Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	phosphatidylcholine transfer activity	PITPNB PITPNA	7.41e-05	6	45	2	GO:0120019
GeneOntologyMolecularFunction	sterol ester esterase activity	LIPA LIPE	1.04e-04	7	45	2	GO:0004771
GeneOntologyMolecularFunction	phosphatidylinositol transfer activity	PITPNB PITPNA	2.70e-04	11	45	2	GO:0008526
GeneOntologyBiologicalProcess	lipid localization	PLA2R1 PITPNB LIPA FTO GDF9 OSBPL3 SLC22A2 PITPNA	3.14e-05	565	46	8	GO:0010876
Domain	IP_trans	PITPNB PITPNA	5.65e-05	5	45	2	PF02121
Domain	PI_transfer	PITPNB PITPNA	8.46e-05	6	45	2	IPR001666
Domain	TGc	NGLY1 TGM6	3.08e-04	11	45	2	SM00460
Domain	Transglut_core	NGLY1 TGM6	3.08e-04	11	45	2	PF01841
Domain	Transglutaminase-like	NGLY1 TGM6	3.08e-04	11	45	2	IPR002931
Domain	-	PITPNB PITPNA	1.39e-03	23	45	2	3.30.530.20
Domain	START-like_dom	PITPNB PITPNA	1.39e-03	23	45	2	IPR023393
Domain	TGF-beta-rel	GDF5 GDF9	2.69e-03	32	45	2	IPR015615
Domain	TGFb_CS	GDF5 GDF9	2.69e-03	32	45	2	IPR017948
Domain	TGFB	GDF5 GDF9	3.58e-03	37	45	2	SM00204
Domain	TGF_BETA_2	GDF5 GDF9	3.58e-03	37	45	2	PS51362
Domain	TGF_beta	GDF5 GDF9	3.58e-03	37	45	2	PF00019
Domain	TGF-b_C	GDF5 GDF9	3.58e-03	37	45	2	IPR001839
Domain	TGF_BETA_1	GDF5 GDF9	3.58e-03	37	45	2	PS00250
Domain	-	GDF5 GDF9	1.14e-02	67	45	2	2.10.90.10
Domain	Cystine-knot_cytokine	GDF5 GDF9	1.14e-02	67	45	2	IPR029034
Pathway	REACTOME_METABOLISM_OF_LIPIDS	ELOVL3 PLA2R1 PITPNB LIPE IDI1 MSMO1 PIK3CG OSBPL3 ST6GALNAC5 ETNK2	7.59e-06	757	34	10	M27451
Pathway	REACTOME_METABOLISM_OF_LIPIDS	ELOVL3 PLA2R1 PITPNB IDI1 MSMO1 PIK3CG OSBPL3 ST6GALNAC5 ETNK2	1.13e-05	620	34	9	MM15193
Pathway	WP_CHOLESTEROL_BIOSYNTHESIS_PATHWAY_IN_HEPATOCYTES	ELOVL3 IDI1 MSMO1 OSBPL3	1.41e-04	111	34	4	M48065
Pathway	WP_CHOLESTEROL_METABOLISM_WITH_BLOCH_AND_KANDUTSCHRUSSELL_PATHWAYS	ELOVL3 IDI1 MSMO1	1.93e-04	47	34	3	M39853
Pathway	WP_CHOLESTEROL_METABOLISM_WITH_BLOCH_AND_KANDUTSCHRUSSELL_PATHWAYS	ELOVL3 IDI1 MSMO1	2.61e-04	52	34	3	MM15920
Pathway	WP_CHOLESTEROL_BIOSYNTHESIS	IDI1 MSMO1	5.81e-04	15	34	2	MM15921
Pathway	WP_CHOLESTEROL_BIOSYNTHESIS_PATHWAY	IDI1 MSMO1	5.81e-04	15	34	2	M39608
Pathway	WP_CHOLESTEROL_METABOLISM	LIPA IDI1 MSMO1	6.82e-04	72	34	3	M46457
Pathway	KEGG_STEROID_BIOSYNTHESIS	LIPA MSMO1	7.51e-04	17	34	2	M5872
Pathway	WP_CHOLESTEROL_SYNTHESIS_DISORDERS	IDI1 MSMO1	8.43e-04	18	34	2	M45528
Pathway	BIOCARTA_PAR1_PATHWAY	ROCK1 PIK3CG	9.41e-04	19	34	2	MM1514
Pathway	BIOCARTA_PAR1_PATHWAY	ROCK1 PIK3CG	9.41e-04	19	34	2	M3494
Pathway	BIOCARTA_ECM_PATHWAY	ROCK1 PIK3CG	9.41e-04	19	34	2	M6355
Pathway	BIOCARTA_ECM_PATHWAY	ROCK1 PIK3CG	1.15e-03	21	34	2	MM1390
