Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionendopolyphosphatase activity

NUDT11 NUDT4 NUDT10

3.28e-075653GO:0000298
GeneOntologyMolecularFunctionbis(5'-adenosyl)-hexaphosphatase activity

NUDT11 NUDT4 NUDT10

3.28e-075653GO:0034431
GeneOntologyMolecularFunctiondiphosphoinositol-polyphosphate diphosphatase activity

NUDT11 NUDT4 NUDT10

3.28e-075653GO:0008486
GeneOntologyMolecularFunctionbis(5'-adenosyl)-pentaphosphatase activity

NUDT11 NUDT4 NUDT10

6.54e-076653GO:0034432
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

DOCK5 RAPGEF6 DOCK7 MCF2L DOCK6

9.32e-04231655GO:0005085
GeneOntologyMolecularFunctionmuscle alpha-actinin binding

LDB3 MYPN

1.07e-0315652GO:0051371
GeneOntologyMolecularFunction1-phosphatidylinositol binding

ZFYVE9 MCF2L

1.37e-0317652GO:0005545
GeneOntologyBiologicalProcessadenosine 5'-(hexahydrogen pentaphosphate) metabolic process

NUDT11 NUDT4 NUDT10

3.12e-075663GO:1901910
GeneOntologyBiologicalProcessadenosine 5'-(hexahydrogen pentaphosphate) catabolic process

NUDT11 NUDT4 NUDT10

3.12e-075663GO:1901911
GeneOntologyBiologicalProcessdiadenosine pentaphosphate catabolic process

NUDT11 NUDT4 NUDT10

3.12e-075663GO:1901907
GeneOntologyBiologicalProcessdiadenosine pentaphosphate metabolic process

NUDT11 NUDT4 NUDT10

3.12e-075663GO:1901906
GeneOntologyBiologicalProcessdiadenosine hexaphosphate catabolic process

NUDT11 NUDT4 NUDT10

3.12e-075663GO:1901909
GeneOntologyBiologicalProcessdiadenosine hexaphosphate metabolic process

NUDT11 NUDT4 NUDT10

3.12e-075663GO:1901908
GeneOntologyBiologicalProcessdiphosphoinositol polyphosphate metabolic process

NUDT11 NUDT4 NUDT10

3.12e-075663GO:0071543
GeneOntologyBiologicalProcessdiadenosine polyphosphate catabolic process

NUDT11 NUDT4 NUDT10

6.22e-076663GO:0015961
GeneOntologyBiologicalProcessdiadenosine polyphosphate metabolic process

