Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	response to chloroquine	MRGPRX1 MRGPRX3 MRGPRX4	1.31e-06	5	106	3	GO:1902349
MousePheno	decreased pruritus	MRGPRX1 MRGPRX3 MRGPRX4	8.87e-06	7	90	3	MP:0010073
Domain	-	LRRC38 LINGO2 LRRTM3 DNAL1 NLRC4 NOD2 LINGO1 LRIG1 FBXO33 NLRC3	1.57e-05	321	107	10	3.80.10.10
Domain	L_dom-like	LRRC38 LINGO2 LRRTM3 DNAL1 NLRC4 NOD2 LINGO1 LRIG1 FBXO33 NLRC3	1.90e-05	328	107	10	IPR032675
Domain	MRGPCRFAMILY	MRGPRX1 MRGPRX3 MRGPRX4	2.92e-05	11	107	3	IPR026234
Domain	Distal-less_N	DLX2 DLX5	9.72e-05	3	107	2	IPR022135
Domain	DLL_N	DLX2 DLX5	9.72e-05	3	107	2	PF12413
Domain	PLC-beta_C	PLCB2 PLCB3	9.72e-05	3	107	2	PF08703
Domain	PLC-beta_C	PLCB2 PLCB3	9.72e-05	3	107	2	IPR014815
Domain	LRR	LRRC38 LINGO2 LRRTM3 DNAL1 NOD2 LINGO1 LRIG1	1.58e-04	201	107	7	PS51450
Domain	Leu-rich_rpt	LRRC38 LINGO2 LRRTM3 DNAL1 NOD2 LINGO1 LRIG1 NLRC3	1.67e-04	271	107	8	IPR001611
Domain	PLC-beta	PLCB2 PLCB3	1.94e-04	4	107	2	IPR016280
Domain	LRRNT	LRRC38 LINGO2 LRRTM3 LRIG1	2.40e-04	53	107	4	PF01462
Domain	LRRNT	LRRC38 LINGO2 LRRTM3 LINGO1 LRIG1	2.50e-04	98	107	5	IPR000372
Domain	LRRNT	LRRC38 LINGO2 LRRTM3 LINGO1 LRIG1	2.50e-04	98	107	5	SM00013
Domain	NACHT	NLRC4 NOD2 NLRC3	2.98e-04	23	107	3	PS50837
Domain	NACHT_NTPase	NLRC4 NOD2 NLRC3	2.98e-04	23	107	3	IPR007111
Domain	Spectrin	SYNE1 SPTA1 ACTN1	2.98e-04	23	107	3	PF00435
Domain	Helicase_C	DHX57 DICER1 CHD5 DDX18 RECQL4	3.76e-04	107	107	5	PF00271
Domain	HELICc	DHX57 DICER1 CHD5 DDX18 RECQL4	3.76e-04	107	107	5	SM00490
Domain	Helicase_C	DHX57 DICER1 CHD5 DDX18 RECQL4	3.92e-04	108	107	5	IPR001650
Domain	HELICASE_CTER	DHX57 DICER1 CHD5 DDX18 RECQL4	4.09e-04	109	107	5	PS51194
Domain	HELICASE_ATP_BIND_1	DHX57 DICER1 CHD5 DDX18 RECQL4	4.09e-04	109	107	5	PS51192
Domain	DEXDc	DHX57 DICER1 CHD5 DDX18 RECQL4	4.09e-04	109	107	5	SM00487
Domain	Helicase_ATP-bd	DHX57 DICER1 CHD5 DDX18 RECQL4	4.27e-04	110	107	5	IPR014001
Domain	EFhand_Ca_insen	SPTA1 ACTN1	4.80e-04	6	107	2	PF08726
Domain	EF-hand_Ca_insen	SPTA1 ACTN1	4.80e-04	6	107	2	IPR014837
Domain	Spectrin_repeat	SYNE1 SPTA1 ACTN1	5.99e-04	29	107	3	IPR002017
Domain	SPEC	SYNE1 SPTA1 ACTN1	8.03e-04	32	107	3	SM00150
Domain	Spectrin/alpha-actinin	SYNE1 SPTA1 ACTN1	8.03e-04	32	107	3	IPR018159
Domain	DEAD/DEAH_box_helicase_dom	DHX57 DICER1 DDX18 RECQL4	8.18e-04	73	107	4	IPR011545
Domain	DEAD	DHX57 DICER1 DDX18 RECQL4	8.18e-04	73	107	4	PF00270
Domain	DNA/RNA_helicase_DEAH_CS	DHX57 CHD5 RECQL4	1.05e-03	35	107	3	IPR002464
Domain	DEAH_ATP_HELICASE	DHX57 CHD5 RECQL4	1.33e-03	38	107	3	PS00690
Domain	LRR_1	LRRC38 LINGO2 LRRTM3 DNAL1 LINGO1 LRIG1	1.64e-03	219	107	6	PF00560
Domain	Transglutaminase-like	TGM4 NGLY1	1.73e-03	11	107	2	IPR002931
Domain	TGc	TGM4 NGLY1	1.73e-03	11	107	2	SM00460
Domain	Transglut_core	TGM4 NGLY1	1.73e-03	11	107	2	PF01841
Domain	Cys-rich_flank_reg_C	LRRC38 LINGO2 LINGO1 LRIG1	1.78e-03	90	107	4	IPR000483
Domain	LRRCT	LRRC38 LINGO2 LINGO1 LRIG1	1.78e-03	90	107	4	SM00082
Domain	-	ANK3 NLRC4 NOD2 NFKB2	2.01e-03	93	107	4	1.10.533.10
Domain	DEATH-like_dom	ANK3 NLRC4 NOD2 NFKB2	2.53e-03	99	107	4	IPR011029
Domain	HEAT	CLASP2 HEATR1 TEX10	2.62e-03	48	107	3	PF02985
Domain	LRR_8	LRRC38 LINGO2 LRRTM3 LINGO1 LRIG1	3.04e-03	171	107	5	PF13855
Domain	EF-hand_like	PLCB2 PLCB3	3.25e-03	15	107	2	PF09279
Domain	PI-PLC-Y	PLCB2 PLCB3	3.25e-03	15	107	2	PF00387
Domain	PLCYc	PLCB2 PLCB3	3.25e-03	15	107	2	SM00149
Domain	PLipase_C_Pinositol-sp_Y	PLCB2 PLCB3	3.25e-03	15	107	2	IPR001711
Domain	PIPLC_Y_DOMAIN	PLCB2 PLCB3	3.25e-03	15	107	2	PS50008
Domain	PI-PLC_fam	PLCB2 PLCB3	3.25e-03	15	107	2	IPR001192
Domain	PLC_EF-hand-like	PLCB2 PLCB3	3.25e-03	15	107	2	IPR015359
Domain	P-loop_NTPase	KIF27 DYNC2H1 MYO19 DNM1L DHX57 DICER1 NLRC4 NOD2 ORC1 CHD5 DDX18 RECQL4	3.36e-03	848	107	12	IPR027417
Domain	LRR_TYP	LRRC38 LINGO2 LRRTM3 LINGO1 LRIG1	3.53e-03	177	107	5	SM00369
Domain	Leu-rich_rpt_typical-subtyp	LRRC38 LINGO2 LRRTM3 LINGO1 LRIG1	3.53e-03	177	107	5	IPR003591
Domain	-	DYNC2H1 MYO19 DNM1L DHX57 DICER1 NLRC4 NOD2 ORC1 CHD5 DDX18 RECQL4	3.65e-03	746	107	11	3.40.50.300
Domain	Post-SET_dom	NSD1 KMT2A	3.70e-03	16	107	2	IPR003616
Domain	PostSET	NSD1 KMT2A	3.70e-03	16	107	2	SM00508
Domain	POST_SET	NSD1 KMT2A	3.70e-03	16	107	2	PS50868
Domain	-	C1orf87 SPTA1 ACTN1 RHBDL3 PLCB2 PLCB3	3.92e-03	261	107	6	1.10.238.10
Domain	HEAT	CLASP2 HEATR1 TEX10	4.49e-03	58	107	3	IPR000357
Domain	PI-PLC-X	PLCB2 PLCB3	4.69e-03	18	107	2	PF00388
Domain	PLCXc	PLCB2 PLCB3	4.69e-03	18	107	2	SM00148
Domain	Ig_I-set	CEACAM5 NFASC LINGO2 LINGO1 LRIG1	4.76e-03	190	107	5	IPR013098
Domain	I-set	CEACAM5 NFASC LINGO2 LINGO1 LRIG1	4.76e-03	190	107	5	PF07679
Domain	PIPLC_X_DOMAIN	PLCB2 PLCB3	5.22e-03	19	107	2	PS50007
Domain	PLipase_C_PInositol-sp_X_dom	PLCB2 PLCB3	5.22e-03	19	107	2	IPR000909
Pubmed	Activation of mas-related G-protein-coupled receptors by the house dust mite cysteine protease Der p1 provides a new mechanism linking allergy and inflammation.	MRGPRX1 MRGPRX3 MRGPRX4	3.16e-08	3	111	3	28768771
