Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	mitogen-activated protein kinase kinase kinase binding	DAZAP2 TCF3 MARVELD3	9.48e-06	26	32	3	GO:0031435
GeneOntologyMolecularFunction	structural constituent of skin epidermis	KRT3 KRT74 KRT73	4.42e-05	43	32	3	GO:0030280
GeneOntologyMolecularFunction	structural molecule activity	OBSCN LAMA2 KRT3 KRT12 KRT13 COL17A1 KRT74 KRT73	6.16e-05	891	32	8	GO:0005198
GeneOntologyMolecularFunction	RNA stem-loop binding	DAZAP1 DHX9	5.13e-04	21	32	2	GO:0035613
GeneOntologyMolecularFunction	protein transmembrane transporter activity	TIMM23 TIMM22	9.16e-04	28	32	2	GO:0008320
GeneOntologyMolecularFunction	macromolecule transmembrane transporter activity	TIMM23 TIMM22	1.35e-03	34	32	2	GO:0022884
GeneOntologyBiologicalProcess	intermediate filament organization	KRT3 KRT12 KRT13 KRT74 KRT73	1.22e-07	75	33	5	GO:0045109
GeneOntologyBiologicalProcess	intermediate filament cytoskeleton organization	KRT3 KRT12 KRT13 KRT74 KRT73	4.91e-07	99	33	5	GO:0045104
GeneOntologyBiologicalProcess	intermediate filament-based process	KRT3 KRT12 KRT13 KRT74 KRT73	5.16e-07	100	33	5	GO:0045103
GeneOntologyCellularComponent	keratin filament	KRT3 KRT13 KRT74 KRT73	1.61e-05	97	33	4	GO:0045095
GeneOntologyCellularComponent	intermediate filament	KRT3 KRT12 KRT13 KRT74 KRT73	2.68e-05	227	33	5	GO:0005882
GeneOntologyCellularComponent	intermediate filament cytoskeleton	KRT3 KRT12 KRT13 KRT74 KRT73	5.40e-05	263	33	5	GO:0045111
HumanPheno	Epiphora	KRT3 KRT12 COL17A1	3.67e-05	27	13	3	HP:0009926
Domain	Intermediate_filament_CS	KRT3 KRT12 KRT13 KRT74 KRT73	5.90e-08	63	31	5	IPR018039
Domain	Filament	KRT3 KRT12 KRT13 KRT74 KRT73	1.08e-07	71	31	5	SM01391
Domain	IF	KRT3 KRT12 KRT13 KRT74 KRT73	1.16e-07	72	31	5	PS00226
Domain	Filament	KRT3 KRT12 KRT13 KRT74 KRT73	1.25e-07	73	31	5	PF00038
Domain	IF	KRT3 KRT12 KRT13 KRT74 KRT73	1.53e-07	76	31	5	IPR001664
Domain	Keratin_2_head	KRT3 KRT74 KRT73	8.18e-06	24	31	3	IPR032444
Domain	Keratin_2_head	KRT3 KRT74 KRT73	8.18e-06	24	31	3	PF16208
Domain	Keratin_II	KRT3 KRT74 KRT73	1.05e-05	26	31	3	IPR003054
Domain	Keratin_I	KRT3 KRT12 KRT13	5.24e-05	44	31	3	IPR002957
Domain	Tim17/Tim22/Tim23/PMP24	TIMM23 TIMM22	7.42e-05	8	31	2	IPR003397
Domain	Tim17	TIMM23 TIMM22	7.42e-05	8	31	2	PF02466
Pathway	REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE	KRT3 KRT12 KRT13 KRT74 KRT73	5.91e-06	129	29	5	M27649
Pathway	REACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE	KRT12 KRT13 KRT74 KRT73	2.86e-05	87	29	4	MM15351
Pathway	REACTOME_KERATINIZATION	KRT3 KRT12 KRT13 KRT74 KRT73	7.25e-05	217	29	5	M27640
Pathway	REACTOME_KERATINIZATION	KRT12 KRT13 KRT74 KRT73	2.56e-04	153	29	4	MM15343
Pathway	REACTOME_DEVELOPMENTAL_BIOLOGY	TCF3 KRT12 KRT13 MAPK7 KRT74 KRT73	4.67e-04	502	29	6	MM14537
Pathway	REACTOME_MRNA_SPLICING	PPIG GPATCH1 DHX9 HNRNPM	8.79e-04	212	29	4	M14033
Pubmed	New consensus nomenclature for mammalian keratins.	KRT3 KRT12 KRT13 KRT74 KRT73	3.78e-09	63	33	5	16831889
Pubmed	RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers.	KRT3 KRT13 KRT74 KRT73	2.56e-07	57	33	4	31862882
Pubmed	Mutations in cornea-specific keratin K3 or K12 genes cause Meesmann's corneal dystrophy.	KRT3 KRT12	8.73e-07	2	33	2	9171831
