Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	CCZ1B IQSEC3 RAP1GDS1 OBSCN RGP1 ARHGEF15 CCZ1 DENND4B DOCK7	1.42e-05	231	124	9	GO:0005085
Domain	ARM-type_fold	USP34 RAP1GDS1 XPO4 UNC45A HUWE1 JUP THADA AP2A1 PELP1 MTOR XPO6 ULK4 HECTD1 HTT	5.80e-08	339	124	14	IPR016024
Domain	ARM-like	RAP1GDS1 XPO4 UNC45A HUWE1 JUP AP2A1 PELP1 MTOR XPO6 ULK4 HECTD1 HTT	2.47e-07	270	124	12	IPR011989
Domain	-	RAP1GDS1 XPO4 UNC45A JUP AP2A1 MTOR XPO6 ULK4 HECTD1 HTT	2.30e-06	222	124	10	1.25.10.10
Domain	PRR14	PRR14 PRR14L	4.37e-05	2	124	2	IPR026320
Domain	DUF1712	CCZ1B CCZ1	4.37e-05	2	124	2	PF08217
Domain	Tantalus-like	PRR14 PRR14L	4.37e-05	2	124	2	IPR028149
Domain	DUF1712_fun	CCZ1B CCZ1	4.37e-05	2	124	2	IPR013176
Domain	Tantalus	PRR14 PRR14L	4.37e-05	2	124	2	PF15386
Domain	Pentatricopeptide_repeat	DENND4B GNAS HTT	4.59e-04	23	124	3	IPR002885
Domain	HECT	HECW1 HUWE1 HECTD1	7.44e-04	27	124	3	PF00632
Domain	HECTc	HECW1 HUWE1 HECTD1	7.44e-04	27	124	3	SM00119
Domain	HECT_dom	HECW1 HUWE1 HECTD1	7.44e-04	27	124	3	IPR000569
Domain	HECT	HECW1 HUWE1 HECTD1	7.44e-04	27	124	3	PS50237
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PITPNM2 USP34 SPRED2 CTC1 MFHAS1 PPRC1 OBSCN SREBF1 HIP1R FBXL12 HUWE1 BIRC6 RYR1 TRAK1 TRIM7 THADA KANSL1 AP2A1 MTOR XPO6 ULK4 CACNA1H HECTD1 HTT	3.22e-12	1105	130	24	35748872
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	RPF1 USP34 CCZ1B PRAMEF33 PRAMEF10 CTC1 PPRC1 OBSCN BAZ1B HUWE1 SLC38A2 PHKB JUP CCZ1 OSBPL11 TFB2M GOLGB1	6.51e-07	1084	130	17	11544199
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	ITPRID2 HUWE1 THOC6 PHKB JUP AP2A1 MTOR DOCK7 TFB2M HECTD1	2.83e-06	400	130	10	35013556
Pubmed	Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord.	PHRF1 HIP1R RNF157 CACNA1H	3.06e-06	27	130	4	19026994
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	IQSEC3 PPRC1 RNF157 TRAK1 PLEKHH1 KANSL1 ACOT11 DENND4B DOCK7 CACNA1H	3.30e-06	407	130	10	12693553
Pubmed	Inflammation-dependent overexpression of c-Myc enhances CRL4DCAF4 E3 ligase activity and promotes ubiquitination of ST7 in colitis-associated cancer.	USP34 CTC1 BCL3 AP2A1 DOCK7 PRR14L DCAF11 GOLGB1	5.96e-06	257	130	8	30945288
Pubmed	Two new cataract loci, Ccw and To3, and further mapping of the Npp and Opj cataracts in the mouse.	CRYGS C19orf84 DOCK7	8.24e-06	11	130	3	8812411
Pubmed	Elevated glucose represses lysosomal and mTOR-related genes in renal epithelial cells composed of progenitor CD133+ cells.	PROM1 MTOR	1.39e-05	2	130	2	33764985
Pubmed	WAVE2 suppresses mTOR activation to maintain T cell homeostasis and prevent autoimmunity.	MTOR WASF2	1.39e-05	2	130	2	33766857
Pubmed	[Expression and prognosis effect of methylation-regulated SLIT3 and SPARCL1 genes in smoking-related lung adenocarcinoma].	SLIT3 SPARCL1	1.39e-05	2	130	2	31154721
Pubmed	Inhibition of mTOR signaling reduces PELP1-mediated tumor growth and therapy resistance.	PELP1 MTOR	1.39e-05	2	130	2	24688046