NUDT11 NUDT4 NUDT10

2.59e-069663GO:0015959
DomainDOCK_C

DOCK5 DOCK7 DOCK6

6.51e-0611653IPR010703
DomainDHR-1_domain

DOCK5 DOCK7 DOCK6

6.51e-0611653IPR027007
DomainDHR_2

DOCK5 DOCK7 DOCK6

6.51e-0611653PS51651
DomainDHR_1

DOCK5 DOCK7 DOCK6

6.51e-0611653PS51650
DomainDOCK-C2

DOCK5 DOCK7 DOCK6

6.51e-0611653PF14429
DomainDHR-2

DOCK5 DOCK7 DOCK6

6.51e-0611653IPR027357
DomainDHR-2

DOCK5 DOCK7 DOCK6

6.51e-0611653PF06920
DomainDOCK

DOCK5 DOCK7 DOCK6

6.51e-0611653IPR026791
DomainNUDIX_hydrolase_CS

NUDT11 NUDT4 NUDT10

8.65e-0612653IPR020084
DomainZINC_FINGER_C2H2_2

IKZF2 ZNF684 FEZF2 ZNF549 ZNF804B ZNF70 IKZF1 ZNF721 ZNF223 ZNF230 ZBTB24 ZNF284

1.27e-057756512PS50157
DomainZINC_FINGER_C2H2_1

IKZF2 ZNF684 FEZF2 ZNF549 ZNF804B ZNF70 IKZF1 ZNF721 ZNF223 ZNF230 ZBTB24 ZNF284

1.31e-057776512PS00028
DomainZnf_C2H2-like

IKZF2 ZNF684 FEZF2 ZNF549 ZNF804B ZNF70 IKZF1 ZNF721 ZNF223 ZNF230 ZBTB24 ZNF284

1.66e-057966512IPR015880
DomainZnf_C2H2

IKZF2 ZNF684 FEZF2 ZNF549 ZNF804B ZNF70 IKZF1 ZNF721 ZNF223 ZNF230 ZBTB24 ZNF284

1.86e-058056512IPR007087
DomainZnF_C2H2

IKZF2 ZNF684 FEZF2 ZNF549 ZNF804B ZNF70 IKZF1 ZNF721 ZNF223 ZNF230 ZBTB24 ZNF284

1.93e-058086512SM00355
Domain-

IKZF2 ZNF684 FEZF2 ZNF549 ZNF70 IKZF1 ZNF721 ZNF223 ZNF230 ZBTB24 ZNF284

2.02e-0567965113.30.160.60
Domainzf-C2H2

IKZF2 ZNF684 FEZF2 ZNF549 ZNF70 IKZF1 ZNF721 ZNF223 ZNF230 ZBTB24 ZNF284

2.44e-056936511PF00096
DomainZnf_C2H2/integrase_DNA-bd

IKZF2 ZNF684 FEZF2 ZNF549 ZNF70 IKZF1 ZNF721 ZNF223 ZNF230 ZBTB24 ZNF284

2.48e-056946511IPR013087
DomainNUDIX_BOX

NUDT11 NUDT4 NUDT10

7.73e-0524653PS00893
DomainNUDIX

NUDT11 NUDT4 NUDT10

7.73e-0524653PF00293
DomainNUDIX

NUDT11 NUDT4 NUDT10

9.88e-0526653PS51462
Domain-

NUDT11 NUDT4 NUDT10

1.24e-04286533.90.79.10
DomainNUDIX_hydrolase_dom-like

NUDT11 NUDT4 NUDT10

1.24e-0428653IPR015797
DomainNUDIX_hydrolase_dom

NUDT11 NUDT4 NUDT10

1.38e-0429653IPR000086
DomainDUF3398

DOCK7 DOCK6

1.77e-046652PF11878
DomainDOCK_C/D_N

DOCK7 DOCK6

1.77e-046652IPR021816
DomainZnf_FYVE

RUFY2 ZFYVE9 SYTL4

3.11e-0438653IPR000306
DomainZF_FYVE

RUFY2 ZFYVE9 SYTL4

3.63e-0440653PS50178
Domainzf-C2H2_6

ZNF684 FEZF2 ZNF549 ZNF721 ZBTB24 ZNF284

7.73e-04314656PF13912
DomainPDZ

LDB3 RAPGEF6 LNX2 MYO18A

1.48e-03141654PF00595
DomainPDZ

LDB3 RAPGEF6 LNX2 MYO18A

1.76e-03148654SM00228
Domain-

LDB3 RAPGEF6 LNX2 MYO18A

1.85e-031506542.30.42.10
DomainPDZ

LDB3 RAPGEF6 LNX2 MYO18A

1.90e-03151654PS50106
DomainPDZ

LDB3 RAPGEF6 LNX2 MYO18A

1.94e-03152654IPR001478
DomainFYVE

RUFY2 ZFYVE9

4.56e-0329652PF01363
DomainFYVE

RUFY2 ZFYVE9

4.56e-0329652SM00064
Domain-

RUFY2 TRAF6 LNX2 ZFYVE9 SYTL4 USP3

4.66e-034496563.30.40.10
DomainZnf_RING/FYVE/PHD

RUFY2 TRAF6 LNX2 ZFYVE9 SYTL4 USP3

5.18e-03459656IPR013083
DomainRA

RAPGEF6 GRB10

5.20e-0331652SM00314
DomaincNMP

RAPGEF6 PNPLA7

6.23e-0334652SM00100
DomainZnf_FYVE-rel

RUFY2 ZFYVE9

6.23e-0334652IPR017455
DomaincNMP_binding

RAPGEF6 PNPLA7

6.23e-0334652PF00027
DomaincNMP-bd_dom

RAPGEF6 PNPLA7

6.59e-0335652IPR000595
DomainCNMP_BINDING_3

RAPGEF6 PNPLA7

6.59e-0335652PS50042
DomainRA

RAPGEF6 GRB10

6.96e-0336652PF00788
DomainRA

RAPGEF6 GRB10

7.34e-0337652PS50200
DomainMyosin_head_motor_dom

MYO18A MYO1B

7.73e-0338652IPR001609
DomaincNMP-bd-like

RAPGEF6 PNPLA7

7.73e-0338652IPR018490
DomainMYOSIN_MOTOR

MYO18A MYO1B

7.73e-0338652PS51456
DomainMyosin_head

MYO18A MYO1B

7.73e-0338652PF00063
DomainMYSc

MYO18A MYO1B

7.73e-0338652SM00242
DomainKRAB

ZNF684 ZNF549 ZNF223 ZNF230 ZNF284

8.12e-03358655PS50805
DomainKRAB

ZNF684 ZNF549 ZNF223 ZNF230 ZNF284

8.12e-03358655PF01352
DomainRA_dom

RAPGEF6 GRB10

8.54e-0340652IPR000159
DomainKRAB

ZNF684 ZNF549 ZNF223 ZNF230 ZNF284

9.18e-03369655SM00349
DomainKRAB

ZNF684 ZNF549 ZNF223 ZNF230 ZNF284

9.29e-03370655IPR001909
PathwayREACTOME_SYNTHESIS_OF_PYROPHOSPHATES_IN_THE_CYTOSOL

NUDT11 NUDT4 NUDT10

4.10e-0610473MM14709
PathwayREACTOME_SYNTHESIS_OF_PYROPHOSPHATES_IN_THE_CYTOSOL

NUDT11 NUDT4 NUDT10

4.10e-0610473M27051
Pubmed

Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases.

NUDT11 NUDT4 NUDT10

6.53e-09366312121577
Pubmed

Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate.

NUDT11 NUDT4 NUDT10

2.61e-08466312370170
Pubmed

Paternal deletion of Meg1/Grb10 DMR causes maternalization of the Meg1/Grb10 cluster in mouse proximal Chromosome 11 leading to severe pre- and postnatal growth retardation.

GRB10 IKZF1 DDC

6.51e-08566319174477
Pubmed

Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations.

GRB10 IKZF1 DDC

6.51e-08566323512250
Pubmed

Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.

DOCK5 DOCK7 DOCK6

2.34e-061466312432077
Pubmed

Germline genomic variants associated with childhood acute lymphoblastic leukemia.

IKZF1 ZNF230 DDC

2.92e-061566319684603
Pubmed

An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase.

NUDT11 NUDT10

3.55e-06266212105228
Pubmed

Helios deficiency has minimal impact on T cell development and function.

