Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionacetylcholine receptor regulator activity

SPDYE5 SPDYE2B SPDYE4 SPDYE6 SPDYE2

4.51e-0927475GO:0030548
GeneOntologyMolecularFunctionneurotransmitter receptor regulator activity

SPDYE5 SPDYE2B SPDYE4 SPDYE6 SPDYE2

5.48e-0928475GO:0099602
GeneOntologyMolecularFunctionalcohol-forming very long-chain fatty acyl-CoA reductase activity

FAR1 FAR2

5.42e-062472GO:0080019
GeneOntologyMolecularFunctionalcohol-forming long-chain fatty acyl-CoA reductase activity

FAR1 FAR2

5.42e-062472GO:0102965
GeneOntologyMolecularFunctionprotein kinase binding

SPDYE21 IL12RB2 PTPN14 SPDYE5 SPDYE2B SPDYE4 SPDYE6 SPDYE2

8.93e-04873478GO:0019901
GeneOntologyMolecularFunctionkinase binding

SPDYE21 IL12RB2 PTPN14 SPDYE5 SPDYE2B SPDYE4 SPDYE6 SPDYE2

1.74e-03969478GO:0019900
GeneOntologyMolecularFunctioncalmodulin binding

ASPM SLC8A3 MYO15A IQCB1

2.07e-03230474GO:0005516
GeneOntologyMolecularFunctionATP-dependent chromatin remodeler activity

CHD9 ERCC6

3.43e-0337472GO:0140658
GeneOntologyBiologicalProcesspositive regulation of cyclin-dependent protein serine/threonine kinase activity

SPDYE5 SPDYE2B SPDYE4 SPDYE6 SPDYE2

2.53e-0925475GO:0045737
GeneOntologyBiologicalProcesspositive regulation of cyclin-dependent protein kinase activity

SPDYE5 SPDYE2B SPDYE4 SPDYE6 SPDYE2

4.66e-0928475GO:1904031
GeneOntologyBiologicalProcessregulation of cyclin-dependent protein serine/threonine kinase activity

SPDYE5 SPDYE2B SPDYE4 SPDYE6 SPDYE2

2.58e-0696475GO:0000079
GeneOntologyBiologicalProcessregulation of cyclin-dependent protein kinase activity

SPDYE5 SPDYE2B SPDYE4 SPDYE6 SPDYE2

3.16e-06100475GO:1904029
GeneOntologyBiologicalProcesspositive regulation of protein serine/threonine kinase activity

SPDYE5 PIK3R6 SPDYE2B SPDYE4 SPDYE6 SPDYE2

4.85e-06193476GO:0071902
GeneOntologyBiologicalProcessregulation of protein serine/threonine kinase activity

SLC8A3 SPDYE5 PIK3R6 SPDYE2B SPDYE4 SPDYE6 SPDYE2

1.55e-05358477GO:0071900
GeneOntologyBiologicalProcesswax biosynthetic process

FAR1 FAR2

3.04e-054472GO:0010025
GeneOntologyBiologicalProcesswax metabolic process

FAR1 FAR2

3.04e-054472GO:0010166
GeneOntologyBiologicalProcesspositive regulation of protein kinase activity

SPDYE5 PIK3R6 SPDYE2B SPDYE4 SPDYE6 SPDYE2

1.37e-04350476GO:0045860
GeneOntologyBiologicalProcesspositive regulation of kinase activity

SPDYE5 PIK3R6 SPDYE2B SPDYE4 SPDYE6 SPDYE2

3.00e-04405476GO:0033674
GeneOntologyBiologicalProcessregulation of protein kinase activity

