Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	[heparan sulfate]-glucosamine N-sulfotransferase activity	NDST3 NDST1 NDST4	7.05e-08	4	53	3	GO:0015016
GeneOntologyMolecularFunction	N-acetylglucosamine deacetylase activity	NDST3 NDST1 NDST4	7.05e-08	4	53	3	GO:0050119
GeneOntologyMolecularFunction	deacetylase activity	NDST3 HDAC3 NDST1 NDST4	3.77e-06	40	53	4	GO:0019213
GeneOntologyMolecularFunction	heparan sulfate sulfotransferase activity	NDST3 NDST1 NDST4	7.85e-06	15	53	3	GO:0034483
GeneOntologyMolecularFunction	heparan sulfate N-deacetylase activity	NDST3 NDST1	2.07e-05	3	53	2	GO:0102140
GeneOntologyMolecularFunction	beta-adrenergic receptor kinase activity	GRK2 GRK3	4.13e-05	4	53	2	GO:0047696
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	NDST3 HDAC3 NDST1 DPYSL3 NDST4	4.22e-05	146	53	5	GO:0016810
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	NDST3 HDAC3 NDST1 NDST4	6.33e-05	81	53	4	GO:0016811
GeneOntologyMolecularFunction	G protein-coupled receptor kinase activity	GRK2 GRK3	1.44e-04	7	53	2	GO:0004703
GeneOntologyMolecularFunction	sulfotransferase activity	NDST3 NDST1 NDST4	4.20e-04	55	53	3	GO:0008146
GeneOntologyMolecularFunction	carboxylic ester hydrolase activity	NDST3 NDST1 ABHD2 LARS2	7.98e-04	157	53	4	GO:0052689
GeneOntologyMolecularFunction	transferase activity, transferring sulphur-containing groups	NDST3 NDST1 NDST4	1.00e-03	74	53	3	GO:0016782
GeneOntologyBiologicalProcess	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	NDST3 NDST1 NDST4	8.89e-07	8	53	3	GO:0015014
GeneOntologyBiologicalProcess	heparin biosynthetic process	NDST3 NDST1 NDST4	2.61e-06	11	53	3	GO:0030210
GeneOntologyBiologicalProcess	inositol phosphate metabolic process	GRK3 INPP5A SCP2 PLCG1	9.60e-06	52	53	4	GO:0043647
GeneOntologyBiologicalProcess	heparin metabolic process	NDST3 NDST1 NDST4	1.06e-05	17	53	3	GO:0030202
GeneOntologyBiologicalProcess	heparan sulfate proteoglycan biosynthetic process	NDST3 NDST1 NDST4	9.89e-05	35	53	3	GO:0015012
GeneOntologyCellularComponent	microbody lumen	CRYM AGXT SCP2	3.68e-04	55	53	3	GO:0031907
GeneOntologyCellularComponent	peroxisomal matrix	CRYM AGXT SCP2	3.68e-04	55	53	3	GO:0005782
GeneOntologyCellularComponent	cytolytic granule	GZMH GZMB	5.63e-04	14	53	2	GO:0044194
GeneOntologyCellularComponent	dendritic shaft	GRK2 GRK3 NLGN1	8.79e-04	74	53	3	GO:0043198
Domain	HSNSD	NDST3 NDST1 NDST4	7.66e-08	4	51	3	PF12062
Domain	Heparan_SO4_deacetylase	NDST3 NDST1 NDST4	7.66e-08	4	51	3	IPR021930
Domain	PYR_CT	PC HMGCLL1	2.19e-05	3	51	2	IPR000891
Domain	HMGL-like	PC HMGCLL1	2.19e-05	3	51	2	PF00682
Domain	PYR_CT	PC HMGCLL1	2.19e-05	3	51	2	PS50991
Domain	Sulfotransferase_dom	NDST3 NDST1 NDST4	1.29e-04	36	51	3	IPR000863
Domain	Sulfotransfer_1	NDST3 NDST1 NDST4	1.29e-04	36	51	3	PF00685
Domain	GPCR_kinase	GRK2 GRK3	1.52e-04	7	51	2	IPR000239
Domain	AGC-kinase_C	GRK2 GRK3 PRKCE	4.80e-04	56	51	3	IPR000961
Domain	AGC_KINASE_CTER	GRK2 GRK3 PRKCE	4.80e-04	56	51	3	PS51285
Domain	S_TK_X	GRK2 GRK3 PRKCE	4.80e-04	56	51	3	SM00133
Domain	PH_dom-like	GRK2 GRK3 NBEAL1 ANKS1B SHC4 PLCG1	1.03e-03	426	51	6	IPR011993
Domain	TIMP-like_OB-fold	NTN4 C17orf58	2.28e-03	26	51	2	IPR008993
Domain	PID	ANKS1B SHC4	2.64e-03	28	51	2	PF00640
Domain	PID	ANKS1B SHC4	3.44e-03	32	51	2	PS01179
Domain	RGS	GRK2 GRK3	4.11e-03	35	51	2	PF00615
Domain	RGS	GRK2 GRK3	4.11e-03	35	51	2	SM00315
Domain	-	GRK2 GRK3 ANKS1B SHC4 PLCG1	4.18e-03	391	51	5	2.30.29.30
Domain	RGS	GRK2 GRK3	4.34e-03	36	51	2	PS50132
Domain	RGS	GRK2 GRK3	5.08e-03	39	51	2	IPR016137
Domain	PTB	ANKS1B SHC4	5.34e-03	40	51	2	SM00462
Domain	CYSTEINE_SWITCH	ADAMTS15 MMP1	5.60e-03	41	51	2	PS00546
Domain	PTB/PI_dom	ANKS1B SHC4	5.60e-03	41	51	2	IPR006020
Domain	-	PC HMGCLL1	5.87e-03	42	51	2	3.20.20.70
Domain	Pept_M10_metallopeptidase	ADAMTS15 MMP1	6.15e-03	43	51	2	IPR001818
Domain	Aldolase_TIM	PC HMGCLL1	6.43e-03	44	51	2	IPR013785
Domain	TF_fork_head_CS_2	FOXB2 FOXA3	7.01e-03	46	51	2	IPR030456
Domain	TF_fork_head_CS_1	FOXB2 FOXA3	7.31e-03	47	51	2	IPR018122
Domain	FH	FOXB2 FOXA3	7.92e-03	49	51	2	SM00339
Domain	FORK_HEAD_1	FOXB2 FOXA3	7.92e-03	49	51	2	PS00657
Domain	FORK_HEAD_2	FOXB2 FOXA3	7.92e-03	49	51	2	PS00658
Domain	Fork_head_dom	FOXB2 FOXA3	7.92e-03	49	51	2	IPR001766
Domain	FORK_HEAD_3	FOXB2 FOXA3	7.92e-03	49	51	2	PS50039
Domain	Forkhead	FOXB2 FOXA3	7.92e-03	49	51	2	PF00250
Pathway	KEGG_MEDICUS_REFERENCE_HEPARAN_SULFATE_BIOSYNTHESIS	NDST3 NDST1 NDST4	4.60e-06	11	44	3	M47921
Pathway	KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE	NDST3 NDST1 NDST4	7.02e-05	26	44	3	M7330
Pathway	REACTOME_HS_GAG_BIOSYNTHESIS	NDST3 NDST1 NDST4	9.80e-05	29	44	3	MM14802
Pathway	REACTOME_HS_GAG_BIOSYNTHESIS	NDST3 NDST1 NDST4	1.20e-04	31	44	3	M685
Pathway	WP_GLYCOSAMINOGLYCAN_SYNTHESIS_IN_FIBROBLASTS	NDST3 NDST1 NDST4	2.78e-04	41	44	3	M48095
Pathway	REACTOME_DAG_AND_IP3_SIGNALING	GRK2 PRKCE PLCG1	2.78e-04	41	44	3	M512
Pathway	BIOCARTA_DNAFRAGMENT_PATHWAY	GZMH GZMB	5.14e-04	11	44	2	MM1349
Pathway	WP_ALANINE_AND_ASPARTATE_METABOLISM	AGXT PC	6.16e-04	12	44	2	M39331
