Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	FOXO1 CDX4 NR5A2 SRF PLAGL2 PAX6 ONECUT1 MEIS1 MEIS2 NOTCH2 FOXF2	1.06e-07	560	50	11	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	FOXO1 CDX4 NR5A2 SRF PLAGL2 PAX6 ONECUT1 MEIS1 MEIS2 NOTCH2 FOXF2	1.18e-07	566	50	11	GO:0001216
GeneOntologyMolecularFunction	transcription factor binding	FOXO1 PCLO KAT6A NR5A2 SRF MED12L PAX6 MED13 MEIS2 NOTCH2 FOXF2	1.99e-06	753	50	11	GO:0008134
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ALX3 FOXO1 CDX4 TFAP2D NR5A2 SRF PLAGL2 PAX6 ONECUT1 CIC MEIS1 MEIS2 NOTCH2 FOXF2	6.13e-06	1412	50	14	GO:0000981
GeneOntologyMolecularFunction	chromatin binding	FOXO1 KAT6A NR5A2 SRF SMARCA2 PAX6 ONECUT1 CIC MEIS1	7.96e-05	739	50	9	GO:0003682
GeneOntologyMolecularFunction	copper ion transmembrane transporter activity	SLC11A2 SLC31A1	1.70e-04	8	50	2	GO:0005375
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ALX3 FOXO1 CDX4 TFAP2D NR5A2 SRF PAX6 ONECUT1 CIC MEIS1 MEIS2 FOXF2	1.98e-04	1459	50	12	GO:0000977
GeneOntologyMolecularFunction	transcription coregulator binding	FOXO1 PCLO NR5A2 PAX6	4.15e-04	140	50	4	GO:0001221
GeneOntologyMolecularFunction	transition metal ion binding	PAPPA2 RASGRP1 SLC11A2 SLC31A1 KAT6A NR5A2 HLTF PAPPA MMP15 LARGE1	6.24e-04	1189	50	10	GO:0046914
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	FOXO1 CDX4 NR5A2 SRF PAX6 ONECUT1 MEIS1 MEIS2 NOTCH2 FOXF2	1.04e-03	1271	50	10	GO:0000987
GeneOntologyMolecularFunction	zinc ion binding	PAPPA2 RASGRP1 SLC11A2 KAT6A NR5A2 HLTF PAPPA MMP15	1.55e-03	891	50	8	GO:0008270
GeneOntologyMolecularFunction	N-acyltransferase activity	NAT8L KAT6A ALAS1	2.13e-03	102	50	3	GO:0016410
GeneOntologyMolecularFunction	metalloendopeptidase activity	PAPPA2 PAPPA MMP15	3.38e-03	120	50	3	GO:0004222
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	FOXO1 CDX4 NR5A2 SRF PAX6 ONECUT1 MEIS1 MEIS2 FOXF2	3.39e-03	1244	50	9	GO:0000978
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	SMARCA2 HLTF	3.87e-03	37	50	2	GO:0140658
GeneOntologyBiologicalProcess	positive regulation of transcription by RNA polymerase II	FOXO1 CDX4 TFAP2D NR5A2 SRF MED12L SMARCA2 HLTF PLAGL2 PAX6 ONECUT1 MED13 MEIS1 MEIS2 NOTCH2 FOXF2	9.15e-08	1390	50	16	GO:0045944
GeneOntologyBiologicalProcess	vasculature development	FOXO1 CDX4 SLC31A1 SGCD KAT6A SRF SMARCA2 PAX6 MEIS1 NOTCH2 DNM2 LARGE1	2.51e-06	969	50	12	GO:0001944
GeneOntologyBiologicalProcess	hemopoiesis	RASGRP1 RC3H2 SLC11A2 PTPRZ1 KAT6A SRF SMARCA2 ALAS1 ONECUT1 MEIS1 MEIS2 NOTCH2 LARGE1	4.75e-06	1223	50	13	GO:0030097
GeneOntologyBiologicalProcess	myeloid cell development	SLC11A2 SRF ALAS1 MEIS1 NOTCH2	6.59e-06	109	50	5	GO:0061515
GeneOntologyBiologicalProcess	regulation of cell development	RASGRP1 RC3H2 PTPRZ1 KAT6A SRF SMARCA2 HLTF PAX6 MEIS1 MEIS2 PCM1 NOTCH2	8.78e-06	1095	50	12	GO:0060284
GeneOntologyBiologicalProcess	blood vessel development	FOXO1 CDX4 SLC31A1 SGCD KAT6A SRF PAX6 MEIS1 NOTCH2 DNM2 LARGE1	1.08e-05	929	50	11	GO:0001568
GeneOntologyBiologicalProcess	copper ion import across plasma membrane	SLC11A2 SLC31A1	1.73e-05	3	50	2	GO:0098705
GeneOntologyBiologicalProcess	plasma membrane copper ion transport	SLC11A2 SLC31A1	1.73e-05	3	50	2	GO:0015679
GeneOntologyBiologicalProcess	learning or memory	SLC11A2 PTPRZ1 SRF PAX6 CIC MEIS2 LARGE1	3.06e-05	373	50	7	GO:0007611
GeneOntologyBiologicalProcess	animal organ morphogenesis	ALX3 PAPPA2 CDX4 KAT6A NR5A2 SRF PAX6 MEIS1 MEIS2 NOTCH2 FOXF2 LARGE1	3.82e-05	1269	50	12	GO:0009887
GeneOntologyBiologicalProcess	behavior	SLC11A2 PTPRZ1 SRF ANKRD26 PAX6 CIC MEIS1 MEIS2 PCM1 LARGE1	4.58e-05	891	50	10	GO:0007610
GeneOntologyBiologicalProcess	myeloid cell differentiation	SLC11A2 KAT6A SRF ALAS1 MEIS1 MEIS2 NOTCH2 LARGE1	5.38e-05	558	50	8	GO:0030099
GeneOntologyBiologicalProcess	camera-type eye morphogenesis	PAX6 MEIS1 NOTCH2 FOXF2 LARGE1	5.79e-05	171	50	5	GO:0048593
GeneOntologyBiologicalProcess	cognition	SLC11A2 PTPRZ1 SRF PAX6 CIC MEIS2 LARGE1	6.78e-05	423	50	7	GO:0050890
GeneOntologyBiologicalProcess	negative regulation of DNA-templated transcription	RALGAPA1 FOXO1 CDX4 TLE5 KAT6A SRF SMARCA2 PAX6 CIC MEIS2 NOTCH2 FOXF2	9.81e-05	1399	50	12	GO:0045892
GeneOntologyBiologicalProcess	negative regulation of RNA biosynthetic process	RALGAPA1 FOXO1 CDX4 TLE5 KAT6A SRF SMARCA2 PAX6 CIC MEIS2 NOTCH2 FOXF2	1.08e-04	1413	50	12	GO:1902679
GeneOntologyBiologicalProcess	pancreas development	NR5A2 PAX6 ONECUT1 MEIS2	1.09e-04	102	50	4	GO:0031016
GeneOntologyBiologicalProcess	regulation of miRNA metabolic process	RC3H2 SRF PAX6 NOTCH2	1.13e-04	103	50	4	GO:2000628
GeneOntologyBiologicalProcess	circulatory system development	FOXO1 CDX4 SLC31A1 SGCD KAT6A SRF SMARCA2 PAX6 MEIS1 NOTCH2 DNM2 LARGE1	1.31e-04	1442	50	12	GO:0072359
GeneOntologyBiologicalProcess	eye morphogenesis	PAX6 MEIS1 NOTCH2 FOXF2 LARGE1	1.33e-04	204	50	5	GO:0048592
GeneOntologyBiologicalProcess	eye development	SRF PAX6 MEIS1 MEIS2 NOTCH2 FOXF2 LARGE1	1.49e-04	480	50	7	GO:0001654
GeneOntologyBiologicalProcess	visual system development	SRF PAX6 MEIS1 MEIS2 NOTCH2 FOXF2 LARGE1	1.55e-04	483	50	7	GO:0150063
GeneOntologyBiologicalProcess	axis specification	CDX4 SRF PAX6 NOTCH2	1.62e-04	113	50	4	GO:0009798
GeneOntologyBiologicalProcess	sensory system development	SRF PAX6 MEIS1 MEIS2 NOTCH2 FOXF2 LARGE1	1.71e-04	491	50	7	GO:0048880
GeneOntologyBiologicalProcess	neuron migration	PTPRZ1 SRF PAX6 PCM1 LARGE1	1.81e-04	218	50	5	GO:0001764
GeneOntologyBiologicalProcess	miRNA metabolic process	RC3H2 SRF PAX6 NOTCH2	1.98e-04	119	50	4	GO:0010586
GeneOntologyBiologicalProcess	copper ion transmembrane transport	SLC11A2 SLC31A1	2.05e-04	9	50	2	GO:0035434
GeneOntologyBiologicalProcess	cardiac muscle cell development	SGCD SRF MEIS1 LARGE1	2.17e-04	122	50	4	GO:0055013
GeneOntologyBiologicalProcess	neural precursor cell proliferation	FOXO1 PTPRZ1 PAX6 PCM1 NOTCH2	2.47e-04	233	50	5	GO:0061351
GeneOntologyBiologicalProcess	interkinetic nuclear migration	PAX6 PCM1	2.56e-04	10	50	2	GO:0022027
GeneOntologyBiologicalProcess	pattern specification process	ALX3 CDX4 SRF PAX6 MEIS1 MEIS2 NOTCH2	2.60e-04	526	50	7	GO:0007389
GeneOntologyBiologicalProcess	cardiac cell development	SGCD SRF MEIS1 LARGE1	2.94e-04	132	50	4	GO:0055006
GeneOntologyBiologicalProcess	regulation of hemopoiesis	RASGRP1 RC3H2 KAT6A SMARCA2 MEIS1 MEIS2 NOTCH2	3.05e-04	540	50	7	GO:1903706
GeneOntologyBiologicalProcess	regulation of neural precursor cell proliferation	FOXO1 PTPRZ1 PAX6 NOTCH2	3.20e-04	135	50	4	GO:2000177
GeneOntologyBiologicalProcess	head development	TFAP2D KAT6A SRF PAX6 CIC MEIS1 MEIS2 PCM1 LARGE1	3.21e-04	919	50	9	GO:0060322