Pubmed	Mechanism of the very efficient quenching of tryptophan fluorescence in human gamma D- and gamma S-crystallins: the gamma-crystallin fold may have evolved to protect tryptophan residues from ultraviolet photodamage.	CRYGD CRYGS	1.39e-05	2	130	2	19358562
Pubmed	Senolytics prevent caveolar CaV 3.2-RyR axis malfunction in old vascular smooth muscle.	RYR1 CACNA1H	1.39e-05	2	130	2	37837625
Pubmed	mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets.	BCL3 MTOR	1.39e-05	2	130	2	17110454
Pubmed	Folding and stability of the isolated Greek key domains of the long-lived human lens proteins gammaD-crystallin and gammaS-crystallin.	CRYGD CRYGS	1.39e-05	2	130	2	17905830
Pubmed	Kinetic Stability of Long-Lived Human Lens γ-Crystallins and Their Isolated Double Greek Key Domains.	CRYGD CRYGS	1.39e-05	2	130	2	31266635
Pubmed	Regulation of SREBP1c expression by mTOR signaling in hepatocytes.	SREBF1 MTOR	1.39e-05	2	130	2	20847591
Pubmed	Insulin-induced de novo lipid synthesis occurs mainly via mTOR-dependent regulation of proteostasis of SREBP-1c.	SREBF1 MTOR	1.39e-05	2	130	2	31541353
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	RPF1 BAZ1B ITPRID2 HUWE1 PELP1 DOCK7 PLRG1 DDX28	3.75e-05	332	130	8	25693804
Pubmed	HIP12 is a non-proapoptotic member of a gene family including HIP1, an interacting protein with huntingtin.	HIP1R HTT	4.15e-05	3	130	2	11063258
Pubmed	PI3KC3 complex subunit NRBF2 is required for apoptotic cell clearance to restrict intestinal inflammation.	CCZ1B CCZ1	4.15e-05	3	130	2	32160108
Pubmed	USP22 exerts tumor-suppressive functions in colorectal cancer by decreasing mTOR activity.	USP22 MTOR	4.15e-05	3	130	2	31527800
Pubmed	The cancer stem cell marker CD133 interacts with plakoglobin and controls desmoglein-2 protein levels.	PROM1 JUP	4.15e-05	3	130	2	23326490
Pubmed	Mutant huntingtin interacts with the sterol regulatory element-binding proteins and impairs their nuclear import.	SREBF1 HTT	4.15e-05	3	130	2	31875875
Pubmed	Combination of blockade of endothelin signalling and compensation of IGF1 expression protects the retina from degeneration.	PROM1 MTOR	4.15e-05	3	130	2	38252153
Pubmed	SREBF1 Activity Is Regulated by an AR/mTOR Nuclear Axis in Prostate Cancer.	SREBF1 MTOR	4.15e-05	3	130	2	29784665
Pubmed	mTOR Driven Gene Transcription Is Required for Cholesterol Production in Neurons of the Developing Cerebral Cortex.	SREBF1 MTOR	4.15e-05	3	130	2	34204880
Pubmed	THADA, SDHAF4, and MACF1 Gene Polymorphisms and Placental Expression in Women with Gestational Diabetes.	THADA SDHAF4	4.15e-05	3	130	2	36672824
Pubmed	mTOR direct crosstalk with STAT5 promotes de novo lipid synthesis and induces hepatocellular carcinoma.	SREBF1 MTOR	4.15e-05	3	130	2	31409773
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	PITPNM2 KCNH8 OBSCN SLITRK3 HUWE1 PPM1K ZP3 OPRL1 PLEKHH1 PHKB THADA ASTN2 CACNA1H GNAS HECTD1 GOLGB1 HTT	4.18e-05	1489	130	17	28611215