Pathway	REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM	NDST3 NDST1 NDST4	6.30e-04	54	44	3	MM14633
Pathway	PID_TXA2PATHWAY	GRK2 GRK3 PRKCE	7.01e-04	56	44	3	M99
Pathway	BIOCARTA_D4GDI_PATHWAY	GZMH GZMB	7.27e-04	13	44	2	MM1380
Pathway	REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM	NDST3 NDST1 NDST4	7.38e-04	57	44	3	M692
Pathway	BIOCARTA_SET_PATHWAY	GZMH GZMB	8.46e-04	14	44	2	MM1403
Pubmed	Lowered expression of heparan sulfate/heparin biosynthesis enzyme N-deacetylase/n-sulfotransferase 1 results in increased sulfation of mast cell heparin.	NDST3 NDST1 NDST4	1.41e-08	4	54	3	22049073
Pubmed	Regulated translation of heparan sulfate N-acetylglucosamine N-deacetylase/n-sulfotransferase isozymes by structured 5'-untranslated regions and internal ribosome entry sites.	NDST3 NDST1 NDST4	1.41e-08	4	54	3	12070138
Pubmed	Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4.	NDST3 NDST1 NDST4	3.53e-08	5	54	3	11087757
Pubmed	FGF signaling sustains the odontogenic fate of dental mesenchyme by suppressing β-catenin signaling.	NDST3 NDST1 NDST4	1.97e-07	8	54	3	24067353
Pubmed	Developmental and regional expression of heparan sulfate sulfotransferase genes in the mouse brain.	NDST3 NDST1 NDST4	5.79e-07	11	54	3	15944372
Pubmed	Variant heparan sulfates synthesized in developing mouse brain differentially regulate FGF signaling.	NDST3 NDST1 NDST4	7.71e-07	12	54	3	12460940
Pubmed	Cloning of a gene that encodes a new member of the human cytotoxic cell protease family.	GZMH GZMB	2.37e-06	2	54	2	2193684
Pubmed	Rapid reuptake of granzyme B leads to emperitosis: an apoptotic cell-in-cell death of immune killer cells inside tumor cells.	GZMH GZMB	2.37e-06	2	54	2	24113190
Pubmed	Structure and expression of a cluster of human hematopoietic serine protease genes found on chromosome 14q11.2.	GZMH GZMB	2.37e-06	2	54	2	2007574
Pubmed	A cluster of hematopoietic serine protease genes is found on the same chromosomal band as the human alpha/delta T-cell receptor locus.	GZMH GZMB	2.37e-06	2	54	2	2300587
Pubmed	Maternal diesel particle exposure promotes offspring asthma through NK cell-derived granzyme B.	GZMH GZMB	2.37e-06	2	54	2	32407293
Pubmed	Structure and evolutionary origin of the human granzyme H gene.	GZMH GZMB	2.37e-06	2	54	2	2049336
Pubmed	Granzyme B mediates both direct and indirect cleavage of extracellular matrix in skin after chronic low-dose ultraviolet light irradiation.	GZMH GZMB	2.37e-06	2	54	2	25495009
Pubmed	Cloning of GRK2 cDNA from S49 murine lymphoma cells.	GRK2 GRK3	2.37e-06	2	54	2	8638670
Pubmed	Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.	GZMH GZMB	2.37e-06	2	54	2	8137431
Pubmed	Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway.	GZMH GZMB	2.37e-06	2	54	2	17179148
Pubmed	Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling.	GZMH GZMB	2.37e-06	2	54	2	33674611
Pubmed	Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection.	GZMH GZMB	2.37e-06	2	54	2	22236998
Pubmed	Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B.	GZMH GZMB	2.37e-06	2	54	2	7566124
Pubmed	Cloning of two genes that are specifically expressed in activated cytotoxic T lymphocytes.	GZMH GZMB	2.37e-06	2	54	2	3485287
Pubmed	Granzyme B-Mediated Activation-Induced Death of CD4+ T Cells Inhibits Murine Acute Graft-versus-Host Disease.	GZMH GZMB	2.37e-06	2	54	2	26392464
Pubmed	Granzyme B in injury, inflammation, and repair.	GZMH GZMB	2.37e-06	2	54	2	23099058
Pubmed	Differential cleavage of viral polypeptides by allotypic variants of granzyme B skews immunity to mouse cytomegalovirus.	GZMH GZMB	2.37e-06	2	54	2	32473350
Pubmed	A novel lineage-specific hypersensitive site is essential for position independent granzyme B expression in transgenic mice.	GZMH GZMB	2.37e-06	2	54	2	18222115
Pubmed	Granule-derived granzyme B mediates the vulnerability of human neurons to T cell-induced neurotoxicity.	GZMH GZMB	2.37e-06	2	54	2	21964027
Pubmed	Fas Ligand-mediated cytotoxicity of CD4+ T cells during chronic retrovirus infection.	GZMH GZMB	2.37e-06	2	54	2	28798348
Pubmed	Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3.	GRK2 GRK3	2.37e-06	2	54	2	10198406
Pubmed	Dissecting the roles of GRK2 and GRK3 in μ-opioid receptor internalization and β-arrestin2 recruitment using CRISPR/Cas9-edited HEK293 cells.	GRK2 GRK3	2.37e-06	2	54	2	33060647
Pubmed	The granzyme B gene is highly polymorphic in wild mice but essentially invariant in common inbred laboratory strains.	GZMH GZMB	2.37e-06	2	54	2	17661907
Pubmed	Differential expression of granzyme B and C in murine cytotoxic lymphocytes.	GZMH GZMB	2.37e-06	2	54	2	19414782
Pubmed	Granzyme B releases vascular endothelial growth factor from extracellular matrix and induces vascular permeability.	GZMH GZMB	2.37e-06	2	54	2	24791744
Pubmed	Activated mouse B cells lack expression of granzyme B.	GZMH GZMB	2.37e-06	2	54	2	22427643
Pubmed	Distinct patterns of cytolytic T-cell activation by different tumour cells revealed by Ca2+ signalling and granule mobilization.	GZMH GZMB	2.37e-06	2	54	2	27716898