Pubmed	The inhibition of high-voltage-activated calcium current by activation of MrgC11 involves phospholipase C-dependent mechanisms.	MRGPRX1 MRGPRX3 MRGPRX4	3.16e-08	3	111	3	26022362
Pubmed	Investigating the role of MRGPRC11 and capsaicin-sensitive afferent nerves in the anti-influenza effects exerted by SLIGRL-amide in murine airways.	MRGPRX1 MRGPRX3 MRGPRX4	3.16e-08	3	111	3	27215903
Pubmed	Proenkephalin A gene products activate a new family of sensory neuron--specific GPCRs.	MRGPRX1 MRGPRX3 MRGPRX4	3.16e-08	3	111	3	11850634
Pubmed	Agonists of the MAS-related gene (Mrgs) orphan receptors as novel mediators of mast cell-sensory nerve interactions.	MRGPRX1 MRGPRX3 MRGPRX4	3.16e-08	3	111	3	18250432
Pubmed	bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells.	MRGPRX1 MRGPRX3 MRGPRX4	3.16e-08	3	111	3	10662793
Pubmed	Mas-related G protein-coupled receptor C11 (Mrgprc11) induces visceral hypersensitivity in the mouse colon: A novel target in gut nociception?	MRGPRX1 MRGPRX3 MRGPRX4	3.16e-08	3	111	3	31119828
Pubmed	Activation of MrgprA3 and MrgprC11 on Bladder-Innervating Afferents Induces Peripheral and Central Hypersensitivity to Bladder Distension.	MRGPRX1 MRGPRX3 MRGPRX4	1.26e-07	4	111	3	33727332
Pubmed	Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection.	MRGPRX1 MRGPRX3 MRGPRX4	1.26e-07	4	111	3	35882236
Pubmed	Molecular Signature of Pruriceptive MrgprA3+ Neurons.	MRGPRX1 MRGPRX3 MRGPRX4	1.26e-07	4	111	3	32234460
Pubmed	Overlap of direct and indirect alloreactive T-cell repertoires when MHC polymorphism is limited to the peptide binding groove.	MRGPRX1 MRGPRX3 MRGPRX4	1.26e-07	4	111	3	11821156
Pubmed	Human sensory neuron-specific Mas-related G protein-coupled receptors-X1 sensitize and directly activate transient receptor potential cation channel V1 via distinct signaling pathways.	MRGPRX1 MRGPRX3 MRGPRX4	1.26e-07	4	111	3	23074220
Pubmed	Tick peptides evoke itch by activating MrgprC11/MRGPRX1 to sensitize TRPV1 in pruriceptors.	MRGPRX1 MRGPRX3 MRGPRX4	1.26e-07	4	111	3	33358893
Pubmed	USP48 alleviates bone cancer pain and regulates MrgC stabilization in spinal cord neurons of male mice.	MRGPRX1 MRGPRX3 MRGPRX4	1.26e-07	4	111	3	36864656
Pubmed	Low maternal care enhances the skin barrier resistance of offspring in mice.	MRGPRX1 MRGPRX3 MRGPRX4	1.26e-07	4	111	3	31295326
Pubmed	MrgprA3 shows sensitization to chloroquine in an acetone-ether-water mice model.	MRGPRX1 MRGPRX3 MRGPRX4	1.26e-07	4	111	3	29064954
Pubmed	A fraction of mouse sperm chromatin is organized in nucleosomal hypersensitive domains enriched in retroposon DNA.	MRGPRX1 MRGPRX3 MRGPRX4	1.26e-07	4	111	3	10504302
Pubmed	A mechanically activated ion channel is functionally expressed in the MrgprB4 positive sensory neurons, which detect stroking of hairy skin in mice.	MRGPRX1 MRGPRX3 MRGPRX4	1.26e-07	4	111	3	28545921
Pubmed	Substance P activates Mas-related G protein-coupled receptors to induce itch.	MRGPRX1 MRGPRX3 MRGPRX4	1.26e-07	4	111	3	28219706
Pubmed	Cloning and functional expression of a novel Gi protein-coupled receptor for adenine from mouse brain.	MRGPRX1 MRGPRX3 MRGPRX4	1.26e-07	4	111	3	17975009
Pubmed	Characterization of new G protein-coupled adenine receptors in mouse and hamster.	MRGPRX1 MRGPRX3 MRGPRX4	1.26e-07	4	111	3	23608776
Pubmed	The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia.	MRGPRX1 MRGPRX3 MRGPRX4	1.26e-07	4	111	3	21775281
Pubmed	Voltage-gated potassium channels involved in regulation of physiological function in MrgprA3-specific itch neurons.	MRGPRX1 MRGPRX3 MRGPRX4	1.26e-07	4	111	3	26874069
Pubmed	Molecular genetic visualization of a rare subset of unmyelinated sensory neurons that may detect gentle touch.	MRGPRX1 MRGPRX3 MRGPRX4	3.15e-07	5	111	3	17618277
Pubmed	Hippocampal short- and long-term plasticity are not modulated by astrocyte Ca2+ signaling.	MRGPRX1 MRGPRX3 MRGPRX4	3.15e-07	5	111	3	20203048
Pubmed	MrgprB4 in trigeminal neurons expressing TRPA1 modulates unpleasant sensations.	MRGPRX1 MRGPRX3 MRGPRX4	3.15e-07	5	111	3	34116733
Pubmed	Astrocytes modulate neural network activity by Ca²+-dependent uptake of extracellular K+.	MRGPRX1 MRGPRX3 MRGPRX4	3.15e-07	5	111	3	22472648
Pubmed	Cross-sensitization of histamine-independent itch in mouse primary sensory neurons.	MRGPRX1 MRGPRX3 MRGPRX4	3.15e-07	5	111	3	23000623
Pubmed	Sensory neuron-specific GPCR Mrgprs are itch receptors mediating chloroquine-induced pruritus.	MRGPRX1 MRGPRX3 MRGPRX4	3.15e-07	5	111	3	20004959
Pubmed	Regional Differences in Itch Transmission.	MRGPRX1 MRGPRX3 MRGPRX4	3.15e-07	5	111	3	38735364
Pubmed	Visualizing the Itch-Sensing Skin Arbors.	MRGPRX1 MRGPRX3 MRGPRX4	6.28e-07	6	111	3	33091423
Pubmed	Genetic identification of C fibres that detect massage-like stroking of hairy skin in vivo.	MRGPRX1 MRGPRX3 MRGPRX4	6.28e-07	6	111	3	23364746