IKZF2 IKZF1

3.55e-06266219620299
Pubmed

A genetic locus in 7p12.2 associated with treatment resistant schizophrenia.

GRB10 DDC

3.55e-06266225223841
Pubmed

Localization of endogenous Grb10 to the mitochondria and its interaction with the mitochondrial-associated Raf-1 pool.

RAF1 GRB10

3.55e-06266210585452
Pubmed

Paralogous murine Nudt10 and Nudt11 genes have differential expression patterns but encode identical proteins that are physiologically competent diphosphoinositol polyphosphate phosphohydrolases.

NUDT11 NUDT10

3.55e-06266212689335
Pubmed

Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytes.

IKZF2 IKZF1

3.55e-06266217681952
Pubmed

[Expression characteristics of isoforms of Ikaros and Helios in patients with leukemia and their mechanism].

IKZF2 IKZF1

3.55e-06266222931634
Pubmed

Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters.

ZNF223 ZNF230 ZNF284

7.27e-062066312743021
Pubmed

Tissue-specific Grb10/Ddc insulator drives allelic architecture for cardiac development.

GRB10 DDC

1.06e-05366236108632
Pubmed

Overexpression of novel short isoforms of Helios in a patient with T-cell acute lymphoblastic leukemia.

IKZF2 IKZF1

1.06e-05366211937265
Pubmed

Genomic imprinting of Dopa decarboxylase in heart and reciprocal allelic expression with neighboring Grb10.

GRB10 DDC

1.06e-05366217967881
Pubmed

Ubiquitin-specific protease 3 targets TRAF6 for deubiquitination and suppresses IL-1β induced chondrocyte apoptosis.

TRAF6 USP3

1.06e-05366231056254
Pubmed

Results of Detailed Investigations Into Stevens-Johnson Syndrome With Severe Ocular Complications.

TLR3 IKZF1

1.06e-05366230481825
Pubmed

Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors.

IKZF2 IKZF1

1.06e-0536629560339
Pubmed

Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases.

RAF1 GRB10

1.06e-0536629553107
Pubmed

Imprinted Gene Expression and Function of the Dopa Decarboxylase Gene in the Developing Heart.

GRB10 DDC

1.06e-05366234239874
Pubmed

Analysis of Ikaros family splicing variants in human hematopoietic lineages.

IKZF2 IKZF1

1.06e-05366220432734
Pubmed

Expression patterns of Ikaros family members during positive selection and lineage commitment of human thymocytes.

IKZF2 IKZF1

1.06e-05366227502439
Pubmed

Co-existence of IL7R high and SH2B3 low expression distinguishes a novel high-risk acute lymphoblastic leukemia with Ikaros dysfunction.

IKZF1 IL7R

1.06e-05366227322554
Pubmed

Autophagy facilitates TLR4- and TLR3-triggered migration and invasion of lung cancer cells through the promotion of TRAF6 ubiquitination.

TRAF6 TLR3

1.06e-05366224321786
Pubmed

Aberrant Ikaros, Aiolos, and Helios expression in Hodgkin and non-Hodgkin lymphoma.

IKZF2 IKZF1

1.06e-05366218332232
Pubmed

Distinct physiological and behavioural functions for parental alleles of imprinted Grb10.

GRB10 DDC

2.12e-05466221270893
Pubmed

STAT5 activation underlies IL7 receptor-dependent B cell development.

RAF1 IL7R

2.12e-05466215067053
Pubmed

Grb10 and active Raf-1 kinase promote Bad-dependent cell survival.

RAF1 GRB10

2.12e-05466217535812
Pubmed

Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.

NUDT11 NUDT10

3.53e-05566218264098
Pubmed

Activated interleukin-7 receptor signaling drives B-cell acute lymphoblastic leukemia in mice.

IKZF1 IL7R

3.53e-05566234193976
Pubmed

Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons.

TRAF6 TLR3

3.53e-05566223042151
Pubmed

Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities.

IKZF2 IKZF1

3.53e-05566210978333
Pubmed

Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family of dedicator of cytokinesis (DOCK) proteins.

DOCK5 DOCK7

3.53e-05566222158624
Pubmed

IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination.

TRAF6 TLR3

3.53e-05566217878161
Pubmed

Contributions of IKZF1, DDC, CDKN2A, CEBPE, and LMO1 Gene Polymorphisms to Acute Lymphoblastic Leukemia in a Yemeni Population.

IKZF1 DDC

3.53e-05566228768142
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

DOCK5 MYO18A DOCK7 MYO1B DOCK6

4.22e-0520266533005030
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

STK36 RAPGEF6 CTDP1 NPRL3 GRB10 JOSD1 MCF2L DOCK6 SIL1 PCNT

4.22e-051105661035748872
Pubmed

Discovery and refinement of loci associated with lipid levels.

RAF1 DOCK7 FADS2 IKZF1 DOCK6

5.19e-0521166524097068
Pubmed

JNK-binding protein 1 regulates NF-kappaB activation through TRAF2 and TAK1.

RAF1 TRAF6

5.29e-05666219385034
Pubmed

TLR3/TRIF signalling pathway regulates IL-32 and IFN-β secretion through activation of RIP-1 and TRAF in the human cornea.

TRAF6 TLR3

5.29e-05666225754842
Pubmed

IRF-8/interferon (IFN) consensus sequence-binding protein is involved in Toll-like receptor (TLR) signaling and contributes to the cross-talk between TLR and IFN-gamma signaling pathways.