Pubmed	Human aniridia limbal epithelial cells lack expression of keratins K3 and K12.	KRT3 KRT12	8.73e-07	2	33	2	29162348
Pubmed	Novel mutations in the helix termination motif of keratin 3 and keratin 12 in 2 Taiwanese families with Meesmann corneal dystrophy.	KRT3 KRT12	8.73e-07	2	33	2	16227835
Pubmed	Autosomal-dominant Meesmann epithelial corneal dystrophy without an exon mutation in the keratin-3 or keratin-12 gene in a Chinese family.	KRT3 KRT12	8.73e-07	2	33	2	23569037
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	TIMM23 PPIG MAPK7 GTF3C1 GFPT1 DHX9 HNRNPM	2.27e-06	655	33	7	35819319
Pubmed	Transcription factor cycling on the insulin promoter.	TCF3 MAFA	2.62e-06	3	33	2	16412423
Pubmed	The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription.	DHX9 HNRNPM	5.23e-06	4	33	2	11823437
Pubmed	K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-specific type II epithelial keratins of the human hair follicle.	KRT74 KRT73	5.23e-06	4	33	2	12648212
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	KRT3 KRT12 KRT13 GTF3C1 RAB21 KRT74 KRT73 MAFA HNRNPM	5.53e-06	1442	33	9	35575683
Pubmed	PAX6 Isoforms, along with Reprogramming Factors, Differentially Regulate the Induction of Cornea-specific Genes.	KRT3 KRT12	8.72e-06	5	33	2	26899008
Pubmed	Protein-protein interaction panel using mouse full-length cDNAs.	CCDC91 TCF3 KRT13 TIMM22	1.63e-05	161	33	4	11591653
Pubmed	Identification of two novel proteins that interact with germ-cell-specific RNA-binding proteins DAZ and DAZL1.	DAZAP2 DAZAP1	1.83e-05	7	33	2	10857750
Pubmed	Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria.	TIMM23 TIMM22	1.83e-05	7	33	2	14726512
Pubmed	FAM188B enhances cell survival via interaction with USP7.	KRT3 KRT13 GTF3C1	3.27e-05	65	33	3	29795372
Pubmed	Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.	PPIG KRT13 DAZAP1 GFPT1 KRT73 DHX9	3.41e-05	665	33	6	30457570
Pubmed	Ubiquitin ligase MARCH8 promotes the malignant progression of hepatocellular carcinoma through PTEN ubiquitination and degradation.	DHX9 HNRNPM	3.91e-05	10	33	2	37098835
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	GTF3C1 DAZAP1 RAB21 GFPT1 DHX9 HNRNPM	4.68e-05	704	33	6	29955894
Pubmed	Eyelid closure in embryogenesis is required for ocular adnexa development.	KRT12 KRT13	4.78e-05	11	33	2	25377219
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	GTF3C1 GFPT1 GPATCH1 DHX9 HNRNPM	5.61e-05	440	33	5	34244565
Pubmed	Co-factors of LIM domains (Clims/Ldb/Nli) regulate corneal homeostasis and maintenance of hair follicle stem cells.	KRT12 COL17A1	5.73e-05	12	33	2	17991461
Pubmed	LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.	GTF3C1 DHX9 HNRNPM	5.86e-05	79	33	3	26446488
Pubmed	Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.	KRT3 KRT13 HNRNPM	7.04e-05	84	33	3	29563501
Pubmed	SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.	KRT74 MEX3D DHX9 HNRNPM	8.37e-05	245	33	4	35652658
Pubmed	TRIM25 and DEAD-Box RNA Helicase DDX3X Cooperate to Regulate RIG-I-Mediated Antiviral Immunity.	KRT13 GFPT1 HNRNPM	8.93e-05	91	33	3	34445801