GeneOntologyBiologicalProcess	erythrocyte development	SLC11A2 SRF ALAS1	3.22e-04	55	50	3	GO:0048821
GeneOntologyBiologicalProcess	embryonic organ development	ALX3 CDX4 KAT6A SRF PAX6 NOTCH2 FOXF2	3.84e-04	561	50	7	GO:0048568
GeneOntologyBiologicalProcess	positive regulation of miRNA transcription	SRF PAX6 NOTCH2	4.37e-04	61	50	3	GO:1902895
GeneOntologyBiologicalProcess	pancreatic A cell differentiation	PAX6 ONECUT1	5.14e-04	14	50	2	GO:0003310
GeneOntologyBiologicalProcess	camera-type eye development	SRF PAX6 MEIS1 NOTCH2 FOXF2 LARGE1	5.52e-04	426	50	6	GO:0043010
GeneOntologyBiologicalProcess	negative regulation of developmental process	FOXO1 RC3H2 PTPRZ1 SMARCA2 ANKRD26 PAX6 HUWE1 MEIS1 MEIS2 PCM1	5.92e-04	1220	50	10	GO:0051093
GeneOntologyBiologicalProcess	growth	PAPPA2 RC3H2 TLE5 SRF SMARCA2 ANKRD26 MEIS1 NOTCH2 DNM2 LARGE1	6.52e-04	1235	50	10	GO:0040007
GeneOntologyBiologicalProcess	positive regulation of miRNA metabolic process	SRF PAX6 NOTCH2	7.40e-04	73	50	3	GO:2000630
GeneOntologyBiologicalProcess	mononuclear cell differentiation	RASGRP1 RC3H2 SRF SMARCA2 ONECUT1 NOTCH2 LARGE1	8.40e-04	640	50	7	GO:1903131
GeneOntologyBiologicalProcess	negative regulation of transcription by RNA polymerase II	RALGAPA1 FOXO1 CDX4 TLE5 SMARCA2 PAX6 CIC MEIS2 NOTCH2	8.60e-04	1053	50	9	GO:0000122
GeneOntologyBiologicalProcess	cardiac muscle cell differentiation	SGCD SRF MEIS1 LARGE1	8.87e-04	177	50	4	GO:0055007
GeneOntologyBiologicalProcess	aorta development	KAT6A SRF DNM2	9.66e-04	80	50	3	GO:0035904
GeneOntologyBiologicalProcess	brain development	TFAP2D SRF PAX6 CIC MEIS1 MEIS2 PCM1 LARGE1	9.95e-04	859	50	8	GO:0007420
GeneOntologyBiologicalProcess	regulation of transcription initiation by RNA polymerase II	FOXO1 SRF MED13	1.00e-03	81	50	3	GO:0060260
GeneOntologyBiologicalProcess	copper ion transport	SLC11A2 SLC31A1	1.06e-03	20	50	2	GO:0006825
GeneOntologyBiologicalProcess	coronary vasculature development	SGCD SRF DNM2	1.07e-03	83	50	3	GO:0060976
GeneOntologyBiologicalProcess	regulation of miRNA transcription	SRF PAX6 NOTCH2	1.07e-03	83	50	3	GO:1902893
GeneOntologyBiologicalProcess	miRNA transcription	SRF PAX6 NOTCH2	1.11e-03	84	50	3	GO:0061614
GeneOntologyBiologicalProcess	negative regulation of cell differentiation	FOXO1 RC3H2 SMARCA2 ANKRD26 PAX6 MEIS1 MEIS2 PCM1	1.12e-03	875	50	8	GO:0045596
GeneOntologyBiologicalProcess	cardiac muscle tissue development	SGCD SRF MEIS1 NOTCH2 LARGE1	1.15e-03	327	50	5	GO:0048738
GeneOntologyBiologicalProcess	regulation of DNA-templated transcription initiation	FOXO1 SRF MED13	1.40e-03	91	50	3	GO:2000142
GeneOntologyBiologicalProcess	glandular epithelial cell differentiation	NR5A2 PAX6 ONECUT1	1.40e-03	91	50	3	GO:0002067
GeneOntologyBiologicalProcess	sensory organ morphogenesis	PAX6 MEIS1 NOTCH2 FOXF2 LARGE1	1.42e-03	343	50	5	GO:0090596
GeneOntologyBiologicalProcess	regulation of neurogenesis	PTPRZ1 SRF HLTF PAX6 PCM1 NOTCH2	1.47e-03	515	50	6	GO:0050767
GeneOntologyBiologicalProcess	striated muscle tissue development	SGCD SRF MEIS1 NOTCH2 LARGE1	1.53e-03	349	50	5	GO:0014706
GeneOntologyBiologicalProcess	embryonic organ morphogenesis	ALX3 SRF PAX6 NOTCH2 FOXF2	1.57e-03	351	50	5	GO:0048562
GeneOntologyBiologicalProcess	positive regulation of neuron migration	PTPRZ1 PAX6	1.67e-03	25	50	2	GO:2001224
GeneOntologyBiologicalProcess	positive regulation of Ras protein signal transduction	RASGRP1 NOTCH2	1.67e-03	25	50	2	GO:0046579
GeneOntologyBiologicalProcess	tube development	RC3H2 SLC31A1 SGCD KAT6A SRF PAX6 CIC MEIS1 NOTCH2 FOXF2	1.71e-03	1402	50	10	GO:0035295
GeneOntologyBiologicalProcess	muscle cell differentiation	SGCD SRF SMARCA2 MEIS1 NOTCH2 LARGE1	1.72e-03	531	50	6	GO:0042692
GeneOntologyBiologicalProcess	smooth muscle cell differentiation	SRF SMARCA2 NOTCH2	1.79e-03	99	50	3	GO:0051145
GeneOntologyBiologicalProcess	sensory organ development	SRF PAX6 MEIS1 MEIS2 NOTCH2 FOXF2 LARGE1	1.79e-03	730	50	7	GO:0007423
GeneOntologyBiologicalProcess	neuronal stem cell population maintenance	FOXO1 PCM1	1.80e-03	26	50	2	GO:0097150
GeneOntologyBiologicalProcess	megakaryocyte development	SRF MEIS1	1.80e-03	26	50	2	GO:0035855
GeneOntologyBiologicalProcess	lymphocyte differentiation	RASGRP1 RC3H2 SRF SMARCA2 ONECUT1 NOTCH2	1.82e-03	537	50	6	GO:0030098
GeneOntologyCellularComponent	chromatin	ALX3 FOXO1 CDX4 TFAP2D KAT6A NR5A2 SRF SMARCA2 PAX6 SMCR8 ONECUT1 CIC MEIS1 MEIS2 FOXF2	1.11e-06	1480	50	15	GO:0000785
Domain	Notch_dom	PAPPA2 PAPPA NOTCH2	5.90e-07	7	49	3	IPR000800
Domain	Notch	PAPPA2 PAPPA NOTCH2	5.90e-07	7	49	3	PF00066
Domain	NL	PAPPA2 PAPPA NOTCH2	5.90e-07	7	49	3	SM00004
Domain	Peptidase_M43	PAPPA2 PAPPA	6.74e-06	2	49	2	IPR008754
Domain	Peptidase_M43	PAPPA2 PAPPA	6.74e-06	2	49	2	PF05572
Domain	Myxo_disulph_rpt	PAPPA2 PAPPA	2.02e-05	3	49	2	IPR011936
Domain	Homeobox	ALX3 CDX4 PAX6 ONECUT1 MEIS1 MEIS2	3.23e-05	234	49	6	PF00046
Domain	HOMEOBOX_1	ALX3 CDX4 PAX6 ONECUT1 MEIS1 MEIS2	3.39e-05	236	49	6	PS00027
Domain	HOX	ALX3 CDX4 PAX6 ONECUT1 MEIS1 MEIS2	3.47e-05	237	49	6	SM00389
Domain	HOMEOBOX_2	ALX3 CDX4 PAX6 ONECUT1 MEIS1 MEIS2	3.64e-05	239	49	6	PS50071
Domain	Homeobox_dom	ALX3 CDX4 PAX6 ONECUT1 MEIS1 MEIS2	3.64e-05	239	49	6	IPR001356
Domain	LamGL	PAPPA2 PAPPA	4.03e-05	4	49	2	SM00560
Domain	LamG-like	PAPPA2 PAPPA	4.03e-05	4	49	2	IPR006558
Domain	PKNOX/Meis_N	MEIS1 MEIS2	6.71e-05	5	49	2	IPR032453
Domain	Meis_PKNOX_N	MEIS1 MEIS2	6.71e-05	5	49	2	PF16493
Domain	-	ALX3 CDX4 PAX6 ONECUT1 MEIS1 MEIS2	9.29e-05	283	49	6	1.10.10.60
Domain	Homeodomain-like	ALX3 CDX4 PAX6 ONECUT1 MEIS1 MEIS2	2.21e-04	332	49	6	IPR009057
Domain	-	FOXO1 KAT6A RGS9 PAX6 FOXF2	2.60e-04	218	49	5	1.10.10.10
Domain	WHTH_DNA-bd_dom	FOXO1 KAT6A RGS9 PAX6 FOXF2	4.20e-04	242	49	5	IPR011991
Domain	Homeobox_KN	MEIS1 MEIS2	8.94e-04	17	49	2	PF05920
Domain	Homeobox_KN_domain	MEIS1 MEIS2	8.94e-04	17	49	2	IPR008422
Domain	MetalloPept_cat_dom	PAPPA2 PAPPA MMP15	1.25e-03	81	49	3	IPR024079
Domain	-	PAPPA2 PAPPA MMP15	1.25e-03	81	49	3	3.40.390.10
Domain	ZINC_PROTEASE	PAPPA2 PAPPA MMP15	2.17e-03	98	49	3	PS00142
Domain	SNF2_N	SMARCA2 HLTF	3.18e-03	32	49	2	IPR000330
Domain	SNF2_N	SMARCA2 HLTF	3.18e-03	32	49	2	PF00176
Domain	-	NAT8L KAT6A	4.94e-03	40	49	2	3.40.630.30
Domain	Acyl_CoA_acyltransferase	NAT8L KAT6A	6.21e-03	45	49	2	IPR016181
Domain	TF_fork_head_CS_2	FOXO1 FOXF2	6.48e-03	46	49	2	IPR030456
Domain	TF_fork_head_CS_1	FOXO1 FOXF2	6.76e-03	47	49	2	IPR018122
Domain	FH	FOXO1 FOXF2	7.33e-03	49	49	2	SM00339
Domain	FORK_HEAD_1	FOXO1 FOXF2	7.33e-03	49	49	2	PS00657
Domain	FORK_HEAD_2	FOXO1 FOXF2	7.33e-03	49	49	2	PS00658
Domain	Fork_head_dom	FOXO1 FOXF2	7.33e-03	49	49	2	IPR001766