TRAF6 TLR3

7.40e-05766216484229
Pubmed

Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway.

TRAF6 TLR3

7.40e-05766220047764
Pubmed

MyD88-dependent and -independent murine cytomegalovirus sensing for IFN-alpha release and initiation of immune responses in vivo.

TLR3 IKZF1

7.40e-05766216272328
Pubmed

Oligomerized TICAM-1 (TRIF) in the cytoplasm recruits nuclear BS69 to enhance NF-kappaB activation and type I IFN induction.

TRAF6 TLR3

9.86e-05866219795416
Pubmed

Stage-specific control of early B cell development by the transcription factor Ikaros.

IKZF1 IL7R

9.86e-05866224509509
Pubmed

WDFY1 mediates TLR3/4 signaling by recruiting TRIF.

TRAF6 TLR3

9.86e-05866225736436
Pubmed

MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2.

TRAF6 TLR3

9.86e-05866219596990
Pubmed

Genomic organization of the region spanning D14Mit262 and D14Mit86 on mouse chromosome 14 and exclusion of Adam28 and Adamdec1 as the cataract-causing gene, lr2.

DOCK5 ADAMDEC1

9.86e-05866217268172
Pubmed

Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation.

TRAF6 TLR3

9.86e-05866216115877
Pubmed

The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.

TRAF6 TLR3

1.27e-04966216210631
Pubmed

Glycogen synthase kinase 3β ubiquitination by TRAF6 regulates TLR3-mediated pro-inflammatory cytokine production.

TRAF6 TLR3

1.27e-04966225828701
Pubmed

Helios transcription factor expression depends on Gsx2 and Dlx1&2 function in developing striatal matrix neurons.

IKZF2 IKZF1

1.27e-04966222142223
Pubmed

Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development.

IKZF1 IL7R

1.27e-04966219734904
Pubmed

Myh7b/miR-499 gene expression is transcriptionally regulated by MRFs and Eos.

IKZF2 IKZF1

1.27e-04966222638570
Pubmed

Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta.

TRAF6 TLR3

1.27e-04966214982987
Pubmed

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4.

TRAF6 TLR3

1.58e-041066211923871
Pubmed

Both the pre-BCR and the IL-7Ralpha are essential for expansion at the pre-BII cell stage in vivo.

CR2 IL7R

1.58e-041066215909309
Pubmed

Biological, clinical and population relevance of 95 loci for blood lipids.

RAF1 DOCK7 FADS2 DOCK6

1.75e-0414666420686565
Pubmed

Multiple newly identified loci associated with prostate cancer susceptibility.

NUDT11 NUDT10

1.93e-041166218264097
Pubmed

The tyrosine kinase Syk differentially regulates Toll-like receptor signaling downstream of the adaptor molecules TRAF6 and TRAF3.

TRAF6 TLR3

1.93e-041166223962979
Pubmed

Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity.

TRAF6 IL7R

1.93e-041166219822644
Pubmed

pp60(v-src) induction of cyclin D1 requires collaborative interactions between the extracellular signal-regulated kinase, p38, and Jun kinase pathways. A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-src) signaling in breast cancer cells.

TRAF6 TLR3

1.93e-041166210066798
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

RAF1 RAPGEF6 LNX2 DOCK7 INPP5F DOCK6

2.04e-0444666624255178
Pubmed

Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.

PPIG EIF2S2 MYO18A SIL1 PCNT

2.12e-0428566532838362
Pubmed

Polymorphisms in interleukin-1 receptor-associated kinase 4 are associated with total serum IgE.

TRAF6 TLR3

2.31e-041266219254290
Pubmed

Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15.

RAF1 TRAF6 LNX2

2.39e-046366323105109
Pubmed

An ATM/TRIM37/NEMO Axis Counteracts Genotoxicity by Activating Nuclear-to-Cytoplasmic NF-κB Signaling.

TRAF6 DOCK7

2.73e-041366230254148
Pubmed

Ikaros confers early temporal competence to mouse retinal progenitor cells.

IKZF2 IKZF1

2.73e-041366218940586
Pubmed

--LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation.

TRAF6 TLR3

2.73e-041366227810922
Pubmed

Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury.

TRAF6 TLR3

2.73e-041366218423196
Pubmed

A molecular dissection of the repression circuitry of Ikaros.

IKZF2 IKZF1

3.18e-041466212015313
Pubmed

Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium.

RPUSD4 USP3

3.18e-041466220445134
Pubmed

E3 ubiquitin ligase CHIP facilitates Toll-like receptor signaling by recruiting and polyubiquitinating Src and atypical PKC{zeta}.

TRAF6 TLR3

3.18e-041466221911421
Pubmed

Validation of genome-wide prostate cancer associations in men of African descent.

NUDT11 NUDT10

3.67e-041566221071540
Pubmed

C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.

RUFY2 ZFYVE9 WFS1 SCYL3 FADS2 DOCK6

3.92e-0450466634432599
Pubmed

Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.

IKZF1 DDC

4.18e-041666222076464
Pubmed

Role of TNF ligand and receptor family in the lymphoid organogenesis defined by gene targeting.

IKZF1 IL7R

4.18e-041666210687308
Pubmed

Nebulette knockout mice have normal cardiac function, but show Z-line widening and up-regulation of cardiac stress markers.

LDB3 MYPN

4.18e-041666225987543
Pubmed

PU.1 regulates expression of the interleukin-7 receptor in lymphoid progenitors.