SLC8A3 SPDYE5 PIK3R6 SPDYE2B SPDYE4 SPDYE6 SPDYE2

4.34e-04611477GO:0045859
DomainSpeedy

SPDYE21 SPDYE5 SPDYE2B SPDYE4 SPDYE6 SPDYE2

5.49e-1411446IPR020984
DomainSpy1

SPDYE21 SPDYE5 SPDYE2B SPDYE4 SPDYE6 SPDYE2

5.49e-1411446PF11357
DomainFAR

FAR1 FAR2

5.42e-062442IPR026055
DomainFAR_C

FAR1 FAR2

5.42e-062442IPR033640
DomainMale_sterile_NAD-bd

FAR1 FAR2

5.42e-062442IPR013120
DomainNAD_binding_4

FAR1 FAR2

5.42e-062442PF07993
DomainSterile

FAR1 FAR2

5.42e-062442PF03015
DomainTypeI_recpt_CBD

IL12RB2 IL3RA

2.94e-0411442IPR015321
DomainIL6Ra-bind

IL12RB2 IL3RA

2.94e-0411442PF09240
DomainIQ

ASPM MYO15A IQCB1

6.23e-0471443PF00612
DomainIQ

ASPM MYO15A IQCB1

9.16e-0481443SM00015
DomainIQ_motif_EF-hand-BS

ASPM MYO15A IQCB1

1.24e-0390443IPR000048
DomainIQ

ASPM MYO15A IQCB1

1.37e-0393443PS50096
DomainKRAB

ZNF264 ZNF215 ZNF91 ZNF45 ZNF540

1.48e-03358445PS50805
DomainKRAB

ZNF264 ZNF215 ZNF91 ZNF45 ZNF540

1.48e-03358445PF01352
DomainKRAB

ZNF264 ZNF215 ZNF91 ZNF45 ZNF540

1.69e-03369445SM00349
DomainKRAB

ZNF264 ZNF215 ZNF91 ZNF45 ZNF540

1.71e-03370445IPR001909
DomainSNF2_N

CHD9 ERCC6

2.57e-0332442PF00176
DomainSNF2_N

CHD9 ERCC6

2.57e-0332442IPR000330
Domain-

ALAS1 GLDC

3.80e-03394423.40.640.10
DomainPyrdxlP-dep_Trfase

ALAS1 GLDC

4.20e-0341442IPR015424
DomainPyrdxlP-dep_Trfase_major_sub1

ALAS1 GLDC

4.20e-0341442IPR015421
Domain-

ZNF264 ZNF215 HIVEP1 ZNF91 ZNF45 ZNF540

4.91e-036794463.30.160.60
DomainFERM_M

PTPN14 MYO15A

5.26e-0346442PF00373
Domainzf-C2H2

ZNF264 ZNF215 HIVEP1 ZNF91 ZNF45 ZNF540

5.42e-03693446PF00096
DomainZnf_C2H2/integrase_DNA-bd

ZNF264 ZNF215 HIVEP1 ZNF91 ZNF45 ZNF540

5.46e-03694446IPR013087
DomainFERM_central

PTPN14 MYO15A

5.95e-0349442IPR019748
DomainFERM_domain

PTPN14 MYO15A

5.95e-0349442IPR000299
DomainFERM_1

PTPN14 MYO15A

6.18e-0350442PS00660
DomainFERM_2

PTPN14 MYO15A

6.18e-0350442PS00661
DomainBand_41_domain

PTPN14 MYO15A

6.18e-0350442IPR019749
DomainB41

PTPN14 MYO15A

6.18e-0350442SM00295
DomainFERM_3

PTPN14 MYO15A

6.18e-0350442PS50057
DomainPTPc_motif

PTPN14 TNS1

8.52e-0359442SM00404
DomainTyr_Pase_cat

PTPN14 TNS1

8.52e-0359442IPR003595
DomainZINC_FINGER_C2H2_2

ZNF264 ZNF215 HIVEP1 ZNF91 ZNF45 ZNF540

9.21e-03775446PS50157
DomainZINC_FINGER_C2H2_1

ZNF264 ZNF215 HIVEP1 ZNF91 ZNF45 ZNF540

9.32e-03777446PS00028
DomainZnf_C2H2-like

ZNF264 ZNF215 HIVEP1 ZNF91 ZNF45 ZNF540

1.04e-02796446IPR015880
DomainZnf_C2H2

ZNF264 ZNF215 HIVEP1 ZNF91 ZNF45 ZNF540

1.10e-02805446IPR007087
PathwayREACTOME_WAX_AND_PLASMALOGEN_BIOSYNTHESIS

FAR1 FAR2

7.45e-056322MM15480
PathwayREACTOME_WAX_AND_PLASMALOGEN_BIOSYNTHESIS

FAR1 FAR2

1.04e-047322M27730
PathwayREACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA

NFYA NCOR1 CHD9 ALAS1

1.40e-04118324M27316
PathwayREACTOME_METABOLISM_OF_LIPIDS

NFYA NCOR1 CHD9 ALAS1 MCAT FAR1 FAR2 PIK3R6

2.22e-04757328M27451
PathwayREACTOME_TRANSCRIPTIONAL_ACTIVATION_OF_MITOCHONDRIAL_BIOGENESIS

NCOR1 CHD9 ALAS1

2.57e-0455323M27145
PathwayREACTOME_ORGANELLE_BIOGENESIS_AND_MAINTENANCE

CC2D2A NCOR1 CHD9 ALAS1 IQCB1

5.07e-04297325M27050
PathwayWP_ETHER_LIPID_BIOSYNTHESIS

FAR1 FAR2

9.25e-0420322M46451
Pubmed

Murine fertility and spermatogenesis are independent of the testis-specific Spdye4a gene.

SPDYE5 SPDYE2B SPDYE4 SPDYE6 SPDYE2

5.07e-13948536272447
Pubmed

Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.

SPDYE5 SPDYE2B SPDYE4 SPDYE6 SPDYE2

5.16e-121348515611625
Pubmed

Characterization of a new family of cyclin-dependent kinase activators.

SPDYE5 SPDYE2B SPDYE4 SPDYE6 SPDYE2

2.47e-111748515574121
Pubmed

Mammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributions.

FAR1 FAR2

1.87e-06248215220348
Pubmed

Topogenesis and homeostasis of fatty acyl-CoA reductase 1.

FAR1 FAR2

1.87e-06248224108123
Pubmed

Evolution of the Cdk-activator Speedy/RINGO in vertebrates.

SPDYE6 SPDYE2

5.59e-06348222763696
Pubmed

Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family.

FAR1 FAR2

5.59e-06348215220349
Pubmed

Three novel spermatogenesis-specific zinc finger genes.

ZSCAN12 ZNF45

1.12e-05448212860387
Pubmed

The transcription factor NF-YA is crucial for neural progenitor maintenance during brain development.

NFYA ASPM

1.02e-041148238199563
Pubmed

CRISPR/Cas9-mediated Genomic Editing of Cluap1/IFT38 Reveals a New Role in Actin Arrangement.

ASPM FAR1 NISCH SEC62

2.15e-0421348429615496
Pubmed

Mutation analysis of 18 nephronophthisis associated ciliopathy disease genes using a DNA pooling and next generation sequencing strategy.

CC2D2A IQCB1

2.81e-041848221068128
Pubmed

Biochemistry of mammalian peroxisomes revisited.

FAR1 FAR2

3.49e-042048216756494
Pubmed

The DNA sequence of human chromosome 7.

SPDYE21 SPDYE5 ZNHIT1 SPDYE2B SPDYE6

3.50e-0444148512853948
Pubmed

Discovery and validation of genes driving drug-intake and related behavioral traits in mice.

IL12RB2 FAR2

9.58e-043348238164795
Pubmed

Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain.

FAR1 SEC62 EIF5

1.03e-0314348332560809
Pubmed

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

CC2D2A FAR1 MYO15A NISCH IQCB1

1.06e-0356448521565611
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

ASPM NCOR1 PTPN14 HIVEP1 IQCB1

1.28e-0358848538580884
Cytoband7q22.1

ZNHIT1 SPDYE2B SPDYE6 SPDYE2

6.23e-061134847q22.1
CytobandEnsembl 112 genes in cytogenetic band chr7q22

ZNHIT1 SPDYE2B SPDYE6 SPDYE2

8.31e-05219484chr7q22
Cytoband3p21.1

ALAS1 NISCH

8.97e-04424823p21.1
GeneFamilySpeedy/RINGO cell cycle regulator family

SPDYE5 SPDYE2B SPDYE4 SPDYE6 SPDYE2

3.95e-1212275756
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF264 ZNF215 HIVEP1 ZSCAN12 ZNF91 ZNF45 ZNF540

6.70e-0571827728
GeneFamilyCD molecules|I-set domain containing|Immunoglobulin like domain containing|Interleukin receptors|TIR domain containing