Pubmed	A role for the granzyme B inhibitor serine protease inhibitor 6 in CD8+ memory cell homeostasis.	GZMH GZMB	2.37e-06	2	54	2	15356127
Pubmed	Granule-mediated killing by granzyme B and perforin requires a mannose 6-phosphate receptor and is augmented by cell surface heparan sulfate.	GZMH GZMB	2.37e-06	2	54	2	16280358
Pubmed	Granzyme B deficiency promotes osteoblastic differentiation and calcification of vascular smooth muscle cells in hypoxic pulmonary hypertension.	GZMH GZMB	2.37e-06	2	54	2	29445095
Pubmed	Granzyme B plays a critical role in cytotoxic lymphocyte-induced apoptosis.	GZMH GZMB	2.37e-06	2	54	2	7493755
Pubmed	Sepsis alters the megakaryocyte-platelet transcriptional axis resulting in granzyme B-mediated lymphotoxicity.	GZMH GZMB	2.37e-06	2	54	2	19136373
Pubmed	Copy number loss in granzyme genes confers resistance to immune checkpoint inhibitor in nasopharyngeal carcinoma.	GZMH GZMB	2.37e-06	2	54	2	33737344
Pubmed	Role of Bid-induced mitochondrial outer membrane permeabilization in granzyme B-induced apoptosis.	GZMH GZMB	2.37e-06	2	54	2	16405654
Pubmed	G-protein coupled receptor kinase 2 and 3 expression in human detrusor cultured smooth muscle cells.	GRK2 GRK3	2.37e-06	2	54	2	11762794
Pubmed	Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1α.	GZMH GZMB	2.37e-06	2	54	2	22017873
Pubmed	Granzyme B Disrupts Central Metabolism and Protein Synthesis in Bacteria to Promote an Immune Cell Death Program.	GZMH GZMB	2.37e-06	2	54	2	29107333
Pubmed	G protein--coupled receptor kinases.	GRK2 GRK3	2.37e-06	2	54	2	8035170
Pubmed	Granzyme B prevents aberrant IL-17 production and intestinal pathogenicity in CD4+ T cells.	GZMH GZMB	2.37e-06	2	54	2	34183776
Pubmed	Analysis of protein processing by N-terminal proteomics reveals novel species-specific substrate determinants of granzyme B orthologs.	GZMH GZMB	2.37e-06	2	54	2	18836177
Pubmed	Granzyme B Contributes to Barrier Dysfunction in Oxazolone-Induced Skin Inflammation through E-Cadherin and FLG Cleavage.	GZMH GZMB	2.37e-06	2	54	2	32504614
Pubmed	Granzyme B and the downstream granzymes C and/or F are important for cytotoxic lymphocyte functions.	GZMH GZMB	2.37e-06	2	54	2	15699143
Pubmed	Characterization of a novel, human cytotoxic lymphocyte-specific serine protease cDNA clone (CSP-C).	GZMH GZMB	2.37e-06	2	54	2	2402757
Pubmed	Granzyme B is critical for T cell receptor-induced cell death of type 2 helper T cells.	GZMH GZMB	2.37e-06	2	54	2	16901729
Pubmed	Discordant regulation of granzyme H and granzyme B expression in human lymphocytes.	GZMH GZMB	2.37e-06	2	54	2	15069086
Pubmed	Interplay between chromatin remodeling and epigenetic changes during lineage-specific commitment to granzyme B expression.	GZMH GZMB	2.37e-06	2	54	2	19915065
Pubmed	Granzyme B is dispensable in the development of diabetes in non-obese diabetic mice.	GZMH GZMB	2.37e-06	2	54	2	22792290
Pubmed	Organization of two genes encoding cytotoxic T lymphocyte-specific serine proteases CCPI and CCPII.	GZMH GZMB	2.37e-06	2	54	2	3264185
Pubmed	The herpes simplex virus type 1 latency-associated transcript can protect neuron-derived C1300 and Neuro2A cells from granzyme B-induced apoptosis and CD8 T-cell killing.	GZMH GZMB	2.37e-06	2	54	2	21177822
Pubmed	Studying the biology of cytotoxic T lymphocytes in vivo with a fluorescent granzyme B-mTFP knock-in mouse.	GZMH GZMB	2.37e-06	2	54	2	32696761
Pubmed	Visualization of granzyme B-expressing CD8 T cells during primary and secondary immune responses to Listeria monocytogenes.	GZMH GZMB	2.37e-06	2	54	2	25367158
Pubmed	Requirement of MHC class I on radioresistant cells for granzyme B expression from CD8+ T cells in murine contact hypersensitivity.	GZMH GZMB	2.37e-06	2	54	2	29428817
Pubmed	Inhibitory Effect of Zinc on Colorectal Cancer by Granzyme B Transcriptional Regulation in Cytotoxic T Cells.	GZMH GZMB	2.37e-06	2	54	2	37298408
Pubmed	Granzyme B deficiency exacerbates lung inflammation in mice after acute lung injury.	GZMH GZMB	2.37e-06	2	54	2	23642129
Pubmed	Granzyme B inhibition reduces disease severity in autoimmune blistering diseases.	GZMH GZMB	2.37e-06	2	54	2	33436591
Pubmed	Protein kinase Cepsilon may act as EGF-inducible scaffold protein for phospholipase Cgamma1.	PRKCE PLCG1	2.37e-06	2	54	2	17561374
Pubmed	Novel serine proteases encoded by two cytotoxic T lymphocyte-specific genes.	GZMH GZMB	2.37e-06	2	54	2	3518058
Pubmed	Genetic deletion of granzyme B does not confer resistance to the development of spontaneous diabetes in non-obese diabetic mice.	GZMH GZMB	2.37e-06	2	54	2	23663075
Pubmed	Heparan sulfate biosynthetic gene Ndst1 is required for FGF signaling in early lens development.	NDST3 NDST1 NDST4	3.96e-06	20	54	3	17107998
Pubmed	NDST1-dependent heparan sulfate regulates BMP signaling and internalization in lung development.	NDST3 NDST1 NDST4	5.34e-06	22	54	3	19299468
Pubmed	Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309.	GRK2 GRK3	7.09e-06	3	54	2	10754297