IKZF1 IL7R

4.74e-041766211869689
Pubmed

Serial backcross mapping of multiple loci associated with resistance to Leishmania major in mice.

IKZF1 IL7R

4.74e-04176629175833
Pubmed

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.

NAA25 IL7R

4.74e-041766217554260
Pubmed

Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR .

TRAF6 TLR3

4.74e-041766212609980
Pubmed

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

RAF1 LDB3 WFS1 IKZF1 DDC ZBTB24 SIL1

5.11e-0474266726871637
Pubmed

A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse.

RUFY2 RAPGEF6 MCF2L

5.77e-048566323055939
Pubmed

Ikaros promotes early-born neuronal fates in the cerebral cortex.

IKZF2 IKZF1

5.94e-041966223382203
Pubmed

Lymph sacs are not required for the initiation of lymph node formation.

CR2 IL7R

5.94e-041966219060331
Pubmed

Animal Models of Congenital Cardiomyopathies Associated With Mutations in Z-Line Proteins.

LDB3 MYPN

5.94e-041966227171814
Pubmed

The LIM homeobox gene Isl1 is required for the correct development of the striatonigral pathway in the mouse.

IKZF2 IKZF1

6.59e-042066224082127
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

RAF1 TLR3 MYO18A DOCK7

6.70e-0420866433230847
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

RAPGEF6 MYPN DOCK7 WIPI2

6.82e-0420966436779422
Pubmed

Mesenchymal cells are required for functional development of thymic epithelial cells.

IKZF1 IL7R

7.28e-042166217625108
Pubmed

Neurog2 and Ascl1 together regulate a postmitotic derepression circuit to govern laminar fate specification in the murine neocortex.

FEZF2 IKZF1

7.28e-042166228584103
Pubmed

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.

RUFY2 DOCK5 RAF1 SYTL4 SCYL3 DOCK7

7.39e-0456966630639242
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

RAF1 RAPGEF6 MYPN SCYL3 EIF2S2 DOCK7 GRB10 DOCK6

7.61e-04103866826673895
Pubmed

USP37 is a SNAI1 deubiquitinase.

JOSD1 USP3

9.53e-042466231911859
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

RAF1 RAPGEF6 DOCK7 INPP5F PCNT

1.20e-0341866534709266
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

DOCK5 RAF1 STK36 RAPGEF6 PCNT

1.36e-0343066535044719
Pubmed

Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population.

DOCK7 FADS2

1.39e-032966220972250
Cytoband7p12.2

GRB10 DDC

4.25e-0576627p12.2
CytobandEnsembl 112 genes in cytogenetic band chr7p12

GRB10 IKZF1 DDC

1.06e-0463663chr7p12
Cytoband8p21.2

DOCK5 ADAMDEC1

5.98e-04256628p21.2
Cytoband19q13.31

ZNF230 ZNF284

8.06e-042966219q13.31
Cytoband10q21.3

RUFY2 MYPN

1.11e-033466210q21.3
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

IKZF2 ZNF684 FEZF2 ZNF549 ZNF70 IKZF1 ZNF721 ZNF223 ZNF230 ZBTB24 ZNF284

3.25e-06718501128
GeneFamilyNudix hydrolase family

NUDT11 NUDT4 NUDT10

3.87e-0524503667
GeneFamilyPDZ domain containing

LDB3 RAPGEF6 LNX2 MYO18A

8.19e-041525041220
GeneFamilyZinc fingers FYVE-type|Pleckstrin homology domain containing|Rho guanine nucleotide exchange factors

RUFY2 ZFYVE9

3.31e-033150281
CoexpressionGSE36476_CTRL_VS_TSST_ACT_16H_MEMORY_CD4_TCELL_OLD_UP

LDB3 TLR3 JOSD1 MCF2L CR2 USP3

1.04e-05197666M5295
CoexpressionGSE36476_CTRL_VS_TSST_ACT_40H_MEMORY_CD4_TCELL_OLD_UP

LDB3 TLR3 JOSD1 MCF2L CR2 USP3

1.07e-05198666M5299
ToppCell368C-Lymphocytic-NK_cells-NK_cell_E|368C / Donor, Lineage, Cell class and subclass (all cells)

TRAF6 LNX2 ZNF230 CCDC171 IL7R

5.23e-061696650d96c0b4fd26fbc0bf44ff7bed2936eebcc55b74
ToppCellAdult-Endothelial-endothelial_cell_of_bronchial_vessel-D175|Adult / Lineage, Cell type, age group and donor

SULF2 MYO18A GRB10 ZNF230 MCF2L

6.55e-06177665c9f269765c7d5d29caab75910e51645606ed562e
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Neuroepithelial-Proteoglycan-expressing_cell|GW19 / Sample Type, Dataset, Time_group, and Cell type.

SYTL4 TLR3 DNAH2 MYO1B DOCK6

1.18e-05200665aafe594c88710f8c53d59667cdac5035e08f5511
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Neuroepithelial|GW19 / Sample Type, Dataset, Time_group, and Cell type.