Domain	FORK_HEAD_3	FOXO1 FOXF2	7.33e-03	49	49	2	PS50039
Domain	Forkhead	FOXO1 FOXF2	7.33e-03	49	49	2	PF00250
Pathway	REACTOME_REGULATION_OF_BETA_CELL_DEVELOPMENT	FOXO1 NR5A2 PAX6 ONECUT1	6.36e-06	42	41	4	M17541
Pathway	KEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG	NR5A2 PAX6 ONECUT1	5.02e-05	25	41	3	M18312
Pathway	REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_EARLY_PANCREATIC_PRECURSOR_CELLS	NR5A2 ONECUT1	2.29e-04	8	41	2	M27123
Pubmed	Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.	ALX3 FOXO1 CDX4 NR5A2 PAX6 ONECUT1 CIC MEIS1 MEIS2 FOXF2	9.20e-12	263	54	10	20932939
Pubmed	A census of human transcription factors: function, expression and evolution.	ALX3 FOXO1 RC3H2 CDX4 TFAP2D NR5A2 SRF PLAGL2 PAX6 ONECUT1 CIC MEIS1 MEIS2 FOXF2	7.62e-11	908	54	14	19274049
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	FOXO1 CDX4 GTF3C1 NR5A2 SRF SMARCA2 PLAGL2 PAX6 ONECUT1 CIC MEIS1 MEIS2	7.37e-10	709	54	12	22988430
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	FOXO1 CDX4 NR5A2 SRF SMARCA2 HLTF PLAGL2 PAX6 ONECUT1 CIC MEIS1 MEIS2	3.20e-09	808	54	12	20412781
Pubmed	Evidence for an evolutionary conserved role of homothorax/Meis1/2 during vertebrate retina development.	PAX6 MEIS1 MEIS2	3.54e-09	3	54	3	18216174
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	ALX3 CDX4 TFAP2D GTF3C1 NR5A2 HLTF PLAGL2 PAX6 CIC MEIS1 MEIS2	8.77e-08	877	54	11	20211142
Pubmed	Precise temporal control of the eye regulatory gene Pax6 via enhancer-binding site affinity.	PAX6 MEIS1 MEIS2	1.23e-07	7	54	3	20413611
Pubmed	Meis homeoproteins directly regulate Pax6 during vertebrate lens morphogenesis.	PAX6 MEIS1 MEIS2	2.95e-07	9	54	3	12183364
Pubmed	Transcription factors expressed in olfactory bulb local progenitor cells revealed by genome-wide transcriptome profiling.	FOXO1 SMARCA2 PLAGL2 PAX6 MEIS2	3.14e-07	91	54	5	21194568
Pubmed	Lens morphogenesis is dependent on Pax6-mediated inhibition of the canonical Wnt/beta-catenin signaling in the lens surface ectoderm.	PAX6 MEIS1 MEIS2	5.79e-07	11	54	3	20027618
Pubmed	Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype.	PAX6 MEIS1 MEIS2	1.00e-06	13	54	3	16847320
Pubmed	Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development.	PAX6 MEIS1 MEIS2	1.00e-06	13	54	3	17049510
Pubmed	The Gene Regulatory Network of Lens Induction Is Wired through Meis-Dependent Shadow Enhancers of Pax6.	PAX6 MEIS1 MEIS2	1.00e-06	13	54	3	27918583
Pubmed	Dynamic expression of MEIS1 homeoprotein in E14.5 forebrain and differentiated forebrain-derived neural stem cells.	PAX6 MEIS1 MEIS2	1.59e-06	15	54	3	23756022
Pubmed	Glucose-dependent downregulation of glucagon gene expression mediated by selective interactions between ALX3 and PAX6 in mouse alpha cells.	ALX3 PAX6	2.37e-06	2	54	2	26739814
Pubmed	Myeloid ecotropic viral integration site 1 (MEIS) 1 involvement in embryonic implantation.	MEIS1 MEIS2	2.37e-06	2	54	2	18408019
Pubmed	Spatiotemporal distribution of PAX6 and MEIS2 expression and total cell numbers in the ganglionic eminence in the early developing human forebrain.	PAX6 MEIS2	2.37e-06	2	54	2	20523026
Pubmed	CRISP-R/Cas9 Mediated Deletion of Copper Transport Genes CTR1 and DMT1 in NSCLC Cell Line H1299. Biological and Pharmacological Consequences.	SLC11A2 SLC31A1	2.37e-06	2	54	2	30959888
Pubmed	Control of mouse limb initiation and antero-posterior patterning by Meis transcription factors.	MEIS1 MEIS2	2.37e-06	2	54	2	34035267
Pubmed	Copper uptake by DMT1: a compensatory mechanism for CTR1 deficiency in human umbilical vein endothelial cells.	SLC11A2 SLC31A1	2.37e-06	2	54	2	26067577
Pubmed	Pregnancy-associated plasma protein-A2 (PAPP-A2): tissue expression and biological consequences of gene knockout in mice.	PAPPA2 PAPPA	2.37e-06	2	54	2	21586553
Pubmed	Pregnancy associated plasma protein-A as a prognostic biomarker of all-cause mortality and cardiovascular events in patients presenting with chest pain: a systematic review.	PAPPA2 PAPPA	2.37e-06	2	54	2	29144175
Pubmed	Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model.	CDX4 MEIS1	2.37e-06	2	54	2	17068127
Pubmed	Iron, copper, and zinc transport: inhibition of divalent metal transporter 1 (DMT1) and human copper transporter 1 (hCTR1) by shRNA.	SLC11A2 SLC31A1	2.37e-06	2	54	2	22068728
Pubmed	Homeodomain proteins: an update.	ONECUT1 MEIS2	2.37e-06	2	54	2	26464018
Pubmed	MEIS1 and MEIS2 Expression and Prostate Cancer Progression: A Role For HOXB13 Binding Partners in Metastatic Disease.	MEIS1 MEIS2	2.37e-06	2	54	2	29716922
Pubmed	ALAS1 gene expression is down-regulated by Akt-mediated phosphorylation and nuclear exclusion of FOXO1 by vanadate in diabetic mice.	FOXO1 ALAS1	2.37e-06	2	54	2	22070747
Pubmed	Mutational analysis of the proteolytic domain of pregnancy-associated plasma protein-A (PAPP-A): classification as a metzincin.	PAPPA2 PAPPA	2.37e-06	2	54	2	11513734
Pubmed	Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3.	PAX6 ONECUT1 NOTCH2	2.84e-06	18	54	3	10825208
Pubmed	Meis1 coordinates a network of genes implicated in eye development and microphthalmia.	PAX6 MEIS1 MEIS2	2.84e-06	18	54	3	26253404
Pubmed	Deterministic and stochastic allele specific gene expression in single mouse blastomeres.	SLC31A1 KAT6A NR5A2 PAX6 ONECUT1 MEIS1 NOTCH2	4.12e-06	424	54	7	21731673
Pubmed	Stromal netrin 1 coordinates renal arteriogenesis and mural cell differentiation.	PAX6 MEIS1 MEIS2	5.34e-06	22	54	3	37823339
Pubmed	Neural crest cells require Meis2 for patterning the mandibular arch via the Sonic hedgehog pathway.	MEIS1 MEIS2 FOXF2	6.13e-06	23	54	3	32616504
Pubmed	DNA-dependent formation of transcription factor pairs alters their binding specificity.	MEIS1 MEIS2	7.09e-06	3	54	2	26550823
Pubmed	Placental expression of PAPPA, PAPPA-2 and PLAC-1 in pregnacies is associated with FGR.	PAPPA2 PAPPA	7.09e-06	3	54	2	29532882
Pubmed	Conserved regulation of proximodistal limb axis development by Meis1/Hth.	MEIS1 MEIS2	7.09e-06	3	54	2	10586884
Pubmed	Altered placental expression of PAPPA2 does not affect birth weight in mice.	PAPPA2 PAPPA	7.09e-06	3	54	2	20642865
Pubmed	Meis2 is a Pax6 co-factor in neurogenesis and dopaminergic periglomerular fate specification in the adult olfactory bulb.	PAX6 MEIS2	7.09e-06	3	54	2	24284204
Pubmed	SRF-FOXO1 and SRF-NCOA1 Fusion Genes Delineate a Distinctive Subset of Well-differentiated Rhabdomyosarcoma.	FOXO1 SRF	7.09e-06	3	54	2	32187044
Pubmed	Increased levels of pregnancy-associated plasma protein-A2 in the serum of pre-eclamptic patients.	PAPPA2 PAPPA	7.09e-06	3	54	2	18805800