Pathway	REACTOME_PHOSPHOLIPID_METABOLISM	PLA2R1 PITPNB PIK3CG ETNK2	1.21e-03	196	34	4	MM14591
Pubmed	Cloning and expression of human cDNA encoding phosphatidylinositol transfer protein beta.	PITPNB PITPNA	1.79e-06	2	47	2	8541325
Pubmed	Defective Lysosomal Lipolysis Causes Prenatal Lipid Accumulation and Exacerbates Immediately after Birth.	LIPA LIPE	1.79e-06	2	47	2	34638755
Pubmed	Phospholipid transfer proteins.	PITPNB PITPNA	1.79e-06	2	47	2	1883207
Pubmed	Dynamics of lipid transfer by phosphatidylinositol transfer proteins in cells.	PITPNB PITPNA	1.79e-06	2	47	2	18636990
Pubmed	Lysosomal acid lipase is the major acid retinyl ester hydrolase in cultured human hepatic stellate cells but not essential for retinyl ester degradation.	LIPA LIPE	1.79e-06	2	47	2	32361002
Pubmed	Biochemical and biological functions of class I phosphatidylinositol transfer proteins.	PITPNB PITPNA	1.79e-06	2	47	2	17490911
Pubmed	Specific and nonspecific membrane-binding determinants cooperate in targeting phosphatidylinositol transfer protein beta-isoform to the mammalian trans-Golgi network.	PITPNB PITPNA	1.79e-06	2	47	2	16540520
Pubmed	Biological functions of phosphatidylinositol transfer proteins.	PITPNB PITPNA	1.79e-06	2	47	2	15052341
Pubmed	Structure of PITPbeta in complex with phosphatidylcholine: comparison of structure and lipid transfer to other PITP isoforms.	PITPNB PITPNA	1.79e-06	2	47	2	16274224
Pubmed	Genetic ablation of phosphatidylinositol transfer protein function in murine embryonic stem cells.	PITPNB PITPNA	1.79e-06	2	47	2	11907258
Pubmed	An isoform of the phosphatidylinositol-transfer protein transfers sphingomyelin and is associated with the Golgi system.	PITPNB PITPNA	1.79e-06	2	47	2	7654206
Pubmed	A novel variant near LSP1P3 is associated with knee osteoarthritis in the Chinese population.	GDF5 FTO	5.36e-06	3	47	2	32103374
Pubmed	The anti-apoptotic activity associated with phosphatidylinositol transfer protein alpha activates the MAPK and Akt/PKB pathway.	PITPNB PITPNA	5.36e-06	3	47	2	18501717
Pubmed	Phosphatidylinositol transfer proteins regulate megakaryocyte TGF-β1 secretion and hematopoiesis in mice.	PITPNB PITPNA	5.36e-06	3	47	2	30042096
Pubmed	Cloning and characterization of a novel human phosphatidylinositol transfer protein, rdgBbeta.	PITPNB PITPNA	1.07e-05	4	47	2	10531358
Pubmed	Phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) binds and transfers phosphatidic acid.	PITPNB PITPNA	1.07e-05	4	47	2	22822086
Pubmed	Structure of a multifunctional protein. Mammalian phosphatidylinositol transfer protein complexed with phosphatidylcholine.	PITPNB PITPNA	1.07e-05	4	47	2	11104777