Pubmed	Identification of a bilirubin receptor that may mediate a component of cholestatic itch.	MRGPRX1 MRGPRX3 MRGPRX4	6.28e-07	6	111	3	30657454
Pubmed	Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs.	MRGPRX1 MRGPRX3 MRGPRX4	6.28e-07	6	111	3	26216096
Pubmed	MrgprC11+ sensory neurons mediate glabrous skin itch.	MRGPRX1 MRGPRX3 MRGPRX4	6.28e-07	6	111	3	33876765
Pubmed	A subpopulation of nociceptors specifically linked to itch.	MRGPRX1 MRGPRX3 MRGPRX4	6.28e-07	6	111	3	23263443
Pubmed	Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain.	MRGPRX1 MRGPRX3 MRGPRX4	6.28e-07	6	111	3	24549959
Pubmed	Touch neurons underlying dopaminergic pleasurable touch and sexual receptivity.	MRGPRX1 MRGPRX3 MRGPRX4	1.10e-06	7	111	3	36693373
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	TTC28 ARHGEF5 MYO19 DHX57 DICER1 AP1G1 RHPN2 RECQL4 UGDH KMT2A PLCB3 TNFAIP2	1.20e-06	650	111	12	38777146
Pubmed	Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family.	MRGPRX1 MRGPRX3 MRGPRX4	1.75e-06	8	111	3	12909716
Pubmed	Comparative genomic analysis of eutherian Mas-related G protein-coupled receptor genes.	MRGPRX1 MRGPRX3 MRGPRX4	1.75e-06	8	111	3	24583173
Pubmed	Multiplexed peroxidase-based electron microscopy labeling enables simultaneous visualization of multiple cell types.	MRGPRX1 MRGPRX3 MRGPRX4	2.62e-06	9	111	3	30886406
Pubmed	Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway.	MRGPRX1 MRGPRX3 MRGPRX4	2.62e-06	9	111	3	12397184
Pubmed	Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens.	MRGPRX1 MRGPRX3 MRGPRX4	3.74e-06	10	111	3	33098765
Pubmed	An evolving NGF-Hoxd1 signaling pathway mediates development of divergent neural circuits in vertebrates.	MRGPRX1 MRGPRX3 MRGPRX4	5.12e-06	11	111	3	21151121
Pubmed	A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons.	MRGPRX1 MRGPRX3 MRGPRX4	5.12e-06	11	111	3	11551509
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	CEACAM5 FYTTD1 SYNE1 PPP1R9A MED14 NSD1 DHX57 CLASP2 HEATR1 ACTN1 TEX10 N4BP3 DICER1 ORC1 AP1G1 USP7 KMT2A	5.39e-06	1497	111	17	31527615
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	CEACAM5 DYNC2H1 SYNE1 MED14 C1orf167 HEATR1 ZNF610 AP1G1 DDX18 UGDH USP7 ELAVL1	5.50e-06	754	111	12	35906200
Pubmed	Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation.	NLRC4 PLCB2 PLCB3	6.82e-06	12	111	3	25959047
Pubmed	LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease.	LINGO2 LINGO1	1.01e-05	2	111	2	20369371
Pubmed	USP7 reduces the level of nuclear DICER, impairing DNA damage response and promoting cancer progression.	DICER1 USP7	1.01e-05	2	111	2	37867415
Pubmed	Temporospatial cell interactions regulating mandibular and maxillary arch patterning.	DLX2 DLX5	1.01e-05	2	111	2	10603356
Pubmed	Inhibition of miR-9 de-represses HuR and DICER1 and impairs Hodgkin lymphoma tumour outgrowth in vivo.	DICER1 ELAVL1	1.01e-05	2	111	2	22310293
Pubmed	Genetic and transcriptional analysis of inflammatory bowel disease-associated pathways in patients with GUCY2C-linked familial diarrhea.	NOD2 GUCY2C	1.01e-05	2	111	2	30353760
Pubmed	Actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites.	DNM1L ACTN1	1.01e-05	2	111	2	26609810
Pubmed	The chaperone ERp29 is required for tunneling nanotube formation by stabilizing MSec.	ERP29 TNFAIP2	1.01e-05	2	111	2	30877198
Pubmed	Loss of RNA binding protein, human antigen R enhances mitochondrial elongation by regulating Drp1 expression in SH-SY5Y cells.	DNM1L ELAVL1	1.01e-05	2	111	2	31253394
Pubmed	Simultaneous Ablation of Neuronal Neurofascin and Ankyrin G in Young and Adult Mice Reveals Age-Dependent Increase in Nodal Stability in Myelinated Axons and Differential Effects on the Lifespan.	ANK3 NFASC	1.01e-05	2	111	2	29963618
Pubmed	Parallel ascending spinal pathways for affective touch and pain.	MRGPRX1 MRGPRX3 MRGPRX4	1.12e-05	14	111	3	33116307
Pubmed	A brain-to-spinal sensorimotor loop for repetitive self-grooming.	MRGPRX1 MRGPRX3 MRGPRX4	1.40e-05	15	111	3	34932943
Pubmed	DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon.	MRGPRX1 MRGPRX3 MRGPRX4	1.40e-05	15	111	3	37541195
Pubmed	Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.	HIC1 DCAF16 DDX18 NFKB2 RECQL4 DYRK1B UGDH	1.96e-05	257	111	7	30945288
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CYLD TTC28 ARHGEF5 DNM1L CLASP2 N4BP3 FSIP2 DYRK1B KMT2A PAN3 RNF180 CCDC102A	2.06e-05	861	111	12	36931259
Pubmed	Incoherent feed-forward regulatory loops control segregation of C-mechanoreceptors, nociceptors, and pruriceptors.	MRGPRX1 MRGPRX3 MRGPRX4	2.08e-05	17	111	3	25834056
Pubmed	p75 Is Required for the Establishment of Postnatal Sensory Neuron Diversity by Potentiating Ret Signaling.	MRGPRX1 MRGPRX3 MRGPRX4	2.49e-05	18	111	3	29045838
Pubmed	Negative regulation of endothelin signaling by SIX1 is required for proper maxillary development.	JAG1 DLX2 DLX5	2.49e-05	18	111	3	28455376
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	DCAF1 MYO19 DHX57 HEATR1 ACTN1 TEX10 ORC1 AP1G1 DDX18 NFKB2 RECQL4 UGDH USP7 ELAVL1 ERP29	2.68e-05	1353	111	15	29467282