Pubmed	Meis homeobox genes control progenitor competence in the retina.	PAX6 MEIS1 MEIS2	7.94e-06	25	54	3	33723039
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	SERPINA3 SGCD MED12L ANKRD26 MED13 NOTCH2 DNM2	1.16e-05	497	54	7	23414517
Pubmed	The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo.	TLE5 PAX6 ONECUT1 MEIS1 MEIS2	1.21e-05	191	54	5	24146773
Pubmed	Insights into the etiology and physiopathology of MODY5/HNF1B pancreatic phenotype with a mouse model of the human disease.	NR5A2 PAX6 ONECUT1	1.26e-05	29	54	3	33527355
Pubmed	Molecular mechanism of synovial joint site specification and induction in developing vertebrate limbs.	MEIS1 MEIS2	1.42e-05	4	54	2	37272420
Pubmed	Expression patterns of homeobox genes in the mouse vomeronasal organ at postnatal stages.	MEIS1 MEIS2	1.42e-05	4	54	2	27521061
Pubmed	Identification of a conserved family of Meis1-related homeobox genes.	MEIS1 MEIS2	1.42e-05	4	54	2	9049632
Pubmed	The nuclear oncoprotein TLX1/HOX11 associates with pericentromeric satellite 2 DNA in leukemic T-cells.	MEIS1 MEIS2	1.42e-05	4	54	2	16357834
Pubmed	Polo-Like Kinase 3 Appears Dispensable for Normal Retinal Development Despite Robust Embryonic Expression.	TFAP2D PAX6 ONECUT1	2.05e-05	34	54	3	26949938
Pubmed	Impact of cytosine methylation on DNA binding specificities of human transcription factors.	ALX3 CDX4 NR5A2 SRF PAX6 ONECUT1 MEIS2	2.07e-05	544	54	7	28473536
Pubmed	A cellular and molecular mosaic establishes growth and differentiation states for cranial sensory neurons.	PAX6 ONECUT1 MEIS1	2.24e-05	35	54	3	26988119
Pubmed	MGE-derived nNOS+ interneurons promote fear acquisition in nNOS-/- mice.	PAX6 MEIS2	2.36e-05	5	54	2	28974418
Pubmed	Arginine methylation by PRMT5 at a naturally occurring mutation site is critical for liver metabolic regulation by small heterodimer partner.	NR5A2 SMARCA2	2.36e-05	5	54	2	21262773
Pubmed	FoxO1-dependent induction of acute myeloid leukemia by osteoblasts in mice.	FOXO1 NOTCH2	2.36e-05	5	54	2	26108693
Pubmed	Expression of Meis and Pbx genes and their protein products in the developing telencephalon: implications for regional differentiation.	MEIS1 MEIS2	2.36e-05	5	54	2	10842069
Pubmed	The SWI/SNF chromatin remodeling complex regulates myocardin-induced smooth muscle-specific gene expression.	SRF SMARCA2	2.36e-05	5	54	2	19342595
Pubmed	Hoxa2 selectively enhances Meis binding to change a branchial arch ground state.	MEIS1 MEIS2	2.36e-05	5	54	2	25640223
Pubmed	HOX cofactors expression and regulation in the human ovary.	MEIS1 MEIS2	2.36e-05	5	54	2	18973687
Pubmed	Dental Epithelial Stem Cells Express the Developmental Regulator Meis1.	MEIS1 MEIS2	2.36e-05	5	54	2	30914971
Pubmed	RPTPζ/phosphacan is abnormally glycosylated in a model of muscle-eye-brain disease lacking functional POMGnT1.	PTPRZ1 LARGE1	2.36e-05	5	54	2	22728091
Pubmed	Defects in tangential neuronal migration of pontine nuclei neurons in the Largemyd mouse are associated with stalled migration in the ventrolateral hindbrain.	PAX6 LARGE1	2.36e-05	5	54	2	16819976
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	GTF3C1 SMARCA2 HUWE1 CIC MED13 PCM1 NOTCH2 DNM2	2.44e-05	774	54	8	15302935
Pubmed	Transcription Factors YAP/TAZ and SRF Cooperate To Specify Renal Myofibroblasts in the Developing Mouse Kidney.	SRF MEIS1 MEIS2	2.65e-05	37	54	3	35918150
Pubmed	A conserved non-homeodomain Hoxa9 isoform interacting with CBP is co-expressed with the 'typical' Hoxa9 protein during embryogenesis.	MEIS1 MEIS2	3.54e-05	6	54	2	15161102
Pubmed	Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors.	TLE5 PAX6	3.54e-05	6	54	2	12050133
Pubmed	Ligand-dependent regulation of the activity of the orphan nuclear receptor, small heterodimer partner (SHP), in the repression of bile acid biosynthetic CYP7A1 and CYP8B1 genes.	NR5A2 SMARCA2	3.54e-05	6	54	2	21566081
Pubmed	MEIS proteins as partners of the TLX1/HOX11 oncoprotein.	MEIS1 MEIS2	3.54e-05	6	54	2	19559479
Pubmed	Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes.	MEIS1 MEIS2	3.54e-05	6	54	2	11438208
Pubmed	Hox/Pbx and Brn binding sites mediate Pax3 expression in vitro and in vivo.	MEIS1 MEIS2	3.54e-05	6	54	2	15465489
Pubmed	Sarcoglycan complex: implications for metabolic defects in muscular dystrophies.	SGCD LARGE1	4.94e-05	7	54	2	19494113
Pubmed	Six3 activation of Pax6 expression is essential for mammalian lens induction and specification.	PAX6 MEIS1	4.94e-05	7	54	2	17066077
Pubmed	Forkhead box F1 is essential for migration of mesenchymal cells and directly induces integrin-beta3 expression.	ONECUT1 FOXF2	4.94e-05	7	54	2	17261592
Pubmed	Regulation of EphA8 gene expression by TALE homeobox transcription factors during development of the mesencephalon.	MEIS1 MEIS2	4.94e-05	7	54	2	17178831
Pubmed	PBX, MEIS, and IGF-I are potential mediators of retinoic acid-induced proximodistal limb reduction defects.	MEIS1 MEIS2	4.94e-05	7	54	2	12397630
Pubmed	Nuclear receptor NR5A2 controls neural stem cell fate decisions during development.	NR5A2 PAX6	4.94e-05	7	54	2	27447294
Pubmed	Cdx2 and the Brm-type SWI/SNF complex cooperatively regulate villin expression in gastrointestinal cells.	CDX4 SMARCA2	4.94e-05	7	54	2	19371634
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	FOXO1 NOP14 GTF3C1 HUWE1 CIC MEIS1 NOTCH2 FOXF2	5.02e-05	857	54	8	25609649
Pubmed	Molecular architecture of the developing mouse brain.	ALX3 PTPRZ1 PAPPA PAX6	5.41e-05	132	54	4	34321664
Pubmed	Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways.	FOXO1 PAX6 MEIS1 MEIS2	5.74e-05	134	54	4	19030180
Pubmed	Human CCAAT/enhancer-binding protein β interacts with chromatin remodeling complexes of the imitation switch subfamily.	SMARCA2 HLTF MEIS1	5.82e-05	48	54	3	22242598
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	NOP14 GTF3C1 XRN1 SMARCA2 HUWE1 PCM1 DNM2	6.56e-05	653	54	7	22586326
Pubmed	Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment.	NR5A2 ONECUT1 NOTCH2	6.59e-05	50	54	3	24449835
Pubmed	Antagonism between retinoic acid and fibroblast growth factor signaling during limb development.	MEIS1 MEIS2	6.59e-05	8	54	2	23623500
Pubmed	Discovery of genes required for body axis and limb formation by global identification of retinoic acid-regulated epigenetic marks.	MEIS1 MEIS2	6.59e-05	8	54	2	32421711
Pubmed	Defining the membrane proteome of NK cells.	NOP14 SLC11A2 GTF3C1 XRN1 HLTF HUWE1 MED13 PCM1 NOTCH2	7.19e-05	1168	54	9	19946888
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	RALGAPA1 NAT8L GTF3C1 PCLO XRN1 PCM1	8.01e-05	462	54	6	31138677