Pubmed	The DNA sequence and comparative analysis of human chromosome 5.	EIF4E1B CPLANE1 GDF9	1.46e-04	75	47	3	15372022
Pubmed	Phosphatidylinositol transfer protein/planar cell polarity axis regulates neocortical morphogenesis by supporting interkinetic nuclear migration.	PITPNB PITPNA	1.61e-04	14	47	2	35649377
Pubmed	A genome-wide association study on obesity and obesity-related traits.	PITPNB FTO	1.86e-04	15	47	2	21552555
Pubmed	A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.	LIPA BCAP29	2.40e-04	17	47	2	21378988
Pubmed	The DNA sequence of human chromosome 7.	GRM3 BCAP29 PIK3CG OSBPL3 CAPZA2	3.17e-04	441	47	5	12853948
Pubmed	Sox17-dependent gene expression and early heart and gut development in Sox17-deficient mouse embryos.	IDI1 MSMO1	4.84e-04	24	47	2	21305474
Pubmed	A large-scale candidate gene association study of age at menarche and age at natural menopause.	ROCK1 LIPE FTO GDF9	5.22e-04	275	47	4	20734064
Pubmed	A Golgi Lipid Signaling Pathway Controls Apical Golgi Distribution and Cell Polarity during Neurogenesis.	PITPNB PITPNA	5.26e-04	25	47	2	29587143
Pubmed	Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone.	LIPA LIPE PIK3CG	5.40e-04	117	47	3	18996102
Pubmed	Human chromosome 7: DNA sequence and biology.	GRM3 AVL9 PIK3CG OSBPL3 CAPZA2	7.68e-04	536	47	5	12690205
Pubmed	Bcl2L13 is a ceramide synthase inhibitor in glioblastoma.	IDI1 ETNK2	8.64e-04	32	47	2	24706805
Pubmed	Severe obesity is associated with novel single nucleotide polymorphisms of the ESR1 and PPARgamma locus in Han Chinese.	LIPE FTO	8.64e-04	32	47	2	19491387
Pubmed	DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice.	LIPA UNC93B1 MAN2B1	1.01e-03	145	47	3	21308776
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	PLA2R1 UNC93B1 NGLY1 MAN2B1 MSMO1 BCAP29 CLCC1	1.08e-03	1201	47	7	35696571
Pubmed	A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo.	IDI1 MSMO1	1.16e-03	37	47	2	26108225
Pubmed	Functional proteomics mapping of a human signaling pathway.	ROCK1 PITPNB MAN2B1 BRD1 SF3A2	1.19e-03	591	47	5	15231748
Pubmed	A long non-coding RNA specifically expressed in early embryos programs the metabolic balance in adult mice.	ELOVL3 LIPE	1.28e-03	39	47	2	33059001
Cytoband	7q22.3	BCAP29 PIK3CG	1.93e-04	20	47	2	7q22.3
GeneFamily	Phosphatidylinositol transfer proteins	PITPNB PITPNA	2.97e-05	6	26	2	1151
GeneFamily	Lipases\|Arylacetamide deacetylase family	LIPA LIPE	4.51e-04	22	26	2	464
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ROCK1 OSBPL3 KIF1B	3.12e-03	206	26	3	682
Coexpression	GSE4142_NAIVE_VS_MEMORY_BCELL_UP	KIAA0513 HPD OSBPL3 SLC22A2 KIF1B	2.29e-05	199	45	5	M6388