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	CCZ1B HIP1R UNC45A HUWE1 KANSL1 CCZ1 XPO6 GNAS PLRG1 GOLGB1	7.05e-05	582	130	10	20467437
Pubmed	Identification of host proteins required for HIV infection through a functional genomic screen.	LNX2 HIP1R HUWE1 RGP1 KDM4D PIGH LRIF1	7.72e-05	272	130	7	18187620
Pubmed	Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators.	PPRC1 TFB2M	8.28e-05	4	130	2	15684387
Pubmed	SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes.	PPRC1 SREBF1	8.28e-05	4	130	2	14722127
Pubmed	Recombinant human ZP3-induced sperm acrosome reaction: evidence for the involvement of T- and L-type voltage-gated calcium channels.	ZP3 CACNA1H	8.28e-05	4	130	2	20394732
Pubmed	Mutation analysis of 12 genes in Chinese families with congenital cataracts.	CRYGD CRYGS	8.28e-05	4	130	2	21866213
Pubmed	A hepatic amino acid/mTOR/S6K-dependent signalling pathway modulates systemic lipid metabolism via neuronal signals.	SLC38A2 MTOR	8.28e-05	4	130	2	26268630
Pubmed	Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease.	MTOR HTT	8.28e-05	4	130	2	25351248
Pubmed	Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells.	CCZ1B CCZ1	8.28e-05	4	130	2	20305638
Pubmed	MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632.	JUP MTOR	8.28e-05	4	130	2	14579029
Pubmed	Partially folded aggregation intermediates of human gammaD-, gammaC-, and gammaS-crystallin are recognized and bound by human alphaB-crystallin chaperone.	CRYGD CRYGS	8.28e-05	4	130	2	20621668
Pubmed	HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease.	MTOR WASF2	8.28e-05	4	130	2	32647003
Pubmed	Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms.	C19orf84 SIGLEC11 KLK2	9.75e-05	24	130	3	15331780
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	ITPRID2 UNC45A PHKB MTOR DOCK7 HECTD1	1.17e-04	202	130	6	33005030
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	HECW1 HUWE1 HECTD1	1.25e-04	26	130	3	26949039
Pubmed	Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development.	SPARCL1 TAL1	1.38e-04	5	130	2	17962413
Pubmed	The crystallins: genes, proteins and diseases.	CRYGD CRYGS	1.38e-04	5	130	2	9426193
Pubmed	Activity-Based Probes for HECT E3 Ubiquitin Ligases.	HUWE1 HECTD1	1.38e-04	5	130	2	28425671
Pubmed	Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c.	SREBF1 MTOR	1.38e-04	5	130	2	22521878
Pubmed	Structure of the crystallins.	CRYGD CRYGS	1.38e-04	5	130	2	10627816
Pubmed	Novel frem1-related mouse phenotypes and evidence of genetic interactions with gata4 and slit3.	FREM1 SLIT3	1.38e-04	5	130	2	23536828
Pubmed	Activation of a metabolic gene regulatory network downstream of mTOR complex 1.	SREBF1 MTOR	1.38e-04	5	130	2	20670887
Pubmed	Genetic mapping of 40 cDNA clones on the mouse genome by PCR.	ZP3 CRYGD AP2A1 KLK2	1.49e-04	71	130	4	8043949