Pubmed	Tenascin C regulates proliferation and differentiation processes during embryonic retinogenesis and modulates the de-differentiation capacity of Müller glia by influencing growth factor responsiveness and the extracellular matrix compartment.	PTPRZ1 PAX6	8.46e-05	9	54	2	22691363
Pubmed	Proximo-distal positional information encoded by an Fgf-regulated gradient of homeodomain transcription factors in the vertebrate limb.	MEIS1 MEIS2	8.46e-05	9	54	2	32537491
Pubmed	Molecular markers of neuronal progenitors in the embryonic cerebellar anlage.	MEIS1 MEIS2	8.46e-05	9	54	2	17122047
Pubmed	Macrophages restrict the nephrogenic field and promote endothelial connections during kidney development.	MEIS1 MEIS2	8.46e-05	9	54	2	30758286
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	RALGAPA1 GTF3C1 SLC31A1 TLE5 KAT6A SRF SMARCA2 HUWE1 PCM1 NOTCH2	8.59e-05	1489	54	10	28611215
Pubmed	Variant PRC1 competes with retinoic acid-related signals to repress Meis2 in the mouse distal forelimb bud.	MEIS1 MEIS2	1.06e-04	10	54	2	30190278
Pubmed	Members of the Plag gene family are expressed in complementary and overlapping regions in the developing murine nervous system.	PLAGL2 PAX6	1.06e-04	10	54	2	16193498
Pubmed	A unique stylopod patterning mechanism by Shox2-controlled osteogenesis.	MEIS1 MEIS2	1.06e-04	10	54	2	27287812
Pubmed	Identification of a new family of Pbx-related homeobox genes.	MEIS1 MEIS2	1.06e-04	10	54	2	8950991
Pubmed	Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas.	PAX6 ONECUT1	1.06e-04	10	54	2	14570708
Pubmed	Conserved expression of ultra-conserved noncoding RNA in mammalian nervous system.	RC3H2 PAX6 MEIS2	1.14e-04	60	54	3	29055695
Pubmed	Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors.	MEIS1 MEIS2	1.29e-04	11	54	2	18787068
Pubmed	Plasticity and expanding complexity of the hepatic transcription factor network during liver development.	NR5A2 ONECUT1	1.29e-04	11	54	2	16912278
Pubmed	RNA profiling and chromatin immunoprecipitation-sequencing reveal that PTF1a stabilizes pancreas progenitor identity via the control of MNX1/HLXB9 and a network of other transcription factors.	NR5A2 ONECUT1	1.55e-04	12	54	2	22232429
Interaction	PITX1 interactions	FOXO1 CDX4 TFAP2D TLE5 SMARCA2 CIC	7.04e-07	127	50	6	int:PITX1
Interaction	CREBBP interactions	FOXO1 TFAP2D KAT6A SRF SMARCA2 PAPPA PAX6 HUWE1 ONECUT1 MEIS1	1.76e-06	599	50	10	int:CREBBP
Interaction	PBX1 interactions	PAX6 HUWE1 CIC MEIS1 MEIS2	2.16e-06	85	50	5	int:PBX1
Interaction	SP2 interactions	RC3H2 KAT6A SRF NOTCH2	2.59e-06	39	50	4	int:SP2
Interaction	HOXA5 interactions	FOXO1 CDX4 KAT6A CIC MEIS1	3.56e-06	94	50	5	int:HOXA5
Interaction	TLX1 interactions	TLE5 KAT6A SMARCA2 CIC MEIS1 MEIS2	4.55e-06	175	50	6	int:TLX1
Interaction	HOXA11 interactions	FOXO1 CIC MEIS1	1.85e-05	21	50	3	int:HOXA11
Interaction	NFIX interactions	GTF3C1 TLE5 SRF SMARCA2 PAX6 CIC	2.01e-05	227	50	6	int:NFIX
Interaction	HGH1 interactions	NOP14 GTF3C1 TLE5 KAT6A	2.03e-05	65	50	4	int:HGH1
Interaction	HOXA13 interactions	CIC MEIS1 MEIS2	2.14e-05	22	50	3	int:HOXA13
Interaction	RB1CC1 interactions	FOXO1 KAT6A ANKRD26 HUWE1 SMCR8 CIC PCM1	4.47e-05	387	50	7	int:RB1CC1
Interaction	NR0B2 interactions	FOXO1 NR5A2 SMARCA2 ONECUT1	5.33e-05	83	50	4	int:NR0B2
Interaction	MAZ interactions	RC3H2 KAT6A CIC NOTCH2	6.13e-05	86	50	4	int:MAZ
Interaction	ZBTB39 interactions	KAT6A CIC NOTCH2	7.44e-05	33	50	3	int:ZBTB39
Interaction	LMX1B interactions	CIC MEIS1 MEIS2	8.89e-05	35	50	3	int:LMX1B
Interaction	MED4 interactions	TLE5 XRN1 MED12L ANKRD26 HUWE1 MED13 PCM1	1.15e-04	450	50	7	int:MED4
Interaction	TRPV3 interactions	NAT8L MMP15	1.26e-04	7	50	2	int:TRPV3
Interaction	TBX2 interactions	TFAP2D CIC MEIS2	1.33e-04	40	50	3	int:TBX2
Interaction	HOXB1 interactions	SERPINA3 PAX6 MEIS1	1.43e-04	41	50	3	int:HOXB1
Interaction	EN1 interactions	TLE5 PAX6 CIC MEIS1	1.59e-04	110	50	4	int:EN1
Interaction	MAGEA9 interactions	RC3H2 ALAS1 SMCR8 MEIS1 MEIS2	1.62e-04	208	50	5	int:MAGEA9
Interaction	POLR1G interactions	FOXO1 RC3H2 NOP14 GTF3C1 KAT6A HUWE1 CIC	1.92e-04	489	50	7	int:POLR1G
Interaction	SIX4 interactions	SRF PAX6 CIC	2.02e-04	46	50	3	int:SIX4
Interaction	IRX2 interactions	TLE5 PLAGL2	2.15e-04	9	50	2	int:IRX2
Interaction	ZKSCAN2 interactions	SMARCA2 NOTCH2	2.15e-04	9	50	2	int:ZKSCAN2
Interaction	MED12L interactions	TLE5 MED12L MED13	2.16e-04	47	50	3	int:MED12L
Interaction	ZFP64 interactions	KAT6A CIC NOTCH2	2.44e-04	49	50	3	int:ZFP64
Interaction	ZNF629 interactions	RC3H2 KAT6A CIC NOTCH2	2.45e-04	123	50	4	int:ZNF629
Interaction	FOXC1 interactions	RC3H2 SMARCA2 PAX6 CIC MEIS1	2.48e-04	228	50	5	int:FOXC1
Interaction	PAX6 interactions	GTF3C1 TLE5 SMARCA2 PAX6 CIC MEIS2	2.79e-04	366	50	6	int:PAX6
Interaction	PAX9 interactions	TLE5 SMARCA2 PLAGL2 CIC	3.03e-04	130	50	4	int:PAX9
Interaction	RPS23 interactions	FOXO1 RC3H2 GTF3C1 HUWE1 CIC NOTCH2	3.09e-04	373	50	6	int:RPS23
Interaction	ZBTB7A interactions	GTF3C1 HUWE1 CIC DNM2	3.12e-04	131	50	4	int:ZBTB7A
Interaction	HOXC9 interactions	TLE5 PAX6 CIC	3.26e-04	54	50	3	int:HOXC9
Interaction	SINHCAF interactions	SERPINA3 PAX6 HUWE1 CIC	3.49e-04	135	50	4	int:SINHCAF
Cytoband	Ensembl 112 genes in cytogenetic band chr9q33	RC3H2 PAPPA ADGRD2	5.89e-04	138	54	3	chr9q33
Cytoband	15q14	RASGRP1 MEIS2	1.54e-03	49	54	2	15q14
Cytoband	Ensembl 112 genes in cytogenetic band chr15q14	RASGRP1 MEIS2	2.38e-03	61	54	2	chr15q14
Cytoband	4p16.3	NAT8L NOP14	4.55e-03	85	54	2	4p16.3
GeneFamily	Pappalysins\|Sushi domain containing	PAPPA2 PAPPA	4.30e-06	2	38	2	897
GeneFamily	TALE class homeoboxes and pseudogenes	MEIS1 MEIS2	1.35e-03	26	38	2	526
GeneFamily	Cyclins\|Mediator complex	MED12L MED13	2.18e-03	33	38	2	1061
GeneFamily	Forkhead boxes	FOXO1 FOXF2	3.68e-03	43	38	2	508
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	PAPPA2 PAPPA	6.38e-03	57	38	2	1179
CoexpressionAtlas	DevelopingKidney_e15.5_anlage of loop of Henle_emap-31283_top-relative-expression-ranked_1000	PAPPA2 RALGAPA1 RC3H2 SULT1C2 MED12L HLTF HUWE1 MED13 MEIS1 DNM2	1.35e-05	795	50	10	gudmap_developingKidney_e15.5_anlage of loop of Henle_1000
CoexpressionAtlas	DevelopingKidney_e15.5_anlage of loop of Henle_emap-31283_top-relative-expression-ranked_500	PAPPA2 RALGAPA1 MED12L HLTF HUWE1 MED13 DNM2	4.10e-05	402	50	7	gudmap_developingKidney_e15.5_anlage of loop of Henle_500
ToppCell	-Unknown-Endothelial-Myofibroblast\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FOXO1 XRN1 RGS9 MEIS1 NOTCH2 LARGE1	1.07e-07	188	54	6	6468fa95ad0395395301115286f2d8c0df5d3882
