Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ankyrin binding	SPTB SPTBN1	3.75e-04	23	25	2	GO:0030506
GeneOntologyCellularComponent	spectrin-associated cytoskeleton	SPTB SPTBN1	4.53e-05	9	24	2	GO:0014731
GeneOntologyCellularComponent	spectrin	SPTB SPTBN1	4.53e-05	9	24	2	GO:0008091
GeneOntologyCellularComponent	cytoplasmic side of plasma membrane	BIRC2 PTPN4 SPTB	1.20e-03	185	24	3	GO:0009898
GeneOntologyCellularComponent	cytoplasmic side of membrane	BIRC2 PTPN4 SPTB	2.24e-03	230	24	3	GO:0098562
Domain	Spectrin_bsu	SPTB SPTBN1	1.12e-05	4	26	2	IPR016343
Domain	Actinin_actin-bd_CS	SPTB SPTBN1	4.63e-04	23	26	2	IPR001589
Domain	ACTININ_2	SPTB SPTBN1	4.63e-04	23	26	2	PS00020
Domain	ACTININ_1	SPTB SPTBN1	4.63e-04	23	26	2	PS00019
Domain	Spectrin	SPTB SPTBN1	4.63e-04	23	26	2	PF00435
Domain	Spectrin_repeat	SPTB SPTBN1	7.39e-04	29	26	2	IPR002017
Domain	Spectrin/alpha-actinin	SPTB SPTBN1	9.01e-04	32	26	2	IPR018159
Domain	SPEC	SPTB SPTBN1	9.01e-04	32	26	2	SM00150
Domain	CH	SPTB SPTBN1	3.67e-03	65	26	2	SM00033
Domain	CH	SPTB SPTBN1	4.25e-03	70	26	2	PF00307
Domain	-	SPTB SPTBN1	4.37e-03	71	26	2	1.10.418.10
Domain	CH	SPTB SPTBN1	4.61e-03	73	26	2	PS50021
Domain	CH-domain	SPTB SPTBN1	4.86e-03	75	26	2	IPR001715
Pathway	WP_TGFBETA_RECEPTOR_SIGNALING_IN_SKELETAL_DYSPLASIAS	FBN1 ZFYVE9 ZNF423	5.43e-05	59	18	3	M39886
Pathway	REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS	SPTB SPTBN1	6.89e-05	10	18	2	MM15112
Pubmed	A new spectrin, beta IV, has a major truncated isoform that associates with promyelocytic leukemia protein nuclear bodies and the nuclear matrix.	SPTB SPTBN1	1.61e-06	3	26	2	11294830
Pubmed	PERK inhibits DNA replication during the Unfolded Protein Response via Claspin and Chk1.	CHEK1 EIF2AK3	1.61e-06	3	26	2	27375025
Pubmed	The complete amino acid sequence for brain beta spectrin (beta fodrin): relationship to globin sequences.	SPTB SPTBN1	1.61e-06	3	26	2	8479293
Pubmed	PERK-dependent regulation of IAP translation during ER stress.	BIRC2 EIF2AK3	1.61e-06	3	26	2	19029953
Pubmed	β spectrin-dependent and domain specific mechanisms for Na+ channel clustering.	SPTB SPTBN1	1.61e-06	3	26	2	32425157
Pubmed	Developmental expression of brain beta-spectrin isoform messenger RNAs.	SPTB SPTBN1	1.61e-06	3	26	2	1467942
Pubmed	The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation.	SPTB SPTBN1	3.22e-06	4	26	2	21566095
Pubmed	Spectrin alpha II and beta II isoforms interact with high affinity at the tetramerization site.	SPTB SPTBN1	3.22e-06	4	26	2	12820899
Pubmed	Remarkable homology among the internal repeats of erythroid and nonerythroid spectrin.	SPTB SPTBN1	3.22e-06	4	26	2	3862089
Pubmed	Apparent structural differences at the tetramerization region of erythroid and nonerythroid beta spectrin as discriminated by phage displayed scFvs.	SPTB SPTBN1	3.22e-06	4	26	2	21412925
Pubmed	Cell organization, growth, and neural and cardiac development require αII-spectrin.	SPTB SPTBN1	2.41e-05	10	26	2	22159418
Pubmed	Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin.	SPTB SPTBN1	2.94e-05	11	26	2	17607528
Pubmed	alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells.	SPTB SPTBN1	4.17e-05	13	26	2	18796539
Pubmed	Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.	SPTB SPTBN1	8.16e-05	18	26	2	12119179