Pubmed	Granzyme B expression by CD8+ T cells is required for the development of experimental cerebral malaria.	GZMH GZMB	7.09e-06	3	54	2	21525386
Pubmed	Granzyme B Deficiency Protects against Angiotensin II-Induced Cardiac Fibrosis.	GZMH GZMB	7.09e-06	3	54	2	26610869
Pubmed	Granzyme B is not required for regulatory T cell-mediated suppression of graft-versus-host disease.	GZMH GZMB	7.09e-06	3	54	2	19965675
Pubmed	Secretory lysosomes of mouse mast cells store and exocytose active caspase-3 in a strictly granzyme B dependent manner.	GZMH GZMB	7.09e-06	3	54	2	24414824
Pubmed	Granzyme B degrades extracellular matrix and contributes to delayed wound closure in apolipoprotein E knockout mice.	GZMH GZMB	7.09e-06	3	54	2	23912712
Pubmed	Platelets induce apoptosis during sepsis in a contact-dependent manner that is inhibited by GPIIb/IIIa blockade.	GZMH GZMB	7.09e-06	3	54	2	22844498
Pubmed	A pro-survival role for the intracellular granzyme B inhibitor Serpinb9 in natural killer cells during poxvirus infection.	GZMH GZMB	7.09e-06	3	54	2	28722018
Pubmed	Collateral neuronal apoptosis in CNS gray matter during an oligodendrocyte-directed CD8(+) T cell attack.	GZMH GZMB	7.09e-06	3	54	2	19780193
Pubmed	The Transcription Factor Tcf1 Contributes to Normal NK Cell Development and Function by Limiting the Expression of Granzymes.	GZMH GZMB	7.09e-06	3	54	2	28723565
Pubmed	The cytotoxic T cell proteinase granzyme B does not activate interleukin-1 beta-converting enzyme.	GZMH GZMB	7.09e-06	3	54	2	7798197
Pubmed	Granzyme B-mediated death of pancreatic beta-cells requires the proapoptotic BH3-only molecule bid.	GZMH GZMB	7.09e-06	3	54	2	16873683
Pubmed	Visualization of cytolytic T cell differentiation and granule exocytosis with T cells from mice expressing active fluorescent granzyme B.	GZMH GZMB	7.09e-06	3	54	2	23840635
Pubmed	Granzyme A- and B-cluster deficiency delays acute lung injury in pneumovirus-infected mice.	GZMH GZMB	7.09e-06	3	54	2	20018616
Pubmed	Differential effects of CC chemokines on CC chemokine receptor 5 (CCR5) phosphorylation and identification of phosphorylation sites on the CCR5 carboxyl terminus.	GRK2 GRK3	7.09e-06	3	54	2	10085131
Pubmed	A critical role for granzyme B, in addition to perforin and TNFalpha, in alloreactive CTL-induced mouse pancreatic beta cell death.	GZMH GZMB	7.09e-06	3	54	2	16436955
Pubmed	Long-range disruption of gene expression by a selectable marker cassette.	GZMH GZMB	7.09e-06	3	54	2	8917549
Pubmed	Hop cleavage and function in granzyme B-induced apoptosis.	GZMH GZMB	7.09e-06	3	54	2	17005566
Pubmed	Granzymes A and B Regulate the Local Inflammatory Response during Klebsiella pneumoniae Pneumonia.	GZMH GZMB	7.09e-06	3	54	2	26894590
Pubmed	Granzyme B-mediated damage of CD8+ T cells impairs graft-versus-tumor effect.	GZMH GZMB	7.09e-06	3	54	2	23264653
Pubmed	Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy.	GZMH GZMB	7.09e-06	3	54	2	20400962
Pubmed	Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor.	GRK2 GRK3	7.09e-06	3	54	2	7761854
Pubmed	Murine myeloid derived suppressor cells possess a range of suppressive mechanisms-Granzyme B is not among them.	GZMH GZMB	7.09e-06	3	54	2	35129637
Pubmed	Processing and activation of CMH-1 by granzyme B.	GZMH GZMB	7.09e-06	3	54	2	8631895
Pubmed	Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis.	GZMH GZMB	7.09e-06	3	54	2	16606695
Pubmed	The course of Leishmania major infection in mice lacking granzyme-mediated mechanisms.	GZMH GZMB	7.09e-06	3	54	2	12182457
Pubmed	The role of intrahepatic CD3+/CD4-/CD8- double negative T (DN T) cells in enhanced acetaminophen toxicity.	GZMH GZMB	7.09e-06	3	54	2	25168425
Pubmed	The differential contribution of granzyme A and granzyme B in cytotoxic T lymphocyte-mediated apoptosis is determined by the quality of target cells.	GZMH GZMB	7.09e-06	3	54	2	12115618
Pubmed	A novel and divergent role of granzyme A and B in resistance to helminth infection.	GZMH GZMB	7.09e-06	3	54	2	21248253
Pubmed	The N-termini of GRK2 and GRK3 simulate the stimulating effects of RKIP on β-adrenoceptors.	GRK2 GRK3	7.09e-06	3	54	2	31604529
Pubmed	Autocrine DNA fragmentation of intra-epithelial lymphocytes (IELs) in mouse small intestine.	GZMH GZMB	7.09e-06	3	54	2	25750028
Pubmed	Comparative molecular model building of two serine proteinases from cytotoxic T lymphocytes.	GZMH GZMB	7.09e-06	3	54	2	3237717
Pubmed	Bcl6 controls granzyme B expression in effector CD8+ T cells.	GZMH GZMB	7.09e-06	3	54	2	17125145
Pubmed	Identification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes.	GZMH GZMB	7.09e-06	3	54	2	35210420
Interaction	NDST4 interactions	NDST3 NDST1 NDST4	8.99e-07	8	52	3	int:NDST4
GeneFamily	Sulfotransferases, membrane bound	NDST3 NDST1 NDST4	4.52e-05	37	34	3	763
GeneFamily	Forkhead boxes	FOXB2 FOXA3	2.95e-03	43	34	2	508
ToppCell	PBMC-Control-cDC_2\|Control / Compartment, Disease Groups and Clusters	ZNF462 NBEAL1 SH3D19 GZMH GZMB	1.18e-06	153	54	5	4ee37266b0054f276c7a73ab9220f681b9d74c71