SYTL4 TLR3 DNAH2 MYO1B DOCK6

1.18e-05200665a6f0f5f644b7262878b0b9d4d90ee407c4124dd9
Drugdiadenosine 5',5''''-P1,P6-hexaphosphate

NUDT11 NUDT10

8.28e-062662ctd:C070070
Drugadenosine 5'-tetraphosphate

NUDT11 NUDT10

8.28e-062662ctd:C017991
Drugadenosine 5'-pentaphosphate

NUDT11 NUDT10

8.28e-062662ctd:C048567
Drug2bxt

STK36 CR2 NDUFB7

2.18e-0519663CID011363491
DrugST021200; Up 200; 10uM; MCF7; HT_HG-U133A

LDB3 TRAF6 FADS2 IKZF1 ZNF223 WIPI2

2.36e-051986667488_UP
DiseaseHbA1c measurement

RUFY2 RAF1 NAA25 WFS1 MYPN NPRL3 FADS2 RNASE12 MCF2L CR2

2.12e-066756510EFO_0004541
Diseaselevel of Phosphatidylinositol (18:1_18:1) in blood serum

DOCK7 FADS2 DOCK6

2.87e-0613653OBA_2045159
Diseaselipoprotein measurement

NAA25 SULF2 DOCK7 FADS2 DOCK6

3.61e-06105655EFO_0004732
Diseaselevel of Phosphatidylinositol (18:0_18:1) in blood serum

DOCK7 FADS2 DOCK6

8.13e-0618653OBA_2045155
Diseaselevel of Phosphatidylinositol (18:0_18:2) in blood serum

DOCK7 FADS2 DOCK6

1.32e-0521653OBA_2045156
Diseasephospholipid measurement

NAA25 SULF2 DOCK7 FADS2 DOCK6

1.47e-05140655EFO_0004639
Diseasetype 1 diabetes mellitus

NAA25 DNAH2 GRB10 FADS2 IKZF1 IL7R

1.58e-05242656MONDO_0005147
Diseaselevel of Phosphatidylinositol (18:0_20:4) in blood serum

DOCK7 FADS2 DOCK6

1.75e-0523653OBA_2045158
Diseaselevel of Phosphatidylcholine (18:2_18:2) in blood serum

DOCK7 FADS2

7.13e-056652OBA_2045106
Diseaselevel of Phosphatidylinositol (18:1_18:2) in blood serum

DOCK7 FADS2

7.13e-056652OBA_2045160
Disease1-stearoyl-2-linoleoyl-GPC (18:0/18:2) measurement

DOCK7 FADS2

7.13e-056652EFO_0800404
Diseaselevel of Phosphatidylcholine (16:0_18:0) in blood serum

DOCK7 FADS2

7.13e-056652OBA_2045069
Disease1-palmitoyl-2-linoleoyl-GPI (16:0/18:2) measurement

DOCK7 FADS2

9.96e-057652EFO_0800609
DiseaseFamilial dilated cardiomyopathy

RAF1 LDB3 MYPN

1.27e-0444653C0340427
Disease1-palmitoyl-2-linoleoyl-GPC (16:0/18:2) measurement

DOCK7 FADS2

1.33e-048652EFO_0800610
DiseaseAtaxias, Hereditary

WFS1 SIL1

1.33e-048652C0004138
Disease1-palmitoyl-2-stearoyl-GPC (16:0/18:0) measurement

DOCK7 FADS2

1.33e-048652EFO_0800396
Diseaselevel of Phosphatidylinositol (16:0_18:2) in blood serum

DOCK7 FADS2

1.33e-048652OBA_2045153
Diseaselevel of Phosphatidylcholine (18:1_18:1) in blood serum

DOCK7 FADS2

1.33e-048652OBA_2045099
Disease1-palmitoyl-2-oleoyl-GPI (16:0/18:1) measurement

DOCK7 FADS2

1.70e-049652EFO_0800439
Disease1-palmitoyl-2-arachidonoyl-GPI (16:0/20:4) measurement

DOCK7 FADS2

1.70e-049652EFO_0800412
Diseaseinsulin response measurement

GRB10 IKZF1

1.70e-049652EFO_0008473
Diseasebasophil count, eosinophil count

IKZF2 GRB10 FADS2 IKZF1 IL7R

1.93e-04241655EFO_0004842, EFO_0005090
Disease1-stearoyl-2-oleoyl-GPI (18:0/18:1) measurement

DOCK7 FADS2

2.13e-0410652EFO_0800469
Diseaseoleoyl-linoleoyl-glycerol (18:1/18:2) [2] measurement

DOCK7 FADS2

2.13e-0410652EFO_0800333
Diseaselevel of Phosphatidylcholine (16:0_20:3) in blood serum

DOCK7 FADS2

2.13e-0410652OBA_2045075
DiseaseImmunoglobulin Deficiency, Late-Onset

IKZF1 CR2

2.59e-0411652C2936665
DiseaseAcquired Hypogammaglobulinemia

IKZF1 CR2

2.59e-0411652C2936664
Diseaselevel of Phosphatidylinositol (16:0_18:1) in blood serum

DOCK7 FADS2

3.11e-0412652OBA_2045152
Diseaselevel of Phosphatidylinositol (18:0_20:3) in blood serum

DOCK7 FADS2

3.11e-0412652OBA_2045157
Diseasepyruvate measurement

PPIG ZNF804B MYO18A NPRL3 IKZF1

3.15e-04268655EFO_0010117
DiseasePrecursor Cell Lymphoblastic Leukemia Lymphoma

IKZF2 IKZF1 IL7R

3.35e-0461653C1961102
DiseaseCommon variable immunodeficiency

IKZF1 CR2

3.67e-0413652cv:C0009447
Diseasefatty acid measurement, fetal genotype effect measurement, breast milk measurement

ZNF804B FADS2

3.67e-0413652EFO_0005110, EFO_0007959, EFO_0009092
Disease1-stearoyl-2-linoleoyl-GPI (18:0/18:2) measurement