Pubmed	Repression of Irs2 by let-7 miRNAs is essential for homeostasis of the telencephalic neuroepithelium.	DICER1 DLX2 DLX5	2.95e-05	19	111	3	32985705
Pubmed	C-LTMRs mediate wet dog shakes via the spinoparabrachial pathway.	MRGPRX1 MRGPRX3 MRGPRX4	2.95e-05	19	111	3	38915692
Pubmed	Uncoupling of molecular maturation from peripheral target innervation in nociceptors expressing a chimeric TrkA/TrkC receptor.	MRGPRX1 MRGPRX3 MRGPRX4	2.95e-05	19	111	3	24516396
Pubmed	Tlx3 and Runx1 act in combination to coordinate the development of a cohort of nociceptors, thermoceptors, and pruriceptors.	MRGPRX1 MRGPRX3 MRGPRX4	2.95e-05	19	111	3	22787056
Pubmed	Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation.	NGLY1 SMAD1	3.02e-05	3	111	2	32720893
Pubmed	Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice.	PLCB2 PLCB3	3.02e-05	3	111	2	18079968
Pubmed	The relative role of PLCbeta and PI3Kgamma in platelet activation.	PLCB2 PLCB3	3.02e-05	3	111	2	15705797
Pubmed	Mutually exclusive expression of DLX2 and DLX5/6 is associated with the metastatic potential of the human breast cancer cell line MDA-MB-231.	DLX2 DLX5	3.02e-05	3	111	2	21108812
Pubmed	Transcriptional regulation of BMP-2 activated genes in osteoblasts using gene expression microarray analysis: role of Dlx2 and Dlx5 transcription factors.	DLX2 DLX5	3.02e-05	3	111	2	12957859
Pubmed	Regulation of phospholipase C-beta 3 activity by Na+/H+ exchanger regulatory factor 2.	PLCB2 PLCB3	3.02e-05	3	111	2	10748023
Pubmed	Activation of the Intracellular Pattern Recognition Receptor NOD2 Promotes Acute Myeloid Leukemia (AML) Cell Apoptosis and Provides a Survival Advantage in an Animal Model of AML.	NOD2 KMT2A	3.02e-05	3	111	2	32094205
Pubmed	Intracellular pathogen sensor NOD2 programs macrophages to trigger Notch1 activation.	NOD2 JAG1	3.02e-05	3	111	2	21156799
Pubmed	Phospholipase cbeta is critical for T cell chemotaxis.	PLCB2 PLCB3	3.02e-05	3	111	2	17675482
Pubmed	Identification of a direct Dlx homeodomain target in the developing mouse forebrain and retina by optimization of chromatin immunoprecipitation.	DLX2 DLX5	3.02e-05	3	111	2	14769946
Pubmed	Critical role of the Polycomb and Trithorax complexes in the maintenance of CD4 T cell memory.	KMT2A PMAIP1	3.02e-05	3	111	2	19269851
Pubmed	LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex.	LINGO2 LINGO1	3.02e-05	3	111	2	14686891
Pubmed	Meis1 Regulates Nociceptor Development and Behavioral Response to Tactile Stimuli.	MRGPRX1 MRGPRX3 MRGPRX4	3.47e-05	20	111	3	35875660
Pubmed	Hierarchical Specification of Pruriceptors by Runt-Domain Transcription Factor Runx1.	MRGPRX1 MRGPRX3 MRGPRX4	4.04e-05	21	111	3	28476948
Pubmed	ZBTB20 regulates nociception and pain sensation by modulating TRP channel expression in nociceptive sensory neurons.	MRGPRX1 MRGPRX3 MRGPRX4	4.04e-05	21	111	3	25369838
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	NSD1 DHX57 HEATR1 ACTN1 TEX10 DICER1 DDX18 USP7 KMT2A ELAVL1	4.78e-05	653	111	10	22586326
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	ANK3 SYNE1 SPTA1 PPP1R9A NFASC DNM1L DHX57 CLASP2 SRCIN1 ACTN1 LRIG1 AP1G1 USP7 KMT2A ELAVL1	5.08e-05	1431	111	15	37142655
Pubmed	HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease.	NFKB2 PLCB2 PLCB3	5.35e-05	23	111	3	9730685
Pubmed	Brn3a regulates neuronal subtype specification in the trigeminal ganglion by promoting Runx expression during sensory differentiation.	MRGPRX1 MRGPRX3 MRGPRX4	5.35e-05	23	111	3	20096094
Pubmed	Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain.	MRGPRX1 MRGPRX3 MRGPRX4	5.35e-05	23	111	3	16446141
Pubmed	The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases.	NFKB2 PLCB2 PLCB3	5.35e-05	23	111	3	9278385
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	ANK3 DYNC2H1 SYNE1 SPTA1 ACTN1 AP1G1 DDX18 USP7 KMT2A ELAVL1 ERP29	5.65e-05	807	111	11	30575818
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	KIF27 ANK3 SPTA1 DNM1L SRCIN1 TEX10 AP1G1	5.69e-05	304	111	7	32235678
Pubmed	Patterns of expression for the mRNA corresponding to the four isoforms of phospholipase Cbeta in mouse brain.	PLCB2 PLCB3	6.03e-05	4	111	2	9753089
Pubmed	TNF and IFNγ-induced cell death requires IRF1 and ELAVL1 to promote CASP8 expression.	CYLD ELAVL1	6.03e-05	4	111	2	38319288
Pubmed	Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction.	PLCB2 PLCB3	6.03e-05	4	111	2	10669417
Pubmed	Expression of the Lingo/LERN gene family during mouse embryogenesis.	LINGO2 LINGO1	6.03e-05	4	111	2	18297755
Pubmed	Anthrax toxin induces macrophage death by p38 MAPK inhibition but leads to inflammasome activation via ATP leakage.	NLRC4 NOD2	6.03e-05	4	111	2	21683629
Pubmed	A highly conserved enhancer in the Dlx5/Dlx6 intergenic region is the site of cross-regulatory interactions between Dlx genes in the embryonic forebrain.	DLX2 DLX5	6.03e-05	4	111	2	10632600