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PITPNM2 USP34 PHRF1 HIP1R XPO4 RGP1 SLC38A2 SLIT3 FBXO41	1.76e-04	529	130	9	14621295
Pubmed	Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.	BIRC6 PHKB PELP1 PRR14L GNAS	1.82e-04	139	130	5	25476789
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	USP34 UNC45A HUWE1 TRIM24 BIRC6 JUP DOCK7 GOLGB1	1.85e-04	418	130	8	34709266
Pubmed	Human gamma-crystallin genes. A gene family on its way to extinction.	CRYGD CRYGS	2.06e-04	6	130	2	2258929
Pubmed	Gamma-crystallins of the human eye lens: expression analysis of five members of the gene family.	CRYGD CRYGS	2.06e-04	6	130	2	3670288
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	MYO1G USP34 SREBF1 BAZ1B TRIM24 GNAS HECTD1	2.18e-04	322	130	7	26514267
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	USP34 USP22 MTOR MINDY4 USP27X	2.36e-04	147	130	5	29576527
Pubmed	Human and mouse proteases: a comparative genomic approach.	USP34 USP22 FREM1 USP27X	2.48e-04	81	130	4	12838346
Pubmed	The E3 ubiquitin ligases, HUWE1 and NEDD4-1, are involved in the post-translational regulation of the ABCG1 and ABCG4 lipid transporters.	HUWE1 JUP HECTD1	2.56e-04	33	130	3	26296893
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	IQSEC3 HECW1 HUWE1 AP2A1 PELP1 MTOR WASF2 NCAN DOCK7 FBXO41 GOLGB1 FERMT3	2.75e-04	963	130	12	28671696
Pubmed	Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.	BAZ1B NCAN DOCK7	2.81e-04	34	130	3	19060911
Pubmed	A comparison of the dominant cataract and recessive specific-locus mutation rates induced by treatment of male mice with ethylnitrosourea.	CRYGS C19orf84	2.88e-04	7	130	2	6877261
Pubmed	Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila.	KANSL1 MTOR	2.88e-04	7	130	2	16543150
Pubmed	Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.	FBXL12 HUWE1 FBXL18 FBXO41	2.99e-04	85	130	4	19028597
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	MYO1G RPF1 BAZ1B THOC6 AP2A1 LRIF1 FERMT3	3.03e-04	340	130	7	29478914
Pubmed	Two quantitative trait loci affecting progressive hearing loss in 101/H mice.	PCDH15 CACNA1H	3.83e-04	8	130	2	16897347
Pubmed	WSTF acetylation by MOF promotes WSTF activities and oncogenic functions.	BAZ1B KANSL1	3.83e-04	8	130	2	32518374
Pubmed	Functional proteomics mapping of a human signaling pathway.	UNC45A HUWE1 TRAK1 JUP KANSL1 AP2A1 PELP1 SPARCL1 GOLGB1	3.97e-04	591	130	9	15231748
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	USP22 KBTBD6 UNC45A HUWE1 JUP DOCK7 OSBPL11 ABCC12 DCAF11 USP27X HECTD1 PLRG1	4.03e-04	1005	130	12	19615732
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	USP22 ITPRID2 UNC45A TRAK1 SLC38A2 JUP MTOR DOCK7 GNAS HECTD1 GOLGB1	4.04e-04	861	130	11	36931259
Pubmed	Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses.	LNX2 RGP1 KRTAP26-1	4.23e-04	39	130	3	22458338
Pubmed	K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors.	CCZ1B NSUN4 RAP1GDS1 HUWE1 BIRC6 ACTL8 AP2A1 ASB3 DDX28	4.64e-04	604	130	9	38803224