Pubmed	Proteomic analysis of an interactome for long-form AMPA receptor subunits.	DHX9 HNRNPM	9.10e-05	15	33	2	20131911
Pubmed	Localization of basement membrane-associated protein isoforms during development of the ocular surface of mouse eye.	LAMA2 KRT12	9.10e-05	15	33	2	9264260
Pubmed	The genomic organization of type I keratin genes in mice.	KRT12 KRT13	9.10e-05	15	33	2	10087197
Pubmed	Inhibition of calpain 1 restores plasma membrane stability to pharmacologically rescued Phe508del-CFTR variant.	KRT12 KRT13 KRT74 GPATCH1 HNRNPM	9.14e-05	488	33	5	31324722
Pubmed	Cross-Linking Mass Spectrometry Uncovers Interactions Between High-Density Lipoproteins and the SARS-CoV-2 Spike Glycoprotein.	KRT3 KRT12 KRT73	9.23e-05	92	33	3	37343697
Pubmed	Stabilization of the methyl-CpG binding protein ZBTB38 by the deubiquitinase USP9X limits the occurrence and toxicity of oxidative stress in human cells.	DNAJB4 PPIG GTF3C1	1.01e-04	95	33	3	29490077
Pubmed	Beta-catenin interacts with the FUS proto-oncogene product and regulates pre-mRNA splicing.	DHX9 HNRNPM	1.04e-04	16	33	2	16230076
Pubmed	Comprehensive analysis of keratin gene clusters in humans and rodents.	KRT74 KRT73	1.04e-04	16	33	2	15085952
Pubmed	Charting the molecular network of the drug target Bcr-Abl.	KRT3 KRT12 KRT13 KRT73	1.15e-04	266	33	4	19380743
Pubmed	RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation.	DHX9 HNRNPM	1.32e-04	18	33	2	27558965
Pubmed	Histone-binding of DPF2 mediates its repressive role in myeloid differentiation.	TCF3 GFPT1 DHX9 HNRNPM	1.46e-04	283	33	4	28533407
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	KRT3 KRT13 COL17A1 GTF3C1 GFPT1 DHX9 HNRNPM	1.48e-04	1257	33	7	36526897
Pubmed	Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.	OBSCN KRT13 KRT74 KRT73 HNRNPM	1.80e-04	564	33	5	21565611
Pubmed	Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.	GTF3C1 DHX9 HNRNPM	1.83e-04	116	33	3	21549307
Pubmed	Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs.	DAZAP1 HNRNPM	1.99e-04	22	33	2	12456657
Pubmed	mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.	RAB21 GFPT1 DHX9 HNRNPM	2.12e-04	312	33	4	37120454
Pubmed	Interaction of Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and Vav3 in the Receptor Activator of Nuclear Factor κB (RANK) Signaling Complex Enhances Osteoclastogenesis.	KRT3 KRT12	2.38e-04	24	33	2	27507811
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	KRT3 KRT13 KRT73 DHX9 HNRNPM	2.49e-04	605	33	5	28977666
Pubmed	Shwachman-Bodian Diamond syndrome is a multi-functional protein implicated in cellular stress responses.	DHX9 HNRNPM	3.02e-04	27	33	2	19602484
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	TIMM23 DNAJB4 KRT13 DAZAP1 GFPT1 DHX9 HNRNPM	3.06e-04	1415	33	7	28515276
Pubmed	A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain.	DAZAP1 GPATCH1 DHX9 HNRNPM	3.17e-04	347	33	4	16033648
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	PPIG KRT12 DAZAP1 DHX9 HNRNPM	3.71e-04	660	33	5	32780723
Pubmed	Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase.	DAZAP2 HNRNPM	4.25e-04	32	33	2	23277564
Pubmed	BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62.	DNAJB4 GFPT1 HNRNPM	4.38e-04	156	33	3	32850835