Coexpression	GSE2585_AIRE_KO_VS_WT_CD80_LOW_MTEC_DN	PEF1 LIPA IDI1 MSMO1 KIAA0513	2.35e-05	200	45	5	M6270
CoexpressionAtlas	FacebaseRNAseq_e10.5_Lateral Nasal Eminence_top-relative-expression-ranked_1000_k-means-cluster#3	EIF4E1B ROCK1 LIPA IDI1 CPLANE1 MSMO1 CLCC1	2.45e-06	291	45	7	Facebase_RNAseq_e10.5_Lateral Nasal Eminence_1000_K3
ToppCell	E16.5-samps-Myeloid-Fetal_macrophage-macrophage_-_intermediate_-_unactivated\|E16.5-samps / Age Group, Lineage, Cell class and subclass	SH2D2A UNC93B1 PIK3CG OSBPL3	1.74e-05	150	46	4	60fdd266aaca1b589b9a77465a4a7fad4921339a
ToppCell	droplet-Liver-Hepatocytes-24m-Epithelial-Hepatocyte_(Pericentral_and_Periportal)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ELOVL3 MSMO1 HPD ETNK2	1.93e-05	154	46	4	a5289000597068ee8d559f89bce7bce31f35dd57
ToppCell	droplet-Marrow-BM-1m-Myeloid-monocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LIPA UNC93B1 MAN2B1 PITPNA	2.77e-05	169	46	4	8066b4c02c97d00034802cff2b39799ef44cc904
ToppCell	droplet-Tongue-nan-24m-Epithelial-suprabasal_interpapillary\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IDI1 MSMO1 KIAA0513 ETNK2	2.97e-05	172	46	4	6ece9bb9f31685c918ca4cb7b82cf6ad1cad48af
ToppCell	facs-Skin-nan-24m-Lymphocytic-nan\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH2D2A SACS HPD PIK3CG	3.11e-05	174	46	4	6863222bec844f40c0c80f5c82a8ff51d1a56d0a
ToppCell	facs-Skin-nan-24m-Lymphocytic-T_cell\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH2D2A SACS HPD PIK3CG	3.11e-05	174	46	4	d570eab215f8287362084e37f35672e20aa0f7a2
ToppCell	facs-Skin-nan-24m-Lymphocytic\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SH2D2A SACS HPD PIK3CG	3.11e-05	174	46	4	5739c1b8d643ad360ef32049832d749c530ca603
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.Cyp26b1_(SNc/VTA)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	GDF5 ELOVL3 TGM6	3.45e-05	61	46	3	f41f1e770a5672f32cc5ccec3e33902c40f3fb1b
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th-Inhibitory_Neuron.Th.Cyp26b1_(SNc/VTA)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	GDF5 ELOVL3 TGM6	3.45e-05	61	46	3	b3f34ed4433aa8a8a9dea9e47fb98620b4e80a6c
ToppCell	droplet-Marrow-nan-24m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C21orf140 GPATCH4 BCAP29 ABCB8	4.11e-05	187	46	4	f491ec986dd44e2dabdf4a75c3101e3b6c921872
ToppCell	droplet-Marrow-nan-24m-Myeloid-Cd4_positive_Macrophages\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C21orf140 GPATCH4 BCAP29 ABCB8	4.11e-05	187	46	4	96dc5dc4dbc1b33c2e66666e9027cfbf7972090b