IL12RB2 IL3RA

1.78e-0342272602
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

PTPN14 MYO15A

2.52e-03502721293
GeneFamilyShort chain dehydrogenase/reductase superfamily

FAR1 FAR2

5.72e-0376272743
ToppCellPBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

IL12RB2 ZSCAN12 ZNF540 IQCB1

2.40e-0515648484f01419d8c116714e8c8c857c4d153a755b7867
ToppCellPBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_4|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IL12RB2 ZSCAN12 ZNF540 IQCB1

2.40e-051564842285be9746d0d0f62a488b9c64fa67a834758dd7
ToppCellBAL-Control-cDC_6|Control / Compartment, Disease Groups and Clusters

ASPM ZNF91 PIK3R6 EIF5

3.21e-0516848465ec473cff748b334c0a66e33bc34a8465fe7631
ToppCell3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2-Transitional_Club-AT2_L.0.4.1.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DUOX1 TYW3 HIVEP1 ZSCAN12

3.76e-05175484dbd9dac129fb6ae5f55e7b96d04b37585458dc4a
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_B-plasmablast-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ASPM ZNF215 SPDYE2B GLDC

3.94e-05177484d2c1f46913ac00bbc0bb9320d5652edc01b34179
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_B-plasmablast|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ASPM ZNF215 SPDYE2B GLDC

3.94e-0517748465e090aad0ffb737ce034e25bd5b12a0b1dd9684
ToppCell3'_v3-bone_marrow-Mast|bone_marrow / Manually curated celltypes from each tissue

ALAS1 PIK3R6 IL3RA CRISPLD1

4.20e-05180484b37ee81b792213d6595b4ec65d04bc35d83321c7
ToppCellCOVID-19-lung-Plasma_cells_PRDM1/BLIMP_hi|lung / Disease (COVID-19 only), tissue and cell type

ASPM ZNF215 GLDC IQCB1

4.77e-0518648466676d9395172de5707e204826a1c9f73b448cca
ToppCellSepsis-ICU-NoSEP-Lymphocyte-B-Plasmablast|ICU-NoSEP / Disease, condition lineage and cell class

ASPM IL12RB2 ZNF215 GLDC

5.97e-051974848f35f9741086a38f0e594dce0547b575946f52bb
ToppCellTransverse-(7)_Mast_cell-(70)_Mast|Transverse / shred on region, Cell_type, and subtype

ALAS1 SLC8A3 PIK3R6 TNS1

6.33e-05200484aa17354c83b0967707d995e4b74e042ac211f814
ToppCellTransverse-Mast_cell-Mast|Transverse / Region, Cell class and subclass

ALAS1 SLC8A3 PIK3R6 TNS1

6.33e-052004840af942a33cc50da65129204976e24203320e206d
ToppCellTransverse-Mast_cell|Transverse / Region, Cell class and subclass

ALAS1 SLC8A3 PIK3R6 TNS1

6.33e-052004845e3f5349ffbcabdca3d911fbc99a46aaa56c47c4
ToppCellTransverse-(7)_Mast_cell|Transverse / shred on region, Cell_type, and subtype

ALAS1 SLC8A3 PIK3R6 TNS1

6.33e-05200484d90d1d3015a9258298bd6b4ba07971aa1af8b82b
Diseaseteratocarcinoma-derived growth factor 1 measurement