Pubmed	Human variation in alcohol response is influenced by variation in neuronal signaling genes.	DDO GUCY2D PCDH15 CACNA1H GNAS	4.73e-04	171	130	5	20201926
Pubmed	A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus.	HECW1 SPARCL1	4.91e-04	9	130	2	24121790
Pubmed	Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens.	CRYGD CRYGS	4.91e-04	9	130	2	8999933
Pubmed	mTORC1 Phosphorylates Acetyltransferase p300 to Regulate Autophagy and Lipogenesis.	SREBF1 MTOR	4.91e-04	9	130	2	29033323
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	PPRC1 SREBF1 BAZ1B UNC45A TRIM24 ARHGEF15 ULK4 TFB2M PLRG1 GOLGB1	5.58e-04	754	130	10	35906200
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	RPF1 NSUN4 BAZ1B BIRC6 THOC6 AP2A1 PELP1 HECTD1 PLRG1 DDX28	5.87e-04	759	130	10	35915203
Pubmed	A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints.	USP34 HUWE1	6.12e-04	10	130	2	17478428
Pubmed	Formation of neurodegenerative aggresome and death-inducing signaling complex in maternal diabetes-induced neural tube defects.	MTOR HTT	6.12e-04	10	130	2	28396396
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	XPO4 THADA AP2A1 MTOR XPO6	6.43e-04	183	130	5	23956138
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	PITPNM2 IQSEC3 AP2A1 MTOR NCAN GNAS	6.81e-04	281	130	6	28706196
Pubmed	NEDL2 is an essential regulator of enteric neural development and GDNF/Ret signaling.	HECW1 MTOR	7.46e-04	11	130	2	25555806
Pubmed	Disruption of Trkb-mediated signaling induces disassembly of postsynaptic receptor clusters at neuromuscular junctions.	CRYGD CRYGS	7.46e-04	11	130	2	10595510
Pubmed	Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease.	MTOR HTT	7.46e-04	11	130	2	32093570
Pubmed	Mapping of four mouse genes encoding eye lens-specific structural, gap junction, and integral membrane proteins: Cryba1 (crystallin beta A3/A1), Crybb2 (crystallin beta B2), Gja8 (MP70), and Lim2 (MP19).	C19orf84 KLK2	7.46e-04	11	130	2	8666393
Pubmed	Shotgun identification of protein modifications from protein complexes and lens tissue.	CRYGD CRYGS	7.46e-04	11	130	2	12060738
Pubmed	Mapping of six dominant cataract genes in the mouse.	CRYGD CRYGS	7.46e-04	11	130	2	8034315
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	USP34 C14orf93 HUWE1 TRIM24 PCDH15 TFB2M DDX28	7.49e-04	396	130	7	26687479
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	USP34 PHRF1 BAZ1B HUWE1 BIRC6 PELP1 MTOR DOCK7 HECTD1	8.07e-04	653	130	9	22586326
Pubmed	Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC.	SPRED2 USP22 XPO4 PIGH WASF2 NRK	8.46e-04	293	130	6	31741433
Pubmed	Mapping the Hrc gene to proximal mouse chromosome 7: delineation of a conserved linkage group with human 19q.	RYR1 KLK2	8.93e-04	12	130	2	8288260
Pubmed	Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion.	SREBF1 MTOR	8.93e-04	12	130	2	27307439