Pubmed	Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice.	SPTB SPTBN1	1.01e-04	20	26	2	18723693
Pubmed	Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2.	SPTB SPTBN1	1.60e-04	25	26	2	8493579
Pubmed	TTF-1/NKX2-1 binds to DDB1 and confers replication stress resistance to lung adenocarcinomas.	SEH1L ZFHX3 CHEK1	1.98e-04	152	26	3	28192407
Pubmed	TRAF1 Coordinates Polyubiquitin Signaling to Enhance Epstein-Barr Virus LMP1-Mediated Growth and Survival Pathway Activation.	BIRC2 EIF2AK3	2.47e-04	31	26	2	25996949
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	BIRC2 FBN1 ZMYM4 ZNF423 SPTB SPTBN1	3.06e-04	1285	26	6	35914814
Pubmed	Cancer-associated exportin-6 upregulation inhibits the transcriptionally repressive and anticancer effects of nuclear profilin-1.	ZMYM4 SPTBN1	5.22e-04	45	26	2	33596420
Pubmed	METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.	SEH1L RANBP6 SPTBN1	6.72e-04	231	26	3	36597993
Cytoband	1p32.3	CZIB ZFYVE9	5.53e-04	61	26	2	1p32.3
Cytoband	Ensembl 112 genes in cytogenetic band chr11q22	BIRC2 DYNC2H1	1.69e-03	107	26	2	chr11q22
Cytoband	Ensembl 112 genes in cytogenetic band chr1p32	CZIB ZFYVE9	3.49e-03	155	26	2	chr1p32
Cytoband	Ensembl 112 genes in cytogenetic band chr1p34	ZMYM4 ERI3	1.20e-02	294	26	2	chr1p34
GeneFamily	EF-hand domain containing\|Spectrins	SPTB SPTBN1	1.54e-05	7	16	2	1113
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	SPTB SPTBN1	1.40e-02	206	16	2	682
Disease	spinocerebellar ataxia type 5 (implicated_via_orthology)	SPTB SPTBN1	4.47e-06	4	26	2	DOID:0050882 (implicated_via_orthology)
Disease	polybrominated biphenyl measurement, gestational serum measurement, fetal genotype effect measurement, polybrominated diphenyl ether measurement	ZFHX3 LOXHD1	4.09e-05	11	26	2	EFO_0007959, EFO_0007961, EFO_0007962, EFO_0007964
Disease	Disproportionate short stature	FBN1 DYNC2H1 EIF2AK3	4.25e-05	77	26	3	C0878659
Disease	intraocular pressure measurement	ZFHX3 FBN1 THSD7A DYNC2H1 SPTBN1	7.30e-05	509	26	5	EFO_0004695
Disease	insular cortex volume measurement	LOXHD1 THSD7A	1.87e-04	23	26	2	EFO_0010309
Disease	cervical cancer (is_marker_for)	BIRC2 ZFHX3	4.62e-04	36	26	2	DOID:4362 (is_marker_for)
Disease	behavior	ZFHX3 ZNF423	1.08e-03	55	26	2	GO_0007610
Disease	ovarian carcinoma	ZFHX3 THSD7A ZNF423	2.75e-03	321	26	3	EFO_0001075

Protein segments in the cluster

Peptide	Gene	Start	Entry
QWINLKKAYSFAMGC	ERI3	271	O43414
TCEKLGYQWKKSCMN	CHEK1	396	O14757
CRKENLKDWMNGRCT	EIF2AK3	891	Q9NZJ5
GCQNTMWVKRKYIAC	CPXCR1	166	Q8N123
FNMVNYRACKNLWKA	PTPN4	286	P29074
LQKLRWYCQMCQKQC	KIN	21	O60870
KYMLNCNCWLAKDRG	LOXHD1	1516	Q8IVV2
YNMTLCRNEWKKIFC	FFAR4	321	Q5NUL3
MLKECARNGDWLCLK	DYNC2H1	3766	Q8NCM8
KKMCCCSYNIGRAWN	FBN1	1716	P35555
KNGWAMCGKQRDCCV	DEFB126	46	Q9BYW3
CVRLWKANYMDNWKC	SEH1L	301	Q96EE3
RWYLKMKCGNCGEIS	CZIB	26	Q9NWV4
MKCGNCGEISDKWQY	CZIB	31	Q9NWV4
LKYCEALGLEKNWQM	THSD7A	1261	Q9UPZ6
MCIDAEGKLWVACYN	RGN	206	Q15493
WARMCKILGKDFQQY	RANBP6	616	O60518
KDALLLWCQMKTAGY	SPTBN1	176	Q01082
VKCFCCGLMLDNWKL	BIRC2	81	Q13490
LMWVCNKCAYKFQRK	VSTM5	166	A8MXK1
FCGMDPEQRKWQKYC	TNS4	651	Q8IZW8
KDALLLWCQMKTAGY	SPTB	176	P11277
LCLKGMFLKLNYWNT	SMCO2	121	A6NFE2
EKKMYRCTACNWDFR	ZNF423	746	Q2M1K9
KRWGNHCKMCSYCLQ	ZMYM4	766	Q5VZL5
NYVNRKCWCFTTKGM	ZFYVE9	956	O95405
WKAVMGDSYQCKLCR	ZFHX3	976	Q15911