ToppCell	-Unknown-Endothelial\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FOXO1 XRN1 RGS9 MEIS1 NOTCH2 LARGE1	1.07e-07	188	54	6	7a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell	-Unknown\| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FOXO1 XRN1 RGS9 MEIS1 NOTCH2 LARGE1	1.07e-07	188	54	6	9cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCLO XRN1 PAX6 HUWE1 PCM1	3.87e-06	195	54	5	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RASGRP1 SLC11A2 SGCD PAPPA	4.45e-05	162	54	4	285e6d553f485fd9f1075c4e1b940da251b5ea35
ToppCell	CV-Severe-7\|Severe / Virus stimulation, Condition and Cluster	SLC11A2 HUWE1 MEIS2 PCM1	6.28e-05	177	54	4	82fdd6185b368f54f03de389427cbe3071d21a99
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAT8L PCLO RGS9 MEIS2	6.42e-05	178	54	4	1bddbc083c36657bd6910f7466126ab325e88176
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NAT8L PCLO RGS9 MEIS2	6.42e-05	178	54	4	a74e5a390cbeaca9de1fdb7b2a0e50783bd202dd
ToppCell	3'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell-SMG_duct-SMG_duct_L.0.6.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SERPINA3 PAX6 MEIS1 MEIS2	6.56e-05	179	54	4	ec331b1132f965581f851a3b29e62873c4140e6c
ToppCell	390C-Fibroblasts-Fibroblast-G\|390C / Donor, Lineage, Cell class and subclass (all cells)	SERPINA3 SGCD PAPPA FOXF2	6.70e-05	180	54	4	137fc14859c89e1ecd98bee388bb58c04b835847
ToppCell	3'_v3-bone_marrow-Mast\|bone_marrow / Manually curated celltypes from each tissue	CDK15 MED12L ALAS1 MEIS2	6.70e-05	180	54	4	b37ee81b792213d6595b4ec65d04bc35d83321c7
ToppCell	390C-Fibroblasts-Fibroblast-G-\|390C / Donor, Lineage, Cell class and subclass (all cells)	SERPINA3 SGCD PAPPA FOXF2	6.70e-05	180	54	4	cd6790de050151fedfa2c5ea6ad58b72665414b2
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SGCD PAPPA MEIS1 MEIS2	7.00e-05	182	54	4	3dfa9187e9d2bab1d199079d29209c4648220ada
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC11A2 SMARCA2 PAPPA ALAS1	7.61e-05	186	54	4	aeac0c2db173cd1ea45b5052ab418d6cacd198d8
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Meis2-Meis2_Adamts19\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PAX6 MEIS1 MEIS2	7.75e-05	68	54	3	3a61ea2b234829632fabede72761aa6664550e56
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Meis2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PAX6 MEIS1 MEIS2	7.75e-05	68	54	3	3c5d0d35e4d1c5506a4a490e2f93e8024294207f
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC11A2 SGCD PAPPA ALAS1	8.10e-05	189	54	4	bfc76a72b600d641c8fe58346e5d8986c34f3981
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SGCD PAPPA MEIS1 NOTCH2	8.10e-05	189	54	4	45e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_T-CytoT_GZMH+-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	RASGRP1 GTF3C1 TLE5 RGS9	8.43e-05	191	54	4	b2d0ea24970da09209da9d9dda76e30fbfe22917
ToppCell	Control-Stromal_mesenchymal\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SGCD PAPPA MEIS1 NOTCH2	8.43e-05	191	54	4	14057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC11A2 SGCD SMARCA2 PAPPA	8.43e-05	191	54	4	96b78b4e819ea6052334bfcbc7abbf35897df885
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC11A2 SGCD PAPPA ALAS1	8.43e-05	191	54	4	7235a4d1601c88a2c8af571a2c04ab56d32f1b9a
ToppCell	ASK452-Immune-Mast_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	SLC11A2 CDK15 ALAS1 MEIS2	8.60e-05	192	54	4	8269b88ff6073a908f547fcc7c5941f2e8289694
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC11A2 SMARCA2 PAPPA ALAS1	8.60e-05	192	54	4	fd08ae787e936cfdb1ab8f19b0fd63005b462709
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC11A2 SMARCA2 PAPPA ALAS1	8.60e-05	192	54	4	bae236c9f1fac77bce28d0a9cf090100d391ff77
ToppCell	TCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6\|TCGA-Prostate / Sample_Type by Project: Shred V9	RALGAPA1 HUWE1 SMCR8 MED13	8.78e-05	193	54	4	abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PCLO PAX6 HUWE1 PCM1	9.13e-05	195	54	4	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	PCW_05-06-Mesenchymal\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	SGCD MEIS1 NOTCH2 FOXF2	9.32e-05	196	54	4	dca52c57ba35d9395cdbca8b881f12ece721b10f
ToppCell	CV-Moderate-6\|CV / Virus stimulation, Condition and Cluster	RASGRP1 GTF3C1 SMARCA2 HUWE1	9.32e-05	196	54	4	7bced0cc2112697593c478fa291b8ed3941fb811
ToppCell	droplet-Tongue-TONGUE-1m-Epithelial-basal_cell_of_epidermis\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMARCA2 PAPPA MEIS1 MEIS2	9.32e-05	196	54	4	d4df86ce289835e76763213641989fde77935a16
ToppCell	Influenza_Severe-NK\|Influenza_Severe / Disease group and Cell class	RASGRP1 GTF3C1 TLE5 RGS9	9.50e-05	197	54	4	d0f58ee4c02573d214deb210bb7efd3d6118f267
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-myocytic_fibroblast-Myofibroblasts-Myofibroblasts_L.2.3.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PAPPA2 SGCD PAPPA FOXF2	9.50e-05	197	54	4	16758f181ef07c60aee63072e1da9572c5c85414
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_only / Treatment groups by lineage, cell group, cell type	NOP14 SLC11A2 ALAS1 MMP15	9.50e-05	197	54	4	1a1bee8da6e04b65935c40373eaee4d6c046d9a1
ToppCell	Healthy-CD8+_Tem\|Healthy / disease group, cell group and cell class	RASGRP1 TLE5 SGCD RGS9	9.50e-05	197	54	4	8d60fdd5ce80c3496637fd3257d25258df6d7f75
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SGCD SMARCA2 MEIS1 FOXF2	9.50e-05	197	54	4	ad6c200a193a15360d17463e18a465ce1b90b8da
ToppCell	Healthy_donor-NK\|World / disease group, cell group and cell class (v2)	GTF3C1 TLE5 SGCD RGS9	9.69e-05	198	54	4	4c9c40e91173836ad0df2eba635a4cb3385e80c6
ToppCell	Non-neuronal-Dividing-Radial_Glia-vRG-20\|World / Primary Cells by Cluster	PTPRZ1 PAX6 MEIS2 NOTCH2	9.69e-05	198	54	4	bce0bc1e3f2257e0f42a1fa6e5b57cf71e4514ba
ToppCell	severe_influenza-NK\|severe_influenza / disease group, cell group and cell class (v2)	RASGRP1 GTF3C1 TLE5 RGS9	9.69e-05	198	54	4	d431beb870ff5e165d98febfb27049d729e37dc8
ToppCell	distal-2-mesenchymal-Myofibroblast\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PAPPA2 SERPINA3 SGCD PAPPA	9.88e-05	199	54	4	b8f3cf5bcfde1066bdb49b14fdc842fe9692a6b7
ToppCell	Influenza-Influenza_Severe-Lymphocyte-T/NK-NK\|Influenza_Severe / Disease, condition lineage and cell class	RASGRP1 GTF3C1 TLE5 RGS9	1.01e-04	200	54	4	04ac14414d550b14dc46d682e7af9dd43982211a
ToppCell	mild-CD8+_Tem\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RASGRP1 TLE5 XRN1 RGS9	1.01e-04	200	54	4	d8aec4904c9420b8f9d7508658ba1e36c66cdfcc
ToppCell	control\|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	PTPRZ1 PCLO MEIS1 MEIS2	1.01e-04	200	54	4	97f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	SULT1C2 KAT6A XRN1 MEIS2	1.01e-04	200	54	4	89821a264e872ed53e08e9d3609d5cc5c314503e