Pubmed	Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan.	MFHAS1 PPM1K	1.05e-03	13	130	2	18846501
Pubmed	Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation.	NSUN4 KBTBD6 CTC1 AP2A1	1.10e-03	120	130	4	27565346
Pubmed	Common variants at 30 loci contribute to polygenic dyslipidemia.	BAZ1B NCAN DOCK7	1.10e-03	54	130	3	19060906
Pubmed	Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells.	MTOR HEY2	1.23e-03	14	130	2	21349854
Interaction	TOP3B interactions	PITPNM2 USP34 SPRED2 CTC1 MFHAS1 PPRC1 OBSCN SREBF1 HIP1R FBXL12 UNC45A HUWE1 BIRC6 RYR1 TRAK1 TRIM7 THADA KANSL1 AP2A1 PELP1 MTOR XPO6 ULK4 CACNA1H GNAS HECTD1 DDX28 HTT	5.97e-08	1470	124	28	int:TOP3B
Interaction	TACSTD2 interactions	USP22 HIP1R XPO4 THADA MTOR XPO6 USP27X	1.51e-05	129	124	7	int:TACSTD2
GeneFamily	Exportins	XPO4 XPO6	5.06e-04	7	90	2	547
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	RAP1GDS1 JUP THADA	1.27e-03	43	90	3	409
GeneFamily	Beta-gamma crystallins	CRYGD CRYGS	2.47e-03	15	90	2	1359
GeneFamily	Ring finger proteins	RNF32 LNX2 PHRF1 TRIM24 RNF157 TRIM7	2.51e-03	275	90	6	58
GeneFamily	Ubiquitin specific peptidases	USP34 USP22 USP27X	2.73e-03	56	90	3	366
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PITPNM2 USP34 USP22 ITPRID2 BIRC6 ARHGEF15 SPARCL1	2.06e-06	200	130	7	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
Disease	Endocrine System Diseases	MTOR GNAS	5.16e-05	3	123	2	C0014130
Disease	unipolar depression, environmental factor	ASTN2 RFLNA	2.56e-04	6	123	2	EFO_0000469, EFO_0003761
Disease	stromal membrane-associated protein 1 measurement	UNC45A SDHAF4	2.56e-04	6	123	2	EFO_0802094
Disease	very low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio	PITPNM2 MFHAS1 BCL3 DOCK7 RFLNA HTT	3.46e-04	222	123	6	EFO_0008317, EFO_0020943
Disease	age at diagnosis, osteoarthritis	KANSL1 RFLNA	3.57e-04	7	123	2	EFO_0004918, MONDO_0005178
Disease	bipolar II disorder	NCAN SLIT3	4.75e-04	8	123	2	EFO_0009964
Disease	glioblastoma (implicated_via_orthology)	USP22 USP27X	6.09e-04	9	123	2	DOID:3068 (implicated_via_orthology)
Disease	fish oil supplement exposure measurement, triglyceride measurement	BAZ1B NCAN	7.59e-04	10	123	2	EFO_0004530, EFO_0600007
Disease	body weight	HUWE1 RGP1 TRIM24 SPATA31C1 SLC38A2 MTOR ASB3 SLIT3 PCDH15 HEY2 ULK4 ASTN2 GNAS TAL1	7.93e-04	1261	123	14	EFO_0004338
Disease	uric acid measurement	USP34 BAZ1B PPM1K BIRC6 PLEKHH1 GUCY2D CST6 MINDY4 GNAS	1.06e-03	610	123	9	EFO_0004761
Disease	congenital diaphragmatic hernia (implicated_via_orthology)	FREM1 SLIT3	1.11e-03	12	123	2	DOID:3827 (implicated_via_orthology)
Disease	Hermansky-Pudlak syndrome (implicated_via_orthology)	CCZ1B CCZ1	1.52e-03	14	123	2	DOID:3753 (implicated_via_orthology)
Disease	body surface area	RGP1 SPATA31C1 MTOR SLIT3 HEY2 GPR156 ULK4 ASTN2 GNAS	1.53e-03	643	123	9	EFO_0022196
Disease	low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	MFHAS1 OPRL1 DOCK7 RFLNA HTT	1.54e-03	200	123	5	EFO_0004611, EFO_0020945