ToppCell	Control-Classical_Monocyte-cMono_1\|Classical_Monocyte / Disease condition and Cell class	GRK2 NBEAL1 SH3D19 GZMH GZMB	1.56e-06	162	54	5	b44021f4750e9ff3ac7f683ef8255dd2087f2c05
ToppCell	facs-Liver-Non-hepatocytes-3m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB AGXT SCP2 PC LARS2	2.09e-06	172	54	5	feaaf8ca7983d04a59ed0a7b3fb0e6d4b3a055f2
ToppCell	facs-Liver-Non-hepatocytes-3m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB AGXT SCP2 PC LARS2	2.09e-06	172	54	5	9adfb4a65669cc536343616637058d0a4728013f
ToppCell	facs-Liver-Non-hepatocytes-3m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB AGXT SCP2 PC LARS2	2.09e-06	172	54	5	8aed9c113f27d00401c272a3684495a4bc75bd0f
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Fibcd1\|Hippocampus / BrainAtlas - Mouse McCarroll V32	NDST3 CRYM NDST4 SLITRK6	1.88e-05	130	54	4	c70fb77324916d220d842a575558a8245c276599
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	NDST1 ZNF408 GZMH GZMB	3.13e-05	148	54	4	065177aaa63c0441d312260b43ecdac78c84ad03
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	GZMH GZMB PLCG1 BBS9	3.47e-05	152	54	4	669d8f12fdb110ed72f4e5348b7b5350144a061c
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c06-TNF\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	KBTBD4 GZMH GZMB C17orf58	3.56e-05	153	54	4	0727dc70e16345645063c586d744bc4ac1710526
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|367C / Donor, Lineage, Cell class and subclass (all cells)	ZNF408 GZMH GZMB ZNF317	4.04e-05	158	54	4	c08b5e12cc2975e52965e22ec987d0d45a9a68e9
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	INPP5A ZNF408 GZMH MYO18A	4.14e-05	159	54	4	1472536eea61d4f13033efe42f128bae1614fa74
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ZNF408 GZMH GZMB ZNF317	4.67e-05	164	54	4	4ade97931ae1780af7836d988fe117a10b3e88a1
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SH3D19 GZMH GZMB PRKCE	5.13e-05	168	54	4	94cded2e953c0970bf2f3dbe0ce46bd77a5ed8c7
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GZMH GZMB NLGN1 PC	6.01e-05	175	54	4	1b35acece23712ab7e3f92d9d68266efd38b3ef5
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GZMH GZMB NLGN1 PC	6.01e-05	175	54	4	a9f88054e2c28d604c65ed785f63021aadb7f4c8
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	AGXT ANKS1B NLGN1 PC	6.28e-05	177	54	4	2f81b26be89cc2fd8eafadaf7eae3c6ad6521462
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF462 NTN4 ADAMTS15 NLGN1	7.15e-05	183	54	4	738e94b50c4c08c727d4eed0708dda08aa6891b4
ToppCell	droplet-Limb_Muscle-nan-3m-Macroglial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRYM ANKS1B SHC4 SLITRK6	7.30e-05	184	54	4	da8d6e7944eb35e6cbea2feb7cbc2894787d723f
ToppCell	droplet-Limb_Muscle-nan-21m-Macroglial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKS1B SHC4 SLITRK6 FOXA3	7.30e-05	184	54	4	9f8cd5ab5af6c35a1be25d70a125b9a3f4dd667a
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	DPYSL3 GZMH GZMB LARS2	7.45e-05	185	54	4	daea170d827226dda6750bf1838ffd82f070c4d4
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FLNB NTN4 SH3D19 HMGCLL1	8.10e-05	189	54	4	e32172ad09e93f6ac6ea2b92145b2b73003f7970
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ZNF462 NTN4 ADAMTS15 NLGN1	8.10e-05	189	54	4	904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCell	Severe-Lymphoid-NK-Treg\|Severe / Condition, Lineage, Cell class and cell subclass	KBTBD4 GZMH GZMB MYO18A	8.26e-05	190	54	4	e67803bf55a3f8e47a69ff1829c9100f870d7527
ToppCell	pdx-Tumor_cells-T8\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	NDST1 AGXT SCP2 PRKCE	8.26e-05	190	54	4	b05db0de9b6ae01dd30074453f7de44f7397631e
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB ABHD2 SLITRK6 PC	8.43e-05	191	54	4	f76f3f5c7902a3659d8cbe470f96ce57c8a6744d
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB ABHD2 SLITRK6 PC	8.60e-05	192	54	4	5b7093d5af5ae7b0e6d3a464cc56272440ecedad
ToppCell	Fetal_29-31_weeks-Mesenchymal-myofibroblast_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NDST3 ANKS1B NDST4 SLITRK6	8.60e-05	192	54	4	72881b280a415e65f87a80ca1369cbb0b722a0c4
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DPYSL3 CRYM ANKS1B SHC4	8.78e-05	193	54	4	66af80f4b51e1ce97b6fb7c630dc5f95bfa7e7d4
ToppCell	facs-Lung-nan-3m-Endothelial-endothelial_cell_of_lung\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	INPP5A PRKCE PLCG1 LARS2	8.95e-05	194	54	4	f159ef8541d75a4e98468947f231bb463bec922c
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Deep_Layer-37\|World / Primary Cells by Cluster	DPYSL3 CRYM GRK3 NLGN1	9.50e-05	197	54	4	00d756bc0231e1b3b88430214338c1059cb11106
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_airway_secretory-Secretory_Goblet\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	CRYM DTX4 SHC4 FOXA3	9.69e-05	198	54	4	5dd2aa7684c36beffa204ca4c04d0501cabac10f
ToppCell	control-Epithelial-Secretory\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	FLNB NBEAL1 DTX4 SLITRK6	9.88e-05	199	54	4	262e5b8a52c8ddb0b47048c786e8bdb7158e1b9a
