed in male and female embryonic gonads before germ cell sex differentiation.	ZFX ZFY	8.77e-06	7	23	2	9588208
Pubmed	Genetic mapping in the region of the mouse X-inactivation center.	ZFX ZFY	1.17e-05	8	23	2	1974879
Pubmed	Conservation of position and exclusive expression of mouse Xist from the inactive X chromosome.	ZFX ZFY	1.17e-05	8	23	2	2034279
Pubmed	High-density molecular map of the central span of the mouse X chromosome.	ZFX ZFY	1.17e-05	8	23	2	1675191
Pubmed	exma: an X-linked insertional mutation that disrupts forebrain and eye development.	ZFX ZFY	1.50e-05	9	23	2	11956759
Pubmed	Structure, chromosomal location, and expression pattern of three mouse genes homologous to the human MAGE genes.	ZFX ZFY	1.50e-05	9	23	2	7590750
Pubmed	Cloning and characterization of a new human Xq13 gene, encoding a putative helicase.	ZFX ZFY	1.50e-05	9	23	2	7874112
Pubmed	The mouse genes encoding the third pair of beta-type proteasome subunits regulated reciprocally by IFN-gamma: structural comparison, chromosomal localization, and analysis of the promoter.	ZFX ZFY	1.50e-05	9	23	2	9300697
Pubmed	Genetic and molecular evidence of an X-chromosome deletion spanning the tabby (Ta) and testicular feminization (Tfm) loci in the mouse.	ZFX ZFY	1.88e-05	10	23	2	2055107
Pubmed	Mapping of the phosphorylase kinase alpha subunit gene on the mouse X chromosome.	ZFX ZFY	1.88e-05	10	23	2	1973380
Pubmed	Characterization of a murine gene expressed from the inactive X chromosome.	ZFX ZFY	2.29e-05	11	23	2	2034278
Pubmed	Zinc finger protein genes in the mouse genome.	ZFX ZFY	2.75e-05	12	23	2	1797234
Pubmed	The construction of human somatic cell hybrids containing portions of the mouse X chromosome and their use to generate DNA probes via interspersed repetitive sequence polymerase chain reaction.	ZFX ZFY	2.75e-05	12	23	2	1916827
Pubmed	Rps4 maps near the inactivation center on the mouse X chromosome.	ZFX ZFY	3.25e-05	13	23	2	1740345
Pubmed	The murine interleukin-2 receptor gamma chain gene: organization, chromosomal localization and expression in the adult thymus.	ZFX ZFY	3.25e-05	13	23	2	7805729
Pubmed	Localization of murine X and autosomal sequences homologous to the human Y located testis-determining region.	ZFX ZFY	3.25e-05	13	23	2	2721933
Pubmed	XIST and the mapping of the X chromosome inactivation centre.	ZFX ZFY	3.25e-05	13	23	2	1772416
Pubmed	Mapping of a liver phosphorylase kinase alpha-subunit gene on the mouse X chromosome.	ZFX ZFY	3.79e-05	14	23	2	8432533
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	RLF CHD6 NSD3 DDX10 LYAR	4.16e-05	608	23	5	36089195
Pubmed	Molecular phylogenetics and the origins of placental mammals.	ZFX ZFY	4.37e-05	15	23	2	11214319
Pubmed	Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse.	ZFX ZFY	4.37e-05	15	23	2	11353388
Pubmed	Evolutionary strata on the mouse X chromosome correspond to strata on the human X chromosome.	ZFX ZFY	4.37e-05	15	23	2	14762062
Pubmed	Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation.	CMTM2 CCDC190 NUAK2 DDX10	4.50e-05	305	23	4	21244100
Pubmed	STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production.	FLNA POP1 DDX10 LYAR	5.17e-05	316	23	4	31665637
Pubmed	Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation.	ZFX ZFY	5.66e-05	17	23	2	19571810
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	ERC2 FLNA CHD6 POP1	8.83e-05	363	23	4	14691545
Pubmed	Positioning of five genes (CASK, ARX, SAT, IMAGE cDNAs 248928 and 253949) from the human X chromosome short arm with respect to evolutionary breakpoints on the mouse X chromosome.	ZFX ZFY	1.35e-04	26	23	2	10920247
Pubmed	Gene knockouts that cause female infertility: search for novel contraceptive targets.	ZFX ZFY	1.56e-04	28	23	2	15970507