Pubmed	In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.	KRT3 KRT13 RAB21 KRT74 KRT73 HNRNPM	4.54e-04	1070	33	6	23533145
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	PPIG GTF3C1 MEX3D DHX9 HNRNPM	5.27e-04	713	33	5	29802200
Pubmed	Endogenous human MDM2-C is highly expressed in human cancers and functions as a p53-independent growth activator.	DHX9 HNRNPM	5.39e-04	36	33	2	24147044
Pubmed	Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.	GTF3C1 DAZAP1 GFPT1 DHX9 HNRNPM	5.68e-04	725	33	5	27025967
Pubmed	Beads-free protein immunoprecipitation for a mass spectrometry-based interactome and posttranslational modifications analysis.	DAZAP1 DHX9 HNRNPM	5.81e-04	172	33	3	26336360
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	OBSCN GTF3C1 GFPT1 DHX9 HNRNPM	6.08e-04	736	33	5	29676528
Pubmed	Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing.	DHX9 HNRNPM	6.66e-04	40	33	2	23825951
Pubmed	The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.	KRT3 KRT13 KRT74 KRT73 DHX9 HNRNPM	6.74e-04	1153	33	6	29845934
Pubmed	Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.	CCDC91 GFPT1 DHX9	6.85e-04	182	33	3	32239614
Pubmed	A HIV-1 Tat mutant protein disrupts HIV-1 Rev function by targeting the DEAD-box RNA helicase DDX1.	DHX9 HNRNPM	8.43e-04	45	33	2	25496916
Pubmed	Dynamic protein-protein interaction wiring of the human spliceosome.	PPIG DHX9 HNRNPM	8.62e-04	197	33	3	22365833
Pubmed	PIP30/FAM192A is a novel regulator of the nuclear proteasome activator PA28γ.	DHX9 HNRNPM	9.19e-04	47	33	2	29934401
Pubmed	A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation.	DHX9 HNRNPM	9.19e-04	47	33	2	32160526
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	PPIG DAZAP1 MEX3D DHX9 HNRNPM	9.20e-04	807	33	5	22681889
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	DNAJB4 GTF3C1 DAZAP1 HNRNPM	9.27e-04	462	33	4	31138677
Interaction	RNF208 interactions	KRT3 DAZAP2 KRT13 KRT74 KRT73	1.36e-07	75	33	5	int:RNF208
Interaction	KRT84 interactions	KRT3 KRT12 KRT74 KRT73	1.20e-06	49	33	4	int:KRT84
Interaction	KRT6A interactions	KRT3 KRT12 KRT13 KRT74 KRT73	5.88e-06	160	33	5	int:KRT6A
Interaction	KRT5 interactions	KRT3 KRT12 KRT13 KRT74 KRT73	1.46e-05	193	33	5	int:KRT5
Interaction	RABGEF1 interactions	DAZAP2 TCF3 DAZAP1 RAB21 DHX9	1.91e-05	204	33	5	int:RABGEF1
Interaction	KRT25 interactions	KRT3 KRT74 KRT73	2.53e-05	35	33	3	int:KRT25
Interaction	ATXN1 interactions	OBSCN DAZAP2 PPIG KRT13 DAZAP1 GFPT1 TENT5A KRT73 DHX9	3.12e-05	1039	33	9	int:ATXN1
Interaction	DES interactions	KRT3 KRT12 KRT13 KRT73	1.25e-04	158	33	4	int:DES
Interaction	DAZ1 interactions	DAZAP2 DAZAP1	1.42e-04	11	33	2	int:DAZ1
Interaction	RICTOR interactions	TCF3 GTF3C1 RAB21 GFPT1 GPATCH1 DHX9 HNRNPM	1.90e-04	759	33	7	int:RICTOR
Interaction	IVNS1ABP interactions	TCF3 MAPK7 DHX9 HNRNPM	2.06e-04	180	33	4	int:IVNS1ABP
Interaction	KRT75 interactions	KRT3 KRT12 KRT13 KRT73	2.10e-04	181	33	4	int:KRT75
Interaction	MINDY4 interactions	KRT3 KRT13 GTF3C1	2.30e-04	73	33	3	int:MINDY4
Interaction	KRT36 interactions	KRT3 KRT74 KRT73	2.40e-04	74	33	3	int:KRT36