Interaction	CUL4A interactions	DCAF1 CYLD HIC1 KIF27 ANK3 SPTA1 DNM1L SRCIN1 DCAF16 TEX10 DICER1 ORC1 AP1G1 NFKB2 RECQL4 UGDH USP7	3.27e-06	854	109	17	int:CUL4A
GeneFamily	NLR family	NLRC4 NOD2 NLRC3	1.72e-04	25	79	3	666
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	CEACAM5 NFASC LINGO2 LINGO1 LRIG1	6.97e-04	161	79	5	593
GeneFamily	Phospholipases	PLCB2 PLCB3 PLD5	8.15e-04	42	79	3	467
GeneFamily	WD repeat domain containing\|DDB1 and CUL4 associated factors	DCAF1 DCAF16	2.76e-03	18	79	2	498
GeneFamily	Phospholipases\|C2 domain containing phospholipases	PLCB2 PLCB3	3.07e-03	19	79	2	832
Coexpression	GSE13522_CTRL_VS_T_CRUZI_Y_STRAIN_INF_SKIN_BALBC_MOUSE_DN	TTC28 DYNC2H1 LINGO2 ACTN1 CC2D2B LRIG1 DYRK1B	2.17e-06	139	111	7	M2928
Coexpression	GAO_ESOPHAGUS_25W_C1_CILIATED_EPITHELIAL_CELLS	KIF27 DYNC2H1 TTC16 SYNE1 C1orf87 DNAL1 C8orf34 CFAP20DC LRIG1 PLCB2 DLEC1	4.14e-06	459	111	11	M39136
Coexpression	GSE37416_CTRL_VS_6H_F_TULARENSIS_LVS_NEUTROPHIL_DN	CYLD HDHD5 NUP58 NOD2 ORC1 DDX18 NGLY1	2.07e-05	196	111	7	M5333
Coexpression	GSE360_L_DONOVANI_VS_M_TUBERCULOSIS_MAC_DN	AP1G1 JAG1 NFKB2 KMT2A DLEC1 DLX5 TNFAIP2	2.28e-05	199	111	7	M5242
Coexpression	GSE360_L_DONOVANI_VS_L_MAJOR_MAC_DN	ACTN1 AP1G1 JAG1 NFKB2 DLX2 DLEC1 TNFAIP2	2.36e-05	200	111	7	M5232
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KIF27 DYNC2H1 SYNE1 C1orf87 SRCIN1 C8orf34 LRRC9 DLEC1	3.28e-08	197	110	8	74a2c6cb8fcfe53dd9a2b36492a16c58f38e51c9
ToppCell	PND07-28-samps-Mesenchymal-Mesothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	SPTA1 LAMA1 CLEC1B NFASC PKHD1L1 SULF1 ALDH3B2	1.24e-07	156	110	7	574f761962a7dd3308bd41fc529dd3ea1b8625f8
ToppCell	PND07-28-samps-Mesenchymal-Mesothelial-Mesothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	SPTA1 LAMA1 CLEC1B NFASC PKHD1L1 SULF1 ALDH3B2	1.24e-07	156	110	7	605d95a900e1443d3f6aae163ef2e893d3293203
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA1 C8orf34 PKHD1L1 COL24A1 SULF1 PLD5	2.91e-06	160	110	6	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAMA1 C8orf34 PKHD1L1 COL24A1 SULF1 PLD5	2.91e-06	160	110	6	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c11-GNLY\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TTC16 SYNE1 NFASC RNF180 NLRC3 CCDC102A	5.91e-06	181	110	6	5cecbafc29cc95896e6ccb2c74d9237b9aaece69
ToppCell	Hippocampus-Endothelial\|Hippocampus / BrainAtlas - Mouse McCarroll V32	HIC1 ARHGEF5 LAMA1 FRK JAG1 CCDC102A	8.28e-06	192	110	6	36deadab892d3e639a71f33697bb2d3cbbaa5372
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRRC38 C8orf34 SULF1 DLX2 DLX5 ECE2	8.28e-06	192	110	6	67d6230e32d446dcb12047fae2c3f1faa80dd720
ToppCell	Control_saline-Epithelial_airway-airway_epithelial-Ciliated\|Control_saline / Treatment groups by lineage, cell group, cell type	KIF27 TTC16 C1orf87 C8orf34 LRRC9 DLEC1	9.04e-06	195	110	6	60067b5359174f0d1a8b5748bfc0690762e9e740
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	ANK3 TTC28 PPP1R9A CLASP2 LINGO1 PAN3	1.01e-05	199	110	6	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	ANK3 NFASC LINGO1 CHD5 DLX2 DLX5	1.01e-05	199	110	6	77b4aa00f14b86ef5db0490be98787e063979541
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-E\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PPP1R9A LRRTM3 FSIP2 LINGO1 RHBDL3	4.16e-05	155	110	5	77fdae85d36efb776db977eb424b32487ef222e4
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ANK3 DYNC2H1 LINGO2 TGM4 ALDH3B2	4.42e-05	157	110	5	2c5295043611bac7dfa4aef2146681bce4a33a8f
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Six3\|Thalamus / BrainAtlas - Mouse McCarroll V32	LRRC38 FSIP2 DLX2 DLX5	5.11e-05	82	110	4	47b131333ab84b70d2abe3fc17e63de504214b1b
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)\|Cerebellum / BrainAtlas - Mouse McCarroll V32	NOD2 RECQL4 NLRC3 PMAIP1	5.88e-05	85	110	4	bb9555652e93620d5aeeb71e915b3978a437407d
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)--\|Cerebellum / BrainAtlas - Mouse McCarroll V32	NOD2 RECQL4 NLRC3 PMAIP1	5.88e-05	85	110	4	f7935c3206310adafdecb75149c3b06c38e7780c
ToppCell	Cerebellum-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)-\|Cerebellum / BrainAtlas - Mouse McCarroll V32	NOD2 RECQL4 NLRC3 PMAIP1	5.88e-05	85	110	4	43f6911b032718d8ba75fb7bba5f9b536a4b3260
ToppCell	facs-Aorta-Heart-3m-Endothelial-endocardial_endothelial_cells\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLEC1B PKHD1L1 CLCA1 OTOGL SULF1	5.93e-05	167	110	5	a4a795751644b22af616335379e64ae95175180c
ToppCell	BAL-Severe-cDC_5\|Severe / Compartment, Disease Groups and Clusters	CEACAM5 NFASC N4BP3 RHBDL3 PMAIP1	6.10e-05	168	110	5	857a80c217a5513553460798a625612031bc7bb7
ToppCell	Control\|World / group, cell type (main and fine annotations)	CEACAM5 ANK3 SYNE1 PPP1R9A C8orf34	6.10e-05	168	110	5	a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling-Cycling_Distal_Convoluted_Tubule_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MYO19 ORC1 CFAP20DC RECQL4 RHBDL3	6.27e-05	169	110	5	e7514956b2e4298222ec443f98b2f5289451786e