ToppCell	background-Hepatocytes\|background / Sample and Cell Type and Tumor Cluster (all cells)	ABHD2 AGXT SCP2 PC	1.01e-04	200	54	4	787d35b5c2f2ad967ae14e99496a0299ac7e72fd
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DPYSL3 NDST4 SLITRK6 HMGCLL1	1.01e-04	200	54	4	fb53be20392a8309a7393774c774a1b1aec6e676
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	GZMH GZMB SCP2	1.12e-04	77	54	3	ebb1a537751739232820a60f88911877fc683855
ToppCell	Mild/Remission-B_naive-1\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	GRK2 GRK3 NLGN1	4.26e-04	121	54	3	68940a552233d255b90ce5a081339c0d9d46ab02
ToppCell	COVID_vent-Lymphocytic-T_cell-Gamma_Delta_T_cell\|COVID_vent / Disease condition, Lineage, Cell class and subclass	NTN4 ZNF555 HMGCLL1	5.49e-04	132	54	3	dbc0a332fd8f63ebdcf9716e45d7f46f26509349
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_B0\|356C / Donor, Lineage, Cell class and subclass (all cells)	GZMH GZMB SHC4	6.12e-04	137	54	3	fec21e7a25241289b18aea6a46dc2b981438ebe6
ToppCell	E18.5-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_B\|E18.5-samps / Age Group, Lineage, Cell class and subclass	NTN4 ADAMTS15 NLGN1	6.12e-04	137	54	3	b553958e7e6dcd887d860e34d3983cbb85cefaa6
ToppCell	E16.5-samps-Mesenchymal-Myofibroblast-Smooth_Muscle-like_MyoFibroblast\|E16.5-samps / Age Group, Lineage, Cell class and subclass	NTN4 ADAMTS15 NLGN1	6.51e-04	140	54	3	5623a0a68403fc00166b7d13d13e184a718d9bdd
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Bcl6\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	NDST3 CRYM NLGN1	7.07e-04	144	54	3	08005be9e3367f78ef27e125d9cce5ca53f4bd2d
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1\|368C / Donor, Lineage, Cell class and subclass (all cells)	GZMH GZMB SHC4	7.50e-04	147	54	3	743767abdb3b5ecad870b617f515b037ce280818
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell-T_gdT_c14-TRDV2\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NTN4 GZMH GZMB	7.50e-04	147	54	3	22c9605869dd2e789896cd2790ee8def2605de57
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-CD8-positive,_mature_gamma-delta_T_cell\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NTN4 GZMH GZMB	7.50e-04	147	54	3	ac272595818d25c6b84b107555b3351e912a01a7
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GZMH GZMB ALG1	7.50e-04	147	54	3	55f4b3289094a1eab6d7a6c8f214ec7b031edfa8
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_B\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	GZMH GZMB CEP57L1	7.65e-04	148	54	3	1d9fa6b2ee9feaed39c63d44e638b5c0942d947c
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	GZMH GZMB SHC4	7.65e-04	148	54	3	e7bbb5ddf44b11b8495e83863fbf1fd9f3f24472
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	GZMH GZMB MYO18A	7.65e-04	148	54	3	c240d506151fa90c59f40008c5fb31984c6f6f8f
ToppCell	facs-Aorta-Heart-3m-Epithelial\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NDST3 GZMH FOXA3	8.11e-04	151	54	3	bee48137d1f5f27a24571a59c835284651d38538
ToppCell	facs-Aorta-Heart-3m-Epithelial-epithelial_cell\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NDST3 GZMH FOXA3	8.11e-04	151	54	3	0de76acd1b204345dce7f33be2a1ed9fbe9e6da0
ToppCell	facs-Aorta-Heart-3m-Epithelial-nan\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NDST3 GZMH FOXA3	8.11e-04	151	54	3	20b9c8fb966c5d62ff909cc4a4616b109b78cdca
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	INPP5A GZMH GZMB	8.42e-04	153	54	3	433b971c98da321204e065019db4e7825c7587cd
ToppCell	356C-Lymphocytic-NK_cells-NK_cell_D2\|356C / Donor, Lineage, Cell class and subclass (all cells)	GZMH GZMB FREM3	8.42e-04	153	54	3	5fb7d92cddc816c64071465e955ed0ea3bb45316
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_B\|343B / Donor, Lineage, Cell class and subclass (all cells)	GZMH GZMB CEP57L1	8.58e-04	154	54	3	886e7cd01cb48ca3e97debeea2b1f100b09d47e6
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	GZMH GZMB SCP2	8.58e-04	154	54	3	ea5d0da5dd8ccfc19969aec35f044db77d589f54
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NDST4 PRKCE LARS2	8.74e-04	155	54	3	72a19a9ecfd13f6769c4b447d3ce01a855ec6ec7
ToppCell	droplet-Liver-nan-3m-Epithelial-Hepatocyte_(Midlobular)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB AGXT SCP2	8.74e-04	155	54	3	8742a4eef328c05ca9a88e499868e45073545094
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|356C / Donor, Lineage, Cell class and subclass (all cells)	ZNF408 GZMH GZMB	8.91e-04	156	54	3	7ccd20e3bbce6a070df45034b0bdc255f267efb1
ToppCell	368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	GZMH GZMB SHC4	8.91e-04	156	54	3	c11ca6b1b5029c15aab91273cece70a487287839
ToppCell	TCGA-Colorectal-Solid_Tissue_Normal-Rectum_normal_tissue-Rectum_normal_tissue-9\|TCGA-Colorectal / Sample_Type by Project: Shred V9	ANKS1B NLGN1 HMGCLL1	9.41e-04	159	54	3	f376bf6cd0ed374211edac3c384f3a78f0caef2a