Disease	age at menopause	PITPNM2 CCZ1B CCNJ BIRC6 CCZ1 LRIF1	1.71e-03	302	123	6	EFO_0004704
Disease	apolipoprotein B measurement	BAZ1B BCL3 THADA TIRAP NCAN DOCK7 RFLNA PLRG1 HTT	1.88e-03	663	123	9	EFO_0004615
Disease	mean reticulocyte volume	SPRED2 PPRC1 OPRL1 THADA KANSL1 MTOR ASB3 RFLNA TAL1 GOLGB1	1.93e-03	799	123	10	EFO_0010701
Disease	fatty acid measurement	MFHAS1 BAZ1B KANSL1 NCAN DOCK7 RFLNA FERMT3	2.40e-03	436	123	7	EFO_0005110
Disease	esophageal adenocarcinoma	HECW1 SPARCL1	2.52e-03	18	123	2	EFO_0000478
Disease	Intellectual Disability	IQSEC3 KANSL1 MTOR TFB2M GNAS USP27X HTT	2.75e-03	447	123	7	C3714756
Disease	polycystic kidney disease (biomarker_via_orthology)	MTOR GNAS	2.81e-03	19	123	2	DOID:0080322 (biomarker_via_orthology)
Disease	gastric ulcer	JUP GNAS	3.44e-03	21	123	2	EFO_0009454
Disease	mean platelet volume	PITPNM2 LNX2 HIP1R DDO FBXL18 DOCK7 GNAS TAL1 SDHAF4 HTT FERMT3	3.64e-03	1020	123	11	EFO_0004584
Disease	Schizophrenia	SREBF1 DDO TRAK1 SLC38A2 MTOR NCAN SLIT3 ULK4 ASTN2 GNAS	3.93e-03	883	123	10	C0036341
Disease	response to clopidogrel, cardiovascular event measurement	PPM1K FREM1	4.12e-03	23	123	2	EFO_0006919, GO_1903493

Protein segments in the cluster

Peptide	Gene	Start	Entry
LRVLLPALSHCSQLT	PRAMEF33	366	A0A0G2JMD5
EEATALPLRRLCHLS	GNAS	151	P84996
TLSRAIHTRPCLDSV	ADAD2	436	Q8NCV1
SAVCLRLHRPRDAST	BIRC6	3276	Q9NR09
LILVCLSALSHHSPR	BIRC6	4246	Q9NR09
TLLPRLECSGTISAH	LINC00269	76	Q8N2A0
FLTHVNPRLRLSCLS	CTC1	1186	Q2NKJ3
ESCEISLRPLLVSHV	ACTL8	281	Q9H568
IPLTLHSVSELVRLC	BAZ1B	681	Q9UIG0
AACVASSRIILRLSP	CCNJ	196	Q5T5M9
LTLRTSKEPVSRHLC	AP2A1	956	O95782
TVRHLIASSCPGLSD	CD300LD-AS1	216	Q96MU5
TIAASRLCRAHPTLK	ACOT11	251	Q8WXI4
TVPIRLDTLSCLLHS	C19orf84	56	I3L1E1
LATLLSRVRSSPHIS	ARHGEF15	476	O94989
SRVRSSPHISDLCDV	ARHGEF15	481	O94989
RCTVATSRLLLHSLF	LVRN	136	Q6Q4G3
ILRRLERVSSHCSSL	ASTN2	1266	O75129
LLLAAARRTLSPVHT	NWD1	506	Q149M9
RLLQDDRRVTPTCHS	PPM1K	26	Q8N3J5
SRPLQRLSCSDLFIH	OR9K2	206	Q8NGE7
SDPLRVRLVSHLSTC	HEY2	146	Q9UBP5
LRPRSLQCVSLHLLS	KLK2	166	P20151
CSVVRPLARSHVALL	GPR6	216	P46095
LHLACGSERLTLRSP	LRP10	76	Q7Z4F1
RVCLTRIPDHLTSGE	LRIF1	581	Q5T3J3
AHLPDSLSCLSRLRT	MFHAS1	171	Q9Y4C4
LTRHCPSEGSVLDSL	GUCY2D	311	Q02846
PSSALSEVSLRLLCH	NAA60	6	Q9H7X0
IREHASLTRTRTVPC	GAB3	461	Q8WWW8
TSLPRAHTCFNRLDL	HECW1	1566	Q76N89
ELTPCRRTLSVNHLT	KCNK2	376	O95069
LPSTLHSCHDIVLRR	LNX2	591	Q8N448
LHPTIDVLVTCSRDS	PLRG1	296	O43660
VLHTLIRCRFSPIHS	DCAF11	436	Q8TEB1
CTVSLDTARTRLPAH	FREM1	171	Q5H8C1
SSTIPSLLRGRHVVC	DDX28	156	Q9NUL7
RECSPTSSLERLCRH	PHRF1	1121	Q9P1Y6
RHLASEDTRCSTPEL	KANSL1	1011	Q7Z3B3
RCHTLVCSSLPRRSA	KDM4D	396	Q6B0I6
ALSHTPSVRRLSLLA	PITPNM2	861	Q9BZ72
SEALVTCAALTHPRV	PELP1	621	Q8IZL8
DPDTLHATLRLCLRL	HUWE1	1771	Q7Z6Z7
RPLCEHTRTLSTHSV	ITPRID2	856	P28290
TVLSVPHRRLVCCSR	IQSEC3	861	Q9UPP2
ITEPAVCALRHLTSR	JUP	451	P14923
RVLVDVPCTTDRHSL	NSUN4	251	Q96CB9
AARLVSECVHALRTP	DDO	321	Q99489