Interaction	KRT16 interactions	KRT3 KRT74 KRT73 HNRNPM	2.90e-04	197	33	4	int:KRT16
Interaction	RNF44 interactions	DAZAP2 TENT5A	3.08e-04	16	33	2	int:RNF44
Interaction	CRK interactions	KRT3 KRT12 GFPT1 KRT73 DHX9	3.16e-04	370	33	5	int:CRK
Interaction	HOOK3 interactions	KRT13 RAB21 GFPT1 GPATCH1	3.19e-04	202	33	4	int:HOOK3
Cytoband	Ensembl 112 genes in cytogenetic band chr12q13	KRT3 DAZAP2 KRT74 KRT73	2.35e-04	423	33	4	chr12q13
Cytoband	12q12	DAZAP2 SLC2A13	5.31e-04	47	33	2	12q12
Cytoband	19p13.3	TCF3 DAZAP1 MEX3D	6.61e-04	237	33	3	19p13.3
Cytoband	12q13.13	KRT3 KRT74	1.08e-03	67	33	2	12q13.13
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	TCF3 DAZAP1 MEX3D HNRNPM	2.47e-03	797	33	4	chr19p13
GeneFamily	Keratins, type II	KRT3 KRT74 KRT73	7.55e-06	27	26	3	609
GeneFamily	Keratins, type I	KRT12 KRT13	7.35e-04	28	26	2	608
ToppCell	IIH-CD8-naive_CD4\|IIH / Condition, Cell_class and T cell subcluster	OBSCN DUOX1 MARVELD3 GPATCH1	7.92e-06	173	33	4	4f2843371d18af766c1892529ce286f56c956fde
ToppCell	PND01-03-samps-Mesenchymal-Myofibroblast-MyoFB-3\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	LAMA2 SLC2A13 KCNE4	1.35e-04	135	33	3	5b13ff740d9f7d96274aebb6b389a80f6004adc7
ToppCell	Transplant_Alveoli_and_parenchyma-Epithelial-Basal_2\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	KRT13 COL17A1 MAFA	1.95e-04	153	33	3	a44da11a913b19edde6c5d1d6e625c24b20ecbfd
ToppCell	severe_COVID-19-MAIT\|World / disease group, cell group and cell class (v2)	OBSCN GTF3C1 MAFA	1.99e-04	154	33	3	65ec7f7ef05c589903c4c9fe3849478c325fdc61
ToppCell	wk_15-18-Epithelial-Proximal_epithelial-basal_intermediate_\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	DUOX1 KRT13 COL17A1	2.15e-04	158	33	3	98712ed7e8e65e8c5ff9318cf0e0a04e271a055d
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 KCNE4 TENT5A	2.19e-04	159	33	3	2607b562903228274fbd96168ba826782fab0b53
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 KCNE4 TENT5A	2.19e-04	159	33	3	e812cbde59188924c6277c3feadf1a9592fa62a4
ToppCell	facs-Marrow-Granulocytes-3m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA2 DNAJB4 KRT13	2.23e-04	160	33	3	8590281165eab6514a9f6a022b900d4c222c1044
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	OBSCN LAMA2 KCNE4	2.57e-04	168	33	3	d2b91f2adc95dcfa623f8d7ca2df1c6f884da988
ToppCell	PND07-Epithelial-Epithelial_Airway-Basal-Basal-Basal_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DUOX1 KRT13 COL17A1	2.80e-04	173	33	3	1b2508cc890430bd4b2cf232c633928edb86c57e
ToppCell	Healthy-Plasmablast\|World / disease group, cell group and cell class	TAS1R1 TCF3 KCNE4	2.85e-04	174	33	3	6becb456d8f44a1224c6d42be78d4c8cdb51f199
ToppCell	5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	OBSCN LAMA2 KCNE4	2.99e-04	177	33	3	bd602db857f37869ef76d14c05ef522c509f08ee
ToppCell	droplet-Fat-Scat-21m-Mesenchymal-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN DUOX1 COL17A1	3.04e-04	178	33	3	5fc9f41609735b972a2cd0830182d13742cd5bf5
ToppCell	NS-critical-d_0-4-Myeloid-Mast_cell\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TIMM22 TENT5A GPATCH1	3.09e-04	179	33	3	6153e7a0eeae83e7d88f1a20093bf2113e8d66b1