ToppCell	NS-control\|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PTPRZ1 PCLO MEIS1 MEIS2	1.01e-04	200	54	4	ecbe89ff95d046155b984c8c150e0b9e7278f839
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SGCD PAPPA MEIS1 FOXF2	1.01e-04	200	54	4	fb53be20392a8309a7393774c774a1b1aec6e676
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-1m-Mesenchymal-Mesoderm\|1m / Sample Type, Dataset, Time_group, and Cell type.	PAPPA2 NOP14 SLC31A1 SGCD	1.01e-04	200	54	4	c0ad32e9dd7f481c2665587fd8bd9fffc2e725f9
ToppCell	mild-gd_T\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RASGRP1 TLE5 XRN1 RGS9	1.01e-04	200	54	4	109f673a4967ffa52270a0b4f818b3461288db44
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Krt73\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PAX6 MMP15 ONECUT1	5.37e-04	131	54	3	9ca209a8652aae603c4a867ea06b06ac51e7d189
ToppCell	RA-15._Ventricular_Cardiomyocyte_III\|RA / Chamber and Cluster_Paper	SGCD ADGRD2 SMCR8	5.73e-04	134	54	3	60ee3accc54108e5b9a0018f6aa8488dc39d5ade
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma-3\|TCGA-Brain / Sample_Type by Project: Shred V9	RC3H2 KAT6A NOTCH2	5.86e-04	135	54	3	b128596653a5e3b64ed7f657bbfeda35438e2e48
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26-OPC_related-Oligodendrocyte/OPC\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	TFAP2D MED12L PAX6	6.12e-04	137	54	3	8ce463d1d74ac0ce80b812217d6bd76a788f14d2
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26-OPC_related\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	TFAP2D MED12L PAX6	6.12e-04	137	54	3	264d5e06c37d1a9ef7748091b67d2a5aa803096e
ToppCell	TCGA-Bile_Duct\|World / Sample_Type by Project: Shred V9	SERPINA3 NR5A2 ONECUT1	6.51e-04	140	54	3	ca8a0ccbc2f501b759864fe9bb06dc8b44b6b31f
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	GTF3C1 CIC	6.85e-04	32	54	2	ba89b22a5ce8ee9f3099b1fa84721724b94c7759
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	GTF3C1 CIC	6.85e-04	32	54	2	58b212d4f2955f06a195df0f79ad95a8ff145b83
ToppCell	LPS-antiTNF-Hematopoietic_Mast-Mast_cells-T-cells\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RASGRP1 MED12L ONECUT1	7.50e-04	147	54	3	1ecd7c084e73eb6fae1ab1f9aae17115d3d62cbd
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NAT8L RASGRP1 SLC11A2	7.80e-04	149	54	3	7e295b2b82dea0754e98f8cef788e2781e5d641f
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NAT8L RASGRP1 SLC11A2	7.80e-04	149	54	3	b4f77dc5f9d08b249fe5cd9a0acf86308c528ef4
ToppCell	Children_(3_yrs)-Immune-mast_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CDK15 PAX6 MEIS2	8.11e-04	151	54	3	bbf735c6433c3fc2feedb24ed6f48c51d545fb60
ToppCell	primary_visual_cortex-Non-neuronal-astrocyte\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NAT8L PTPRZ1 PAX6	8.42e-04	153	54	3	95b28c5bd10ffb74c0993ebd565038b9818e4bd2
ToppCell	primary_visual_cortex-Non-neuronal-astrocyte-Astro\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NAT8L PTPRZ1 PAX6	8.42e-04	153	54	3	b09f8def40a1ea56722f3398f61a036667b61cd9
ToppCell	primary_visual_cortex-Non-neuronal-astrocyte-Astro-Astro_Aqp4\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	NAT8L PTPRZ1 PAX6	8.42e-04	153	54	3	3ab9d55b3db51715c1d61eca142384195ce4b54f
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell_prolif\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	RGS9 ONECUT1 MEIS2	8.74e-04	155	54	3	5d157478669b609e1f0f0a75afd0112571fc2c46
ToppCell	COVID-19-Mast_cells\|COVID-19 / group, cell type (main and fine annotations)	CDK15 MED12L MEIS2	8.91e-04	156	54	3	159504d43421ee83b9ab484816333ae549c9c2fd
ToppCell	COVID-19-Mast_cells-Mast_cells\|COVID-19 / group, cell type (main and fine annotations)	CDK15 MED12L MEIS2	8.91e-04	156	54	3	bc10b94673184ef384c6665b16a1209a8975a4f1
ToppCell	Severe-B_naive-1\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	KAT6A NOTCH2 LARGE1	9.41e-04	159	54	3	2881b054bbeb479221ee3c38bbd9b0815b123579
ToppCell	Globus_pallidus-Neuronal-Excitatory\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	RASGRP1 RGS9 MEIS2	9.58e-04	160	54	3	f843287ed57d2d5a3b3f6dfb03b6934e330e6645
ToppCell	IPF-Epithelial-Ionocyte\|IPF / Disease state, Lineage and Cell class	CT62 SULT1C2 PCLO	9.58e-04	160	54	3	d65d19f4fae60836bfd4303a1bb7de34e9d83e35
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC11A2 PAPPA ALAS1	9.58e-04	160	54	3	7064af50fc10e3ea03badf415306222b74db0f95
ToppCell	IPF-Epithelial-Ionocyte\|World / Disease state, Lineage and Cell class	CT62 SULT1C2 PCLO	9.76e-04	161	54	3	f1cd5c938cdc08ad8995371b72493850a6cf277a
ToppCell	Adult-Immune-mast_cell\|Adult / Lineage, Cell type, age group and donor	CDK15 MEIS2 FOXF2	9.76e-04	161	54	3	44f5c0256b3ce264a6c7b62740f32dcd45ee052d
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	RASGRP1 RGS9 MEIS2	9.76e-04	161	54	3	ebcd5066e82b7760b9da6adc02d11258d1309dab
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADGRD2 MEIS1 MEIS2	9.76e-04	161	54	3	1b805f77790aeb8a71b08bfac2fe2eed7343258f
ToppCell	URO-Lymphocyte-T_NK-CD4_CTL\|URO / Disease, Lineage and Cell Type	RASGRP1 SGCD RGS9	9.93e-04	162	54	3	1afeeb17e263cf625a4f285203cf82f973735193
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	RALGAPA1 KAT6A SMARCA2	9.93e-04	162	54	3	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RASGRP1 SGCD PAPPA	1.03e-03	164	54	3	6fb2136168f430babfeb81ca7e151ca7a8092ec4
ToppCell	facs-Pancreas-Exocrine-24m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RALGAPA1 SLC11A2 CIC	1.03e-03	164	54	3	b895674ed2df87db8fbfb30b7e31620945588491
ToppCell	PND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NR5A2 PAX6 MEIS2	1.05e-03	165	54	3	347b59aa625a8a960828b8620824d8ac48990e07
ToppCell	PND03-Endothelial-Endothelial_lymphatic\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NR5A2 PAX6 MEIS2	1.05e-03	165	54	3	1890f9c33b0c5b381d57f97042da2610a093a6de
ToppCell	nucseq-Immune-Hematopoietic-Granulocytic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CDK15 MED12L MEIS2	1.05e-03	165	54	3	37615622c736e43260c38016e7c9e565ac97a3e8
ToppCell	PND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NR5A2 PAX6 MEIS2	1.05e-03	165	54	3	507c89ece0a336b8e9c65b79889a714e17ddca27
ToppCell	PND03-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	NR5A2 PAX6 MEIS2	1.05e-03	165	54	3	39a25be081a5d59c7cf107a997d352793d5025fb
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FOXO1 PTPRZ1 PLAGL2	1.05e-03	165	54	3	dc570154baed59ed109e5369589448e075ba66a9
ToppCell	nucseq-Immune-Hematopoietic-Granulocytic-Mast/Basophil\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CDK15 MED12L MEIS2	1.05e-03	165	54	3	640bb71e74a61df2fcb01ceeabe4c493ef836b21