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|356C / Donor, Lineage, Cell class and subclass (all cells)	ZNF408 GZMH MYO18A	9.41e-04	159	54	3	2fb1d2ff52920aeb48d048cf29f0cd45f944a73d
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	GZMH GZMB WDR44	9.58e-04	160	54	3	0f15f895f11dcabb73df79b26bfc4947f38435a7
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(CH25H+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DTX4 NDST4 HMGCLL1	9.58e-04	160	54	3	6215ac6123a295f3c2f033786602a57b2e2e1177
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	KBTBD4 GZMH GZMB	9.58e-04	160	54	3	8e2b51d7b42e0b6e62641efdbbc73d31561d6a3e
ToppCell	Severe-Lymphoid-NK-Proliferating_T\|Severe / Condition, Lineage, Cell class and cell subclass	GZMH GZMB MYO18A	9.58e-04	160	54	3	cb2276d9bd78508644420e9580d3c17b914224cb
ToppCell	metastatic_Brain-T/NK_cells-CD8+/CD4+_Mixed_Th\|metastatic_Brain / Location, Cell class and cell subclass	GZMH GZMB ANKS1B	9.58e-04	160	54	3	bc86c6ba1b7815ab944e1ec9da703f469373b8b1
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	GZMH GZMB WDR44	9.58e-04	160	54	3	50d4f867d021abcfeb49e6812bcfd5bb57466a31
ToppCell	367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	GZMH GZMB ADAMTS15	9.58e-04	160	54	3	955acb023ce4ccfac5073c9d693db87db3856187
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	GZMH GZMB WDR44	9.58e-04	160	54	3	7d004bfe42707605b3851cb2319126acda4d4802
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	HAUS6 SHC4 PLCG1	9.76e-04	161	54	3	5fba13f0aa5002f7eefe219e2c6a07e163f1a50d
ToppCell	390C-Endothelial_cells-Endothelial-E-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	GRK3 MYO18A PRKCE	9.93e-04	162	54	3	fbb0cc2b1434a340dc35058b77c73ea61004c252
ToppCell	URO-Lymphocyte-T_NK-CD4_CTL\|URO / Disease, Lineage and Cell Type	GZMH GZMB SHC4	9.93e-04	162	54	3	1afeeb17e263cf625a4f285203cf82f973735193
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ANKS1B NDST4 LARS2	9.93e-04	162	54	3	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	Multiple_Sclerosis-Lymphocyte-T_NK-CD4_CTL\|Multiple_Sclerosis / Disease, Lineage and Cell Type	ZNF408 GZMH GZMB	9.93e-04	162	54	3	d53de64df2511eddba79f899fc3f48b1b059923f
ToppCell	droplet-Marrow-BM-30m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SHC4 PRKCE WDR44	9.93e-04	162	54	3	75df7ff779a3b9159ba97d852da1f8df650b9ce5
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	NTN4 GZMH GZMB	9.93e-04	162	54	3	f0a92c92c3a6cf9fa11fb279a584e7f328cb7d43
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_VISp_Ctxn3_Sla\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NDST3 NDST1 CRYM	9.93e-04	162	54	3	4d13c271b4f63cf32980e5643b5d5951165fe8b5
ToppCell	390C-Endothelial_cells-Endothelial-E\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	GRK3 MYO18A PRKCE	9.93e-04	162	54	3	45be019b50e3727fc9d3fad2ff78e74e4f2d746b
ToppCell	356C-Myeloid-Dendritic-pDC\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	FLNB CRYM GZMB	1.01e-03	163	54	3	ae9c5eb19657ea94b7f2357cbc8679acd697b8fe
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_B2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	INPP5A GZMH GZMB	1.01e-03	163	54	3	6c4d4c55fc8a731acca13c1ba7287f238a9d81e0
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c06-TNF\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	NTN4 GZMH GZMB	1.03e-03	164	54	3	84a1808bc6f501218ac2a5a05eb188a07ccd3890
ToppCell	356C-Myeloid-Dendritic-pDC\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	FLNB CRYM GZMB	1.03e-03	164	54	3	fed26f4ac36a2b0722bc7b9f91659c5e0cf4d53a
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Epithelial-hepatocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB AGXT SCP2	1.05e-03	165	54	3	a508d66031c1a46b062afbee3cde1cbd0c163a03
ToppCell	Control-Control-Lymphocyte-T/NK-CD8+_Tcm\|Control / Disease, condition lineage and cell class	NBEAL1 SH3D19 ANKS1B	1.05e-03	165	54	3	c55f91c4dc70d5021b4efcc795024eb1681d2564
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3_LINC00507_PSRC1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	NDST3 CRYM FREM3	1.05e-03	165	54	3	6de69b75174731931e7e80a3488f983a7ba4defe
ToppCell	368C-Myeloid-Dendritic-cDC_activated\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	CRYM PC LARS2	1.05e-03	165	54	3	9d2bdc42c13c8c2a68889bec8612a1ce56f659fa
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Epithelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB AGXT SCP2	1.05e-03	165	54	3	dba630e205eb3725195f8861e4af5b745ccfdc74
ToppCell	facs-Liver-Liver_non-hepato/SCs_st-18m-Epithelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB AGXT SCP2	1.05e-03	165	54	3	b03c8c3110f32257e78838885b313a922af73c98
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FLNB HAUS6 KBTBD4	1.05e-03	165	54	3	62457b7b74c6eae42d91d65e7dc6df6bf8e061f7
ToppCell	droplet-Lung-LUNG-1m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB GRK3 MACROH2A1	1.07e-03	166	54	3	c215c4aede38d355d35fd26cd7ef2c19efecd0e6