ToppCell	PND07-Epithelial-Epithelial_Airway-Basal-Basal\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DUOX1 KRT13 COL17A1	3.20e-04	181	33	3	6b43dcaeeb02ad5900772b6f16f1581847050e38
ToppCell	PND07-Epithelial-Epithelial_Airway-Basal\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DUOX1 KRT13 COL17A1	3.20e-04	181	33	3	f50561fdacfb83ba85fe6476e7cbc2bad1ebc826
ToppCell	LV-15._Ventricular_Cardiomyocyte_III\|LV / Chamber and Cluster_Paper	OBSCN LAMA2 TENT5A	3.35e-04	184	33	3	ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_A\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	GTF3C1 TENT5A KRT73	3.41e-04	185	33	3	25781cf68e693e97dc1885e2879ab24fa946b51e
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|RV / Chamber and Cluster_Paper	OBSCN LAMA2 TENT5A	3.68e-04	190	33	3	93c3188dfeb0b2f9889f8ae9b9c1f2f34129c99b
ToppCell	PBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	COL17A1 MBOAT2 TENT5A	3.74e-04	191	33	3	6c1283d51a845cff67ed5e500f7e944165297b53
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 KCNE4 TENT5A	3.74e-04	191	33	3	7b0d42a877540dbb346a76a62403e0d5d3e07fa6
ToppCell	droplet-Lung-21m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l49\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LAMA2 DNAJB4 KCNE4	3.74e-04	191	33	3	c715bbdbbf1482aad45a50a16d5232fd35a9a0bb
ToppCell	droplet-Lung-21m-Mesenchymal-fibroblast-alveolar_fibroblast\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LAMA2 DNAJB4 KCNE4	3.74e-04	191	33	3	243d83cbfcc4996ad087ec6386e559e0b8662004
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 KCNE4 TENT5A	3.74e-04	191	33	3	cd854b9c426924fdc84bf7f411f6dea447143e79
ToppCell	droplet-Lung-nan-18m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA2 DNAJB4 KCNE4	3.80e-04	192	33	3	df56c3e3bb1aafc1126607f4426554c09c8c40cf
ToppCell	droplet-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l49\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LAMA2 KCNE4 COL17A1	3.80e-04	192	33	3	1b228f0929b505de82a39bf64c837887b0e56701
ToppCell	PBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	COL17A1 MBOAT2 TENT5A	3.80e-04	192	33	3	86d561c30554ff04c21801d4aaf8e3c9efe49af4
ToppCell	COVID-19_Severe-Myeloid_G-immature_Neutrophil\|COVID-19_Severe / Disease group, lineage and cell class	COL17A1 MBOAT2 TENT5A	3.80e-04	192	33	3	303deb68da2e4a75e6ee5a79478182a8bc41c7c5
ToppCell	mild-Myeloid-Immature_Neutrophils_2\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	COL17A1 MBOAT2 TENT5A	3.80e-04	192	33	3	0445fdc670fa7b847dcd0a061d7736ddcf3519ba
ToppCell	PBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil-Neu_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	COL17A1 MBOAT2 TENT5A	3.86e-04	193	33	3	ccab6a0c76f574ef7e1d6d5f1e620376daf21bbf
ToppCell	PBMC-Severe-Myeloid-Neutrophil-immature_Neutrophil-Neu_4\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	COL17A1 MBOAT2 TENT5A	3.92e-04	194	33	3	23318a1b55895b5166c6151f488a94a09b4627ff
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 KCNE4 TENT5A	3.92e-04	194	33	3	ba7f971fb9a19423602da60770f23d9fead4a451
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 KCNE4 TENT5A	3.92e-04	194	33	3	cf0244a29934e515446ac917d3c30672b460fb04