DOCK7 FADS2

3.67e-0413652EFO_0800413
Diseasehypothyroidism

NAA25 ZNF804B TLR3 FADS2 IL7R

4.11e-04284655EFO_0004705
Diseaseacute lymphoblastic leukemia

IKZF1 ZNF230 DDC

4.23e-0466653EFO_0000220
Disease1-stearoyl-2-dihomo-linolenoyl-GPI (18:0/20:3n3 or 6) measurement

DOCK7 FADS2

4.27e-0414652EFO_0022085
Diseaselevel of Phosphatidylcholine (18:1_18:2) in blood serum

DOCK7 FADS2

4.27e-0414652OBA_2045100
Diseasefatty acid measurement, breast milk measurement, parental genotype effect measurement

ZNF804B FADS2

4.27e-0414652EFO_0005110, EFO_0005939, EFO_0009092
Diseasefatty acid measurement, linoleic acid measurement

NAA25 FADS2 CCDC171

4.62e-0468653EFO_0005110, EFO_0006807
DiseaseCommon Variable Immunodeficiency

IKZF1 CR2

4.93e-0415652C0009447
Diseasehigh density lipoprotein particle size measurement

SULF2 FADS2 RNASE12 DOCK6

5.48e-04170654EFO_0008592
Diseasefree cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement

SULF2 DOCK7 NPRL3 FADS2 DOCK6

5.51e-04303655EFO_0004612, EFO_0020945
Disease1-stearoyl-2-arachidonoyl-GPI (18:0/20:4) measurement

DOCK7 FADS2

5.62e-0416652EFO_0800184
Diseaselevel of Phosphatidylcholine (18:0_18:2) in blood serum

DOCK7 FADS2

5.62e-0416652OBA_2045090
Diseasephospholipids in large HDL measurement

SULF2 FADS2 DOCK6

5.68e-0473653EFO_0022190
Diseasetotal lipids in large HDL

SULF2 FADS2 DOCK6

5.91e-0474653EFO_0022189
Diseasecholesteryl ester measurement, high density lipoprotein cholesterol measurement

SULF2 DOCK7 FADS2 RNASE12 DOCK6

6.29e-04312655EFO_0004612, EFO_0010351
Diseasefree cholesterol measurement, high density lipoprotein cholesterol measurement

SULF2 DOCK7 FADS2 RNASE12 DOCK6

6.57e-04315655EFO_0004612, EFO_0008591
Diseasetotal cholesterol measurement, high density lipoprotein cholesterol measurement

SULF2 DOCK7 FADS2 RNASE12 DOCK6

6.57e-04315655EFO_0004574, EFO_0004612
Diseasephosphatidylcholine 36:4 measurement

FADS2 SIL1

7.15e-0418652EFO_0010382
Diseaselevel of Phosphatidylcholine (15:0_18:2) in blood serum

DOCK7 FADS2

7.15e-0418652OBA_2045065
Diseasefree cholesterol in large HDL measurement

SULF2 FADS2 DOCK6

7.16e-0479653EFO_0022157
Diseaselipid measurement, high density lipoprotein cholesterol measurement

SULF2 DOCK7 FADS2 RNASE12 DOCK6

8.10e-04330655EFO_0004529, EFO_0004612
Diseaselevel of Phosphatidylcholine (16:0_18:2) in blood serum

DOCK7 FADS2

8.85e-0420652OBA_2045071
Diseasesystemic scleroderma

IKZF2 GRB10 CR2

8.86e-0485653EFO_0000717
Diseasegestational age, birth measurement

OXR1 FADS2

9.77e-0421652EFO_0005112, EFO_0006921
Diseasephosphatidylcholine 34:3 measurement

FADS2 MYO1B

1.07e-0322652EFO_0010377
DiseaseOvarian Serous Adenocarcinoma

RAF1 STK36

1.17e-0323652C1335177
Diseasephosphatidylinositol measurement

DOCK7 FADS2 DOCK6

1.22e-0395653EFO_0010230
Diseasetriacylglycerol 56:5 measurement

DOCK5 FADS2

1.50e-0326652EFO_0010432
Disease3-methoxytyrosine measurement

GRB10 DDC

1.62e-0327652EFO_0021009
Diseasecorpus callosum mid-anterior volume measurement

GRB10 WDR72

1.62e-0327652EFO_0010297
Diseaseupper respiratory tract disorder

IKZF1 IL7R

1.74e-0328652MONDO_0004867
Diseasemean platelet volume

DOCK5 LNX2 SYTL4 DOCK7 FADS2 IKZF1 MCF2L WDR49

1.75e-031020658EFO_0004584
Diseasetestosterone measurement

DOCK5 RAF1 SYTL4 MYPN GDF6 DNAH2 RNASE12 USP3 WDR72

1.85e-031275659EFO_0004908
Diseasereticulocyte count

DOCK5 NUDT4 OXR1 NPRL3 MYO1B IKZF1 USP3 WIPI2

2.04e-031045658EFO_0007986
Diseasecholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement

DOCK7 FADS2 RNASE12 DOCK6

2.05e-03243654EFO_0004612, EFO_0020944
Diseaseantihyperlipidemic drug use measurement

DOCK7 FADS2 WDR72

2.11e-03115653EFO_0803367
Diseaseaortic stenosis

FADS2 DOCK6

2.13e-0331652EFO_0000266
Diseasetriacylglycerol 54:3 measurement

MYPN FADS2

2.13e-0331652EFO_0010421
Diseasecholesterol to total lipids in very large HDL percentage