ToppCell	Frontal_cortex-Neuronal-Inhibitory\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	LRRC38 DLX2 DLX5 PLD5 ECE2	6.27e-05	169	110	5	78eb70dd916724e476eabccf18fb7fcec4210308
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTA1 PKHD1L1 COL24A1 OTOGL PLD5	6.27e-05	169	110	5	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ANK3 C1orf87 ACTN1 SCEL PMAIP1	6.82e-05	172	110	5	bd73fd3520064d430a153cfdd5c2858b6c184c59
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ANK3 C1orf87 ACTN1 SCEL PMAIP1	6.82e-05	172	110	5	47ee78ed3ba6516dad8f12dbf70bca5ed1c60aff
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-neuron_precursor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CLEC1B RHBDL3 DLX2 DLX5 PMAIP1	7.40e-05	175	110	5	2ce8bcf9926862e723219b4246388428d0c3fdee
ToppCell	droplet-Lung-30m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l5\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ACTN1 TEX10 BBS9 PKHD1L1 LRIG1	7.60e-05	176	110	5	218a072882d387adbbad6916d7214099c7354465
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LRRC38 SULF1 DLX2 PLD5 TNFAIP2	7.60e-05	176	110	5	682a1dfcc507ec540f5fadf08e872533ea9f0291
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	C8orf34 DLX2 DLX5 PLD5 ECE2	8.02e-05	178	110	5	3c973aac16988e88f5677d3d695dd772ccfd6570
ToppCell	PCW_13-14-Neuronal-Neuronal_postreplicative-neuro_neuronal_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	NFASC LINGO2 SRCIN1 DLX2 PLD5	8.23e-05	179	110	5	af0b54c9ea0b6e4210f22dbb6e88ecd3276a5f86
ToppCell	droplet-Heart-4Chambers-18m-Neuronal-cardiac_neuron\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANK3 CLASP2 SRCIN1 CHD5 DLX2	8.90e-05	182	110	5	6fdaf3c8c3952a8f14dd7288e523ed58eb1d3517
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-Tuft-related-Microfold_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANKRD22 RHPN2 NFKB2 TNFAIP2 ABHD11	8.90e-05	182	110	5	cee5f1872d6464e380995323544a4cd567add370
ToppCell	10x5'v1-week_17-19-Hematopoietic-MK-MK\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CLEC1B ACTN1 PKHD1L1 COL24A1 RHBDL3	9.13e-05	183	110	5	9c66a40c355387f805dbdca4162dd05af5c1d8d4
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTA1 LAMA1 PKHD1L1 COL24A1 OTOGL	9.37e-05	184	110	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTA1 LAMA1 PKHD1L1 COL24A1 OTOGL	9.37e-05	184	110	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTA1 LAMA1 PKHD1L1 COL24A1 OTOGL	9.37e-05	184	110	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	C8orf34 DLX2 DLX5 PLD5 ECE2	9.61e-05	185	110	5	bdfa8c284bbc5e85c806327fbb7778cf16242a38
ToppCell	COVID-19-Fibroblasts-Airway_smooth_muscle\|COVID-19 / group, cell type (main and fine annotations)	TTC28 NFASC ACTN1 SULF1 JAG1	1.01e-04	187	110	5	464a0c3b92b778911b5f9cd73642e09e3472063a
ToppCell	LA-13._Vascular_Smooth_Muscle\|LA / Chamber and Cluster_Paper	CLASP2 ACTN1 C8orf34 PLD5 RNF180	1.04e-04	188	110	5	34e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell	PCW_07-8.5-Neuronal-Neuronal_postreplicative-neuro_immature_neuronal_(2)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	NFASC LINGO2 DLX2 DLX5 PLD5	1.06e-04	189	110	5	de06ef69f3f97b3f21dc269eb6965da9b2f6e3f8
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	NFASC LRRTM3 ACTN1 JAG1 PLD5	1.09e-04	190	110	5	d6b3a92119b210974a32af3fe9875d60eb02761e
ToppCell	droplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DNAL1 PKHD1L1 CLCA1 SULF1 JAG1	1.09e-04	190	110	5	3cf464664d6aa22b212e60b70885953887e92483
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-neuron_precursor\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NFASC CLASP2 DLX2 DLX5 PMAIP1	1.12e-04	191	110	5	a53616c84178eb6c29b48662358765b082df3f97
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-oligodendrocyte_precursor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRTM3 SCEL LINGO1 UGDH RNF180	1.12e-04	191	110	5	ece87127f85939e61b1048d968ed96f0e87c3a79
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Macroglial-Oligodendrocyte_progenitor_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRTM3 SCEL LINGO1 UGDH RNF180	1.12e-04	191	110	5	478e8341ee03b05501e2233e02cef5f97492c95d
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	DYNC2H1 SYNE1 BBS9 C8orf34 NLRC3	1.17e-04	193	110	5	ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC ACTN1 SULF1 NFKB2 PLD5	1.20e-04	194	110	5	90efdbd7f1c85fd7fd622b10340250b1d8fc1197
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NFASC ACTN1 SULF1 NFKB2 PLD5	1.20e-04	194	110	5	df82cce5ebeb73740b02cf816c6df82253cfd566
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KIF27 DYNC2H1 SYNE1 C1orf87 DLEC1	1.20e-04	194	110	5	4a2c127c90d1fefe604fcb9e796577d21b489dd6