ToppCell	droplet-Tongue-TONGUE-1m-Epithelial-suprabasal_interpapillary\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IDI1 MSMO1 KIAA0513 ETNK2	4.56e-05	192	46	4	44cb225392c8d07150955ecf203fbdf6021c9790
ToppCell	368C-Fibroblasts-Fibroblast-I\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	GPATCH4 IDI1 MSMO1 ST6GALNAC5	5.04e-05	197	46	4	a3d5225b2b0dd5199f3c3f86713a05d48f1be8f4
ToppCell	368C-Fibroblasts-Fibroblast-I-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	GPATCH4 IDI1 MSMO1 ST6GALNAC5	5.04e-05	197	46	4	d7a10eca2d810ab87dea570676f0b7041f99f017
Drug	15-ketosteryl oleate	LIPA LIPE	1.14e-05	3	45	2	CID006444142
Drug	6-pyrenylhexanoic acid	LIPA LIPE	1.14e-05	3	45	2	CID000146248
Disease	grip strength measurement	GDF5 FTO GRM3 DNAH10 OSBPL3 KIF1B	1.47e-05	350	45	6	EFO_0006941
Disease	base metabolic rate measurement	GDF5 FTO	4.25e-04	20	45	2	EFO_0007777
Disease	abdominal:gluteofemoral adipose tissue ratio measurement	FTO DNAH10	8.99e-04	29	45	2	EFO_0803320

Protein segments in the cluster

Peptide	Gene	Start	Entry
WSSLKWFIINNRNEF	C21orf140	186	B9A014
LFLVLFFDNKRSWQW	BRD1	986	O95696
HRNPWFRDFWEQKFQ	GRM3	346	Q14832
FSFNVWGKIATFWNK	BCAP29	36	Q9UHQ4
FTNFHRQLFCWLDKW	PITPNA	221	Q00169
WHTLRFWNAAFFDAV	KIAA0513	301	O60268
WENQWKCFKVLLFNH	MSMO1	91	Q15800
WEVFDIWKLFRNFKN	GDF5	291	P43026
WFKEEFFHWVNNVLC	NGLY1	236	Q96IV0
HNEVEFEWLRQFWFQ	FTO	371	Q9C0B1
QHEFELAQWAFRKWK	KIF1B	741	O60333
LAQWAFRKWKSHQFT	KIF1B	746	O60333
WFFKNDRSRAWQDNL	EIF4E1B	71	A6NMX2
HFFWALWALIQNQYS	ETNK2	341	Q9NVF9
PAKEFTNHWWNELFN	GPATCH4	56	Q5T3I0
FSALWKFIQQWKNLF	PEF1	176	Q9UBV8
FTNFHRQLFCWIDKW	PITPNB	221	P48739
AATFLFKWWDNLNHL	IDI1	201	Q13907
SGFQKNWSWNSFFKI	CPLANE1	736	Q9H799
NWSWNSFFKIHPQVV	CPLANE1	741	Q9H799
QKVASWQAHQFEAWI	DPH7	186	Q9BTV6
NFIDNSTVKFWSWVF	ELOVL3	106	Q9HB03
FVTAWKNTHNYRVWN	AVL9	536	Q8NBF6
NKWQSFLRQQYDWSH	HEATR4	231	Q86WZ0
IAFFSRWWHQQTNAT	MAN2B1	121	O00754
HDFRLSFSQLKWDNW	GDF9	356	O60383
DFHFDNKRNQWVPWS	DNAH10	2396	Q8IVF4
FRWRFYLHETWTQGN	ERVFC1	31	P60507
HWRWLQFTVSLPNFF	SLC22A2	261	O15244
DNFASESWLKNAWHF	SACS	3236	Q9NZJ4
TQNLDVHFWKAFWNI	LIPE	531	Q05469
ESRNFVFWQDVRWKN	OSBPL3	641	Q9H4L5
HVVGSRFNWKLFWQF	ABCB8	126	Q9NUT2
ASEWYLKNLQFHRFW	HPD	196	P32754
QAETRAWFQKTQAHW	SH2D2A	71	Q9NP31
LFFNFTTRWNWLKLD	SEL1L2	646	Q5TEA6
SLWGQFWSAHQRFFK	SBNO2	531	Q9Y2G9
NWARTFNIHFFQPDW	ST6GALNAC5	306	Q9BVH7
LLHSKFNWTEERQFW	PLA2R1	721	Q13018
FNWTEERQFWIGFNK	PLA2R1	726	Q13018
WTHWNRETKQFFLQF	SF3A2	196	Q15428
QFTWAQWFETQHINM	RNASE2	31	P10153
HQFQAKNFWNGRWRS	CAPZA2	161	P47755
NFKFHDFETWKWRFE	CLCC1	161	Q96S66
RDKGWTVQFNWFLHL	PIK3CG	1076	P48736
RQDFIFTIYHWWQAV	UNC93B1	466	Q9H1C4
LHWAAFRNATKQWVQ	TTC41P	641	Q6P2S7
EIKRHLFFKNDQWAW	ROCK1	331	Q13464
NFHVWNESWFARQDL	TGM6	331	O95932
WSQAVKFQKFQAFDW	LIPA	296	P38571