CDRTRHTLTIREVPA	OBSCN	661	Q5VST9
CVLHSSLSRRETPIC	PCDH15	1706	Q96QU1
IATVPSLTHLCRLEI	ASB3	456	Q9Y575
GLSDSVRSCRLIPHS	CRYGD	71	P07320
LHLRCTSSPDYLVSR	HIP1R	646	O75146
LCRGSPVVTHDLLRS	HECTD1	286	Q9ULT8
LLESTLRSSHLPSRV	HTT	2766	P42858
RLLRHCSSSIGTIRS	DOCK7	1556	Q96N67
SRLDSPRSRCLHLAS	LINC01599	126	Q8WXQ3
LSAAERVTHPARCTL	DYTN	216	A2CJ06
LNDRLSSCRAVHLPS	CRYGS	76	P22914
LRHSLGLTVSPCRTR	C14orf93	276	Q9H972
SVHPTLDFCRRLDSI	CCZ1	331	P86791
VIDHLRSLCSITDPA	RAP1GDS1	136	P52306
LLVRRLSCHVLSASV	GPAT2	441	Q6NUI2
SVHPTLDFCRRLDSI	CCZ1B	331	P86790
ILRISHCPNILTDRS	FBXO41	661	Q8TF61
TRVTGDHVDLTTCPL	CST6	101	Q15828
HSLRPDLLTSVCEAL	DENND4B	426	O75064
RRPLHDLCKTTITSS	GPR156	21	Q8NFN8
LRTSRHIPLTSIDLC	KRTAP26-1	16	Q6PEX3
SARLITRAHVECSPA	CRIPAK	186	Q8N1N5
RLEPSAHRLLVATVC	GPR146	226	Q96CH1
LACEHRSPTCLRALL	BCL3	211	P20749
SPSLSRLLCRQEAVH	CACNA1H	2006	O95180
ARSPLLCHSLRKTSS	SDHAF4	21	Q5VUM1
PISESLESVRLACIH	SPACA1	126	Q9HBV2
EPALRCLSLLHTLVA	RYR1	4641	P21817
CIAASREPLDHRTSS	PPRC1	1346	Q5VV67
SPLTCLAHTRTVTTL	KBTBD6	371	Q86V97
RQTLCSLLPRESRSH	PHKB	276	Q93100
IHSFPRSLCLVTSLE	LRRC30	221	A6NM36
AHRLLSLCTLSAPTR	PRR14L	1561	Q5THK1
RRIECLPTSGHLSSL	OSBPL11	236	Q9BXB4
AICHPIRALDVRTSS	OPRL1	151	P41146
EAARTCSRLLTPSIH	MTOR	621	P42345
CTHELLRLPTSSRCR	NRK	366	Q7Z2Y5
VILSCEDHLPTESRL	THADA	1686	Q6YHU6
LSDVRDTLILPCRHL	RNF157	281	Q96PX1
ESCLHTTRTSFSLPI	RGP1	291	Q92546
RLLHLPSRSELISST	RND1	206	Q92730
TAEARHRVPTTELCR	TAL1	81	P17542
RLRHLRSLSLPVCSV	FBXL18	411	Q96ME1
SLPSTLRTLELHSCE	FBXL12	121	Q9NXK8
ACRLSSAIIAAPRHL	NCAN	181	O14594
CLCREPLSRIHRTSS	PRR14	111	Q9BWN1
CRSPENLTHRDVRTI	SLITRK3	591	O94933
TSLRSSLNDPLCLVH	PROM1	296	O43490
LRRETHECSICLAPL	RNF32	286	Q9H0A6
RSATVIDHLRSLTPL	TFB2M	331	Q9H5Q4
LRDSTLLTPSHCDSV	SPATA31C1	241	P0DKV0
TLSCHILLRRKLTAP	ABCC12	361	Q96J65
PTRREHAEALLLASC	SREBF1	1081	P36956
FTTCRILHPSDELTR	TRAK1	671	Q9UPV9
ADRLLLTTPTHRFQC	SLIT3	891	O75094
ITTSDRPHGRTVRLC	RPF1	146	Q9H9Y2
LRHLLRARCDASPVT	TRIM24	386	O15164
HIPGITTLTDCLRRF	USP27X	256	A6NNY8
TTLTDCLRRFTRPEH	USP27X	261	A6NNY8
TLTDCLRRFTRPEHL	USP22	361	Q9UPT9
SPLSCGHLSRVRVAL	TRIM7	451	Q9C029
HCIPLLTSLLEERVT	XPO4	491	Q9C0E2
PSDAHRTRCLVLALA	MINDY4	486	Q4G0A6
IFPIRSSVTHLLCAS	SLC38A2	391	Q96QD8
RSTFRTTLHCSLGRP	RFLNA	176	Q6ZTI6
RVLTHSELAPLRASL	SPARCL1	606	Q14515
IHCLALRERSPEVLS	THOC6	171	Q86W42
LSCPRLSLRSLTAVT	PIGH	31	Q14442
LRVLLPALSHCSQLT	PRAMEF10	366	O60809
ISSPTSCEHRRIYTL	SPRED2	166	Q7Z698
AICRLLSIRHPEELS	FERMT3	126	Q86UX7
RLLSSHCTLVIHPTE	PLEKHH1	756	Q9ULM0
TGRARPICESLHSSL	TBC1D29P	81	Q9UFV1
RHLCRQTLPSVRSEL	WASF2	11	Q9Y6W5
ALSSSHCRVLLITPG	TIRAP	136	P58753
TLLIPETAVRHESCS	USP34	1661	Q70CQ2
SACHLLVSLATTVRP	XPO6	676	Q96QU8
ILVLTRRCRTASHPV	ZP3	406	P21754
SLRLVCVTHSSPPAR	SIGLEC11	386	Q96RL6
SPVLTSSCRELLSRV	UNC45A	656	Q9H3U1
TIIRLLDSPSTCIRA	ULK4	736	Q96C45
PDAARELRSCLLHLT	TTC31	406	Q49AM3
LRSLCHSRTRVPLLA	GOLGB1	3226	Q14789
LQFLRCISPHSDSTL	KCNH8	1006	Q96L42
TLEVRVSDCIPLSHR	MYO1G	971	B0I1T2
RRILSHGVTSFCPTL	AMDHD2	96	Q9Y303