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	ANK3 DYNC2H1 SYNE1 C8orf34 LRIG1	1.23e-04	195	110	5	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	COVID-19_Severe-Classical_Monocyte-cMono_4\|Classical_Monocyte / Disease condition and Cell class	HIC1 ANKRD22 NFKB2 TNFAIP2 PMAIP1	1.23e-04	195	110	5	1992a1673b7213e25f3c76ac77da35c57daceddd
ToppCell	Control-Multiplet\|Control / Disease state, Lineage and Cell class	ANK3 SYNE1 PPP1R9A C8orf34 LRIG1	1.23e-04	195	110	5	618900c80bea09d46dad3f741bd1bff8bf0a64ee
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	ANK3 DYNC2H1 SYNE1 C8orf34 LRIG1	1.23e-04	195	110	5	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	Control-Multiplet-Multiplet\|Control / Disease state, Lineage and Cell class	ANK3 SYNE1 PPP1R9A C8orf34 LRIG1	1.23e-04	195	110	5	06ac685855e14e4dd2cbe6d0e73f894f2eeff91f
ToppCell	nucseq-Epithelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ANK3 SYNE1 PPP1R9A SCEL C8orf34	1.23e-04	195	110	5	9406866f99555198a9be311fbd65751b70f35446
ToppCell	Posterior_cortex-Endothelial\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	HIC1 ARHGEF5 FRK JAG1 CCDC102A	1.23e-04	195	110	5	988e3449691cc228cb55e5e30355136c97b12262
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	ANK3 TTC28 PPP1R9A LINGO1 PAN3	1.26e-04	196	110	5	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	Bronchial-NucSeq-Stromal-Myofibroblastic-Muscle_perivascular_immune_recruiting\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NFASC LRRTM3 ACTN1 SULF1 JAG1	1.29e-04	197	110	5	cfb3dc4b401800e33c82cfc3baee69dbbd16ac8c
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	ANK3 NFASC LINGO1 DLX2 DLX5	1.29e-04	197	110	5	2d92b0483d57541aee382dda80e42cf66e813d6b
ToppCell	distal-Epithelial-Basal-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CEACAM5 CFAP20DC DLX2 DLX5 PMAIP1	1.29e-04	197	110	5	75b4292ce2ad7f9c8b6a4781e1cb71f5b18b74e3
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	ANK3 TTC28 PPP1R9A LINGO1 PAN3	1.32e-04	198	110	5	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	LPS_only-Epithelial_airway-airway_epithelial-Ciliated\|LPS_only / Treatment groups by lineage, cell group, cell type	KIF27 TTC16 C1orf87 LRRC9 DLEC1	1.32e-04	198	110	5	6d90b541fde357fbb40f8f7d4e8628a48b679718
ToppCell	3'-GW_trimst-1-SmallIntestine-Neuronal-neuron_precursor-cycling_neuroblast\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NFASC DLX2 DLX5 PLD5 PMAIP1	1.32e-04	198	110	5	2ee8ac82ef1b8ebabc8dd824211bbb471f2af8ac
ToppCell	distal-Epithelial-Differentiating_Basal-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CEACAM5 DLX2 DLX5 ALDH3B2 PMAIP1	1.35e-04	199	110	5	a1b87c74fe3106ff8bf1c6ff4048d0c3d3fee7ba
ToppCell	Sepsis-Leuk-UTI-Lymphocyte-B-Plasmablast\|Leuk-UTI / Disease, condition lineage and cell class	HIC1 C1orf167 PKHD1L1 RECQL4 PCDHB1	1.35e-04	199	110	5	1b17e6d5e6b994dec65efae2667f4f1f438161b1
ToppCell	distal-Epithelial-Differentiating_Basal\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CEACAM5 DLX2 DLX5 ALDH3B2 PMAIP1	1.35e-04	199	110	5	286d52f25120293620bdbfd62b832f08e118adf6
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	ANK3 NFASC LINGO1 CHD5 DLX5	1.35e-04	199	110	5	5de2a32bc2e9c752eb19a013b1807949153728fc
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DYNC2H1 COL24A1 SULF1 RECQL4 DLX5	1.35e-04	199	110	5	abd6117f8a3d7e798d8471c16d97b34aaf50fc9c
ToppCell	LPS_IL1RA_TNF-Epithelial_airway-airway_epithelial-Ciliated\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	KIF27 TTC16 C1orf87 LRRC9 DLEC1	1.38e-04	200	110	5	96701a4d57753f5ec0dd5c7550054bbcc946bc5f
ToppCell	Bronchus_Control_(B.)-Epithelial-TX-Ciliated\|Bronchus_Control_(B.) / Sample group, Lineage and Cell type	DYNC2H1 SYNE1 C1orf87 DNAL1 DLEC1	1.38e-04	200	110	5	6a2ccc71a0cbe04a542c379b28b5006de53981c3
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26-Neuronal-GABAergic_neurons\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	ANK3 SRCIN1 CHD5 DLX2 DLX5	1.38e-04	200	110	5	bad32a95b759fad509401b07bc96a56687c2a592
ToppCell	Bronchial-NucSeq-Stromal-Myofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NFASC LRRTM3 ACTN1 SULF1 JAG1	1.38e-04	200	110	5	a66449b22b39dd6987fc2c3ed160d24564234ced
ToppCell	LPS_IL1RA_TNF-Epithelial_airway-airway_epithelial\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	TTC16 C1orf87 LRRC9 CLCA1 DLEC1	1.38e-04	200	110	5	da12821e8a0657869ca0f75d351cce2d7605a505
ToppCell	LPS_IL1RA_TNF-Epithelial_airway\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	TTC16 C1orf87 LRRC9 CLCA1 DLEC1	1.38e-04	200	110	5	72c1d9eeaed4b3ee6b6c602e8aa29efc2e8744eb
Drug	N(6)-(delta(2)-isopentenyl)adenine	NUP58 JAG1 TNFAIP2 PMAIP1	1.44e-06	18	109	4	ctd:C001478
Drug	Mephenytoin [50-12-4]; Up 200; 18.4uM; MCF7; HT_HG-U133A	DCAF1 ANK3 TTC28 VPS50 NOD2 NFKB2 DLX2 TNFAIP2	5.09e-06	198	109	8	6275_UP
Disease	Weaver syndrome	NSD1 KMT2A	1.27e-04	5	106	2	C0265210
Disease	Alzheimer disease, age at onset	LAMA1 CFAP20DC OTOGL DDX18 KCNN2 DLX5 PMAIP1	2.46e-04	343	106	7	EFO_0004847, MONDO_0004975