SLC8A3 TNS1

2.34e-0416422EFO_0008297
Diseasewellbeing measurement

ALAS1 TYW3 HIVEP1 ZSCAN12 MFHAS1 SEC62

4.16e-04692426EFO_0007869
DiseaseMalignant neoplasm of breast

NCOR1 SLC8A3 PTPN14 ERCC6 TNS1 NISCH EIF5

7.34e-041074427C0006142
Diseasebone quantitative ultrasound measurement

FAR2 MFHAS1

1.42e-0339422EFO_0004514
Diseaseneuroticism measurement

ALAS1 TYW3 PTPN14 HIVEP1 ZSCAN12 MFHAS1

1.71e-03909426EFO_0007660
Diseasedepressive symptom measurement

ALAS1 TYW3 HIVEP1 ZSCAN12

3.11e-03426424EFO_0007006
Diseasediverticular disease

TNS1 NISCH UNC50

4.61e-03236423EFO_0009959
Diseasemetabolite measurement, diet measurement

NCOR1 GLDC

4.62e-0371422EFO_0004725, EFO_0008111
Diseasesystemic lupus erythematosus

IL12RB2 CHD9 MFHAS1 GLDC IQCB1

5.34e-03799425MONDO_0007915

Protein segments in the cluster

PeptideGeneStartEntry
QYQQHFSRRVKRREK

C16orf89

301

Q6UX73
PKRQSNHRQEVYFRF

APOBEC3D

61

Q96AK3
KIYHRQIFKQFLTNR

ERCC6

971

Q03468
FRARLQEKRFIQKYH

ASPM

3151

Q8IZT6
NINYHFKRRAKAFTQ

ARMCX4

2231

Q5H9R4
VQQFKRFIENYRRHI

DUOX1

1031

Q9NRD9
KRLRNIHYLFNTALF

FAR2

461

Q96K12
ARKHLNKLRNIRYGF

FAR1

456

Q8WVX9
KNLRRRKAHFQYLLN

MFHAS1

601

Q9Y4C4
KNDHTYRVFKTVNRR

ALAS1

211

P13196
KSRIVFQAKNERNYH

MYO15A

1396

Q9UKN7
NKLILYKFDRRINFH

IL12RB2

66

Q99665
FRDCNKIAFYRRQKQ

GANC

21

Q8TET4
RFLQKNSSKFHFRRT

MCAT

246

Q8IVS2
IKRFKLRQAQRAHFF

CHD9

746

Q3L8U1
LRFCHNNKKAQRYLL

EIF5

301

P55010
HFNRKFRYELQIQKR

IL3RA

231

P26951
DQYLARHQRNKAKFL

CC2D2A

436

Q9P2K1
TRQGRKHYFIKSNRN

CRISPLD1

356

Q9H336
YRERKNFHQQRQSLI

IQCB1

401

Q15051
RKYIAYRLIQHARNN

FAM186A

2156

A6NE01
RQRRVQSYEFLQKKH

POLR3E

186

Q9NVU0
YVNAKQYHRILKRRQ

NFYA

266

P23511
KSFFRQLNLYGFRKR

HSFX1

151

Q9UBD0
LFFKRRNHARKQREQ

NCOR1

291

O75376
AQAYHRLRKRETQKF

PIK3R6

431

Q5UE93
ISRLFATRHKFYKQN

PTPN14

291

Q15678
KQNIFHFLYRKNRSR

SPDYE2B

266

A6NHP3
QRVYRNFHYRKQTKD

UNC50

61

Q53HI1
RKAFRQYSHLYQHQK

ZNF540

641

Q8NDQ6
YCNRLLKKQFFHRAL

SEC62

81

Q99442
KQNIFHFLYGKTRSR

SPDYE21

266

A0A494C086
KQNIFHFLYRKNRSR

SPDYE2

266

Q495Y8
KNYSQRPLFHKLRYQ

SPDYE4

186

A6NLX3
KQNIFHFLYGKNRSR

SPDYE5

266

A6NIY4
KQNIFHFLYRKNRSR

SPDYE6

266

P0CI01
NQRKLFFRRHYPLNT

TNS1

1651

Q9HBL0
KFHFLRVYNQLRASL

NISCH

991

Q9Y2I1
KAFNRKSYLTQHQRI

ZNF264

266

O43296
KVFYKFLNSNRHTIR

ZNF91

161

Q05481
ASRQKFRHFQYLKVS

ZNF215

46

Q9UL58
TRGDHFKLRFRKNFQ

ZNHIT1

71

O43257
KNNTHSREVFRQYFR

ZSCAN12

36

O43309
KRFRQRSYLQAHQRV

ZNF45

591

Q02386
NRYRKLENFENHKKF

HIVEP1

966

P15822
NKKRIERFYNCLQHA

TYW3

181

Q6IPR3
ALQLCYRHNKRRKFL

GLDC

206

P23378
HQQKSRAFYRIQATR

SLC8A3

346

P57103