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	RLF FLNA POP1 DDX10 PSME4 LYAR	1.96e-04	1353	23	6	29467282
Pubmed	The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.	FLNA POP1 DDX10 LYAR	2.64e-04	483	23	4	36912080
Pubmed	Relationships between hematopoiesis and hepatogenesis in the midtrimester fetal liver characterized by dynamic transcriptomic and proteomic profiles.	ZFX ZFY	2.75e-04	37	23	2	19865483
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	ZNF277 CHD6 NSD3 POP1 DDX10 LYAR	3.38e-04	1497	23	6	31527615
Pubmed	Directed proteomic analysis of the human nucleolus.	POP1 DDX10 LYAR	3.42e-04	208	23	3	11790298
Pubmed	Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.	POP1 PSME4	3.54e-04	42	23	2	7584044
Pubmed	In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.	RLF ERC2 FLNA POP1 LYAR	3.72e-04	971	23	5	33306668
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	ZFX ZFY NSD3 DDX10	3.83e-04	533	23	4	30554943
Pubmed	Fbxl17 is rearranged in breast cancer and loss of its activity leads to increased global O-GlcNAcylation.	RLF PSME4	4.25e-04	46	23	2	31560077
Pubmed	circPDE4B prevents articular cartilage degeneration and promotes repair by acting as a scaffold for RIC8A and MID1.	FLNA LYAR	5.44e-04	52	23	2	34039624
Pubmed	Identification of proteins associated with ligand-activated estrogen receptor α in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS.	FLNA POP1 LYAR	5.51e-04	245	23	3	21182205
Pubmed	Functional proteomics mapping of a human signaling pathway.	RLF TOPORS FLNA CHD6	5.65e-04	591	23	4	15231748
Pubmed	Identification of novel SHPS-1-associated proteins and their roles in regulation of insulin-like growth factor-dependent responses in vascular smooth muscle cells.	FLNA DDX10	6.30e-04	56	23	2	19299420
Cytoband	4p16.3	POLN LYAR	8.36e-04	85	23	2	4p16.3
Cytoband	Ensembl 112 genes in cytogenetic band chr4p16	POLN LYAR	5.51e-03	222	23	2	chr4p16
GeneFamily	PHD finger proteins	TRIM66 NSD3	2.14e-03	90	14	2	88
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	RLF ZFX ZFY	1.64e-02	718	14	3	28
Coexpression	XIE_TRASTUZUMAB_CARDIOTOXICITY_MMU_MIR_193A_3P_GENES	ZFX ZFY	5.71e-05	13	23	2	MM17497
Coexpression	NAKAYA_PBMC_FLUMIST_AGE_18_50YO_7DY_DN	RLF TOPORS CMTM2 ZFX ZFY NUAK2	6.91e-05	844	23	6	M41129
Coexpression	ZHENG_CORD_BLOOD_C2_PUTATIVE_BASOPHIL_EOSINOPHIL_MAST_CELL_PROGENITOR	FLNA PSME4 LYAR	8.00e-05	96	23	3	M39211
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TRIM66 FLNA NUAK2 LYAR	2.90e-06	196	23	4	c57a95f8b4d8d6334f269d3c16246684f4222a3e
Disease	daytime rest measurement	ERC2 CCDC190 GKAP1	1.32e-03	295	22	3	EFO_0007828
Disease	diet measurement	TRIM66 ERC2 CHD6 NUAK2	6.96e-03	1049	22	4	EFO_0008111
Disease	Malignant neoplasm of breast	ZNF277 FLNA POP1 DDX10	7.56e-03	1074	22	4	C0006142
Disease	age at menarche	TRIM66 ERC2 CCDC190	9.40e-03	594	22	3	EFO_0004703

Protein segments in the cluster

Peptide	Gene	Start	Entry
KQAQHRIKEMKQMHP	ANKRD18B	521	A2A2Z9
MNKKDKRKNHQGKDR	GKAP1	161	Q5VSY0
KKGHKRKHFLMENIN	POLN	131	Q7Z5Q5
MRGKDKKQQPRKAHR	IHO1	436	Q8IYA8
PLREMQKHLGKKRQH	LENG1	156	Q96BZ8
QGRQKHRAPQAKKMR	CCDC190	91	Q86UF4
RHMKDQNKKVANLKH	ERC2	756	O15083
ERKHAKKMRNQPTNV	POP1	6	Q99575
QKIKRFRNKQAQMKH	CHD6	346	Q8TD26
QKKMHRKHNQRPTFR	FLNA	86	P21333
HQENSRNQKPKKRKK	LYAR	211	Q9NX58
KHSHRQNKKKQLRKQ	DDX10	26	Q13206
PKPLMKKQAVKRHHH	NUAK2	31	Q9H093
NHFRGKKAKKHMLVP	CMTM2	201	Q8TAZ6
KNARGMQKHLRKVHP	RLF	966	Q13129
VKKSMENRLHGKKQH	PSME4	921	Q14997
QLKKKEMHSKPHRQL	ZC3H12B	66	Q5HYM0
KQKRRKIKTEPKQMH	NSD3	1306	Q9BZ95
KNTLKDHMRKKQHRK	ZNF277	236	Q9NRM2
DHMRKKQHRKINPKN	ZNF277	241	Q9NRM2
DQKNHRKHHGKKRMK	TOPORS	611	Q9NS56
KRHMKNHPEHLAKKK	ZFX	441	P17010
KHQHRKVENQIKMAK	TRIM66	141	O15016
RKGFRQQNELKKHMK	ZFY	721	P08048