ToppCell	nucseq-Immune-Hematopoietic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	CDK15 MED12L MEIS2	1.05e-03	165	54	3	f3df74b5763130c71c0a482a3a23f6b22acc2892
ToppCell	moderate-Myeloid-Mast_cell\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CDK15 HLTF MEIS2	1.07e-03	166	54	3	c3835b424c63bf11a4e2c47635dc3787fc4a637a
ToppCell	3'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PCLO PAX6 MEIS2	1.07e-03	166	54	3	9fd9de82f98b9acdaa59ac98fb9664161514aec0
ToppCell	5'-Parenchyma_lung-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-Mast_cells_L.1.4.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NAT8L CDK15 HLTF	1.08e-03	167	54	3	0aa1973141a2437df24c9857cd50ff3dfc7673c0
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-medium_spiny_neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRP1 RGS9 MEIS2	1.10e-03	168	54	3	b96a48552f4236a95bbcdce2f1b05041086d7101
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-stromal_related\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PAPPA2 OR52I1 MEIS2	1.10e-03	168	54	3	e40a3f85be7e9bb23bfbc1f9cb5e5fc54bb43863
ToppCell	COVID-19-Heart-Neuronal\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FOXO1 PTPRZ1 PAPPA	1.10e-03	168	54	3	88c2c574f428c2502b5fe099bd73b0758f668ef6
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-SPN_Neuron_STR\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRP1 RGS9 MEIS2	1.10e-03	168	54	3	b87fc63f9e35dfcfc46cb129ea569e73c5e018bb
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SGCD MEIS1 MEIS2	1.10e-03	168	54	3	d19a115365c5415e51c039718d7669de788fcf33
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PTPRZ1 PCLO NR5A2	1.10e-03	168	54	3	435ef2e4d702e978d54f9d1f5a047f39c691cc63
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-T_lymphocytic-effector_CD4-positive,_alpha-beta_T_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	RASGRP1 SMARCA2 RGS9	1.10e-03	168	54	3	07be11b6f0f37106e219692db5795c6dd32807c9
ToppCell	ASK428-Immune-Mast_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	CDK15 NR5A2 MEIS2	1.10e-03	168	54	3	c399fcb4d1d0be48026c2ecabc34a5935e7adf73
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-stromal_related-ICC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PAPPA2 OR52I1 MEIS2	1.10e-03	168	54	3	b1d6c35a5ae69c8638afd68c2be5bc9ce6fd2659
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RASGRP1 RGS9 MEIS2	1.10e-03	168	54	3	7abaddbcc55e44653d54aa15464266aa6bd5c9d2
ToppCell	Mild/Remission-B_naive-4\|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)	FOXO1 TLE5 KAT6A	1.12e-03	169	54	3	c3a6179a64589a370108fea809b157839347759c
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FOXO1 CDK15 MEIS2	1.12e-03	169	54	3	58136b8a0bf2dab45c91a053ef7225ea49ccb871
Drug	Metampicillin sodium salt [6489-61-8]; Up 200; 10.4uM; PC3; HT_HG-U133A	PAPPA2 RALGAPA1 PCLO SMARCA2 NOTCH2 LARGE1	5.49e-06	192	53	6	2123_UP
Drug	Iocetamic acid [16034-77-8]; Up 200; 6.6uM; PC3; HT_HG-U133A	PAPPA2 SGCD SRF HUWE1 NOTCH2 LARGE1	6.18e-06	196	53	6	4600_UP
Drug	N-Acetyl-DL-homocysteine Thiolactone [1195-16-0]; Up 200; 25.2uM; HL60; HT_HG-U133A	FOXO1 SULT1C2 SRF PAPPA HUWE1 ONECUT1	6.55e-06	198	53	6	2176_UP
Disease	Intellectual Disability	RALGAPA1 SLC31A1 MED12L PAX6 CIC MED13 MEIS2 LARGE1	9.38e-07	447	51	8	C3714756
Disease	Clumsiness - motor delay	MED12L MED13	2.93e-06	2	51	2	C0520947
Disease	Motor delay	MED12L MED13	8.78e-06	3	51	2	C1854301
Disease	Delayed speech and language development	MED12L MED13	2.92e-05	5	51	2	C0454644
Disease	restless legs syndrome (implicated_via_orthology)	MEIS1 MEIS2	8.15e-05	8	51	2	DOID:0050425 (implicated_via_orthology)
Disease	banks of the superior temporal sulcus volume measurement	SGCD SMARCA2	3.92e-04	17	51	2	EFO_0010286
Disease	leukemia (implicated_via_orthology)	MEIS1 MEIS2	4.92e-04	19	51	2	DOID:1240 (implicated_via_orthology)
Disease	obesity (implicated_via_orthology)	MED12L ANKRD26 MED13 NOTCH2	5.24e-04	215	51	4	DOID:9970 (implicated_via_orthology)
Disease	maximal midexpiratory flow rate	SGCD MED12L	5.46e-04	20	51	2	EFO_0004313
Disease	Attention deficit hyperactivity disorder	CIC MED13	7.89e-04	24	51	2	C1263846
Disease	glycerol measurement	PCLO SMARCA2	9.27e-04	26	51	2	EFO_0010115
Disease	Subfertility, Female	NR5A2 PAPPA	1.08e-03	28	51	2	C0341869
Disease	Sterility, Postpartum	NR5A2 PAPPA	1.08e-03	28	51	2	C0038279
Disease	Female sterility	NR5A2 PAPPA	1.08e-03	28	51	2	C0917730
Disease	Female infertility	NR5A2 PAPPA	1.08e-03	28	51	2	C0021361
Disease	waist-hip ratio	PAPPA2 TFAP2D SGCD NR5A2 XRN1 ONECUT1 MEIS1 MEIS2	1.13e-03	1226	51	8	EFO_0004343

Protein segments in the cluster

Peptide	Gene	Start	Entry
SHYMGYPHMPSMDPH	CDX4	51	O14627
VPMMSLHHLTIPYFR	SERPINA3	241	P01011
MSPYSHPHGSVAGFM	ALX3	271	O95076
PKTTMHIMIYNVHAP	DNM1P46	81	Q6ZS02
PSHPSLAHITQFRMM	RASGRP1	36	O95267
GHFVSPMAHYVPDIM	ABHD18	71	Q0P651
GMPVAHMESPERYLH	ANKRD26	481	Q9UPS8
SLMSHGSQYGMHPDQ	TFAP2D	146	Q7Z6R9
SLPPMDVMHSSVYQT	RC3H2	716	Q9HBD1
GQHMAPSPHLTVYTG	RGS9	471	O75916
STMYGDPHAARSMQP	MEIS1	21	O00470
TYTPPHMQTHMNSQP	PAX6	371	P26367
GTHMSEPPHNNMQVY	NOTCH2	2456	Q04721
AMFSYMNPHSTHGPD	OR10AD1	256	Q8NGE0
AYMIHMPHAPSFDIT	LARGE1	701	O95461
YSPISSQMMHHPQST	MED12L	1796	Q86YW9
MDILPYLHMSHGKCP	FER1L6-AS1	1	Q8NA97
RIAPTPHHTPQMMNY	ALAS1	571	P13196
YGAHAPHPNVMPASM	MEIS2	51	O14770
GYLPQPSRHMSTMRS	MMP15	61	P51511
PAMHHSQPMPRSYFI	PCLO	3131	Q9Y6V0
HTFPHSRYMSQMSVP	PCM1	81	Q15154
EHSLAGPLHPTMTMA	ONECUT1	76	Q9UBC0
GAVIMPHNMYLHSAL	SLC11A2	261	P49281
MMHARSSGPEPSYAL	PTPRZ1	916	P23471
LNPSFYGMPGHTHTM	PAPPA	546	Q13219
MYGSLPSFHAIMGPL	NOP14	701	P78316
SHPAYRHMADRMGTP	DNM2	261	P50570
LHMMKYPPSATTLHF	HUWE1	186	Q7Z6Z7
NTIMDPHAMPYSHSP	KAT6A	1761	Q92794
NPHGNMMYTGPSHHS	KAT6A	1971	Q92794
HLYHMNMTVPCPTEG	PAPPA2	936	Q9BXP8
LPHPMQMSALGGYSS	FOXO1	566	Q12778
MHTDLAQYMSQHPGG	CDK15	181	Q96Q40
MTHQSHAYHMVKPSP	MT-CO3	1	P00414
AGPSYSMPVHAAVQM	HLTF	191	Q14527
MMHTTSYRRLSPPHL	CT62	1	P0C5K7
YMDSNSTMQPSHHHP	SLC31A1	11	O15431
MLGPAYNHTMETPAS	OR52I1	1	Q8NGK6
HHVPHMSPNPGSTYM	FOXF2	271	Q12947
SMTMPPHGSLQGYQT	NR5A2	246	O00482
SPMDQHSQGYMSPHP	SMARCA2	111	P51531
HKMYPTPPSLEQHIM	MED13	831	Q9UHV7
PHSLVHNTLPMGMSY	PLAGL2	311	Q9UPG8
HNTLPMGMSYPLESS	PLAGL2	316	Q9UPG8
TTVGGHMMYPSPHAV	SRF	401	P11831
HMMYPSPHAVMYAPT	SRF	406	P11831
LHYMQESPGTSHPML	SMCR8	911	Q8TEV9
VAVSMHPGPGMRLYH	ADGRD2	751	Q7Z7M1
MYSAHRPLMPASSAA	CIC	1	Q96RK0
MMFPQSRHSGSSHLP	TLE5	1	Q08117
HLGHYPMSGGPAMLT	RALGAPA1	1516	Q6GYQ0
MPQEQYTHHRSTMPG	SGCD	1	Q92629
YHFQRMNHMLPDPGT	SULT1C2	141	O00338
GKPFHHTLYSGTMPM	XRN1	1576	Q8IZH2
MPSFQHGPGRMYHLT	TTTY12	56	Q9BZ98
MLYHIMTRPGIPESS	GTF3C1	2006	Q12789
HMGASDHYVLPGMTL	NAT8L	266	Q8N9F0