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Epithelial-TECs\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DUOX1 KRT13 COL17A1	3.97e-04	195	33	3	17c4d3b59cd0d79ce9ae5dde95586f3e923db16f
ToppCell	5'-Adult-SmallIntestine-Epithelial-Tuft-related-BEST4+_epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KRT13 KRT74 KRT73	3.97e-04	195	33	3	e87b11e3242fdbed2e7f383e6876ec375af32bd4
ToppCell	5'-Adult-SmallIntestine-Epithelial-Tuft-related\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KRT13 KRT74 KRT73	3.97e-04	195	33	3	23ab7e2a419377c05bab0e92a2457afbcd3d9e07
ToppCell	facs-Pancreas-Endocrine-18m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC2A13 GFPT1 MAFA	3.97e-04	195	33	3	bd8e24dd598990204998d1dd853ba7a53dc0107e
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Epithelial-epithelial_cell_of_thymus\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DUOX1 KRT13 COL17A1	3.97e-04	195	33	3	66caa5c063184e7d3d653c8f6c289555cb36fa82
ToppCell	facs-Tongue\|facs / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DUOX1 KRT13 COL17A1	3.97e-04	195	33	3	77128895db9221a64a171082d468ebcd6380c936
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Epithelial\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DUOX1 KRT13 COL17A1	3.97e-04	195	33	3	ed74c113074fb5d3c42f2330b0e6042d32c3611a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 KCNE4 TENT5A	4.03e-04	196	33	3	b8759e6231e0254797d6c30930407b79440c57bb
ToppCell	CV-Moderate-6\|CV / Virus stimulation, Condition and Cluster	CCDC91 PPIG GTF3C1	4.03e-04	196	33	3	7bced0cc2112697593c478fa291b8ed3941fb811
ToppCell	10x3'2.3-week_17-19\|World / cell types per 3 fetal stages;per 3',per 5'	TCF3 RAB21 MAFA	4.09e-04	197	33	3	f5cfad0b42d0f817e22cc78b9bfb2b4b7e4330ed
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_A\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	DNAJB4 RAB21 TENT5A	4.09e-04	197	33	3	cd54e6ad175529327fa0372033016b3b978dd452
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA2 KCNE4 TENT5A	4.16e-04	198	33	3	79576525a10ed3e3a9d1608077cd16ecda23376f
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	OBSCN DUOX1 COL17A1	4.16e-04	198	33	3	5374b0e98d669f36a0571d3c006c7bd5e3c8e87f
ToppCell	Sepsis-Int-URO-Lymphocyte-T/NK-CD8+_T_naive\|Int-URO / Disease, condition lineage and cell class	OBSCN TCF3 KRT73	4.16e-04	198	33	3	8c7d00d8c27fb47954d8ac53eebc4582e92b970c
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_basal-Basal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	OBSCN DUOX1 COL17A1	4.22e-04	199	33	3	94a7867e800df352731796de8c24cba133c29622
ToppCell	(04)_Interm._basal>secr.-(1)_GFP\|(04)_Interm._basal>secr. / shred by cell type by condition	KRT13 COL17A1 MBOAT2	4.22e-04	199	33	3	7a0d40d4679dc373829d67693851428f41c8b0d6
ToppCell	distal-1-Epithelial-Proliferating_Basal\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KRT13 MARVELD3 COL17A1	4.22e-04	199	33	3	93450257180d918c310bca7b5defc74390c48091
ToppCell	distal-Epithelial-Proliferating_Basal-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KRT13 MARVELD3 COL17A1	4.28e-04	200	33	3	cc31e8c28d01e6757c5dd7f485db6acf7409a47e