ToppCell	PND01-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_prolif\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CRYM NLGN1 SLITRK6	1.07e-03	166	54	3	49103b75c3e08656c5774f56fd00d7bd53eefcfb
ToppCell	droplet-Heart-nan-24m-Mesenchymal-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABHD2 B4GALNT2 BBS9	1.08e-03	167	54	3	a35ace2c722936d2a3e1f0826e5b6ec6b1340d2b
ToppCell	Bronchial_Biopsy-Immune-Mast_cells\|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X	ZNF462 MYO18A BBS9	1.10e-03	168	54	3	45ccc0cb42d21f4853190e8e9ed9a54aefefe738
ToppCell	TCGA-Uvea-Primary_Tumor-Uveal_Melanoma-Spindle_Cell-1\|TCGA-Uvea / Sample_Type by Project: Shred V9	GRK2 AGXT AAR2	1.10e-03	168	54	3	b427746929bb40e3d1b5f1c40d302b792d6b32a5
ToppCell	Healthy_Control-Lymphoid-pDC\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	FLNB CRYM GZMB	1.12e-03	169	54	3	a4e9b8b2f0338203455ba941b8f99bf4884d26f0
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Microglia/Mac\|Myeloid_cells / Location, Cell class and cell subclass	NTN4 DPYSL3 GRK3	1.12e-03	169	54	3	dba8f5599aa21feef5b7fdfed2e3ab54748d80f7
ToppCell	TCGA-Colorectal-Solid_Tissue_Normal-Rectum_normal_tissue-Rectum_normal_tissue\|TCGA-Colorectal / Sample_Type by Project: Shred V9	ANKS1B NLGN1 HMGCLL1	1.12e-03	169	54	3	91f4b6a14708e701b2af22989004282041777491
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLNB GRK3 MACROH2A1	1.12e-03	169	54	3	735655e75511c5c41aca667909e8bb52a0ad7fc6
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Lymphocytic-NK_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GZMH GZMB BBS9	1.12e-03	169	54	3	8028622ff362d70d1002e65a74ade46ea7f1f13f
ToppCell	TCGA-Colorectal-Solid_Tissue_Normal-Rectum_normal_tissue\|TCGA-Colorectal / Sample_Type by Project: Shred V9	ANKS1B NLGN1 HMGCLL1	1.12e-03	169	54	3	41cb92b0558f0d5a3e511058efd9110258b88ee3
Drug	Trimethylcolchicinic acid [3482-37-9]; Down 200; 11.6uM; MCF7; HT_HG-U133A	NDST1 ABHD2 ZNF408 PLCG1 PC BBS9	6.74e-06	199	53	6	2802_DN
Drug	Florisil	GRK2 GRK3 AGXT PRKCE PLCG1	1.50e-05	134	53	5	CID000026924
Drug	Ro 31	GRK2 GRK3 PRKCE PLCG1 MMP1	1.92e-05	141	53	5	CID000214797
Drug	phenylisopropyladenosine	GRK2 GRK3 AGXT PRKCE	2.14e-05	70	53	4	CID000005022
Disease	azoospermia (implicated_via_orthology)	NDST3 NDST1 NDST4	1.38e-05	27	51	3	DOID:14227 (implicated_via_orthology)
Disease	granzyme b measurement	GZMH GZMB	1.75e-05	4	51	2	EFO_0020418
Disease	autism spectrum disorder (implicated_via_orthology)	NDST3 NDST1 NDST4 NLGN1	1.40e-04	152	51	4	DOID:0060041 (implicated_via_orthology)
Disease	Bipolar Disorder	NDST3 GRK3 NLGN1 PLCG1 PC LARS2	1.68e-04	477	51	6	C0005586
Disease	intellectual disability (implicated_via_orthology)	NDST3 NDST1 NDST4	3.01e-04	75	51	3	DOID:1059 (implicated_via_orthology)
Disease	Craniosynostosis	ZNF462 BBS9	5.46e-04	20	51	2	C0010278
Disease	Parkinson's disease (biomarker_via_orthology)	GRK2 GRK3	1.24e-03	30	51	2	DOID:14330 (biomarker_via_orthology)
Disease	cortical surface area measurement	FLNB NTN4 DPYSL3 NBEAL1 INPP5A PC BBS9 C17orf58	2.03e-03	1345	51	8	EFO_0010736
Disease	major depressive episode	AGXT FREM3	3.01e-03	47	51	2	EFO_0007634

Protein segments in the cluster

Peptide	Gene	Start	Entry
TMAAPRVHTDYHPGG	AGPAT4-IT1	76	Q9H0P7
KPHASVGTHGYMAPE	GRK3	346	P35626
YSIMGLVHGPNHPLV	ALG1	161	Q9BT22
GYPVHGVEVMPLHTV	B4GALNT2	196	Q8NHY0
MGRVRSPHPYGHRKF	ABHD2	86	P08910
SPHPYGHRKFITMSD	ABHD2	91	P08910
IPGGIDVHTHFQMPY	DPYSL3	66	Q14195
IIGGHEAKPHSRPYM	GZMB	21	P10144
IIGGHEAKPHSRPYM	GZMH	21	P20718
HPKYRIGVGAPVYMA	MACROH2A1	36	O75367
RGVKMIPPGIHFLHY	AAR2	46	Q9Y312
GKMEYHLIPHSLPGH	DTX4	481	Q9Y2E6
KPMHGYNFVVAIPAG	ADAMTS15	691	Q8TE58
KPHASVGTHGYMAPE	GRK2	346	P25098
PVTKHRGYLGVMPAY	CRYM	51	Q14894
GIPTDMGYAVAPHHS	NDST3	411	O95803
HNITVVHMPGKRPFG	NBEAL1	666	Q6ZS30
MRPIGHDGYHPTSVA	ANKS1B	876	Q7Z6G8
LASVMHHLGYPVPGQ	FOXB2	291	Q5VYV0
MPHKFGIHNYKVPTF	PRKCE	241	Q02156
CPEFKPGSRYIVMGH	C17orf58	271	Q2M2W7
MKYGGELVPHFPARV	FLNB	1206	O75369
AFRIMPGAGKPHAHV	INPP5A	391	Q14642
FGKHAPHVVPITMSY	OR51B4	261	Q9Y5P0
GPRGAPAVYSEKVMH	MYO18A	446	Q92614
IPTDMGYAVAPHHSG	NDST1	421	P52848
IPINMGYAVAPHHSG	NDST4	411	Q9H3R1
IRDSGGPKPVMVYIH	NLGN1	206	Q8N2Q7
FHYGAGHPMKPHRLA	HDAC3	16	O15379
MGYLRIFSPHPAKTG	BBS9	46	Q3SYG4
PYASGMPIKKIGHRS	PIPSL	6	A2A3N6
GGPQYVKHHMILPHT	FASTKD5	571	Q7L8L6
AAFPYPMMHGRAVHG	C5orf24	161	Q7Z6I8
FLSPGGPKFIHLMYH	HAUS6	116	Q7Z4H7
MHSIVGSYHKPPERV	CEP57L1	6	Q8IYX8
MEGRLFYRHLGPHSP	FREM3	651	P0C091
VMKGIHQYPGVRYPV	HMGCLL1	136	Q8TB92
ARVHPMTKDPGGHYT	AGXT	121	P21549
MVHVYRSPSFGPKHL	SLITRK6	686	Q9H5Y7
GHPLYSKYMLSVPHG	SH3D19	406	Q5HYK7
PYPSGKLHMGHVRVY	LARS2	91	Q15031
GFRPVKAPGTFHMVH	NTN4	276	Q9HB63
YPKMIAHDFPGIGHK	MMP1	411	P03956
HVKPYVLPFAGRMHA	KBTBD4	411	Q9NVX7
HGKEMPKGYRRPLAH	FOXA3	101	P55318
HPVAPQMFGYAGKEH	SCP2	156	P22307
VGLFGHPGMLHRAKY	SHC4	16	Q6S5L8
YHSPGFPGHVMKVPR	ZC3H6	551	P61129
FRGHMRVHTGEKPYE	ZNF555	411	Q8NEP9
FKAHMLGHRGVRPFP	ZNF408	396	Q9H9D4
GMPYTRPVKFKAAHG	WDR44	476	Q5JSH3
GPDGMPVIYHGHTLT	PLCG1	371	P19174
GIVSHYMKRHPGVFP	ZNF462	1781	Q96JM2
LHYLGHVMVNGPTTP	PC	501	P11498
LTQPMGRHAGKRPYH	ZNF317	181	Q96PQ6