DOCK7 DOCK6

2.13e-0331652EFO_0022243
Diseasereticulocyte measurement

DOCK5 NUDT4 OXR1 NPRL3 MYO1B IKZF1 USP3 WIPI2

2.13e-031053658EFO_0010700

Protein segments in the cluster

PeptideGeneStartEntry
LHTRLRPHCKDFLEK

CTDP1

221

Q9Y5B0
DKHKFPKHQKEQLRC

CCDC171

846

Q6TFL3
KKIHLVPCHLRDKFV

DDC

431

P20711
CHKPVHAEYLEKLKL

NUDT10

131

Q8NFP7
CAVFRLLHEHKGKKA

RAF1

96

P04049
LHKIAPLVKSLCAKH

FADS2

396

O95864
SKKDRPLCKKHAHTI

LDB3

711

O75112
KDFCPLDRKRLHFKL

LNX2

81

Q8N448
CHKPVHAEYLEKLKL

NUDT4

131

Q9NZJ9
IKKSKLHFVHCFLPV

MYO18A

1036

Q92614
FHHILPKCKLARDLK

NPRL3

191

Q12980
LPDHKKTLEHLCKKP

IL7R

276

P16871
KFLKHHLRGKNCELL

JOSD1

171

Q15040
CHKPVHAEYLEKLKL

NUDT11

131

Q96G61
LRHIKLHSGEKPFKC

IKZF1

161

Q13422
RIHHFLCDIKPLLKL

OR12D2

171

P58182
LRHIKLHSGEKPFKC

IKZF2

156

Q9UKS7
CKLLHRQPKHLLAFL

EIF2S2

226

P20042
LEKLLKHHLQKGCSP

PCNT

3076

O95613
HHLIRLLKCKRDSFP

NDUFB7

61

P17568
LGHFEKPLFLELCKH

PNPLA7

146

Q6ZV29
KPLHYKSCLFHRVVK

PPIG

56

Q13427
NKAAKHLKTLRHPCL

SCYL3

51

Q8IZE3
LLKEKQRHRLHKFLC

OXR1

546

Q8N573
RLDFLAKHILHCKAK

FJX1

416

Q86VR8
IWFKKIPLCKVIHCH

CR2

706

P20023
LLEKLLLEHCRKHKY

DOCK5

1171

Q9H7D0
PKLFRHHNKLRLCFK

DOCK6

1961

Q96HP0
DPKLFRHHNKLRLCF

DOCK7

2051

Q96N67
HLFLHEKAVLFCKKR

MCF2L

861

O15068
LNKGVLPCKLKHHCI

GRB10

576

Q13322
NLKGHHVRLCKPCKL

GPR15L

51

Q6UWK7
VFCHLPDILTKRKLH

DNAH2

906

Q9P225
TCKKEHVFIHERPRK

RNASE12

61

Q5GAN4
LCKKHHFGINKPEKI

INPP5F

106

Q9Y2H2
FCRNFDLKKHVRKLH

FEZF2

426

Q8TBJ5
HGKKSRLRCSKKPLH

GDF6

346

Q6KF10
HKAEPLHLCHRLDKE

RPUSD4

141

Q96CM3
DKKLDHCLPLHGKIS

SYTL4

471

Q96C24
IKHFIKIALHCRECK

RAPGEF6

931

Q8TEU7
EHCLKHGLKVRKSFL

RUFY2

51

Q8WXA3
KKKVLFALCSLLRHF

SIL1

286

Q9H173
VSLKAPRKLKVCHFK

WIPI2

91

Q9Y4P8
PASAKHCRKLIHLLR

STK36

1296

Q9NRP7
LHEIVCPKKLHILHK

ADAMDEC1

41

O15204
CPKKLHILHKREIKN

ADAMDEC1

46

O15204
ECGKAFIKKSHLLRH

ZNF684

331

Q5T5D7
KKKHTLLCPDFARRG

ZC3H3

771

Q8IXZ2
VITHHLLKDPLCKRF

TLR3

816

O15455
LLKDPLCKRFKVHHA

TLR3

821

O15455
ISRFKKHKLIPCSPH

ZNF804B

631

A4D1E1
ECGKAFIHKKRLLEH

ZNF549

421

Q6P9A3
LNHKRLHCRKKPFKC

ZNF223

416

Q9UK11
KFHINIHILKDCPRR

TRAF6

171

Q9Y4K3
KHKRIHTGEKPFKCL

ZNF721

786

Q8TF20
PKEILHHERKAKQLC

WDR49

671

Q8IV35
GKSCLLHARKHLFPV

WDR72

546

Q3MJ13
AKRRHCILHTGKKPF

ZBTB24

476

O43167
QKLPKVLCLHLKRFH

USP3

401

Q9Y6I4
RKIHTLKKPHECDLC

ZNF70

271

Q9UC06
SILNHKKLHCRKKPF

ZNF230

406

Q9UIE0
HLKKKRPEECDCHKI

SULF2

651

Q8IWU5
AFLLKHHCVRKPSDL

XRRA1

91

Q6P2D8
KAFCLALCPHLKLLK

ZFYVE9

1341

O95405
LRHKRLHTGEKPFKC

ZNF284

471

Q2VY69
RLKLLAKHPCHIKKF

WFS1

756

O76024
HKELKRIFHLWRCKK

MYO1B

911

O43795
HKDLHCAKVLKAIGL

NAA25

41

Q14CX7
KCIAPIFDKRLKHFR

MYPN

941

Q86TC9