ToppCell	distal-mesenchymal-Pericyte-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	OBSCN LAMA2 TENT5A	4.28e-04	200	33	3	867935701fac71a3fe01578362da0676f959736c
ToppCell	distal-Epithelial-Proliferating_Basal\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	KRT13 MARVELD3 COL17A1	4.28e-04	200	33	3	25cc494ef831511840d8c02ec1bd086635cc7edd
ToppCell	Parenchymal-10x5prime-Stromal-Peri/Epineurial_-NAF_endoneurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	OBSCN LAMA2 KCNE4	4.28e-04	200	33	3	8a4c210a3130f7baedf15ecbc0f4903b97da0352
ToppCell	distal-2-mesenchymal-Pericyte\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	LAMA2 KCNE4 TENT5A	4.28e-04	200	33	3	4ee0b2f56c2652435fa78bf6b3c90cea28df74e0
Drug	al-Badry	KRT3 KRT12 KRT13 GTF3C1 KRT74 KRT73	1.03e-07	165	32	6	CID000004545
Drug	teleocidin B	KRT3 KRT12 KRT13 KRT74 KRT73	7.60e-07	123	32	5	CID000072425
Drug	sulfur mustard	KRT3 KRT12 KRT13 KRT74 KRT73	9.99e-07	130	32	5	CID000010461
Drug	homocysteine thiolactone	KRT3 KRT12 KRT13 KRT74 KRT73	1.04e-06	131	32	5	CID000107712
Drug	AC1L9MJT	KRT3 KRT12 KRT13 COL17A1 KRT74	6.77e-06	192	32	5	CID000448959
Drug	butyrate	LAMA2 KRT3 KRT12 KRT13 SLC2A13 GTF3C1 KRT74 KRT73	8.20e-06	767	32	8	CID000000264
Drug	Velcade (bortezomib	KRT3 KRT12 KRT13 MAPK7 KRT74 KRT73	1.19e-05	374	32	6	CID000093860
Drug	chrysene	DNAJB4 PPIG KRT13 MARVELD3 COL17A1 GTF3C1 MBOAT2 GPATCH1	2.06e-05	871	32	8	ctd:C031180
Drug	liarozole	PPIG KRT13 DHX9	2.23e-05	39	32	3	CID000060652
Drug	CTFE	KRT3 KRT12 KRT13	3.67e-05	46	32	3	CID000006594
Disease	Corneal Dystrophy, Juvenile Epithelial of Meesmann	KRT3 KRT12	1.14e-06	2	32	2	C0339277
Disease	Meesmann corneal dystrophy	KRT3 KRT12	1.14e-06	2	32	2	cv:C0339277
Disease	bone quantitative ultrasound measurement	CCDC91 GPATCH1	8.23e-04	39	32	2	EFO_0004514
Disease	estrogen-receptor negative breast cancer	CCDC91 TENT5A	2.70e-03	71	32	2	EFO_1000650

Protein segments in the cluster

Peptide	Gene	Start	Entry
YAGNGGLLGADFAGD	COL17A1	1356	Q9UMD9
GYGQDLSGFGQGFSD	DAZAP1	351	Q96EP5
GGGGGAAAAGRAYSF	RAB21	6	Q9UL25
AAGAAGDGVAAGGDY	GOLGA8F;	321	Q08AF8
DYFEGSGFGFGVTIG	DUOX1	586	Q9NRD9
GSGAGYGVGFDLEEF	MAPK7	736	Q13164
VEGGYDAGARFGAGA	DAZAP2	106	Q15038
AAGGGSGNGNEYFYI	KCNE4	76	Q8WWG9
AAYEAFRGPGFAGGG	MAFA	161	Q8NHW3
AGTGAGFGFSNAGTY	KRT73	466	Q86Y46
AFGFGASCGGGFSAA	KRT12	46	Q99456
AAGFGFRGYDENGAA	MBOAT2	301	Q6ZWT7
CVAHSGGAGGGAYGF	KRT3	31	P12035
ERGNFGGSFAGSFGG	HNRNPM	626	P52272
FGGGFAGGFVDFGAC	KRT13	81	P13646
GAFSGGFSAGYFNTV	GPATCH1	51	Q9BRR8
ASPYSGSGNGGFAFG	MEX3D	421	Q86XN8
GTYFDGTGFAKAVGG	LAMA2	2941	P24043
EGNGRGGESIYGGFF	PPIG	81	Q13427
AGVAGYGTFAFGGDA	OBSCN	7186	Q5VST9
YGTFAFGGDAGGMLG	OBSCN	7191	Q5VST9
AGGTDGQGGTFRYTF	DNAJB4	76	Q9UDY4
AAGAAGDGVAAGGDY	GOLGA8DP	321	Q0D2H9
FGGFEAAETFDGGSG	CCDC91	6	Q7Z6B0
GGAYSGFDGADGEKA	MARVELD3	241	Q96A59
GSANSFRAGYGAGVG	DHX9	1201	Q08211
GGFLFGYDTGVVSGA	SLC2A13	91	Q96QE2
EYRGYDSAGVGFDGG	GFPT1	31	Q06210
SLAAGSGSLYGFFGE	TAS1R1	611	Q7RTX1
GAYASFGRDAGVGGL	TCF3	106	P15923
ACVGGFVLGGAFGVF	TIMM22	76	Q9Y584
GDGLGAAGLDSSFYG	GTF3C1	1111	Q12789
DFGGGGSFGGHCLDY	TENT5A	41	Q96IP4
AGFFGAGGAGYSHAD	TIMM23	16	O14925
FNVAGGGVRAGGYGF	KRT74	61	Q7RTS7