Disease	waist-hip ratio	ANK3 TTC28 DYNC2H1 NSD1 LINGO2 SCEL TEX10 C8orf34 COL24A1 THADA PLCB3 DLEC1 TBC1D23	4.56e-04	1226	106	13	EFO_0004343
Disease	leprosy	CYLD NFASC BBS9 NOD2	5.29e-04	103	106	4	EFO_0001054
Disease	etiocholanolone glucuronide measurement	AKR1D1 NLRC4	2.10e-03	19	106	2	EFO_0800362
Disease	Liver carcinoma	CYLD CLEC1B ORC1 KCNN2 KMT2A ERP29 NLRC3	2.40e-03	507	106	7	C2239176
Disease	hemoglobin A1 measurement	DCAF1 SPTA1 THADA LINGO1 LRIG1 JAG1 PLCB3	2.76e-03	520	106	7	EFO_0007629
Disease	Bronchiectasis	DNAL1 NFKB2	2.82e-03	22	106	2	C0006267
Disease	dilated cardiomyopathy (implicated_via_orthology)	DNM1L DICER1 JAG1	3.03e-03	80	106	3	DOID:12930 (implicated_via_orthology)
Disease	sensory peripheral neuropathy, remission	KMT2A DLEC1	3.08e-03	23	106	2	EFO_0009785, MONDO_0002321
Disease	Colorectal Neoplasms	SYNE1 LAMA1 RHPN2 GUCY2C CHD5	3.30e-03	277	106	5	C0009404
Disease	acute myeloid leukemia (is_implicated_in)	NSD1 KMT2A DLEC1	3.48e-03	84	106	3	DOID:9119 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
QSNLQSLARRRQGKA	C1orf167	291	Q5SNV9
INFNTLQTKLRLSNR	ACTN1	336	P12814
RLKNNQSKFFRVLNS	CHD5	851	Q8TDI0
LANRNGTKYLARTLN	DNM1L	276	O00429
GLVKSLGVSNFNRRQ	AKR1D1	161	P51857
NFNSIAKILAQQTGR	ABHD11	81	Q8NFV4
HKNLFRLFLRQNTQG	ARHGEF5	1461	Q12774
RLQLSNGNRTLTLFN	CEACAM5	546	P06731
ARQALLKQGQDNLSS	ERP29	176	P30040
NRKRLNQSAENGSSL	SPATA5	6	Q8NB90
LQSKQGNRGQLQRTL	C8orf34	131	Q49A92
VSFLLRRNANVNLKN	ANKRD22	56	Q5VYY1
NQKQFQRLRALLGCS	ALDH3B2	206	P48448
RNGKRTVFLVNSANQ	DICER1	91	Q9UPY3
KSKRFQLLQLRNAGQ	CC2D2B	726	Q6DHV5
SFQLAALQRRFQKTQ	DLX2	161	Q07687
SFQLAALQRRFQKTQ	DLX5	146	P56178
LNGALQFATKQLSRT	DCAF16	141	Q9NXF7
FRGVSLNLTRKLAQQ	DYRK1B	206	Q9Y463
NGRLNIDNLNLSFRK	C1orf87	316	Q8N0U7
SLLARGRSSAQNKQV	NSD1	1316	Q96L73
ANSLQKRQAAGIRSQ	GUCY2C	1031	P25092
RKSLQNRQVGSLLIF	PCDHB1	6	Q9Y5F3
QLNRLRNLKFLFLQG	LRRC9	1221	Q6ZRR7
NILGRFLLNNDKNIR	AP1G1	311	O43747
KQRRQAPINFTSRLN	DCAF1	1041	Q9Y4B6
KPQRINNLFGNTRNL	MAGEE2	211	Q8TD90
FQGLNSLEVLKLQRN	LRIG1	231	Q96JA1
RDTINGLNKQRQLFL	NGLY1	411	Q96IV0
GLNKQRQLFLSENRR	NGLY1	416	Q96IV0
NALKVNSSLRRLNLQ	NLRC3	996	Q7RTR2
LKNFQQLNLAGNRVS	NLRC4	936	Q9NPP4
NNSSRFGKFIQLQLN	MYO19	191	Q96H55
RQLLLQLNNQRTKGF	HIC1	31	Q14526
RSIGALNKINFNTRF	KCNN2	286	Q9H2S1
IRNNRNLQKFSLFGD	FBXO33	196	Q7Z6M2
KNINSNGENLARRLT	FSIP2	5936	Q5CZC0
FQKGTRQLLGSRTQL	ECE2	91	P0DPD6
NRARNIRNKPTVNFS	KIF27	336	Q86VH2
FNNLFNLRSLRLKGN	LINGO2	101	Q7L985
NNLFNLRTLGLRSNR	LINGO1	116	Q96FE5
SAGRLVKLSLANNNL	LRRC38	126	Q5VT99
GSFRQRQNRQNLKLV	MRGPRX3	276	Q96LB0
RAINTLNGLRLQSKT	ELAVL1	76	Q15717
RQRNLKFQGASNLTL	DDX18	21	Q9NVP1
NQGNLFQSFTRLKSA	BBS9	716	Q3SYG4
QLANLTVANGRVKFR	MED14	211	O60244
GSNINVLKTLNLRFR	IFFO1	71	Q0D2I5
LFNDFGALNISQRRK	PAN3	216	Q58A45
IRQQLRFLGNSKSDQ	ORC1	391	Q13415
NILAQNASRNTFLRK	PLCB3	141	Q01970
RNKFGTALSNRIRLQ	NFASC	121	O94856
RNSIQLLKRLGSGQF	FRK	231	P42685
TVLRGSGNLLRQLNK	DYNC2H1	1871	Q8NCM8
AAFLRLFQRALQNKQ	DYNC2H1	3521	Q8NCM8
ATQLRRFGDKLNFRQ	PMAIP1	26	Q13794
TFVSQANALQRKGRA	DHX57	951	Q6P158
RQQQNAPLFGKIRSA	CCDC102A	511	Q96A19
SLLLGRNANVNLSNK	ANK3	681	Q12955
RSNARLKQLSFAGVN	KMT2A	3701	Q03164
NLLNLFQRAELSKNG	HEATR1	556	Q9H583
NLRILSLGRNNIKNL	DNAL1	71	Q4LDG9
SLFKNRNRLSKGLQI	CYLD	111	Q9NQC7
LRLGQKATNSIQIRN	DLEC1	871	Q9Y238
NGFNENRQKRALLAA	OTOGL	41	Q3ZCN5
KQLLSLAANGIQRNT	NUP58	291	Q9BVL2
ANFSLGSINQRLNKR	RNF180	361	Q86T96
TFNLKASRGNDRNRI	JAG1	106	P78504
ENFNLGRASVNNLLK	THADA	146	Q6YHU6
GQRLFEKLLQLTSQN	PLD5	166	Q8N7P1
SRRSGLNQNLTLKSQ	SYNE1	6576	Q8NF91
QRLNLDSNKLTFIGQ	LRRTM3	281	Q86VH5
NKRSNSFRQAILQGN	RHBDL3	101	P58872
QALLTLLQGKRFQNL	RECQL4	686	O94761
QRSSRFLKEGNNLSR	LAMA1	1946	P25391
AALKAFRRLVNSQGQ	HDHD5	66	Q9BXW7
RKTAALQNVNILGSF	TGM4	496	P49221
GSFRQRQNRQNLKLV	MRGPRX1	276	Q96LB2
GSFRQRQNRQNLKLV	MRGPRX4	276	Q96LA9
TGRSKLQNQRAALNQ	RHPN2	31	Q8IUC4
KNRFCLGLLSNVNRN	SMAD1	306	Q15797
FINRGTSITRNSKNQ	CFAP20DC	116	Q6ZVT6
NSGFALKRNVLGRNL	CIR1	176	Q86X95
NENRTGTLQQLAKRF	CLEC1B	66	Q9P126
NRLNRLNQAGQLFLL	CLCA1	321	A8K7I4
GLQNLLKNQRTLSRV	CLASP2	676	O75122
RVNNAFLFSIRNKNR	COL24A1	116	Q17RW2
LQLFQAGRKIYRSNQ	ZNF610	136	Q8N9Z0
FLFRRGLKVQAQLNT	FYTTD1	191	Q96QD9
TQASLGLLANQRKRQ	VPS50	151	Q96JG6
RRIFDANTKPNLNLQ	UGDH	141	O60701
RGKQLTNYRANVIAN	TNFAIP2	411	Q03169
SGNNFRRKLCLSQLQ	ZNF33B	306	Q06732
LLFNLLQGNLLKNAR	NOD2	406	Q9HC29
ASDLRGQLQQLRKLQ	SRCIN1	661	Q9C0H9
LTLGLQRSNRDQIKN	SLC35A5	281	Q9BS91
NPRARKNRSQIALFQ	SPDYE16	256	A6NNV3
NPRARKNRSQIALFQ	SPDYE18	296	P0DV79
NKSLNRNQGLDSLFR	SCEL	261	O95171
RKGLAYIQSRQALNS	TBC1D23	626	Q9NUY8
GSRLNSKQLNRLLGV	TEX10	471	Q9NXF1
GLALQRQKALSNAAN	SPTA1	251	P02549
RQKALSNAANLQRFK	SPTA1	256	P02549
NIALSSNGKNVRILR	PKHD1L1	176	Q86WI1
NQKQRDSRLNSLLFP	PLCB2	246	Q00722
LSLAQSLNNSQAKFR	TTC28	701	Q96AY4
SLNNSQAKFRALGNL	TTC28	706	Q96AY4
RAKSRQLLQNIFGAR	TTC16	446	Q8NEE8
DSSFQGLILKRSNRN	ZNF354A	101	O60765
GNNFFLQRSSIGKNR	NAE1	71	Q13564
SQRKSQRQFLRNQGT	SULF1	516	Q8IWU6
NSLLQTLFFTNQLRK	USP7	226	Q93009
QRLSQPNGFKRQCLL	THEGL	271	P0DJG4
LKTQLRGSRAQAQAQ	N4BP3	401	O15049
LSLRNNRGSLLFQKR	MYOZ3	41	Q8TDC0
NFAATVLRNTKGNVR	PPP1R9A	571	Q9ULJ8
KLRANVNARTFAGNT	NFKB2	656	Q00653